Search

Micellescan be formed from coenzyme Q10(CoQ10) anddipotassium glycyrrhizate (GZK2) by using an inclusioncomplex of CoQ10with γ-cyclodextrin (γ-CD).The mechanism of micelle formation was kinetically investigated. AddingGZK2to a supersaturated solution of the CoQ10/γ-CD inclusion complex led to a linear increase in the solubilityof CoQ10due to the formation of micelles of CoQ10when the molar ratio of GZK2/γ-CD increased to∼1.6, after which the concentration remained constant. Theequilibrium constant Kfor micelle formation was0.68 (−) and the ratio of GZK2to CoQ10was 1. These results suggest that the formation of CoQ10micelles with GZK2might proceed via the displacementof CoQ10by GZK2in the γ-CD cavity followedby the formation of CoQ10micelles. [ABSTRACT FROM AUTHOR]

Abstract: We previously reported the bioavailability enhancement of lipophilic Coenzyme Q10 (CoQ10) by complexing with γ- Cyclodextrin (γCD). Here, we report on its mechanism. Hydrophobic CoQ10 generally agglutinates but the dissociated CoQ10 from γCD was captured by bile acid to form nanometer molecular micelle without aggregation and therefore both solubility and bioavailability could be enhanced. Furthermore, we succeeded in the expansion of this finding to personal care field by the use of Dipotassium glycyrrhizate (GZK2) instead of bile acid. The skin absorptions of actives could be significantly enhanced by the combination of cosme-ceutical-γCD complexes with GZK2. [Copyright &y& Elsevier]

To determine the bioavailability of tocotrienol complex with gamma-cyclodextrin, the effects of tocotrienol/gamma-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. At 3 h after administration, the plasma gamma-tocotrienol concentration of the rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the rats administered tocotrienol and gamma-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. The plasma gamma-tocotrienol concentration of the Triton-treated rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with gamma-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.