142 results on '"Ukkonen, H"'
Search Results
2. Outcome of transcatheter atrial septal defect closure in a nationwide cohort.
- Author
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Muroke, V., Jalanko, M., Haukka, J., Hartikainen, J., Tahvanainen, A., Ukkonen, H., Ylitalo, K., Pihkala, J., and Sinisalo, J.
- Subjects
ATRIAL septal defects ,CORONARY disease ,HEART failure ,MYOCARDIAL ischemia ,VENTRICULAR fibrillation ,ATRIAL fibrillation ,ARRHYTHMIA ,THERAPEUTIC embolization - Abstract
Transcatheter (TC) atrial septal defect (ASD) closure has been the mainstay of therapy for secundum-type ASDs for over 20 years. This nationwide cohort evaluated the long-term outcome of transcatheter-closed ASDs. The study enrolled every transcatheter ASD closure performed in Finland from 1999 to 2019. Five age, sex, and municipality-matched controls per ASD patient were gathered from the general population. The median follow-up period was 5.9 years (range 0–20.8). We used the hospital discharge register to gather all hospital visits and diagnoses. Closure complications and echocardiographic changes were collected from the electronic health records. Transcatheter ASD closure was performed in 1000 patients (68.5% females) during the study period. The median (range) age at the time of the procedure was 37.9 (1.8–87.5) years. ASD patients had an increased risk for new-onset atrial fibrillation (RR 2.45, 95% CI: 1.84–3.25), migraine (RR 3.61, 95% CI: 2.54–5.14), ischemic heart disease (RR 1.73, 95% CI: 1.23–2.45), ventricular fibrillation/tachycardia (RR 3.54 (95% CI: 1.48–8.43) and AV conduction disorder (RR 3.60, 95% CI: 1.94–6.70) compared to the control cohort. Stroke risk was not increased (RR 1.36, 95% CI: 0.91–2.03). Adverse events occurred in 6.3% (n = 63) of the patients, including four erosions and ten device embolizations. After TC closure of ASD, patients had a higher risk of new-onset atrial fibrillation and migraine than controls without ASD. As novel findings, we found an increased risk for ischemic heart disease, AV conduction disorders, and ventricular fibrillation/tachycardia. Even though patients have an excellent overall prognosis after percutaneous ASD closure, the increased incidence of major comorbidities like atrial fibrillation and heart failure prompts more thorough lifelong follow-up. This study's novel findings revealed the increased risk for ischemic heart disease, AV conduction disorders, or ventricular tachycardia/fibrillation during the follow-up. Major complications after the closure are rare; erosion is seen in 0.4% of the patients and embolization in 1.0% of the patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Changes in the microenvironment of invading melanoma and carcinoma cells identified by FTIR imaging
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Ukkonen, H., Kumar, S., Mikkonen, J., Salo, T., Singh, S.P., Koistinen, A.P., Goormaghtigh, E., and Kullaa, A.M.
- Published
- 2015
- Full Text
- View/download PDF
4. Outcome of device atrial septal defect closure in different age groups: a nationwide cohort study
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Muroke, V, primary, Jalanko, M, additional, Pihkala, J, additional, Hartikainen, J, additional, Tahvanainen, A, additional, Airaksinen, J, additional, Ukkonen, H, additional, Kervinen, K, additional, Ylitalo, K, additional, and Sinisalo, J, additional
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- 2022
- Full Text
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5. Effect of radiotherapy on expression of transmembrane mucin MUC1 in oral mucosal cells
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Ukkonen, H. (Helena), Kashyap, B. (Bina), Sirviö, E. (Ellinoora), Dekker, H. (Hannah), Vähänikkilä, H. (Hannu), Pirhonen, P. (Paula), Mikkonen, J. J. (Jopi J.W.), ten Bruggenkate, C. M. (Chris M), Schulten, E. A. (Engelbert AJM), Koistinen, A. (Arto), Bloemena, E. (Elisabeth), and Kullaa, A. M. (Arja M.)
- Subjects
mucosal pellicle ,oral epithelium ,mucins ,oral cancer ,radiotherapy - Abstract
Objective: Mucins form a protective surface called mucosal pellicle on oral epithelium. Mucin — 1 (MUC1) is secreted from the oral mucosal squamous epithelium itself on the apical surface of the epithelial cell. The objective of this study was to determine the effect of radiotherapy (RT) on MUC1 expression of the oral epithelium in patients with head and neck cancer (HNC). Methods: Oral mucosal tissue biopsies were obtained from 55 patients; Study group 1 consisted of 33 clinically healthy subjects as controls. The oncology group consisted of two subgroups: Group 2 consisted of 7 oral cancer patients treated with surgery without RT, and Group 3 consisted of 15 HNC patients treated with RT. To visualized MUC1 staining, HMFG1 antibody was used. In addition, microstructures of the specimens were studied under electron microscopies. Results: The superficial layer of the oral epithelium had strong MUC1 staining in control samples compared to oncological groups (p=0.002). Intermediate layer showed the most expression of MUC1 in irradiated mucosa (p=0.02). In both oncological groups, the expression of MUC1 was detected on the basal layer (p=0.005). Morphological analysis with electron microscopies showed destruction in the microstructure of apical cells of the irradiated oral epithelium. Irradiated oral mucosa with strong MUC1 expression showed loose intercellular bonds. Conclusion: Radiotherapy affects the expression of MUC1 in basal and intermediate layers of oral epithelium. Irradiation alters or hinders the intra and intercellular linkages which affects the normal apical transportation of MUC1 and hence, such alteration may play a role in promoting radiation — induced complications.
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- 2020
6. Posters display III clinical outcome and PET
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Baliño, N. Nestor Perez, Masoli, O., Traverso, S., Grynberg, L., Rappallo, C., Redruello, M., Rosa, D., Cragnolino, D., Meretta, A., Vidal, L., Graf, S., Khorsand, A. Aliasghar, Gyongyosi, M., Karanikas, G., Eidherr, H., Kletter, K., Porenta, G., Glogar, D., Sochor, H., Beheshti, M., Poetzi, C., Wadsak, W., Porenta, G., Maurer, G., Wolfram, J., Winter, O. Olivier De, Velghe, A., Veire, N. Van de, Bondt, P. De, Buyzere, M. De, Wiele, C. Van de, Backer, G. De, Gillebert, T. C., Dierckx, R. A., Sutter, J. De, Bernard, D., Langlois, M., Duarte, P. S. Paulo, Mastrocolla, L. E., Sampaio, C. R. E., Rossi, J. M., Smanio, P. E., Lima, E. V., Oliveira, C. A. R., Pereira, J. C. R., Smanio, P. Paola, Beraldo, P., Rodrigues, F., Thom, A., Yoshinaga, K. Keiichiro, Ukkonen, H., Burwash, I., DeKemp, R., Dafoe, W., Davies, R., Haddad, H., Ruddy, T., DaSilva, J., Beanlands, R., Chow, B., Williams, K., Garrard, L., Szeto, A., Aung, M., Sondergaard, H. Hanne, Bottcher, M., Madsen, M. M., Schmitz, O., Nielsen, T. T., Botker, H. E., Høilund-Carlsen, P. F. Poul F., Johansen, A., Christensen, H. W., Vach, W., Møldrup, M., Haghfelt, T., Johansen, A. Allan, Høilund-Carlsen, P. F., Christensen, H. W., Møldrup, M., Kristensen, J. Jens Hedega, Maeng, M., Mortensen, U. M., Berg, J. S., Rehling, M., Nielsen, T. T., Elsaban, K. Khaled, El-Kady, T., El-Gabaly, M., Yehia, A., El-Sayed, M., Naum, A. Alexandru, Laaksonen, M. S., Tuunanen, H., Oikonen, V., Kemppainen, J., Järvisalo, M. J., Nuutila, P., Knuuti, J., Vanzetto, G. Gerald, Jacon, P., Fagret, D., Machecourt, J., Lindner, O. Oliver, Vogt, J., Kammeier, A., Fricke, E., Wielepp, P., Baller, D., Lamp, B., Holzinger, J., Horstkotte, D., Burchert, W., Nekolla, S. G. Stephan, Souvatzoglou, M., Hausleiter, J., Henke, N., Kruschke, K., Bengel, F., Schwaiger, M., Sundaram, P. S. Palaniswamy Shanmuga, Padma, S., Haridas, K. K., Kumar, S., Zachariah, M., Livschitz, S. Shay, Zornitzki, T., Vered, S., Oettinger, M., Levy, R., Caspi, A., Faraggi, D., Knobler, H., Mats, I., Solodky, A., Ben-Gal, T., Battler, A., Zafrir, N. Nili, Varani, E. Elisabetta, Balducelli, M., Severi, S., Patroncini, A. L., Vecchi, G., Gatti, C., Corbelli, C., Casanova, R., Maresta, A., Cittanti, C. Corrado, Valgimigli, M., Giganti, M., Malagutti, P., Percoco, G., Bagatin, E., Panareo, S., Avigni, N., Ferrari, R., Feggi, L., Filardi, P. Pasquale Perrone, Cuocolo, A., Storto, G., Brevetti, G., Dellegrottaglie, S., Corrado, L., Cafiero, M., Polimeno, M., Zarrilli, A., Chiariello, M., Marcassa, C. Claudio, Campini, R., Calza, P., Giannuzzi, P., Galassi, A. R. Alfredo, Grasso, C., Azzarelli, S., Leotta, E., Moshiri, S., Tamburino, C., Acampa, W., Ferro, A., Petretta, M., Salvatore, M., Cuocolo, A. Alberto, Pieri, P. L. Pierluigi, Berta, R., Moscatelli, G., Buccoliero, F., Inglese, E., Marcassa, C. Claudio, Medolago, G., Imperiale, A., Rimini, M. L. De, Bertagna, F., Sullo, P., Lupo, M., Cappagli, M., Fukuda, H. Hiroshi, Kunimasa, T., Furuhashi, T., Moroi, M., Yasuhi, W. Watanabe, Akihiro, S., Akio, Y., Ryou, K., Kimio, T., Yasunori, W., Yasuhiko, T., Nariaki, E., Watabe, H. Hiroshi, Teramoto, N., Ohta, Y., Kou, Y., Hayashi, T., Iida, H., Bom, H. S. Hee-Seung, Song, H. C., Min, J. J., Heo, Y. J., Seo, J. H., Lee, J. Jae-Tae, Bae, J. H., Jeong, S. Y., Ahn, B. C., Chae, S. C., Lee, K. B., Popiel, M. Malgorzata, Grajek, S., Czepczynski, R., Breborowicz, P., Lesiak, M., Czyz, A., Sawinski, K., Komarnicki, M., Cieslinski, A., Sowinski, J., Ferreira, A. António, Ventosa, A., Gil, V., Calqueiro, J., Lima, S., Aguiar, C., Couto, R., Raposo, L., Seabra-Gomes, R., Vasconcelos, M. Mariana, Martins, E., Faria, T., Oliveira, A., Garcia, M., Pereira, J., Rocha-Gonçalves, F., Lourenço, C. Cândida, Roque, C., Ferrer-Antunes, A., Ferreira, M., Providência, L. A., Lima, J., Medrea, C. Claudia, Bogdan, R., Lazar, A., Mot, S., Capilneanu, R., Kozulin, V. Vickenty, Berkovich, O., Ivashchenko, T., Larionova, V., Esipovich, I., Gordeev, M., Panov, A., Shlyakhto, E., Burova, N., Baranov, D., Timoshin, V., Chuprova, S., Shkolnikova, M., Zaklyazminskaya, E., Poliakov, A., Sazonova, S. Svetlana, Romero-Farina, G., Arenillas, J. F., Candell-Riera, J., Aguadè-Bruix, S. Santiago, Leon, G. De, Molina, C. A., Chacon, P., Montaner, J., Rovira, A., Alvarez-Sabin, J., Namdar, M. Mehdi, Siegrist, P. T., Grathwohl, R., Delaloye, R., Koepfli, P., Wyss, C. A., Kaufmann, P. A., Bartenstein, N., Hellermann, J., Siegrist, P. T. Patrick, Namdar, M., Pollack, C., Schurr, U., Kaufmann, P. A., Zellweger, M. J. Michael, Burger, P. C., Mueller-Brand, J., Pfisterer, M. E., Gordon, L. Leonie, Epps, A., Chiarameda, S., Navare, S. Sachin, Ahlberg, A., Cyr, G., Katten, D., Ausef, A., Heller, G., Darrow, B. Bruce, Thomas, G. S. Gregory, Ip, T. K., Thompson, R. C., Kramer, D. B., Rice, D. L., Thomas, J. J., Miyamoto, M. I., Druz, R. S. Regina, Nichols, K. J., Akinboboye, O. O., Reichek, N., Podrasky, E. Ernest, Tuttle, R. T. Robert, Shaw, L. S. Linda, Hanson, M. W. H. Michael, Borges-Neto, S. Salvador, Lundbye, J. Justin, Werden, S., Kazi, F., Whalen, A., Noble, G. L., O’Sullivan, D., Boden, W. E., Heller, G. V., Ausef, A. Amir, Ahlberg, A. W., Danias, P. G., Papaioannou, G. I., Leka, I. A., Boden, W. E., Heller, G. V., Beretta, M. Mario, Viňas, S., Gonzalez, A., Vidal, I., and Rener, A.
- Published
- 2005
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7. Poster session Thursday 12 December - PM: 12/12/2013, 14: 00–18: 00Location: Poster area
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Saraste, A, Luotolahti, M, Varis, A, Vasankari, T, Tunturi, S, Taittonen, M, Rautakorpi, P, Airaksinen, J, Ukkonen, H, and Knuuti, J
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- 2013
8. Low radiation dose imaging of myocardial perfusion and coronary angiography with a hybrid PET/CT scanner
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Kajander, S., Ukkonen, H., Sipilä, H., Teräs, M., and Knuuti, J.
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- 2009
9. Biochemical changes in irradiated oral mucosa:a FTIR spectroscopic study
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Ukkonen, H. (Helena), Vuokila, S. (Simo), Mikkonen, J. J. (Jopi J. W.), Dekker, H. (Hannah), Schulten, E. A. (Engelbert A. J. M.), Bloemena, E. (Elisabeth), Koistinen, A. (Arto), Valdez, T. A. (Tulio A.), Kullaa, A. M. (Arja M.), Singh, S. P. (Surya Pratap), Ukkonen, H. (Helena), Vuokila, S. (Simo), Mikkonen, J. J. (Jopi J. W.), Dekker, H. (Hannah), Schulten, E. A. (Engelbert A. J. M.), Bloemena, E. (Elisabeth), Koistinen, A. (Arto), Valdez, T. A. (Tulio A.), Kullaa, A. M. (Arja M.), and Singh, S. P. (Surya Pratap)
- Abstract
Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical maps generated using glycoprotein band indicates its differential distribution along the superficial layer. Spectra extracted from this layer suggests changes in overall nucleic acid and protein content in response to the therapeutic irradiation. Discrimination among control and irradiated groups have been achieved using principal component analysis. Findings of this preliminary study further support prospective utilization of Fourier Transform InfraRed (FTIR) imaging as a non-destructive, label-free tool for objective assessment of the oral mucosa in patient groups with or without radiation therapy.
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- 2019
10. Posters display III clinical outcome and PET
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Baliño, N., Masoli, O., Traverso, S., Grynberg, L., Rappallo, C., Redruello, M., Rosa, D., Cragnolino, D., Meretta, A., Vidal, L., Graf, S., Khorsand, A., Gyongyosi, M., Karanikas, G., Eidherr, H., Kletter, K., Porenta, G., Glogar, D., Sochor, H., Beheshti, M., Poetzi, C., Wadsak, W., Maurer, G., Wolfram, J., Winter, O., Velghe, A., Veire, N., Bondt, P., Buyzere, M., Wiele, C., Backer, G., Gillebert, T., Dierckx, R., Sutter, J., Bernard, D., Langlois, M., Duarte, P., Mastrocolla, L., Sampaio, C., Rossi, J., Smanio, P., Lima, E., Oliveira, C., Pereira, J., Beraldo, P., Rodrigues, F., Thom, A., Yoshinaga, K., Ukkonen, H., Burwash, I., DeKemp, R., Dafoe, W., Davies, R., Haddad, H., Ruddy, T., DaSilva, J., Beanlands, R., Chow, B., Williams, K., Garrard, L., Szeto, A., Aung, M., Sondergaard, H., Bottcher, M., Madsen, M., Schmitz, O., Nielsen, T., Botker, H., Høilund-Carlsen, P., Johansen, A., Christensen, H., Vach, W., Møldrup, M., Haghfelt, T., Kristensen, J., Maeng, M., Mortensen, U., Berg, J., Rehling, M., Elsaban, K., El-Kady, T., El-Gabaly, M., Yehia, A., El-Sayed, M., Naum, A., Laaksonen, M., Tuunanen, H., Oikonen, V., Kemppainen, J., Järvisalo, M., Nuutila, P., Knuuti, J., Vanzetto, G., Jacon, P., Fagret, D., Machecourt, J., Lindner, O., Vogt, J., Kammeier, A., Fricke, E., Wielepp, P., Baller, D., Lamp, B., Holzinger, J., Horstkotte, D., Burchert, W., Nekolla, S., Souvatzoglou, M., Hausleiter, J., Henke, N., Kruschke, K., Bengel, F., Schwaiger, M., Sundaram, P., Padma, S., Haridas, K., Kumar, S., Zachariah, M., Livschitz, S., Zornitzki, T., Vered, S., Oettinger, M., Levy, R., Caspi, A., Faraggi, D., Knobler, H., Mats, I., Solodky, A., Ben-Gal, T., Battler, A., Zafrir, N., Varani, E., Balducelli, M., Severi, S., Patroncini, A., Vecchi, G., Gatti, C., Corbelli, C., Casanova, R., Maresta, A., Cittanti, C., Valgimigli, M., Giganti, M., Malagutti, P., Percoco, G., Bagatin, E., Panareo, S., Avigni, N., Ferrari, R., Feggi, L., Filardi, P., Cuocolo, A., Storto, G., Brevetti, G., Dellegrottaglie, S., Corrado, L., Cafiero, M., Polimeno, M., Zarrilli, A., Chiariello, M., Marcassa, C., Campini, R., Calza, P., Giannuzzi, P., Galassi, A., Grasso, C., Azzarelli, S., Leotta, E., Moshiri, S., Tamburino, C., Acampa, W., Ferro, A., Petretta, M., Salvatore, M., Pieri, P., Berta, R., Moscatelli, G., Buccoliero, F., Inglese, E., Medolago, G., Imperiale, A., Rimini, M., Bertagna, F., Sullo, P., Lupo, M., Cappagli, M., Fukuda, H., Kunimasa, T., Furuhashi, T., Moroi, M., Yasuhi, W., Akihiro, S., Akio, Y., Ryou, K., Kimio, T., Yasunori, W., Yasuhiko, T., Nariaki, E., Watabe, H., Teramoto, N., Ohta, Y., Kou, Y., Hayashi, T., Iida, H., Bom, H., Song, H., Min, J., Heo, Y., Seo, J., Lee, J., Bae, J., Jeong, S., Ahn, B., Chae, S., Lee, K., Popiel, M., Grajek, S., Czepczynski, R., Breborowicz, P., Lesiak, M., Czyz, A., Sawinski, K., Komarnicki, M., Cieslinski, A., Sowinski, J., Ferreira, A., Ventosa, A., Gil, V., Calqueiro, J., Lima, S., Aguiar, C., Couto, R., Raposo, L., Seabra-Gomes, R., Vasconcelos, M., Martins, E., Faria, T., Oliveira, A., Garcia, M., Rocha-Gonçalves, F., Lourenço, C., Roque, C., Ferrer-Antunes, A., Ferreira, M., Providência, L., Lima, J., Medrea, C., Bogdan, R., Lazar, A., Mot, S., Capilneanu, R., Kozulin, V., Berkovich, O., Ivashchenko, T., Larionova, V., Esipovich, I., Gordeev, M., Panov, A., Shlyakhto, E., Burova, N., Baranov, D., Timoshin, V., Chuprova, S., Shkolnikova, M., Zaklyazminskaya, E., Poliakov, A., Sazonova, S., Romero-Farina, G., Arenillas, J., Candell-Riera, J., Aguadè-Bruix, S., Leon, G., Molina, C., Chacon, P., Montaner, J., Rovira, A., Alvarez-Sabin, J., Namdar, M., Siegrist, P., Grathwohl, R., Delaloye, R., Koepfli, P., Wyss, C., Kaufmann, P., Bartenstein, N., Hellermann, J., Pollack, C., Schurr, U., Zellweger, M., Burger, P., Mueller-Brand, J., Pfisterer, M., Gordon, L., Epps, A., Chiarameda, S., Navare, S., Ahlberg, A., Cyr, G., Katten, D., Ausef, A., Heller, G., Darrow, B., Thomas, G., Ip, T., Thompson, R., Kramer, D., Rice, D., Thomas, J., Miyamoto, M., Druz, R., Nichols, K., Akinboboye, O., Reichek, N., Podrasky, E., Tuttle, R., Shaw, L., Hanson, M., Borges-Neto, S., Lundbye, J., Werden, S., Kazi, F., Whalen, A., Noble, G., O'Sullivan, D., Boden, W., Danias, P., Papaioannou, G., Leka, I., Beretta, M., Viňas, S., Gonzalez, A., Vidal, I., and Rener, A.
- Published
- 2018
11. P606High intermodality variability in ejection fraction measured by echocardiography, cardiac magnetic resonance and single photon emission computed tomography in chronic coronary artery disease patients
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Stokke, T M, primary, Sarvari, S I, additional, Bjerring, A W, additional, Haugaa, K H, additional, Elahi, M T, additional, Hoedemakers, S I, additional, Rademakers, F, additional, Monaghan, M, additional, Sicari, R, additional, Engvall, J, additional, Nagel, E, additional, Zamorano, J L, additional, Ukkonen, H, additional, D'hooge, J, additional, and Edvardsen, T, additional
- Published
- 2019
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12. 361Association of quantitative myocardial perfusion characteristics and coronary atherosclerosis in patients with normal myocardial blood flow
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Maaniitty, T, primary, Stenstrom, I, additional, Harjulahti, E, additional, Maki, M, additional, Kajander, S, additional, Ukkonen, H, additional, Saraste, A, additional, and Knuuti, J, additional
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- 2019
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13. P5668Heart failure in Finland - evaluating the burden of disease and treatment patterns
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Huusko, J, primary, Kurki, S, additional, Toppila, I, additional, Purmonen, T, additional, Lassenius, M, additional, Gullberg, E, additional, Bruce Wirta, S, additional, and Ukkonen, H, additional
- Published
- 2018
- Full Text
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14. 4149Coronary CT angiography with selective PET perfusion imaging guides referral for invasive coronary angiography and revascularization in coronary artery disease
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Stenstrom, I., primary, Maaniitty, T., additional, Uusitalo, V., additional, Ukkonen, H., additional, Kajander, S., additional, Maki, M., additional, Bax, J.J., additional, Knuuti, J., additional, and Saraste, A., additional
- Published
- 2017
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15. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)
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Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Gatzoulis MA, Gohlke Baerwolf C, Kaemmerer H, Kilner P, Meijboom F, Mulder BJ, Oechslin E, Oliver JM, Serraf A, Szatmari A, Thaulow E, Vouhe PR, Walma E, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck Brentano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P, Swan L, Andreotti F, Beghetti M, Borggrefe M, Bozio A, Brecker S, Budts W, Hess J, Hirsch R, Jondeau G, Kokkonen J, Kozelj M, Kucukoglu S, Laan M, Lionis C, Metreveli I, Moons P, Pieper PG, Pilossoff V, Popelova J, Price S, Roos Hesselink J, Uva MS, Tornos P, Trindade PT, Ukkonen H, Walker H, Webb GD, Westby J, Task Force on the Management of Grown up Congenital Heart Disease of the European Society of Cardiology, GALIE', NAZZARENO, Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Galie N, Gatzoulis MA, Gohlke-Baerwolf C, Kaemmerer H, Kilner P, Meijboom F, Mulder BJ, Oechslin E, Oliver JM, Serraf A, Szatmari A, Thaulow E, Vouhe PR, Walma E, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck-Brentano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P, Swan L, Andreotti F, Beghetti M, Borggrefe M, Bozio A, Brecker S, Budts W, Hess J, Hirsch R, Jondeau G, Kokkonen J, Kozelj M, Kucukoglu S, Laan M, Lionis C, Metreveli I, Moons P, Pieper PG, Pilossoff V, Popelova J, Price S, Roos-Hesselink J, Uva MS, Tornos P, Trindade PT, Ukkonen H, Walker H, Webb GD, Westby J, and Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC)
- Subjects
CONGENITAL HEART DISEASE ,GUIDELINES ,management - Abstract
not available
- Published
- 2010
16. Characterization of coronary microvascular dysfunction in patients with suspected coronary artery disease
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Soukka, I., Maaniitty, T., Saraste, A., Pikkarainen, E., Uusitalo, V., Ukkonen, H., Kajander, S., Maki, M., Bax, J.J., and Knuuti, J.
- Published
- 2014
17. Long-Term Follow-Up of Outcomes With F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging–Assisted Management of Patients With Severe Left Ventricular Dysfunction Secondary to Coronary Disease
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Mc Ardle, Brian, primary, Shukla, Tushar, additional, Nichol, Graham, additional, deKemp, Robert A., additional, Bernick, Jordan, additional, Guo, Ann, additional, Lim, Siok Ping, additional, Davies, Ross A., additional, Haddad, Haissam, additional, Duchesne, Lloyd, additional, Hendry, Paul, additional, Masters, Roy, additional, Ross, Heather, additional, Freeman, Michael, additional, Gulenchyn, Karen, additional, Racine, Normand, additional, Humen, Dennis, additional, Benard, Francois, additional, Ruddy, Terrence D., additional, Chow, Benjamin J., additional, Mielniczuk, Lisa, additional, DaSilva, Jean N., additional, Garrard, Linda, additional, Wells, George A., additional, Beanlands, Rob S.B., additional, Higginson, L., additional, Mesana, T., additional, Ukkonen, H., additional, Yoshinaga, K., additional, Renaud, J., additional, Klein, R., additional, Aung, M., additional, Kostuk, W., additional, Wisenberg, G., additional, White, M., additional, Iwanochko, R.M., additional, Mickleborough, L., additional, Abramson, B., additional, Latter, D., additional, Lamy, A., additional, Fallen, E., additional, and Coates, G., additional
- Published
- 2016
- Full Text
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18. Young Investigator Award Competition : Sunday 3 May 2015, 08
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Bertella, E, Baggiano, A, Petulla', M, Mushtaq, S, Beltrama, V, Gripari, P, Conte, E, Russo, E, Andreini, D, Pontone, G, Soukka, I, Maaniitty, T, Saraste, A, Uusitalo, V, Ukkonen, H, Kajander, S, Maki, M, Bax, J, Knuuti, J, De Graaf, M A, Caselli, C, Lorenzoni, V, Rovai, D, Marinelli, M, Del Ry, S, Giannessi, D, Bax, J J, Scholte, A J, Neglia, D, Thackeray, J T, Korf-Klingebiel, M, Wang, Y, Kustikova, O, Bankstahl, J P, Wollert, K C, Bengel, F M, Harms, H J, Tolbod, L P, Hansson, N H, Kim, W Y, Bouchelouche, K, Wiggers, H, Frokiaer, J, Sörensen, Jens, Stenstrom, I, Bertella, E, Baggiano, A, Petulla', M, Mushtaq, S, Beltrama, V, Gripari, P, Conte, E, Russo, E, Andreini, D, Pontone, G, Soukka, I, Maaniitty, T, Saraste, A, Uusitalo, V, Ukkonen, H, Kajander, S, Maki, M, Bax, J, Knuuti, J, De Graaf, M A, Caselli, C, Lorenzoni, V, Rovai, D, Marinelli, M, Del Ry, S, Giannessi, D, Bax, J J, Scholte, A J, Neglia, D, Thackeray, J T, Korf-Klingebiel, M, Wang, Y, Kustikova, O, Bankstahl, J P, Wollert, K C, Bengel, F M, Harms, H J, Tolbod, L P, Hansson, N H, Kim, W Y, Bouchelouche, K, Wiggers, H, Frokiaer, J, Sörensen, Jens, and Stenstrom, I
- Published
- 2015
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19. Poster Session 1: Sunday 3 May 2015, 08:30-18:00 * Room: Poster Area
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Taniguchi, Y., primary, Takahashi, Y., additional, Toba, T., additional, Yamada, S., additional, Yokoi, K., additional, Kobayashi, S., additional, Okajima, S., additional, Shimane, A., additional, Kawai, H., additional, Yasaka, Y., additional, Smanio, P., additional, Oliveira, M. A., additional, Machado, L., additional, Cestari, P., additional, Medeiros, E., additional, Fukuzawa, S., additional, Okino, S., additional, Ikeda, A., additional, Maekawa, J., additional, Ichikawa, S., additional, Kuroiwa, N., additional, Yamanaka, K., additional, Igarashi, A., additional, Inagaki, M., additional, Patel, K., additional, Mahan, M., additional, Ananthasubramaniam, K., additional, Mouden, M., additional, Yokota, S., additional, Ottervanger, J., additional, Knollema, S., additional, Timmer, J., additional, Jager, P., additional, Padron, K., additional, Peix, A., additional, Cabrera, L., additional, Pena Bofill, V., additional, Valera, D., additional, Rodriguez Nande, L., additional, Carrillo Hernandez, R., additional, Mena Esnard, E., additional, Fernandez Columbie, Y., additional, Bertella, E., additional, Baggiano, A., additional, Mushtaq, S., additional, Segurini, C., additional, Loguercio, M., additional, Conte, E., additional, Beltrama, V., additional, Petulla', M., additional, Andreini, D., additional, Pontone, G., additional, Guzic Salobir, B., additional, Dolenc Novak, M., additional, Jug, B., additional, Kacjan, B., additional, Novak, Z., additional, Vrtovec, M., additional, Volpato, V., additional, Formenti, A., additional, Pepi, M., additional, Ajanovic, R., additional, Husic-Selimovic, A., additional, Zujovic-Ajanovic, A., additional, Mlynarski, R., additional, Mlynarska, A., additional, Golba, K., additional, Sosnowski, M., additional, Ameta, D., additional, Goyal, M., additional, Kumar, D., additional, Chandra, S., additional, Sethi, R., additional, Puri, A., additional, Dwivedi, S. K., additional, Narain, V. S., additional, Saran, R. K., additional, Nekolla, S., additional, Rischpler, C., additional, Nicolosi, S., additional, Langwieser, N., additional, Dirschinger, R., additional, Laugwitz, K., additional, Schwaiger, M., additional, Goral, J. L., additional, Napoli, J., additional, Forcada, P., additional, Zucchiatti, N., additional, Damico, A., additional, Olivieri, D., additional, Lavorato, M., additional, Dubesarsky, E., additional, Montana, O., additional, Salgado, C., additional, Jimenez-Heffernan, A., additional, Ramos-Font, C., additional, Lopez-Martin, J., additional, Sanchez De Mora, E., additional, Lopez-Aguilar, R., additional, Manovel, A., additional, Martinez, A., additional, Rivera, F., additional, Soriano, E., additional, Maroz-Vadalazhskaya, N., additional, Trisvetova, E., additional, Vrublevskaya, O., additional, Abazid, R., additional, Kattea, M., additional, Saqqah, H., additional, Sayed, S., additional, Smettei, O., additional, Winther, S., additional, Svensson, M., additional, Birn, H., additional, Jorgensen, H., additional, Botker, H., additional, Ivarsen, P., additional, Bottcher, M., additional, Maaniitty, T., additional, Stenstrom, I., additional, Saraste, A., additional, Pikkarainen, E., additional, Uusitalo, V., additional, Ukkonen, H., additional, Kajander, S., additional, Bax, J., additional, Knuuti, J., additional, Choi, T., additional, Park, H., additional, Lee, C., additional, Lee, J., additional, Seo, Y., additional, Cho, Y., additional, Hwang, E., additional, Cho, D., additional, Sanchez Enrique, C., additional, Ferrera, C., additional, Olmos, C., additional, Jimenez - Ballve, A., additional, Perez - Castejon, M. J., additional, Fernandez, C., additional, Vivas, D., additional, Vilacosta, I., additional, Nagamachi, S., additional, Onizuka, H., additional, Nishii, R., additional, Mizutani, Y., additional, Kitamura, K., additional, Lo Presti, M., additional, Polizzi, V., additional, Pino, P., additional, Luzi, G., additional, Bellavia, D., additional, Fiorilli, R., additional, Madeo, A., additional, Malouf, J., additional, Buffa, V., additional, Musumeci, F., additional, Rosales, S., additional, Puente, A., additional, Zafrir, N., additional, Shochat, T., additional, Mats, A., additional, Solodky, A., additional, Kornowski, R., additional, Lorber, A., additional, Boemio, A., additional, Pellegrino, T., additional, Paolillo, S., additional, Piscopo, V., additional, Carotenuto, R., additional, Russo, B., additional, Pellegrino, S., additional, De Matteis, G., additional, Perrone-Filardi, P., additional, Cuocolo, A., additional, Petretta, M., additional, Amirov, N., additional, Ibatullin, M., additional, Sadykov A, A., additional, Saifullina, G., additional, Ruano, R., additional, Diego Dominguez, M., additional, Rodriguez Gabella, T., additional, Diego Nieto, A., additional, Diaz Gonzalez, L., additional, Garcia-Talavera, J., additional, Sanchez Fernandez, P., additional, Leen, A., additional, Al Younis, I., additional, Zandbergen-Harlaar, S., additional, Verberne, H., additional, Gimelli, A., additional, Veltman, C., additional, Wolterbeek, R., additional, Scholte, A., additional, Mooney, D., additional, Rosenblatt, J., additional, Dunn, T., additional, Vasaiwala, S., additional, Okuda, K., additional, Nakajima, K., additional, Nystrom, K., additional, Edenbrandt, L., additional, Matsuo, S., additional, Wakabayashi, H., additional, Hashimoto, M., additional, Kinuya, S., additional, Iric-Cupic, V., additional, Milanov, S., additional, Davidovic, G., additional, Zdravkovic, V., additional, Ashikaga, K., additional, Yoneyama, K., additional, Akashi, Y., additional, Shugushev, Z., additional, Maximkin, D., additional, Chepurnoy, A., additional, Volkova, O., additional, Baranovich, V., additional, Faibushevich, A., additional, El Tahlawi, M., additional, Elmurr, A., additional, Alzubaidi, S., additional, Sakrana, A., additional, Gouda, M., additional, El Tahlawi, R., additional, Sellem, A., additional, Melki, S., additional, Elajmi, W., additional, Hammami, H., additional, Okano, M., additional, Kato, T., additional, Kimura, M., additional, Funasako, M., additional, Nakane, E., additional, Miyamoto, S., additional, Izumi, T., additional, Haruna, T., additional, Inoko, M., additional, Massardo, T., additional, Swett, E., additional, Fernandez, R., additional, Vera, V., additional, Zhindon, J., additional, Alay, R., additional, Ohshima, S., additional, Nishio, M., additional, Kojima, A., additional, Tamai, S., additional, Kobayashi, T., additional, Murohara, T., additional, Burrell, S., additional, Van Rosendael, A., additional, Van Den Hoogen, I., additional, De Graaf, M., additional, Roelofs, J., additional, Kroft, L., additional, Rjabceva, I., additional, Krumina, G., additional, Kalvelis, A., additional, Chanakhchyan, F., additional, Vakhromeeva, M., additional, Kankiya, E., additional, Koppes, J., additional, Knol, R., additional, Wondergem, M., additional, Van Der Ploeg, T., additional, Van Der Zant, F., additional, Lazarenko, S. V., additional, Bruin, V. S., additional, Pan, X. B., additional, Declerck, J. M., additional, Van Der Zant, F. M., additional, Knol, R. J. J., additional, Juarez-Orozco, L. E., additional, Alexanderson, E., additional, Slart, R., additional, Tio, R., additional, Dierckx, R., additional, Zeebregts, C., additional, Boersma, H., additional, Hillege, H., additional, Martinez-Aguilar, M., additional, Jordan-Rios, A., additional, Christensen, T. E., additional, Ahtarovski, K. A., additional, Bang, L. E., additional, Holmvang, L., additional, Soeholm, H., additional, Ghotbi, A. A., additional, Andersson, H., additional, Ihlemann, N., additional, Kjaer, A., additional, Hasbak, P., additional, Gulya, M., additional, Lishmanov, Y. B., additional, Zavadovskii, K., additional, Lebedev, D., additional, Stahle, M., additional, Hellberg, S., additional, Liljenback, H., additional, Virta, J., additional, Metsala, O., additional, Yla-Herttuala, S., additional, Saukko, P., additional, Roivainen, A., additional, Thackeray, J., additional, Wang, Y., additional, Bankstahl, J., additional, Wollert, K., additional, Bengel, F., additional, Saushkina, Y., additional, Evtushenko, V., additional, Minin, S., additional, Efimova, I., additional, Evtushenko, A., additional, Smishlyaev, K., additional, Lishmanov, Y., additional, Maslov, L., additional, Kirihara, Y., additional, Sugino, S., additional, Taki, J., additional, Ahmadian, A., additional, Berman, J., additional, Govender, P., additional, Ruberg, F., additional, Miller, E., additional, Piriou, N., additional, Pallardy, A., additional, Valette, F., additional, Cahouch, Z., additional, Mathieu, C., additional, Warin-Fresse, K., additional, Gueffet, J., additional, Serfaty, J., additional, Trochu, J., additional, Kraeber-Bodere, F., additional, Van Dijk, J., additional, Van Dalen, J., additional, Ofrk, H., additional, Vaturi, M., additional, Hassid, Y., additional, Belzer, D., additional, Sagie, A., additional, Kaminek, M., additional, Metelkova, I., additional, Budikova, M., additional, Koranda, P., additional, Henzlova, L., additional, Sovova, E., additional, Kincl, V., additional, Drozdova, A., additional, Jordan, M., additional, Shahid, F., additional, Teoh, Y., additional, Thamen, R., additional, Hara, N., additional, Onoguchi, M., additional, Hojyo, O., additional, Kawaguchi, Y., additional, Murai, M., additional, Udaka, F., additional, Matsuzawa, Y., additional, Bulugahapitiya, D. S., additional, Avison, M., additional, Martin, J., additional, Liu, Y.-H., additional, Wu, J., additional, Liu, C., additional, Sinusas, A., additional, Daou, D., additional, Sabbah, R., additional, Bouladhour, H., additional, Coaguila, C., additional, Aguade-Bruix, S., additional, Pizzi, M., additional, Romero-Farina, G., additional, Candell-Riera, J., additional, Castell-Conesa, J., additional, Patchett, N., additional, Sverdlov, A., additional, Boulaamayl El Fatemi, S., additional, Sallam, L., additional, Snipelisky, D., additional, Park, J., additional, Ray, J., additional, Shapiro, B., additional, Kostkiewicz, M., additional, Szot, W., additional, Holcman, K., additional, Lesniak-Sobelga, A., additional, Podolec, P., additional, Clerc, O., additional, Possner, M., additional, Liga, R., additional, Vontobel, J., additional, Mikulicic, F., additional, Graeni, C., additional, Benz, D., additional, Herzog, B., additional, Gaemperli, O., additional, and Kaufmann, P., additional
- Published
- 2015
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20. Moderated Poster Session 5: Tuesday 5 May 2015, 10:00-11:00 * Room: Moderated Poster Area
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Nudi, F., primary, Procaccini, E., additional, Neri, G., additional, Vetere, M., additional, Biondi-Zoccai, G., additional, Tomai, F., additional, Solomyanyy, V., additional, Al-Housni, M. B., additional, Hinton-Taylor, S., additional, Ilsley, C., additional, Kelion, A., additional, Palyo, R., additional, Sinusas, A., additional, Liu, Y.-H., additional, Ruano, R., additional, Diego Dominguez, M., additional, Diego Nieto, A., additional, Diaz Gonzalez, L., additional, Garcia Piney, E., additional, Sanchez Fernandez, P., additional, Garcia-Talavera, J., additional, Soukka, I., additional, Maaniitty, T., additional, Saraste, A., additional, Pikkarainen, E., additional, Uusitalo, V., additional, Ukkonen, H., additional, Kajander, S., additional, Maki, M., additional, Bax, J., additional, Knuuti, J., additional, Caobelli, F., additional, Akin, M., additional, Brunkhorst, T., additional, Thackeray, J., additional, Widder, J., additional, Berding, G., additional, Bauersachs, J., additional, Bengel, F., additional, Shrestha, U., additional, Seo, Y., additional, Botvinick, E., additional, and Gullberg, G., additional
- Published
- 2015
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21. Young Investigator Award Competition: Sunday 3 May 2015, 08:30-10:00 * Room: Milan
- Author
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Bertella, E., primary, Baggiano, A., additional, Petulla', M., additional, Mushtaq, S., additional, Beltrama, V., additional, Gripari, P., additional, Conte, E., additional, Russo, E., additional, Andreini, D., additional, Pontone, G., additional, Soukka, I., additional, Maaniitty, T., additional, Saraste, A., additional, Uusitalo, V., additional, Ukkonen, H., additional, Kajander, S., additional, Maki, M., additional, Bax, J., additional, Knuuti, J., additional, De Graaf, M. A., additional, Caselli, C., additional, Lorenzoni, V., additional, Rovai, D., additional, Marinelli, M., additional, Del Ry, S., additional, Giannessi, D., additional, Scholte, A., additional, Neglia, D., additional, Thackeray, J., additional, Korf-Klingebiel, M., additional, Wang, Y., additional, Kustikova, O., additional, Bankstahl, J., additional, Wollert, K., additional, Bengel, F., additional, Harms, H., additional, Tolbod, L., additional, Hansson, N., additional, Kim, W., additional, Bouchelouche, K., additional, Wiggers, H., additional, Frokiaer, J., additional, Sorensen, J., additional, and Stenstrom, I., additional
- Published
- 2015
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22. Effect of spinal cord stimulation on myocardial perfusion reserve in patients with refractory angina pectoris
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Saraste, A., primary, Ukkonen, H., additional, Varis, A., additional, Vasankari, T., additional, Tunturi, S., additional, Taittonen, M., additional, Rautakorpi, P., additional, Luotolahti, M., additional, Airaksinen, K. E. J., additional, and Knuuti, J., additional
- Published
- 2014
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23. Absolute flow or myocardial flow reserve for the detection of significant coronary artery disease?
- Author
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Joutsiniemi, E., primary, Saraste, A., additional, Pietila, M., additional, Maki, M., additional, Kajander, S., additional, Ukkonen, H., additional, Airaksinen, J., additional, and Knuuti, J., additional
- Published
- 2014
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24. Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy
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Tuunanen, H., Engblom, E., Naum, A., Nagren, K., Scheinin, M., Hesse, B., Airaksinen, K.E. Juhani, Nuutila, P., Iozzo, P., Ukkonen, H., Opie, L.H., Knuuti, J., Tuunanen, H., Engblom, E., Naum, A., Nagren, K., Scheinin, M., Hesse, B., Airaksinen, K.E. Juhani, Nuutila, P., Iozzo, P., Ukkonen, H., Opie, L.H., and Knuuti, J.
- Abstract
BACKGROUND: The anti-ischemic agent trimetazidine improves ejection fraction in heart failure that is hypothetically linked to inhibitory effects on cardiac free fatty acid (FFA) oxidation. However, FFA oxidation remains unmeasured in humans. We investigated the effects of trimetazidine on cardiac perfusion, efficiency of work, and FFA oxidation in idiopathic dilated cardiomyopathy. METHODS AND RESULTS: Nineteen nondiabetic patients with idiopathic dilated cardiomyopathy on standard medication were randomized to single-blind trimetazidine (n=12) or placebo (n=7) for 3 months. Myocardial perfusion, FFA, and total oxidative metabolism were measured using positron emission tomography with [(15)O]H(2)O, [(11)C]acetate, and [(11)C]palmitate. Cardiac function was assessed echocardiographically; insulin sensitivity was assessed by the homeostasis model assessment index. Trimetazidine increased ejection fraction from 30.9+/-8.5% to 34.8+/-12% (P=0.027 versus placebo). Myocardial FFA uptake was unchanged, and beta-oxidation rate constant decreased only 10%. Myocardial perfusion, oxidative metabolism, and work efficiency remained unchanged. Trimetazidine decreased insulin resistance (glucose: 5.9+/-0.7 versus 5.5+/-0.6 mmol/L, P=0.047; insulin: 10+/-6.9 versus 7.6+/-3.6 mU/L, P=0.031; homeostasis model assessment index: 2.75+/-2.28 versus 1.89+/-1.06, P=0.027). The degree of beta-blockade and trimetazidine interacted positively on ejection fraction. Plasma high-density lipoprotein concentrations increased 11% (P<0.001). CONCLUSIONS: In idiopathic dilated cardiomyopathy with heart failure, trimetazidine increased cardiac function and had both cardiac and extracardiac metabolic effects. Cardiac FFA oxidation modestly decreased and myocardial oxidative rate was unchanged, implying increased oxidation of glucose. Trimetazidine improved whole-body insulin sensitivity and glucose control in these insulin-resistant idiopathic dilated cardiomyopathy patients, thus hypothetically c
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- 2008
25. Resting coronary flow velocity in the functional evaluation of coronary artery stenosis: study on sequential use of computed tomography angiography and transthoracic Doppler echocardiography
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Joutsiniemi, E., primary, Saraste, A., additional, Pietila, M., additional, Ukkonen, H., additional, Kajander, S., additional, Maki, M., additional, Koskenvuo, J., additional, Airaksinen, J., additional, Hartiala, J., additional, Saraste, M., additional, and Knuuti, J., additional
- Published
- 2011
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26. Abstracts
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Dunet, V., primary, Dabiri, A., additional, Allenbach, G., additional, Goyeneche Achigar, A., additional, Waeber, B., additional, Feihl, F., additional, Heinzer, R., additional, Prior, J. O., additional, Van Velzen, J. E., additional, Schuijf, J. D., additional, De Graaf, F. R., additional, De Graaf, M. A., additional, Schalij, M. J., additional, Kroft, L. J., additional, De Roos, A., additional, Jukema, J. W., additional, Van Der Wall, E. E., additional, Bax, J. J., additional, Lankinen, E., additional, Saraste, A., additional, Noponen, T., additional, Klen, R., additional, Teras, M., additional, Kokki, T., additional, Kajander, S., additional, Pietila, M., additional, Ukkonen, H., additional, Knuuti, J., additional, Pazhenkottil, A. P., additional, Nkoulou, R. N., additional, Ghadri, J. R., additional, Herzog, B. A., additional, Buechel, R. R., additional, Kuest, S. M., additional, Wolfrum, M., additional, Gaemperli, O., additional, Husmann, L., additional, Kaufmann, P. A., additional, Andreini, D., additional, Pontone, G., additional, Mushtaq, S., additional, Antonioli, L., additional, Bertella, E., additional, Formenti, A., additional, Cortinovis, S., additional, Ballerini, G., additional, Fiorentini, C., additional, Pepi, M., additional, Koh, A. S., additional, Flores, J. S., additional, Keng, F. Y. J., additional, Tan, R. S., additional, Chua, T. S. J., additional, Annoni, A. D., additional, Tamborini, G., additional, Fusari, M., additional, Bartorelli, A. L., additional, Ewe, S. H., additional, Ng, A. C. T., additional, Delgado, V., additional, Schuijf, J., additional, Van Der Kley, F., additional, Colli, A., additional, De Weger, A., additional, Marsan, N. A., additional, Yiu, K. H., additional, Ng, A. C., additional, Timmer, S. A. J., additional, Knaapen, P., additional, Germans, T., additional, Dijkmans, P. A., additional, Lubberink, M., additional, Ten Berg, J. M., additional, Ten Cate, F. J., additional, Russel, I. K., additional, Lammertsma, A. A., additional, Van Rossum, A. C., additional, Wong, Y. Y., additional, Ruiter, G., additional, Raijmakers, P., additional, Van Der Laarse, W. J., additional, Westerhof, N., additional, Vonk-Noordegraaf, A., additional, Youssef, G., additional, Leung, E., additional, Wisenberg, G., additional, Marriot, C., additional, Williams, K., additional, Etele, J., additional, Dekemp, R. A., additional, Dasilva, J., additional, Birnie, D., additional, Beanlands, R. S. B., additional, Thompson, R. C., additional, Allam, A. H., additional, Wann, L. S., additional, Nureldin, A. H., additional, Adelmaksoub, G., additional, Badr, I., additional, Sutherland, M. L., additional, Sutherland, J. D., additional, Miyamoto, M. I., additional, Thomas, G. S., additional, Harms, H. J., additional, De Haan, S., additional, Huisman, M. C., additional, Schuit, R. C., additional, Windhorst, A. D., additional, Allaart, C., additional, Einstein, A. J., additional, Khawaja, T., additional, Greer, C., additional, Chokshi, A., additional, Jones, M., additional, Schaefle, K., additional, Bhatia, K., additional, Shimbo, D., additional, Schulze, P. C., additional, Srivastava, A., additional, Chettiar, R., additional, Moody, J., additional, Weyman, C., additional, Natale, D., additional, Bruni, W., additional, Liu, Y., additional, Ficaro, E., additional, Sinusas, A. J., additional, Peix, A., additional, Batista, E., additional, Cabrera, L. O., additional, Padron, K., additional, Rodriguez, L., additional, Sainz, B., additional, Mendoza, V., additional, Carrillo, R., additional, Fernandez, Y., additional, Mena, E., additional, Naum, A., additional, Bach-Gansmo, T., additional, Kleven-Madsen, N., additional, Biermann, M., additional, Johnsen, B., additional, Aase Husby, J., additional, Rotevatn, S., additional, Nordrehaug, J. E., additional, Schaap, J., additional, Kauling, R. M., additional, Post, M. C., additional, Rensing, B. J. W. M., additional, Verzijlbergen, J. F., additional, Sanchez, J., additional, Giamouzis, G., additional, Tziolas, N., additional, Georgoulias, P., additional, Karayannis, G., additional, Chamaidi, A., additional, Zavos, N., additional, Koutrakis, K., additional, Sitafidis, G., additional, Skoularigis, J., additional, Triposkiadis, F., additional, Radovanovic, S., additional, Djokovic, A., additional, Simic, D. V., additional, Krotin, M., additional, Savic-Radojevic, A., additional, Pljesa-Ercegovac, M., additional, Zdravkovic, M., additional, Saponjski, J., additional, Jelic, S., additional, Simic, T., additional, Eckardt, R., additional, Kjeldsen, B. J., additional, Andersen, L. I., additional, Haghfelt, T., additional, Grupe, P., additional, Johansen, A., additional, Hesse, B., additional, Pena, H., additional, Cantinho, G., additional, Wilk, M., additional, Srour, Y., additional, Godinho, F., additional, Zafrir, N., additional, Gutstein, A., additional, Mats, I., additional, Battler, A., additional, Solodky, A., additional, Sari, E., additional, Singh, N., additional, Vara, A., additional, Peters, A. M., additional, De Belder, A., additional, Nair, S., additional, Ryan, N., additional, James, R., additional, Dizdarevic, S., additional, Depuey, G., additional, Friedman, M., additional, Wray, R., additional, Old, R., additional, Babla, H., additional, Chuanyong, B., additional, Maddahi, J., additional, Tragardh Johansson, E., additional, Sjostrand, K., additional, Edenbrandt, L., additional, Aguade-Bruix, S., additional, Cuberas-Borros, G., additional, Pizzi, M. N., additional, Sabate-Fernandez, M., additional, De Leon, G., additional, Garcia-Dorado, D., additional, Castell-Conesa, J., additional, Candell-Riera, J., additional, Casset-Senon, D., additional, Edjlali-Goujon, M., additional, Alison, D., additional, Delhommais, A., additional, Cosnay, P., additional, Low, C. S., additional, Notghi, A., additional, O'brien, J., additional, Tweddel, A. 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L., additional, Giordano, A., additional, Kapitan, M., additional, Paolino, A., additional, Nunez, M., additional, Sweeny, J., additional, Kulkarni, N., additional, Guma, K., additional, Akashi, Y., additional, Takano, M., additional, Takai, M., additional, Koh, S., additional, Miyake, F., additional, Torun, N., additional, Durmus Altun, G., additional, Altun, A., additional, Kaya, E., additional, Saglam, H., additional, Matsuoka, D. T., additional, Sanchez, A., additional, Bartolozzi, C., additional, Padua, D., additional, Ponta, G., additional, Ponte, A., additional, Carneiro, A., additional, Thom, A., additional, Ashrafi, R., additional, Garg, P., additional, Davis, G., additional, Falcao, A., additional, Costa, M., additional, Bussolini, F., additional, Meneghetti, J. A. C., additional, Tobisaka, M., additional, Correia, E., additional, Jansen, J. W., additional, Van Der Vleuten, P. A., additional, Willems, T. 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C., additional, Genovesi, D., additional, Giorgetti, A., additional, Gimelli, A., additional, Cannizzaro, G., additional, Bertagna, F., additional, Fagioli, G., additional, Rossi, M., additional, Bonini, R., additional, Marzullo, P., additional, Paterson, C. A., additional, Smith, S. A., additional, Small, A. D., additional, Goodfield, N. E. R., additional, Martin, W., additional, Nekolla, S., additional, Sherif, H., additional, Reder, S., additional, Yu, M., additional, Kusch, A., additional, Li, D., additional, Zou, J., additional, Lloyd, M. S., additional, Cao, K., additional, Motherwell, D. W., additional, Rice, A., additional, Mccurrach, G. M., additional, Cobbe, S. M., additional, Petrie, M. C., additional, Al Younis, I., additional, Van Der Wall, E., additional, Mirza, T., additional, Raza, M., additional, Hashemizadeh, H., additional, Santos, L., additional, Krishna, B. A., additional, Perna, F., additional, Lago, M., additional, Leo, M., additional, Pelargonio, G., additional, Bencardino, G., additional, Narducci, M. L., additional, Casella, M., additional, Bellocci, F., additional, Kirac, S., additional, Yaylali, O., additional, Serteser, M., additional, Yaylali, T., additional, Okizaki, A., additional, Urano, Y., additional, Nakayama, M., additional, Ishitoya, S., additional, Sato, J., additional, Ishikawa, Y., additional, Sakaguchi, M., additional, Nakagami, N., additional, Aburano, T., additional, Solav, S. V., additional, Bhandari, R., additional, Burrell, S., additional, Dorbala, S., additional, Bruno, I., additional, Caldarella, C., additional, Collarino, A., additional, Mattoli, M. V., additional, Stefanelli, A., additional, Cannarile, A., additional, Maggi, F., additional, Soukhov, V., additional, Bondarev, S., additional, Yalfimov, A., additional, Khan, M., additional, Priyadharshan, P. 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B., additional, Aksoy, T., additional, Slavich, G. A., additional, Piccoli, G., additional, Puppato, M., additional, Grillone, S., additional, Gasparini, D., additional, Dunet, V., additional, Perruchoud, S., additional, Poitry-Yamate, C., additional, Lepore, M., additional, Gruetter, R., additional, Pedrazzini, T., additional, Anselm, D., additional, Anselm, A., additional, Atkins, H., additional, Renaud, J., additional, Dekemp, R., additional, Burwash, I., additional, Guo, A., additional, Beanlands, R., additional, Glover, C., additional, Vilardi, I., additional, Zangheri, B., additional, Calabrese, L., additional, Romano, P., additional, Bruno, A., additional, Fernandez Cimadevilla, O. C., additional, Uusitalo, V. A., additional, Luotolahti, M., additional, Wendelin-Saarenhovi, M., additional, Sundell, J., additional, Raitakari, O., additional, Huidu, S., additional, Gadiraju, R., additional, Ghesani, M., additional, Uddin, Q., additional, Wosnitzer, B., additional, Takahashi, N., additional, Alhaj, E., additional, Legasto, A., additional, Abiri, B., additional, Elsaban, K., additional, El Khouly, T., additional, El Kammash, T., additional, Al Ghamdi, A., additional, Kyung Deok, B., additional, Bon Seung, K., additional, Sang Geun, Y., additional, Chang Min, D., additional, and Gwan Hong, M., additional
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- 2011
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27. Cardiac Positron Emission Tomography/Computed Tomography Imaging Accurately Detects Anatomically and Functionally Significant Coronary Artery Disease
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Kajander, S., primary, Joutsiniemi, E., additional, Saraste, M., additional, Pietilä, M., additional, Ukkonen, H., additional, Saraste, A., additional, Sipilä, H.T., additional, Teräs, M., additional, Mäki, M., additional, Airaksinen, J., additional, Hartiala, J., additional, and Knuuti, J., additional
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- 2010
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28. Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy
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Miettinen, J. A, primary, Ylitalo, K., additional, Hedberg, P., additional, Jokelainen, J., additional, Kervinen, K., additional, Niemela, M., additional, Saily, M., additional, Koistinen, P., additional, Savolainen, E.-R., additional, Ukkonen, H., additional, Pietila, M., additional, Airaksinen, K E J., additional, Knuuti, J., additional, Vuolteenaho, O., additional, Makikallio, T. H, additional, and Huikuri, H. V, additional
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- 2009
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29. Effects of CRT on myocardial innervation, perfusion and metabolism
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Ukkonen, H., primary, Sundell, J., additional, and Knuuti, J., additional
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- 2008
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30. 16.27Low Dose Cardiac CTA on a Hybrid PET-CT Scanner: Initial Experience and Comparison with Spiral MDCT
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KAJANDER, S, primary, UKKONEN, H, additional, and KNUUTI, J, additional
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- 2007
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31. Coronary artery flow velocity profile measured by transthoracic Doppler echocardiography predicts myocardial viability after acute myocardial infarction
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Saraste, A., primary, Koskenvuo, J. W, additional, Saraste, M., additional, Parkka, J., additional, Toikka, J., additional, Naum, A., additional, Ukkonen, H., additional, Knuuti, J., additional, Airaksinen, J., additional, and Hartiala, J., additional
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- 2007
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32. 11.6The effect of partial FFA betaoxidation inhibition on myocardial metabolism and function in patients with idiopathic dilated cardiomyopathy
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TUUNANEN, H, primary, ENGBLOM, E, additional, HESSE, B, additional, AIRAKSINEN, K, additional, IOZZO, P, additional, UKKONEN, H, additional, OPIE, L, additional, and KNUUTI, J, additional
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- 2007
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33. 2.5
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Tuunanen, H. Helena, primary, Engblom, E., additional, Airaksinen, K.E.J., additional, Nuutila, P., additional, Hesse, B., additional, Ukkonen, H., additional, Opie, L., additional, and Knuuti, J., additional
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- 2007
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34. 29.16The effect of acute FFA availability limitation on cardiac function and efficiency in patients with idiopathic dilated cardiomyopathy and heart failure
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UKKONEN, H, primary, TUUNANEN, H, additional, ENGBLOM, E, additional, OPIE, L, additional, AIRAKSINEN, J, additional, and KNUUTI, J, additional
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- 2006
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35. 200 Cardiac function and efficiency are dependent on FFA availability in patients with idiopathic dilated cardiomyopathy
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TUUNANEN, H, primary, ENGBLOM, E, additional, OPIE, L, additional, HESSE, B, additional, AIRAKSINEN, J, additional, NUUTILA, P, additional, UKKONEN, H, additional, and KNUUTI, J, additional
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- 2006
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36. 303 The effect of FFA betaoxidation inhibution on myocardial metabolism and function in patients with idiopathic dilated cardiomyopathy
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TUUNANEN, H, primary, ENGBLOM, E, additional, OPIE, L, additional, HESSE, B, additional, AIRAKSINEN, J, additional, IOZZO, P, additional, UKKONEN, H, additional, and KNUUTI, J, additional
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- 2006
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37. Myocardial efficiency reserve predicts the deterioration in exercise capacity over time in patients with heart failure
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YOSHINAGA, K, primary, UKKONEN, H, additional, BURWASH, I, additional, DEKEMP, R, additional, DAFOE, W, additional, DAVIES, R, additional, HADDAD, H, additional, RUDDY, T, additional, DASILVA, J, additional, and BEANLANDS, R, additional
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- 2005
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38. Myocardial efficiency during levosimendan infusion in congestive heart failure
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Ukkonen, H, primary
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- 2000
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39. Head-to-head comparison of 11C-acetate and 15O2 PET for myocardial oxygen utilization in man
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UKKONEN, H, primary
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- 1999
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40. Myocardial efficiency during levosimendan infusion
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Voipio-Pulkki, L-M and Ukkonen, H
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Meeting Abstract - Published
- 2002
41. Listeria monocytogenesArthritis of Several Joints
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Ukkonen, H. J., primary, Vuori, K. P., additional, Lehtonen, O. P., additional, and Kotilainen, P. M., additional
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- 1995
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42. Is ventilatory efficiency (VE/VCO(2) slope) associated with right ventricular oxidative metabolism in patients with congestive heart failure?
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Ukkonen H, Burwash IG, Dafoe W, de Kemp RA, Haddad H, Yoshinaga K, Davies RA, Gannon EK, Dasilva JN, Beanlands RS, Ukkonen, Heikki, Burwash, Ian G, Dafoe, William, de Kemp, Robert A, Haddad, Haissam, Yoshinaga, Keiichiro, Davies, Ross A, Gannon, Edward K, Dasilva, Jean N, and Beanlands, Rob S B
- Abstract
Background: The relationship between minute ventilation and the rate of CO2 elimination (VE/VCO2 slope) is associated with mortality in patients with congestive heart failure (CHF). The VE/VCO2 slope > or =34 denotes a poor prognosis and has been proposed to reflect abnormalities in pulmonary perfusion.Aims: To study whether increased VE/VCO2 slope is associated with elevated right ventricular (RV) oxidative metabolism relative to the left ventricle (LV).Methods: 21 patients with stable NYHA II-III CHF underwent symptom limited cardiopulmonary exercise testing. Dynamic [(11)C]acetate positron emission tomography (PET) was used to measure oxidative metabolism (k(mono)) of the LV and RV. Corrected RV oxidative metabolism (RVOx) was calculated as RV/LV k(mono) ratio.Results: Peak VO2 was 16.2+/-4.1 ml/min/kg and the VE/VCO2 slope was 33.4+/-6.1. LV and RV k(mono) were 0.046+/-0.009 and 0.037+/-0.007 min(-1), respectively, with a RVOx of 0.83+/-0.17. There was a good correlation between RVOx and the VE/VCO2 slope (r=0.61, p=0.0034). RVOx was 0.77+/-0.16 in patients with a VE/VCO2 slope <34 and 0.93+/-0.16 in patients with VE/VCO2 slope > or =34 (p=0.047).Conclusion: RVOx correlates with VE/VCO2 slope in CHF patients. This supports the hypothesis that pulmonary vascular resistance is a determinant of the VE/VCO2 slope. [ABSTRACT FROM AUTHOR]- Published
- 2008
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43. Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy.
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Tuunanen H, Engblom E, Naum A, Någren K, Scheinin M, Hesse B, Airaksinen J, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J, and LeWinter MM
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- 2008
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44. Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure.
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Tuunanen H, Engblom E, Naum A, Någren K, Hesse B, Airaksinen KE, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J, Tuunanen, Helena, Engblom, Erik, Naum, Alexandru, Någren, Kjell, Hesse, Birger, Airaksinen, K E Juhani, Nuutila, Pirjo, Iozzo, Patricia, and Ukkonen, Heikki
- Published
- 2006
45. 16.27: Low Dose Cardiac CTA on a Hybrid PET-CT Scanner: Initial Experience and Comparison with Spiral MDCT
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Kajander, S., Ukkonen, H., and Knuuti, J.
- Published
- 2007
- Full Text
- View/download PDF
46. 11.6: The effect of partial FFA betaoxidation inhibition on myocardial metabolism and function in patients with idiopathic dilated cardiomyopathy
- Author
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Tuunanen, H. Helena, Engblom, E., Hesse, B., Airaksinen, K.E.J., Iozzo, P., Ukkonen, H., Opie, L., and Knuuti, J.
- Published
- 2007
- Full Text
- View/download PDF
47. 2.5: Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure
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Tuunanen, H. Helena, Engblom, E., Airaksinen, K.E.J., Nuutila, P., Hesse, B., Ukkonen, H., Opie, L., and Knuuti, J.
- Published
- 2007
- Full Text
- View/download PDF
48. 29.16: The effect of acute FFA availability limitation on cardiac function and efficiency in patients with idiopathic dilated cardiomyopathy and heart failure
- Author
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Ukkonen, H., Tuunanen, H., Engblom, E., Opie, L., Airaksinen, J., and Knuuti, J.
- Published
- 2006
- Full Text
- View/download PDF
49. Listeria monocytogenes arthritis of several joints.
- Author
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Ukkonen, H. J., Vuori, K. P., Lehtonen, O. P., and Kotilainen, P. M.
- Published
- 1995
- Full Text
- View/download PDF
50. 361 Association of quantitative myocardial perfusion characteristics and coronary atherosclerosis in patients with normal myocardial blood flow.
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Maaniitty, T, Stenstrom, I, Harjulahti, E, Maki, M, Kajander, S, Ukkonen, H, Saraste, A, and Knuuti, J
- Subjects
CORONARY heart disease risk factors ,CONFERENCES & conventions ,CORONARY circulation ,PERFUSION ,RADIONUCLIDE imaging - Published
- 2019
- Full Text
- View/download PDF
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