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4. Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia–reperfusion injury

Author

Tan, Can, primary, Norden, Pieter R, additional, Yu, Wei, additional, Liu, Ting, additional, Ujiie, Naoto, additional, Lee, Sun Kyong, additional, Yan, Xiaocai, additional, Dyakiv, Yaryna, additional, Aoto, Kazushi, additional, Ortega, Sagrario, additional, De Plaen, Isabelle G, additional, Sampath, Venkatesh, additional, and Kume, Tsutomu, additional

Published
2023
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9. A potential preventive method for scar stenosis after esophageal endoscopic mucosal resection using human amniotic epithelial cells in a porcine model

Author

Konno, Yuji, primary, Sato, Chiaki, additional, Tokodai, Kazuaki, additional, Saito, Masatoshi, additional, Hoshiai, Tetsuro, additional, Taniyama, Yusuke, additional, Okamoto, Hiroshi, additional, Fukutomi, Toshiaki, additional, Ozawa, Yohei, additional, Ujiie, Naoto, additional, Koseki, Ken, additional, Ando, Ryohei, additional, Takahashi, Kozue, additional, Shinozaki, Yasuharu, additional, Unno, Michiaki, additional, and Kamei, Takashi, additional

Published
2022
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11. Differential roles of neural crest- and endothelial-derived FOXC2 in trabecular meshwork and Schlemm’s Canal in glaucomatous pathology

Author

Norden, Pieter R, primary, Beckmann, Lisa, additional, Fang, Raymond, additional, Ujiie, Naoto, additional, Cai, Zhen, additional, Zhang, Xian, additional, Kweon, Junghun, additional, Liu, Ting, additional, Aoto, Kazushi, additional, Quaggin, Susan E, additional, Zhang, Hao F., additional, and Kume, Tsutomu, additional

Published
2022
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14. Geriatric patients with esophageal motility disorders benefit more from minimally invasive peroral endoscopic myotomy: a multicenter study in Japan.

Author

Ujiie, Naoto, Sato, Hiroki, Fujiyoshi, Mary Raina Angeli, Tanaka, Shinwa, Shiwaku, Hironari, Shiota, Junya, Ogawa, Ryo, Yokomichi, Hiroshi, Kamei, Takashi, and Inoue, Haruhiro

Subjects
*ESOPHAGEAL motility disorders, *CHEST pain, *GASTROESOPHAGEAL reflux, *MYOTOMY, *ESOPHAGEAL achalasia
Abstract

Geriatric patients with existing studies on the safety and efficacy of peroral endoscopic myotomy (POEM) for achalasia involve small sample sizes and single institutions. However, multi-center, large-scale data analyses are lacking. The study aimed to clarify the characteristics of geriatric patients with esophageal motility disorders (EMDs) and determine the procedure-related outcomes and clinical course following POEM. This cohort study included 2,735 patients with EMDs who were treated at seven Japanese facilities between 2010 and 2019. The patients' characteristics and post-POEM clinical courses were compared between the geriatric (age ≥ 75 years; n  = 321) and non-geriatric (age < 75 years; n  = 2,414) groups. Compared with the non-geriatric group, the geriatric group had higher American Society of Anesthesiologists physical status scores; more recurrent cases; lower incidence of chest pain; and higher incidence of type III achalasia, distal esophageal spasm, and Jackhammer esophagus. Furthermore, the incidence of sigmoid esophagus was higher, although esophageal dilation was not severe in this group. POEM was safe and effective for geriatric patients with treatment-naïve and recurrent EMDs. Furthermore, compared with the non-geriatric group, the geriatric group had lower post-POEM Eckardt scores, fewer complaints of refractory chest pain, and a lower incidence rate of post-POEM reflux esophagitis. Geriatric patients are characterized by worse clinical conditions, more spastic disorders, and greater disease progression of EMDs, which are also the indications for minimally invasive POEM. POEM is more beneficial in geriatric patients as it has lowering symptom scores and incidence rates of reflux esophagitis. [ABSTRACT FROM AUTHOR]

Published
2022
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16. P24 TREATMENT FOR RECURRENT ESOPHAGEAL SQUAMOUS CELL CARCINOMA AFTER CURATIVE ESOPHAGECTOMY

Author

Oikawa Takahiro, Sato Chiaki, Takaya Kai, Ujiie Naoto, Okamoto Hiroshi, Taniyama Yusuke, Fukutomi Toshiaki, Konno-Kumagai Takuro, and Kamei Takashi

Subjects
medicine.medical_specialty, business.industry, Esophagectomy, Internal medicine, medicine.medical_treatment, Gastroenterology, Medicine, Recurrent Esophageal Squamous Cell Carcinoma, General Medicine, business
Abstract

Aim The aim is to find out what treatment should be chosen at the time of recurrence of the esophageal squamous cell carcinoma (ESCC) after curative esophagectomy. Background & Methods ESCC patients with recurrence after curative resection have extremely poor survival rates. However, long-term survival cases and complete cure cases have also been reported. We retrospectively evaluated 184 patients with recurrent ESCC after curative esophagectomy between 2001 and 2015. Results M/F: 148/36, Median age: 64(36-84), Location: Upper third/Middle/Lower: 18/105/61, Pretreatment: None/Neoadjuvant chemotherapy/Neoadjuvant chemoradiotherapy (CRT)/Definitive CRT: 79/42/30/33, pT0/1/2/3/4: 3/39/18/119/5, pN0/1/2/3: 51/59/51/22, pStage1/2/3/4: 24/51/95/14 (UICC 7th), Recurrence site: Lymph node 124 (67%) [cervical 35 (19%), mediastinum 82 (45%), abdomen 35 (19%)], lung 36 (20%), liver 32 (17%), pleura 18 (10%), bone 13 (7%), brain 3 (1.6%), peritoneum 3, skin 2 (1.1%) adrenal 2, residual esophagus 1 (0.5%), gastric tube 1, colon 1, kidney 1, testis 1. First treatment after recurrence: Surgery/CRT/chemotherapy/Best Supportive Care (BSC): 8/89/64/23. Regarding to overall survival after recurrence by the treatment groups, there was a significant difference between all groups; surgery (median 61 months) > CRT (17) > chemotherapy (9) > BSC (1). Surgery was performed to the patients with solitary lesion (lung 3, cervical lymph node 3, descending colon 1, brain 1). Prognosis of the patients with single-organ recurrence was better than that of those with multi-organ recurrence only in CRT group, and prognosis of the patients without pretreatment was better than that of those with pretreatment only in chemotherapy group. Regarding to the time from esophagectomy to recurrence, the patients with the duration of 6 months or more had a good prognosis compared with those with less than 6 months only in CRT group. Conclusion As treatment for recurrent ESCC after curative esophagectomy, some treatment may be recommended as much as possible. Priority is given in the order of Surgery > CRT > Chemotherapy. Surgery may be recommended for the patients with solitary recurrence of lung or cervical Lymph nodes. CRT may be recommended for the patients with single-organ recurrence, at least six months after esophagectomy. Chemotherapy may be recommended for the patients without preoperative treatment.

Published
2019

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