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34 results on '"UNAY, Bulent"'

1. Therapeutic implications of etiology-specific diagnosis of early-onset developmental and epileptic encephalopathies (EO-DEEs): A nationwide Turkish cohort study

Author

Kanmaz, Seda, Kayilioglu, Hulya, Atas, Yavuz, Olculu, Cemile Busra, Dogan, Dilara Ece Toprak, Kart, Pinar Ozkan, Yildiz, Nihal, Gumus, Hakan, Per, Huseyin, Canpolat, Mehmet, Gulec, Ayten, Yildirim, Nalan, Turk, Emre, Celik, Neslihan, Ozturk, Selcan, Kumandas, Sefer, Kilic, Betul, Topcu, Yasemin, Ozpinar, Esra, Coskun, Aysenur, Arslan, Mutluay, Akkoyunlu, Deniz Sunnetci, Cine, Naci, Uzan, Gamze Sarikaya, Gunay, Cagatay, Akyol, Duygu, Ersoy, Ozlem, Direk, Meltem Cobanogullari, Komur, Mustafa, Kirkgoz, Hilal, Karaoğlu, Pakize, Ibis, Ipek Burcu Parlak, Cerci, Cisil, Orak, Ali, Oktay, Secil, Ayanoglu, Muge, Yildirim, Mirac, Bektas, Omer, Serdaroglu, Esra, Yilmaz, Sema Bozkaya, Cankurt, Ilknur, Hirfanoglu, Tugba, Arhan, Ebru, Gencpinar, Pinar, Dundar, Nihal Olgac, Teber, Serap, Serin, Hepsen Mine, Yilmaz, Sanem, Tosun, Ayse, Polat, Muzaffer, Yilmaz, Unsal, Unalp, Aycan, Kara, Bulent, Okuyaz, Cetin, Yis, Uluc, Hiz, Semra, Aktan, Gul, Gokben, Sarenur, Unay, Bulent, Serdaroglu, Ayse, Cansu, Ali, Aydin, Kursad, and Tekgul, Hasan

Published
2024
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2. Clinical and genetic delineation of autosomal recessive and dominant ACTL6B-related developmental brain disorders

Author

Cali, Elisa, Quirin, Tania, Rocca, Clarissa, Efthymiou, Stephanie, Riva, Antonella, Marafi, Dana, Zaki, Maha S., Suri, Mohnish, Dominguez, Roberto, Elbendary, Hasnaa M., Alavi, Shahryar, Abdel-Hamid, Mohamed S., Morsy, Heba, Mau-Them, Frederic Tran, Nizon, Mathilde, Tesner, Pavel, Ryba, Lukáš, Zafar, Faisal, Rana, Nuzhat, Saadi, Nebal W., Firoozfar, Zahra, Gencpinar, Pinar, Unay, Bulent, Ustun, Canan, Bruel, Ange-Line, Coubes, Christine, Stefanich, Jennifer, Sezer, Ozlem, Agolini, Emanuele, Novelli, Antonio, Vasco, Gessica, Lettori, Donatella, Milh, Mathieu, Villard, Laurent, Zeidler, Shimriet, Opperman, Henry, Strehlow, Vincent, Issa, Mahmoud Y., El Khassab, Hebatallah, Chand, Prem, Ibrahim, Shahnaz, Nejad-Rashidi, Ali, Miryounesi, Mohammad, Larki, Pegah, Morrison, Jennifer, Cristian, Ingrid, Thiffault, Isabelle, Bertsch, Nicole L., Noh, Grace J., Pappas, John, Moran, Ellen, Marinakis, Nikolaos M., Traeger-Synodinos, Joanne, Hosseini, Susan, Abbaszadegan, Mohammad Reza, Caumes, Roseline, Vissers, Lisenka E.L.M., Neshatdoust, Maedeh, Montazer, Mostafa Zohour, El Fahime, Elmostafa, Canavati, Christin, Kamal, Lara, Kanaan, Moien, Askander, Omar, Voinova, Victoria, Levchenko, Olga, Haider, Shahzhad, Halbach, Sara S., Maia, Elias Rayana, Mansoor, Salehi, Vivek, Jain, Tawde, Sanjukta, Challa, Viveka Santhosh R., Gowda, Vykuntaraju K., Srinivasan, Varunvenkat M., Victor, Lucas Alves, Pinero-Banos, Benito, Hague, Jennifer, Ei-Awady, Heba Ahmed, Maria de Miranda Henriques-Souza, Adelia, Cheema, Huma Arshad, Anjum, Muhammad Nadeem, Idkaidak, Sara, Alqarajeh, Firas, Atawneh, Osama, Mor-Shaked, Hagar, Harel, Tamar, Zifarelli, Giovanni, Bauer, Peter, Kok, Fernando, Kitajima, Joao Paulo, Monteiro, Fabiola, Josahkian, Juliana, Lesca, Gaetan, Chatron, Nicolas, Ville, Dorothe, Murphy, David, Neul, Jeffrey L., Mullegama, Sureni V., Begtrup, Amber, Herman, Isabella, Mitani, Tadahiro, Posey, Jennifer E., Tay, Chee Geap, Javed, Iram, Carr, Lucinda, Kanani, Farah, Beecroft, Fiona, Hane, Lee, Abdelkreem, Elsayed, Macek, Milan, Bispo, Luciana, Elmaksoud, Marwa Abd, Hashemi-Gorji, Farzad, Pehlivan, Davut, Amor, David J., Jamra, Rami Abou, Chung, Wendy K., Ghayoor, Eshan Karimiani, Campeau, Philippe, Alkuraya, Fowzan S., Pagnamenta, Alistair T., Gleeson, Joseph, Lupski, James R., Striano, Pasquale, Moreno-De-Luca, Andres, Lafontaine, Denis L.J., Houlden, Henry, and Maroofian, Reza

Published
2024
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6. A multicenter cross-sectional study to evaluate the clinical characteristics and nutritional status of children with cerebral palsy

Author

Aydin, Kursad, Akbas, Yilmaz, Unay, Bulent, Arslan, Mutluay, Cansu, Ali, Sahin, Sevim, Dilber, Cengiz, Gungor, Olcay, Aksoy, Ayse, Yuksel, Deniz, Gurkas, Esra, Okuyaz, Cetin, Cobanogulları, Meltem, Eldes, Nilufer, Komur, Mustafa, Celik, Tamer, Per, Huseyin, Acer, Hamit, Gencpinar, Pınar, Dundar, Nihal Olgac, Unalp, Aycan, Edizer, Selvinaz, Yarar, Coskun, Carman, Kursat Bora, Arslan, Elif Acar, Kartal, Ayse, Gungor, Serdal, Ozgor, Bilge, Calik, Mustafa, Turkdogan, Dilsat, Unver, Olcay, Poyrazoglu, Hatice Gamze, Isikay, Sedat, and Sarioglu, Aysugul Alptekin

Published
2018
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12. Evaluation of micronutrient levels in children with cerebral palsy

Author

Carman, Kursat Bora, primary, Aydın, Kursad, additional, Kilic Aydin, Betul, additional, Cansu, Ali, additional, Direk, Meltem Cobanogullari, additional, Durmus, Selver, additional, Dündar, Nihal Olgaç, additional, Gencpinar, Pinar, additional, Gungor, Serdal, additional, Gurkas, Esra, additional, Hur, Ozgen, additional, Karadag, Meral, additional, Karademir, Cefa Nil, additional, Ozkan Kart, Pinar, additional, Okuyaz, Cetin, additional, Oz, Nefise Arıbas, additional, Peduk, Yakup, additional, Per, Huseyin, additional, Serin, Mine Hepsen, additional, Tekgul, Hasan, additional, Unay, Bulent, additional, Yarar, Coskun, additional, and Yildirim, Gonca Kilic, additional

Published
2022
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20. Cardiac troponin-I, brain natriuretic peptide and endothelin-1 levels in a rat model of doxorubicin-induced cardiac injury

Author

Atas, Erman, Kismet, Erol, Kesik, Vural, Karaoglu, Baki, Aydemir, Gokhan, Korkmazer, Nadir, Demirkaya, Erkan, Karslioglu, YıLdirim, Yurttutan, Neval, Unay, Bulent, Koseoglu, Vedat, and Gokcay, Erdal

Subjects
Anthracyclines -- Research -- Health aspects, Doxorubicin -- Research, Natriuretic peptides -- Research -- Health aspects, Health
Abstract

Byline: Erman. Atas, Erol. Kismet, Vural. Kesik, Baki. Karaoglu, Gokhan. Aydemir, Nadir. Korkmazer, Erkan. Demirkaya, Y?ldirim. Karslioglu, Neval. Yurttutan, Bulent. Unay, Vedat. Koseoglu, Erdal. Gokcay Background: Cardiotoxicity, during or after [...]

Published
2015

22. Transverse Myelitis: An unusual association

Author

KALKAN, Gokhan, KARAOGLU, Abdulbaki, VURUCU, Sebahattin, UNAY, Bulent, GOK, Faysal, AKİN, Ridvan, and ARSLAN, Mehmet Tayyip

Abstract

Transverse myelitis (TM) is an acute inflammation of spinal cord characterized by demyelination. Infectious, inflammatory and autoimmune etiologies constitute the most common etiologies of TM. It is believed that pathlogical changes in infection related cases occur due to altered immune response rather than direct effect of the infection. Methicillin resistant Staphylococcus aureus (MRSA) a well known agent of hospital and sometimes community acquired pneumonia leads to increased morbidity and mortality. Here we describe a case of transverse myelitis as an unusual complication of MRSA pneumonia. To our knowledge, this is the first reported case of transverse myelitis developed with MRSA pneumonia. Key words: Methycilline resistant staphylococcus aureus, pneumonia, transverse myelitis

Published
2015

32. The effects of oxcarbazepine treatment on vitamin B12 and folate levels, thyroid functions, sex hormones, and bone mineral density in epileptic patients.

Author

Vurucu, Sebahattin, Gulgun, Mustafa, Yesilkaya, Ediz, Unay, Bulent, and Akin, Ridvan

Abstract

The aim of this study was to evaluate vitamin B12 and folate levels, thyroid functions, sex hormones and bone mineral density in idiopathic epileptic patients taking oxcarbazepine as monotherapy. Newly diagnosed pediatric patients with idiopathic partial epilepsy taking oxcarbazepine (OXC) as monotherapy were enrolled in this study. The pre-treatment and 6 months post-treatment values of vitamin B12, folate, thyroid functions, sex hormones, and bone mineral density (BMD) were obtained from all patients. A total of 32 patients (22 (68.8%) males and 10 (31.2%) females) were included in this study. The mean age was 7.4 ± 3.2 years (range: 2–14 years). There were no significant differences between the pre-treatment and 6 months post-treatment values of vitamin B12, folate, thyroid functions, sex hormones, and BMD. However, the 6 month post-treatment sex hormone binding globulin (SHBG) values (159.92 ± 48.14 nmol/L) were significantly higher than the pre-treatment values (137.88 ± 43.12 nmol/L) (p=0.009). We found that OCX treatment in children did not have an effect on serum folate and vitamin B12 levels, thyroid functions, sex hormones and BMD but caused increased SHBG. Over time, the increase in serum SHBG levels may lead to diminished bioactivity of sex steroids, and thus to reduced fertility. The further studies are needed to demonstrate the clinical importance of increased SHBG levels. [ABSTRACT FROM AUTHOR]

Published
2009
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33. Determination of risk factors associated with seizure relapse after antiepileptic drug withdrawal

Author

Vurucu, Sebahattin, Saldir, Mehmet, Unay, Bulent, and Akin, Ridvan

Abstract

Abstract: There is no consensus regarding the time of antiepileptic drug withdrawal and the relevant risk factors for seizure relapse. In this study, we aimed to determine the seizure relapse rates and the associated risk factors for seizure relapse in childhood epilepsy. Two-hundred sixty-six epileptic patients who discontinued the antiepileptic drug therapy after a seizure-free period of at least two years, were enrolled into the study. The data of the patients regarding sex, febrile convulsion history, family history, age at onset, type of epilepsy, total number of seizures and antiepileptic drugs, seizures during treatment, mental status, first and last electroencephalography, brain imaging findings, etiological factors and seizure relapse in the first two years after antiepileptic drug withdrawal were obtained from the patients’ files. Univariate logistic regression analysis was performed for each variable. The variables which were found to be statistically significant in univariate analysis, were included in multivariate logistic regression analysis. The overall seizure relapse rate after antiepileptic drug withdrawal was 19.2%. There were no significant differences for seizure relapse rate after antiepileptic drug withdrawal between patient groups with respect to sex, family history, type of epilepsy, febrile convulsion history, seizures before treatment, first electroencephalography findings, brain imaging findings and etiology. However, there were statistically significant differences for seizure relapse rate among patient groups concerning age at onset of epilepsy, new seizure during treatment, the total number of antiepileptic drugs, mental status, and last electroencephalography findings. We imply that the clinical status of the patients should be considered before the cessation of drug therapy rather than the etiological factors or laboratory findings.

Published
2010
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34. Serum and liver tissue biotinidase enzyme activity in rats which were administrated to valproic acid

Author

Korkmazer, Nadir, Vurucu, Sebahattin, Demirkaya, Erkan, Unay, Bulent, Kul, Mustafa, Akin, Rıdvan, and Gokcay, Erdal

Subjects
*ACETIC acid, *VALPROIC acid, *BLOOD plasma, *ABDOMEN
Abstract

Abstract: Valproic acid (VPA) is an antiepileptic drug widely used and well-tolerated by most of patients. Its non-dose-dependent side effects seen mostly are the temporary gastrointestinal disturbances including anorexia and nausea, and hepatoxicity. As to its dose-dependent side effects are the weight loss, tremor, skin eruption and the alopecia. In this study we aimed to put forward the biotinidase deficiency considered as a possible cause of alopecia in the rats administered with valproic acid, and the correlation between liver and serum biotinidase enzyme activities (BEA) and transaminases, albumin and serum valproic acid levels. In our study, 4 groups of which one of them was a control group, each consisting of 15 male Wistar rats was organized. 200, 400, and 600mg/kg/day of VPA, and distilled water, two divided doses per day, were administered per orally to VPA-1, VPA-2, VPA-3, and control group, respectively, in 60 days. Their serum and liver biotinidase enzyme activities, serum AST, ALT, albumin, and valproic acid levels were measured. Alopecia was seen in the subjects of 6.6% of VPA-1, 13.3% of VPA-2, and 26.6% of VPA-3. Significant difference in the liver tissues BEA was noted only between VPA-3 and the control group. Reductions were observed both in the liver tissues BEA and the serum BEA levels, which are inversely proportional to the VPA doses. A positive correlation between the liver biotinidase enzyme activities and the serum valproic acid levels, and the negative correlation between the liver tissues biotinidase activities and the serum valproic acid levels were noted, respectively. As a conclusion, the partial alopecia which is an initial symptom of reduced biotinidase activity may also be created depending on the reduction of biotinidase activity during valproic acid therapy. The alopecia which may further be observed in the patients receiving valproic acid therapy may be prevented by means of administration of biotin in a dose of 10mg/day. [Copyright &y& Elsevier]

Published
2006
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