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Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological synapse.

In reasoning about situations in which several causes lead to a common effect, a much studied and yet still not well-understood inference is that of explaining away. Assuming that the causes contribute independently to the effect, if we learn that the effect is present, then this increases the probability that one or more of the causes are present. But if we then learn that a particular cause is present, this cause “explains” the presence of the effect, and the probabilities of the other causes decrease again. People tend to show this explaining away effect in their probability judgments, but to a lesser extent than predicted by the causal structure of the situation. We investigated further the conditions under which explaining away is observed. Participants estimated the probability of a cause, given the presence or the absence of another cause, for situations in which the effect was either present or absent, and the evidence about the effect was either certain or uncertain. Responses were compared to predictions obtained using Bayesian network modeling as well as a sensitivity analysis of the size of normative changes in probability under different information conditions. One of the conditions investigated: when there is certainty that the effect is absent, is special because under the assumption of causal independence, the probabilities of the causes remain invariant, that is, there is no normative explaining away or augmentation. This condition is therefore especially diagnostic of people’s reasoning about common-effect structures. The findings suggest that, alongside earlier explanations brought forward in the literature, explaining away may occur less often when the causes are assumed to interact in their contribution to the effect, and when the normative size of the probability change is not large enough to be subjectively meaningful. Further, people struggled when given evidence against negative evidence, resembling a double negation effect.

Bayesian reasoning and decision making is widely considered normative because it minimizes prediction error in a coherent way. However, it is often difficult to apply Bayesian principles to complex real world problems, which typically have many unknowns and interconnected variables. Bayesian network modeling techniques make it possible to model such problems and obtain precise predictions about the causal impact that changing the value of one variable may have on the values of other variables connected to it. But Bayesian modeling is itself complex, and has until now remained largely inaccessible to lay people. In a large scale lab experiment, we provide proof of principle that a Bayesian network modeling tool, adapted to provide basic training and guidance on the modeling process to beginners without requiring knowledge of the mathematical machinery working behind the scenes, significantly helps lay people find normative Bayesian solutions to complex problems, compared to generic training on probabilistic reasoning. We discuss the implications of this finding for the use of Bayesian network software tools in applied contexts such as security, medical, forensic, economic or environmental decision making.

NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.

Much of what we believe we know, we know through the testimony of others (Coady, 1992). While there has been long-standing evidence that people are sensitive to the characteristics of the sources of testimony, for example in the context of persuasion, researchers have only recently begun to explore the wider implications of source reliability considerations for the nature of our beliefs. Likewise, much remains to be established concerning what factors influence source reliability. In this paper, we examine, both theoretically and empirically, the implications of using message content as a cue to source reliability. We present a set of experiments examining the relationship between source information and message content in people's responses to simple communications. The results show that people spontaneously revise their beliefs in the reliability of the source on the basis of the expectedness of a source's claim and, conversely, adjust message impact by perceived reliability; hence source reliability and message content have a bi-directional relationship. The implications are discussed for a variety of psychological, philosophical and political issues such as belief polarization and dual-route models of persuasion.

One of the most accepted findings across psychology is that people are unrealistically optimistic in their judgments of comparative risk concerning future life events-they judge negative events as less likely to happen to themselves than to the average person. Harris and Hahn (2011), however, demonstrated how unbiased (non-optimistic) responses can result in data patterns commonly interpreted as indicative of optimism due to statistical artifacts. In the current paper, we report the results of 5 studies that control for these statistical confounds and observe no evidence for residual unrealistic optimism, even observing a 'severity effect' whereby severe outcomes were overestimated relative to neutral ones (Studies 3 & 4). We conclude that there is no evidence supporting an optimism interpretation of previous results using the prevalent comparison method.

K(+) channels control transmembrane action potentials by gating open or closed in response to external stimuli. Inactivation gating, involving a conformational change at the K(+) selectivity filter, has recently been recognized as a major K(+) channel regulatory mechanism. In the K(+) channel hERG, inactivation controls the length of the human cardiac action potential. Mutations impairing hERG inactivation cause life-threatening cardiac arrhythmia, which also occur as undesired side effects of drugs. In this paper, we report atomistic molecular dynamics simulations, complemented by mutational and electrophysiological studies, which suggest that the selectivity filter adopts a collapsed conformation in the inactivated state of hERG. The selectivity filter is gated by an intricate hydrogen bond network around residues S620 and N629. Mutations of this hydrogen bond network are shown to cause inactivation deficiency in electrophysiological measurements. In addition, drug-related conformational changes around the central cavity and pore helix provide a functional mechanism for newly discovered hERG activators.

Argumentation is pervasive in everyday life. Understanding what makes a strong argument is therefore of both theoretical and practical interest. One factor that seems intuitively important to the strength of an argument is the reliability of the source providing it. Whilst traditional approaches to argument evaluation are silent on this issue, the Bayesian approach to argumentation (Hahn & Oaksford, 2007) is able to capture important aspects of source reliability. In particular, the Bayesian approach predicts that argument content and source reliability should interact to determine argument strength. In this paper, we outline the approach and then demonstrate the importance of source reliability in two empirical studies. These experiments show the multiplicative relationship between the content and the source of the argument predicted by the Bayesian framework.

In this article, we argue for the general importance of normative theories of argument strength. We also provide some evidence based on our recent work on the fallacies as to why Bayesian probability might, in fact, be able to supply such an account. In the remainder of the article we discuss the general characteristics that make a specifically Bayesian approach desirable, and critically evaluate putative flaws of Bayesian probability that have been raised in the argumentation literature.