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3. Listeria monocytogenes induces mast cell extracellular traps

Author

Campillo-Navarro, Marcia, Leyva-Paredes, Kahiry, Donis-Maturano, Luis, González-Jiménez, Marco, Paredes-Vivas, Yuriria, Cerbulo-Vázquez, Arturo, Serafín-López, Jeanet, García-Pérez, Blanca, Ullrich, Stephen E., Flores-Romo, Leopoldo, Pérez-Tapia, Sonia M., Estrada-Parra, Sergio, Estrada-García, Iris, and Chacón-Salinas, Rommel

Published
2017
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5. Supplementary Table S1 from CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

Author

Chen, Limo, primary, Diao, Lixia, primary, Yang, Yongbin, primary, Yi, Xiaohui, primary, Rodriguez, B. Leticia, primary, Li, Yanli, primary, Villalobos, Pamela A., primary, Cascone, Tina, primary, Liu, Xi, primary, Tan, Lin, primary, Lorenzi, Philip L., primary, Huang, Anfei, primary, Zhao, Qiang, primary, Peng, Di, primary, Fradette, Jared J., primary, Peng, David H., primary, Ungewiss, Christin, primary, Roybal, Jonathon, primary, Tong, Pan, primary, Oba, Junna, primary, Skoulidis, Ferdinandos, primary, Peng, Weiyi, primary, Carter, Brett W., primary, Gay, Carl M., primary, Fan, Youhong, primary, Class, Caleb A., primary, Zhu, Jingfen, primary, Rodriguez-Canales, Jaime, primary, Kawakami, Masanori, primary, Byers, Lauren Averett, primary, Woodman, Scott E., primary, Papadimitrakopoulou, Vassiliki A., primary, Dmitrovsky, Ethan, primary, Wang, Jing, primary, Ullrich, Stephen E., primary, Wistuba, Ignacio I., primary, Heymach, John V., primary, Qin, F. Xiao-Feng, primary, and Gibbons, Don L., primary

Published
2023
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6. Data from CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

Author

Chen, Limo, primary, Diao, Lixia, primary, Yang, Yongbin, primary, Yi, Xiaohui, primary, Rodriguez, B. Leticia, primary, Li, Yanli, primary, Villalobos, Pamela A., primary, Cascone, Tina, primary, Liu, Xi, primary, Tan, Lin, primary, Lorenzi, Philip L., primary, Huang, Anfei, primary, Zhao, Qiang, primary, Peng, Di, primary, Fradette, Jared J., primary, Peng, David H., primary, Ungewiss, Christin, primary, Roybal, Jonathon, primary, Tong, Pan, primary, Oba, Junna, primary, Skoulidis, Ferdinandos, primary, Peng, Weiyi, primary, Carter, Brett W., primary, Gay, Carl M., primary, Fan, Youhong, primary, Class, Caleb A., primary, Zhu, Jingfen, primary, Rodriguez-Canales, Jaime, primary, Kawakami, Masanori, primary, Byers, Lauren Averett, primary, Woodman, Scott E., primary, Papadimitrakopoulou, Vassiliki A., primary, Dmitrovsky, Ethan, primary, Wang, Jing, primary, Ullrich, Stephen E., primary, Wistuba, Ignacio I., primary, Heymach, John V., primary, Qin, F. Xiao-Feng, primary, and Gibbons, Don L., primary

Published
2023
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7. Supplementary Methods; Figures S1 - S22; Tables S2, S6, S9 - S12 from CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

Author

Chen, Limo, primary, Diao, Lixia, primary, Yang, Yongbin, primary, Yi, Xiaohui, primary, Rodriguez, B. Leticia, primary, Li, Yanli, primary, Villalobos, Pamela A., primary, Cascone, Tina, primary, Liu, Xi, primary, Tan, Lin, primary, Lorenzi, Philip L., primary, Huang, Anfei, primary, Zhao, Qiang, primary, Peng, Di, primary, Fradette, Jared J., primary, Peng, David H., primary, Ungewiss, Christin, primary, Roybal, Jonathon, primary, Tong, Pan, primary, Oba, Junna, primary, Skoulidis, Ferdinandos, primary, Peng, Weiyi, primary, Carter, Brett W., primary, Gay, Carl M., primary, Fan, Youhong, primary, Class, Caleb A., primary, Zhu, Jingfen, primary, Rodriguez-Canales, Jaime, primary, Kawakami, Masanori, primary, Byers, Lauren Averett, primary, Woodman, Scott E., primary, Papadimitrakopoulou, Vassiliki A., primary, Dmitrovsky, Ethan, primary, Wang, Jing, primary, Ullrich, Stephen E., primary, Wistuba, Ignacio I., primary, Heymach, John V., primary, Qin, F. Xiao-Feng, primary, and Gibbons, Don L., primary

Published
2023
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17. Cis-urocanic acid: a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-H[T.sub.2A] receptor

Author

Walterscheid, Jeffrey P., Nghiem, Dat X., Kazimi, Nasser, Nutt, Leta K., McConkey, David J., Norval, Mary, and Ullrich, Stephen E.

Subjects
Inflammation -- Causes of, Serotonin -- Research, Ultraviolet radiation -- Health aspects, Immune response -- Regulation, Immune response -- Research, Science and technology
Abstract

Exposure to UV radiation induces skin cancer and suppresses the immune response. To induce immune suppression, the electromagnetic energy of UV radiation must be absorbed by an epidermal photoreceptor and converted into a biologically recognizable signal. Two photoreceptors have been recognized: DNA and transurocanic acid (UCA). Trans-UCA is normally found in the outermost layer of skin and isomerizes to the cis isomer upon exposure to UV radiation. Although UCA was identified as a UV photoreceptor years ago, and many have documented its ability to induce immune suppression, its exact mode of action remains elusive. Particularly vexing has been the identity of the molecular pathway by which cis-UCA mediates immune suppression. Here we provide evidence that cis-UCA binds to the serotonin [5-hydroxytryptamine (5-HT)] receptor with relatively high affinity (Kd = 4.6 nM). Anti-cis-UCA antibody precipitates radiolabeled 5-HT, and the binding is inhibited by excess 5-HT and/or excess cis-UCA. Similarly, anti-5-HT antibody precipitates radiolabeled cis-UCA, and the binding is inhibited by excess 5-HT or excess cis-UCA. Calcium mobilization was activated when a mouse fibrobiast line, stably transfected with the human 5-[HT.sub.2A] receptor, was treated with cis-UCA. CisUCA-induced calcium mobilization was blocked with a selective S-HT2A receptor antagonist. UV- and cis-UCA-induced immune suppression was blocked by antiserotonin antibodies or by treating the mice with 5-HT2A receptor antagonists. Our findings identify cis-UCA as a serotonin receptor ligand and indicate that the immunosuppressive effects of cis-UCA and UV radiation are mediated by activation of the 5-[HT.sub.2A] receptor. immune regulation | inflammation | serotonin | UV radiation

Published
2006

37. Induction of B-cell lymphoma by UVB Radiation in p53 Haploinsufficient Mice

Author

Ullrich Stephen E, Kazimi Nasser, Limón-Flores Alberto Y, Coimbatore Sreevidya, Miyahara Yasuko, Puebla-Osorio Nahum, and Zhu Chengming

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The incidence of non-Hodgkin's lymphoma has increased over recent years. The exact etiology of lymphoma remains unknown. Ultraviolet light exposure has been associated with the development of internal lymphoid malignancies and some reports suggest that it may play a role in the development of lymphoma in humans. Here we describe the characterization and progression of lymphoma in p53 heterozygous mice exposed to UVB irradiation. Methods UVB-irradiated p53+/- mice developed enlargement of the spleen. Isolated spleen cells were transplanted into Rag deficient hosts. The UV-induced tumor cells were analyzed by flow cytometry. The tumor cells were tagged with GFP to study their metastatic potential. SKY and karyotypic analysis were carried out for the detection of chromosomal abnormalities. Functional assays included in vitro class switch recombination assay, immunoglobulin rearrangement assay, as well as cytokine profiling. Results UVB-exposed mice showed enlargement of the spleen and lymph nodes. Cells transplanted into Rag deficient mice developed aggressive tumors that infiltrated the lymph nodes, the spleen and the bone marrow. The tumor cells did not grow in immune competent syngeneic C57Bl/6 mice yet showed a modest growth in UV-irradiated B6 mice. Phenotypic analysis of these tumor cells revealed these cells are positive for B cell markers CD19+, CD5+, B220+, IgM+ and negative for T cell, NK or dendritic cell markers. The UV-induced tumor cells underwent robust in vitro immunoglobulin class switch recombination in response to lipopolysaccharide. Cytogenetic analysis revealed a t(14;19) translocation and trisomy of chromosome 6. These tumor cells secret IL-10, which can promote tumor growth and cause systemic immunosuppression. Conclusion UV-irradiated p53+/- mice developed lymphoid tumors that corresponded to a mature B cell lymphoma. Our results suggest that an indirect mechanism is involved in the development of internal tumors after chronic exposure to UV light. The induction of B cell lymphoma in UV-irradiated p53 heterozygous mice may provide a useful model for lymphoma development in humans.

Published
2011
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46. CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade

Author

Chen, Limo, primary, Diao, Lixia, additional, Yang, Yongbin, additional, Yi, Xiaohui, additional, Rodriguez, B. Leticia, additional, Li, Yanli, additional, Villalobos, Pamela A., additional, Cascone, Tina, additional, Liu, Xi, additional, Tan, Lin, additional, Lorenzi, Philip L., additional, Huang, Anfei, additional, Zhao, Qiang, additional, Peng, Di, additional, Fradette, Jared J., additional, Peng, David H., additional, Ungewiss, Christin, additional, Roybal, Jonathon, additional, Tong, Pan, additional, Oba, Junna, additional, Skoulidis, Ferdinandos, additional, Peng, Weiyi, additional, Carter, Brett W., additional, Gay, Carl M., additional, Fan, Youhong, additional, Class, Caleb A., additional, Zhu, Jingfen, additional, Rodriguez-Canales, Jaime, additional, Kawakami, Masanori, additional, Byers, Lauren Averett, additional, Woodman, Scott E., additional, Papadimitrakopoulou, Vassiliki A., additional, Dmitrovsky, Ethan, additional, Wang, Jing, additional, Ullrich, Stephen E., additional, Wistuba, Ignacio I., additional, Heymach, John V., additional, Qin, F. Xiao-Feng, additional, and Gibbons, Don L., additional

Published
2018
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47. Mycobacterium tuberculosis Catalase Inhibits the Formation of Mast Cell Extracellular Traps

Author

Campillo-Navarro, Marcia, primary, Leyva-Paredes, Kahiry, additional, Donis-Maturano, Luis, additional, Rodríguez-López, Gloria M., additional, Soria-Castro, Rodolfo, additional, García-Pérez, Blanca Estela, additional, Puebla-Osorio, Nahum, additional, Ullrich, Stephen E., additional, Luna-Herrera, Julieta, additional, Flores-Romo, Leopoldo, additional, Sumano-López, Héctor, additional, Pérez-Tapia, Sonia M., additional, Estrada-Parra, Sergio, additional, Estrada-García, Iris, additional, and Chacón-Salinas, Rommel, additional

Published
2018
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48. Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression

Author

Chen, Limo, primary, Yi, Xiaohui, additional, Goswami, Sangeeta, additional, Ahn, Young-Ho, additional, Roybal, Jonathon D., additional, Yang, Yongbin, additional, Diao, Lixia, additional, Peng, Di, additional, Peng, David, additional, Fradette, Jared J., additional, Wang, Jing, additional, Byers, Lauren A., additional, Kurie, Jonathan M., additional, Ullrich, Stephen E., additional, Qin, F. Xiao-Feng, additional, and Gibbons, Don L., additional

Published
2016
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