179 results on '"Udelson J"'
Search Results
2. Agreement between four high-sensitivity cardiac troponin assays and non-invasive testing, clinical and quality of care outcomes based on the 2020 ESC guidelines: results from the ROMICAT II trial
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Karady, J, primary, Mayrhofer, T, additional, Nagurney, J T, additional, Udelson, J E, additional, Fleg, J L, additional, Peacock, W F, additional, Januzzi, J L, additional, Koenig, W, additional, Ferencik, M, additional, and Hoffmann, U, additional more...
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- 2022
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Catalog
3. Maximally tolerated guideline-directed medical therapy and barriers to optimization in patients with heart failure with reduced ejection fraction: the COAPT trial
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Cox, Z, primary, Zalawadiya, S, additional, Simonato, M, additional, Redfors, B, additional, Zhou, Z, additional, Kotinkaduwa, L, additional, Zile, M, additional, Udelson, J, additional, Lim, D S, additional, Grayburn, P A, additional, Mack, M J, additional, Abraham, W T, additional, Stone, G W, additional, and Lindenfeld, J, additional more...
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- 2022
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4. No-implant Interatrial Shunt for Heart Failure With Preserved Ejection Fraction: Six-Month Outcomes from Multi-Centre Pilot Feasibility Studies
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Gooley, R., Udelson, J., Barker, C., Wilkins, G., Wilkins, B., Lockwood, S., Potter, B., Meduri, C., Fail, P., Solet, D., Feldt, K., Kriegel, J., and Shaburishvili, T.
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- 2024
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5. Cost-effectiveness Analysis Of Non-invasive Testing Strategies For Stable Chest Pain Evaluation - Comparison Of Functional Testing, Coronary CTA, And Non-invasive FFRCTBased On The PROMISE Trial
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Mayrhofer, T., primary, Karady, J., additional, Ivanov, A., additional, Foldyna, B., additional, Lu, M., additional, Ferencik, M., additional, Pursnani, A., additional, Salerno, M., additional, Udelson, J., additional, Mark, D., additional, Douglas, P., additional, and Hoffmann, U., additional more...
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- 2020
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6. Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial
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Butler, J, Khan, M, Anker, S, Fonarow, G, Kim, R, Nodari, S, O'Connor, C, Pieske, B, Pieske-Kraigher, E, Sabbah, H, Senni, M, Voors, A, Udelson, J, Carr, J, Gheorghiade, M, Filippatos, G, Butler J, Khan MS, Anker SD, Fonarow GC, Kim RJ, Nodari S, O'Connor CM, Pieske B, Pieske-Kraigher E, Sabbah HN, Senni M, Voors AA, Udelson JE, Carr J, Gheorghiade M, Filippatos G, Butler, J, Khan, M, Anker, S, Fonarow, G, Kim, R, Nodari, S, O'Connor, C, Pieske, B, Pieske-Kraigher, E, Sabbah, H, Senni, M, Voors, A, Udelson, J, Carr, J, Gheorghiade, M, Filippatos, G, Butler J, Khan MS, Anker SD, Fonarow GC, Kim RJ, Nodari S, O'Connor CM, Pieske B, Pieske-Kraigher E, Sabbah HN, Senni M, Voors AA, Udelson JE, Carr J, Gheorghiade M, and Filippatos G more...
- Abstract
Background: Elamipretide, a novel mitochondrial modulating agent, improves myocardial energetics; however, it is unknown whether this mechanistic benefit translates into improved cardiac structure and function in heart failure (HF) with reduced ejection fraction (HFrEF). The objective of this study was to evaluate the effects of multiple subcutaneous doses of elamipretide on left ventricular end systolic volume (LVESV) as assessed by cardiac magnetic resonance imaging. Methods: We randomized 71 patients with HFrEF (LVEF ≤ 40%) in a double-blind, placebo-controlled trial in a 1:1:1 ratio to receive placebo, 4 mg or 40 mg elamipretide once daily for 28 consecutive days. Results: The mean age (standard deviation) of the study population was 65 ± 10 years, 24% were females, and the mean EF was 31% ± 7%. The change in LVESV from baseline to week 4 was not significantly different between elamipretide 4 mg (89.4 mL to 85 mL; difference, −4.4 mL) or 40 mg (77.9 mL to 76.6 mL; difference, −1.2 mL) compared with placebo (77.7 mL to 74.6 mL; difference, −3.8 mL) (4 mg vs placebo: difference of means, −0.3; 95% CI, −4.6 to 4.0; P = 0.90; and 40 mg vs placebo: difference of means, 2.3; 95% CI, −1.9 to 6.5; P = 0.28). Also, no significant differences in change in LVESV and LVEF were observed between placebo and either of the elamipretide groups. Rates of any study drug-related adverse events were similar in the 3 groups. Conclusions: Elamipretide was well tolerated but did not improve LVESV at 4 weeks in patients with stable HFrEF compared with placebo. more...
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- 2020
7. Radionuclide imaging in risk assessment after acute coronary syndromes
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Udelson, J E and Flint, E J
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- 2004
8. Estimating the real-world performance of the PROMISE minimal-risk tool.
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Nanna, MG, Wang, TY, Chiswell, K, Sun, JL, Vemulapalli, S, Hoffmann, U, Patel, MR, Udelson, JE, Fordyce, CB, Douglas, PS, Nanna, M G, Wang, T Y, Sun, L, Patel, M R, Udelson, J E, Fordyce, C B, Douglas, P S, and Sun, J L more...
- Abstract
Background: Stable chest pain is a common indication for cardiac catheterization. We assessed the prognostic value of the Prospective Multicenter Imaging Study for Evaluation (PROMISE) Minimal-Risk Tool in identifying patients who are at very low risk of obstructive coronary artery disease (CAD) or downstream cardiovascular adverse outcomes.Methods: We applied the PROMISE Minimal-Risk Tool to consecutive patients without known CAD who underwent elective cardiac catheterization for stable angina from January 1, 2000 to December 31, 2014 in the Duke Databank for Cardiovascular Disease (DDCD). Patients with scores >0.46 (top decile of lowest-risk from the PROMISE cohort) were classified as low-risk. Logistic regression modeling compared likelihood of freedom from obstructive coronary artery disease on index angiography, 2-year survival, and 2-year survival free of myocardial infarction (MI) and MI/revascularization between low- and non low-risk patients. Alternative cut points to define low- risk patients were also explored.Results: Among 6251 patients undergoing cardiac catheterization for stable chest pain, 1082 (17.3%) were low-risk per the PROMISE minimal-risk tool. Among low risk patients, obstructive coronary artery disease was observed in 14.9% and left main disease (≥ 50% Stenosis) was rare (0.9%). Compared with other patients, low risk patients had a higher likelihood of freedom from obstructive coronary disease on index catheterization (85.1% vs. 44.2%, OR 4.84, 95% CI 4.06-5.77). Low risk patients had significantly higher survival (98.2% vs. 94.4%, OR 3.18, 95% CI 1.99-5.08), MI-free survival (97.2% vs. 91.9%, OR 3.03, 95% CI 2.07-4.45), and MI/revascularization-free survival (86.2 vs. 59.9%, OR 4.19, 95% CI 3.48-5.05) at 2 years than non-low risk patients. Operating characteristics for predicting the outcomes of interest varied modestly depending on the low-risk cut-point used but the positive predictive value for 2 year freedom from death was >98% regardless.Conclusion: The PROMISE minimal-risk tool identifies 17% of stable chest pain patients referred to cardiac catheterization as low risk. These patients have a low prevalence of obstructive CAD and better survival than non-low risk patients. While this suggests that these patients are unlikely to benefit from catheterization, further research is needed to confirm a favorable downstream prognosis with medical management alone. [ABSTRACT FROM AUTHOR] more...- Published
- 2021
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9. Association Between Body Mass Index, Testing Performance And Clinical Outcomes In Patients With Stable Chest Pain: Insights From The PRECISE (Prospective Randomized Trial Of The Optimal Evaluation Of Cardiac Symptoms And Revascularization) Trial.
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Ferencik, M., Vemulapalli, S., Nanna, M., Kelsey, M., Mark, D., Leipsic, J., Ng, N., Maurovich-Horvat, P., Mullen, S., Rogers, C., Udelson, J., and Douglas, P.
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- 2024
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10. P3522Vagus nerve stimulation for chronic heart failure: differences in therapy delivery and clinical efficacy in ANTHEM-HF, INOVATE-HF, and NECTAR-HF
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Anand, I, primary, Konstam, M, additional, Udelson, J, additional, Butler, J, additional, Klein, H, additional, Parker, J, additional, Teerlink, J, additional, Libbus, I, additional, Amurthur, B, additional, Kenknight, B, additional, Ardell, J, additional, Gregory, D, additional, Massaro, J, additional, and Dicarlo, L, additional more...
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- 2019
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11. 3303Classification of patients with acute chest pain by analytical benchmarks and subsequent management recommendations - A comparison of three highly-sensitivity troponin assays in the ROMICAT trials
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Karady, J, primary, Mayrhofer, T, additional, Ferencik, M, additional, Udelson, J E, additional, Fleg, J L, additional, Peacock, W F, additional, Januzzi Jr, J L, additional, Nagurney, J T, additional, Koenig, W F, additional, and Hoffmann, U, additional more...
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- 2019
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12. 3209High-risk coronary plaque is an independent predictor of major adverse cardiovascular events in patients with stable chest pain: Results from PROMISE
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Ferencik, M., primary, Mayrhofer, T., additional, Bittner, D., additional, Emami, H., additional, Puchner, S., additional, Lu, M., additional, Meyersohn, N., additional, Ivanov, A., additional, Adami, E., additional, Patel, M., additional, Mark, D., additional, Udelson, J., additional, Lee, K., additional, Douglas, P., additional, and Hoffmann, U., additional more...
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- 2017
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13. Exploring New Endpoints for Patients With Heart Failure With Preserved Ejection Fraction
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Butler, J, Hamo, C, Udelson, J, Pitt, B, Yancy, C, Shah, S, Desvigne-Nickens, P, Bernstein, H, Clark, R, Depre, C, Dinh, W, Hamer, A, Kay-Mugford, P, Kramer, F, Lefkowitz, M, Lewis, K, Maya, J, Maybaum, S, Patel, M, Pollack, P, Roessig, L, Rotman, S, Salsali, A, Sims, J, Senni, M, Rosano, G, Dunnmon, P, Stockbridge, N, Anker, S, Zile, M, Gheorghiade, M, Butler J, Hamo CE, Udelson JE, Pitt B, Yancy C, Shah SJ, Desvigne-Nickens P, Bernstein HS, Clark RL, Depre C, Dinh W, Hamer A, Kay-Mugford P, Kramer F, Lefkowitz M, Lewis K, Maya J, Maybaum S, Patel MJ, Pollack PS, Roessig L, Rotman S, Salsali A, Sims JJ, Senni M, Rosano G, Dunnmon P, Stockbridge N, Anker SD, Zile MR, Gheorghiade M, Butler, J, Hamo, C, Udelson, J, Pitt, B, Yancy, C, Shah, S, Desvigne-Nickens, P, Bernstein, H, Clark, R, Depre, C, Dinh, W, Hamer, A, Kay-Mugford, P, Kramer, F, Lefkowitz, M, Lewis, K, Maya, J, Maybaum, S, Patel, M, Pollack, P, Roessig, L, Rotman, S, Salsali, A, Sims, J, Senni, M, Rosano, G, Dunnmon, P, Stockbridge, N, Anker, S, Zile, M, Gheorghiade, M, Butler J, Hamo CE, Udelson JE, Pitt B, Yancy C, Shah SJ, Desvigne-Nickens P, Bernstein HS, Clark RL, Depre C, Dinh W, Hamer A, Kay-Mugford P, Kramer F, Lefkowitz M, Lewis K, Maya J, Maybaum S, Patel MJ, Pollack PS, Roessig L, Rotman S, Salsali A, Sims JJ, Senni M, Rosano G, Dunnmon P, Stockbridge N, Anker SD, Zile MR, and Gheorghiade M more...
- Abstract
The epidemiological, clinical, and societal implications of the heart failure (HF) epidemic cannot be overemphasized. Approximately half of all HF patients have HF with preserved ejection fraction (HFpEF). HFpEF is largely a syndrome of the elderly, and with aging of the population, the proportion of patients with HFpEF is expected to grow. Currently, there is no drug known to improve mortality or hospitalization risk for these patients. Besides mortality and hospitalization, it is imperative to realize that patients with HFpEF have significant impairment in their functional capacity and their quality of life on a daily basis, underscoring the need for these parameters to ideally be incorporated within a regulatory pathway for drug approval. Although attempts should continue to explore therapies to reduce the risk of mortality or hospitalization for these patients, efforts should also be directed to improve other patient-centric concerns, such as functional capacity and quality of life. To initiate a dialogue about the compelling need for and the challenges in developing such alternative endpoints for patients with HFpEF, the US Food and Drug Administration on November 12, 2015, facilitated a meeting represented by clinicians, academia, industry, and regulatory agencies. This document summarizes the discussion from this meeting. more...
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- 2016
14. A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: Analysis from the EVEREST trial
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Gheorghiade, M. Pang, P.S. Ambrosy, A.P. Lan, G. Schmidt, P. Filippatos, G. Konstam, M. Swedberg, K. Cook, T. Traver, B. Maggioni, A. Burnett, J. Grinfeld, L. Udelson, J. Zannad, F.
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Hospitalization for worsening chronic heart failure results in high post-discharge mortality, morbidity, and cost. However, thorough characterization, soon after discharge of patients with early post-discharge events has not been previously performed. The objectives of this study were to describe the baseline, in-hospital, and post-discharge clinical, laboratory, and neurohormonal profiles of patients hospitalized for worsening heart failure with reduced ejection fraction (EF) who die or are re-admitted for cardiovascular (CV) causes within 90 days of initial hospitalization. Retrospective analysis of 4,133 patients hospitalized for worsening heart failure with EF B40% in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial, which randomized patients to tolvaptan or placebo, both in addition to standard therapy. Clinical and laboratory parameters were obtained within 48 h of admission, during hospitalization, and post-discharge weeks 1, 4, 8, and every 8 weeks thereafter for a median of 9.9 months. Patients with events within 90 days were compared with those with later/no events. All-cause mortality (ACM) and CV re-hospitalization were independently adjudicated. Within 90 days of admission, 395 patients (9.6%) died and 801 patients (19.4%) were re-hospitalized for CV causes. Significant baseline and longitudinal differences were seen between groups with early versus later ([90 days) or no events at 12 months post-randomization. Post-discharge outcomes were similar in the tolvaptan and placebo groups. Patients with early post-discharge events experienced clinically significant worsening in signs and symptoms, laboratory values, and neurohormonal parameters soon after discharge. Identifying these abnormalities may facilitate efforts to reduce post-discharge mortality and re-hospitalization. © 2011 Springer Science+Business Media, LLC. more...
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- 2012
15. Abstracts
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Dunet, V., primary, Dabiri, A., additional, Allenbach, G., additional, Goyeneche Achigar, A., additional, Waeber, B., additional, Feihl, F., additional, Heinzer, R., additional, Prior, J. O., additional, Van Velzen, J. E., additional, Schuijf, J. D., additional, De Graaf, F. R., additional, De Graaf, M. A., additional, Schalij, M. J., additional, Kroft, L. J., additional, De Roos, A., additional, Jukema, J. W., additional, Van Der Wall, E. E., additional, Bax, J. J., additional, Lankinen, E., additional, Saraste, A., additional, Noponen, T., additional, Klen, R., additional, Teras, M., additional, Kokki, T., additional, Kajander, S., additional, Pietila, M., additional, Ukkonen, H., additional, Knuuti, J., additional, Pazhenkottil, A. P., additional, Nkoulou, R. N., additional, Ghadri, J. R., additional, Herzog, B. A., additional, Buechel, R. R., additional, Kuest, S. M., additional, Wolfrum, M., additional, Gaemperli, O., additional, Husmann, L., additional, Kaufmann, P. A., additional, Andreini, D., additional, Pontone, G., additional, Mushtaq, S., additional, Antonioli, L., additional, Bertella, E., additional, Formenti, A., additional, Cortinovis, S., additional, Ballerini, G., additional, Fiorentini, C., additional, Pepi, M., additional, Koh, A. S., additional, Flores, J. S., additional, Keng, F. Y. J., additional, Tan, R. S., additional, Chua, T. S. J., additional, Annoni, A. D., additional, Tamborini, G., additional, Fusari, M., additional, Bartorelli, A. L., additional, Ewe, S. H., additional, Ng, A. C. T., additional, Delgado, V., additional, Schuijf, J., additional, Van Der Kley, F., additional, Colli, A., additional, De Weger, A., additional, Marsan, N. A., additional, Yiu, K. H., additional, Ng, A. C., additional, Timmer, S. A. J., additional, Knaapen, P., additional, Germans, T., additional, Dijkmans, P. A., additional, Lubberink, M., additional, Ten Berg, J. M., additional, Ten Cate, F. J., additional, Russel, I. K., additional, Lammertsma, A. A., additional, Van Rossum, A. C., additional, Wong, Y. Y., additional, Ruiter, G., additional, Raijmakers, P., additional, Van Der Laarse, W. J., additional, Westerhof, N., additional, Vonk-Noordegraaf, A., additional, Youssef, G., additional, Leung, E., additional, Wisenberg, G., additional, Marriot, C., additional, Williams, K., additional, Etele, J., additional, Dekemp, R. A., additional, Dasilva, J., additional, Birnie, D., additional, Beanlands, R. S. B., additional, Thompson, R. C., additional, Allam, A. H., additional, Wann, L. S., additional, Nureldin, A. H., additional, Adelmaksoub, G., additional, Badr, I., additional, Sutherland, M. L., additional, Sutherland, J. D., additional, Miyamoto, M. I., additional, Thomas, G. S., additional, Harms, H. J., additional, De Haan, S., additional, Huisman, M. C., additional, Schuit, R. C., additional, Windhorst, A. D., additional, Allaart, C., additional, Einstein, A. J., additional, Khawaja, T., additional, Greer, C., additional, Chokshi, A., additional, Jones, M., additional, Schaefle, K., additional, Bhatia, K., additional, Shimbo, D., additional, Schulze, P. C., additional, Srivastava, A., additional, Chettiar, R., additional, Moody, J., additional, Weyman, C., additional, Natale, D., additional, Bruni, W., additional, Liu, Y., additional, Ficaro, E., additional, Sinusas, A. J., additional, Peix, A., additional, Batista, E., additional, Cabrera, L. O., additional, Padron, K., additional, Rodriguez, L., additional, Sainz, B., additional, Mendoza, V., additional, Carrillo, R., additional, Fernandez, Y., additional, Mena, E., additional, Naum, A., additional, Bach-Gansmo, T., additional, Kleven-Madsen, N., additional, Biermann, M., additional, Johnsen, B., additional, Aase Husby, J., additional, Rotevatn, S., additional, Nordrehaug, J. E., additional, Schaap, J., additional, Kauling, R. M., additional, Post, M. C., additional, Rensing, B. J. W. M., additional, Verzijlbergen, J. F., additional, Sanchez, J., additional, Giamouzis, G., additional, Tziolas, N., additional, Georgoulias, P., additional, Karayannis, G., additional, Chamaidi, A., additional, Zavos, N., additional, Koutrakis, K., additional, Sitafidis, G., additional, Skoularigis, J., additional, Triposkiadis, F., additional, Radovanovic, S., additional, Djokovic, A., additional, Simic, D. V., additional, Krotin, M., additional, Savic-Radojevic, A., additional, Pljesa-Ercegovac, M., additional, Zdravkovic, M., additional, Saponjski, J., additional, Jelic, S., additional, Simic, T., additional, Eckardt, R., additional, Kjeldsen, B. J., additional, Andersen, L. I., additional, Haghfelt, T., additional, Grupe, P., additional, Johansen, A., additional, Hesse, B., additional, Pena, H., additional, Cantinho, G., additional, Wilk, M., additional, Srour, Y., additional, Godinho, F., additional, Zafrir, N., additional, Gutstein, A., additional, Mats, I., additional, Battler, A., additional, Solodky, A., additional, Sari, E., additional, Singh, N., additional, Vara, A., additional, Peters, A. M., additional, De Belder, A., additional, Nair, S., additional, Ryan, N., additional, James, R., additional, Dizdarevic, S., additional, Depuey, G., additional, Friedman, M., additional, Wray, R., additional, Old, R., additional, Babla, H., additional, Chuanyong, B., additional, Maddahi, J., additional, Tragardh Johansson, E., additional, Sjostrand, K., additional, Edenbrandt, L., additional, Aguade-Bruix, S., additional, Cuberas-Borros, G., additional, Pizzi, M. N., additional, Sabate-Fernandez, M., additional, De Leon, G., additional, Garcia-Dorado, D., additional, Castell-Conesa, J., additional, Candell-Riera, J., additional, Casset-Senon, D., additional, Edjlali-Goujon, M., additional, Alison, D., additional, Delhommais, A., additional, Cosnay, P., additional, Low, C. S., additional, Notghi, A., additional, O'brien, J., additional, Tweddel, A. C., additional, Bingham, N., additional, O Neil, P., additional, Harbinson, M., additional, Lindner, O., additional, Burchert, W., additional, Schaefers, M., additional, Marcassa, C., additional, Campini, R., additional, Calza, P., additional, Zoccarato, O., additional, Kisko, A., additional, Kmec, J., additional, Babcak, M., additional, Vereb, M., additional, Vytykacova, M., additional, Cencarik, J., additional, Gazdic, P., additional, Stasko, J., additional, Abreu, A., additional, Pereira, E., additional, Oliveira, L., additional, Colarinha, P., additional, Veloso, V., additional, Enriksson, I., additional, Proenca, G., additional, Delgado, P., additional, Rosario, L., additional, Sequeira, J., additional, Kosa, I., additional, Vassanyi, I., additional, Egyed, C. S., additional, Kozmann, G. Y., additional, Morita, S., additional, Nanasato, M., additional, Nanbu, I., additional, Yoshida, Y., additional, Hirayama, H., additional, Allam, A., additional, Sharef, A., additional, Shawky, I., additional, Farid, M., additional, Mouden, M., additional, Ottervanger, J. P., additional, Timmer, J. R., additional, De Boer, M. J., additional, Reiffers, S., additional, Jager, P. L., additional, Knollema, S., additional, Nasr, G. M., additional, Mohy Eldin, M., additional, Ragheb, M., additional, Casans-Tormo, I., additional, Diaz-Exposito, R., additional, Hurtado-Mauricio, F. J., additional, Ruano, R., additional, Diego, M., additional, Gomez-Caminero, F., additional, Albarran, C., additional, Martin De Arriba, A., additional, Rosero, A., additional, Lopez, R., additional, Martin Luengo, C., additional, Garcia-Talavera, J. R., additional, Laitinen, I. E. K., additional, Rudelius, M., additional, Weidl, E., additional, Henriksen, G., additional, Wester, H. J., additional, Schwaiger, M., additional, Pan, X. B., additional, Schindler, T., additional, Quercioli, A., additional, Zaidi, H., additional, Ratib, O., additional, Declerck, J. M., additional, Alexanderson Rosas, E., additional, Jacome, R., additional, Jimenez-Santos, M., additional, Romero, E., additional, Pena-Cabral, M. A., additional, Meave, A., additional, Gonzalez, J., additional, Rouzet, F., additional, Bachelet, L., additional, Alsac, J. M., additional, Suzuki, M., additional, Louedec, L., additional, Petiet, A., additional, Chaubet, F., additional, Letourneur, D., additional, Michel, J. B., additional, Le Guludec, D., additional, Aktas, A., additional, Cinar, A., additional, Yaman, G., additional, Bahceci, T., additional, Kavak, K., additional, Gencoglu, A., additional, Jimenez-Heffernan, A., additional, Sanchez De Mora, E., additional, Lopez-Martin, J., additional, Lopez-Aguilar, R., additional, Ramos, C., additional, Salgado, C., additional, Ortega, A., additional, Sanchez-Gonzalez, C., additional, Roa, J., additional, Tobaruela, A., additional, Nesterov, S. V., additional, Turta, O., additional, Maki, M., additional, Han, C., additional, Daou, D., additional, Tawileh, M., additional, Chamouine, S. O., additional, Coaguila, C., additional, Mariscal-Labrador, E., additional, Kisiel-Gonzalez, N., additional, De Araujo Goncalves, P., additional, Sousa, P. J., additional, Marques, H., additional, O'neill, J., additional, Pisco, J., additional, Cale, R., additional, Brito, J., additional, Gaspar, A., additional, Machado, F. P., additional, Roquette, J., additional, Martinez, M., additional, Melendez, G., additional, Kimura, E., additional, Ochoa, J. M., additional, Alessio, A. M., additional, Patel, A., additional, Lautamaki, R., additional, Bengel, F. M., additional, Bassingthwaighte, J. B., additional, Caldwell, J. H., additional, Rahbar, K., additional, Seifarth, H., additional, Schafers, M., additional, Stegger, L., additional, Spieker, T., additional, Hoffmeier, A., additional, Maintz, D., additional, Scheld, H., additional, Schober, O., additional, Weckesser, M., additional, Aoki, H., additional, Matsunari, I., additional, Kajinami, K., additional, Martin Fernandez, M., additional, Barreiro Perez, M., additional, Fernandez Cimadevilla, O. V., additional, Leon Duran, D., additional, Velasco Alonso, E., additional, Florez Munoz, J. P., additional, Luyando, L. H., additional, Templin, C., additional, Veltman, C. E., additional, Reiber, J. H. C., additional, Venuraju, S., additional, Yerramasu, A., additional, Atwal, S., additional, Lahiri, A., additional, Kunimasa, T., additional, Shiba, M., additional, Ishii, K., additional, Aikawa, J., additional, Kroner, E. S. J., additional, Ho, K. T., additional, Yong, Q. W., additional, Chua, K. C., additional, Panknin, C., additional, Roos, C. J., additional, Van Werkhoven, J. M., additional, Witkowska-Grzeslo, A. J., additional, Boogers, M. J., additional, Anand, D. 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C., additional, Genovesi, D., additional, Giorgetti, A., additional, Gimelli, A., additional, Cannizzaro, G., additional, Bertagna, F., additional, Fagioli, G., additional, Rossi, M., additional, Bonini, R., additional, Marzullo, P., additional, Paterson, C. A., additional, Smith, S. A., additional, Small, A. D., additional, Goodfield, N. E. R., additional, Martin, W., additional, Nekolla, S., additional, Sherif, H., additional, Reder, S., additional, Yu, M., additional, Kusch, A., additional, Li, D., additional, Zou, J., additional, Lloyd, M. S., additional, Cao, K., additional, Motherwell, D. W., additional, Rice, A., additional, Mccurrach, G. M., additional, Cobbe, S. M., additional, Petrie, M. C., additional, Al Younis, I., additional, Van Der Wall, E., additional, Mirza, T., additional, Raza, M., additional, Hashemizadeh, H., additional, Santos, L., additional, Krishna, B. A., additional, Perna, F., additional, Lago, M., additional, Leo, M., additional, Pelargonio, G., additional, Bencardino, G., additional, Narducci, M. L., additional, Casella, M., additional, Bellocci, F., additional, Kirac, S., additional, Yaylali, O., additional, Serteser, M., additional, Yaylali, T., additional, Okizaki, A., additional, Urano, Y., additional, Nakayama, M., additional, Ishitoya, S., additional, Sato, J., additional, Ishikawa, Y., additional, Sakaguchi, M., additional, Nakagami, N., additional, Aburano, T., additional, Solav, S. V., additional, Bhandari, R., additional, Burrell, S., additional, Dorbala, S., additional, Bruno, I., additional, Caldarella, C., additional, Collarino, A., additional, Mattoli, M. V., additional, Stefanelli, A., additional, Cannarile, A., additional, Maggi, F., additional, Soukhov, V., additional, Bondarev, S., additional, Yalfimov, A., additional, Khan, M., additional, Priyadharshan, P. P., additional, Chandok, G., additional, Aziz, T., additional, Avison, M., additional, Smith, R. A., additional, Bulugahapitya, D. S., additional, Vakhtangadze, T., additional, Todua, F., additional, Baramia, M., additional, Antelava, G., additional, Roche, N.- C., additional, Paule, P., additional, Kerebel, S., additional, Gil, J.- M., additional, Fourcade, L., additional, Tzonevska, A., additional, Tzvetkov, K., additional, Atanasova, M., additional, Parvanova, V., additional, Chakarova, A., additional, Piperkova, E., additional, Kocabas, B., additional, Muderrisoglu, H., additional, Allaart, C. P., additional, Entok, E., additional, Simsek, S., additional, Akcay, B., additional, Ak, I., additional, Vardareli, E., additional, Stachura, M., additional, Kwasiborski, P. J., additional, Horszczaruk, G. J., additional, Komar, E., additional, Cwetsch, A., additional, Zraik, B., additional, Morales Demori, R., additional, Almeida, A. D. J., additional, Siqueira, M. E., additional, Vieira, E., additional, Balogh, I., additional, Kerecsen, G., additional, Marosi, E., additional, Szelid, Z. S., additional, Sattar, A., additional, Swadia, T., additional, Chattahi, J., additional, Qureshi, W., additional, Khalid, F., additional, Gonzalez, A., additional, Hechavarria, S., additional, Takamura, K., additional, Fujimoto, S., additional, Nakanishi, R., additional, Yamashina, S., additional, Namiki, A., additional, Yamazaki, J., additional, Koshino, K., additional, Hashikawa, Y., additional, Teramoto, N., additional, Hikake, M., additional, Ishikane, S., additional, Ikeda, T., additional, Iida, H., additional, Takahashi, Y., additional, Oriuchi, N., additional, Higashino, H., additional, Endo, K., additional, Mochizuki, T., additional, Murase, K., additional, Baali, A., additional, Moreno, R., additional, Chau, M., additional, Rousseau, H., additional, Nicoud, F., additional, Dolliner, P., additional, Brammen, L., additional, Steurer, G., additional, Traub-Weidinger, T., additional, Ubl, P., additional, Schaffarich, P., additional, Dobrozemsky, G., additional, Staudenherz, A., additional, Ozgen Kiratli, M., additional, Temelli, B., additional, Kanat, N. B., additional, Aksoy, T., additional, Slavich, G. A., additional, Piccoli, G., additional, Puppato, M., additional, Grillone, S., additional, Gasparini, D., additional, Dunet, V., additional, Perruchoud, S., additional, Poitry-Yamate, C., additional, Lepore, M., additional, Gruetter, R., additional, Pedrazzini, T., additional, Anselm, D., additional, Anselm, A., additional, Atkins, H., additional, Renaud, J., additional, Dekemp, R., additional, Burwash, I., additional, Guo, A., additional, Beanlands, R., additional, Glover, C., additional, Vilardi, I., additional, Zangheri, B., additional, Calabrese, L., additional, Romano, P., additional, Bruno, A., additional, Fernandez Cimadevilla, O. C., additional, Uusitalo, V. A., additional, Luotolahti, M., additional, Wendelin-Saarenhovi, M., additional, Sundell, J., additional, Raitakari, O., additional, Huidu, S., additional, Gadiraju, R., additional, Ghesani, M., additional, Uddin, Q., additional, Wosnitzer, B., additional, Takahashi, N., additional, Alhaj, E., additional, Legasto, A., additional, Abiri, B., additional, Elsaban, K., additional, El Khouly, T., additional, El Kammash, T., additional, Al Ghamdi, A., additional, Kyung Deok, B., additional, Bon Seung, K., additional, Sang Geun, Y., additional, Chang Min, D., additional, and Gwan Hong, M., additional more...
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- 2011
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16. 40: Changes In the Neurohormonal Profile of Patients Hospitalized for Acute Heart Failure Syndromes During the Early Post-Discharge Period According to Early, Late, or No Heart Failure Re-Hospitalization or Mortality Events: Analysis From the EVEREST Trials
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Pang, P.S., primary, Zannad, F., additional, Konstam, M., additional, Burnett, J., additional, Udelson, J., additional, Swedberg, K., additional, Grinfeld, L., additional, Maggioni, A.P., additional, Cook, T., additional, and Gheorghiade, M., additional more...
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- 2010
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17. PCV127 EFFECT OF TOLVAPTAN ON HOSPITAL LENGTH OF STAY (LOS) WITHIN HYPONATREMIC PATIENTS HOSPITALIZED FOR HEART FAILURE
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Cyr, PL, primary, Slawsky, K, additional, Olchanski, N, additional, Krasa, H, additional, Zimmer, C, additional, Ouyang, J, additional, Goss, TF, additional, Udelson, J, additional, and Hauptman, PL, additional more...
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- 2009
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18. PCV125 EVALUATION OF THE ASSOCIATION BETWEEN SERUM SODIUM AND LENGTH OF STAY (LOS) IN PATIENTS HOSPITALIZED FOR HEART FAILURE
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Cyr, PL, primary, Slawsky, K, additional, Olchanski, N, additional, Krasa, H, additional, Zimmer, C, additional, Ouyang, J, additional, Goss, TF, additional, Udelson, J, additional, and Hauptman, PL, additional more...
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- 2009
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19. Design, rationale, and populations of an international outcomes and utilization study of pharmacologic stress SPECT myocardial perfusion imaging in contemporary practice
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JOHNSON, J, primary, BARRETT, R, additional, HACHAMOVITCH, R, additional, UDELSON, J, additional, MASSARO, J, additional, and JENKINS, S, additional
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- 2008
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20. 15.27: Double-blinded comparison of the side effects associated with pharmacologic stress induced with binodenoson and adenosine
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UDELSON, J, primary, ITELD, B, additional, WEILAND, F, additional, FOSTER, J, additional, BONOW, R, additional, FICARO, E, additional, GIBBONS, R, additional, HELLER, G, additional, WACKERS, F, additional, and BARRETT, R, additional more...
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- 2008
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21. Prognostic value and changes in renal function in patients admitted with acute heart failure - results from the EVEREST program
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BLAIR, J, primary, BURNETT, J, additional, KONSTAM, M, additional, MAGGIONI, A, additional, SWEDBERG, K, additional, UDELSON, J, additional, ZANNAD, F, additional, COOK, T, additional, FILIPPATOS, G, additional, and GHEORGHIADE, M, additional more...
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- 2008
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22. Regional differences in baseline characteristics and outcomes in patients admitted with acute heart failure - results from the EVEREST program
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BLAIR, J, primary, ZANNAD, F, additional, KONSTAM, M, additional, COOK, T, additional, BURNETT, J, additional, GRINFIELD, L, additional, MAGGIONI, A, additional, SWEDBERG, K, additional, UDELSON, J, additional, and GHEORGHIADE, M, additional more...
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- 2008
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23. 597. Dose-finding study of tolvaptan in heart failure: comparison of two doses and dosing regimens of tolvaptan in congestive heart failure
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Hauptman, P.J., Zimmer, C., and Udelson, J.
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Health - Published
- 2006
24. Eighth Nuclear Cardiology Invitational Conference Park City, Utah, 2006
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CERQUEIRA, M, primary, GARCIA, E, additional, GROPLER, R, additional, and UDELSON, J, additional
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- 2007
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25. Future directions of myocardial fatty acid imaging
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PASTORE, C, primary, BABICH, J, additional, and UDELSON, J, additional
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- 2007
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26. The price for probability: Comparing the costs of diagnostic testing strategies
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SOMAN, P, primary and UDELSON, J, additional
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- 2007
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27. Vascular endothelial dysfunction is associated with reversible myocardial perfusion defects in the absence of obstructive coronary artery disease
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SOMAN, P, primary, DAVE, D, additional, UDELSON, J, additional, HAN, H, additional, OUDA, H, additional, PATEL, A, additional, KARAS, R, additional, and KUVIN, J, additional
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- 2006
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28. Seventh Nuclear Cardiology Invitational Conference, Park City, Utah, 2004
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CERQUEIRA, M, primary and UDELSON, J, additional
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- 2005
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29. Screening the population for coronary artery disease: Is it like screening for cancer?
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SOMAN, P, primary and UDELSON, J, additional
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- 2005
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30. Distribution of ischemia and fixed perfusion defects detected in an international, observational, study of pharmacologic stress spect myocardial perfusion imaging
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UDELSON, J, primary
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- 2004
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31. The historical and conceptual evolution of radionuclide assessment of myocardial viability
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UDELSON, J, primary
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- 2004
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32. Radionuclide imaging in heart failure: Assessing etiology and outcomes and implications for management
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UDELSON, J, primary, SHAFER, C, additional, and CARRIO, I, additional
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- 2002
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33. Prologue: Putting the horse before the cart
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NARULA, J, primary, UDELSON, J, additional, and CERQUEIRA, M, additional
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- 2002
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34. 15.1 Prognostic impact of myocardial viability testing in 3088 patients: a meta-analysis 1992–1999
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ALLMAN, K, primary, SHAW, L, additional, HACHAMOVITCH, R, additional, and UDELSON, J, additional
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- 2001
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35. American Society of Nuclear Cardiology position statement on electrocardiographic gating of myocardial perfusion SPECT scintigrams
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BATEMAN, T, primary, BERMAN, D, additional, HELLER, G, additional, BROWN, K, additional, CERQUEIRA, M, additional, VERANI, M, additional, and UDELSON, J, additional
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- 1999
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36. Improved detection of reversible ischaemia by Tc-99m sestamibi compared to Tc-99m tetrofosmin SPECT imaging in mild to moderate coronary artery disease
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Soman, P, primary, Taillefer, R, additional, Depuey, G.E, additional, Udelson, J, additional, and Lahiri, A, additional
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- 1999
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37. Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc-sestamibi.
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Udelson, J E, primary, Coleman, P S, additional, Metherall, J, additional, Pandian, N G, additional, Gomez, A R, additional, Griffith, J L, additional, Shea, N L, additional, Oates, E, additional, and Konstam, M A, additional more...
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- 1994
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38. A new noninvasive method for the estimation of peak dP/dt.
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Rhodes, J, primary, Udelson, J E, additional, Marx, G R, additional, Schmid, C H, additional, Konstam, M A, additional, Hijazi, Z M, additional, Bova, S A, additional, and Fulton, D R, additional
- Published
- 1993
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39. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD (Studies of Left Ventricular Dysfunction) Investigators.
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Konstam, M A, primary, Kronenberg, M W, additional, Rousseau, M F, additional, Udelson, J E, additional, Melin, J, additional, Stewart, D, additional, Dolan, N, additional, Edens, T R, additional, Ahn, S, additional, and Kinan, D, additional more...
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- 1993
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40. Effects of long-term enalapril therapy on left ventricular diastolic properties in patients with depressed ejection fraction. SOLVD Investigators.
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Pouleur, H, primary, Rousseau, M F, additional, van Eyll, C, additional, Stoleru, L, additional, Hayashida, W, additional, Udelson, J A, additional, Dolan, N, additional, Kinan, D, additional, Gallagher, P, additional, and Ahn, S, additional more...
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- 1993
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41. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. SOLVD Investigators.
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Konstam, M A, primary, Rousseau, M F, additional, Kronenberg, M W, additional, Udelson, J E, additional, Melin, J, additional, Stewart, D, additional, Dolan, N, additional, Edens, T R, additional, Ahn, S, additional, and Kinan, D, additional more...
- Published
- 1992
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42. Impact of surgical relief of outflow obstruction on thallium perfusion abnormalities in hypertrophic cardiomyopathy.
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Cannon, R O, primary, Dilsizian, V, additional, O'Gara, P T, additional, Udelson, J E, additional, Tucker, E, additional, Panza, J A, additional, Fananapazir, L, additional, McIntosh, C L, additional, Wallace, R B, additional, and Bonow, R O, additional more...
- Published
- 1992
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43. A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial.
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Gheorghiade M, Pang PS, Ambrosy AP, Lan G, Schmidt P, Filippatos G, Konstam M, Swedberg K, Cook T, Traver B, Maggioni A, Burnett J, Grinfeld L, Udelson J, Zannad F, Gheorghiade, Mihai, Pang, Peter S, Ambrosy, Andrew P, Lan, Gloria, and Schmidt, Philip more...
- Abstract
Hospitalization for worsening chronic heart failure results in high post-discharge mortality, morbidity, and cost. However, thorough characterization, soon after discharge of patients with early post-discharge events has not been previously performed. The objectives of this study were to describe the baseline, in-hospital, and post-discharge clinical, laboratory, and neurohormonal profiles of patients hospitalized for worsening heart failure with reduced ejection fraction (EF) who die or are re-admitted for cardiovascular (CV) causes within 90 days of initial hospitalization. Retrospective analysis of 4,133 patients hospitalized for worsening heart failure with EF ≤40% in the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial, which randomized patients to tolvaptan or placebo, both in addition to standard therapy. Clinical and laboratory parameters were obtained within 48 h of admission, during hospitalization, and post-discharge weeks 1, 4, 8, and every 8 weeks thereafter for a median of 9.9 months. Patients with events within 90 days were compared with those with later/no events. All-cause mortality (ACM) and CV re-hospitalization were independently adjudicated. Within 90 days of admission, 395 patients (9.6%) died and 801 patients (19.4%) were re-hospitalized for CV causes. Significant baseline and longitudinal differences were seen between groups with early versus later (>90 days) or no events at 12 months post-randomization. Post-discharge outcomes were similar in the tolvaptan and placebo groups. Patients with early post-discharge events experienced clinically significant worsening in signs and symptoms, laboratory values, and neurohormonal parameters soon after discharge. Identifying these abnormalities may facilitate efforts to reduce post-discharge mortality and re-hospitalization. [ABSTRACT FROM AUTHOR] more...
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- 2012
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44. Left ventricular diastolic collapse. An echocardiographic sign of regional cardiac tamponade.
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Chuttani, K, primary, Pandian, N G, additional, Mohanty, P K, additional, Rosenfield, K, additional, Schwartz, S L, additional, Udelson, J E, additional, Simonetti, J, additional, Kusay, B S, additional, and Caldeira, M E, additional more...
- Published
- 1991
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45. Myocardial metabolic, hemodynamic, and electrocardiographic significance of reversible thallium-201 abnormalities in hypertrophic cardiomyopathy.
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Cannon, R O, primary, Dilsizian, V, additional, O'Gara, P T, additional, Udelson, J E, additional, Schenke, W H, additional, Quyyumi, A, additional, Fananapazir, L, additional, and Bonow, R O, additional more...
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- 1991
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46. Minimum left ventricular pressure during beta-adrenergic stimulation in human subjects. Evidence for elastic recoil and diastolic "suction" in the normal heart.
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Udelson, J E, primary, Bacharach, S L, additional, Cannon, R O, additional, and Bonow, R O, additional
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- 1990
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47. Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure.
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Udelson, J E, Smith, W B, Hendrix, G H, Painchaud, C A, Ghazzi, M, Thomas, I, Ghali, J K, Selaru, P, Chanoine, F, Pressler, M L, and Konstam, M A
- Published
- 2001
48. Therapeutic angiogenesis with recombinant fibroblast growth factor-2 improves stress and rest myocardial perfusion abnormalities in patients with severe symptomatic chronic coronary artery disease.
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Udelson, J E, Dilsizian, V, Laham, R J, Chronos, N, Vansant, J, Blais, M, Galt, J R, Pike, M, Yoshizawa, C, and Simons, M
- Published
- 2000
- Full Text
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49. Comparison between the end-diastolic images and the summed images of gated 99mTc-sestamibi SPECT perfusion study in detection of coronary artery disease in women.
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Taillefer, Raymond, DePuey, E., Udelson, James, Beller, George, Benjamin, Carole, Gagnon, Andre, Taillefer, R, DePuey, E G, Udelson, J E, Beller, G A, Benjamin, C, and Gagnon, A
- Abstract
Background: End-diastolic images (EDI) can be easily derived from technetium 99m-sestamibi gated single photon emission computed tomography (SPECT) perfusion study (SGS). This may reduce the effect of myocardial wall thickening during systole and potentially improve the sensitivity of radionuclide perfusion imaging, especially in patients with small hearts.Methods: This prospective study was conducted in 53 consecutive female patients to compare the diagnostic accuracy of EDI with that of the summed images (SI) of SGS. Fifty-three patients with suspected coronary artery disease (CAD), scheduled for coronary angiography within 2 months, were evaluated with SGS. Treadmill stress testing was used in 28 patients, and dipyridamole injection was used in the remaining 25 patients. A 2-day protocol was used as follows: stress test with 25 to 30 mCi of 99mTc-sestamibi and a rest study performed at least 24 hours later with the same dose. Sixteen frames per cardiac cycle were acquired for both the rest and the stress studies. Three end-diastolic frames were used for EDI, and all the 16 frames were summed for SI. SI and EDI data reconstruction were interpreted by 3 experienced blinded observers (consensus reading) during two distinct reading sessions, one with SI alone and the second with EDI alone. The heart was divided into 17 segments.Results: Coronary angiography showed > or = 50% stenoses in 1 or more major coronary arteries in 38 patients and was normal in 15 patients. The sensitivity was 73.7% (28/38) and 84.2% (32/38), respectively, for SI and EDI. Three of 4 patients with CAD not detected by SI but seen with EDI were considered to have relatively small hearts. The specificity was 86.7% (13/15) and 80.0% (12/15) for SI and EDI, respectively. On a total of 901 segments, 106 ischemic defects were detected by SI and 173 by EDI (P = .001). The segmental agreement between the two techniques was 88.6% (798/901 segments).Conclusion: EDI showed more ischemic defects than SI, and there was also a nonsignificant trend toward an improved sensitivity of EDI in comparison to SI in detection of coronary artery disease in women, especially in patients with small hearts. EDI may be a useful adjunct to the standard perfusion imaging with SGS in such a clinical situation. [ABSTRACT FROM AUTHOR] more...- Published
- 1999
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- View/download PDF
50. Left ventricular diastolic dysfunction as a cause of congestive heart failure. Mechanisms and management.
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Bonow, Robert O., Udelson, James E., Bonow, R O, and Udelson, J E
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CONGESTIVE heart failure ,HEART failure ,DIASTOLE (Cardiac cycle) ,LEFT heart ventricle ,HEART physiology - Abstract
Objective: To define the mechanisms underlying left ventricular diastolic dysfunction in patients with congestive heart failure and normal systolic function and to identify the patients at risk for this syndrome.Study Selection: Studies were selected that describe the clinical observations of congestive heart failure with normal systolic function and that provide experimental and clinical insights into the mechanisms responsible for ventricular diastolic dysfunction.Data Synthesis: Recent studies indicate that a large number of patients (up to 40% in some series) presenting with congestive heart failure have preserved left ventricular systolic function. The factors contributing to altered left ventricular diastolic function include fibrosis, hypertrophy, ischemia, and increased afterload. The latter three factors, alone or in combination, predispose to impaired left ventricular relaxation, an active energy-requiring process. Thus, decreased left ventricular diastolic distensibility (increased diastolic pressure at any level of diastolic volume) may arise not only from altered passive elastic properties stemming from fibrosis or increased muscle mass but also from derangements in the dynamics of ventricular relaxation.Results: In patients with essential hypertension, all four of the above mechanisms may be operative. Considering the prevalence of hypertension in the general population, hypertension appears to be an important underlying factor in many patients with heart failure on the basis of diastolic mechanisms. In the patient presenting with dyspnea and elevated filling pressures, but with a nondilated, normally contracting ventricle, treatment with standard heart failure medications (such as digitalis, diuretics, and vasodilators) is often ineffective and may be deleterious. Such patients may respond more favorably to beta-blockers and calcium-channel blockers.Conclusions: Diastolic dysfunction should be considered in the patient presenting with heart failure symptoms but with normal systolic function, particularly in hypertensive patients with left ventricular hypertrophy. [ABSTRACT FROM AUTHOR] more...- Published
- 1992
- Full Text
- View/download PDF
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