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1. ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors

Author: Jane E. Aubin, Geoffrey Vargas, Edith Bonnelye, Sophie Vacher, Marie Brevet, Pascal Reboul, M Filipits, Ivan Bièche, C Boyault, W Jacot, Lamia Bouazza, Sandra Geraci, Keltouma Driouch, Francesco Pantano, Michael Gnant, Catherine Alix-Panabières, M Gervais, Laure Cayrefourcq, Philippe Clézardin, M Bouchet, M Mazel, Martine Croset, Claire Benetollo, C Kan, Martine Duterque-Coquillaud, Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases [LYOS], Institut de Génomique Fonctionnelle de Lyon [IGFL], Ingénierie Moléculaire et Physiopathologie Articulaire [IMoPA], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB], The University of Sydney, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL], Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 [AIDMP], Institut Curie [Paris], Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome [ UCBM], Medizinische Universität Wien = Medical University of Vienna, Institut de Recherche en Cancérologie de Montpellier [IRCM - U1194 Inserm - UM], Institut de biologie de Lille - IBL [IBLI], Mécanismes de tumorigenèse et thérapies ciblées, Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut Curie, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biochemistry [University of Toronto], University of Toronto, Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, This work was supported by the National Center for Scientific Research (CNRS) to EB, the National Institute of Health and Medical Research (INSERM), the University of Lyon1, La Ligue Nationale (Drôme), Inserm-Transfert (EB). GV was supported by the Labex DEVweCAN, MG, MB by the French National Cancer Institute (INCa), CK by the Marie-Curie-Individual-Fellowship (655777-miR-OMeS). CAP, LC, and MM by CANCER-ID (FP7/2007-2013) and EFPIA., The authors thank Anne Flourens, Cyprien Tilmant, Tina Louadj, and both CeCIL and ALECS platforms (Faculté de Médecine Laennec, Lyon) for their assistance., Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER], Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biochimie Générale et Médicale, INSERM-CNRS U.189 Faculté de Médecine Lyon-Sud, Centre de Recherche en Géomatique [Laval] (CRG), Université Laval, Swiss Federal Office for the Environment FOEN, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de Génétique [Institut Curie, Paris] (Unité de Pharmacogénomique), Department of Surgery, Breast Health Center, Medical University Vienna, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de biologie et chimie des protéines [Lyon] (IBCP), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Cancer Research, Breast Neoplasms/pathology, Bone Neoplasms/secondary, [SDV]Life Sciences [q-bio], MESH: Gene Expression Regulation, Neoplastic, Transcriptome, Mammary Neoplasms, Animal/genetics, Mice, 0302 clinical medicine, Circulating tumor cell, Neoplasm Proteins/genetics, MESH: Breast Neoplasms/genetics, MESH: Animals, MESH: Breast Neoplasms/metabolism, ComputingMilieux_MISCELLANEOUS, MESH: Breast Neoplasms/pathology, Mice, Inbred BALB C, Receptor Activator of Nuclear Factor-kappa B, Receptors, Estrogen/genetics, MESH: Receptor Activator of Nuclear Factor-kappa B/genetics, Metastatic breast cancer, Primary tumor, Neoplasm Proteins, 3. Good health, Gene Expression Regulation, Neoplastic, Receptors, Estrogen, RANKL, 030220 oncology & carcinogenesis, MESH: Bone Neoplasms/metabolism, Female, MESH: Bone Neoplasms/secondary, Breast Neoplasms/metabolism, MESH: Bone Neoplasms/genetics, Receptor Activator of Nuclear Factor-kappa B/biosynthesis, MESH: Mice, Inbred BALB C, Bone Neoplasms, Breast Neoplasms, Mammary Neoplasms, Animal, [SDV.CAN]Life Sciences [q-bio]/Cancer, Mammary Neoplasms, Animal/metabolism, Neoplasm Proteins/metabolism, Biology, Breast Neoplasms/genetics, 03 medical and health sciences, Breast cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Genetics, medicine, Animals, Humans, MESH: Neoplasm Proteins/genetics, MESH: Receptors, Estrogen/metabolism, MESH: Neoplasm Proteins/metabolism, MESH: Mammary Neoplasms, Animal/pathology, Mammary Neoplasms, Animal/pathology, Molecular Biology, MESH: Mice, PI3K/AKT/mTOR pathway, Receptor Activator of Nuclear Factor-kappa B/genetics, MESH: Humans, MESH: Receptors, Estrogen/genetics, Bone Neoplasms/genetics, medicine.disease, Receptors, Estrogen/metabolism, MESH: Mammary Neoplasms, Animal/genetics, 030104 developmental biology, Cancer cell, Bone Neoplasms/metabolism, Cancer research, biology.protein, MESH: Receptor Activator of Nuclear Factor-kappa B/biosynthesis, MESH: Female, Bone Neoplasms/pathology, MESH: Mammary Neoplasms, Animal/metabolism, MESH: Bone Neoplasms/pathology
Abstract: International audience; Bone is the most common metastatic site for breast cancer. Estrogen-related-receptor alpha (ERRα) has been implicated in cancer cell invasiveness. Here, we established that ERRα promotes spontaneous metastatic dissemination of breast cancer cells from primary mammary tumors to the skeleton. We carried out cohort studies, pharmacological inhibition, gain-of-function analyses in vivo and cellular and molecular studies in vitro to identify new biomarkers in breast cancer metastases. Meta-analysis of human primary breast tumors revealed that high ERRα expression levels were associated with bone but not lung metastases. ERRα expression was also detected in circulating tumor cells from metastatic breast cancer patients. ERRα overexpression in murine 4T1 breast cancer cells promoted spontaneous bone micro-metastases formation when tumor cells were inoculated orthotopically, whereas lung metastases occurred irrespective of ERRα expression level. In vivo, Rank was identified as a target for ERRα. That was confirmed in vitro in Rankl stimulated tumor cell invasion, in mTOR/pS6K phosphorylation, by transactivation assay, ChIP and bioinformatics analyses. Moreover, pharmacological inhibition of ERRα reduced primary tumor growth, bone micro-metastases formation and Rank expression in vitro and in vivo. Transcriptomic studies and meta-analysis confirmed a positive association between metastases and ERRα/RANK in breast cancer patients and also revealed a positive correlation between ERRα and BRCA1 mut carriers. Taken together, our results reveal a novel ERRα/RANK axis by which ERRα in primary breast cancer promotes early dissemination of cancer cells to bone. These findings suggest that ERRα may be a useful therapeutic target to prevent bone metastases.
Published: 2019
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2. The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation

Author: Charman, T., Loth, Eva, Tillmann, Julian, Crawley, Daisy, Wooldridge, C., Goyard, David, Ahmad, Jumana, Auyeung, Bonnie, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen,Simon, Baumeister, Sarah, Beckmann, Christian, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Y., Chakrabarti,B., Cornelissen, Ineke, Acqua, Flavio Dell, Dumas, G., Durston, Sarah, Ecker,C., Faulkner, J., Frouin, Vincent, Garces, Pilar, Ham, Lindsay M., Hayward, Hannah, Hipp, Joerg, Holt, R. J., Isaksson, Johan, Johnson, Mark H., Jones, Emily J. H., Kundu, Prantik, Lai,Meng-Chuan, D'Ardhuy, X. L., Lombardo, Michael V., Lythgoe, David J., Mandl, Rene, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan J., Persico, Antonio M., Ruggeri, B., Ruigrok,Amber N. V., Sabet, Jessica, Sacco, Roberto, Caceres, Antonia San Jose, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams,Steven C. R., Zwiers, Marcel P., Spooren, Will, Murphy,Declan G. M., Buitelaar, Jan K., Lombardo,Michael V., Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, University of Edinburgh, Autism Research Centre and Section of Developmental Psychiatry, University of Cambridge [UK] ( CAM ), University Medical Center [Utrecht], Universität Heidelberg [Heidelberg], Medizinische Fakultät Mannheim, Radboud University Medical Center [Nijmegen], Karolinska Institutet [Stockholm], Génétique humaine et Fonctions cognitives - Human Genetics and Cognitive Functions, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM ), University of Reading ( UOR ), Goethe-University Frankfurt am Main, Roche Pharma Research and Early Development [Basel] ( pRED ), F. Hoffmann-La Roche [Basel], Uppsala University, Centre for Brain and Cognitive Development [Birkbeck College], Birkbeck College [University of London], Icahn School of Medicine at Mount Sinai [New York], University of Toronto, University of Cyprus [Nicosia], Janssen Research & Development, University of Messina, This work was supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ inkind contributions, and from Autism Speaks., European Project : 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS ( 2012 ), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Cambridge [UK] (CAM), Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim], Universität Heidelberg [Heidelberg] = Heidelberg University, Stockholm County Council, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), University of Reading (UOR), Universitätsklinikum Frankfurt, Roche Pharma Research and Early Development [Basel] (pRED), University of London [London], Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Cyprus [Nicosia] (UCY), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], This work was supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions, and from Autism Speaks., European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Radboud university [Nijmegen], Lombardo, Michael V. [0000-0001-6780-8619], Charman, Tony [0000-0003-1993-6549], Loth, Eva [0000-0001-9458-9167], Tillmann, Julian [0000-0001-9574-9855], Crawley, Daisy [0000-0001-9901-1110], Ahmad, Jumana [0000-0001-5271-0731], Banaschewski, Tobias [0000-0003-4595-1144], Baron-Cohen, Simon [0000-0001-9217-2544], Brogna, Claudia [0000-0002-9526-6367], Dumas, Guillaume [0000-0002-2253-1844], Hayward, Hannah [0000-0001-5552-2146], Hipp, Joerg [0000-0002-7875-2988], Isaksson, Johan [0000-0003-1033-2618], Johnson, Mark [0000-0003-4229-2585], Jones, Emily JH [0000-0001-5747-9540], Lai, Meng-Chuan [0000-0002-9593-5508], Lythgoe, David J [0000-0002-5078-9025], Moessnang, Carolin [0000-0003-4357-2706], Ruggeri, Barbara [0000-0002-6231-8829], Ruigrok, Amber [0000-0001-7711-8056], Simonoff, Emily [0000-0002-5450-0823], Toro, Roberto [0000-0002-6671-858X], Williams, Steve CR [0000-0003-4299-1941], Murphy, Declan GM [0000-0002-6664-7451], and Apollo - University of Cambridge Repository
Subjects: Parents, Male, [SDV]Life Sciences [q-bio], Autism, [ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Individuality, Behaviours, Severity of Illness Index, lcsh:RC346-429, psyc, 0302 clinical medicine, Age, autism, autism spectrum disorder, behaviours, heterogeneity, IQ, phenotype, sex, molecular biology, developmental neuroscience, developmental biology, psychiatry and mental health, Surveys and Questionnaires, Longitudinal Studies, Autism spectrum disorder, Child, Psychiatry, Age, autism, autism spectrum disorder, behaviours, heterogeneity, IQ, phenotype, sex, molecular biology, developmental neuroscience, developmental biology, psychiatry and mental health, 05 social sciences, Neuropsychology, Age Factors, 220 Statistical Imaging Neuroscience, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognition, Psychiatry and Mental health, Phenotype, Cohort, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Sex, Psychology, 050104 developmental & child psychology, Adult, medicine.medical_specialty, Adolescent, BF, behavioral disciplines and activities, 150 000 MR Techniques in Brain Function, Psykiatri, 03 medical and health sciences, Genetic Heterogeneity, [ SHS.PSY ] Humanities and Social Sciences/Psychology, Sex Factors, Developmental Neuroscience, Severity of illness, mental disorders, medicine, Journal Article, Humans, 0501 psychology and cognitive sciences, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Research, medicine.disease, R1, Clinical trial, Impulsive Behavior, Observational study, Self Report, Heterogeneity, 030217 neurology & neurosurgery, Biomarkers, Developmental Biology
Abstract: Background The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers. Methods From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms. Results The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females. Conclusions The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials. Electronic supplementary material The online version of this article (doi:10.1186/s13229-017-0145-9) contains supplementary material, which is available to authorized users.
Published: 2017
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3. The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders

Author: Caroline Wooldridge, Marianne Oldehinkel, Claudia Brogna, Heike Tost, Eva Loth, Lindsay Ham, Laurence O'Dwyer, Thomas Bourgeron, Gahan Pandina, Amber N. V. Ruigrok, Antonio M. Persico, Sarah Durston, Michael V. Lombardo, Andreas Meyer-Lindenberg, Steve C.R. Williams, Julian Tillmann, Simon Baron-Cohen, Sarah Baumeister, Christian F. Beckmann, Tobias Banaschewski, Jumana Ahmad, Barbara Ruggeri, Jessica Sabet, Joerg F. Hipp, Daisy Crawley, Christine Ecker, Sara Ambrosino, Tony Charman, Antonia San José Cáceres, Xavier Liogier d'Ardhuy, Will Spooren, David J. Lythgoe, Nico Mueller, Guillaume Dumas, Luke Mason, Meng-Chuan Lai, Yvette de Bruijn, Sven Bölte, Prantik Kundu, Daniel Brandeis, David Goyard, Ineke Cornelissen, Emily Simonoff, Carsten Bours, Johan Isaksson, Pilar Garcés, Emily J.H. Jones, Rosemary Holt, Marcel P. Zwiers, Vincent Frouin, Roberto Sacco, Declan G. Murphy, Hannah Hayward, Roberto Toro, Jack Waldman, Bob Oranje, Carolin Moessnang, Flavio Dell' Acqua, Jessica Faulkner, René C.W. Mandl, Mark H. Johnson, Bonnie Auyeung, Jan K. Buitelaar, Bhismadev Chakrabarti, Michael Brammer, King‘s College London, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Brain and Cognitive Development [Birkbeck College], Birkbeck College [University of London], University of Edinburgh, University of Cambridge [UK] (CAM), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), University Medical Center [Utrecht], Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim], Universität Heidelberg [Heidelberg] = Heidelberg University, Radboud University Medical Center [Nijmegen], Karolinska Institutet [Stockholm], Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), University of Reading (UOR), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], University of London [London], Uppsala University, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Toronto, University of Cyprus [Nicosia] (UCY), Heidelberg University, Janssen Research & Development, University of Messina, Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], This work was supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions and from Autism Speaks., European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), Loth, Eva [0000-0001-9458-9167], Charman, Tony [0000-0003-1993-6549], Tillmann, Julian [0000-0001-9574-9855], Jones, Emily JH [0000-0001-5747-9540], Ahmad, Jumana [0000-0001-5271-0731], Brogna, Claudia [0000-0002-9526-6367], Banaschewski, Tobias [0000-0003-4595-1144], Baron-Cohen, Simon [0000-0001-9217-2544], Crawley, Daisy [0000-0001-9901-1110], Dumas, Guillaume [0000-0002-2253-1844], Hayward, Hannah [0000-0001-5552-2146], Hipp, Joerg [0000-0002-7875-2988], Johnson, Mark [0000-0003-4229-2585], Isaksson, Johan [0000-0003-1033-2618], Lai, Meng-Chuan [0000-0002-9593-5508], Lythgoe, David J [0000-0002-5078-9025], Moessnang, Carolin [0000-0003-4357-2706], Ruigrok, Amber [0000-0001-7711-8056], Ruggeri, Barbara [0000-0002-6231-8829], Simonoff, Emily [0000-0002-5450-0823], Toro, Roberto [0000-0002-6671-858X], Williams, Steve CR [0000-0003-4299-1941], Murphy, Declan GM [0000-0002-6664-7451], Apollo - University of Cambridge Repository, Universität Heidelberg [Heidelberg], Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, University of Cyprus [Nicosia], Radboud university [Nijmegen], Autism Research Centre and Section of Developmental Psychiatry, University of Cambridge [UK] ( CAM ), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM ), Medizinische Fakultät Mannheim, University of Zürich [Zürich] ( UZH ), Génétique humaine et Fonctions cognitives - Human Genetics and Cognitive Functions, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), University of Reading ( UOR ), Goethe-University Frankfurt am Main, Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Roche Pharma Research and Early Development [Basel] ( pRED ), Icahn School of Medicine at Mount Sinai [New York], and European Project : 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS ( 2012 )
Subjects: Male, cognition, Autism Spectrum Disorder, [ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV]Life Sciences [q-bio], Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Individuality, lcsh:RC346-429, Developmental psychology, psyc, 0302 clinical medicine, Cognition, Intellectual disability, molecular biology, genetics, Longitudinal Studies, EEG, Biomarkers, eye-tracking, MRI, neuroimaging, developmental neuroscience, developmental biology, psychiatry and mental health, Precision Medicine, Child, Eye Movement Measurements, Psychiatry, 05 social sciences, 220 Statistical Imaging Neuroscience, Brain, Magnetic Resonance Imaging, 3. Good health, Psychiatry and Mental health, Phenotype, Autism spectrum disorder, Cohort, Female, Psychology, 050104 developmental & child psychology, Clinical psychology, Adult, BF, Neuroimaging, eye tracking, Biomarkers, cognition, EEG, eye-tracking, genetics, MRI, neuroimaging, molecular biology, developmental neuroscience, developmental biology, psychiatry and mental health, Psykiatri, 150 000 MR Techniques in Brain Function, [ SHS.PSY ] Humanities and Social Sciences/Psychology, 03 medical and health sciences, Genetic Heterogeneity, Developmental Neuroscience, mental disorders, medicine, Journal Article, Genetics, Humans, 0501 psychology and cognitive sciences, Saliva, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Genetic heterogeneity, Research, Siblings, Patient Selection, biomarkers, medicine.disease, Precision medicine, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Autism, Observational study, Eye-tracking, [ SDV.GEN ] Life Sciences [q-bio]/Genetics, Neurocognitive, 030217 neurology & neurosurgery, Developmental Biology, Hair
Abstract: Background The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD. Methods LEAP includes 437 children and adults with ASD and 300 individuals with typical development or mild intellectual disability. Using an accelerated longitudinal design, each participant is comprehensively characterised in terms of clinical symptoms, comorbidities, functional outcomes, neurocognitive profile, brain structure and function, biochemical markers and genomics. In addition, 51 twin-pairs (of which 36 had one sibling with ASD) are included to identify genetic and environmental factors in phenotypic variability. Results Here, we describe the demographic characteristics of the cohort, planned analytic stratification approaches, criteria and steps to validate candidate stratification markers, pre-registration procedures to increase transparency, standardisation and data robustness across all analyses, and share some ‘lessons learnt’. A clinical characterisation of the cohort is given in the companion paper (Charman et al., accepted). Conclusion We expect that LEAP will enable us to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities, identify biologically and clinically meaningful ASD subgroups, and help us map phenotypic heterogeneity to different aetiologies. Electronic supplementary material The online version of this article (doi:10.1186/s13229-017-0146-8) contains supplementary material, which is available to authorized users.
Published: 2017
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4. Impact of Mitral Regurgitation Recurrence on Mitral Valve Repair for Secondary Ischemic Mitral Regurgitation

Author: Antonio Salsano, Antonio Nenna, Nicolas Molinari, Sanjeet Singh Avtaar Singh, Cristiano Spadaccio, Francesco Santini, Massimo Chello, Antonio Fiore, Francesco Nappi, Università degli studi di Genova = University of Genoa (UniGe), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Médecine de précision par intégration de données et inférence causale (PREMEDICAL), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Royal Infirmary of Edinburgh, Mayo Clinic [Rochester], Hôpital Henri Mondor, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), and Centre cardiologique du Nord (CCN)
Subjects: left ventricular remodeling, mitral valve repair, [SDV]Life Sciences [q-bio], Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, secondary mitral regurgitation, papillary muscle, ischemic heart disease
Abstract: International audience; Objectives. The current guidelines still do not include specific recommendations on the use of subvalvular repair (SV-r) for treatment of ischemic mitral regurgitation (IMR). Therefore, the objective of our study was to evaluate the clinical impact of mitral regurgitation (MR) recurrence and ventricular remodeling on long-term outcomes after SV-r combined with restrictive annuloplasty (RA-r). Methods. We performed a subanalysis of the papillary muscle approximation trial, studying 96 patients with severe IMR and coronary artery disease undergoing restrictive annuloplasty alongside subvalvular repair (SV-r + RA-r group) or restrictive annuloplasty alone (RA-r group). We analyzed treatment failure differences, the influence of residual MR, left ventricular remodeling, and clinical outcomes. The primary endpoint was treatment failure (composite of death; reoperation; or recurrence of moderate, moderate-to-severe, or severe MR) within 5 years of follow-up after the procedure. Results. A total of 45 patients showed failure of the treatment within 5 years, of which 16 patients underwent SV-r + RA-r (35.6%) and 29 underwent RA-r (64.4%, p = 0.006). Patients with significant residual MR presented with a higher rate of all-cause mortality at 5 years compared with trivial MR (HR 9.09, 95% CI 2.08–33.33, p = 0.003). MR progression occurred earlier in the RA-r group, as 20 patients in the RA-r group vs. 6 in SV-r + RA-r group had a significant MR 2 years after surgery (p = 0.002). Conclusions. RA-r remains a surgical mitral repair technique with an increased risk of failure and mortality at 5 years compared with SV-r. The rates of recurrent MR are higher, and recurrence occurs earlier, with RA-r alone compared to SV-r. The addition of the subvalvular repair increases the durability of the repair, thus extending all of the benefits of preventing MR recurrence.
Published: 2023
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5. Screening for asymptomatic carotid stenosis in patients with non-valvular atrial fibrillation

Author: Kosmas I. Paraskevas, Hans-Henning Eckstein, Armando Mansilha, Jean-Baptiste Ricco, George Geroulakos, Vincenzo Di Lazzaro, Tatjana Rundek, Gaetano Lanza, Gustav Fraedrich, Alexei S. Svetlikov, Jasjit S. Suri, Clark J. Zeebregts, Alun H. Davies, Laura Capoccia, Robert M. Proczka, Piotr Myrcha, Pier Luigi Antignani, Jose Fernandes e Fernandes, J. David Spence, Alan Dardik, Mateja K. Jezovnik, Michael Knoflach, George S. Lavenson, Stavros K. Kakkos, Arkadiusz Jawien, Mauro Silvestrini, Aleš Blinc, Francesco Spinelli, Francesco Stilo, Piotr Musiałek, Sherif Sultan, Guillaume Goudot, Christos D. Liapis, Luca Saba, Gianluca Faggioli, Rodolfo Pini, Pavel Poredos, Dimitri P. Mikhailidis, Peter Gloviczki, Andrew N. Nicolaides, Man, Biomaterials and Microbes (MBM), Repositório da Universidade de Lisboa, Goudot, Guillaume, Central Clinic of Athens SA [Athens, Greece] (2CA), Klinikums rechts der Isar, Universidade do Porto = University of Porto, Centre hospitalier universitaire de Poitiers (CHU Poitiers), University General Hospital ' Attikon ' [Athens, Greece], National and Kapodistrian University of Athens (NKUA), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), University of Miami, IRCSS MultiMedica Hospital [Castellanza, Italy] (2MH), Leopold Franzens Universität Innsbruck - University of Innsbruck, North-Western Scientific Clinical Center of Federal Medical Biological Agency [St. Petersburg, Russia] (NWS2CFMBA), Stroke Diagnosis and Monitoring Division [Roseville, CA, USA] (DMD/AtheroPointTM), University Medical Center Groningen [Groningen] (UMCG), Imperial College London, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Medicover Hospital [Warsaw, Poland] (MH), Medical University of Warsaw - Poland, Nuova Villa Claudia [Rome, Italy] (NVC), Universidade de Lisboa = University of Lisbon (ULISBOA), Robarts Research Institute [Canada], University of Western Ontario (UWO), Department of Neuroscience, Yale University School of Medicine, Yale School of Medicine [New Haven, Connecticut] (YSM), University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), Uniformed Services University of the Health Sciences (USUHS), General University Hospital of Patras, Nicolaus Copernicus University [Toruń], Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia], University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University Hospital Galway, Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Athens Vascular Research Center [Athens, Greece] (AVRC), Università degli Studi di Cagliari = University of Cagliari (UniCa), Alma Mater Studiorum University of Bologna (UNIBO), University College of London [London] (UCL), Mayo Clinic [Rochester], and University of Nicosia
Subjects: Stroke, [SDV] Life Sciences [q-bio], Ischemic Attack, Transient, [SDV]Life Sciences [q-bio], Atrial Fibrillation, Humans, Carotid Stenosis, Cardiology and Cardiovascular Medicine
Abstract: © 2022 Elsevier B.V. All rights reserved., Jolobe supports that screening for asymptomatic carotid stenosis (AsxCS) should be extended to patients with non-valvular atrial fibrillation (NVAF). Indeed, a 2021 meta-analysis (n = 20 studies; 49,070 patients) demonstrated that the pooled prevalence of >50% AsxCS inpatients with NVAF was 12.4% (range: 4.4–24.3%). Although this issue was not discussed in our manuscript, the optimal management of patients presenting with a recent transient ischemic attack [TIA]/ischemic stroke with an ipsilateral 50–99% carotid stenosis and concomitant NVAF was addressed by the 2023 European Society for Vascular Surgery (ESVS) carotid guidelines. It was recognized that although no guidelines have provided recommendations regarding the management of these patients, a pragmatic approach is warranted.
Published: 2023
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6. Why do guidelines recommend screening for abdominal aortic aneurysms, but not for asymptomatic carotid stenosis? A plea for a randomized controlled trial

Author: Kosmas I. Paraskevas, J. David Spence, Dimitri P. Mikhailidis, Pier Luigi Antignani, Peter Gloviczki, Hans-Henning Eckstein, Francesco Spinelli, Francesco Stilo, Luca Saba, Pavel Poredos, Alan Dardik, Christos D. Liapis, Armando Mansilha, Gianluca Faggioli, Rodolfo Pini, Mateja K. Jezovnik, Sherif Sultan, Piotr Musiałek, Guillaume Goudot, George S. Lavenson, Arkadiusz Jawien, Aleš Blinc, Piotr Myrcha, Jose Fernandes e Fernandes, George Geroulakos, Stavros K. Kakkos, Michael Knoflach, Robert M. Proczka, Laura Capoccia, Tatjana Rundek, Alexei S. Svetlikov, Mauro Silvestrini, Jean-Baptiste Ricco, Alun H. Davies, Vincenzo Di Lazzaro, Jasjit S. Suri, Gaetano Lanza, Gustav Fraedrich, Clark J. Zeebregts, Andrew N. Nicolaides, Central Clinic of Athens SA [Athens, Greece] (2CA), Robarts Research Institute [Canada], University of Western Ontario (UWO), Royal Free Hospital [London, UK], University College of London [London] (UCL), Nuova Villa Claudia [Rome, Italy] (NVC), Mayo Clinic [Rochester], Klinikums rechts der Isar, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Università degli Studi di Cagliari = University of Cagliari (UniCa), University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Department of Neuroscience, Yale University School of Medicine, Yale School of Medicine [New Haven, Connecticut] (YSM), Athens Vascular Research Center [Athens, Greece] (AVRC), Universidade do Porto = University of Porto, Hospital de S. João [Porto, Portugal] (HSJ), Alma Mater Studiorum University of Bologna (UNIBO), Policlinico S. Orsola-malpighi, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Servizio sanitario regionale Emilia-Romagna, The University of Texas Health Science Center at Houston (UTHealth), University Hospital Galway, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Uniformed Services University of the Health Sciences (USUHS), Nicolaus Copernicus University [Toruń], Medical University of Warsaw - Poland, Universidade de Lisboa = University of Lisbon (ULISBOA), University General Hospital ' Attikon ' [Athens, Greece], National and Kapodistrian University of Athens (NKUA), General University Hospital of Patras, Leopold Franzens Universität Innsbruck - University of Innsbruck, Medicover Hospital [Warsaw, Poland] (MH), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), University of Miami, North-Western Scientific Clinical Center of Federal Medical Biological Agency [St. Petersburg, Russia] (NWS2CFMBA), Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Imperial College London, Atheropoint LLC Company [Roseville, CA, USA], IRCSS MultiMedica Hospital [Castellanza, Italy] (2MH), University Medical Center Groningen [Groningen] (UMCG), University of Nicosia, Goudot, Guillaume, and Repositório da Universidade de Lisboa
Subjects: Endarterectomy, Carotid, Carotid plaque burden, [SDV]Life Sciences [q-bio], Stroke, Guidelines, [SDV] Life Sciences [q-bio], Asymptomatic carotid atherosclerosis, Risk Factors, Asymptomatic Diseases, Carotid stenosis, Screening, Humans, Mass Screening, Cardiology and Cardiovascular Medicine, Aortic Aneurysm, Abdominal, Randomized Controlled Trials as Topic
Abstract: © 2022 Elsevier B.V. All rights reserved., ackground: Current guidelines do not recommend screening for asymptomatic carotid artery stenosis (AsxCS). The rationale behind this recommendation is that detection of AsxCS may lead to an unnecessary carotid intervention. In contrast, screening for abdominal aortic aneurysms is strongly recommended. Methods: A critical analysis of the literature was performed to evaluate the implications of detecting AsxCS. Results: Patients with AsxCS are at high risk for future stroke, myocardial infarction and vascular death. Population-wide screening for AsxCS should not be recommended. Additionally, screening of high-risk individuals for AsxCS with the purpose of identifying candidates for a carotid intervention is inappropriate. Instead, selective screening for AsxCS should be considered and should be viewed as an opportunity to identify individuals at high risk for atherosclerotic cardiovascular disease and future cardiovascular events for the timely initiation of intensive medical therapy and risk factor modification. Conclusions: Although mass screening should not be recommended, there are several arguments suggesting that selective screening for AsxCS should be considered. The rationale supporting such selective screening is to optimize risk factor control and to initiate intensive medical therapy for prevention of future cardiovascular events, rather than to identify candidates for an intervention.
Published: 2022
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7. Overview of primary adult retroperitoneal tumours

Author: Khoubeyb Abdelhafidh, D Tzanis, Luca Improta, T Bouhadiba, Sylvie Bonvalot, and Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM)
Subjects: Adult, Leiomyosarcoma, medicine.medical_specialty, Extragonadal, Lymphoma, [SDV]Life Sciences [q-bio], Percutaneous biopsy, World health, Metastasis, Paraganglioma, 03 medical and health sciences, Neoplasm Seeding, 0302 clinical medicine, Preoperative Care, Rhabdomyosarcoma, Carcinoma, medicine, Humans, Retroperitoneal space, Retroperitoneal Neoplasms, 030212 general & internal medicine, Pathological, Neoplasm Staging, Leiomyoma, business.industry, Biopsy, Needle, Sarcoma, Liposarcoma, General Medicine, Neoplasms, Germ Cell and Embryonal, Diagnostic strategy, medicine.disease, Tumor Burden, 3. Good health, medicine.anatomical_structure, Oncology, Neurofibrosarcoma, 030220 oncology & carcinogenesis, Surgery, Lymphangioma, Cystic, Radiology, Neoplasm Grading, Tomography, X-Ray Computed, business, Myxoma, Neurilemmoma
Abstract: In front of a primary retroperitoneal tumour, it is necessary to have in mind all possible diagnoses in order to specify the diagnostic strategy and the treatment. According to the World Health Organization (WHO) classification of tumours, mesenchymal benign and malignant tumours (including sarcomas and, currently, neurogenic tumours), parasympathetic tumours, extragonadal germ cell tumours, and lymphoid tumours have been identified. By definition, primary retroperitoneal tumours start independently from the retroperitoneal organs. Secondary lesions, carcinoma metastasis, and adenopathy are excluded from this definition, but they can also develop in the retroperitoneal space and lead to misdiagnoses. In the absence of positive tumour markers or an evocative biology, percutaneous biopsy is necessary. Pathological diagnosis is necessary to decide whether surgery must be done, its timing among the other treatments, and its extension. This paper summarizes all the diagnostic possibilities.
Published: 2020
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8. The burden of carotid-related strokes

Author: Kosmas I. Paraskevas, Dimitri P. Mikhailidis, Hediyeh Baradaran, Reinoud P. H. Bokkers, Alun H. Davies, Hans-Henning Eckstein, Gianluca Faggioli, Jose Fernandes E Fernandes, Mauro Gargiulo, Arkadiusz Jawien, Mateja K. Jezovnik, Stavros K. Kakkos, Michael Knoflach, M. Eline Kooi, Gaetano Lanza, Christos D. Liapis, Ian M. Loftus, Armando Mansilha, Laura Mechtouff, Antoine Millon, Piotr Myrcha, Andrew N. Nicolaides, Rodolfo Pini, Pavel Poredos, Jean-Baptiste Ricco, Tatjana Rundek, Luca Saba, Mauro Silvestrini, Francesco Spinelli, Francesco Stilo, Sherif Sultan, Jasjit S. Suri, Alexei V. Svetlikov, Tissa Wijeratne, Clark J. Zeebregts, Peter Gloviczki, Paraskevas, Kosmas I, Mikhailidis, Dimitri P, Baradaran, Hediyeh, Bokkers, Reinoud P H, Davies, Alun H, Eckstein, Hans-Henning, Faggioli, Gianluca, Fernandes E Fernandes, Jose, Gargiulo, Mauro, Jawien, Arkadiusz, Jezovnik, Mateja K, Kakkos, Stavros K, Knoflach, Michael, Kooi, M Eline, Lanza, Gaetano, Liapis, Christos D, Loftus, Ian M, Mansilha, Armando, Mechtouff, Laura, Millon, Antoine, Myrcha, Piotr, Nicolaides, Andrew N, Pini, Rodolfo, Poredos, Pavel, Ricco, Jean-Baptiste, Rundek, Tatjana, Saba, Luca, Silvestrini, Mauro, Spinelli, Francesco, Stilo, Francesco, Sultan, Sherif, Suri, Jasjit S, Svetlikov, Alexei V, Wijeratne, Tissa, Zeebregts, Clark J, Gloviczki, Peter, Beeldvorming, MUMC+: DA BV Klinisch Fysicus (9), RS: Carim - B06 Imaging, CarMeN, laboratoire, Central Clinic of Athens SA [Athens, Greece] (2CA), University College of London [London] (UCL), University of Utah, University Medical Center Groningen [Groningen] (UMCG), Imperial College Healthcare NHS Trust [London, UK] (ICH), Technische Universität München = Technical University of Munich (TUM), University of Bologna/Università di Bologna, Universidade de Lisboa = University of Lisbon (ULISBOA), Nicolaus Copernicus University [Toruń], The University of Texas Health Science Center at Houston (UTHealth), University of Patras, School of Medicine, Leopold Franzens Universität Innsbruck - University of Innsbruck, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University [Maastricht], Maastricht University Medical Centre (MUMC), Karlsruher Institut für Technologie (KIT), IRCSS MultiMedica Hospital [Castellanza, Italy] (2MH), Athens Vascular Research Center [Athens, Greece] (AVRC), St George's, University of London, Universidade do Porto = University of Porto, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hospices Civils de Lyon (HCL), Hôpital Louis Pradel [CHU - HCL], Université de Lyon, University of Warsaw (UW), University of Nicosia, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Centre hospitalier universitaire de Poitiers (CHU Poitiers), University of Miami, Università degli Studi di Cagliari = University of Cagliari (UniCa), Università Politecnica delle Marche [Ancona] (UNIVPM), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), University Hospital Galway, National University of Ireland [Galway] (NUI Galway), Stroke Diagnosis and Monitoring Division [Roseville, CA, USA] (DMD/AtheroPointTM), NRC Institute of immunology FMBA, Moscow Russian federation, Melbourne Medical School [Melbourne], Faculty of Medicine, Dentistry and Health Sciences [Melbourne], University of Melbourne-University of Melbourne, Mayo Clinic [Rochester], Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Man, Biomaterials and Microbes (MBM), and University of Groningen
Subjects: [SDV] Life Sciences [q-bio], endovascular aneurysm repair (EVAR), for abdominal aortic aneurysms (AAA), infrarenal neck, an uncomplicated and sustainable outcome, hostile aortic neck criteria, [SDV]Life Sciences [q-bio], General Medicine, Letter to the Editor
Abstract: After 3 decades of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA), the infrarenal neck is considered the most important determining factor for an uncomplicated and sustainable outcome. As the envelope has been pushed toward treating more challenging infrarenal necks with standard endografts, there are numerous publications regarding hostile aortic neck criteria.1–4 During preoperative planning and sizing, aortic neck length, diameter, suprarenal and infrarenal angulation, shape, and occurrence of calcium and thrombus are measured by most endovascular specialists, using dedicated software. Moreover, all endograft manufacturers have defined specific instructions for use (IFU) concerning infrarenal neck characteristics. Infrarenal neck length seems to be one of the most important criteria to consider, with a minimum of 10 or 15 mm, according to the IFU of most commercially available ndografts.3 According to most CoreLab definitions, the infrarenal neck ends when the aortic diameter increases >10% compared with baseline (ie, the diameter just below the lower margin of the lowest renal artery).5,6 Although the determination of the pre-EVAR neck characteristics gives the treating physicians a handle in the sizing and planning process, it does not always match with the actual circumferential seal of the endograft in the aortic neck after deployment. Oversizing the endograft’s main body often extends the seal compared with the predefined aortic neck length. However, especially in hostile necks, this does not always have the anticipated and desired effect.7 It seems reasonable to assume that the post-EVAR achieved circumferential apposition between the endograft and the aortic wall is a better indicator for outcome than the pre-EVAR determined aortic neck characteristics alone. The so-called sealing zone in the infrarenal aortic neck has received less attention in EVAR literature so far. A possible explanation for this might be that it is harder to define than the well-known aortic neck criteria. It also depends on the positioning of the endograft during the procedure. Moreover, the circumferential apposition between the endograft and the aortic wall has to be determined on the post- EVAR computed tomography (CT) scan, which is not a standard measurement so far.8 A Delphi method is often used to orchestrate expert opinions systematically when evidence is scarce or lacking, and research questions cannot simply be studied with experimental and epidemiological methods.9 In this study, the Delphi method is used to propose a consensus definition of the infrarenal sealing zone. Furthermore, it provides an algorithm to determine when and if adjunctive procedure(s) or reintervention should be considered in case of potential proximal sealing failure of the endograft.
Published: 2022
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9. Exploring ultracold collisions in $^6$Li-$^{53}$Cr Fermi mixtures: Feshbach resonances and scattering properties of a novel alkali-transition metal system

Author: Ciamei, A., Finelli, S., Trenkwalder, A., Inguscio, M., Simoni, A., Zaccanti, M., Università degli Studi di Firenze = University of Florence (UniFI), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), H2020 Marie Skłodowska-Curie Actions, MSCA: 894442, European Research Council, ERC: 637738, Ministero dell’Istruzione, dell’Università e della Ricerca, MIUR, Horizon 2020, and Foundation for Alcohol Research and Education, FARE
Subjects: Seismic waves, Fermionic atoms, Atomic Physics (physics.atom-ph), Scattering property, FOS: Physical sciences, S-waves, Property predictions, Resonance, Physics - Atomic Physics, Cold and ultra-cold collisions, Ultracold collisions, Physics::Atomic Physics, Quantum dynamics, Transition metal system, [PHYS]Physics [physics], Condensed Matter::Quantum Gases, Coupled-channel models, Chromium alloys, Lithium alloys, Transition metals, Binary alloys, Yield prediction, Quantum Gases (cond-mat.quant-gas), Mixtures, Atomic and molecular collisions, P waves, Condensed Matter - Quantum Gases, Molecular physics, Feshbach resonances
Abstract: We investigate ultracold collisions in a novel mixture of $^6$Li and $^{53}$Cr fermionic atoms, discovering more than 50 interspecies Feshbach resonances via loss spectroscopy. Building a full coupled-channel model, we unambiguously characterize the $^{6}$Li-$^{53}$Cr scattering properties and yield predictions for other isotopic pairs. In particular, we identify various Feshbach resonances that enable the controlled tuning of elastic $s$- and $p$-wave $^{6}$Li-$^{53}$Cr interactions. Our studies thus make lithium-chromium mixtures emerge as optimally-suited platforms for the experimental search of elusive few- and many-body regimes of highly-correlated fermionic matter, and for the realization of a new class of ultracold polar molecules possessing both electric and magnetic dipole moments., Comment: 12 pages, 4 figures, 4 tables
Published: 2022
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10. Stratifying the autistic phenotype using electrophysiological indices of social perception

Author: Luke Mason, Carolin Moessnang, Christopher Chatham, Lindsay Ham, Julian Tillmann, Guillaume Dumas, Claire Ellis, Claire S. Leblond, Freddy Cliquet, Thomas Bourgeron, Christian Beckmann, Tony Charman, Beth Oakley, Tobias Banaschewski, Andreas Meyer-Lindenberg, Simon Baron-Cohen, Sven Bölte, Jan K. Buitelaar, Sarah Durston, Eva Loth, Bob Oranje, Antonio Persico, Flavio Dell’Acqua, Christine Ecker, Mark H. Johnson, Declan Murphy, Emily J. H. Jones, University of London [London], Universität Heidelberg [Heidelberg] = Heidelberg University, F. Hoffmann-La Roche [Basel], King‘s College London, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], Radboud University Medical Center [Nijmegen], Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], Heidelberg University, University of Cambridge [UK] (CAM), Stockholm Health Care Services (SLSO), University Medical Center [Utrecht], Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Roche Pharma Research and Early Development [Basel] (pRED), This project has received funding from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies’ in kind contribution (E.J.H.J., M.J., T.C., and D.M.), and the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. 777394 (E.J.H.J., M.J., T.C., and D.M.). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA and AUTISM SPEAKS, Autistica, SFARI, awards from the Medical Research Council (MR/K021389/1, MR/T003057/1, E.J.H.J., M.J., and T.C.)., European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), and European Project: 777394,H2020-JTI-IMI2-2016-10-two-stage,AIMS-2-TRIALS(2018)
Subjects: Evoked Potentials, Humans, Phenotype, Social Perception, Autism Spectrum Disorder, Autistic Disorder, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], [SCCO.NEUR]Cognitive science/Neuroscience, fMRI, 220 Statistical Imaging Neuroscience, autism, General Medicine, 130 000 Cognitive Neurology & Memory, polygenic score, N170 latence
Abstract: Contains fulltext : 282637.pdf (Publisher’s version ) (Closed access) Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication, but also great heterogeneity. To offer individualized medicine approaches, we need to better target interventions by stratifying autistic people into subgroups with different biological profiles and/or prognoses. We sought to validate neural responses to faces as a potential stratification factor in ASD by measuring neural (electroencephalography) responses to faces (critical in social interaction) in N = 436 children and adults with and without ASD. The speed of early-stage face processing (N170 latency) was on average slower in ASD than in age-matched controls. In addition, N170 latency was associated with responses to faces in the fusiform gyrus, measured with functional magnetic resonance imaging, and polygenic scores for ASD. Within the ASD group, N170 latency predicted change in adaptive socialization skills over an 18-month follow-up period; data-driven clustering identified a subgroup with slower brain responses and poor social prognosis. Use of a distributional data-driven cutoff was associated with predicted improvements of power in simulated clinical trials targeting social functioning. Together, the data provide converging evidence for the utility of the N170 as a stratification factor to identify biologically and prognostically defined subgroups in ASD.
Published: 2022
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11. Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

Author: J. M., Fu, Satterstrom, F. K., Peng, M., Brand, H., Collins, R. L., Dong, S., Wamsley, B., Klei, L., Wang, L., Hao, S. P., Stevens, C. R., Cusick, C., Babadi, M., Banks, E., Collins, B., Dodge, S., Gabriel, S. B., Gauthier, L., Lee, S. K., Liang, L., Ljungdahl, A., Mahjani, B., Sloofman, L., Smirnov, A. N., Barbosa, M., Betancur, C., Brusco, A., Chung, B. H. Y., Cook, E. H., Cuccaro, M. L., Domenici, E., Ferrero, G. B., Gargus, J. J., Herman, G. E., Hertz-Picciotto, I., Maciel, P., Manoach, D. S., Passos-Bueno, M. R., Persico, A., Renieri, A., Sutcliffe, J. S., Tassone, F., Trabetti, E., Campos, G., Cardaropoli, S., Carli, D., Chan, M. C. Y., Fallerini, C., Giorgio, E., Girardi, A. C., Hansen-Kiss, E., Lee, S. L., Lintas, C., Ludena, Y., Nguyen, R., Pavinato, L., Pericak-Vance, M., Pessah, I. N., Schmidt, R. J., Smith, M., Costa, C. I. S., Trajkova, S., Wang, J. Y. T., M. H. C., Yu, Aleksic, B., Artomov, M., Benetti, E., Biscaldi-Schafer, M., Borglum, A. D., Carracedo, A., Chiocchetti, A. G., Coon, H., Doan, R. N., Fernandez-Prieto, M., Freitag, C. M., Gerges, S., Guter, S., Hougaard, D. M., Hultman, C. M., Jacob, S., Kaartinen, M., Kolevzon, A., Kushima, I., Lehtimaki, T., Rizzo, C. L., Maltman, N., Manara, M., Meiri, G., Menashe, I., Miller, J., Minshew, N., Mosconi, M., Ozaki, N., Palotie, A., Parellada, M., Puura, K., Reichenberg, A., Sandin, S., Scherer, S. W., Schlitt, S., Schmitt, L., Schneider-Momm, K., Siper, P. M., Suren, P., Sweeney, J. A., Teufel, K., del Pilar Trelles, M., Weiss, L. A., Yuen, R., Cutler, D. J., De Rubeis, S., Buxbaum, J. D., Daly, M. J., Devlin, B., Roeder, K., Sanders, S. J., Talkowski, M. E., Massachusetts General Hospital [Boston], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Carnegie Mellon University [Pittsburgh] (CMU), Harvard Medical School [Boston] (HMS), University of California [San Francisco] (UC San Francisco), University of California (UC), University of California [Los Angeles] (UCLA), University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Torino = University of Turin (UNITO), Azienda Ospedalerio - Universitaria Città della Salute e della Scienza di Torino = University Hospital Città della Salute e della Scienza di Torino, The University of Hong Kong (HKU), University of Illinois [Chicago] (UIC), University of Illinois System, University of Miami Leonard M. Miller School of Medicine (UMMSM), University of Trento [Trento], University of California [Irvine] (UC Irvine), Nationwide Children's Hospital, University of California [Davis] (UC Davis), Universidade do Minho = University of Minho [Braga], Massachusetts General Hospital [Boston, MA, USA], Escola Politecnica da Universidade de Sao Paulo [Sao Paulo], Università degli Studi di Messina = University of Messina (UniMe), Università degli Studi di Siena = University of Siena (UNISI), Azienda Ospedaliera Universitaria Senese, Vanderbilt University [Nashville], Vanderbilt University School of Medicine [Nashville], Università degli studi di Verona = University of Verona (UNIVR), University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Emory University School of Medicine, Emory University [Atlanta, GA], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Autism Sequencing Consortium (ASC), Broad Institute Center for Common Disease Genomics (Broad-CCDG), iPSYCH-BROAD Consortium : Branko Aleksic, Mykyta Artomov, Elisa Benetti, Monica Biscaldi-Schafer, Anders D Børglum, Angel Carracedo, Andreas G Chiocchetti, Hilary Coon, Ryan N Doan, Montserrat Fernández-Prieto, Christine M Freitag, Sherif Gerges, Stephen Guter, David M Hougaard, Christina M Hultman, Suma Jacob, Miia Kaartinen, Alexander Kolevzon, Itaru Kushima, Terho Lehtimäki, Caterina Lo Rizzo, Nell Maltman, Marianna Manara, Gal Meiri, Idan Menashe, Judith Miller, Nancy Minshew, Matthew Mosconi, Norio Ozaki, Aarno Palotie, Mara Parellada, Kaija Puura, Abraham Reichenberg, Sven Sandin, Stephen W Scherer, Sabine Schlitt, Lauren Schmitt, Katja Schneider-Momm, Paige M Siper, Pål Suren, John A Sweeney, Karoline Teufel, Maria Del Pilar Trelles, Lauren A Weiss, Ryan Yuen., and Betancur, Catalina
Subjects: Broad Institute Center for Common Disease Genomics, Autism Sequencing Consortium, DNA Copy Number Variations, Autism Spectrum Disorder, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Autism, Intellectual and Developmental Disabilities (IDD), iPSYCH-BROAD Consortium, autism spectrum disorders, disease gene, copy number variants, neuropsychiatric disorders, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, GENOMAS, Medical and Health Sciences, Article, Clinical Research, Genetics, Humans, 2.1 Biological and endogenous factors, Genetic Predisposition to Disease, Autistic Disorder, Aetiology, Genetic association study, Pediatric, Human Genome, Neurodevelopmental disorders, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Biological Sciences, Autism spectrum disorders, Brain Disorders, Mental Health, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Mutation, Gene expression, Biotechnology, Developmental Biology
Abstract: International audience; Some individuals with autism spectrum disorder (ASD) carry functional mutations rarely observed in the general population. We explored the genes disrupted by these variants from joint analysis of protein-truncating variants (PTVs), missense variants and copy number variants (CNVs) in a cohort of 63,237 individuals. We discovered 72 genes associated with ASD at false discovery rate (FDR) ≤ 0.001 (185 at FDR ≤ 0.05). De novo PTVs, damaging missense variants and CNVs represented 57.5%, 21.1% and 8.44% of association evidence, while CNVs conferred greatest relative risk. Meta-analysis with cohorts ascertained for developmental delay (DD) (n = 91,605) yielded 373 genes associated with ASD/DD at FDR ≤ 0.001 (664 at FDR ≤ 0.05), some of which differed in relative frequency of mutation between ASD and DD cohorts. The DD-associated genes were enriched in transcriptomes of progenitor and immature neuronal cells, whereas genes showing stronger evidence in ASD were more enriched in maturing neurons and overlapped with schizophrenia-associated genes, emphasizing that these neuropsychiatric disorders may share common pathways to risk.
Published: 2022
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12. In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification

Author: Grazia Cottone, Letizia Chiodo, Luca Maragliano, Michel-Robert Popoff, Christine Rasetti-Escargueil, Emmanuel Lemichez, Thérèse E. Malliavin, Department of Physics and Chemistry, Università degli studi di Palermo - University of Palermo, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Dpt of Neuroscience and Brain Technologies [Genova], NeuroEngineering & bio-arTificial Synergic SystemS Laboratory [Genova] (NetS3 Lab), Istituto Italiano di Tecnologia (IIT)-Istituto Italiano di Tecnologia (IIT), Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia], Toxines bactériennes - Bacterial Toxins, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique et Chimie Théoriques (LPCT), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the French National Research Agency grant ANR-20-SEBM-0003 as well as the grant X-BAT ANR 20 SEBM 0003 to E.L. This research was also funded by GENCI (project A0100710764), CINECA under the ISCRA initiative (IsB19 BONTDYN, IsC78 MoDyBoB1) and PRACE under DECI initiative (DECI-16 DyMoBoNT, at the Irish Centre for High-End Computing-ICHEC) for supercomputing time. TM, CRE, and EL acknowledge CNRS, INSERM, and Institut Pasteur for financial support. LC acknowledges the support of the International Center for Relativistic Astrophysics Network (ICRANet) and of the Italian National Group for Mathematical Physics (GNFM-INdAM). GC acknowledges the University of Palermo (grant FFR-D08Cottone)., ANR-20-SEBM-0003,X-BAT,Recherche et production d'un antitoxin décavalent équin contre les attaques délibérées de neurotoxines botuliques(2020), Cottone G., Chiodo L., Maragliano L., Popoff M.-R., Rasetti-Escargueil C., Lemichez E., Malliavin T.E., Malliavin, Therese, and Recherche et production d'un antitoxin décavalent équin contre les attaques délibérées de neurotoxines botuliques - - X-BAT2020 - ANR-20-SEBM-0003 - SEBM - VALID
Subjects: Clostridium botulinum, botulinum toxin, molecular dynamics, residue protonation, homology modeling, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Health, Toxicology and Mutagenesis, molecular dynamic, [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Hydrogen-Ion Concentration, Toxicology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Gangliosides, Solvents, Botulinum Toxins, Type A, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]
Abstract: International audience; Although botulinum neurotoxins (BoNTs) are among the most toxic compounds found in nature, their molecular mechanism of action is far from being elucidated. A key event is the conformational transition due to acidification of the interior of synaptic vesicles, leading to translocation of the BoNT catalytic domain into the neuronal cytosol. To investigate these conformational variations, homology modeling and atomistic simulations are combined to explore the internal dynamics of the sub-types BoNT/A1 (the most-used sub-type in medical applications) and BoNT/E1 (the most kinetically efficient sub-type). This first simulation study of di-chain BoNTs in closed and open states considers the effects of both neutral and acidic pH. The conformational mobility is driven by domain displacements of the ganglioside-binding site in the receptor binding domain, the translocation domain (HCNT) switch, and the belt α-helix, which present multiple conformations, depending on the primary sequence and the pH. Fluctuations of the belt α-helix are observed for closed conformations of the toxins and at acidic pH, while patches of more solvent-accessible residues appear under the same conditions in the core translocation domain HCNT. These findings suggest that, during translocation, the higher mobility of the belt could be transmitted to HCNT, leading to the favorable interaction of HCNT residues with the non-polar membrane environment.
Published: 2022
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13. A novel extrusion-based 3D bioprinting system for skeletal muscle tissue engineering

Author: E Fornetti, F De Paolis, C Fuoco, S Bernardini, S M Giannitelli, A Rainer, D Seliktar, F Magdinier, J Baldi, R Biagini, S Cannata, S Testa, C Gargioli, Università degli Studi di Roma Tor Vergata [Roma], Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and PRIN 2017: 201742SBXA_004 founded by Italian Ministry of University and Research to Cesare Gargioli.
Subjects: Biomaterials, 3D bioprinting, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Settore BIO/13, Biomedical Engineering, VML, muscle reconstruction, Bioengineering, PEG-fibrinogen, General Medicine, skeletal muscle tissue engineering, Biochemistry, Biotechnology
Abstract: Three-dimensional (3D) bioprinting is an emerging technology, which turned out to be an optimal tool for tissue engineering approaches. To date, different printing systems have been developed. Among them, the extrusion-based approach demonstrated to be the most suitable for skeletal muscle tissue engineering, due to its ability to produce and deposit printing fibers in a parallel pattern that well mimic the native skeletal muscle tissue architecture. In tissue bioengineering, a key role is played by biomaterials, which must possess the key requisite of ‘printability’. Nevertheless, this feature is not often well correlated with cell requirements, such as motives for cellular adhesion and/or absorbability. To overcome this hurdle, several efforts have been made to obtain an effective bioink by combining two different biomaterials in order to reach a good printability besides a suitable biological activity. However, despite being efficient, this strategy reveals several outcomes limitations. We report here the development and characterization of a novel extrusion-based 3D bioprinting system, and its application for correction of volumetric muscle loss (VML) injury in a mouse model. The developed bioprinting system is based on the use of PEG-Fibrinogen, a unique biomaterial with excellent biocompatibility, well-suited for skeletal muscle tissue engineering. With this approach, we obtained highly organized 3D constructs, in which murine muscle progenitors were able to differentiate into muscle fibers arranged in aligned bundles and capable of spontaneously contracting when cultured in vitro. Furthermore, to evaluate the potential of the developed system in future regenerative medicine applications, bioprinted constructs laden with either murine or human muscle progenitors were transplanted to regenerate the Tibialis Anterior muscle of a VML murine model, one month after grafting.
Published: 2023
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14. Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry

Author: Meng-Chuan Lai, Elena Maria Busuoli, Antonio M. Persico, Bonnie Auyeung, Eva Loth, Sarah Durston, Andreas Meyer-Lindenberg, Sven Bölte, Carolin Moessnang, Stavros Trakoshis, Marianne Oldehinkel, Prantik Kundu, Steve C.R. Williams, Jan K. Buitelaar, Sarah Baumeister, Tony Charman, Michael V. Lombardo, Isotta Landi, Richard A. I. Bethlehem, Rosemary Holt, Veronica Mandelli, Christine Ecker, Natasha Bertelsen, Julian Tillmann, Declan G. Murphy, Christian F. Beckmann, Jakob Seidlitz, Eleonora Satta, Mark H. Johnson, Will Spooren, Simon Baron-Cohen, Guillaume Dumas, Luke Mason, Emily J.H. Jones, Thomas Bourgeron, Istituto Italiano di Tecnologia (IIT), University of Trento [Trento], University of Cambridge [UK] (CAM), Children’s Hospital of Philadelphia (CHOP ), University of Pennsylvania, University of Cyprus [Nicosia] (UCY), University of Edinburgh, King‘s College London, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Universität Heidelberg [Heidelberg] = Heidelberg University, Radboud University Medical Center [Nijmegen], Karolinska Institutet [Stockholm], Stockholm Health Care Services (SLSO), Curtin University [Perth], Planning and Transport Research Centre (PATREC), University Medical Center [Utrecht], Goethe-Universität Frankfurt am Main, University of London [London], Monash University [Melbourne], University of Messina, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), University of Vienna [Vienna], Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], Centre for Addiction and Mental Health [Toronto] (CAMH), The Hospital for sick children [Toronto] (SickKids), University of Toronto, National Taiwan University [Taiwan] (NTU), This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 755816 (ERC Starting Grant to MVL). This work was also supported by EU-AIMS and EU AIMS-2-TRIALS, which both received support from the Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115300 and the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement No. 777394, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (Grant No. FP7/2007–2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions, and from Autism Speaks, Autistica and the Simons Foundation for Autism Research Initiative. The views expressed are those of the author(s) and not necessarily those of the IMI 2JU. This work was also supported by the Netherlands Organization for Scientific Research through Vidi grants (Grant No. 864.12.003 [to CFB]), from the FP7 (Grant Nos. 602805) (AGGRESSOTYPE) (to JKB), 603016 (MATRICS), and 278948 (TACTICS), and from the European Community’s Horizon 2020 Programme (H2020/2014–2020) (Grant Nos. 643051 [MiND] and 642996 (BRAINVIEW). This work received funding from the Wellcome Trust UK Strategic Award (Award No. 098369/Z/12/Z) and from the National Institute for Health Research Maudsley Biomedical Research Centre (to DGMM). M-CL was supported by the Academic Scholars Award from the Department of Psychiatry, University of Toronto, the Slaight Family Child and Youth Mental Health Innovation Fund from the CAMH Foundation, the Ontario Brain Institute via the Province of Ontario Neurodevelopmental Disorders (POND) Network (IDS-I l-02), the Canadian Institutes of Health Research Sex and Gender Science Chair (GSB 171373), and the Innovation Fund of the Alternative Funding Plan for the Academic Health Sciences Centres of Ontario (CAM-20-004). R.A.I.B acknowledges research support by the Autism Research Trust and a British Academy Fellowship (PF2\180017). MHJ, TC, and EJHJ acknowledge support from a UK MRC Programme Grant., the EU-AIMS LEAP group : Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian F. Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Jan K. Buitelaar, Bhismadev Chakrabarti, Tony Charman, Chris Chatham, Ineke Cornelissen, Daisy Crawley, Flavio Dell’Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary J. Holt, Mark H. Johnson, Emily J. H. Jones, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D’ardhuy, Michael V. Lombardo, Eva Loth, David J. Lythgoe, René Mandl, Andre Marquand, Luke Mason, Maarten Mennes, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Declan G. M. Murphy, Bethany Oakley, Laurence O’Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M. Persico, Barbara Ruggeri, Amber N. V. Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Will Spooren, Julian Tillmann, Roberto Toro, Heike Tost, Jack Waldman, Steve C. R. Williams, Caroline Wooldridge & Marcel P. Zwiers, European Project: 0755816(2008), European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), European Project: 602805,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,AGGRESSOTYPE(2013), European Project: 603016,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,MATRICS(2014), European Project: 278948,EC:FP7:HEALTH,FP7-HEALTH-2011-two-stage,TACTICS(2012), European Project: 643051,H2020,H2020-MSCA-ITN-2014,MiND(2015), European Project: 642996,H2020,H2020-MSCA-ITN-2014,BRAINVIEW(2015), University of Pennsylvania [Philadelphia], University of Cyprus (UCY), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Universität Heidelberg [Heidelberg], Bethlehem, Richard A I [0000-0002-0714-0685], Seidlitz, Jakob [0000-0002-8164-7476], Bourgeron, Thomas [0000-0001-8164-9220], Charman, Tony [0000-0003-1993-6549], Persico, Antonio M [0000-0001-8910-4479], Lombardo, Michael V [0000-0001-6780-8619], Apollo - University of Cambridge Repository, and Bethlehem, Richard AI [0000-0002-0714-0685]
Subjects: Male, 0301 basic medicine, Autism Spectrum Disorder, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], Medicine (miscellaneous), MESH: Magnetic Resonance Imaging, 0302 clinical medicine, 130 000 Cognitive Neurology & Memory, MESH: Child, Neural Pathways, Biology (General), Child, MESH: Autism Spectrum Disorder, MESH: Child Behavior Disorders, Communication, 220 Statistical Imaging Neuroscience, Hyperconnectivity, Autism spectrum disorders, Magnetic Resonance Imaging, Autism spectrum disorder, Female, MESH: Communication, General Agricultural and Biological Sciences, MESH: Stereotyped Behavior, QH301-705.5, autism spectrum disorders, Child Behavior Disorders, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Neuroimaging, mental disorders, medicine, Biological neural network, Humans, Association (psychology), MESH: Neurodevelopmental Disorders, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], MESH: Humans, Resting state fMRI, Genetic heterogeneity, MESH: Neural Pathways, [SCCO.NEUR]Cognitive science/Neuroscience, medicine.disease, MESH: Male, 030104 developmental biology, Neurodevelopmental Disorders, Autism, Stereotyped Behavior, Neuroscience, MESH: Female, 030217 neurology & neurosurgery
Abstract: Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here, we developed a phenotypic stratification model that makes highly accurate (97–99%) out-of-sample SC = RRB, SC > RRB, and RRB > SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n = 509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show replicable differences within some networks compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC > RRB and visual association circuitry in SC = RRB. The SC = RRB subtype show hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these networks show a differential enrichment pattern with known autism-associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share many commonalities, but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry., Natasha Bertelsen et al. develop a computational model to categorize patients with autism spectrum disorder (ASD) into distinct subgroups, based on social-communicative or restricted repetitive behaviors. By integrating publicly available neuroimaging and genetic data, they report neural and molecular signatures in two of these subgroups, altogether highlighting subtle differences in neural circuitry and genomic networks that could underlie phenotypic differences among ASD patients.
Published: 2021
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15. The Use of Radial Artery for CABG: An Update

Author: Francesca Bellomo, Adelaide Iervolino, Christophe Acar, Camilla Chello, Massimo Chello, Francesco Nappi, Pierluigi Nappi, Centre cardiologique du Nord (CCN), University of Messina, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Fondazione 'Policlinico Universitario A. Gemelli' [Rome], Service de Chirurgie cardiaque et thoracique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: medicine.medical_specialty, Bypass grafting, Gastroepiploic Artery, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Review Article, 030204 cardiovascular system & hematology, Coronary Angiography, General Biochemistry, Genetics and Molecular Biology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, law, medicine.artery, Internal medicine, Medicine, Vascular Patency, Humans, 030212 general & internal medicine, Treatment Failure, Radial artery, Coronary Artery Bypass, Vein, General Immunology and Microbiology, business.industry, General Medicine, 3. Good health, medicine.anatomical_structure, surgical procedures, operative, Right coronary artery, Radial Artery, Cardiology, cardiovascular system, business, Tomography, X-Ray Computed, Artery
Abstract: International audience; We used the radial artery as a second target conduit for coronary artery bypass grafting since 1971. However, randomized clinical studies have demonstrated differences in clinical outcomes between the radial artery and other grafts because these trials are underpowered. As we proceed toward 50 years of experience with radial artery grafting, we examined the literature to define the best second-best target vessel for coronary artery bypass grafting. The literature was reviewed with emphasis, and a large number of randomized controlled trials, propensity-matched observational series, and meta-analyses were identified with a large patient population who received arterial conduit and saphenous vein grafts. The radial artery has been shown to be effective and safe when used as a second target conduit for coronary artery bypass grafting. Results and patency rates were superior to those for saphenous vein grafting. It has also been shown that the radial artery is a safe and effective graft as a third conduit into the territory of the artery right coronary artery. However, there is little evidence based on a few comparable series limiting the use of the gastroepiploic artery. In its fifth decade of use, we can finally deduced that the aorto-to-coronary radial bypass graft is the conduit of choice for coronary operations after the left internal thoracic artery to the left anterior descending artery.
Published: 2021
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16. The SAGE study: Global observational analysis of glycaemic control, hypoglycaemia and diabetes management in T1DM

Author: Felipe Lauand, Hiroshi Ikegami, Sandrine Brette, Jochen Seufert, Anne L. Peters, Jothydev Kesavadev, Eric Renard, André Gustavo Daher Vianna, Emma G. Wilmot, Valerie Pilorget, Zsolt Bosnyak, Dubravka Jurišić-Eržen, Paolo Pozzilli, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Kindai University, Curitiba Diabetes Center [Curitiba], Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Barts & The London School of Medicine and Dentistry, Queen Mary University of London (QMUL), Aixial Pharma, SANOFI Recherche, University of Southern California (USC), University of Rijeka, University of Kerala (UoK), University of Freiburg [Freiburg], University of Derby [United Kingdom], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Guerineau, Nathalie C.
Subjects: Pediatrics, endocrine system diseases, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030204 cardiovascular system & hematology, 0302 clinical medicine, Endocrinology, Clinical endpoint, adults, Insulin, Research Articles, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Incidence (epidemiology), global, 3. Good health, clinical practice, [SDV] Life Sciences [q-bio], Type 1 diabetes, glycaemic control, Research Article, Adult, hypoglycaemia, type 1 diabetes, medicine.medical_specialty, Diabetic ketoacidosis, 030209 endocrinology & metabolism, Glycemic Control, 03 medical and health sciences, Diabetes management, Diabetes mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, Aged, Glycated Hemoglobin, business.industry, nutritional and metabolic diseases, medicine.disease, Hypoglycemia, Confidence interval, Cross-Sectional Studies, Diabetes Mellitus, Type 1, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Aims: To describe glycaemic control and diabetes management in adults with type 1 diabetes (T1DM), in a real-life global setting.Materials and methods: Study of Adults' GlycEmia (SAGE) was a multinational, multicentre, single visit, non-interventional, cross-sectional study in adult patients with T1DM. Data were collected at a single visit, analysed according to predefined age groups (26-44, 45-64, and ≥65 years), and reported across different regions. The primary endpoint was the proportion of participants achieving HbA1c
Published: 2021
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17. The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus

Author: Giacomelli, Roberto, Afeltra, Antonella, Bartoloni, Elena, Berardicurti, Onorina, Bombardieri, Michele, Bortoluzzi, Alessandra, Carubbi, Francesco, Caso, Francesco, Cervera, Ricard, Ciccia, Francesco, Cipriani, Paola, Coloma-Bazán, Emmanuel, Conti, Fabrizio, Costa, Luisa, D'Angelo, Salvatore, Distler, Oliver, Feist, Eugen, Foulquier, Nathan, Gabini, Marco, Gerber, Vanessa, Gerli, Roberto, Grembiale, Rosa Daniela, Guggino, Giuliana, Hoxha, Ariela, Iagnocco, Annamaria, Jordan, Suzana, Kahaleh, Bashar, Lauper, Kim, Liakouli, Vasiliki, Lubrano, Ennio, Margiotta, Domenico, Naty, Saverio, Navarini, Luca, Perosa, Federico, Perricone, Carlo, Perricone, Roberto, Prete, Marcella, Pers, Jacques-Olivier, Pitzalis, Costantino, Priori, Roberta, Rivellese, Felice, Ruffatti, Amelia, Ruscitti, Piero, Scarpa, Raffaele, Shoenfeld, Yehuda, Triolo, Giovanni, Tzioufas, Athanasios, D’Angelo, Salvatore, Giacomelli, Roberto, Afeltra, Antonella, Bartoloni, Elena, Berardicurti, Onorina, Bombardieri, Michele, Bortoluzzi, Alessandra, Carubbi, Francesco, Caso, Francesco, Cervera, Ricard, Ciccia, Francesco, Cipriani, Paola, Coloma-Bazán, Emmanuel, Conti, Fabrizio, Costa, Luisa, D'Angelo, Salvatore, Distler, Oliver, Feist, Eugen, Foulquier, Nathan, Gabini, Marco, Gerber, Vanessa, Gerli, Roberto, Grembiale, Rosa Daniela, Guggino, Giuliana, Hoxha, Ariela, Iagnocco, Annamaria, Jordan, Suzana, Kahaleh, Bashar, Lauper, Kim, Liakouli, Vasiliki, Lubrano, Ennio, Margiotta, Domenico, Naty, Saverio, Navarini, Luca, Perosa, Federico, Perricone, Carlo, Perricone, Roberto, Prete, Marcella, Pers, Jacques-Olivier, Pitzalis, Costantino, Priori, Roberta, Rivellese, Felice, Ruffatti, Amelia, Ruscitti, Piero, Scarpa, Raffaele, Shoenfeld, Yehuda, Triolo, Giovanni, Tzioufas, Athanasios, Clinical Unit of Rheumatology, L'Aquila, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Department of Medicine [Perugia, Italy] (Rheumatology, Unit), Università degli Studi di Perugia (UNIPG), The London School of Medicine & Dentistry, Queen Mary University London, London, UK, Sant'Anna University Hospital, Partenaires INRAE, University of L'Aquila [Italy] (UNIVAQ), 'Federico II' University of Naples Medical School, Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain, Department of Medicine, Universitat Autonòma, Barcelona, University of the Study of Campania Luigi Vanvitelli, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Hospital Clínico San Carlos [Madrid, Spain], Department of Rheumatology [Zürich], Balgrist University Hospital, Helios Department of Rheumatology, Sophie-v.-Boetticher-Straße 1, 39245 Gommern, Germany, Laboratoire de Traitement de l'Information Medicale (LaTIM), Institut National de la Santé et de la Recherche Médicale (INSERM)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), UOC Reumatologia, Presidio Ospedaliero 'Santo Spirito', Pescara, Italy, University hospital of Zurich [Zurich], University of Perugia, University of Catanzaro, University of Palermo, Italy, San Bortolo Hospital, University of Padova [Padova, Italy], Rheumatology Unit, Torino, Department of Chemistry, University of Toledo, University of Toledo, Division of Rheumatology [Geneva, Switzerland], Geneva University Hospital, Geneva-Department of Internal Medicine [Genève], University of Barcelona, University of Molise [Campobasso] (UNIMOL), University of Molise, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy., Università degli studi di Bari Aldo Moro (UNIBA), University of Rome TorVergata, LabEX IGO Immunothérapie Grand Ouest, Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Queen Mary University of London, Barts and The London School of Medicine and Dentistry, School of Medicine and Dentistry, Queen Mary University of London, Institute of cancer, Department of Medicine (DIMED), University of Naples Federico II, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University [Tel Aviv], Sechenov First Moscow State Medical University, Università degli studi di Palermo - University of Palermo, National and Kapodistrian University of Athens (NKUA), Department of Pathophysiology, Medical School, University of Athens, Giacomelli, R., Afeltra, A., Bartoloni, E., Berardicurti, O., Bombardieri, M., Bortoluzzi, A., Carubbi, F., Caso, F., Cervera, R., Ciccia, F., Cipriani, P., Coloma-Bazan, E., Conti, F., Costa, L., D'Angelo, S., Distler, O., Feist, E., Foulquier, N., Gabini, M., Gerber, V., Gerli, R., Grembiale, R. D., Guggino, G., Hoxha, A., Iagnocco, A., Jordan, S., Kahaleh, B., Lauper, K., Liakouli, V., Lubrano, E., Margiotta, D., Naty, S., Navarini, L., Perosa, F., Perricone, C., Perricone, R., Prete, M., Pers, J. -O., Pitzalis, C., Priori, R., Rivellese, F., Ruffatti, A., Ruscitti, P., Scarpa, R., Shoenfeld, Y., Triolo, G., and Tzioufas, A.
Subjects: 0301 basic medicine, rheumatoid arthritis, medicine.medical_specialty, antiphospholipid syndrome, precision medicine, primary sjogren's syndrome, spondyloarthritides, systemic lupus erythematosus, systemic sclerosis, consensus, humans, autoimmune diseases, lupus erythematosus, systemic, sjogren's syndrome, Consensus, spondyloarthritide, Immunology, systemic lupus erythematosu, Sjogren's Syndrome, Context (language use), Consensu, primary Sjogren's syndrome, Autoimmune Disease, Treatment failure, Autoimmune Diseases, NO, Efficacy, 03 medical and health sciences, 0302 clinical medicine, primary Sjogren’s syndrome, Acquired immunodeficiency syndrome (AIDS), medicine, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, In patient, Intensive care medicine, Adverse effect, 030203 arthritis & rheumatology, business.industry, Precision medicine, Environmental exposure, rheumatoid arthriti, medicine.disease, 3. Good health, 030104 developmental biology, [SDV.IMM]Life Sciences [q-bio]/Immunology, business, systemic sclerosi, Human
Abstract: International audience; Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. In this work, the growing body of evidence is summarized regarding the predictive factors for drug response in patients with AIDs, applying the precision medicine principles to provide high-quality evidence for therapeutic opportunities in improving the management of these patients.
Published: 2021
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18. A multi-criteria model for the security assessment of large-infrastructure construction sites

Author: Roberto Setola, Gabriele Oliva, Luca Faramondi, Marco Tesei, Enrico Zio, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Politecnico di Milano [Milan] (POLIMI), Kyung Hee University (KHU), Centre de recherche sur les Risques et les Crises (CRC), MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
Subjects: Attractiveness, 0209 industrial biotechnology, Information Systems and Management, Computer science, media_common.quotation_subject, 0211 other engineering and technologies, Opposition (politics), Analytic hierarchy process, Context (language use), 02 engineering and technology, 020901 industrial engineering & automation, Multi-criteria decision-making, Originality, [SHS.GEST-RISQ]Humanities and Social Sciences/domain_shs.gest-risq, Safety, Risk, Reliability and Quality, ComputingMilieux_MISCELLANEOUS, Risk assessment, media_common, 021103 operations research, Law enforcement, Security assessment, 16. Peace & justice, Computer Science Applications, Critical infrastructures, Subject-matter expert, Risk analysis (engineering), Modeling and Simulation, Large construction sites, Decision model
Abstract: The construction of large infrastructures (e.g., railways, gas pipelines or power grids) is increasingly facing widespread and violent opposition of radical environmentalist and ideological groups. Therefore, it is necessary to consider also the risk related to violent opposition actions when selecting construction sites. However, the classical paradigm of risk considering probability and impact hardly applies in this context, especially because of the difficulty of assessing probabilities, due to the lack of historical and/or reliable data. This paper develops a novel framework to support the selection of construction sites for infrastructure development, considering the risk of attacks by radical or ideologically motivated groups. The main originality is that the risk of attacks is evaluated considering the attractiveness of the different locations for the attackers, based on several criteria. Specifically, a novel multi-criteria decision model is introduced, which involves fourteen criteria related to the effort required to the opponents for performing the attack and to the expected outcomes of the attack in terms of potential damage to the targeted infrastructures and visibility of the action; moreover, the lifespan of the construction site and its influence on the possibility of an attack are taken into account. The criteria have been selected by a pool of forty-four Subject Matter Experts (SMEs), i.e., security managers and experts from the academia, industry and law enforcement. With such criteria, it is possible to construct a holistic index of attractiveness and quantify it by the Sparse Analytic Hierarchy Process (SAHP), based on the evaluations of the criteria provided by the pool of SMEs. The proposed methodology is applied to support the localization of the construction sites for the cross-border section of the Turin–Lyon High Speed and High Capacity Railway, including a new base-tunnel. Indeed, such an 8.6 billion Euro project has experienced strong opposition in Italy and, hence, security has become one of the main issues to be considered. The proposed model constitutes a decision aid tool to support the selection of construction plans, considering attractiveness and impact of attack.
Published: 2021
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19. Origin and evolutionary dynamics of Hepatitis B virus (HBV) genotype E in Madagascar

Author: Michele Pier Luca Guarino, Massimo Galli, Massimo Ciccozzi, Alessandra Lo Presti, Eleonora Cella, Alessia Lai, Silvia Angeletti, Gianguglielmo Zehender, Giovanni Mottini, Jean-Michel Heraud, Soa Fy Andriamandimby, Claudia Balotta, Istituto Superiore di Sanita [Rome], Unité de Virologie [Antananarivo, Madagascar] (IPM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Réseau International des Instituts Pasteur (RIIP), Department of Biomedical and Clinical Sciences, University of Milan, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Department of Public Health and Infectious Diseases, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Digestive Disease unit, University of Rome, The human specimens (serums) were collected as part of an intregative global project leads by the Institut Pasteur of Madagascar (the ZORA project) funded by different partners according to thematics, the US Centers for Disease Control and Prevention (Cooperative Agreement Number, 5U51IP000812-02), and the Department of Homeland Security Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD) [grant number 2010-ST061-AG0001]
Subjects: 0301 basic medicine, Population Dynamics, phylogeny, Gene flow, MESH: Madagascar, MESH: Genotype, migration analysis, Databases, Genetic, Genotype, Hepatitis B virus HBV, Cluster Analysis, MESH: Phylogeny, MESH: Databases, Genetic, MESH: Evolution, Molecular, education.field_of_study, Phylogenetic tree, General Medicine, Hepatitis B, phylodynamics, 3. Good health, MESH: Hepatitis B virus, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Gene Flow, Hepatitis B virus, MESH: Bayes Theorem, Population, Biology, Microbiology, Evolution, Molecular, 03 medical and health sciences, Madagascar, Humans, Evolutionary dynamics, education, MESH: Gene Flow, MESH: Humans, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], MESH: Hepatitis B, Molecular epidemiology, Public Health, Environmental and Occupational Health, Bayes Theorem, Original Articles, MESH: Population Dynamics, MESH: Cluster Analysis, Virology, Indian ocean, 030104 developmental biology, Evolutionary biology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Parasitology
Abstract: International audience; Africa is one of the endemic regions of HBV infection. In particular, genotype E is highly endemic in most of sub-Saharan Africa such as West African countries where it represents more than 90% of total infections. Madagascar, which is classified as a high endemic area for HBV and where the most prevalent genotype is E, might play a relevant role in the dispersion of this genotype due to its crucial position in the Indian Ocean. The aim of this study was to investigate the origin, population dynamics, and circulation of HBV-E genotype in Madagascar through high-resolution phylogenetic and phylodynamic approaches. The phylogenetic tree indicated that Malagasy isolates were intermixed and closely related with sequences mostly from West African countries. The Bayesian tree highlighted three statistically supported clusters of Malagasy strains which dated back to the years 1981 (95% HPD: 1971-1992), 1986 (95% HPD: 1974-1996), and 1989 (95% HPD: 1974-2001). Population dynamics analysis showed an exponential increase in the number of HBV-E infections approximately from the year 1975 until 2000s. The migration analysis was also performed and a dynamic pattern of gene flow was identified. In conclusion, this study confirms previous observation of HBV-E circulation in Africa and expands these findings at Madagascar demonstrating its recent introduction, and highlighting the role of the African countries in the spread of HBV-E genotype. Further studies on molecular epidemiology of HBV genotype E are needed to clarify the evolutionary history of this genotype.
Published: 2017
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20. Magnetic coupling between coplanar filamentary coil antennas with uniform current

Author: Luigi Lombardi, Giulio Antonini, Francesco Ferranti, Mauro Parise, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Università degli Studi dell'Aquila (UNIVAQ), Lab-STICC_IMTA_MOM_DIM, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT), Département Micro-Ondes (IMT Atlantique - MO), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Applied Physics and Photonics, Institut Mines-Télécom [Paris] (IMT)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-Institut Mines-Télécom [Paris] (IMT)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)-École Nationale d'Ingénieurs de Brest (ENIB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)
Subjects: Imagination, Current (mathematics), media_common.quotation_subject, 02 engineering and technology, Flux linkage, symbols.namesake, loop antennas, magnetic resonance imaging (MRI), surface coils, wireless power transfer (WPT), Magnetic resonance imaging, Surface coils, 0202 electrical engineering, electronic engineering, information engineering, Magnetic resonance imaging (MRI), Electrical and Electronic Engineering, media_common, Physics, Mathematical analysis, Wireless power transfer (WPT), 020206 networking & telecommunications, Condensed Matter Physics, Inductive coupling, Atomic and Molecular Physics, and Optics, [SPI.TRON]Engineering Sciences [physics]/Electronics, Inductance, Electromagnetic coil, Product (mathematics), symbols, Loop antennas, Bessel function
Abstract: International audience; This letter presents an analytical solution for the mutual inductance of two coplanar filamentary coil antennas. First, the Sommerfeld integral describing the flux linkage between two coplanar turns is converted into a double-integral involving the product of two Bessel functions. Next, analytical integration is performed after replacing the Bessel function that depends on the radii of the coils with its Maclaurin expansion. As a result, the flux linkage between single- or multi-turn pancake coils can be expressed as a combination of spherical Hankel functions. Numerical tests are performed to show the advantages of the proposed approach in terms of accuracy and time cost.
Published: 2019
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21. Extracorporeal membrane oxygenation as treatment of graft failure after heart transplantation

Author: Salvatore Matteo Greco, Ciro Mastroianni, Massimo Chello, Pascal Leprince, Antonio Nenna, Guillaume Lebreton, Cosimo D’Alessandro, Mario Lusini, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Service de Chirurgie cardiaque et thoracique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: Inotrope, medicine.medical_specialty, medicine.medical_treatment, graft failure, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Sepsis, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Extracorporeal membrane oxygenation, Medicine, Risk factor, Stroke, Heart transplantation, business.industry, medicine.disease, Extracorporeal membrane oxygenation (ECMO), 3. Good health, surgical procedures, operative, 030228 respiratory system, Heart failure, Perspective, heart transplantation (HTx), Cardiology, Surgery, Cardiology and Cardiovascular Medicine, Complication, business
Abstract: International audience; Heart transplantation (HTx) is a valuable option in eligible patients with end-stage heart failure. The most significant complication in the immediate post-operative period is early graft failure (EGF), with a mean incidence of 20–25%. EGF is a major risk factor for death and accounts for 40–50% of early mortality after HTx. Despite the use of inotropes, EGF may persist and require temporary mechanical circulatory support. Extracorporeal membrane oxygenation (ECMO) has been investigated over the years and has proved to be a reliable strategy in patients with EGF after HTx. This study aims to review the contemporary literature on this topic. Considering short-term outcomes, 45–80% of patients were discharged alive from hospital. Duration of support is variable, with a mean duration of 4–8 days. Cannulation strategy and device selection have no differences with respect to short-term outcomes. The main causes of death are multi-organ failure, bleeding, heart failure, stroke and sepsis. Considering long-term outcomes, ECMO survivors appear to have similar survival rates to HTx patients who did not experience EGF. Also, ECMO-treated EGF, among survivors, has no detrimental effect for graft function. In conclusion, ECMO is a reliable therapeutic option to support patients with severe graft failure after HTx, providing adequate support with either central or peripheral arteriovenous cannulation. Further studies will be needed to establish the correct threshold for ECMO support and to provide long-term results.
Published: 2019
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22. Altered connectivity between cerebellum, visual, and sensory-motor networks in autism spectrum disorder: Results from the EU-AIMS Longitudinal European Autism Project

Author: Marianne Oldehinkel, Maarten Mennes, Andre Marquand, Tony Charman, Julian Tillmann, Christine Ecker, Flavio Dell’Acqua, Daniel Brandeis, Tobias Banaschewski, Sarah Baumeister, Carolin Moessnang, Simon Baron-Cohen, Rosemary Holt, Sven Bölte, Sarah Durston, Prantik Kundu, Michael V. Lombardo, Will Spooren, Eva Loth, Declan G.M. Murphy, Christian F. Beckmann, Jan K. Buitelaar, Jumana Ahmad, Sara Ambrosino, Bonnie Auyeung, Thomas Bourgeron, Carsten Bours, Michael Brammer, Claudia Brogna, Yvette de Bruijn, Bhismadev Chakrabarti, Ineke Cornelissen, Daisy Crawley, Guillaume Dumas, Jessica Faulkner, Vincent Frouin, Pilar Garcés, David Goyard, Lindsay Ham, Hannah Hayward, Joerg Hipp, Mark H. Johnson, Emily J.H. Jones, Meng-Chuan Lai, Xavier Liogier D’ardhuy, David J. Lythgoe, René Mandl, Luke Mason, Andreas Meyer-Lindenberg, Nico Mueller, Bethany Oakley, Laurence O’Dwyer, Bob Oranje, Gahan Pandina, Antonio M. Persico, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve C.R. Williams, Caroline Wooldridge, Marcel P. Zwiers, Radboud University Medical Center [Nijmegen], Monash University [Melbourne], Donders Institute for Brain, Cognition and Behaviour, Radboud university [Nijmegen], Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Goethe-University Frankfurt am Main, Universität Heidelberg [Heidelberg], Universität Zürich [Zürich] = University of Zurich (UZH), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim], University of Cambridge [UK] (CAM), Karolinska Institutet [Stockholm], Stockholm County Council, University Medical Center [Utrecht], Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Cyprus [Nicosia], Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], University of Oxford [Oxford], University of Edinburgh, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), University of Reading (UOR), Département de Chimie Moléculaire (DCM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of Nottingham, UK (UON), University of Toronto, Centre for Brain and Cognitive Development [Birkbeck College], Birkbeck College [University of London], Janssen Research & Development, This work was supported EU-AIMS, which receives support from the Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115300 and the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement No. 777394, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (Grant No. FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions, and from Autism Speaks. This work was also supported by the Netherlands Organization for Scientific Research through Vidi grants (Grant No. 864.12.003 [to CFB] and Grant No. 016.156.415 [to AFM]), from the FP7 (Grant Nos. 602805) (AGGRESSOTYPE) (to JKB), 603016 (MATRICS), and 278948 (TACTICS), and from the European Community’s Horizon 2020 Programme (H2020/2014-2020) (Grant Nos. 643051 [MiND] and 642996 (BRAINVIEW). This work received funding from the Wellcome Trust UK Strategic Award (Award No. 098369/Z/12/Z) and from the National Institute for Health Research Maudsley Biomedical Research Centre (to DM)., European Project: 602805,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,AGGRESSOTYPE(2013), European Project: 603016,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,MATRICS(2014), European Project: 278948,EC:FP7:HEALTH,FP7-HEALTH-2011-two-stage,TACTICS(2012), European Project: 643051,H2020,H2020-MSCA-ITN-2014,MiND(2015), European Project: 642996,H2020,H2020-MSCA-ITN-2014,BRAINVIEW(2015), Radboud University [Nijmegen], Universität Heidelberg [Heidelberg] = Heidelberg University, University of Cyprus [Nicosia] (UCY), University of Oxford, Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), University of Zurich, Oldehinkel, Marianne, University of Zürich [Zürich] (UZH), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris], Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and Lombardo, Michael V. [0000-0001-6780-8619]
Subjects: Male, Autism Spectrum Disorder, Autism, Functional connectivity, 0302 clinical medicine, Cerebellum, Neural Pathways, Longitudinal Studies, 10064 Neuroscience Center Zurich, Child, Visual-motor integration, Visual Cortex, Brain Mapping, medicine.diagnostic_test, 05 social sciences, Sensory networks, 220 Statistical Imaging Neuroscience, 10058 Department of Child and Adolescent Psychiatry, Magnetic Resonance Imaging, 2728 Neurology (clinical), Autism spectrum disorder, Radiology Nuclear Medicine and imaging, 10076 Center for Integrative Human Physiology, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Sensorimotor Cortex, Biological psychiatry, Psychology, 2803 Biological Psychiatry, Adult, 2805 Cognitive Neuroscience, Autism, Cerebellum, Functional connectivity, Resting-state fMRI, Sensory networks, Visual-motor integration, Radiology, Nuclear Medicine and Imaging, Cognitive Neuroscience, Neurology (clinical), Biological Psychiatry, Adolescent, Cognitive Neuroscience, Clinical Neurology, Sensory system, 610 Medicine & health, Cognitive neuroscience, 050105 experimental psychology, 03 medical and health sciences, Young Adult, Salience (neuroscience), mental disorders, medicine, Humans, 2741 Radiology, Nuclear Medicine and Imaging, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Resting-state fMRI, Biological Psychiatry, Radiology, Nuclear Medicine and Imaging, Neurology (clinical), Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Resting state fMRI, medicine.disease, Case-Control Studies, Functional magnetic resonance imaging, Neuroscience, 030217 neurology & neurosurgery
Abstract: BackgroundResting-state functional magnetic resonance imaging–based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered by small samples and a focus on a limited number of networks, with networks underlying sensory processing being largely underexamined. We aimed to comprehensively characterize ASD-related alterations within and between 20 well-characterized resting-state networks using baseline data from the EU-AIMS (European Autism Interventions—A Multicentre Study for Developing New Medications) Longitudinal European Autism Project.MethodsResting-state functional magnetic resonance imaging data was available for 265 individuals with ASD (7.5–30.3 years; 73.2% male) and 218 typically developing individuals (6.9–29.8 years; 64.2% male), all with IQ > 70. We compared functional connectivity within 20 networks—obtained using independent component analysis—between the ASD and typically developing groups, and related functional connectivity within these networks to continuous (overall) autism trait severity scores derived from the Social Responsiveness Scale Second Edition across all participants. Furthermore, we investigated case-control differences and autism trait–related alterations in between-network connectivity.ResultsHigher autism traits were associated with increased connectivity within salience, medial motor, and orbitofrontal networks. However, we did not replicate previously reported case-control differences within these networks. The between-network analysis did reveal case-control differences showing on average 1) decreased connectivity of the visual association network with somatosensory, medial, and lateral motor networks, and 2) increased connectivity of the cerebellum with these sensory and motor networks in ASD compared with typically developing subjects.ConclusionsWe demonstrate ASD-related alterations in within- and between-network connectivity. The between-network alterations broadly affect connectivity between cerebellum, visual, and sensory-motor networks, potentially underlying impairments in multisensory and visual-motor integration frequently observed in ASD.
Published: 2019
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23. Efficient estimation of cardiac conductivities: A proper generalized decomposition approach

Author: Michele Giuliano Carlino, Alessio Gizzi, Alessandro Veneziani, Simona Perotto, Alessandro Barone, Department of Mathematics and Computer Science [Emory University], Emory University [Atlanta, GA], Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Modeling Enablers for Multi-PHysics and InteractionS (MEMPHIS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Modeling and Scientific Computing [Milano] (MOX), Politecnico di Milano [Milan] (POLIMI), Alessandro Barone and Alessandro Veneziani acknowledge the support of the NSF Project DMS 1412963 and the XSEDE Consortium, Grant TG-ASC160069. Michele Giuliano Carlino wants to thank the Department of Mathematics at Emory University for hosting him during part of the research and the support of the Politecnico di Milano for the travel expenses. Simona Perotto acknowledges the INdAM-GNCS Project 2019 Advanced intrusive and non-intrusive model order reduction techniques and applications. Alessio Gizzi acknowledges the support of the Italian National Group for Mathematical Physics (GNFM-INdAM) Project Constitutive modeling of active fiber-distributed media., AB and AV acknowledge the support of the NSF Project DMS 1412963 and the XSEDE Consortium, Grant TG-ASC160069. MGC wants to thank the Department of Mathematics at Emory University for hosting him during part of the research and the support of the Politecnico di Milano for the travel expenses. SP acknowledges the support by European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Actions, grant agreement 872442 (ARIA) and the INdAM-GNCS Project 2020 Tecniche numeriche avanzate per applicazioni industriali. AG acknowledges the support of the Italian National Group for Mathematical Physics (GNFM-INdAM) Project Constitutive modeling of active fiber-distributed media., European Project: 872442,ARIA(2019), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, and Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Mathematical optimization, Physics and Astronomy (miscellaneous), Computer science, 010103 numerical & computational mathematics, Data Assimilation, 01 natural sciences, Reduction (complexity), Electrical dynamics, [NLIN]Nonlinear Sciences [physics], Computational electrophysiology, Model order reduction, Data assimilation, Proper generalized decomposition, Parameter identification, [MATH]Mathematics [math], 0101 mathematics, Estimation, Model order reduction, Numerical Analysis, Applied Mathematics, Computational Electrophysiology, Proper Generalized Decomposition, Computer Science Applications, 010101 applied mathematics, Computational Mathematics, Identification (information), Proof of concept, Modeling and Simulation, Cardiac resynchronization, Parameter Identification, Model Order Reduction, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Proper generalized decomposition
Abstract: International audience; While the potential groundbreaking role of mathematical modeling in electrophysiology has been demon-strated for therapies like cardiac resynchronization or catheter ablation, its extensive use in clinics is pre-vented by the need of an accurate customized conductivity identification. Data assimilation techniques are,in general, used to identify parameters that cannot be measured directly, especially in patient-specific set-tings. Yet, they may be computationally demanding. This conflicts with the clinical timelines and volumesof patients to analyze. In this paper, we adopt a model reduction technique, developed by F. Chinesta andhis collaborators in the last 15 years, called Proper Generalized Decomposition (PGD), to accelerate the esti-mation of the cardiac conductivities required in the modeling of the cardiac electrical dynamics. Specifically,we resort to the Monodomain Inverse Conductivity Problem (MICP) deeply investigated in the literaturein the last five years. We provide a significant proof of concept that PGD is a breakthrough in solvingthe MICP within reasonable timelines. As PGD relies on the offline/online paradigm and does not needany preliminary knowledge of the high-fidelity solution, we show that the PGD online phase estimates theconductivities in real-time for both two-dimensional and three-dimensional cases, including a patient-specificventricle.
Published: 2020
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24. RGS 9‐2 rescues dopamine D2 receptor levels and signaling in DYT 1 dystonia mouse models

Author: Maria Meringolo, Paola Bonsi, Benjamin Dehay, Valentina Vanni, Marcello D'Amelio, Rose E. Goodchild, Giulia Ponterio, Sara Migliarini, Giuseppina Martella, Evelyne Doudnikoff, Massimo Pasqualetti, Erwan Bezard, Giuseppe Sciamanna, Annalisa Tassone, Nicola Biagio Mercuri, Venetia Zachariou, Antonio Pisani, Fondazione Santa Lucia (IRCCS), University of Pisa - Università di Pisa, Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center [Dallas], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Fondazione Istituto di Ricerca e Cura Carattere Scientifico [Rome], Università degli Studi di Roma Tor Vergata [Roma], Dulbecco Telethon Institute/Department of Biology, Laboratori di Biologia Cellulare e dello Sviluppo, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione 'Istituto Neurologico Nazionale C. Mondino', Icahn School of Medicine at Mount Sinai [New York] (MSSM), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Istituto Italiano di Tecnologia [rovereto], and Dehay, Benjamin
Subjects: 0301 basic medicine, Medicine (General), striatum, [SDV]Life Sciences [q-bio], Gene Expression, QH426-470, Inbred C57BL, Mice, [SCCO]Cognitive science, 0302 clinical medicine, Receptors, Receptor, beta‐arrestin, ComputingMilieux_MISCELLANEOUS, Dystonia, Dopaminergic, Microfilament Proteins, [SDV] Life Sciences [q-bio], lysosomal degradation, Gene Knockdown Techniques, Molecular Medicine, Arrestin beta 2, Settore MED/26 - Neurologia, Signal transduction, Signal Transduction, Dystonia Musculorum Deformans, Nerve Tissue Proteins, Biology, 03 medical and health sciences, R5-920, Downregulation and upregulation, Dopamine receptor D2, Dopamine D2, medicine, RGS9, Genetics, Animals, MESH: beta‐arrestin, Animal, [SCCO.NEUR]Cognitive science/Neuroscience, Corpus Striatum, Disease Models, Animal, Mice, Inbred C57BL, Molecular Chaperones, RGS Proteins, Receptors, Dopamine D2, medicine.disease, 030104 developmental biology, Disease Models, Neuroscience, 030217 neurology & neurosurgery
Abstract: International audience; Dopamine D2 receptor signaling is central for striatal function and movement, while abnormal activity is associated with neurological disorders including the severe early-onset DYT1 dystonia. Nevertheless, the mechanisms that regulate D2 receptor signaling in health and disease remain poorly understood. Here, we identify a reduced D2 receptor binding, paralleled by an abrupt reduction in receptor protein level, in the striatum of juvenile Dyt1 mice. This occurs through increased lysosomal degradation, controlled by competition between β-arrestin 2 and D2 receptor binding proteins. Accordingly, we found lower levels of striatal RGS9-2 and spinophilin. Further, we show that genetic depletion of RGS9-2 mimics the D2 receptor loss of DYT1 dystonia striatum, whereas RGS9-2 overexpression rescues both receptor levels and electrophysiological responses in Dyt1 striatal neurons. This work uncovers the molecular mechanism underlying D2 receptor downregulation in Dyt1 mice and in turn explains why dopaminergic drugs lack efficacy in DYT1 patients despite significant evidence for striatal D2 receptor dysfunction. Our data also open up novel avenues for disease-modifying therapeutics to this incurable neurological disorder.
Published: 2018
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25. Heart failure subtypes and thromboembolic risk in patients with atrial fibrillation: The PREFER in AF - HF substudy

Author: Siller-Matula, J. M., Pecen, L., Patti, G., Lucerna, M., Kirchhof, P., Lesiak, M., Huber, K., Verheugt, F. W. A., Lang, I. M., Renda, G., Schnabel, R. B., Wachter, R., Kotecha, D., Sellal, J. -M., Rohla, M., Ricci, F., De Caterina, R., TEAM in AF group, Medizinische Universität Wien = Medical University of Vienna, Czech Academy of Sciences [Prague] (CAS), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Daiichi Sankyo Co., University of Birmingham [Birmingham], AFNet, Poznan University of Medical Sciences [Poland] (PUMS), Sigmund Freud University (SFU), University of Amsterdam [Amsterdam] (UvA), Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), University Heart Center [Hamburg], University Medical Center Göttingen (UMG), Service de Cardiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Wilhelminenspital Vienna = Wilhelminen Hospital, SELLAL, Jean-Marc, and Wilhelminenspital Vienna
Subjects: Male, medicine.medical_specialty, Ejection fraction, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Hemorrhage, Heart failure, 030204 cardiovascular system & hematology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Thromboembolism, Medicine, Humans, Prospective Studies, Registries, cardiovascular diseases, Prospective cohort study, Stroke, Aged, Atrial fibrillation, Bleeding, Anticoagulants, Atrial Fibrillation, Europe, Female, Follow-Up Studies, Heart Failure, Stroke Volume, Cardiology and Cardiovascular Medicine, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Incidence (epidemiology), Stroke volume, medicine.disease, 3. Good health, Cardiology, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cohort study
Abstract: Contains fulltext : 193224.pdf (Publisher’s version ) (Closed access) BACKGROUND AND OBJECTIVES: To assess thromboembolic and bleeding risks in patients with heart failure (HF) and atrial fibrillation (AF) according to HF type. METHODS: We analyzed 6170 AF patients from the Prevention of thromboembolic events - European Registry in Atrial Fibrillation (PREFER in AF), and categorized patients into: HF with reduced left-ventricular ejection fraction (HFrEF; LVEF60%), and no HF. Outcomes were ischemic stroke, major adverse cardiovascular and cerebral events (MACCE) and major bleeding occurring within 1-year. RESULTS: The annual incidence of stroke was linearly and inversely related to LVEF, increasing by 0.054% per each 1% of LVEF decrease (95% CI: 0.013%-0.096%; p=0.031). Patients with HFHpEF had the highest CHA2DS2-VASc score, but significantly lower stroke incidence than other HF groups (0.65%, compared to HFLpEF 1.30%; HFmrEF 1.71%; HFrEF 1.75%; trend p=0.014). The incidence of MACCE was also lower in HFHpEF (2.0%) compared to other HF groups (range: 3.8-4.4%; p=0.001). Age, HF type, and NYHA class were independent predictors of thromboembolic events. Conversely, major bleeding did not significantly differ between groups (p=0.168). CONCLUSION: Our study in predominantly anticoagulated patients with AF shows that, reduction in LVEF is associated with higher thromboembolic, but not higher bleeding risk. HFHpEF is a distinct and puzzling group, featuring the highest CHA2DS2-VASc score but the lowest residual risk of thromboembolic events, which warrants further investigation.
Published: 2018
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26. MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis

Author: Ilaria Merciaro, Maria Zingariello, Marcos F. X. B. Cavalcanti, Natalia de Isla, Patrizia Ballerini, Sergio Caputi, Oriana Trubiani, Jacopo Pizzicannella, Francesca Diomede, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Nove de Julho University [Bauru] (UNINOVE ), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, MAPK/ERK pathway, Lipopolysaccharides, Histology, Periodontal ligament stem cells, MAP Kinase Signaling System, Periodontal Ligament, [SDV]Life Sciences [q-bio], Biophysics, Biology, NFkB, Proinflammatory cytokine, 03 medical and health sciences, Adjuvants, Immunologic, Humans, hPDLSCs, Periodontitis, Porphyromonas gingivalis, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, Original Paper, Innate immune system, Membrane Glycoproteins, LPS-G, Stem Cells, NF-kappa B, Receptors, Interleukin-1, Cell Biology, biology.organism_classification, MyD88, cytokines, Cell biology, ERK, 030104 developmental biology, lcsh:Biology (General), Immunology, TLR4, Tumor necrosis factor alpha, lipids (amino acids, peptides, and proteins), Stem cell, Inflammation Mediators, Signal Transduction
Abstract: The present study was aimed at investigating whether human Periodontal Ligament Stem Cells (hPDLSCs) were capable of sensing and reacting to lipopolysaccharide from Porphyromonas gingivalis (LPS-G) which is widely recognized as a major pathogen in the development and progression of periodontitis. At this purpose hPDLCs were stimulated with 5 μg/mL LPS-G various times and the expression of toll-like receptor 4 (TLR4) was evaluated. Toll-like receptors (TLRs) play an essential role in innate immune signaling in response to microbial infections, and in particular TLR4, type-I transmembrane proteins, has been shown recognizing LPS-G. Our results put in evidence, in treated samples, an overexpression of TLR4 indicating that, hPDLSCs express a functional TLR4 receptor. In addition, LPS-G challenge induces a significant cell growth decrease starting from 24 h until 72 h of treatment. LPS-G leads the activation of the TLR4/MyD88 complex, triggering the secretion of proinflammatory cytokines cascade as: IL-1α, IL-8, TNF-α and β and EOTAXIN. Moreover, the upregulation of pERK/ERK signaling pathways and NFkB nuclear translocation was evident. On the basis of these observations, we conclude that hPDLSCs could represent an appropriate stem cells niche modeling leading to understand and evaluate the biological mechanisms of periodontal stem cells in response to LPS-G, mimicking in vitro an inflammatory process occurring in vivo in periodontal disease.
Published: 2017
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27. Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain: A longitudinal multisite study of healthy elderly subjects

Author: Pierre Payoux, Mira Didic, Régis Bordet, Manos Constantinidis, Stéphanie Bombois, Beatriz Bosch, Helene Gros-Dagnac, Magda Tsolaki, Roberto Tarducci, Moira Marizzoni, Marco Aiello, Agnese Picco, Ludovico Minati, Camillo Marra, Antonio Ferretti, Bernhard W. Müller, Carlo Cavaliere, Luca Roccatagliata, Massimo Caulo, Julien Sein, Ofer Pasternak, Andrea Soricelli, Angela Albi, Antonios Drevelegas, Jorge Jovicich, Núria Bargalló, Olivier Blin, Flavio Nobili, Jean-Philippe Ranjeva, Giada Zoccatelli, Renaud Lopes, Alberto Beltramello, David Bartrés-Faz, Ute Fiedler, Lucilla Parnetti, Jens Wiltfang, Giovanni B. Frisoni, Piero Floridi, Franco Alessandrini, Paolo Maria Rossini, University of Trento [Trento], IRCCS Fatebenefratelli - Brescia, Departament de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona (UB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA, Clinical Neurology, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Catholic University, Universität Duisburg-Essen [Essen], Magnetic Resonance Research Centre on Nervous System Diseases [Genova], Universita degli studi di Genova, Department of Health Sciences, University of Genoa, University of Genoa (UNIGE), Institut de Neurosciences de la Timone (INT), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC), Centre de recherche Jean-Pierre Aubert-Neurosciences et Cancer, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Troubles cognitifs dégénératifs et vasculaires (U1171), INSERM-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, Imagerie cérébrale et handicaps neurologiques, Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Nuclear Medicine, National Institute of Neurosurgery, University Hospital of Verona, Service of Neuroradiology [borgo trento], Ospedale Maggiore, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), SDN - Istituto di Ricerca Diagnostica e Nucleare, Department of Medicine [Perugia, Italy], Università degli Studi di Perugia (UNIPG), Perugia General Hospital, 3rd Department of Neurology, Aristotle University of Thessaloniki-G. Papanikolaou Hospital, Metacohorts Consortium, Interbalkan Medical Center of Thessaloniki, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Imagerie cérébrale et handicaps neurologiques (ICHN), Aristotle University of Thessaloniki-General Hospital of Thessaloniki George Papanikolaou, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Università degli studi di Genova = University of Genoa (UniGe), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Università degli Studi di Perugia = University of Perugia (UNIPG)
Subjects: Male, False discovery rate, Aging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Medizin, Imaging, 030218 nuclear medicine & medical imaging, spatial statistics, ddc:616.89, 0302 clinical medicine, Nuclear Medicine and Imaging, 80 and over, test-retest reproducibility, Medicine, Longitudinal Studies, brain diffusion tensor imaging, alzheimers-disease, Aged, 80 and over, Radiological and Ultrasound Technology, Brain, multisite diffusion MRI, Middle Aged, tracking, White Matter, Healthy Volunteers, free-water imaging, healthy elderly, longitudinal, test–retest reproducibility, Anatomy, Radiology, Nuclear Medicine and Imaging, Neurology, Neurology (clinical), Settore MED/26 - NEUROLOGIA, Diffusion Tensor Imaging, medicine.anatomical_structure, Brain diffusion tensor imaging, Free-water imaging, Healthy elderly, Longitudinal, Multisite diffusion MRI, Test-retest reproducibility, Female, Aged, Anisotropy, Humans, Imaging, Three-Dimensional, Reproducibility of Results, Water, Radiology, MRI, Article, White matter, 03 medical and health sciences, cerebral white-matter, Fractional anisotropy, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Radiology, Nuclear Medicine and imaging, snc, Reproducibility, reliability, business.industry, Sample size determination, substantia-nigra, Three-Dimensional, Free water, Schizophrenia, parkinsons-disease, false discovery rate, business, Nuclear medicine, 030217 neurology & neurosurgery, Diffusion MRI
Abstract: WOS:000390259700002; International audience; Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not clear if these two models differ in their test-retest reproducibility. This study compares a bi-tensor model for FWE with DTI by extending a previous longitudinal-reproducibility 3T multisite study (10 sites, 7 different scanner models) of 50 healthy elderly participants (55-80 years old) scanned in two sessions at least 1 week apart. We computed the reproducibility of commonly used DTI metrics (FA: fractional anisotropy, MD: mean diffusivity, RD: radial diffusivity, and AXD: axial diffusivity), derived either using a DTI model or a FWE model. The DTI metrics were evaluated over 48 white-matter regions of the JHU-ICBM-DTI-81 white-matter labels atlas, and reproducibility errors were assessed. We found that relative to the DTI model, FWE significantly reduced reproducibility errors in most areas tested. In particular, for the FA and MD metrics, there was an average reduction of approximately 1% in the reproducibility error. The reproducibility scores did not significantly differ across sites. This study shows that FWE improves sensitivity and is thus promising for clinical applications, with the potential to identify more subtle changes. The increased reproducibility allows for smaller sample size or shorter trials in studies evaluating biomarkers of disease progression or treatment effects. Hum Brain Mapp 38:12-26, 2017. (c) 2016 Wiley Periodicals, Inc.
Published: 2017
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28. Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation

Author: Wirsich, Jonathan, Rey, Marc, Guye, Maxime, Bénar, Christian, Lanteaume, Laura, Ridley, Ben, Confort-Gouny, Sylviane, Cassé-Perrot, Catherine, Soulier, Elisabeth, Viout, Patrick, Rouby, Franck, Lefebvre, Marie-Noëlle, Audebert, Christine, Truillet, Romain, Jouve, Elisabeth, Payoux, Pierre, Bartrés-Faz, David, Bordet, Régis, Richardson, Jill C., Babiloni, Claudio, Rossini, Paolo Maria, Micallef, Joelle, Blin, Olivier, Ranjeva, Jean-Philippe, Consortium, Pharmacog, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Parole et Langage (LPL), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), CIC-CPCET, Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'Investigation Clinique [Hôpital de la Conception - APHM] (CIC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION ), Department of Nuclear Medicine, National Institute of Neurosurgery, Departament de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona (UB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Troubles cognitifs dégénératifs et vasculaires (U1171), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-INSERM, San Raffaele Pisana IRCCS, Rome, Italy, Department of Physiology and Pharmacology Sapienza University of Rome, Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA, Clinical Neurology, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Euromov (EuroMov), Université de Montpellier (UM), Institut de Neurosciences de la Timone (INT), Centre investigation clinique - Unité de pharmacologie clinique et d'évaluations thérapeutiques (CIC-UPCET), Assistance Publique - Hôpitaux de Marseille (APHM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Subjects: Male, 0301 basic medicine, Neurology, Donepezil, EEG-fMRI, Functional connectivity, Memantine, Sleep, Anatomy, Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and Imaging, Neurology (clinical), [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, 0302 clinical medicine, Nuclear Medicine and Imaging, Neuroscience of sleep, Nootropic Agents, media_common, Brain Mapping, Sleep Stages, Brain, Electroencephalography, Magnetic Resonance Imaging, 3. Good health, Settore MED/26 - NEUROLOGIA, medicine.symptom, Radiology, Vigilance (psychology), medicine.drug, Adult, medicine.medical_specialty, media_common.quotation_subject, 03 medical and health sciences, Physical medicine and rehabilitation, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Radiology, Nuclear Medicine and imaging, Effects of sleep deprivation on cognitive performance, snc, business.industry, Sleep deprivation, 030104 developmental biology, Sleep Deprivation, Nerve Net, business, 030217 neurology & neurosurgery
Abstract: International audience; Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer's disease, the analysis of networks altered by medication would be particularly interesting. Eleven healthy subjects were recruited in the context of the European Innovative Medicines Initiative 'PharmaCog'. Each underwent five sessions of simultaneous EEG-fMRI in order to investigate the effects of donepezil and memantine before and after sleep deprivation (SD). The SD approach has been previously proposed as a model for cognitive impairment in healthy subjects. By applying network based statistics (NBS), we observed altered brain networks significantly linked to donepezil intake and sleep deprivation. Taking into account the sleep stages extracted from the EEG data we revealed that a network linked to sleep is interacting with sleep deprivation but not with medication intake. We successfully extracted the functional resting-state networks modified by donepezil intake, sleep and SD. We observed donepezil induced whole brain connectivity alterations forming a network separated from the changes induced by sleep and SD, a result which shows the utility of this approach to check for the validity of pharmacological resting-state analysis of the tested medications without the need of taking into account the subject specific vigilance.
Published: 2017
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29. First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK

Author: Augusto Gallino, Periklis Mitsakis, Emmanuel Deshayes, David Viertl, Francesco Cicone, Sébastien Baechler, Vincent Dunet, Marek Kosinski, Franz Buchegger, Silvano Gnesin, John O. Prior, Salvy-Córdoba, Nathalie, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Departement de radiologie médicale [Lausanne], Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), and CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
Subjects: lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, PET/CT, lcsh:R895-920, [SDV.CAN]Life Sciences [q-bio]/Cancer, Choroid plexuses, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Dosimetry, medicine, 68Ga-NODAGA-RGDyK, Angiogenesis, Integrin alphavbeta3, Pet/ct, Integrin αvβ3, Radiology, Nuclear Medicine and imaging, PET-CT, Urinary bladder, business.industry, Stomach, Thyroid, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Body region, Radiology, Choroid, Pancreas, Nuclear medicine, business
Abstract: Background Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RGDyK in mice. This study presents the first human dosimetry of 68Ga-NODAGA-RGDyK in the five consecutive patients included in a clinical imaging protocol of carotid atherosclerotic plaques. Five male patients underwent whole-body time-of-flight (TOF) PET/CT scans 10, 60 and 120 min after tracer injection (200 MBq). Quantification of 68Ga activity concentration was first validated by a phantom study. To be used as input in OLINDA/EXM, time-activity curves were derived from manually drawn regions of interest over the following organs: brain, thyroid, lungs, heart, liver, spleen, stomach, kidneys, red marrow, pancreas, small intestine, colon, urinary bladder and whole body. A separate dosimetric analysis was performed for the choroid plexuses. Female dosimetry was extrapolated from male data. Effective doses (EDs) were estimated according to both ICRP60 and ICRP103 assuming 30-min and 1-h voiding cycles. Results The body regions receiving the highest dose were urinary bladder, kidneys and choroid plexuses. For a 30-min voiding cycle, the EDs were 15.7 and 16.5 μSv/MBq according to ICRP60 and ICRP103, respectively. The extrapolation to female dosimetry resulted in organ absorbed doses 17% higher than those of male patients, on average. The 1-h voiding cycle extrapolation resulted in EDs of 19.3 and 19.8 μSv/MBq according to ICRP60 and ICRP103, respectively. A comparison is made with previous mouse dosimetry and with other human studies employing different RGD-based radiopharmaceuticals. Conclusions According to ICRP60/ICRP103 recommendations, an injection of 200 MBq 68Ga-NODAGA-RGDyK leads to an ED in man of 3.86/3.92 mSv. For future therapeutic applications, specific attention should be directed to delivered dose to kidneys and potentially also to the choroid plexuses. Trial registration Clinical trial.gov, NCT01608516
Published: 2017
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30. A possible desensitized state conformation of the human α7 nicotinic receptor: A molecular dynamics study

Author: Grazia Cottone, Thérèse E. Malliavin, Luca Maragliano, Letizia Chiodo, Chiodo, L, Malliavin, TE, Maragliano, L, Cottone, G, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Istituto Italiano di Tecnologia (IIT), Università degli studi di Palermo - University of Palermo, University College Dublin [Dublin] (UCD), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, alpha7 Nicotinic Acetylcholine Receptor, Stereochemistry, Pyridines, Biophysics, Molecular Dynamics Simulation, Biochemistry, 03 medical and health sciences, Molecular dynamics, medicine, Humans, Homology modeling, nicotinic receptor, epibatidine, molecular dynamics, inactive state, Ion channel, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Chemistry, Protein Stability, Organic Chemistry, Hydrogen Bonding, Bridged Bicyclo Compounds, Heterocyclic, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin), Protein Structure, Tertiary, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Electrophysiology, 030104 developmental biology, Nicotinic agonist, α7 nicotinic receptor, Epibatidine, Ligand-gated ion channel, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], medicine.drug
Abstract: International audience; The determination of the conformational states corresponding to diverse functional roles of ligand gated ion channels is subject of intense investigation with various techniques, from X-rays structure determination to electrophysiology and computational modeling. Even with a certain number of structures becoming recently available, only few major structural features distinguishing conductive open channel from the non conductive resting protein have been highlighted, while high-resolution details are still missing. The characterization of the desensitized conformation(s) is even more complex, and only few specific characteristics have been identified. Furthermore, experimental data provide conflicting information for different ion channels, adding further complexity to the topic.Desensitization is defined as the transition of the agonist-bound open channel into an ion channel configuration inactive even in the presence of agonists. In this work, we analyze a conformation corresponding to a non conductive state obtained via molecular dynamics simulations of a homology model of the human α7 nicotinic receptor complexed with agonists. We highlight some characteristics that could associate it to a desensitized state. The obtained structure is assessed against experimental data for other ligand gated ion channels that have been putatively associated to active, inactive and desensitized conditions.
Published: 2017
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31. Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

Author: Moira Marizzoni, Lucilla Parnetti, Pierre Payoux, Giovanni B. Frisoni, Claudio Babiloni, Tilman Hensch, José Luis Molinuevo, Pieter Jelle Visser, Jens Wiltfang, Nicola Salvadori, Camillo Marra, Annebet E. Leeuwis, Jill C. Richardson, Rosemary A. Abbott, Yen Ying Lim, Jorge Jovicich, Jean-Philippe Ranjeva, Bernhard W. Müller, Diego Albani, Pradeep J. Nathan, Elena Rolandi, Mira Didic, Magda Tsolaki, Samantha Galluzzi, Peter Schönknecht, Lucia Farotti, Nicola Girtler, Paolo Maria Rossini, Gianluigi Forloni, Olivier Blin, Flavio Nobili, David Bartrés-Faz, Andrea Soricelli, Régis Bordet, J. Pariente, IRCCS Fatebenefratelli - Brescia, San Raffaele Pisana IRCCS, Rome, Italy, Department of Physiology and Pharmacology Sapienza University of Rome, Departament de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona (UB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Medicine [Perugia, Italy], Università degli Studi di Perugia (UNIPG), University Hospital Leipzig, University of Trento [Trento], Catholic University, Clinical Neurophysiology Service, Dept of Endocrinological and Metabolic Sciences, University of Ge, Centre Mémoire de Ressources et de Recherche [CHU de Toulouse, Hôpital Purpan], Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Department of Nuclear Medicine, National Institute of Neurosurgery, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA, Clinical Neurology, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), SDN - Istituto di Ricerca Diagnostica e Nucleare, 3rd Department of Neurology, Aristotle University of Thessaloniki-General Hospital of Thessaloniki George Papanikolaou, Metacohorts Consortium, Department of Psychiatry and Neuropsychology, University of Maastricht, Universität Duisburg-Essen [Essen], Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre investigation clinique - Unité de pharmacologie clinique et d'évaluations thérapeutiques (CIC-UPCET), Assistance Publique - Hôpitaux de Marseille (APHM), IRCCS San Giovanni, Laboratory of Epidemiology and Neuroimaging, Brescia, Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Università degli Studi di Perugia = University of Perugia (UNIPG), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Centre Mémoire [CHU de Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Aristotle University of Thessaloniki-G. Papanikolaou Hospital, Troubles cognitifs dégénératifs et vasculaires (U1171), INSERM-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Neurology, and Amsterdam Neuroscience - Neurodegeneration
Subjects: 0301 basic medicine, Male, Aging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Medizin, Neuropsychological Tests, Hippocampus, ddc:616.89, 0302 clinical medicine, Cerebrospinal fluid, Cognition, Mild cognitive impairment (MCI), Aged, 80 and over, medicine.diagnostic_test, General Neuroscience, Cambridge Neuropsychological Test Automated Battery, Middle Aged, Alzheimer's disease, Magnetic Resonance Imaging, Amyloid, CANTAB, Cognitive assessment, CSF, Hippocampal volume, Mild cognitive impairment, Prodromal, Tau, Neuroscience (all), Neurology (clinical), Developmental Biology, Geriatrics and Gerontology, Settore MED/26 - NEUROLOGIA, Geriatric Depression Scale, Female, Psychology, Elementary cognitive task, Neuroimaging, tau Proteins, 03 medical and health sciences, mental disorders, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Cognitive Dysfunction, Effects of sleep deprivation on cognitive performance, Aged, Amyloid beta-Peptides, Magnetic resonance imaging, medicine.disease, Peptide Fragments, 030104 developmental biology, Early Diagnosis, Neuroscience, 030217 neurology & neurosurgery, Biomarkers
Abstract: Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.
Published: 2017
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32. Genetic Diversity of Hepatitis B Virus (HBV) in Madagascar

Author: Andriamandimby, Soa Fy, Presti, Alessandra, Lai, Alessia, Olive, Marie-Marie, Angeletti, Silvia, De Florio, Lucia, Cella, Eleonora, Razafindramparany, Minoharimbola, Ravalohery, Jean-Piere, Andriamamonjy, Seta, Gioffrè, Sonia, Zehender, Gianguglielmo, Mottini, Giovanni, Ciccozzi, Massimo, Heraud, Jean-Michel, Unité de Virologie [Antananarivo, Madagascar] (IPM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Istituto Superiore di Sanita [Rome], Department of Biomedical and Clinical Sciences, University of Milan, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], and Funded by- US Centers for Disease Control and Prevention. Grant Number: 5U51IP000812-02- Department of Homeland Security Center of Excellence for Emerging and Zoonotic Animal Diseases. Grant Number: 2010-ST061-AG0001
Subjects: Male, MESH: Sequence Analysis, DNA, Hepatitis B virus < Virus classification, Epidemiology, Polymerase Chain Reaction, MESH: Genotype, MESH: Madagascar, MESH: Aged, 80 and over, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Prevalence, MESH: Genetic Variation, MESH: Phylogeny, Phylogeny, MESH: Evolution, Molecular, Aged, 80 and over, MESH: Aged, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, MESH: Middle Aged, Middle Aged, Hepatitis B, MESH: Hepatitis B virus, MESH: Young Adult, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Adult, Gene Flow, Adolescent, Genotype, Evolution, Evolution, Molecular, Young Adult, MESH: Cross-Sectional Studies, Madagascar, Humans, MESH: Gene Flow, MESH: Prevalence, Aged, MESH: Adolescent, MESH: Humans, MESH: Hepatitis B, Genetic Variation, MESH: Adult, MESH: Polymerase Chain Reaction, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Sequence Analysis, DNA, MESH: Male, MESH: DNA, Viral, Cross-Sectional Studies, DNA, Viral, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, hepatitis B virus, MESH: Female
Abstract: Hepatitis B virus (HBV) is a DNA virus belonging to Hepadnaviridae family. Chronic infection with HBV is one major risk factor of hepatic disease. In Madagascar, former studies classified the country as part of high endemic area, as HBV prevalence can reach 23% in general population. However, this prevalence differs largely between urban and rural areas and is estimated to be, respectively, 5% and 26%. The aims of the present study were to describe the genetic diversity of HBV strains from different regions of Madagascar, and to describe the viral gene flow throughout the country by using phylogenetic analysis. This is the first large-scale molecular and phylogenetic study analyzing HBV sequences from 28 different Malagasy areas, never sampled in the past. In this study, the most prevalent genotype/sub-genotypes was E. Migration analysis showed a gene flow from zone 3 (rural) to zone 2 (suburban), and a greater gene flow from the middle part of Madagascar to the north than to the south. It is important to study the HBV infections in Madagascar and to monitor the potential spread of this viral strain inside this country. J. Med. Virol. 88:2138-2144, 2016. © 2016 Wiley Periodicals, Inc.
Published: 2016
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33. Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone

Author: Claire Benetollo, Edith Bonnelye, Vincenzo Castronovo, Jennifer Rieusset, Thomas J. Rosol, Mathilde Bouchet, Anais Fradet, Akeila Bellahcene, Lamia Bouazza, Carine Delliaux, Philippe Clézardin, Martine Duterque-Coquillaud, Martine Croset, Casina Kan, Francesco Pantano, Xavier Leroy, Manon Gervais, Jane E. Aubin, Geoffrey Vargas, Yohann Bala, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161 (M3T), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), College of Veterinary Medicine [Colombus], Ohio State University [Columbus] (OSU), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université de Liège, University of Toronto, This work was supported by the Association pour la recherche sur les tumeurs de la prostate (ARTP), the National Center for Scientific Research (CNRS) to EB and by the National Institute of Health and Medical Research (INSERM) and the University of Lyon1. AF was supported by the Ligue nationale contre le cancer and the Fondation pour la recherche médicale (FRM), MB, MG by the French National Cancer Institute (INCa), CD by the Institut Pasteur/Région Nord-Pas-de-Calais, GV by the Labex DEVweCAN and AB from the Belgian National Fund for Scientific Research. CK is a recipient of the H2020 Marie Sklodowska-Curie Individual Fellowship under agreement number (655777-miROMeS)., We are grateful to the Animalerie Lyon Est Conventionnelle (ALECS) and to D. Sahay for discussion., Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, MESH: Signal Transduction, MESH: Wnt-5a Protein/metabolism, Male, Vascular Endothelial Growth Factor A, Pathology, MESH: Cell Adhesion Molecules/metabolism, [SDV]Life Sciences [q-bio], Cell, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, bone, Prostate cancer, Estrogen-related receptor alpha, Mice, 0302 clinical medicine, MESH: Prostatic Neoplasms, Castration-Resistant/genetics, MESH: Tumor Microenvironment, Tumor Microenvironment, Medicine, MESH: Animals, MESH: Transforming Growth Factor beta1/metabolism, MESH: Gene Expression Regulation, Neoplastic, prostate cancer, 3. Good health, Gene Expression Regulation, Neoplastic, Prostatic Neoplasms, Castration-Resistant, medicine.anatomical_structure, Oncology, Receptors, Estrogen, 030220 oncology & carcinogenesis, MESH: Bone Neoplasms/metabolism, Disease Progression, MESH: Disease Progression, MESH: Bone Neoplasms/genetics, Research Paper, Signal Transduction, medicine.medical_specialty, Stromal cell, MESH: Cell Line, Tumor, medicine.drug_class, MESH: Vascular Endothelial Growth Factor A/metabolism, [SDV.CAN]Life Sciences [q-bio]/Cancer, Bone Neoplasms, Periostin, Wnt-5a Protein, Transforming Growth Factor beta1, 03 medical and health sciences, Stroma, MESH: Prostatic Neoplasms, Castration-Resistant/metabolism, Cell Line, Tumor, Animals, Humans, MESH: Receptors, Estrogen/metabolism, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Mice, MESH: Humans, MESH: Receptors, Estrogen/genetics, business.industry, ERRα, MESH: Bone Neoplasms/secondary, medicine.disease, microenvironment, MESH: Male, 030104 developmental biology, Tumor progression, Estrogen, Cancer research, business, Cell Adhesion Molecules, MESH: Neoplasm Transplantation, Neoplasm Transplantation
Abstract: International audience; Bone metastases are one of the main complications of prostate cancer and they are incurable. We investigated whether and how estrogen receptor-related receptor alpha (ERRalpha) is involved in bone tumor progression associated with advanced prostate cancer. By meta-analysis, we first found that ERRalpha expression is correlated with castration-resistant prostate cancer (CRPC), the hallmark of progressive disease. We then analyzed tumor cell progression and the associated signaling pathways in gain-of-function/loss-of-function CRPC models in vivo and in vitro. Increased levels of ERRalpha in tumor cells led to rapid tumor progression, with both bone destruction and formation, and direct impacts on osteoclasts and osteoblasts. VEGF-A, WNT5A and TGFbeta1 were upregulated by ERRalpha in tumor cells and all of these factors also significantly and positively correlated withERRalpha expression in CRPC patient specimens. Finally, high levels of ERRalpha in tumor cells stimulated the pro-metastatic factor periostin expression in the stroma, suggesting that ERRalpha regulates the tumor stromal cell microenvironment to enhance tumor progression. Taken together, our data demonstrate that ERRalpha is a regulator of CRPC cell progression in bone. Therefore, inhibiting ERRalpha may constitute a new therapeutic strategy for prostate cancer skeletal-related events.
Published: 2016
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34. A new genotyping scheme based on MLVA for inter-laboratory surveillance of Streptococcus pyogenes

Author: Valentina Pittiglio, Florigio Lista, Giovanni Gherardi, Lucilla Baldassarri, Christine Pourcel, Giuseppe D'Avenio, Andrea Ciammaruconi, Roberta Creti, Monica Imperi, Dept. of Infectious, Parasitic and Immune-mediated Disease, Istituto Superiore di Sanità [Rome, Italy], Health Corps Italian Army, Department of Molecular Biology, Immunology and Experimental Medicine, Army Medical and Veterinary Research Center, Dept. of Technology and Health, Istituto Superiore di Sanità, Rome, Dept. of Medicine, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University Campus Bio-Medico, Rome, Institut de Biologie Intégrative de la Cellule ( I2BC ), Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Sud - Paris 11 ( UP11 ), and Istituto Superiore di Sanità (ISS)
Subjects: 0301 basic medicine, Microbiology (medical), Genotyping Techniques, Streptococcus pyogenes, [SDV]Life Sciences [q-bio], 030106 microbiology, Minisatellite Repeats, Computational biology, Biology, Multiple Loci VNTR Analysis, medicine.disease_cause, Microbiology, 03 medical and health sciences, Bacterial Proteins, Streptococcal Infections, medicine, Pulsed-field gel electrophoresis, Humans, Typing, Inter-laboratory, Molecular Biology, Genotyping, [ SDV ] Life Sciences [q-bio], S. pyogenes, MLVA, Group A streptococcus, PFGE, bacterial infections and mycoses, Virology, Electrophoresis, Gel, Pulsed-Field, emm typing, Multilocus sequence typing, Multilocus Sequence Typing, MLST
Abstract: International audience; A newly developed MLVA seven-loci scheme for Streptococcus pyogenes is described. The method can be successfully applied by using both agarose gel with visual inspections of bands and Lab on Chip technology. The potential of the present MLVA has been tested on a collection of 100 clinical GAS strains representing the most common emm types found in high-income countries plus 18 published gap-free genomes, in comparison to PFGE and MLST. The MLVA analysis defined 30 MLVA types with ten out of the considered 15 emm types exhibiting multiple and specific MLVA types. In only one occasion the same MLVA profile was shared between isolates belonging to two different emm types. A robust congruency between the methods was observed, with MLVA discriminating within clonal complexes as defined by PFGE or MLST. This new MLVA scheme can be adopted as a quick, low-cost and reliable typing method to track the short-term diffusion of GAS clones in inter-laboratory-based surveillance.
Published: 2016
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35. Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques

Author: Marchitelli, Rocco, Minati, Ludovico, Marizzoni, Moira, Bosch, Beatriz, Bartrés Faz, David, Müller, Bernhard W., Wiltfang, Jens, Fiedler, Ute, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio, Blin, Oliver, Bombois, Stephanie, Lopes, Renaud, Bordet, Régis, Sein, Julien, Ranjeva, Jean Philippe, Didic, Mira, Gros Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Bargalló, Núria, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Cavaliere, Carlo, Soricelli, Andrea, Parnetti, Lucilla, Tarducci, Roberto, Floridi, Piero, Tsolaki, Magda, Constantinidis, Manos, Drevelegas, Antonios, Rossini, Paolo Maria, Marra, Camillo, Schönknecht, Peter, Hensch, Tilman, Hoffmann, Karl Titus, Kuijer, Joost P., Visser, Pieter Jelle, Barkhof, Frederik, Frisoni, Giovanni B., Jovicich, Jorge, Physics and medical technology, Amsterdam Neuroscience - Brain Imaging, Neurology, Radiology and nuclear medicine, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, Frisoni, Giovanni, University of Trento [Trento], IRCCS Fatebenefratelli - Brescia, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Departament de Psiquiatria i Psicobiologia Clinica, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Magnetic Resonance Research Centre on Nervous System Diseases [Genova], Università degli studi di Genova = University of Genoa (UniGe), Clinical Neurophysiology Service, Dept of Endocrinological and Metabolic Sciences, University of Ge, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Metacohorts Consortium, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Imagerie cérébrale et handicaps neurologiques (ICHN), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine Nucléaire - Pierre-Paul Riquet [CHU Toulouse], Pôle imagerie médicale [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), University Hospital of Verona, Service of Neuroradiology [borgo trento], Ospedale Maggiore, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), SDN - Istituto di Ricerca Diagnostica e Nucleare, Università degli Studi di Perugia = University of Perugia (UNIPG), Perugia General Hospital, 3rd Department of Neurology, Aristotle University of Thessaloniki-General Hospital of Thessaloniki George Papanikolaou, Interbalkan Medical Center of Thessaloniki, Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA, Clinical Neurology, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), University Hospital Leipzig, Department of Psychiatry and Neuropsychology, University of Maastricht, VU University Medical Center [Amsterdam], IRCCS San Giovanni, Laboratory of Epidemiology and Neuroimaging, Brescia, Universität Duisburg-Essen [Essen], Universita degli studi di Genova, Department of Health Sciences, University of Genoa, University of Genoa (UNIGE), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Université Pierre et Marie Curie - Paris 6 (UPMC), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine Nucléaire [Toulouse], CHU Toulouse [Toulouse], Università degli Studi di Perugia (UNIPG), and Catholic University
Subjects: Male, Default mode network, Independent component analysis, Multisite, Physiological noise correction, Resting-state networks, Task-free fMRI, Test-retest reliability, Neurology (clinical), Anatomy, Neurology, Radiology, Nuclear Medicine and Imaging, Radiological and Ultrasound Technology, Rest, multisite, ddc:616.89, default mode network, Nuclear Medicine and Imaging, Neural Pathways, Humans, Longitudinal Studies, physiological noise correction, Research Articles, Aged, Retrospective Studies, Brain Mapping, [SCCO.NEUR]Cognitive science/Neuroscience, test-retest reliability, independent component analysis, resting-state networks, task-free fMRI, Brain, Reproducibility of Results, Middle Aged, Magnetic Resonance Imaging, Settore MED/26 - NEUROLOGIA, Regression Analysis, Female, Radiology, human activities
Abstract: Understanding how to reduce the influence of physiological noise in resting state fMRI data is important for the interpretation of functional brain connectivity. Limited data is currently available to assess the performance of physiological noise correction techniques, in particular when evaluating longitudinal changes in the default mode network (DMN) of healthy elderly participants. In this 3T harmonized multisite fMRI study, we investigated how different retrospective physiological noise correction (rPNC) methods influence the within-site test-retest reliability and the across-site reproducibility consistency of DMN-derived measurements across 13 MRI sites. Elderly participants were scanned twice at least a week apart (five participants per site). The rPNC methods were: none (NPC), Tissue-based regression, PESTICA and FSL-FIX. The DMN at the single subject level was robustly identified using ICA methods in all rPNC conditions. The methods significantly affected the mean z-scores and, albeit less markedly, the cluster-size in the DMN; in particular, FSL-FIX tended to increase the DMN z-scores compared to others. Within-site test-retest reliability was consistent across sites, with no differences across rPNC methods. The absolute percent errors were in the range of 5-11% for DMN z-scores and cluster-size reliability. DMN pattern overlap was in the range 60-65%. In particular, no rPNC method showed a significant reliability improvement relative to NPC. However, FSL-FIX and Tissue-based physiological correction methods showed both similar and significant improvements of reproducibility consistency across the consortium (ICC = 0.67) for the DMN z-scores relative to NPC. Overall these findings support the use of rPNC methods like tissue-based or FSL-FIX to characterize multisite longitudinal changes of intrinsic functional connectivity. Hum Brain Mapp 37:2114-2132, 2016. © 2016 Wiley Periodicals, Inc.
Published: 2016
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36. Azaphilone pigments from Talaromyces alboverticillius

Author: Zelena, M., Dufossé, Laurent, Giuffrida, Daniele, Cacciola, Francesco, Ceslova, L., Venkatachalam, Mekala, Fouillaud, Mireille, Girard-Valenciennes, Emmanuelle, Dugo, Paola, Mondello, L., Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de La Réunion (UR), Dipartimento di Scienze dell'Ambiente, della Sicurezza, del Territorio, degli Alimenti e della Salute, Università degli studi di Messina, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), and Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute
Subjects: [SDV]Life Sciences [q-bio], LCSNSA, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; no abstract
Published: 2016

37. Characterization of the C50 carotenoids produced by strains of the cheese-ripening bacterium Arthrobacter arilaitensis

Author: Yves Le Mao, Francesco Cacciola, Paola Donato, Yanis Caro, Laurent Dufossé, Daniele Giuffrida, Nuthathai Sutthiwong, Christophe Monnet, Paola Dugo, Emmanuelle Girard-Valenciennes, Mireille Fouillaud, Dipartimento di Scienze dell'Ambiente, della Sicurezza, del Territorio, degli Alimenti e della Salute, Università degli studi di Messina, Thailand Institute of Scientific and Technological Research (TISTR), Thailand Institute of Scientific and Technological Research, Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de La Réunion (UR), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Université de La Réunion - Faculté des Sciences et Technologies (FST), laboratoire de biotechnologie agroalimentaire, Génie et Microbiologie des Procédés Alimentaires (GMPA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Laboratoire ANTiOX, and Université de Brest (UBO)
Subjects: 0301 basic medicine, chemistry.chemical_classification, Chromatography, Elution, 030106 microbiology, Cheese ripening, Atmospheric-pressure chemical ionization, Biology, biology.organism_classification, Applied Microbiology and Biotechnology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Terpenoid, 03 medical and health sciences, Pigment, chemistry, Red-smear cheese, Corynebacterium-glutamicum, Brevibacterium-linens, Biosynthetic--pathway, C-50, C50-carotenoids, Microorganisms, Pigmentation, visual_art, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Mass spectrum, visual_art.visual_art_medium, Carotenoid, Bacteria, Food Science
Abstract: International audience; Pigments were extracted from cheese-ripening bacteria belonging to the species Arthrobacter arilaitensis, which plays a role in the colour of cheese. A chromatographic method was applied to characterise the pigment profile. Based on the UVevisible (UVevis) spectra, the mass spectra, and the elution order, eight different carotenoids were identified from the strains. Four of the pigments, namely, all-E-decaprenox-anthin, all-E-sarcinaxanthin, 9-Z-decaprenoxanthin and 15-Z-decaprenoxanthin, which were present as free-form main carotenoids (i.e., non-glycosylated), have been characterised by their UVevis and mass spectra, both in atmospheric-pressure chemical ionisation negative [APCI (À)] and positive modes. The other minor carotenoids, namely, sarcinaxanthin monoglucoside pentaacetate, decaprenoxanthin mon-oglucoside, decaprenoxanthin diglucoside, decaprenoxanthin-C16:0 (decaprenoxanthin-palmitate), present in very low amounts, were only detected in the APCI (À) ionisation mode. Our results provide the first chemical characterisation of the pigments produced by cheese-ripening A. arilaitensis strains, which has not previously been reported.
Published: 2016
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38. Alcohol and wine in relation to cancer and other diseases

Author: A. Giacosa, A. F. Adam Blondon, S. Baer Sinnott, R. Barale, L. Bavaresco, G. Di Gaspero, L. Dugo, R. Curtis Ellison, J. R. Fernandez, V. Gerbi, D. Gifford, J. Janssens, C. La Vecchia, E. Negri, M. Pezzotti, L. Santi, M. Rondanelli, University of Genoa (UNIGE), Policlinico di Monza, Partenaires INRAE, Unité de Recherche Génomique Info (URGI), Institut National de la Recherche Agronomique (INRA), Oldways Preservation Trust, Universita degli studi di Pisa, Agricultural Research Council (CRA), Dipartimento di Scienze Agrarie ed Ambientali, Università degli Studi di Udine - University of Udine [Italie], Istituto di Genomica Applicata, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Boston University [Boston] (BU), Universita di Torino, European Cancer Prevention Organization, Istituto di Ricerce Farmacologiche Mario Negri, Università degli Studi di Milano [Milano] (UNIMI), Department of Biotechnology, University of Verona (UNIVR), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Università degli Studi di Pavia, Azienda di Servizi alla Persona di Pavia, A. Giacosa, A. F. Adam Blondon, S. Baer Sinnott, R. Barale, L. Bavaresco, G. Di Gaspero, L. Dugo, R. Curtis Ellison, J. R. Fernandez, V. Gerbi, D. Gifford, J. Janssen, C. La Vecchia, E. Negri, M. Pezzotti, L. Santi, M. Rondanelli, Giacosa A, Adam-Blondon AF, Baer-Sinnott S, Barale R, Bavaresco L, Di Gaspero G, Dugo L, Ellison RC, Gerbi V, Gifford D, Janssens J, La Vecchia C, Negri E, Pezzotti M, Santi L, and Rondanelli M
Subjects: Polyphenol, Cancer Research, Alcohol Drinking, Epidemiology, [SDV]Life Sciences [q-bio], alcohol consumption, media_common.quotation_subject, Alcohol, resveratrol, Resveratrol, Bioinformatics, Neuroprotection, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nutraceutical, Breast cancer, Neoplasms, genomics, medicine, Humans, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, cancer, wine, polyphenols, 030304 developmental biology, media_common, Wine, 0303 health sciences, alcohol, business.industry, Public Health, Environmental and Occupational Health, Longevity, food and beverages, Cancer, medicine.disease, 3. Good health, Biotechnology, Oncology, chemistry, Cardiovascular Diseases, 030220 oncology & carcinogenesis, Genomic, Settore AGR/03 - ARBORICOLTURA GENERALE E COLTIVAZIONI ARBOREE, business
Abstract: Heavy alcohol consumption is associated with increased overall mortality, cancer, liver, and cardiovascular diseases; but low doses of alcohol (up to one drink per day) are not associated with the risk of any cancer site with the exception of breast cancer and possibly of oral and pharyngeal cancers. Moreover, recent evidence indicates that moderate alcohol and specifically wine intake provides cardioprotection and neuroprotection and may increase longevity. Various experimental data hypothesize a potential cancer chemopreventive role of some grape extracts, and complete sequencing of the grapevine genome has revealed genes responsible for the synthesis of health-promoting compounds (resveratrol and other polyphenols), thus advocating the development of future potential nutraceutical strategies. This focuses on the pros and cons of moderate alcohol and wine consumption and opens a debate on this topic. European Journal of Cancer Prevention 21:103-108 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. RI gerbi, vincenzo/G-4457-2012
Published: 2012
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39. Gentle Nearest Neighbors Boosting over Proper Scoring Rules

Author: Frank Nielsen, Roberto D'Ambrosio, Richard Nock, Michel Barlaud, Wafa Bel Haj Ali, Centre de Recherche en Economie, Gestion, Modélisation et Informatique Appliquée (CEREGMIA), Université des Antilles et de la Guyane (UAG), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Projet MEDIACODING, Signal, Images et Systèmes (Laboratoire I3S - SIS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Medical Informatics and Computer Science Laboratory, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Sony Computer Science Laboratories [Tokyo, Japan], and Sony France SA
Subjects: Boosting (machine learning), business.industry, Computer science, Applied Mathematics, [INFO.INFO-MM]Computer Science [cs]/Multimedia [cs.MM], Machine learning, computer.software_genre, Support vector machine, Stochastic gradient descent, Computational Theory and Mathematics, Rate of convergence, Artificial Intelligence, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Computer Vision and Pattern Recognition, Artificial intelligence, AdaBoost, business, computer, Software
Abstract: Tailoring nearest neighbors algorithms to boosting is an important problem. Recent papers study an approach, UNN, which provably minimizes particular convex surrogates under weak assumptions. However, numerical issues make it necessary to experimentally tweak parts of the UNN algorithm, at the possible expense of the algorithm's convergence and performance. In this paper, we propose a lightweight Newton-Raphson alternative optimizing proper scoring rules from a very broad set, and establish formal convergence rates under the boosting framework that compete with those known for UNN. To the best of our knowledge, no such boosting-compliant convergence rates were previously known in the popular Gentle Adaboost's lineage. We provide experiments on a dozen domains, including Caltech and SUN computer vision databases, comparing our approach to major families including support vector machines, (Ada)boosting and stochastic gradient descent. They support three major conclusions: (i) GNNB significantly outperforms UNN, in terms of convergence rate and quality of the outputs, (ii) GNNB performs on par with or better than computationally intensive large margin approaches, (iii) on large domains that rule out those latter approaches for computational reasons, GNNB provides a simple and competitive contender to stochastic gradient descent. Experiments include a divide-and-conquer improvement of GNNB exploiting the link with proper scoring rules optimization.
Published: 2015
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40. Differences between kinematic synergies and muscle synergies during two-digit grasping

Author: Tagliabue, Michele, Ciancio, Anna Lisa, Brochier, Thomas, Eskiizmirliler, Selim, Maier, Marc A., Fédération de Recherche en Neurosciences, Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), Centre de neurophysique, physiologie, pathologie, Université Paris Descartes - Paris 5 (UPD5) - Centre National de la Recherche Scientifique (CNRS), Laboratory of Biomedical Robotic and Biomicrosystem, Università Campus Bio-Medico di Roma, Roma, Italy, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU) - Assistance Publique - Hôpitaux de Marseille (APHM) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot, Sorbonne Paris Cité, Paris, France, Université Paris Diderot - Paris 7 (UPD7), Centre de neurophysique, physiologie, pathologie (UMR 8119), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Fédération de Recherche en Neurosciences (FR 3636), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Biomedical Robotic and Biomicrosystem, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Life Sciences Department, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Centre de neurophysique, physiologie, pathologie ( UMR 8119 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Fédération de Recherche en Neurosciences ( FR 3636 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Università Campus Bio-Medico di Roma (UCBM), Institut de Neurosciences de la Timone ( INT ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Université Paris Diderot - Paris 7 ( UPD7 ), and Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], EMG ACTIVATION PATTERNS, PRECISION-GRIP, kinematic synergy, Tagliabue et al, movement kinematics, lcsh:RC321-571, precision grip, EMG, INPUT, [ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT], MODULATION, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, FINGER MOVEMENTS, REACH-TO-GRASP, Original Research, OBJECT, muscle synergy, PREHENSION, body regions, [SDV] Life Sciences [q-bio], [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], HAND SYNERGIES, FORCE-PRODUCTION, Movement vs muscle synergies, Neuroscience
Abstract: International audience; The large number of mechanical degrees of freedom of the hand is not fully exploited during actual movements such as grasping. Usually, angular movements in various joints tend to be coupled, and EMG activities in different hand muscles tend to be correlated. The occurrence of covariation in the former was termed kinematic synergies, in the latter muscle synergies. This study addresses two questions: (i) Whether kinematic and muscle synergies can simultaneously accommodate for kinematic and kinetic constraints. (ii) If so, whether there is an interrelation between kinematic and muscle synergies. We used a reach-grasp-and-pull paradigm and recorded the hand kinematics as well as eight surface EMGs. Subjects had to either perform a precision grip or side grip and had to modify their grip force in order to displace an object against a low or high load. The analysis was subdivided into three epochs: reach, grasp-and-pull, and static hold. Principal component analysis (PCA, temporal or static) was performed separately for all three epochs, in the kinematic and in the EMG domain. PCA revealed that (i) Kinematic-and muscle-synergies can simultaneously accommodate kinematic (grip type) and kinetic task constraints (load condition). (ii) Upcoming grip and load conditions of the grasp are represented in kinematic-and muscle-synergies already during reach. Phase plane plots of the principal muscle-synergy against the principal kinematic synergy revealed (iii) that the muscle-synergy is linked (correlated, and in phase advance) to the kinematic synergy during reach and during grasp-and-pull. Furthermore (iv), pair-wise correlations of EMGs during hold suggest that muscle-synergies are (in part) implemented by coactivation of muscles through common input. Together, these results suggest that kinematic synergies have (at least in part) their origin not just in muscular activation, but in synergistic muscle activation. In short: kinematic synergies may result from muscle synergies.
Published: 2015
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41. Identification and validation of biomarkers for autism spectrum disorders

Author: Marion Haberkamp, Karl Broich, Sarah Durston, Antonio M. Persico, Luca Pani, Tony Charman, Michael V. Lombardo, Luke Mason, Sven Bölte, Declan G. Murphy, Christine Ecker, Simon Baron-Cohen, Koichi Okamoto, Emily J.H. Jones, Jordi Llinares-Garcia, Steve C.R. Williams, Lindsay Ham, Will Spooren, Spiros Vamvakas, David A. Collier, Emily Simonoff, Caroline Auriche-Benichou, Maria Isaac, Thomas Bourgeron, Valentina Mantua, Sabine Lenton, Andreas Meyer-Lindenberg, Robert Hemmings, Sitra Tauscher-Wisniewski, Mark H. Johnson, Eva Loth, Jan K. Buitelaar, Omar Khwaja, Andre Elferink, Gahan Pandina, Tobias Banaschewski, Laurence O'Dwyer, Fernando de Andres-Trelles, Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], European Medicines Agency [London] (EMA), Agence nationale de sécurité du médicament et des produits de santé [Saint-Denis] (ANSM), Medizinische Fakultät Mannheim, Universität Heidelberg [Heidelberg] = Heidelberg University, University of Cambridge [UK] (CAM), Federal Institute of Drugs and Medical Devices [Bonn], Karolinska Institutet [Stockholm], Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Eli Lilly and Company Limited [Windlesham], Spanish Medicines Agency and Medical Devices [Madrid] (AEMPS), University Medical Center [Utrecht], Medicines Evaluation Board [Utrecht], Centre for Brain and Cognitive Development [Birkbeck College], Birkbeck College [University of London], Italian Medicines Agency [Roma] (AIFA), University of Cyprus [Nicosia] (UCY), Radboud University Medical Center [Nijmegen], Janssen Research & Development, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Universität Heidelberg [Heidelberg], Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), and University of Cyprus [Nicosia]
Subjects: Male, Autism Spectrum Disorder, [SDV]Life Sciences [q-bio], [SCCO]Cognitive science, 0302 clinical medicine, MESH: Child, Drug Discovery, Child, ComputingMilieux_MISCELLANEOUS, MESH: Autism Spectrum Disorder, Medicine (all), 05 social sciences, MESH: Endophenotypes, General Medicine, Autism spectrum disorders, Gene expression profiling, MESH: Reproducibility of Results, Autism spectrum disorder, MESH: Young Adult, Child, Preschool, Female, Identification (biology), 050104 developmental & child psychology, Adult, medicine.medical_specialty, Adolescent, Endophenotypes, Brain imaging, Computational biology, Young Adult, 03 medical and health sciences, Neuroimaging, medicine, Humans, 0501 psychology and cognitive sciences, Preschool, Psychiatry, Pharmacology, MESH: Adolescent, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, Drug Discovery3003 Pharmaceutical Science, MESH: Child, Preschool, Reproducibility of Results, MESH: Adult, medicine.disease, MESH: Male, Adolescent, Adult, Autism Spectrum Disorder, Biomarkers, Child, Child, Preschool, Endophenotypes, Female, Humans, Male, Reproducibility of Results, Young Adult, Medicine (all), Pharmacology, Drug Discovery3003 Pharmaceutical Science, Biomarkers, Endophenotype, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, MESH: Biomarkers, Autism, business, MESH: Female, 030217 neurology & neurosurgery
Abstract: Item does not contain fulltext
Published: 2015
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42. Universal natural shapes: From unifying shape description to simple methods for shape analysis and boundary value problems

Author: Ilia Tavkelidze, Johan Gielis, Yohan Fougerolle, Tom Gerats, Diego Caratelli, P. E. Ricci, genicap, Radboud university [Nijmegen], Institute for Wetland and Water Research, Department Biosciences Engineering, Antwerp, International Research Centre for Telecommunications and Radar, International Research Centre for Telecommunications and Radar [Delft], Delft University of Technology (TU Delft)-Delft University of Technology (TU Delft), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Campus Bio-Medico University, Rome, Italy, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), I. Vekua Institute of Applied Mathematics, I. Javakhishvili Tbilisi State University, Delft University of Technology ( TU Delft ) -Delft University of Technology ( TU Delft ), Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Campus Bio-Medico University, and University of Rome-University of Rome
Subjects: Evolutionary algorithm, lcsh:Medicine, Geometry, Bioinformatics, Curvature, [ INFO.INFO-CV ] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Plant Genetics, 01 natural sciences, 03 medical and health sciences, symbols.namesake, [ MATH.MATH-AP ] Mathematics [math]/Analysis of PDEs [math.AP], Non-Euclidean geometry, Applied mathematics, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Boundary value problem, Bounday Value Problem, 0101 mathematics, lcsh:Science, Biology, Mathematical Computing, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 030304 developmental biology, Laplace's equation, Physics, Dirichlet problem, 0303 health sciences, Multidisciplinary, Applied Mathematics, lcsh:R, 010102 general mathematics, Computational Biology, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Laplace equation, Models, Theoretical, Gielis Curves, Fourier analysis, Computer Science, symbols, lcsh:Q, Engineering sciences. Technology, Algorithms, Mathematics, Shape analysis (digital geometry), Research Article, Developmental Biology, Computer Modeling
Abstract: Gielis curves and surfaces can describe a wide range of natural shapes and they have been used in various studies in biology and physics as descriptive tool. This has stimulated the generalization of widely used computational methods. Here we show that proper normalization of the Levenberg-Marquardt algorithm allows for efficient and robust reconstruction of Gielis curves, including self-intersecting and asymmetric curves, without increasing the overall complexity of the algorithm. Then, we show how complex curves of k-type can be constructed and how solutions to the Dirichlet problem for the Laplace equation on these complex domains can be derived using a semi-Fourier method. In all three methods, descriptive and computational power and efficiency is obtained in a surprisingly simple way. Formal Correction: see "host".
Published: 2012
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43. Development on an implantable system for relieving phantom pain using transversal intrafascicular electrodes

Author: Stieglitz, Thomas, Boretius, Tim, Navarro, Xavier, Badia, Jordi, Guiraud, David, Divoux, Jean-Louis, Micera, Silvestro, Maria Rossini, Paolo, Yoshida, Ken, Jensen, Winnie, Department of Microsystems Engineering [Freiburg] (IMTEK), University of Freiburg [Freiburg], Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona (UAB), Artificial movement and gait restoration (DEMAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), AXONIC - OBELIA dept, MXM-Laboratoires de Techologies Médicales, Scuela Santa Anna (SSSA), Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Biomedical Robotics and Biomicrosystems Lab - UCBM, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, Center for Sensory-Motor Interaction (SMI), Aalborg University [Denmark] (AAU), European Project: 224012,EC:FP7:ICT,FP7-ICT-2007-2,TIME(2008), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM)
Subjects: [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics
Abstract: International audience; Phantom limb pain develops in the majority of amputees. The underlying mechanisms are not yet com- pletely understood and thus, no treatment is fully effective. Based on recent studies with electrical stimu- lation, we hypothesize that electrical stimulation of afferent nerves with a sufficiently high spatial resolu- tion might alleviate phantom limb pain by giving sensory input to the patient. We present our system con- cepts in general and focus here on a novel electrode concept to selectively interface small nerve fiber ensembles on the fascicular level over the complete cross section of a peripheral nerve: the transversal intrafascicular multichannel nerve electrode (TIME). Electrodes have been developed supported by elec- trical and mechanical simulations of the interface and evaluated with respect to their functional selectivity on peripheral nerves in two animal models.
Published: 2011

44. Development of an implantable transverse intrafascicular multichannel electrode (TIME) system for relieving phantom limb pain

Author: Silvestro Micera, Paolo Maria Rossini, Ken Yoshida, David Guiraud, Winnie Jensen, Thomas Stieglitz, Xavier Navarro, Jean-Louis Divoux, Center for Sensory-Motor Interaction (SMI), Aalborg University [Denmark] (AAU), Scuela Santa Anna (SSSA), Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Cell Biology, Physiology and Immunology, Department of Microsystems Engineering [Freiburg] (IMTEK), University of Freiburg [Freiburg], Artificial movement and gait restoration (DEMAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), AXONIC - OBELIA dept, MXM-Laboratoires de Techologies Médicales, Biomedical Robotics and Biomicrosystems Lab - UCBM, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, European Project: 224012,EC:FP7:ICT,FP7-ICT-2007-2,TIME(2008), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM)
Subjects: multichannel microstimulation, medicine.medical_treatment, Finite Element Analysis, Phantom limb, Pain, human machine interface, phantoms, Electric Stimulation Therapy, Phantom limb pain, 03 medical and health sciences, 0302 clinical medicine, Neuromuscular stimulation, Amputees, user interfaces, Animals, Humans, Pain Management, Medicine, Microstimulation, Effective treatment, Peripheral Nerves, prosthetics, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, 030304 developmental biology, 0303 health sciences, business.industry, Time system, medicine.disease, equipment and supplies, nerve stump, Electric Stimulation, Electrodes, Implanted, Rats, neuromuscular stimulation, body regions, implantable transverse intrafascicular multichannel electrode system, phantom limb pain, Phantom Limb, Amputation, biomedical electrodes, Human–machine interface, business, 030217 neurology & neurosurgery, Biomedical engineering
Abstract: International audience; Phantom limb pain frequently follows amputation. Currently there is no fully effective treatment available. Our aim is to develop an innovative Human Machine Interface (HMI) where we apply multi-channel microstimulation to the nerve stump of an amputee subject to manipulate the phantom limb sensations and explore the possibility of using microstimulation as a treatment for phantom limb pain.
Published: 2010
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45. Transverse Intrafascicular Multichannel Electrode (TIME) System for Treatment of Phantom Limb Pain in Amputees

Author: Winnie Jensen, Micera, S., Navarro, X., Stieglitz, T., Guiraud, D., Divoux, J., Rossini, P. M., Ken Yoshida, Center for Sensory-Motor Interaction (SMI), Aalborg University [Denmark] (AAU), Scuela Santa Anna (SSSA), Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Universitat Autònoma de Barcelona (UAB), Department of Microsystems Engineering [Freiburg] (IMTEK), University of Freiburg [Freiburg], Artificial movement and gait restoration (DEMAR), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), AXONIC - OBELIA dept, MXM-Laboratoires de Techologies Médicales, Biomedical Robotics and Biomicrosystems Lab - UCBM, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, Falla, Deborah, Farina, Dario, Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), and Guiraud, David
Subjects: [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], [SPI.AUTO] Engineering Sciences [physics]/Automatic, [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], électrode intrafasciculaire, Physiologie, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract: International audience; AIM: Phantom limb pain (PLP) develops in the lost limb in 50-80% of amputees. Today, it is not completely understood why the pain occurs, and no effective treatments are available. The favorable effect of electrical stimulation on PLP has been demonstrated. Our aim is to develop a novel system for manipulation of sensations by application of multi-channel microstimulation to the nerve stump of an amputee and explore this method as a treatment for clinched fist PLP (see figure). RESULTS: 1) Electrode design. Non-corrugated TIME electrodes with different dimensions and 8-12 active sites have been manufactued and tested in vivo and in vitro testing in the rat and pig. Methods for corrugated prototypes were developed and the first prototypes were realized. 2) Electrode selectivity modeling. A peripheral nerve model is under development to evaluate the electrode's selective stimulation properties and to optimize electrode design. Simulated currents and neural activity generated were qualitatively assessed using experimental data obtained from rat nerves. 3) Implant modeling. To optimize the implantation procedure, a theoretical peripheral nervous tissue model and a 3D FEM was implemented. Both models closely reproduce the experimental peripheral nervous tissue behaviour and simulate the insertion forces transmitted to the electrode during implantation. 4) Multi-channel stimulators and connectors. A 12-pole prototype, bench-top stimulator has been implemented and successfully tested in animal experiments. A high-count, implantable connector between stimulator and electrode has been designed. 5) Biocompatibility. Electrode materials were evaluated and did not induce immune rejection and significant inflammatory reaction after in vivo implantation in the rat. Electrode implantation will require an understanding of the fascicular characteristics of the target nerve. Morphological characteristics of the rat, pig and human nerves are currently evaluated and compared. 6) Animal testing. First TIME electrodes test were carried out in the acute rat and acute pig. Results indicated selective stimulation of different fascicles with graded recruitment. 7) Clinical evaluation: To quantify the location of artificially evoked sensations and evaluate the strength of artificially evoked sensations a psychophysical testing platform is under development. Main inclusion criteria for patient recruitment have been identified and protocols have been defined. CONCLUSION: The feasibility of the corrugated version of the TIME electrode has yet to be explored. Further work designing, optimizing and testing the TIME electrode and all technological developments will be carried out including theoretical stimulations and animal experimental work before the optimal electrode for human implant will be chosen.
Published: 2010

46. Contradiction in universal and particular reasoning

Author: Camillo Porcaro, Franca Tecchio, Stefano Seri, Maria Teresa Medaglia, Paolo Maria Rossini, Giorgio Di Lorenzo, Philosophy Department, Roma Tre University, ISTC, Consiglio Nazionale delle Ricerche (CNR), Casa di Cura SAN RAFFAELE Cassino e IRCCS SAN RAFFAELE PISANA, The Wellcome Trust Laboratory for MEG Studies, School of Life and Health Sciences, Aston University [Birmingham], Laboratory of Psychophysiology, Psychiatric Clinic, Department of Neuroscience, Università degli Studi di Roma Tor Vergata [Roma], Clinical Neurology, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), School of Psychology and Birmingham University Imaging Centre (BUIC), University of Alabama at Birmingham [ Birmingham] (UAB), Fatebenefratelli Hospital, Isola Tiberina, AFaR, Institute for Advanced Biomedical Technologies, and Institut Technique de l'Agriculture Biologique (ITAB)
Subjects: Male, Signal Processing, Computer-Assisted, Humans, Electroencephalography, Algorithms, Brain, Cognition, Intelligence, Brain Mapping, Reward, Adult, Neural Pathways, Female, Phase locking, Contradictory reasoning, 0302 clinical medicine, Computer-Assisted, Contradiction, Electroencephalography (EEG), Independent component analysis (ICA), Logical operators, Research Articles, media_common, Radiological and Ultrasound Technology, medicine.diagnostic_test, 05 social sciences, Life Sciences, Neurology, Anatomy, Psychology, Sentence, Cognitive psychology, media_common.quotation_subject, Rationality, 050105 experimental psychology, 03 medical and health sciences, Reward system, medicine, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Settore MED/25 - Psichiatria, Communication, business.industry, Signal Processing, Neurology (clinical), business, 030217 neurology & neurosurgery, Counterexample
Abstract: A wide range of essential reasoning tasks rely on contradiction identification, a cornerstone of human rationality, communication and debate founded on the inversion of the logical operators “Every” and “Some.” A high‐density electroencephalographic (EEG) study was performed in 11 normal young adults. The cerebral network involved in the identification of contradiction included the orbito‐frontal and anterior‐cingulate cortices and the temporo‐polar cortices. The event‐related dynamic of this network showed an early negative deflection lasting 500 ms after sentence presentation. This was followed by a positive deflection lasting 1.5 s, which was different for the two logical operators. A lesser degree of network activation (either in neuron number or their level of phase locking or both) occurred while processing statements with “Some,” suggesting that this was a relatively simpler scenario with one example to be figured out, instead of the many examples or the absence of a counterexample searched for while processing statements with “Every.” A self‐generated reward system seemed to resonate the recruited circuitry when the contradictory task is successfully completed. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
Published: 2009
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47. Effect of autochthonous lactic acid bacteria starters on health-promoting and sensory properties of tomato juices

Author: Rosalinda F. Surico, Marco Gobbetti, Jean-Christophe Salmon, Raffaella Di Cagno, Maria De Angelis, Laura De Gara, Solange Buchin, Annalisa Paradiso, Università degli Studi di Bari Aldo Moro, Unité de recherches en Technologie et Analyses Laitières (URTAL), Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, and Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM)
Subjects: Time Factors, Food Handling, Colony Count, Microbial, Microbiology, AUTOCHTHONUS LACTIC ACID BACTERIA, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, Solanum lycopersicum, Food Preservation, RNA, Ribosomal, 16S, Food microbiology, Humans, TOMATO JUICE, COLOR, Weissella cibaria, ANTIOXYDANTS, 2. Zero hunger, 0303 health sciences, Principal Component Analysis, biology, 030306 microbiology, Lactobacillus brevis, Temperature, food and beverages, 04 agricultural and veterinary sciences, General Medicine, Consumer Behavior, biology.organism_classification, Ascorbic acid, 040401 food science, Lactic acid, Random Amplified Polymorphic DNA Technique, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, chemistry, Consumer Product Safety, Lactobacillaceae, Taste, Fermentation, Food Microbiology, Pediococcus, Food, Organic, Volatilization, Lactobacillus plantarum, Food Science, FLAVOR
Abstract: Publication Inra prise en compte dans l'analyse bibliométrique des publications scientifiques mondiales sur les Fruits, les Légumes et la Pomme de terre. Période 2000-2012. http://prodinra.inra.fr/record/256699; International audience; Strains of Lactobacillus plantarum, Weissella cibaria/confusa, Lactobacillus brevis, Pediococcus pentosaceous, Lactobacillus sp. and Enterococcus faecium/faecalis were identified from raw tomatoes by Biolog System, partial 16S rRNA gene sequence and subjected to typing by Random Amplified Polymorphic DNA-Polymerase Chain Reaction (RAPD-PCR) analysis. Ten autochthonous strains were singly used to ferment tomato juice (TJ) via a protocol which included fermentation at 25 °C for 17 h and further storage at 4 °C for 40 days. Unstarted TJ and TJ fermented with an allochthonous strain of L. plantarum were used as the controls. All autochthonous strains grew well in TJ reaching cell densities ca. 10,000 and 10 times higher than unstarted TJ and TJ fermented with the allochthonous strain. Viscosity of TJs fermented with autochthonous strains was generally the highest, especially when started with W. cibaria/confusa which synthesized exo-polysaccharides. Overall, unstarted TJ and TJ fermented with the allochthonous strain showed marked decreases of ascorbic acid (ASC), glutathione (GSH) and total antioxidant activity (TTA) during storage. On the contrary, several TJs fermented with autochthonous strains, especially with L. plantarum POM1 and POM 35, maintained elevated values of ASC, GSH and TAA. The variation of color indexes mirrored the above behavior. TJs fermented with the above two autochthonous strains were compared to controls based on volatile components through Purge and Trap or Solid Phase Microextraction Gas Chromatography-Mass Spectrometry (PT or SPME-GC/MS) analysis. As shown by Principal Component Analysis a large number of volatiles belonging to various chemical classes markedly differentiated TJs fermented with autochthonous strains with respect to controls.
Published: 2009
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48. A case of primary MALT lymphoma of the endometrium presenting as an asymptomatic polyp

Author: Francesco Marchesi, M.C. Tirindelli, Aa Romeo, Ombretta Annibali, Claudio Agostinelli, Stefano Pileri, M. De Muro, Giuseppe Avvisati, Annalisa Natale, Department of Hematology, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Section of Hematopathology, Department of Hematology and Oncology, L. and A. Seràgnoli, S. Orsola-Malpighi Hospital, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), University Chieti-Pescara, Annibali O, Romeo AA, Agostinelli C, Marchesi F, Natale A, De Muro M, Tirindelli MC, Pileri SA, and Avvisati G.
Subjects: Pathology, medicine.medical_specialty, Population, Biology, Endometrium, 03 medical and health sciences, 0302 clinical medicine, medicine, Endometrial Polyp, Centroblasts, education, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, education.field_of_study, Germinal center, MALT lymphoma, Hematology, General Medicine, Marginal zone, medicine.disease, 3. Good health, medicine.anatomical_structure, Lymphatic system, 030220 oncology & carcinogenesis, Medicine
Abstract: Dear Editor,Herein, we present the case of an 81-year-old Caucasianwoman who received a diagnosis of breast cancer in March2006. During staging procedures, a transvaginal echogra-phy revealed an endometrial polyp that was removed a fewmonths later, after the completion of the breast cancertherapeutic program.At microscopic examination, the polyp was character-ized by numerous cystically dilated glands, mainly locatedat its periphery (Fig. 1). The stalk was diffusely infiltratedby a lymphomatous population consisting of small-sizedelements with slightly indented nuclei, moderately dis-persed chromatin, inconspicuous nucleoli, and a narrow rimof clear cytoplasm (Fig. 1). Such population tended tofocally invade the glandular component giving rise tolymphoepithelial lesions and to colonize and substitutepreexisting germinal centers. As a consequence of the latterevent, a few centroblasts were scattered throughout theneoplastic growth. At immunohistochemistry, the lympho-matous population expressed the B-cell markers CD20 andCD79a, as well as the marginal zone-associated moleculeimmune receptor translocation associated 1 (IRTA1; Fig. 1).In the areas corresponding to germinal center colonization,neoplastic cells—always CD10 negative—showed faintpositivity for Bcl-6, in contrast to residual germinal centerB-cells that strongly expressed both Bcl-6 and CD10 (Fig.1). The Ki-67 marking accounted for less than 5% of thewhole neoplastic population (Fig. 1). Based on thesefindings, a diagnosis of extranodal marginal zone B-celllymphoma of mucosa-associated lymphoid tissue (MALTlymphoma) arising in an endometrial polyp was made.Fever, night sweating, loss of weight, and local signs orsymptoms were absent at diagnosis. The blood cell countrevealed only a mild normocytic and normochromic anemiaassociated with a mild increase of erythrocyte sedimenta-tion rate. Serum
Published: 2008
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49. Multisensory bionic limb to achieve prosthesis embodiment and reduce distorted phantom limb perceptions

Author: Giuseppe Granata, David Guiraud, Andrea Serino, Giulio Rognini, Francesco Maria Petrini, Olaf Blanke, Robin Mange, Marco Solcà, Edoardo D'Anna, Giacomo Valle, Giovanni Di Pino, Ivo Strauss, Javier Bello-Ruiz, Paolo Maria Rossini, David Andreu, Bruno Herbelin, Silvestro Micera, Riccardo Di Iorio, Thomas Stieglitz, Stanisa Raspopovic, Center for Neuroprosthetics [Geneva] (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory of Cognitive Neuroscience (LNCO), School of Engineering STI [Lausanne], Department of Health Sciences and Technology [ETH Zürich] (D-HEST), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Scuola Universitaria Superiore Sant'Anna [Pisa] (SSSUP), Università cattolica del Sacro Cuore [Roma] (Unicatt), Biomedical Robotics and Biomicrosystems Lab - UCBM, Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Department of Microsystems Engineering [Freiburg] (IMTEK), University of Freiburg [Freiburg], Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM)
Subjects: Bionics, medicine.medical_specialty, Neuroprosthetics, medicine.medical_treatment, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Phantom limb, Artificial Limbs, consciousness, Prosthesis, Article, Imaging phantom, [SPI.AUTO]Engineering Sciences [physics]/Automatic, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Forearm, Feedback, Sensory, Surveys and Questionnaires, Sensation, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, electrical stimulation, Ulnar nerve, business.industry, medicine.disease, body regions, Psychiatry and Mental health, medicine.anatomical_structure, Phantom Limb, Upper limb, Surgery, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract: A major goal of neuroprosthetics is to design artificial limbs that are experienced (‘embodied’) like real limbs. However, despite important technological advances, this goal has not been reached and prosthesis embodiment is still very limited. Differently from our physical body, current bionic limbs do not provide the continuous multisensory feedback required for a limb to be experienced as one’s own. Here, we present a novel neuroprosthetic approach that combines peripheral neurotactile stimulation—inducing tactile sensation on the missing limb—and immersive digital technology—providing visual illumination of the prosthetic hand. We tested whether coherent multisensory visuo-tactile neural stimulation (VTNS)1 induced higher prosthesis embodiment and reduced the distorted perception of the phantom limb (telescoping, ie, the phantom limb is perceived as shorter than the intact limb). Patient 1 and patient 2 are transradial left forearm chronic amputees, who suffered upper limb telescoping. Patients were implanted with transverse intrafascicular multichannel electrodes (TIMEs), which induced the sensation of a vibration in a circumscribed skin region of the finger 2 via medial nerve stimulation in patient 1 (online supplementary figure 1A) and in a skin region of finger 5 via ulnar nerve stimulation in patient 2 (online supplementary figure 1B and material 1). Neurotactile stimulation2 was coupled with automatised visual illumination of a skin region on the patient’s prosthetic hand that corresponded to the somatotopic location of touch sensations experienced on the phantom hand (VTNS; online supplementary video 1, online supplementary figure 1, online supplementary material 1). VTNS was administered in two conditions, either with synchronous visual and neurotactile stimulation or in a control condition of asynchronous stimulation (1.5–2.5s delay). ### Supplementary data [jnnp-2018-318570-supp1.pdf] ### Supplementary video [jnnp-2018-318570-supp1.mp4] Prosthesis embodiment was measured via a questionnaire, whereas changes in phantom limb perception were tested via a body landmark task where patients indicated the perceived position of different parts of the phantom limb …
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50. Observation of universal Hall Response in strongly interacting fermions

Author: Zhou, T., Tusi, D., Lorenzo Franchi, Filippone, M., Repellin, C., Greschner, S., Jacopo Parravicini, Massimo Inguscio, Cappellini, G., Catani, J., Giamarchi, T., Leonardo Fallani, Università degli Studi di Firenze = University of Florence (UniFI), Istituto Nazionale di Ottica [Firenze] (INO-CNR), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), European Laboratory for Non-Linear Spectroscopy (LENS), Laboratoire de physique et modélisation des milieux condensés (LPM2C ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Department of Quantum Matter Physics [Geneva] (DQMP), Université de Genève = University of Geneva (UNIGE), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), Department of Engineering Science, Guglielmo Marconi University [Roma], Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: Quantum Physics, condensed matter, [PHYS.COND.GAS]Physics [physics]/Condensed Matter [cond-mat]/Quantum Gases [cond-mat.quant-gas], Strongly Correlated Electrons (cond-mat.str-el), Hall effect, quenching, FOS: Physical sciences, magnetic field, tracks, charged particle, low, topological, Condensed Matter - Strongly Correlated Electrons, tunneling, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], Quantum Gases (cond-mat.quant-gas), [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], [PHYS.COND.CM-SCE]Physics [physics]/Condensed Matter [cond-mat]/Strongly Correlated Electrons [cond-mat.str-el], Condensed Matter - Quantum Gases, Quantum Physics (quant-ph)
Abstract: The Hall effect, originating from the motion of charged particles in magnetic fields, has deep consequences for the description of materials, extending far beyond condensed matter. Understanding such an effect in interacting systems represents a fundamental challenge, even for small magnetic fields. Here we use an atomic quantum simulator where we track the motion of ultracold fermions in two-leg ribbons threaded by artificial magnetic fields. Through controllable quench dynamics, we measure the Hall response for a range of synthetic tunneling and atomic interaction strength. We unveil a universal interaction-independent behavior above an interaction threshold, in agreement with theoretical analyses. Our system, able to reach hard to compute regimes also demonstrates the power of quantum simulation for strongly correlated topological states of matter., Comment: 14 pages, 12 figures

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