1. The diverse roles of RIP kinases in host-pathogen interactions
- Author
-
Vik Ven Eng, Madeleine A. Wemyss, and Jaclyn S. Pearson
- Subjects
NSA, necrosulfonamide ,T4SS, type IV secretion system ,RHIM, RIP homotypic interaction motif ,ERK, extracellular signal-regulated kinases ,MDP, muramyl dipeptide ,TNF, tumour necrosis factor ,RIP kinase ,0302 clinical medicine ,UPR, unfolded protein response ,RIG-I, cytosolic retinoic acid-inducible gene I ,T3SS, type III secretion system ,TGFβ, transforming growth factor beta ,AEC, airway epithelial cell ,MCMV, murine cytomegalovirus ,NP, nucleoprotein ,ZBP1, Z-DNA binding protein ,Kgp, lysine-specific protease gingipain ,COTV, Cotia poxvirus ,COVID-19, coronavirus disease 2019 ,XIAP, X-linked inhibitor of apoptosis protein ,ALRs, AIM2-like receptors ,KD, kinase domain ,Kinase ,Th1, T helper 1 ,BMDMs, bone marrow-derived macrophages ,HFMD, hand foot and mouth disease ,BclxL, Bcl-extra large ,TRAM, translocating chain-associated membrane protein ,dsRNA, double stranded RNA ,LMP1, latent membrane protein ,Cell biology ,Intracellular signal transduction ,CARD, caspase activation and recruitment domain ,SDH, succinate dehydrogenase ,TRPM7, transient receptor potential cation channel subfamily M member 7 ,IKK, IĸB kinase ,MAVS, mitochondrial antiviral signaling proteins ,NK, natural killer ,TRIF, TIR-domain-containing adapter-inducing interferon-β ,ISGF3, IFN-stimulated gene factor 3 ,Cell signaling ,AIM2, absent in melanoma 2 ,PD, Parkinson disease ,Yop, Yersinia outer protein ,JEV, Japanese encephalitis virus ,Poly(I:C), polyinosinic:polycytidylic acid ,Article ,PKR, protein kinase R ,vIRA, viral inhibitor of RIP activation ,RIPK2 ,03 medical and health sciences ,RIPK1 ,BAV, BeAn 58058 poxvirus ,NLRs, nucleotide-binding domain–like receptors ,ORF, open reading frame ,IAV, influenza A virus ,MyD88, myeloid differentiation factor 88 ,CD, Crohn’s disease ,Humans ,SARS, severe acute respiratory syndrome ,DAMPs, danger-associated molecular patterns ,GSDMD, gasdermin D ,TLR, toll-like receptor ,UL45/UL48, human CMV envelope protein 45/48 ,RR, ribonucleotide reductase ,OMV, outer membrane vesicle ,NO, nitric oxide ,Pathogen-associated molecular pattern ,TRAILR, TNF-related apoptosis-inducing ligand receptor ,COR, C-terminal of Roc ,DR, death receptor ,GEF, guanidine exchange factor ,IĸB, inhibitor of ĸB ,WT, wild-type ,Saporins ,HMGB1, high mobility group box 1 ,IL, interleukin ,MDA5, melanoma differentiation-associated protein 5 ,030104 developmental biology ,siRNA, small interfering RNA ,TBK1, TANK-binding kinase 1 ,PFT, pore-forming toxins ,ISGs, interferon stimulated genes ,Cif, cycle inhibiting factor ,RSV, respiratory syncytial virus ,TRADD, TNFR1-associated death domain protein ,Bacterial infection ,PAMPs, pathogen associated molecular patterns ,030217 neurology & neurosurgery ,Developmental Biology ,0301 basic medicine ,NSP, non-structural protein ,Bcl-2, B-cell lymphoma 2 ,CA6, coxsackievirus A6 ,DENV, dengue virus ,E3L, vaccinia virus protein E3 long ,TAK1, TGFβ-activated kinase 1 ,iE-DAP, Ɣ-d-glutamyl-mesodiaminopimelic acid ,AP-1, activator protein 1 ,vICA, viral inhibitor of caspase-8 activation ,ZIKV, Zika virus ,HIV-1, human immunodeficiency virus type 1 ,PI3K, PI3 kinase ,ATG16L1, autophagy-related 16-like 1 ,CVB, coxsackievirus B3 ,PRRs, pattern recognition receptors ,SNPs (line 657) ssRNA, single-stranded RNA ,MAPKs, mitogen-activated protein kinases ,Pathogen ,HSV, Herpes simplex virus ,DAI, DNA-dependent activator of IRFs ,EBV, Epstein-Barr virus ,M45, murine CMV virion associated protein M45 ,PGN, bacterial peptidoglycan ,DAP, diaminopimelic acid ,UBE2N, ubiquitin-conjugating enzyme E2N ,ID, intermediate domain ,NleB, non-LEE encoded effector protein B ,c-FLIP, cellular FLICE inhibitory protein ,DRP1, dynamin-related protein 1 ,vMLKL, viral MLKL-like proteins ,IRG1, immunoresponsive gene 1 ,LRR, leucine-rich repeat ,NF-ĸB, nuclear factor-ĸB ,TNFR1, TNF receptor type 1 ,WNV, West Nile virus ,HCV, hepatitis C virus ,JNK, c-Jun N-terminal kinase ,Host-Pathogen Interactions ,LPS, lipopolysaccharide ,Roc, Ras-of-complex ,PVM, pneumonia virus of mice ,NET, neutrophil extracellular traps ,HAEC, human aortic endothelial cells ,ASC, apoptosis-associated speck-like protein ,NLRC4, NLR family CARD domain containing 4 ,SARS-3a, SARS-CoV ORF protein 3a ,Cell death ,VSV, vesicular stomatitis virus ,PnCW, pneumococcal cell wall ,RIPKs, receptor interacting protein kinases ,Mtb, Mycobacterium tuberculosis ,HBeAg, hepatitis B e antigen ,Biology ,CNS, central nervous system ,cIAPs, cellular inhibitor of apoptosis proteins ,ER, endoplasmic reticulum ,IFI44L, IFN-induced protein 44-like ,NOD, nucleotide-binding oligomerization domain ,ROS, reactive oxygen species ,DISCs, death-inducing signaling complexes ,NoV, norovirus ,3Cpro, viral non-structural protein 3C ,IFN, interferon ,VV, vaccinia virus ,PR, protease ,TRAF, TNFR associated factors ,Inflammation ,CNF1, cytotoxic necrotising factor 1 ,HCMV, human cytomegalovirus ,KO, knockout ,NLRP3, NLR family pyrin domain containing 3 ,Nec-1, necrostatin-1 ,Autophagy ,IRFs, IFN regulatory factors ,Cell Biology ,CMV, cytomegalovirus ,MLKL, mixed-lineage kinase-domain like protein ,HPV, human papilloma virus ,NAIPs, NLR family apoptosis inhibitory proteins ,HBV, hepatitis B virus ,PI3P, phosphatidylinositol 3-phosphate ,RDA, RIPK1-dependent apoptosis ,Viral infection ,MKKs, MAPK kinases ,LUBAC, linear ubiquitin chain assembly complex ,BVDV, bovine viral diarrhoea virus - Abstract
Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key mediators of intracellular signal transduction including inflammation, autophagy and programmed cell death, and are thus essential for the early control of many diverse pathogenic organisms. In this review, we discuss the role of each RIPK in host responses to bacterial and viral pathogens, with a focus on studies that have used pathogen infection models rather than artificial stimulation with purified pathogen associated molecular patterns. We also discuss the intricate mechanisms of host evasion by pathogens that specifically target RIPKs for inactivation, and finally, we will touch on the controversial issue of drug development for kinase inhibitors to treat chronic inflammatory and neurological disorders, and the implications this may have on the outcome of pathogen infections.
- Published
- 2020