491 results on '"Ulusoy S"'
Search Results
2. Daptomycin versus teicoplanin in the treatment of osteomyelitis: Results of the Göztepe retrospective cohort study
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Sipahi, O.R., Erdem, H.A., Kahraman, H., Kurşun, E., Suntur, B.M., Demirdal, T., Nemli, S.A., Dizbay, M., Ulug, M., Öztoprak-Cuvalci, N., Arda, B., Quliyeva, G., Tasbakan, M., Uysal, S., Sipahi, H., Aydemir, S., and Ulusoy, S.
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- 2021
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3. Fast off-line FPSE-HPLC-PDA determination of six NSAIDs in saliva samples
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Tartaglia, A., Kabir, A., D'Ambrosio, F., Ramundo, P., Ulusoy, S., Ulusoy, H.I., Merone, G.M., Savini, F., D'Ovidio, C., Grazia, U. De, Furton, K.G., and Locatelli, M.
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- 2020
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4. Relapse of minimal change disease after inactivated SARS-CoV-2 vaccination: case report
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Özkan, Gülsüm, Bayrakçı, N., Karabağ, S., Güzel, EÇ, and Ulusoy, S.
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- 2022
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5. Comparison of the effects of nasal steroids and montelukast on olfactory functions in patients with allergic rhinitis
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Dalgic, A., Dinc, M.E., Ulusoy, S., Dizdar, D., Is, A., and Topak, M.
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- 2017
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6. Comparaison des effets des corticostéroïdes par voie nasale et du montélukast sur les fonctions olfactives chez les patients atteints de rhinite allergique
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Dalgic, A., Dinc, M.E., Ulusoy, S., Dizdar, D., Is, A., and Topak, M.
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- 2017
- Full Text
- View/download PDF
7. Local allergic rhinitis - a narrative review.
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MANOLE, F., MULUK, N. BAYAR, OĞUZ, O., ULUSOY, S., SCADDING, G. K., PROKOPAKIS, E., KALOGJERA, L., ROMBAUX, P., and CINGI, C.
- Abstract
This narrative review aims to provide an up-to-date definition of local allergic rhinitis (LAR), its classification, mechanisms, comorbidities, recommendations for diagnosis and treatment, and define needs in this area. Both 'PubMed' and 'Science Direct' literature was reviewed systematically, and a manual search for studies not previously encountered in the databases was also carried out. Published studies were identified in PubMed covering the period from 1947 to 2022. The following keyword search strategy was used: (local allergic rhinitis* OR entopy* OR local Immunoglobulin E * OR nasal specific Immunoglobulin E). LAR involves Type 2 nasal inflammation with local IgE and cannot be diagnosed by systemic methods, such as skin prick or blood IgE tests. A nasal allergen challenge is necessary for diagnosis. LAR can respond to usual AR treatments, including allergen specific immunotherapy (AIT). LAR is a novel entity that requires additional investigation in terms of prevalence, proper diagnosis, treatment, and prognosis. The target outcomes and possible benefits of this review are to achieve a consensus for the study and diagnosis of LAR and increase interest in this area. [ABSTRACT FROM AUTHOR]
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- 2024
8. Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts
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Carido, M., Völkner, M., Steinheuer, Lisa Maria, Wagner, F., Kurth, T., Dumler, N., Ulusoy, S., Wieneke, S., Norniella, A.V., Golfieri, C., Khattak, S., Schönfelder, B., Scamozzi, M., Zoschke, K., Canzler, Sebastian, Hackermüller, Jörg, Ader, M., Karl, M.O., Carido, M., Völkner, M., Steinheuer, Lisa Maria, Wagner, F., Kurth, T., Dumler, N., Ulusoy, S., Wieneke, S., Norniella, A.V., Golfieri, C., Khattak, S., Schönfelder, B., Scamozzi, M., Zoschke, K., Canzler, Sebastian, Hackermüller, Jörg, Ader, M., and Karl, M.O.
- Abstract
The possible applications for human retinal organoids (HROs) derived from human induced pluripotent stem cells (hiPSC) rely on the robustness and transferability of the methodology for their generation. Standardized strategies and parameters to effectively assess, compare, and optimize organoid protocols are starting to be established, but are not yet complete. To advance this, we explored the efficiency and reliability of a differentiation method, called CYST protocol, that facilitates retina generation by forming neuroepithelial cysts from hiPSC clusters. Here, we tested seven different hiPSC lines which reproducibly generated HROs. Histological and ultrastructural analyses indicate that HRO differentiation and maturation are regulated. The different hiPSC lines appeared to be a larger source of variance than experimental rounds. Although previous reports have shown that HROs in several other protocols contain a rather low number of cones, HROs from the CYST protocol are consistently richer in cones and with a comparable ratio of cones, rods, and Müller glia. To provide further insight into HRO cell composition, we studied single cell RNA sequencing data and applied CaSTLe, a transfer learning approach. Additionally, we devised a potential strategy to systematically evaluate different organoid protocols side-by-side through parallel differentiation from the same hiPSC batches: In an explorative study, the CYST protocol was compared to a conceptually different protocol based on the formation of cell aggregates from single hiPSCs. Comparing four hiPSC lines showed that both protocols reproduced key characteristics of retinal epithelial structure and cell composition, but the CYST protocol provided a higher HRO yield. So far, our data suggest that CYST-derived HROs remained stable up to at least day 200, while single hiPSC-derived HROs showed spontaneous pathologic changes by day 200. Overall, our data provide insights into the efficiency, reproducibility, and stabil
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- 2023
9. Visual Exploratory Data Analysis of COVID-19 Pandemic: One Year After the Outbreak
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Ulusoy S, Lotfi L, and Nazir A
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education.field_of_study ,Exploratory data analysis ,Index (economics) ,Geography ,Population ,Case fatality rate ,Pandemic ,Per capita ,Developing country ,Outbreak ,education ,Demography - Abstract
BackgroundGovernments across the globe have taken different measures to handle the Covid-19 outbreak since it began in early 2020. Countries implemented various policies and restrictive measures to prevent transmission of the virus, reduce the impacts of the outbreak (i.e., individual, social, and economic), and provide effective control measures. Although it has been over one year since the outbreak started, few studies have examined the long-term effects of the pandemic. Furthermore, researchers need to examine which government intervention variables are the most, and least, effective. Such analysis is critical to determine the best practices in support of policy decisions.MethodsVisual exploratory data analysis (V-EDA) offers a user-friendly data visualization model to evaluate the impact of the pandemic. It allows one to observe visual patterns of trends. The V-EDA was conducted on one year data for the COVID-19 Pandemic, one year after the outbreak between 1 January and 31 December, 2020. The data were analyzed using the student’s t-test to verify if there was a statistical difference between two independent groups, and the Spearman test was also used to analyze the correlation coefficient between two quantitative datasets and their positive or negative inclination.FindingsWe found that high-testing countries had more cases per million than low-testing countries. For low-testing countries, however, there was a positive correlation between the testing level and the number of cases per million. This suggests that high-testing countries tested in a preventive manner while low-testing countries may have a higher number of cases than those confirmed. The poorest developing countries have reduced testing which can coincide with the reduction in new cases, which we did not observe in the high-testing countries. Among the restrictive measures analyzed, a higher population aged 70 or older and lower GDP per capita was related to a higher case fatality ratio. Restrictive measures reduce the number of new cases after four weeks, indicating the minimum time required for the measures to have a positive effect. Finally, public event cancellation, international travel control, school closing, contact tracing, and facial coverings were the most important measures to reduce virus spread. We observed that countries with the lowest number of cases had a higher stringency index.
- Published
- 2021
10. Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in 11 adult intensive care units from 10 cities of Turkey: findings of the International Nosocomial Infection Control Consortium (INICC)
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Leblebicioglu, H., Yalcin, A. N., Rosenthal, V. D., Koksal, I., Sirmatel, F., Unal, S., Turgut, H., Ozdemir, D., Ersoz, G., Uzun, C., Ulusoy, S., Esen, S., Ulger, F., Dilek, A., Yilmaz, H., Turhan, O., Gunay, N., Gumus, E., Dursun, O., Yýlmaz, G., Kaya, S., Ulusoy, H., Cengiz, M., Yilmaz, L., Yildirim, G., Topeli, A., Sacar, S., Sungurtekin, H., Uğurcan, D., Geyik, M. F., Şahin, A., Erdogan, S., Kaya, A., Kuyucu, N., Arda, B., and Bacakoglu, F.
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- 2013
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11. Relapse of minimal change disease after inactivated SARS-CoV-2 vaccination: case report
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Özkan, Gülsüm, primary, Bayrakçı, N., additional, Karabağ, S., additional, Güzel, EÇ, additional, and Ulusoy, S., additional
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- 2021
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12. Impact of a multidimensional infection control strategy on catheter-associated urinary tract infection rates in the adult intensive care units of 15 developing countries: findings of the International Nosocomial Infection Control Consortium (INICC)
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Rosenthal, V. D., Todi, S. K., Álvarez-Moreno, C., Pawar, M., Karlekar, A., Zeggwagh, A. A., Mitrev, Z., Udwadia, F. E., Navoa-Ng, J. A., Chakravarthy, M., Salomao, R., Sahu, S., Dilek, A., Kanj, S. S., Guanche-Garcell, H., Cuéllar, L. E., Ersoz, G., Nevzat-Yalcin, A., Jaggi, N., Medeiros, E. A., Ye, G., Akan, Ö. A., Mapp, T., Castañeda-Sabogal, A., Matta-Cortés, L., Sirmatel, F., Olarte, N., Torres-Hernández, H., Barahona-Guzmán, N., Fernández-Hidalgo, R., Villamil-Gómez, W., Sztokhamer, D., Forciniti, S., Berba, R., Turgut, H., Bin, C., Yang, Y., Pérez-Serrato, I., Lastra, C. E., Singh, S., Ozdemir, D., Ulusoy, S., and INICC Members
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- 2012
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13. Isolated hepatic sarcoidosis mimicking liver microabscesses: a case report
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Taşbakan, M. I., Erdem, H. A., Pullukçu, H., Yamazhan, T., Sipahi, O. R., Taşbakan, M. S., Ceylan, N., Yılmaz, F., Arda, B., and Ulusoy, S.
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- 2014
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14. Piperacillin/tazobactam vs. cefoperazone/sulbactam in adult low-risk febrile neutropenia cases
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Sipahi, O. R., Arda, B., Nazli-Zeka, A., Pullukcu, H., Tasbakan, M., Yamazhan, T., Ozkoren-Calik, S., Sipahi, H., and Ulusoy, S.
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- 2014
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15. The risk of malignancy index in discrimination of adnexal masses
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Ulusoy, S., Akbayir, O., Numanoglu, C., Ulusoy, N., Odabas, E., and Gulkilik, A.
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- 2007
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16. Evaluation of bacterial and viral aetiology in community-acquired pneumonia requiring hospitalisation with polymerase chain reaction: O176
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Caglayan-Serin, D., Pullukcu, H., Sipahi, O., Tasbakan, S., Cicek, C., Yamazhan, T., Tasbakan, M., Arda, B., Aydemir, S., and Ulusoy, S.
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- 2012
17. Nursing studentsʼ immunisation status and knowledge about viral hepatitis in Turkey: a multi-centre cross-sectional study
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Yamazhan, T., Durusoy, R., Tasbakan, M. I., Tokem, Y., Pullukcu, H., Sipahi, O. R., and Ulusoy, S.
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- 2011
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18. Mechanisms and solutions for nasal drug delivery -- a narrative review.
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ULUSOY, S., MULUK, N. BAYAR, KARPISCHENKO, S., PASSALI, G. C., NEGM, H., PASSALI, D., MILKOV, M., KOPACHEVA-BARSOVA, G., KONSTANTINIDIS, I., DILBER, M., and CINGI, C. C.
- Abstract
The aim of this paper is to review mechanisms and solutions for nasal drug delivery. Literature survey was performed via PubMed, Google Scholar, Google, and ProQuest Central database of Kirikkale University. The nasal lining presents a large area of endothelium of variable permeability and with a rich vascular supply. Advantages of this route include eliminating first-pass metabolism and being easily accessible. The nasal route enables some agents which are otherwise difficult to administer to enter the systemic circulation, for example, low molecular mass compounds with high polarity, peptides, or proteins. There are three principal factors that influence the extent to which drugs can be absorbed through the nasal lining, namely the physico-chemical characteristics of the drug molecule itself, the action of the mucociliary system within the nose, and the presence of any factors increasing nasal absorption. A key factor limiting the use of the intranasal route of administration is insufficient absorption through the nasal mucosa. A number of drugs in development cannot be administered intranasally because their bioavailability following nasal administration is too low. There has been considerable research focus on methods to enhance absorption via the nasal mucosa. In this chapter, we review the literature related to this problem and discuss potential solutions. [ABSTRACT FROM AUTHOR]
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- 2022
19. The intranasal trigeminal system: roles in rhinitis (allergic and non-allergic).
- Author
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ULUSOY, S., MULUK, N. BAYAR, SCADDING, G. K., PASSALI, G. S., DILBER, M., GEVAERT, P., PASSALI, D., RESULI, A. S., VAN GERVEN, L., KALOGJERA, L., PROKOPAKIS, E., ROMBAUX, P., HELLINGS, P., and CINGI, C. C.
- Abstract
The aim of this paper is to review intranasal trigeminal system and associated reflexes. The literature survey was performed on PubMed, ProQuest Central database of Kirikkale University and Google Scholar. The intranasal trigeminal system and associated reflexes play an important role in humans in both health and disease, including in rhinitis of non-allergic and mixed type. The intranasal trigeminal nerve provides sensory perception to the lining of the nose, supplying information on how patent the nasal airway is and responding to various chemical signals. The reflexes known to exist within the intranasal trigeminal system are nasobronchial reflex, trigemino-cardiac reflex, nasogastric reflex, and nasal cycle. The intranasal trigeminal system and its reflexes play a vital role in normal human physiology. Alterations in how this system operates may underlie multiple forms of rhinitis and more research is needed to fully understand the mechanisms involved. [ABSTRACT FROM AUTHOR]
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- 2022
20. Brucella melitensis in the aetiology of febrile neutropenia: report of two cases brucellosis and febrile neutropenia
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Arda, B., Tasbakan, M. I., Pullukcu, H., Sipahi, O. R., Aydemir, S., Buyukkececi, F., and Ulusoy, S.
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- 2007
21. Evaluation of the knowledge of hospital cleaning staff about prevention of nosocomial infections: O20
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Tasbakan, M., Calik, S., Pullukcu, H., Sipahi, O., Yamazhan, T., and Ulusoy, S.
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- 2007
22. Tissue culture positive prosthetic aortic valve Brucella endocarditis
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Tasbakan, M. I., Yamazhan, T., Arda, B., Pullukcu, H., Sipahi, O. R., Buke, C., and Ulusoy, S.
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- 2006
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23. Evaluation of different methods to detect oxacillin resistance in Staphylococcus aureus and their clinical laboratory utility
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Boşgelmez-Tnaz, G., Ulusoy, S., Ardoğan, B., and Coşkun-Ar, F.
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- 2006
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24. Vancomycin versus teicoplanin in the therapy of experimental methicillin resistant Staphylococcus aureus meningitis: P1686
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Sipahi, O., Arda, B., Yurtseven, T., Sipahi, H., Ozgiray, E., Suntur, M., and Ulusoy, S.
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- 2005
25. Evaluation of surgical prophylaxis in heart surgery: P1051
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Buke, C., Sipahi, O., Basoglu, M. Tuncel, Bascesme, E., Posacioglu, H., and Ulusoy, S.
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- 2005
26. Evaluation of postoperative nosocomial infections in a university faculty of medicine department of general surgery, Izmir
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Tasbakan, M. Isikgoz, Arda, B., Yamazhan, T., Pullukcu, H., and Ulusoy, S.
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- 2004
27. Nosocomial meningitis due to methicillin-resistant Staphylococcus aureus (MRSA): review of eight cases
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Arda, B., Yamazhan, T., Sipahi, O., Islekel, S., Buke, C., and Ulusoy, S.
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- 2004
28. Informal consultations in infectious diseases and clinical microbiology practice
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Leblebicioglu, H., Akbulut, A., Ulusoy, S., Sunbul, M., Aydin, K., Geyik, M. F., Esen, S., and Eroglu, C.
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- 2003
29. Neonicotinoid resistance of Aphis gossypii Glover, 1877 (Hemiptera: Aphididae) in cotton fields of Çukurova Region, Turkey1
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Ulusoy S., Atakan E., Di·Nçer S., and Çukurova Üniversitesi
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Aphis gossypii ,Resistance ,Neonicotinoid ,Cotton ,Biyoassay - Abstract
Cotton aphid, Aphis gossypii Glover, 1877 (Hemiptera: Aphididae), is a major pest in cotton fields. Neonicotinoids are important and highly prevalent insecticides currently used against A. gossypii and other herbivorous insect pests in the Mediterranean Region of Turkey. However, some insecticide applications against A. gossypii in the Çukurova Region have failed despite using high rates. Therefore, bioassays and enzyme analyses were conducted to determine resistance to imidacloprid and thiamethoxam in A. gossypii populations collected in 2015-2016 from cotton fields in this region. Resistance factors (RF) were 54.6 to 206.5 fold for imidacloprid and 5.7 to 65.7 fold for thiamethoxam. Populations from Kürkçüler (RF 206.5) had the highest LD50 for imidacloprid and from Körkuyu (RF 65.7) for thiamethoxam. Enzyme analysis revealed statistically higher metabolic resistance. Maximum enzyme activities were 17.8, 142.3 and 3.8 nM/min/mg protein for carboxylesterase for in Körkuyu, for glutathione S-transferase in Bahçe and for cytochrome P450 monooxygenase in Körkuyu, respectively. This study revealed the development of resistance in A.gossypii to neonicotinoid insecticides in Turkey and the need for new management strategies to break this resistance.
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- 2018
30. Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods [Toplum Kökenli Santral Sinir Sistemi Enfeksiyonlarinda Bakteriyel ve Viral Etiyolojinin Moleküler Yöntemlerle Deǧerlendirilmesi]
- Author
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Kahraman, H. and Tünger, A. and Şenol, S. and Gazi, H. and Avci, M. and Örmen, B. and Türker, N. and Atalay, S. and Köse, S. and Ulusoy, S. and Taşbakan, M.I. and Sipahi, O.R. and Yamazhan, T. and Gülay, Z. and Çavuş, S.A. and Pullukçu, H., Sabuncuoǧlu Şerefeddin Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Amasya, Turkey, Ege University, Faculty of Medicine, Department of Medical Microbiology, Izmir, Turkey, Celal Bayar University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Manisa, Turkey, Celal Bayar University, Faculty of Medicine, Department of Medical Microbiology, Manisa, Turkey, Bozyaka Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey, Ataturk Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey, Tepecik Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey, Ege University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey, Dokuz Eylul University, Faculty of Medicine, Department of Medical Microbiology, Izmir, Turkey, and Dokuz Eylul University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey
- Abstract
In this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (PCR) methods. Patients hospitalized with central nervous system infections between April 2012 and February 2014 were enrolled in the study. Demographic and clinical information of the patients were collected prospectively. Cerebrospinal fluid (CSF) samples of the patients were examined by standart bacteriological culture methods, bacterial multiplex PCR (Seeplex meningitis-B ACE Detection (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Listeria monocytogenes, Group B streptococci) and viral multiplex PCR (Seeplex meningitis-VI ACE Detection kits herpes simplex virus-1(HSV1), herpes simplex virus-2(HSV2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein Barr virus (EBV) and human herpes virus 6 (HHV6)) (Seeplex meningitis-V2 ACE Detection kit (enteroviruses)). Patients were classified as purulent meningitis, aseptic meningitis and encephalitis according to their clinical, CSF (leukocyte level, predominant cell type, protein and glucose (blood/CSF) levels) and cranial imaging results. Patients who were infected with a pathogen other than the detection of the kit or diagnosed as chronic meningitis and other diseases during the follow up, were excluded from the study. A total of 79 patients (28 feMale, 51 Male, aged 42.1 ±18.5) fulfilled the study inclusion criteria. A total of 46 patients were classified in purulent meningitis group whereas 33 were in aseptic meningitis/encephalitis group. Pathogens were detected by multiplex PCR in 41 patients. CSF cultures were positive in 10 (21.7%) patients (nine S.pneumoniae, one H.influenzae) and PCR were positive for 27 (58.6%) patients in purulent meningitis group. In this group one type of bacteria were detected in 18 patients (14 S.pneumoniae, two N.meningitidis, one H.influenzae, one Lmonocytogenes). Besides, it is noteworthy that multiple pathogens were detected such as bacteria-virus combination in eight patients and two different bacteria in one patient. In the aseptic meningitis/encephalitis group, pathogens were detected in 14 out of 33 patients; single type of viruses in 11 patients (seven enterovirus, two HSV1, one HSV2, one VZV) and two different viruses were determined in three patients. These data suggest that multiplex PCR methods may increase the isolation rate of pathogens in central nervous system infections. Existence of mixed pathogen growth is remarkable in our study. Further studies are needed for the clinical relevance of this result.
- Published
- 2017
31. Is Nurse Workforce Sufficient in Intensive Care Units in Turkey. Results
- Author
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Uyan, A, Durmus, G, Sezak, N, Pepe, F, Kaygusuz, T, Oztoprak, N, Ozdemir, K, Aksoy, F, Erol, S, Koc, MM, Oncul, A, Cagan Aktas, S, Caskurlu, H, Celebi, G, Kandemir, O, Ozger, S, Harman, R, Demiray, K, Ari, A, Alkan Ceviker, S, Esen Yildiz, I, Menekse, S, Senol, G, Sari, S, Dogan, M, Ugurlu, K, Arslan, M, Akdemir, I, Firat, P, Kurekci, Y, Caglayan, D, Ucar, M, Gozukucuk, R, Elmaslar Mert, HT, Alay, H, Erdogan, H, Demirel, A, Dogan, N, Kocak, F, Guven, E, Unsal, G, Sipahi, H, Isikgoz Tasbakan, M, Arda, B, Ulusoy, S, and Sipahi, OR
- Subjects
Infection control ,infection ,healthcare-associated infections ,health care facilities, manpower, and services ,intensive care infections ,infection control practitioner - Abstract
Introduction: In this multicenter study, we analysed the magnitude of healthcare worker (HCW) [infection control practitioner (ICP), nurses and others] workforce in hospitals participated in the study. Materials and Methods: This study was performed in 41 hospitals (with intensive care units-ICU) located in 22 cities from seven regions of Turkey. We analysed the ICP workforce, nursing and auxiliary HCW (AHCW) workforce in ICUs, number of ICU beds and occupied beds in four different days [two of which were in summer during the vacation time (August 27 and 31, 2016) and two others in autumn (October 12 and 15, 2016)]. The Turkish Ministry of Health (TMOH) requires two patients per nurse in level 3 ICUs, three patients per nurse in level 2 ICUs and five patients per nurse in level 1 ICUs. There is no standardization for the number of AHCW in ICUs. Finally, one ICP per 150 hospital beds is required by TMOH. Results: The total number of ICUs, ICU beds and ICPs were 214, 2377 and 111, respectively in he 41 participated centers. The number ICPs was adequate only in 12 hospitals. The percentage of nurses whose working experience was 2. The number of patients per other HCW was minimum 3.75 and maximum 4.89 on weekdays and on day shift while it was minimum 5.02 and maximum 7.7 on weekends or on night shift. When we compared the number of level 1, 2 and 3 ICUs with adequate nursing workforce vs inadequate nursing workforce, the p value was
- Published
- 2017
32. Hepatic involvement in epstein-barr virus and cytomegalovirus infections: Evaluation of 31 cases [Epstein-barr virus ve sitomegalovirus enfeksiyonlariında karaciğer tutulumu: 31 Olgunun değerlendirilmesi]
- Author
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Erdem H.A., Akyol D., Yamazhan T., Pullukçu H., Işikgöz Taşbakan M., Sıpahı O.R., Ulusoy S., and Ege Üniversitesi
- Subjects
Cytomegalovirus infections ,Epstein-barr virus infections ,Hepatitis - Abstract
Objective: Epstein-Barr virus (EBV)and Cytomegalovirus (CMV) are the main causes of infectious mononucleosis (IM) and IM-like sendrom in humans. In this study it was aimed to evaluate the clinical characteristics and liver enzymes changes in cases with EBV and CMV infections accompanying hepatic involvement in our department. Material and Methods: The hospital records of immune competent cases with EBV and CMV infections accompanying hepatic involvement who were followed up in our department between 2008-2016 were evaluated in terms of demographic characteristics, underlying diseases, laboratory, clinical data and treatment results retrospectively. Results: There were a total of 31 patients (19 men, 12 female) aged 27,6±10,6 (24 patients with EBV, 7 with CMV). The most common clinical symptoms were fever (27 patients 87,1%), fatigue (18 patients 58,1%), sore throat (12 patients 38,7%),vomiting (10 patients 32,3%), and swelling in the neck (9 patients 29,9%). Palpable servical lymph nodes (8 patients 25,8%) and hepatosplenomegaly (7 patients 22,5%) were the most common physical findings. Liver enzyme values on the 1st day and an average of 10 days after (10,9±5,8) (Range 3-30 day), 30 patients’ liver enyzmes follow up values are screened. All patients were hospitalized for an average of 6,9 days (±3,1, min: 3-max:20) and discharged as healthy. The icteric hepatitis was seen in 6,5% (2 patients). Conclusion: We conclude that the EBV and CMV serologic markers should be monitored as well as other hepatitis virus markers in the evaluation of cases with increased liver enzymes. © 2017 by Türkiye Klinikleri.
- Published
- 2017
33. Follow-up of chronic HBV infected patients planned chemotherapy due to solid organ malignancy [Solit organ malignitesi nedeniyle kemoterapi planlanan kronik hepatit B enfeksiyonlu hastalarin takibi]
- Author
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Erdem H.A., Pullukcu H., Tasbakan M., Sipahi O.R., Ulusoy S., Sertoz R., Uslu R., Yamazhan T., and Ege Üniversitesi
- Subjects
HBV reactivation ,Solid cancer ,virus diseases ,Chemotherapy ,digestive system diseases - Abstract
The aim of this study was to screen the patients with solid organ malignancy for HBV (Hepatitis B virus) infection before the start of chemotherapy and follow up in the oncology department of our setting. All cases admitted to oncology department for chemotherapy were screened prospectively for HBV infection and reactivation between March 2013-September 2014. A total of 225 patients were included in the study and divided into 3 groups; Group I: having recovered past HBV infection: 43 patients (19.1%), Group II: isolated Anti-HBcAg total positive: 20 patients (8.9%) and Group III: chronic HBV infection with 10 patients (4.4%). HBV reactivation developed in one (5.9%) of 17 patients in group II, and two (28.6%) of seven patients in group III while under lamivudine prophylaxis. Neither hepatitis flare by HBV reactivation nor HBV-related death were observed in our study. In the moderate endemicity areas like Turkey for HBV infection, all patients must be screened for HBV before starting of chemotherapy. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved.
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- 2017
34. Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods [Toplum Kökenli Santral Sinir Sistemi Enfeksiyonlarinda Bakteriyel ve Viral Etiyolojinin Moleküler Yöntemlerle Degerlendirilmesi]
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Kahraman H., Tünger A., Şenol S., Gazi H., Avci M., Örmen B., Türker N., Atalay S., Köse S., Ulusoy S., Taşbakan M.I., Sipahi O.R., Yamazhan T., Gülay Z., Çavuş S.A., Pullukçu H., and Ege Üniversitesi
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ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,ComputingMethodologies_PATTERNRECOGNITION ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Encephalitis ,Mixed infection ,Viral menengitis ,InformationSystems_MISCELLANEOUS ,Acute bacterial meningitis ,Polymerase chain reaction - Abstract
PubMed ID: 28929964, In this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (PCR) methods. Patients hospitalized with central nervous system infections between April 2012 and February 2014 were enrolled in the study. Demographic and clinical information of the patients were collected prospectively. Cerebrospinal fluid (CSF) samples of the patients were examined by standart bacteriological culture methods, bacterial multiplex PCR (Seeplex meningitis-B ACE Detection (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Listeria monocytogenes, Group B streptococci) and viral multiplex PCR (Seeplex meningitis-VI ACE Detection kits herpes simplex virus-1(HSV1), herpes simplex virus-2(HSV2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein Barr virus (EBV) and human herpes virus 6 (HHV6)) (Seeplex meningitis-V2 ACE Detection kit (enteroviruses)). Patients were classified as purulent meningitis, aseptic meningitis and encephalitis according to their clinical, CSF (leukocyte level, predominant cell type, protein and glucose (blood/CSF) levels) and cranial imaging results. Patients who were infected with a pathogen other than the detection of the kit or diagnosed as chronic meningitis and other diseases during the follow up, were excluded from the study. A total of 79 patients (28 feMale, 51 Male, aged 42.1 ±18.5) fulfilled the study inclusion criteria. A total of 46 patients were classified in purulent meningitis group whereas 33 were in aseptic meningitis/encephalitis group. Pathogens were detected by multiplex PCR in 41 patients. CSF cultures were positive in 10 (21.7%) patients (nine S.pneumoniae, one H.influenzae) and PCR were positive for 27 (58.6%) patients in purulent meningitis group. In this group one type of bacteria were detected in 18 patients (14 S.pneumoniae, two N.meningitidis, one H.influenzae, one Lmonocytogenes). Besides, it is noteworthy that multiple pathogens were detected such as bacteria-virus combination in eight patients and two different bacteria in one patient. In the aseptic meningitis/encephalitis group, pathogens were detected in 14 out of 33 patients; single type of viruses in 11 patients (seven enterovirus, two HSV1, one HSV2, one VZV) and two different viruses were determined in three patients. These data suggest that multiplex PCR methods may increase the isolation rate of pathogens in central nervous system infections. Existence of mixed pathogen growth is remarkable in our study. Further studies are needed for the clinical relevance of this result.
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- 2017
35. The use of an ostial stent does not increase the success rate of endoscopic dacryocystorhinostomy
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Dinc, M E, primary, Ulusoy, S, additional, Sahin, E, additional, Bozan, N, additional, Avincsal, M O, additional, Tutar, B, additional, and Uyar, Y, additional
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- 2018
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36. Potential protective effect of resveratrol on acoustic trauma: electron microscopy study
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Hanci, D., Ulusoy, S., Acar, M., Burukoglu, D., Mehtap Kutlu, Bayar Muluk, N., Cingi, C., Kırıkkale Üniversitesi, Anadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, and Kutlu, Hatice Mehtap
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Resveratrol ,otorhinolaryngologic diseases ,Acoustic trauma ,sense organs ,Light microscopy ,Scanning electron microscopy ,Transmission electron microscopy - Abstract
WOS: 000384168600022, PubMed ID: 27608909, OBJECTIVE: To investigate the potential preventive effect of resveratrol in rats exposed to acoustic trauma (AT). MATERIALS AND METHODS: In this experimental study, Wistar albino rats were divided into three groups: Group 1 (Control, n = 6), Group 2 (AT, n = 6), and Group 3 (resveratrol + AT). The rats in Group 2 were exposed to AT. The rats in Group 3 received resveratrol (300 mg/kg/day) via gavage for 7 days. On day 7, the rats were exposed to AT 10 min following resveratrol treatment. Histological sections of the cochleae were examined using light microscopy, transmission (TEM), and scanning electron microscopy (SEM). RESULTS: The cochlear hair cells, stereocilia, and Deiters' cells of the control group appeared normal in all microscopic evaluations. In Group 2, light microscopy revealed predominantly inner hair cell loss, although the outer hair cells were affected. TEM and SEM examination showed severe loss of stereocilia and SEM revealed stereocilia arranged in an asymmetric array. The cochlear structure in Group 3 appeared well preserved under the light microscope, and although TEM and SEM revealed stereocilia loss, the hair cells and stereocilia appeared near normal compared with those of Group 2. CONCLUSIONS: Resveratrol may have a protective effect against AT damage in the cochlea, most likely through its antioxidant activity. Our results may be useful for studies in humans exposed to AT and noise-induced hearing loss related to chronic exposure to occupational noise., Continuous Education and Scientific Research Association, With the exception of data collection, the preparation of this paper, including design and planning, was supported by the Continuous Education and Scientific Research Association. Only scientific support was provided; no grant or funding was received.
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- 2016
37. Tissue culture positive prosthetic aortic valveBrucella endocarditis
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Tasbakan, M. I., Yamazhan, T., Arda, B., Pullukcu, H., Sipahi, O. R., Buke, C., and Ulusoy, S.
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- 2006
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38. Do viral infections have a role in benign paroxysmal positional vertigo?
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Hanci, D., Ulusoy, S., Muluk, N. B., Cingi, C., and Kırıkkale Üniversitesi
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viruses ,otorhinolaryngologic diseases ,Benign paroxysmal positional vertigo (BPPV) ,sense organs ,season - Abstract
WOS: 000363361200007 PubMed: 26601554 Do viral infections have a role in benign paroxysmal positional vertigo? Objectives: To investigate the role of viral infection in benign paroxysmal positional vertigo (BPPV). Methods: In this retrospective study, 483 patients with BPPV were included in the study group. The control group consisted of 461 healthy subjects. In both groups, serologic analysis of viral agents (HSV1, HSV2, Herpes zoster, EBV, CMV, adenovirus, influenza, and parainfluenza virus) was performed. Results: With the exception of influenza and parainfluenza, all viral serology values were higher in the BBPV group than the control group. We also observed seasonal variation. The BPPV group exhibited elevated values for HSV1 and adenovirus in March and May, for Herpes zoster, adenovirus, and influenza in April, for HSV1 in June, and for HSV1 and CMV in September, compared to the control group. In October, the BPPV group showed increased values for all of the viruses studied, compared to the control group. Conclusion: BPPV is associated with positive viral serology, particularly during certain months of the year, mainly in spring and autumn. Viral infection might promote BPPV attacks due to the development of vestibulopathy or induce secondary BPPV via viral infection-related neurolabyrinthitis. Continuous Education and Scientific Research Association Except data collection, the preparation of this paper, including design and planning, was supported by the Continuous Education and Scientific Research Association. There was no grant or funding, only scientific support.
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- 2015
39. The place and the efficacy of infectious disease consultations in the hospitals
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Erdem, H., Kurtaran, B., Arun, O., Ylmaz, H., Çelebi, G., Özkaya, H.D., Kaya, S., Birengel, S., Güner, R., Demiroǧlu, Y.Z., Demirdal, T., Tekin-Koruk, S., Coşkun, O., Kazak, E., Çelen, M.K., Akova, M., Timurkaynak, F., Alpay, Y., Yilmaz, E., Saçar, Suzan, Aydin, A.F., Bodur, H., Elald, N., Inal, A.S., Saba, R., Tok, D., Aǧalar, C., Candevir, A., Parlak, M., Sipahi, O.R., Yilmaz, G., Koçak, N., Öncü, S., Sirmatel, F., Küçükardali, Y., Güzel-Tunçcan, O., Mete, B., Doyuk-Kartal, E., Ulcay, A., Şenol, E., Dayan, S., Leblebicioǧlu, H., Tabak, F., Gorenek, L., Ulusoy, S., Ayaz, C., Ergonul, O., Aksu, H.S.Z., and Erdem, H., Kasimpasa Hospital, Istanbul, Turkey -- Kurtaran, B., Department of Infectious Diseases, Cukurova University Faculty of Medicine, Balcali, Adana, Turkey -- Arun, O., Department of Gerontology, Akdeniz University, Antalya, Turkey -- Ylmaz, H., Ondokuz Mayis University School of Medicine, Samsun, Turkey -- Çelebi, G., Zonguldak Karaelmas University, School of Medicine, Zonguldak, Turkey -- Özkaya, H.D., Karsiyaka State Hospital, Izmir, Turkey -- Kaya, S., Karadeniz University School of Medicine, Trabzon, Turkey -- Birengel, S., Ankara University School of Medicine, Ankara, Turkey -- Güner, R., Ataturk Training and Research Hospital, Ankara, Turkey -- Demiro?lu, Y.Z., Baskent University School of Medicine, Adana, Turkey -- Demirdal, T., Kocatepe University School of Medicine, Afyon, Turkey -- Tekin-Koruk, S., Harran University School of Medicine, Sanliurfa, Turkey -- Coşkun, O., Gulhane Medical Academy, Ankara, Turkey -- Kazak, E., Cekirge State Hospital, Bursa, Turkey -- Çelen, M.K., Dicle University School of Medicine, Diyarbakir, Turkey -- Akova, M., Hacettepe University School of Medicine, Ankara, Turkey -- Timurkaynak, F., Baskent University School of Medicine, Ankara, Turkey -- Alpay, Y., Cengiz Gokcek State Hospital, Gaziantep, Turkey -- Yilmaz, E., Uludag University School of Medicine, Bursa, Turkey -- Saçar, S., Pamukkale University School of Medicine, Denizli, Turkey -- Aydin, A.F., Military Hospital, Izmir, Turkey -- Bodur, H., Numune Training and Research Hospital, Ankara, Turkey -- Elald, N., Cumhuriyet University School of Medicine, Sivas, Turkey -- Inal, A.S., Department of Infectious Diseases, Cukurova University Faculty of Medicine, Balcali, Adana, Turkey -- Saba, R., Akdeniz University School of Medicine, Antalya, Turkey -- Tok, D., Military Hospital, Kayseri, Turkey -- A?alar, C., Kirikkale University School of Medicine, Kirikkale, Turkey -- Candevir, A., Department of Infectious Diseases, Cukurova University Faculty of Medicine, Balcali, Adana, Turkey -- Parlak, M., Ataturk University School of Medicine, Erzurum, Turkey -- Sipahi, O.R., Ege University School of Medicine, Izmir, Turkey -- Yilmaz, G., Karadeniz University School of Medicine, Trabzon, Turkey -- Koçak, N., Military Hospital, Derince, Turkey -- Öncü, S., Adnan Menderes University School of Medicine, Aydin, Turkey -- Sirmatel, F., Izzet Baysal University School of Medicine, Bolu, Turkey -- Küçükardali, Y., Yeditepe University School of Medicine, Istanbul, Turkey -- Güzel-Tunçcan, O., Gazi University School of Medicine, Ankara, Turkey -- Mete, B., Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey -- Doyuk-Kartal, E., Osmangazi University School of Medicine, Eskisehir, Turkey -- Ulcay, A., Kasimpasa Hospital, Istanbul, Turkey -- Şenol, E., Gazi University School of Medicine, Ankara, Turkey -- Dayan, S., Dicle University School of Medicine, Diyarbakir, Turkey -- Leblebicio?lu, H., Ondokuz Mayis University School of Medicine, Samsun, Turkey -- Tabak, F., Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey -- Gorenek, L., Gulhane Medical Academy, Haydarpasa Hospital, Turkey -- Ulusoy, S., Ege University School of Medicine, Izmir, Turkey -- Ayaz, C., Dicle University School of Medicine, Diyarbakir, Turkey -- Ergonul, O., Marmara University School of Medicine, Istanbul, Turkey -- Aksu, H.S.Z., Department of Infectious Diseases, Cukurova University Faculty of Medicine, Balcali, Adana, Turkey
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fever ,sultamicillin ,teicoplanin ,clinical effectiveness ,medical specialist ,vancomycin ,patient referral ,review ,infectious disease specialist ,piperacillin plus tazobactam ,infection ,ceftriaxone ,leukocytosis ,medical practice ,ciprofloxacin ,consultation ,Infectious diseases ,hospital infection ,human ,non infectious disease specialist ,ceftazidime ,teamwork ,hospitals ,imipenem - Abstract
Our study aims to determine the efficacy of infectious disease consultations and the interrelations between doctors in this social laboratory. This study was conducted at 34 centers located in 22 cities across Turkey and contributed by 210 infectious disease specialists (IDSs) and 970 non-infectious disease specialists (NIDSs), totaling 1180 medical doctors. Infectious disease specialists and NIDSs have separately contributed by responding to questionnaires designed specifically for the consultation process. It appears that a satisfactory collaboration has been established between IDSs and NIDSs during the consultation practices. There are some discrepancies in the perceptions of some of the NIDSs. These are the evaluation of patients holistically, the expectation of NIDSs in critical infection cases to start the therapy immediately, losing the support of drug companies by NIDSs, and the restriction of NIDSs in routine medical practice. On the other hand, NIDSs seem to have real problems in the diagnosis or treatment of infectious diseases. The consultation service provided by the IDSs in Turkey is widely accepted among other clinicians and appears to be of a crucial importance. Copyright © 2012 by Lippincott Williams & Wilkins., Kurtaran, B.; Department of Infectious Diseases, Cukurova University Faculty of Medicine, Balcali, Adana, Turkey; email: behicekurtaran@gmail.com
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- 2012
40. Acute hepatitis B virus infection in Turkey: epidemiology and genotype distribution
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Tasova, Y, Kilic, D, Kaygusuz, S, Leblebicioglu, H, Eroglu, C, Aribas, E, Sirmatel, F, Ayaz, C, Ozsoy, MF, Cavuslu, S, Turkyilmaz, R, Tutuncu, E, Sunbul, M, Esen, S, Turan, D, Akbulut, A, Cihangiroglu, M, Aygen, B, Usluer, G, Kartal, ED, Irmak, H, Evirgen, O, Tulek, N, Yetkin, MA, Dokmetas, I, Bakir, M, Yildiz, ORHAN, Sencan, I, Yamazhan, T, Ulusoy, S, Akcam, Z, Yayli, G, Ersoz, G, Kaya, A, Saltoglu, N, Ersoy, Y, Ozgenc, O, Parlak, M, Parlak, E, Koksal, I, Caylan, R, and OMÜ
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Adult ,Male ,Microbiology (medical) ,Hepatitis B virus ,HBsAg ,Genotype ,Turkey ,genotype ,viral hepatitis ,medicine.disease_cause ,Polymerase Chain Reaction ,Orthohepadnavirus ,Prevalence ,medicine ,Humans ,Hepatitis B e Antigens ,Fulminant hepatitis ,biology ,business.industry ,Acute infection ,General Medicine ,hepatitis D virus ,Middle Aged ,Hepatitis B ,medicine.disease ,biology.organism_classification ,Virology ,Infectious Diseases ,Acute Disease ,DNA, Viral ,Female ,Hepatitis D virus ,business ,Viral hepatitis ,acute infection ,hepatitis B virus ,Polymorphism, Restriction Fragment Length - Abstract
42nd Interscience Conference on Antimicrobial Agents and Chemotherapy -- SEP 26-30, 2002 -- SAN DIEGO, CA Saltoglu, Nese/0000-0003-4239-9585; Leblebicioglu, Hakan/0000-0002-6033-8543; dokmetas, ilyas/0000-0003-3523-3923; Ersoy, Yasemin/0000-0001-5730-6682 WOS: 000221932100007 PubMed: 15191382 The aim of this study was to investigate the prevalence of hepatitis B virus (HBV) genotypes in Turkey. Epidemiological and clinical data for 158 patients with acute HBV infection from 22 medical centres in the period February 2001 to February 2002 were collected prospectively. HBV genotyping was based on analysis of restriction fragment length polymorphisms and nested PCR. There were 59 female and 99 male patients, with a mean age of 34.2 +/- 15.6 years. The most common probable transmission route was blood contact in 63 (41.1%) cases, but was unknown in 78 (49.4%) cases. The mean alanine aminotransferase level was 1718 +/- 1089 IU/L. Four of the 158 patients (2.5%) died because of fulminant hepatitis. One year after discharge, 11 (10.6%) of 103 cases were positive for hepatitis B surface antigen (HBsAg) and 80 (77.7%) were positive for anti-HBsAg. Genotype determination was unsuccessful in 11 cases because of a negative PCR; genotype D was found in the remaining 147 cases. The results suggested that acute HBV infection constitutes a significant health problem in Turkey and that genotype D is predominant.
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- 2004
41. Effects of modified atmosphere packaging on some quality attributes of a ready-to-eat salmon sushi
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Mol, S., Ucok Alakavuk, D., and Ulusoy, S.
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Chemistry ,Turkey ,Salmon ,quality ,food ,Fisheries ,Modified atmosphere packaging ,Ready-to-eat ,Sushi - Abstract
Sushi, a very popular food worldwide became a popular ready-to-eat food selling in supermarkets, but it exhibit distinct features, which are associated with microbiological hazards. Therefore, MAP technology, known to reduce aerobic bacteria in fishery products, was used to improve quality of ready-to-eat salmon sushi in this study. Salmon sushi were packaged with air (control), 50%N2 /50%CO2 (MAP-a), and 100% CO2 (MAP-b), stored at 4 ±1°C for 6 days and analyzed every day. During the study, control samples taken the lowest sensory scores. The total color change (ΔE) was lower in MAP samples comparing to controls. Likewise, mesophilic and psychrophilic aerobic bacteria counts of gas-treated samples were significantly lower. These results show the positive effect of MAP technology on the quality of salmon sushi. Regarding the improving demand to ready-to-eat sushi selling in supermarkets, this result will be useful in further studies and commercial applications.
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- 2014
42. report on device-associated infection rates in 19 cities of Turkey, data
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Leblebicioglu, H, Erben, N, Rosenthal, VD, Atasay, B, Erbay, A, Unal, S, Senol, G, Willke, A, Ozgultekin, A, Altin, N, Bakir, M, Oncul, O, Ersoz, G, Ozdemir, D, Yalcin, AN, Ozdemir, H, Yildizdas, D, Koksal, I, Aygun, C, Sirmatel, F, Sener, A, Tuna, N, Akan, OA, Turgut, H, Demiroz, AP, Kendirli, T, Alp, E, Uzun, C, Ulusoy, S, Arman, D, Ozgunes, I, Usluer, G, Kilic, A, Arsan, S, Cabadak, H, Sen, S, Gelebek, Y, Zengin, H, Topeli, A, Alper, Y, Meric, M, Azak, E, Inan, A, Turan, G, Haznedaroglu, T, Gorenek, L, Acar, A, Cesur, S, Engin, A, Kaya, A, Kuyucu, N, Geyik, MF, Aydin, OC, Erdogan, NS, Turhan, O, Gunay, N, Gumus, E, Dursun, O, Esen, S, Ulger, F, Dilek, A, Yilmaz, H, Sunbul, M, Gokmen, Z, Ozdemir, SI, Horoz, OO, Yylmaz, G, Kaya, S, Ulusoy, H, Kucukoduk, S, Ustun, C, Baysal, AI, Otkun, M, Tulunay, M, Oral, M, Unal, N, Cengiz, M, Yilmaz, L, Sacar, S, Sungurtekin, H, Ugurcan, D, Yetkin, MA, Bulut, C, Erdinc, FS, Hatipoglu, CA, Ince, E, Ciftci, E, Odek, C, Yaman, A, Karbuz, A, Aldemir, B, Kilic, AU, Arda, B, Bacakoglu, F, and Hizel, K
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infection ,Urinary tract infection ,Network ,Ventilator-associated pneumonia ,Catheter-associated urinary tract ,health care facilities, manpower, and services ,Central line-associated bloodstream infections ,Bloodstream ,VELOPING-COUNTRIES ,MULTIDIMENSIONAL APPROACH ,STRATEGY ,IMPACT ,INICC ,International Nosocomial Infection Consortium ,Turkey ,Device-associated infection ,Antibiotic resistance ,Hospital infection ,Nosocomial infection ,Healthcare-associated - Abstract
Background: Device-associated healthcare-acquired infections (DA-HAI) pose a threat to patient safety, particularly in the intensive care unit (ICU). We report the results of the International Infection Control Consortium (INICC) study conducted in Turkey from August 2003 through October 2012. Methods: A DA-HAI surveillance study in 63 adult, paediatric ICUs and neonatal ICUs (NICUs) from 29 hospitals, in 19 cities using the methods and definitions of the U.S. NHSN and INICC methods. Results: We collected prospective data from 94,498 ICU patients for 647,316 bed days. Pooled DA-HAI rates for adult and paediatric ICUs were 11.1 central line-associated bloodstream infections (CLABSIs) per 1000 central line (CL)-days, 21.4 ventilator-associated pneumonias (VAPs) per 1000 mechanical ventilator (MV)-days and 7.5 catheter-associated urinary tract infections (CAUTIs) per 1000 urinary catheter-days. Pooled DA-HAI rates for NICUs were 30 CLABSIs per 1000 CL-days, and 15.8 VAPs per 1000 MV-days. Extra length of stay (LOS) in adult and paediatric ICUs was 19.4 for CLABSI, 8.7 for VAP and 10.1 for CAUTI. Extra LOS in NICUs was 13.1 for patients with CLABSI and 16.2 for patients with VAP. Extra crude mortality was 12% for CLABSI, 19.4% for VAP and 10.5% for CAUTI in ICUs, and 15.4% for CLABSI and 10.5% for VAP in NICUs. Pooled device use (DU) ratios for adult and paediatric ICUs were 0.54 for MV, 0.65 for CL and 0.88 for UC, and 0.12 for MV, and 0.09 for CL in NICUs. The CLABSI rate was 8.5 per 1,000 CL days in the Medical Surgical ICUs included in this study, which is higher than the INICC report rate of 4.9, and more than eight times higher than the NHSN rate of 0.9. Similarly, the VAP and CAUTI rates were higher compared with U. S. NHSN (22.3 vs. 1.1 for VAP; 7.9 vs. 1.2 for CAUTI) and with the INICC report (22.3 vs. 16.5 in VAP; 7.9 vs. 5.3 in CAUTI). Conclusions: DA-HAI rates and DU ratios in our ICUs were higher than those reported in the INICC global report and in the US NHSN report.
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- 2014
43. Publication rates of Turkish medical specialty and doctorate theses on Medical Microbiology Clinical Microbiology and Infectious Diseases disciplines in international journals [Ülkemizde tibbi mikrobiyoloji, klinik mikrobiyoloji ve enfeksiyon hastaliklari dallarinda yapilan tipta uzmanlik ve doktora tezlerinin uluslararasi dergilerde yayina don¨ü¸¨sum oranlari]
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Sipahi O.R., Çaglayan Serin D., Pullukçu H., Taşbakan M., Köseli Ulu D., Yamazhan T., Arda B., Sipahi H., Ulusoy S., and Ege Üniversitesi
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ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,ComputingMethodologies_PATTERNRECOGNITION ,Thesis ,Turkey ,Bibliometrics ,Specialty ,Doctorate ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Infectious diseases ,Publication ,InformationSystems_MISCELLANEOUS ,Microbiology - Abstract
PubMed ID: 24819272, Writing a thesis is mandatory for getting a postgraduate medical degree in Turkey. Publication of the results of the thesis in an indexed journal makes the results available to researchers, however publication rate is usually low. The aim of this retrospective observational study was to investigate the publication rate of Turkish Infectious Diseases and Clinical Microbiology, Medical Microbiology specialty theses and Microbiology doctorate theses in international peer-review journals. On August 17th 2007, the thesis database of the Council of Higher Education of the Republic of Turkey (YOK) where all specialization and doctorate theses are recorded obligatorily, was searched for Infectious Diseases and Clinical Microbiology and Medical Microbiology specialty and Microbiology doctorate theses. Assuming that publication of a thesis would last at least six months, theses dated to February 2007 and after were excluded. The publication rate of those theses was found out by searching Science Citation Index-Expanded database for thesis author and supervisor between August 17-September 12, 2007. Chi-square test was used for statistical analysis. Our search yielded a total of 834 theses dated from 1997 to 2007, however 10 of them were excluded, since they were dated to February 2007 or after. It was found that the overall publication rate was 11.4% (94/824). The publication rates for Microbiology doctorate, Medical Microbiology and Infectious Diseases and Clinical Microbiology specialty theses were 13.7% (34/249), 10.7% (33/309) and 10.2% (27/266), respectively, with no statistical significance (p> 0.05). It was determined that nine (9.6%) of the 94 published theses belonged to 1997-2001 period, whereas 85 (80.4%) were in 2002-2007 period (p< 0.05). The probable reason for this increase was thought to be related with the updated criteria of YOK carried out in 2000 for academic promotions, nevertheless the publication rate of the investigated theses in international peer-review journals was still low. Thesis is an important part of specialty and doctorate education and necessitates intense work. The created knowledge usually contains important data about the country and the world. Publication of the theses supplies dissemination of new knowledge and completes the process of a scientific study. Solutions must be generated to promote the publication of specialty and doctorate theses.
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- 2014
44. The results of national newborn hearing screening (NNHS) data of 11,575 newborns from west part of Turkey
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Ulusoy, S., Ugras, H., Cingi, C., Yilmaz, H. B., Muluk, N. B., and Kırıkkale Üniversitesi
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The National Newborn Hearing Screening (NNHS) programme ,otorhinolaryngologic diseases ,Hearing loss ,Newborn - Abstract
WOS: 000352210000003 PubMed: 25392094 OBJECTIVE: In this study, we aimed to review the National Newborn Hearing Screening (NNHS) programme data obtained from Corlu, located in west part of Turkey for the last 4 years. SUBJECTS AND METHODS: A total 11575 newborns that were either born in Corlu State Hospital or referred from other Health Care Centers, between September 2009 and November 2012 were included into the study. Automated-Transient Evoked Otoacoustic Emission (A-TEOAE) test and Automated-Auditory Brainstem Response (A-ABR) were used as screening tests. When the newborn had failed at the initial A-TEOAE test, then the test was repeated after 15 days. If the same result was obtained at the second test; the newborns were referred for ENT examination. A-TEOAE and A-ABR screening tests were performed as the third stage evaluation. The failed newborns were referred for clinical ABR test. RESULTS: Out of 11575 newborns, 593 (5.12%) had failed the test and they were referred for clinical ABR. Out of these 593 neonates, 470 had passed the diagnostic ABR test at the referral center. Bilateral and unilateral sensori-neural hearing loss (SNHL) was detected at 15 and 7 babies respectively, 10 of 22 of these babies had risk factors such as family history of hearing loss, and parental consanguinity. CONCLUSIONS: The final hearing impairment and risk factor rates of our study was similar with literature. Although referral rates and the number of default babies gradually decreased in the last 4 years; definitive diagnosis and hearing aid initiation times need to improvement. Continuous Education and Scientific Research Association Except data collection, preparation of this paper including design and planning was supported by Continuous Education and Scientific Research Association.
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- 2014
45. Identifying gene-environment interactions in schizophrenia: Contemporary challenges for integrated, large-scale investigations
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Van Os, J. Rutten, B.P. Myin-Germeys, I. Delespaul, P. Viechtbauer, W. Van Zelst, C. Bruggeman, R. Reininghaus, U. Morgan, C. Murray, R.M. Di Forti, M. McGuire, P. Valmaggia, L.R. Kempton, M.J. Gayer-Anderson, C. Hubbard, K. Beards, S. Stilo, S.A. Onyejiaka, A. Bourque, F. Modinos, G. Tognin, S. Calem, M. O'Donovan, M.C. Owen, M.J. Holmans, P. Williams, N. Craddock, N. Richards, A. Humphreys, I. Meyer-Lindenberg, A. Leweke, F.M. Tost, H. Akdeniz, C. Rohleder, C. Bumb, J.M. Schwarz, E. Alptekin, K. Üçok, A. Saka, M.C. Atbagoǧlu, E.C. Gülöksüz, S. Gumus-Akay, G. Cihan, B. Karadaǧ, H. Soygür, H. Cankurtaran, E.S. Ulusoy, S. Akdede, B. Binbay, T. Ayer, A. Noyan, H. Karadayi, G. Akturan, E. Ulaş, H. Arango, C. Parellada, M. Bernardo, M. Sanjuán, J. Bobes, J. Arrojo, M. Santos, J.L. Cuadrado, P. Solano, J.J.R. Carracedo, A. Bernardo, E.G. Roldán, L. López, G. Cabrera, B. Cruz, S. Mesa, E.M.D. Pouso, M. Jiménez, E. Sánchez, T. Rapado, M. González, E. Martínez, C. Sánchez, E. Olmeda, M.S. De Haan, L. Velthorst, E. Van Der Gaag, M. Selten, J.-P. Van Dam, D. Van Der Ven, E. Van Der Meer, F. Messchaert, E. Kraan, T. Burger, N. Leboyer, M. Szoke, A. Schürhoff, F. Llorca, P.-M. Jamain, S. Tortelli, A. Frijda, F. Vilain, J. Galliot, A.-M. Baudin, G. Ferchiou, A. Richard, J.-R. Bulzacka, E. Charpeaud, T. Tronche, A.-M. De Hert, M. Van Winkel, R. Decoster, J. Derom, C. Thiery, E. Stefanis, N.C. Sachs, G. Aschauer, H. Lasser, I. Winklbaur, B. Schlögelhofer, M. Riecher-Rössler, A. Borgwardt, S. Walter, A. Harrisberger, F. Smieskova, R. Rapp, C. Ittig, S. Soguel-Dit-Piquard, F. Studerus, E. Klosterkötter, J. Ruhrmann, S. Paruch, J. Julkowski, D. Hilboll, D. Sham, P.C. Cherny, S.S. Chen, E.Y.H. Campbell, D.D. Li, M. Romeo-Casabona, C.M. Cirión, A.E. Mora, A.U. Jones, P. Kirkbride, J. Cannon, M. Rujescu, D. Tarricone, I. Berardi, D. Bonora, E. Seri, M. Marcacci, T. Chiri, L. Chierzi, F. Storbini, V. Braca, M. Minenna, M.G. Donegani, I. Fioritti, A. La Barbera, D. La Cascia, C.E. Mulè, A. Sideli, L. Sartorio, R. Ferraro, L. Tripoli, G. Seminerio, F. Marinaro, A.M. McGorry, P. Nelson, B. Amminger, G.P. Pantelis, C. Menezes, P.R. Del-Ben, C.M. Tenan, S.H.G. Shuhama, R. Ruggeri, M. Tosato, S. Lasalvia, A. Bonetto, C. Ira, E. Nordentoft, M. Krebs, M.-O. Barrantes-Vidal, N. Cristóbal, P. Kwapil, T.R. Brietzke, E. Bressan, R.A. Gadelha, A. Maric, N.P. Andric, S. Mihaljevic, M. Mirjanic, T.
- Abstract
Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. © 2014 The Author.
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- 2014
46. Supraclavicular Neuropathy after Surgical Treatment of Clavicular Fractures: Comparison of Two Incisions
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Erdogan, M., Desteli, E. E., Imren, Y., Mesut Kilic, Ulusoy, S., Varli, A., and Ondokuz Mayıs Üniversitesi
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Adult ,Male ,supraclavicular neuropathy ,Electrodiagnosis ,clavicular fractures ,Recovery of Function ,Clavicle ,Hypesthesia ,Fracture Fixation, Internal ,Fractures, Bone ,Treatment Outcome ,Humans ,Female ,Range of Motion, Articular ,Bone Plates - Abstract
KILIC, MESUT/0000-0002-1562-7629 WOS: 000347666000005 PubMed: 25651293 PURPOSE OF THE STUDY To compare the clinical results of clavicular fractures operated by superior locking plate using either horizontal or vertical incision by physical examination and nerve conduction tests. MATERIAL AND METHODS Between January 2010 and January 2013, 63 patients with displaced midshaft clavicle fracture were treated with superior locking plate (22 female, 41 male) with either horizontal (n = 38) or vertical incisions (n = 25). Mean interval between trauma and surgery was 3 days (1 to 8 days). Electrodiagnostic tests were performed to 15 patients who felt numbness across their shoulder or chest and ASES test was performed to each of the patient 12 weeks postoperatively. IBM SPSS Statistics 22 (IBM SPSS, Turkiye) programme was used for statistical analysis. Student t-test was used for comparison of normally distributed parameters (quantity) and continuity (Yates) test was used. p < 0.05 was accepted to be statistically significant. RESULTS 8 patients of the horizontal incision group and 7 patients of the vertical incision group described numbness across their shoulders. 14 patients had abnormal sensorial electrodiagnostic findings. Comparison of electrodiagnostic findings did not reveal any statistical significance. The mean ASES score of the affected shoulder was 76.39 +/- 1.20 in the horizontal group, in the vertical group it was found to be 79.00 +/- 2.5 ( p < 0.01). CONCLUSIONS Electrodiagnostic study revealed similar results in both groups. According to these results, significant difference in mean ASES scores of both groups was not related to sensorial injury.of the supraclavicular nerve.
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- 2014
47. International Nosocomial Infection Control Consortium (INICC) national report on device-associated infection rates in 19 cities of Turkey, data summary for 2003-2012
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Leblebicioglu, H., Erben, N., Rosenthal, V.D., Atasay, B., Erbay, A., Unal, S., Senol, G., Willke, A., Özgültekin, A., Altin, N., Bakir, M., Oncul, O., Ersöz, G., Ozdemir, D., Yalcin, A.N., Özdemir, H., Yıldızdaş, D., Koksal, I., Aygun, C., Sirmatel, F., Sener, A., Tuna, N., Akan, Ö.A., Turgut, H., Demiroz, A.P., Kendirli, T., Alp, E., Uzun, C., Ulusoy, S., Arman, D., Ozgunes, I., Usluer, G., Kiliç, A., Arsan, S., Cabadak, H., Sen, S., Gelebek, Y., Zengin, H., Topeli, A., Alper, Y., Meric, M., Azak, E., İnan, A., Turan, G., Haznedaroglu, T., Gorenek, L., Acar, A., Cesur, S., Engin, A., Kaya, A., Kuyucu, N., Geyik, M.F., Aydın, Ö.Ç., Erdogan, N.S., Turhan, O., Gunay, N., Gumus, E., Dursun, O., Esen, S., Ulger, F., Dilek, A., Yilmaz, H., Sunbul, M., Gökmen, Z., Özdemir, S.İ., Horoz, O.O., Yýlmaz, G., Kaya, S., Ulusoy, H., Küçüködük, S., Ustun, C., Otkun, M., Tulunay, M., Oral, M., Ünal, N., Cengiz, M., Yilmaz, L., Sacar, S., Sungurtekin, H., Uğurcan, D., Yetkin, M.A., Bulut, C., Erdinc, F.S., Hatipoglu, C.A., İnce, E., Çiftçi, E., Ödek, Ç., Yaman, A., Karbuz, A., Aldemir, B., Kılıc, A.U., Arda, B., Bacakoglu, F., and Hizel, K.
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Male ,Turkey ,healthcare associated infection ,Antibiotic resistance ,health care facilities, manpower, and services ,central venous catheter ,Network ,intensive care unit ,preschool child ,Turkey (republic) ,Cohort Studies ,Nosocomial infection ,newborn ,device infection ,Prevalence ,Prospective Studies ,Child ,intensive care ,catheter infection ,Urinary tract infection ,Cross Infection ,adult ,Pneumonia, Ventilator-Associated ,INICC ,cohort analysis ,infection control ,Device-associated infection ,female ,Equipment and Supplies ,Child, Preschool ,disease surveillance ,devices ,prospective study ,Adolescent ,Catheter-associated urinary tract infection ,infection rate ,Bloodstream infection ,Article ,critically ill patient ,length of stay ,Ventilator-associated pneumonia ,Humans ,Hospital infection ,human ,Healthcare-associated infection ,urinary catheter ,Infant, Newborn ,Infant ,International Nosocomial Infection Consortium ,mechanical ventilator ,major clinical study ,mortality ,Catheter-Related Infections ,ventilator associated pneumonia ,Central line-associated bloodstream infections - Abstract
Background: Device-associated healthcare-acquired infections (DA-HAI) pose a threat to patient safety, particularly in the intensive care unit (ICU). We report the results of the International Infection Control Consortium (INICC) study conducted in Turkey from August 2003 through October 2012. Methods: A DA-HAI surveillance study in 63 adult, paediatric ICUs and neonatal ICUs (NICUs) from 29 hospitals, in 19 cities using the methods and definitions of the U.S. NHSN and INICC methods. Results: We collected prospective data from 94,498 ICU patients for 647,316 bed days. Pooled DA-HAI rates for adult and paediatric ICUs were 11.1 central line-associated bloodstream infections (CLABSIs) per 1000 central line (CL)-days, 21.4 ventilator-associated pneumonias (VAPs) per 1000 mechanical ventilator (MV)-days and 7.5 catheter-associated urinary tract infections (CAUTIs) per 1000 urinary catheter-days. Pooled DA-HAI rates for NICUs were 30 CLABSIs per 1000 CL-days, and 15.8 VAPs per 1000 MV-days. Extra length of stay (LOS) in adult and paediatric ICUs was 19.4 for CLABSI, 8.7 for VAP and 10.1 for CAUTI. Extra LOS in NICUs was 13.1 for patients with CLABSI and 16.2 for patients with VAP. Extra crude mortality was 12% for CLABSI, 19.4% for VAP and 10.5% for CAUTI in ICUs, and 15.4% for CLABSI and 10.5% for VAP in NICUs. Pooled device use (DU) ratios for adult and paediatric ICUs were 0.54 for MV, 0.65 for CL and 0.88 for UC, and 0.12 for MV, and 0.09 for CL in NICUs. The CLABSI rate was 8.5 per 1,000 CL days in the Medical Surgical ICUs included in this study, which is higher than the INICC report rate of 4.9, and more than eight times higher than the NHSN rate of 0.9. Similarly, the VAP and CAUTI rates were higher compared with U.S. NHSN (22.3 vs. 1.1 for VAP; 7.9 vs. 1.2 for CAUTI) and with the INICC report (22.3 vs. 16.5 in VAP; 7.9 vs. 5.3 in CAUTI). Conclusions: DA-HAI rates and DU ratios in our ICUs were higher than those reported in the INICC global report and in the US NHSN report. © 2014 Leblebicioglu et al.
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- 2014
48. MP014THE RELATIONSHIP OF DERMATOLOGICAL FINDINGS WITH SERUM IL-31 AND UDP GLUCOSE CERAMIDE GLUCOSYLTRANSFERASE LEVELS AMONG CHRONIC KIDNEY DISEASE PATIENTS.
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Yılmaz Güvercin, Beyhan, primary, Kaynar, Kubra, additional, Aksu Arıca, Deniz, additional, Vanizor Kural, Birgül, additional, Ulusoy, S¸ükrü, additional, Cansız, Muammer, additional, Baykal Selçuk, Leyla, additional, Akyüz, Ays¸e, additional, and Çan, Gamze, additional
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- 2016
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49. Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss
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Dinc, M E, primary, Ulusoy, S, additional, Is, A, additional, Ayan, N N, additional, Avincsal, M O, additional, Bicer, C, additional, and Erel, O, additional
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- 2016
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50. On a hyperbolic Keller-Segel system with degenerate nonlinear fractional diffusion
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Karlsen, Kenneth H., primary and Ulusoy, Süleyman, primary
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- 2016
- Full Text
- View/download PDF
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