Search

Your search keyword '"Ungvari Z"' showing total 420 results
Start Over Author "Ungvari Z"
420 results on '"Ungvari Z"'

4. New species longevity record for the northern quahog (=hard clam), Mercenaria mercenaria

Author

Ridgway, Iain D., Richardson, C.A., Enos, E., Ungvari, Z., Austad, S.N., Philipp, E.E.R., and Csiszar, Anna

Subjects
Clams -- Growth -- Research, Longevity -- Research -- Growth, Animal life cycles -- Observations -- Research -- Growth, Life spans (Biology) -- Observations -- Research -- Growth, Company growth, Biological sciences, Zoology and wildlife conservation
Abstract

ABSTRACT Twenty-two large shells (>90 mm shell height) from a sample of live collected hard shell clams, Mercenaria mercenaria, from Buzzards Bay, Woods Hole, Cape Cod, MA, were subjected to [...]

Published
2011
Full Text
View/download PDF

14. Review of Cardiovascular Effects of Fluoxetine, A Selective Serotonine Reuptake Inhibitor, Compared to Tricyclic Antidepressants

Author

Pal Pacher, Ungvari, Z., Kecskemeti, V., and Furst, S.

Subjects
Pharmacology, Depressive Disorder, Organic Chemistry, Antidepressive Agents, Tricyclic, Cardiovascular System, Biochemistry, Rats, Fluoxetine, Drug Discovery, Animals, Humans, Molecular Medicine, Rabbits, Selective Serotonin Reuptake Inhibitors
Abstract

Fluoxetine is an antidepressant drug, a potent and specific inhibitor of serotonin reuptake (SSRI). Evidence suggests that being compared with tricyclic antidepressants, fluoxetine may cause significantly fewer anticholinergic, antihistaminergic and cardiotoxic side effects in the treatment of major depressive disorders. Chronic treatment with fluoxetine was not reported to affect the electrocardiogram (ECG). There is no clinical evidence of conduction delay and very little evidence of orthostatic hypotension. In the overdosed patients fewer cardiac symptoms were reported than with tricyclic antidepressants. However, dysrhythmia (atrial fibrillation and bradycardia) and syncope associated with fluoxetine treatment and overdose were reported. Although such reports have not been common, they do raise concerns. Thus we investigated the direct cardiovascular effects of the fluoxetine in isolated heart preparations and vessels of rats and rabbits. From 10-6M to 10-4M concentrations fluoxetine showed cardiodepressant and vasodilatory effects. These effects were similar to those of previously reported on tricyclic compounds. This review is a brief summary of possible cardiovascular effects of fluoxetine and other new SSRis antidepressants from the literature based on experience of clinical studies and our experiments with fluoxetine on isolated rat and rabbit cardiac preparations and vessels. Possible explanations of the lower incidence of cardiovascular complications with fluoxetine in humans and cardiodepressant effects in vitro are discussed.

Published
1998
Full Text
View/download PDF

21. Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction, Neurovascular Uncoupling, and Cognitive Decline in Mice

Author

Tucsek, Z., primary, Toth, P., additional, Tarantini, S., additional, Sosnowska, D., additional, Gautam, T., additional, Warrington, J. P., additional, Giles, C. B., additional, Wren, J. D., additional, Koller, A., additional, Ballabh, P., additional, Sonntag, W. E., additional, Ungvari, Z., additional, and Csiszar, A., additional

Published
2014
Full Text
View/download PDF

22. Impaired Nitric Oxide-Mediated Flow-Induced Coronary Dilation in Hyperhomocysteinemia : Morphological and Functional Evidence for Increased Peroxynitrite Formation

Author

Ungvari, Z, Csiszar, A, Bagi, Z, and Koller, A

Subjects
Male, Blotting, Western, Hyperhomocysteinemia, In Vitro Techniques, Nitric Oxide, Coronary Vessels, Immunohistochemistry, Rats, Vasodilation, NG-Nitroarginine Methyl Ester, Superoxides, Coronary Circulation, Peroxynitrous Acid, Animals, Tyrosine, Enzyme Inhibitors, Rats, Wistar, Regular Articles
Abstract

Hyperhomocysteinemia (HHcy) is a newly recognized risk factor for myocardial infarction, however, the effect of HHcy on endothelium-dependent flow-induced dilation of coronary arteries is not known. Thus, changes in diameter of small intramural coronary arteries (diameter, approximately 145 microm) isolated from control rats and rats with methionine diet-induced HHcy were investigated by videomicroscopy. Increases in intraluminal flow (from 0 to 40 microl/min) elicited dilations of control vessels (maximum, 25 +/- 2 microm), responses that were absent in HHcy arteries. The nitric oxide (NO) synthase inhibitor L-NAME inhibited flow-induced dilation of control coronaries, whereas it had no effect on responses of HHcy arteries. Dilations of control and HHcy arteries to the NO donor sodium nitroprusside were not different. Responses to flow in HHcy coronary arteries were unaffected by administration of L-arginine or the prostaglandin H(2)/thromboxane A(2) receptor antagonist SQ 29,548. However, in the presence of superoxide dismutase (plus catalase) or the superoxide scavenger Tiron increases in flow elicited L-NAME-sensitive dilations of HHcy coronaries (maximum, 18 +/- 5 microm). Also, superoxide dismutase significantly reduced the enhanced superoxide production of HHcy coronaries (measured by the lucigenin chemiluminescence method). Single vessel Western blotting showed an increased tyrosine nitrosation (a stable biomarker of tissue peroxynitrite formation) in HHcy coronaries. Also, extensive prevalence of 3-nitrotyrosine immunoreactivity was observed in HHcy coronaries that was confined primarily to the subendothelial layers of smooth muscle. We propose that in HHcy an increased level of superoxide scavenges NO forming peroxynitrite, which increases protein nitrosation. The reduced bioavailability of NO impairs flow-induced dilations of coronary arteries, which may contribute to the development of coronary atherosclerosis and ischemic heart disease.

Published
2002

27. Speculations on difference between tricyclic and selective serotonin reuptake inhibitor antidepressants on their cardiac effects. Is there any?

Author

Pal Pacher, Ungvari, Z., Nanasi, P. P., Furst, S., and Kecskemeti, V.

Subjects
Pharmacology, Organic Chemistry, Guinea Pigs, Heart, Citalopram, Calcium Channel Blockers, Biochemistry, Rats, Electrophysiology, Dogs, Fluoxetine, Drug Discovery, cardiovascular system, Molecular Medicine, Animals, Antidepressive Agents, Second-Generation, Humans, Rabbits, Selective Serotonin Reuptake Inhibitors, Sodium Channel Blockers
Abstract

The cardiovascular effects and toxicity of tricyclic antidepressants (TCAs) have been well documented in medical literature. The most common manifestation of such effects is slowing of intraventricular conduction, manifested by prolonged PR, QRS and QT intervals on the standard electrocardiogram (EGG) and postural hypotension. In contrast to TCAs, selective serotonin reuptake inhibitors (SSRis), including fluoxetine and citalopram, are considered to cause less effect on cardiac impulse conduction. In addition, these compounds induced significantly less anticholinergic, antihistaminergic and cardiotoxic side-effects than TCAs. However, there is an increasing number of case reports on dysrhythmias, like atrial fibrillation or bradycardia and syncope associated with fluoxetine and another SSRI treatment and overdose. Although such reports have not been common, they do raise concerns. In cardiac tissues isolated from canine, rabbit, rat and guinea pig hearts we have found that fluoxetine and citalopram inhibited cardiac Na+ and Ca2+ channels. These direct cardiac electrophysiological effects were similar to those of observed for tricyclic antidepressants clomipramine and imipramine. The inhibition of cardiac Ca2+ and Na+ channels by fluoxetine may explain most cardiac side-effects observed occasionally with the drug and mild but significant bradycardia reported during chronic treatment. Our results suggest that fluoxetine and citalopram may have antiarrhythmic (class I + IV type), as well as proarrhythmic properties (due to impairment of atrioventricular or intraventricular conduction and shortening of repolarization). Taking all these into consideration, in depressed patients having also severe cardiac disorders, EGG control may be suggested during fluoxetine and probable another SSRI therapy. The primary goal of this review is to compare these direct cardiac effects of fluoxetine and citalopram to those of previously reported for TCAs. This paper also summarizes the recently observed effects of fluoxetine apparently not related to the blockage of 5-HT transporter based on literature.

Published
1999

29. Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

Author

Tucsek, Z., primary, Toth, P., additional, Sosnowska, D., additional, Gautam, T., additional, Mitschelen, M., additional, Koller, A., additional, Szalai, G., additional, Sonntag, W. E., additional, Ungvari, Z., additional, and Csiszar, A., additional

Published
2013
Full Text
View/download PDF

30. Ionizing Radiation Promotes the Acquisition of a Senescence-Associated Secretory Phenotype and Impairs Angiogenic Capacity in Cerebromicrovascular Endothelial Cells: Role of Increased DNA Damage and Decreased DNA Repair Capacity in Microvascular Radiosensitivity

Author

Ungvari, Z., primary, Podlutsky, A., additional, Sosnowska, D., additional, Tucsek, Z., additional, Toth, P., additional, Deak, F., additional, Gautam, T., additional, Csiszar, A., additional, and Sonntag, W. E., additional

Published
2013
Full Text
View/download PDF

34. Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype?

Author

Ungvari, Z., primary, Sosnowska, D., additional, Mason, J. B., additional, Gruber, H., additional, Lee, S. W., additional, Schwartz, T. S., additional, Brown, M. K., additional, Storm, N. J., additional, Fortney, K., additional, Sowa, J., additional, Byrne, A. B., additional, Kurz, T., additional, Levy, E., additional, Sonntag, W. E., additional, Austad, S. N., additional, Csiszar, A., additional, and Ridgway, I., additional

Published
2012
Full Text
View/download PDF

36. Testing Predictions of the Oxidative Stress Hypothesis of Aging Using a Novel Invertebrate Model of Longevity: The Giant Clam (Tridacna Derasa)

Author

Ungvari, Z., primary, Csiszar, A., additional, Sosnowska, D., additional, Philipp, E. E., additional, Campbell, C. M., additional, McQuary, P. R., additional, Chow, T. T., additional, Coelho, M., additional, Didier, E. S., additional, Gelino, S., additional, Holmbeck, M. A., additional, Kim, I., additional, Levy, E., additional, Sonntag, W. E., additional, Whitby, P. W., additional, Austad, S. N., additional, and Ridgway, I., additional

Published
2012
Full Text
View/download PDF

41. Testing the Oxidative Stress Hypothesis of Aging in Primate Fibroblasts: Is There a Correlation Between Species Longevity and Cellular ROS Production?

Author

Csiszar, A., primary, Podlutsky, A., additional, Podlutskaya, N., additional, Sonntag, W. E., additional, Merlin, S. Z., additional, Philipp, E. E. R., additional, Doyle, K., additional, Davila, A., additional, Recchia, F. A., additional, Ballabh, P., additional, Pinto, J. T., additional, and Ungvari, Z., additional

Published
2012
Full Text
View/download PDF

42. Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging

Author

Bailey-Downs, L. C., primary, Sosnowska, D., additional, Toth, P., additional, Mitschelen, M., additional, Gautam, T., additional, Henthorn, J. C., additional, Ballabh, P., additional, Koller, A., additional, Farley, J. A., additional, Sonntag, W. E., additional, Csiszar, A., additional, and Ungvari, Z., additional

Published
2011
Full Text
View/download PDF

43. Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging

Author

Bailey-Downs, L. C., primary, Mitschelen, M., additional, Sosnowska, D., additional, Toth, P., additional, Pinto, J. T., additional, Ballabh, P., additional, Valcarcel-Ares, M. N., additional, Farley, J., additional, Koller, A., additional, Henthorn, J. C., additional, Bass, C., additional, Sonntag, W. E., additional, Ungvari, Z., additional, and Csiszar, A., additional

Published
2011
Full Text
View/download PDF

45. Extreme Longevity Is Associated With Increased Resistance to Oxidative Stress in Arctica islandica, the Longest-Living Non-Colonial Animal

Author

Ungvari, Z., primary, Ridgway, I., additional, Philipp, E. E. R., additional, Campbell, C. M., additional, McQuary, P., additional, Chow, T., additional, Coelho, M., additional, Didier, E. S., additional, Gelino, S., additional, Holmbeck, M. A., additional, Kim, I., additional, Levy, E., additional, Sosnowska, D., additional, Sonntag, W. E., additional, Austad, S. N., additional, and Csiszar, A., additional

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results