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7. Temporal evolution of liver function parameters predicts clinical outcome in chronic heart failure patients (Bio-SHiFT Study)

Author

Klimczak-Tomaniak, D, primary, Baart, S, additional, Van Boven, N, additional, Akkerhuis, K M, additional, Constantinescu, A, additional, Kaliskan, C, additional, Simsek, S, additional, Germans, T, additional, Van Ramshorst, J, additional, Kuch, M, additional, Umans, V, additional, Boersma, E, additional, and Kardys, I, additional

Published
2022
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12. Relation between pharmacological stress ECG,(NH3)-N-13-PET/CT outcome and the occurrence of cardiac events during follow-up in women with chest pain

Author

Zant, Friso M. van der, Maurits, Wondergem, Lazarenko, S.V., Broos, Wouter A.M., Umans, V., Cornel, J.H., and Knol, R.J.J.

Subjects
All institutes and research themes of the Radboud University Medical Center, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Abstract

Contains fulltext : 223811.pdf (Publisher’s version ) (Closed access)

Published
2020

21. Irish Cardiac Society: Proceedings of the Annual General Meeting held November 1993

Author

O’Callaghan, D., Horgan, J. H., Kellett, J., Graham, J., Deb, B., Caldwell, M. T. P., O'Callaghan, P., Byrne, P. J., Hennessy, T. P. J., Crean, P., Walsh, M., Gearty, G., Boyle, D. McC, Higginson, J. D. S., Salathia, K., Chandler, R., Shah, P., Lavin, F., Daly, K., Steele, I. C., Nugent, A. M., Vallely, S. R., Campbell, N. P. S., Nicholls, D. P., Coghlan, J. G., Flitter, W. D., Daly, R., Wright, G. D., Ilsley, C. D., Slate, T., Foley, D. P., Melkert, R., Keane, D., Serruys, P. W., Foley, J. B., Sridhar, K., Brown, R. I. G., Penn, I. M., Umans, V. A., de Jaegere, P., Galvin, J., Codd, M., Hennessy, A., Leavey, S., Keelan, E., McCarthy, C., Sugrue, D., Craig, B. G., Mulholland, H. C., Kearney, P., Erbel, R., Koch, L., Ge, J., Görge, G., Meyer, J., Anderson, D., Marrinan, M., Sulke, N., Cooke, R., Jackson, G., Sowton, E., McEneaney, D. J., Anderson, J., Adgey, A. A. J., Marks, P., Walsh, T. N., Leavey, Crowley, J. J., Kenny, A., Dardas, P., Shapiro, L. M., Delanty, N., Moran, N., Catella, F., FitzGerald, G. A., Fitzgerald, D. J., Umans, V., Moore, D., Weston, A., Hughes, M., Maurer, B., Cleland, J., McGee, H. M., Graham, I., Cullen, C., Dempsey, G., Wright, G., Martin, L., MacKenzie, G., Adgey, J., Lawson, J. A., Herity, N. A., Allen, J. D., Silke, B., Northridge, D. B., Jackson, N. C., Metcalfe, M. J., Dargie, H. J., Gates, A. R. C., Huang, C. L. H., Gresham, A., Carpenter, T. A., Hall, L. D., Johnston, P. W., Jossinet, J., Imam, Z., Sheahan, R., Newman, D., Dorian, P., Meleady, R., Tan, K. S., O’Brien, C., Graham, I. H., Maderna, P., Fitzgerald, D., O'Callaghan, D. M., Rafferty, S. M., Canton, M. C., Connolly, B. F., Buchalter, M. B., Shandall, A., Rees, A., Rajan, L., Sheehan, R., Ghaisas, N., and Geraty, G.

Published
1994
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26. Serially Measured Cytokines and Cytokine Receptors in Relation to Clinical Outcome in Patients With Stable Heart Failure

Author

Bouwens, Elke, Schuurman, Anne-Sophie, Akkerhuis, Martijn, Baart, Sara, Caliskan, Kadir, Brugts, Jasper, van Ramshorst, J, Germans, T, Umans, V, Boersma, Eric, Kardys, Isabella, Bouwens, Elke, Schuurman, Anne-Sophie, Akkerhuis, Martijn, Baart, Sara, Caliskan, Kadir, Brugts, Jasper, van Ramshorst, J, Germans, T, Umans, V, Boersma, Eric, and Kardys, Isabella

Published
2020

27. Renal tubular damage and worsening renal function in chronic heart failure: Clinical determinants and relation to prognosis (Bio-SHiFT study)

Author

Brankovic, Milos, Akkerhuis, Martijn, Hoorn, Ewout, van Boven, Nick, van den Berge, Jan-Kees, Constantinescu, Alina, Brugts, Jasper, van Ramshorst, J, Germans, T, Hillege, H, Boersma, Eric, Umans, V, Kardys, Isabella, Brankovic, Milos, Akkerhuis, Martijn, Hoorn, Ewout, van Boven, Nick, van den Berge, Jan-Kees, Constantinescu, Alina, Brugts, Jasper, van Ramshorst, J, Germans, T, Hillege, H, Boersma, Eric, Umans, V, and Kardys, Isabella

Published
2020

28. Stabilization patterns and variability of hs-CRP, NT-proBNP and ST2 during 1 year after acute coronary syndrome admission: results of the BIOMArCS study

Author

Berg, Victor, Umans, V, Brankovic, Milos, Oemrawsingh, Rohit, Asselbergs, FW, van der Harst, P, Hoefer, IE, Kietselaer, B, Crijns, H, Lenderink, T, Oude Ophuis, AJ, van Schaik, Ron, Kardys, Isabella, Boersma, Eric, Akkerhuis, Martijn, Berg, Victor, Umans, V, Brankovic, Milos, Oemrawsingh, Rohit, Asselbergs, FW, van der Harst, P, Hoefer, IE, Kietselaer, B, Crijns, H, Lenderink, T, Oude Ophuis, AJ, van Schaik, Ron, Kardys, Isabella, Boersma, Eric, and Akkerhuis, Martijn

Published
2020

29. Irish cardiac society: Proceedings of annual general meeting held 20th & 21st November 1992 in Dublin Castle

Author

Cullen, C., MacKenzie, G., Adgey, J., Lavin, F., Keane, M., Forde, A., Shah, P., Gannon, F., Daly, K., McClements, B. M., McNeil, A. J., Wilson, C. M., Webb, S. W., Campbell, N. P. S., Khan, M. M., O’Murchu, B., Gersh, B. J., Bailey, K. R., Holmes, D. R., Foley, D. P., Hermans, W. R., Rensing, B. J., Vos, J., Herman, J-P, Serruys, P. W., Mannion, A., Finn, J., Grimes, H., Lonergan, M., O’Donnell, Daly, L., McGovern, E., Graham, I., Joseph, P. A., Robinson, K., Kinsella, T., Crean, P., Gearty, G., Walsh, M., Ryan, M., Clarke, R., Refsum, R., Ueland, P., Coehrane, D. J., Stewart, A. J., McEneaney, D. J., Allen, J. D., Anderson, J., Dempsey, G., Adgey, A. A. J., Casey, F. A., Mulholland, H. C., Craig, B. G., Power, R., Rooney, N., O’Keeffe, D. B., McComb, J., Wilson, C., Tan, K. S., Pye, C., McCabe, N., Hickey, N., McEneaney, D., Cochrane, D., Oslizlok, P. C., Case, C. L., Gillette, P. C., Knick, Barbara J., Henry, L. P. N., Blair, L., Gumbrielle, T., Bourke, J. P., Hilton, C. J., Campbell, R. W. F., Kearney, P. P., Fennell, F., McKiernan, S., Fennell, W., Escaned, J., Hermans, W. R, Umans, V. A., de Jaegere, P. P., de Feyter, P. J., Galvin, J., Leavey, S., Sugrue, D., Vallely, S. R., Campbell, N. P. S., Laird, J. D., Ferguson, R., Duff, S., Bridges, A. B., Pringle, T. H., McNeill, G. P., McLaren, M., Belch, J. J. F., O’Sullivan, L., Bain, H., Hunter, S., Wren, C., Hennesy, A., Codd, M., Daly, C., McCarthy, C., Carroll, K., Coakley, F., O’Mahony, S., Sullivan, P. A., Kearney, P., Higgins, T., Crowey, J. J, Donnelly, S. M., Tobin, M., FitzGerald, O., Bresnihan, B., Maurer, B. J., Quigley, P. J., Shelley, E., Collins, C., Hickey, N., ulcahy, R., Johnston, P. W., Gibson, J., Crowe, P., King, G., Freyne, P. J., Geary, G., McAdam, B., Sheahan, R., Gaylani, N. El, Simpson, A., Temperley, I., Mulcahy, F., McGee, H. M., Graham, T., Crowe, B., Horgan, J. H., McGinley, J., Hurley, J., Neligan, M., Austin, C., Cleland, J., Gladstone, D., O’Kane, H., O’Sullivan, J., Hasan, A., Hamilton, J. R. L., Hunter, S., Dark, J. H., McDaid, C. M., Phillips, A. S., Lewis, S. A., McMurray, T. J., Walsh, K. P., Abrams, S. E., Diamond, M., Clarkson, M. J., Rutsch, W., Emanuelsson, H., Danchin, N., Wijns, W., and Chappuis, F.

Published
1993
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32. IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)

Author

Berg, Victor, Haskard, DO, Fedorowski, A, Hartley, A, Kardys, Isabella, Caga-Anan, M, Akkerhuis, Martijn, Oemrawsingh, Rohit, van Geuns, Robert Jan, de Jaegere, Peter, van Mieghem, Nicolas, Regar, Evelyn, Ligthart, Jurgen, Umans, V, Serruys, PWJC, Melander, O, Boersma, Eric, Khamis, RY, University of Zurich, Khamis, Ramzi Y, National Institute for Health Research, Imperial College Healthcare Charity, British Heart Foundation, Imperial College Healthcare NHS Trust- BRC Funding, Imperial College Healthcare NHS Trust, and Cardiology

Subjects
NEAR-INFRARED SPECTROSCOPY, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], immunoglobulins, 610 Medicine & health, lipid core, Research & Experimental Medicine, intravascular ultrasound, Oxidized low density lipoprotein, Medicine, General & Internal, 1300 General Biochemistry, Genetics and Molecular Biology, General & Internal Medicine, ATHEROREMO-IVUS, ARTERY-DISEASE, necrotic core, CARDIOVASCULAR EVENTS, up, Science & Technology, 10020 Clinic for Cardiac Surgery, OXIDATION-SPECIFIC EPITOPES, Medicine, Research & Experimental, ATHEROSCLEROSIS, term follow, Atherosclerosis Biomarkers Cardiovascular disease Clinical Research Intracoronary Imaging Long, IMMUNOGLOBULIN-M, IMMUNE-COMPLEXES, FOLLOW-UP, Life Sciences & Biomedicine
Abstract

Contains fulltext : 200166.pdf (Publisher’s version ) (Open Access) Background: Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis. Objectives: We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfavorable plaque characteristics. Methods: NORDIL was a prospective study investigating adverse cardiovascular outcomes in hypertensive patients. IBIS-3 analyzed lesions in a non-culprit coronary artery with

Published
2018

34. P1640Longitudinal patterns of NT-proBNP, troponin T and CRP in relation to the dynamics of echocardiographic parameters in heart failure patients

Author

Klimczak-Tomaniak, D, primary, Van Den Berg, V, additional, Strachinaru, M, additional, Akkerhuis, K M, additional, Baart, S, additional, Caliskan, K, additional, Manintveld, O C, additional, Umans, V, additional, Geleijnse, M L, additional, Boersma, H, additional, Van Dalen, B, additional, and Kardys, I, additional

Published
2019
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37. Longitudinally Measured Fibrinolysis Factors are Strong Predictors of Clinical Outcome in Patients with Chronic Heart Failure: The Bio-SHiFT Study

Author

Berg, V.J. van den, Bouwens, E., Umans, V., Maat, M., Manintveld, O.C., Caliskan, K., Constantinescu, A.A., Mouthaan, H., Cornel, J.H., Baart, S., Akkerhuis, K.Martijn, Boersma, E., Kardys, I., Berg, V.J. van den, Bouwens, E., Umans, V., Maat, M., Manintveld, O.C., Caliskan, K., Constantinescu, A.A., Mouthaan, H., Cornel, J.H., Baart, S., Akkerhuis, K.Martijn, Boersma, E., and Kardys, I.

Abstract

Item does not contain fulltext, OBJECTIVE: This article investigates whether longitudinally measured fibrinolysis factors are associated with cardiac events in patients with chronic heart failure (CHF). METHODS: A median of 9 (interquartile range [IQR] 5-10) serial, tri-monthly blood samples per patient were prospectively collected in 263 CHF patients during a median follow-up of 2.2 (IQR 1.4-2.5) years. Seventy patients (cases) reached the composite endpoint of cardiac death, heart failure hospitalization, left ventricular assist device, or heart transplantation. From all longitudinal samples, we selected baseline samples in all patients and the last two samples before the event in cases or the last sample available in event-free patients. Herein, we measured plasminogen activator inhibitor 1 (PAI-1), tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), and soluble urokinase plasminogen activator surface receptor (suPAR). Associations between temporal biomarker patterns during follow-up and the cardiac event were investigated using a joint model. RESULTS: Cases were on average older and showed higher New York Heart Association class than those who remained event-free. They also had lower blood pressures, and were more likely to have diabetes, renal failure, and atrial fibrillation. Longitudinally measured PAI-1, uPA, and suPAR were independently associated with adverse cardiac events after correction for clinical characteristics (hazard ratio [95% confidence interval]) per standard deviation increase of 2.09 (1.28-3.45) for PAI-1, 1.91 (1.18-3.24) for uPA, and 3.96 (2.48-6.63) for suPAR. Serial measurements of tPA were not significantly associated with the event after correction for multiple testing. CONCLUSION: Longitudinally measured PAI-1, uPA, and suPAR are strongly associated with adverse cardiac events during the course of CHF. If future research confirms our results, these fibrinolytic factors may carry potential for improved, and personalized, heart failure

Published
2019

38. Repeated Echocardiograms Do Not Provide Incremental Prognostic Value to Single Echocardiographic Assessment in Minimally Symptomatic Patients with Chronic Heart Failure: Results of the Bio-SHiFT Study

Author

Berg, V.J. van den, Strachinaru, M., Akkerhuis, K.Martijn, Baart, S., Brankovic, M., Constantinescu, A.A., Cornel, J.H., Manintveld, O.C., Umans, V., Rizopoulos, D., Geleijnse, M.L., Boersma, E., Dalen, B.M. van, Kardys, I., Berg, V.J. van den, Strachinaru, M., Akkerhuis, K.Martijn, Baart, S., Brankovic, M., Constantinescu, A.A., Cornel, J.H., Manintveld, O.C., Umans, V., Rizopoulos, D., Geleijnse, M.L., Boersma, E., Dalen, B.M. van, and Kardys, I.

Abstract

Item does not contain fulltext, BACKGROUND: We aimed to compare the prognostic value of a single "baseline" echocardiogram with repeated echocardiography in stable chronic heart failure (CHF) patients. We hypothesized that repeated echocardiograms would contain incremental prognostic information. METHODS: In the prospective Bio-SHiFT study, we performed 332 echocardiograms in 106 patients during a median follow-up of 2.3 years. The endpoint comprised HF hospitalization, left ventricular (LV) assist device implantation, heart transplantation, and cardiovascular death. We compared hazard ratios (HRs; adjusted for N-terminal pro-brain natriuretic peptide) from Cox models for the first available measurement with HRs from joint models, which model individual trajectories based on the repeated measurements and link these to the time-to-event data. RESULTS: The mean age of the patients was 58.1 years; 78.3% were male, 12.6% had New York Heart Association class >II, all had reduced ejection fraction, and the most common HF etiologies were cardiomyopathies (51%) and ischemia (40%). The endpoint occurred in 25 patients. Both the single measurements and the temporal trajectories were significantly associated with the endpoint (adjusted HR Cox model [95% CI] vs adjusted HR joint model [95% CI]): LV ejection fraction, 1.47 (0.93-2.31) vs 1.77 (1.13-2.93); diastolic LV diameter, 1.64 (1.09-2.47) vs 1.68 (1.12-2.57); systolic LV diameter, 1.72 (1.10-2.69) vs 1.68 (1.13-2.63); systolic left atrial diameter, 1.88 (1.18-3.00) vs 2.60 (1.48-4.97); E/A ratio, 2.73 (1.42-5.26) vs 3.87 (1.75-10.13); and E/e' ratio, 2.30 (1.38-3.84) vs 2.99 (1.68-6.19). None of the trajectories from the investigated parameters showed worsening prior to events. CONCLUSIONS: Although single baseline or repeatedly measured echocardiographic parameters were associated with the endpoint, all parameters remained on average stable during the 2.3 years of follow-up in this largely minimally symptomatic CHF cohort. Thus, regular echocardiographi

Published
2019

40. Details on high frequency blood collection, data analysis, available material and patient characteristics in BIOMArCS

Author

Boersma, Eric, Vroegindewey, Maxime, Berg, Victor, Asselbergs, FW, van der Harst, P, Kietselaer, B, Lenderink, T, Oude Ophuis, AJ, Umans, V, de Winter, RJ, Oemrawsingh, Rohit, Akkerhuis, Martijn, Boersma, Eric, Vroegindewey, Maxime, Berg, Victor, Asselbergs, FW, van der Harst, P, Kietselaer, B, Lenderink, T, Oude Ophuis, AJ, Umans, V, de Winter, RJ, Oemrawsingh, Rohit, and Akkerhuis, Martijn

Published
2019

45. IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)

Author

Berg, V.J. van den, Haskard, D.O., Fedorowski, A., Hartley, A., Kardys, I., Caga-Anan, M., Akkerhuis, K.Martijn, Oemrawsingh, R.M., Geuns, R.J.M. van, Jaegere, P. De, Mieghem, N. van, Regar, E., Ligthart, J.M., Umans, V., Serruys, P.W., Melander, O., Boersma, E., Khamis, R.Y., Berg, V.J. van den, Haskard, D.O., Fedorowski, A., Hartley, A., Kardys, I., Caga-Anan, M., Akkerhuis, K.Martijn, Oemrawsingh, R.M., Geuns, R.J.M. van, Jaegere, P. De, Mieghem, N. van, Regar, E., Ligthart, J.M., Umans, V., Serruys, P.W., Melander, O., Boersma, E., and Khamis, R.Y.

Abstract

Contains fulltext : 200166.pdf (publisher's version ) (Open Access), Background: Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis. Objectives: We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfavorable plaque characteristics. Methods: NORDIL was a prospective study investigating adverse cardiovascular outcomes in hypertensive patients. IBIS-3 analyzed lesions in a non-culprit coronary artery with <50% stenosis using radiofrequency intravascular ultrasound (RF-IVUS) and near-infrared spectroscopy (NIRS). Imaging was repeated after a median of 386?days on rosuvastatin. Associations of antibodies with incident CHD and imaging parameters were assessed in the two sub-studies respectively. Findings: From 10,881 NORDIL patients, 87 had serum sampled at baseline and developed CHD over 4.5 years, matched to 227 controls. Higher titers of IgM anti-MDA-LDL had a protective effect on adverse outcomes, with odds ratio 0.29 (0.11, 0.76; p=0.012; p=0.016 for trend). Therefore, the effect was explored at the lesional level in IBIS-3. 143 patients had blood samples and RF-IVUS measurements available, and NIRS was performed in 90 of these. At baseline, IgM anti-MDA-LDL levels had a strong independent inverse relationship with lesional necrotic core volume (p=0.027) and percentage of plaque occupied by necrotic core (p=0.011), as well as lipid core burden index (p=0.024) in the worst 4 mm segment. Interpretation: Our study supports the hypothesis that lower circulating levels of IgM anti-MDA-LDL are associated with clinical CHD development, and for the first time relates these findings to atherosclerotic plaque characteristics that are linked to vulnerability.

Published
2018

46. P6174Serial biomarker measurements show that down-titration of RAAS inhibitors and up-titration of diuretics mark progression towards end stage heart failure: Analysis of Bio-SHIFT study

Author

Brankovic, M., primary, Akkerhuis, K.M., additional, Van Boven, N., additional, Manintveld, O., additional, Germans, T., additional, Brugts, J., additional, Caliskan, K., additional, Boersma, E., additional, Umans, V., additional, Constantinescu, A., additional, and Kardys, I., additional

Published
2017
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47. Early Invasive Versus Selective Strategy for Non–ST-Segment Elevation Acute Coronary Syndrome

Author

Hoedemaker, Niels P.G., primary, Damman, Peter, additional, Woudstra, Pier, additional, Hirsch, Alexander, additional, Windhausen, Fons, additional, Tijssen, Jan G.P., additional, de Winter, Robbert J., additional, Peters, R.J.G., additional, Dunselman, P.H.J.M., additional, Verheugt, F.W.A., additional, Janus, C.L., additional, Umans, V., additional, Bendermacher, P.E.F., additional, Michels, H.R., additional, Sadée, A., additional, Hertzberger, D., additional, Peters, R.J., additional, de Miliano, P.A.R.M., additional, Liem, A.H., additional, Tjon Joe Gin, R., additional, van der Linde, M., additional, Lok, D., additional, Hoedemaker, G., additional, Pieterse, M., additional, van den Merkhof, L., additional, Daniëls, M., additional, van Hessen, M., additional, Hermans, W., additional, Schotborgh, C.E., additional, de Zwaan, C., additional, Bredero, A., additional, de Jaegere, P., additional, Janssen, M., additional, Louwerenburg, J., additional, Veerhoek, M., additional, Schalij, M., additional, de Porto, A., additional, Zijlstra, F., additional, Winter, J., additional, de Feyter, P., additional, Robles de Medina, R., additional, Withagen, P., additional, Sedney, M., additional, Thijssen, H., additional, van Rees, C., additional, van den Bergh, P., additional, de Cock, C., additional, van ’t Hof, A., additional, Suttorp, M.J., additional, de Winter, R.J., additional, Windhausen, F., additional, Cornel, J.H., additional, Tijssen, J.G.P., additional, de Feyter, P.J., additional, Düren, D., additional, Liem, K., additional, Sanders, G.T.B., additional, Fischer, J., additional, and van Straalen, J., additional

Published
2017
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49. Twee patiënten met het syndroom van Eisenmenger behandeld met nieuwe medicijnen gericht op vasodilatatie van het longvaatbed

Author

Hamaker, M. E., Duffels, M. G. J., Reichert, C. L. A., Cornel, J. H., Mulder, B. J. M., Umans, V. A. W. M., Other departments, Cardiology, and Amsterdam Cardiovascular Sciences

Abstract

Two women with Eisenmenger syndrome, aged 63 and 45 years, presented with different symptoms: the first patient had peripheral oedema, proteinuria, progressive fatigue and cyanosis and the other had increasing dyspnoea and blue lips. The first patient was successfully treated with diuretics but experienced a collum fracture that occurred after hypovolemic collapse caused by diuretic use. She was given sildenafil and underwent hip surgery with spinal anaesthesia 10 days later. In the following weeks, the patient was haemodynamically stable but then died suddenly; no autopsy was performed. The second patient was given oxygen therapy at home and bosentan. After 6 months the symptoms of dyspnoea resolved and her 6-minute walking distance increased from 453 to 512 m. The life expectancy of patients with congenital heart disorders such as Eisenmenger syndrome has improved dramatically, due in part to the efficacy of novel agents that inhibit endothelial-cell proliferation. With these advances, treatment of these patients is no longer restricted to tertiary-care centres. Therefore, community cardiologists, pulmonologists and internists should be aware of these congenital heart disorders and the available treatment options

Published
2007

50. Nationwide claims data validated for quality assessments in acute myocardial infarction in the Netherlands.

Author

Eindhoven, D. C., van Staveren, L. N., van Erkelens, J. A., Ikkersheim, D. E., Cannegieter, S. C., Umans, V. A. W. M., Mosterd, A., van Wijngaarden, J., Schalij, M. J., and Borleffs, C. J. W.

Subjects
MYOCARDIAL infarction, CORONARY disease, MEDICAL care of cardiac patients, CARDIAC patients, THERAPEUTICS
Abstract

Introduction: Since health insurance is compulsory in the Netherlands, the centrally registered medical claims data might pose a unique opportunity to evaluate quality of (cardiac) care on a national level without additional collection of data. However, validation of these claims data has not yet been assessed. Design: Retrospective cohort study. Methods: National claims data ('national registry') were compared with data collected by patient records reviews in four representative hospitals ('validation registry'). In both registries, we extracted the national diagnosis codes for ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction of 2012 and 2013. Additionally, data on medication use at one year after acute myocardial infarction (AMI) was extracted from the Dutch pharmacy information systems and also validated by local patient records reviews. The data were compared at three stages: 1) validation of diagnosis and treatment coding; 2) validation of the hospital where follow-up has taken place; 3) validation of follow-up medical treatment after 365 days. Results: In total, 3,980 patients ('national registry') and 4,014 patients ('validation registry') were compared at baseline. After one-year follow-up, 2,776 and 2,701 patients, respectively, were evaluated. Baseline characteristics, diagnosis and individual medication were comparable between the two registries. Of all 52,672 AMI patients in the Netherlands in 2012 and 2013, 81% used aspirin, 76% used P2Y12 inhibitors, 85% used statins, 82% used beta-blockers and 74% angiotensin converting enzyme inhibitors/angiotensin II antagonists. Optimal medical treatment was achieved in 49% of the patients with AMI. Conclusion: Nationwide routinely collected claims data in patients with an acute myocardial infarction are highly accurate. This offers an opportunity for use in quality assessments of cardiac care. [ABSTRACT FROM AUTHOR]

Published
2018
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