1,218 results on '"Uckun, Fatih M."'
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2. Role of Clinical Pharmacodynamics Studies in the Era of Precision Medicines Against Cancer
3. Non-clinical safety profile and pharmacodynamics of two formulations of the anti-sepsis drug candidate Rejuveinix (RJX)
4. Editorial: Coronavirus disease (COVID-19): mechanistic basic, translational, and clinical research aimed at identification of effective preventive and therapeutic strategies
5. Upregulated Expression of ErbB1 in Diffuse Large B-Cell Lymphoma as a Predictor of Poor Overall Survival Outcome
6. Role of PRKCM (PKCμ) in Radiation-Induced Increase of JUN Protooncogene mRNA Levels in B-Lineage Lymphoid Cells
7. In Vivo Antioxidant Activity of Genistein in a Murine Model of Singlet Oxygen-Induced Cerebral Stroke
8. Increased Hydroxyl Radical Production and Apoptosis in PC12 Neuron Cells Expressing the Gain-of-Function Mutant G93A SOD1 Gene
9. Expression of Dominant-Negative and Mutant Isoforms of the Antileukemic Transcription Factor Ikaros in Infant Acute Lymphoblastic Leukemia
10. High Intra-Tumor Transforming Growth Factor Beta 2 Level as a Predictor of Poor Treatment Outcomes in Pediatric Diffuse Intrinsic Pontine Glioma
11. CD22 Exon 12 Deletion as an Independent Predictor of Poor Treatment Outcomes in B-ALL
12. Role of Clinical Pharmacokinetics Studies in Contemporary Oncology Drug Development
13. Role of Clinical Pharmacodynamics Studies in the Era of Precision Medicines Against Cancer
14. Redox-responsive, reversibly-crosslinked thiolated cationic helical polypeptides for efficient siRNA encapsulation and delivery
15. ERBB1/EGFR and JAK3 Tyrosine Kinases as Potential Therapeutic Targets in High-Risk Multiple Myeloma
16. Evaluation of the potential of Rejuveinix plus dexamethasone against sepsis
17. SARS-CoV-2 Vaccine Efficacy in Patients with Hematologic Malignancies: Practical Points for Further Research
18. Augmented Expression of the IL3RA/CD123 Gene in MLL/KMT2A-Rearranged Pediatric AML and Infant ALL
19. Upregulated Expression of ERBB2/HER2 in Multiple Myeloma as a Predictor of Poor Survival Outcomes.
20. RJX Improves Wound Healing in Diabetic Rats
21. Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia
22. SCID Mouse Models of Human Leukemia and Lymphoma as Tools for New Agent Development
23. Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros
24. Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia
25. Impact of Therapy in Patients with Hematologic Malignancies on Seroconversion Rates After SARS-CoV-2 Vaccination
26. Clinical and Non-clinical Proof of Concept Supporting the Development of RJX As an Adjunct to Standard of Care Against Severe COVID-19
27. Post-hoc Analysis of Pharmacodynamics and Single-Agent Activity of CD3xCD123 Bispecific Antibody APVO436 in Relapsed/Refractory AML and MDS Resistant to HMA or Venetoclax Plus HMA
28. Cancer drug resistance in multiple myeloma
29. Tyrosine kinases in KMT2A/MLL-rearranged acute leukemias as potential therapeutic targets to overcome cancer drug resistance
30. CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia
31. STAT3 Is a Substrate of Syk Tyrosine Kinase in B-lineage Leukemia/lymphoma Cells Exposed to Oxidative Stress
32. Dual Targeting of Multiple Myeloma Stem Cells and Myeloid-Derived Suppressor Cells for Treatment of Chemotherapy-Resistant Multiple Myeloma
33. Antibody Responses to COVID-19 Vaccination in Cancer: A Systematic Review
34. Risk, Characteristics and Biomarkers of Cytokine Release Syndrome in Patients with Relapsed/Refractory AML or MDS Treated with CD3xCD123 Bispecific Antibody APVO436
35. Leveraging Structure-Based Rational Drug Design and Nanotechnology to Destroy Leukemic Stem Cells
36. CD123-Directed Bispecific Antibodies for Targeting MDS Clones and Immunosuppressive Myeloid-Derived Suppressor Cells (MDSC) in High-Risk Adult MDS Patients
37. A Clinical Phase 1B Study of the CD3xCD123 Bispecific Antibody APVO436 in Patients with Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
38. CD22ΔE12 as a molecular target for RNAi therapy
39. Isolation and Characterization of Pokeweed Antiviral Protein Mutations in Saccharomyces cerevisiae: Identification of Residues Important for Toxicity
40. Membrane-Associated CD19-LYN Complex is an Endogenous p53-Independent and Bcl-2-Independent Regulator of Apoptosis in Human B-Lineage Lymphoma Cells
41. Immunobiologic Differences between Normal and Leukemic Human B-Cell Precursors
42. Interleukin 7 Receptor Engagement Stimulates Tyrosine Phosphorylation, Inositol Phospholipid Turnover, Proliferation, and Selective Differentiation to the CD4 Lineage by Human Fetal Thymocytes
43. Antigen-Independent Regulation of Cytoplasmic Calcium in B Cells with a 12-kDa B-Cell Growth Factor and Anti-CD19
44. Tyrosine Phosphorylation is a Mandatory Proximal Step in Radiation-Induced Activation of the Protein Kinase C Signaling Pathway in Human B-Lymphocyte Precursors
45. Engagement of the CD19 Receptor on Human B-Lineage Leukemia Cells Activates LCK Tyrosine Kinase and Facilitates Radiation-Induced Apoptosis
46. Antibody responses to COVID-19 vaccination in cancer: a systematic review
47. Rejuveinix Mitigates Sepsis-Associated Oxidative Stress in the Brain: Clinical Impact Potential in COVID-19 and Nervous System Disorders
48. Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma
49. Targeting Solid Tumors With BTK Inhibitors
50. Anti-inflammatory activity profile of JANEX-1 in preclinical animal models
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