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405 results on '"Università degli Studi di Modena e Reggio Emilia (UNIMORE)"'

1. First-in-human Study to Examine Safety of a New Peritoneal Dialysis Device (WEAKID) in End-stage Kidney Disease Patients (CORDIAL)

Author: European Commission, Horizon 2020, Dutch Kidney Foundation, Health Holland, Nanodialysis Ltd, Università degli studi di Modena e Reggio Emilia (UNIMORE), Servicio Madrileno De Salud (SERMAS), PPI Healthcare Consulting Ltd, and K.G.F. Gerritsen, MD, PhD, Associate professor
Published: 2024

2. Arc flow formulations based on dynamic programming: Theoretical foundations and applications

Author: Cláudio Alves, François Clautiaux, José Manuel Valério de Carvalho, Manuel Iori, Vinícius Loti de Lima, Institute of Computing [Campinas] (IC), Universidade Estadual de Campinas = University of Campinas (UNICAMP), Universidade do Minho = University of Minho [Braga], Formulations étendues et méthodes de décomposition pour des problèmes génériques d'optimisation (EDGE), Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), The ﬁrst and fourth authors have been supported by FAPESP - Funda¸cao de Amparo a Pesquisa do Estado de Sao Paulo (under grant numbers 2017/11831-1 and 2019/12728-5). The second and the ﬁfth authors have been supported by FCT - Funda¸cao para a Ciencia e Tecnologia within the R&D Units Project Scope: UIDB/00319/2020., Institute of Computing [Campinas] (UNICAMP), Universidade Estadual de Campinas (UNICAMP), Universidade do Minho, Reformulations based algorithms for Combinatorial Optimization (Realopt), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, and Università degli Studi di Modena e Reggio Emilia (UNIMORE)
Subjects: FOS: Computer and information sciences, Mathematical optimization, Combinatorial optimization, Dynamic Programming, Information Systems and Management, Optimization problem, General Computer Science, Computer science, Other Computer Science (cs.OH), 0211 other engineering and technologies, 02 engineering and technology, Management Science and Operations Research, Dynamic programming, Pseudo-Polynomial, Industrial and Manufacturing Engineering, Arc (geometry), Computer Science - Other Computer Science, Combinatorial Optimization, 0502 economics and business, FOS: Mathematics, Mathematics - Optimization and Control, Integer programming, 050210 logistics & transportation, Acyclic Network, 021103 operations research, Arc flow, 05 social sciences, Relaxation (iterative method), [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], Solver, Acyclic network, Pseudo-polynomial, Flow network, Flow (mathematics), Optimization and Control (math.OC), Modeling and Simulation, Arc Flow
Abstract: Network flow formulations are among the most successful tools to solve optimization problems. Such formulations correspond to determining an optimal flow in a network. One particular class of network flow formulations is the arc flow, where variables represent flows on individual arcs of the network. For N P -hard problems, polynomial-sized arc flow models typically provide weak linear relaxations and may have too much symmetry to be efficient in practice. Instead, arc flow models with a pseudo-polynomial size usually provide strong relaxations and are efficient in practice. The interest in pseudo-polynomial arc flow formulations has grown considerably in the last twenty years, in which they have been used to solve many open instances of hard problems. A remarkable advantage of pseudo-polynomial arc flow models is the possibility to solve practical-sized instances directly by a Mixed Integer Linear Programming solver, avoiding the implementation of complex methods based on column generation. In this survey, we present theoretical foundations of pseudo-polynomial arc flow formulations, by showing a relation between their network and Dynamic Programming (DP). This relation allows a better understanding of the strength of these formulations, through a link with models obtained by Dantzig-Wolfe decomposition. The relation with DP also allows a new perspective to relate state-space relaxation methods for DP with arc flow models. We also present a dual point of view to contrast the linear relaxation of arc flow models with that of models based on paths and cycles. To conclude, we review the main solution methods and applications of arc flow models based on DP in several domains such as cutting, packing, scheduling, and routing.
Published: 2022

3. Occurrence and characterization of tremolite asbestos from the Mid Atlantic Ridge

Author: Di Giuseppe, Dario, Perchiazzi, Natale, Brunelli, Daniele, Giovanardi, Tommaso, Nodari, Luca, Della Ventura, Giancarlo, Malferrari, Daniele, Maia, Marcia, Gualtieri, Alessandro, Laboratoire Géosciences Océan (LGO), Institut Français de Recherche pour l'Exploitation de la Mer - Brest (IFREMER Centre de Bretagne), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Interdisciplinary Graduate School for the Blue planeT, ANR-17-EURE-0015,ISBlue,Interdisciplinary Graduate School for the Blue planet(2017), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Di Giuseppe, D., Perchiazzi, N., Brunelli, D., Giovanardi, T., Nodari, L., Della Ventura, G., Malferrari, D., Maia, M., and Gualtieri, A. F.
Subjects: STRUCTURAL-CHARACTERIZATION, Solid Earth sciences, Science, Mineralogy, Article, SHORT-RANGE ORDER, [SDU]Sciences of the Universe [physics], [SDE]Environmental Sciences, Medicine, ROMANCHE FRACTURE-ZONE, Tremolite, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; Tremolite is one of the most common amphibole species and, in the fibrous form (i.e., characterized by crystals/particles consisting of fibres with length > 5 µm, width 3), one of the six asbestos minerals. Until now the attention of crystallographers has focused only on samples from continental environment. Here we report the first chemical and structural data of a tremolite asbestos found along the Mid Atlantic Ridge (MAR) at the eastern intersection of the Romanche Transform Fault (Equatorial MAR). Tremolite is associated with chlorite and lizardite and was formed through the green shale facies lower than zeolite in a predominantly fluid system. MAR tremolite asbestos shows very slight deviations from the ideal crystal structure of tremolite. Differences in cation site partitioning were found with respect to tremolite asbestos from ophiolitic complexes, attributed to the different chemical–physical conditions during the mineral formation. In particular, oceanic tremolite asbestos is enriched in Al and Na, forming a trend clearly distinct from the continental tremolites.
Published: 2021

4. Analysis of Resonant Soft X-ray Reflectivity of Anisotropic Layered Materials

Author: Angelo Giglia, Raffaella Capelli, Matteo Bonfatti, Lorenzo Sponza, Emanuele Galligani, Adriano Verna, Luca Pasquali, Nicola Mahne, Stefano Nannarone, Francesco Mezzadri, Università degli Studi di Modena e Reggio Emilia (UNIMORE), CNR Istituto Officina dei Materiali (IOM), Consiglio Nazionale delle Ricerche [Roma] (CNR), University of Johannesburg (UJ), Università degli Studi Roma Tre, LEM, UMR 104, CNRS-ONERA, Université Paris-Saclay (Laboratoire d'étude des microstructures), ONERA-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Pasquali, L, Mahne, N, Giglia, A, Verna, A, Sponza, L, Capelli, R, Bonfatti, M, Mezzadri, F, Galligani, E, and Nannarone, S
Subjects: [PHYS]Physics [physics], Materials science, Condensed matter physics, Physics, QC1-999, organic thin films, Electronic structure, 010502 geochemistry & geophysics, 01 natural sciences, Reflectivity, anisotropic optical propertie, soft X-ray reflectivity, [SPI]Engineering Sciences [physics], Orientation (geometry), 0103 physical sciences, anisotropic optical properties, [CHIM]Chemical Sciences, Molecule, Specular reflection, Thin film, 010306 general physics, Absorption (electromagnetic radiation), Anisotropy, 0105 earth and related environmental sciences
Abstract: We present here a method for the quantitative prediction of the spectroscopic specular reflectivity line-shape in anisotropic layered media. The method is based on a 4 &times, 4 matrix formalism and on the simulation from the first principles (through density functional theory&mdash, DFT) of the anisotropic absorption cross-section. The approach was used to simulate the reflectivity at the oxygen K-edge of a 3,4,9,10-perylene-tetracarboxylic dianhydride (PTCDA) thin film on Au(111). The effect of film thickness, orientation of the molecules, and grazing incidence angle were considered. The simulation results were compared to the experiment, permitting us to derive information on the film geometry, thickness, and morphology, as well as the electronic structure.
Published: 2021

5. Synthesis and characterization of polymethine dyes carrying thiobarbituric and carboxylic acid moieties

Author: Arthur Desvals, Mariagrazia Fortino, Corentin Lefebvre, Johann Rogier, Clément Michelin, Samy Alioui, Elodie Rousset, Alfonso Pedone, Gilles Lemercier, Norbert Hoffmann, Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Institut de Chimie de Clermont-Ferrand (ICCF), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE)
Subjects: [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, polymethine dyes, Materials Chemistry, [CHIM]Chemical Sciences, General Chemistry, DFT, Catalysis, Spectroscopy, DFT, polymethine dyes
Abstract: International audience; An efficient synthesis of polymethine dyes carrying thiobarbituric and a carboxylic acid moiety has been developed. Such compounds play a key role in many photometric detections and quantifications of enzyme activities. In such tests, the metabolite of the enzyme activities is transformed into a β-dicarbonyl derivative. In the present study, this compound was prepared from furfural through organic synthesis. Its in situ transformation with thiobarbituric acid derivatives yields the target compounds on a gram-scale (0.4 to 0.6 g). A combined experimental and theoretical study of the photophysical properties of the synthesized compounds was carried out. Absorption and emission spectroscopy measurements highlighted a slight solvatochromism effect. The luminescence was quenched by molecular oxygen, indicating the partial triplet multiplicity character of the lowest excited state. Density Functional Theory (DFT) calculations have been applied for the evaluation of favoured conformations for these new compounds and the study of their optical properties. Within the Franck Condon principle, vibrationally resolved electronic one-photon absorption spectrum has been simulated. This simulation shows the presence of a major band followed by a vibronic sideband, typical of organic chromophores in solution. The performed computational study revealed that the transition from the ground to the first excited electronic state has a π-π* character. Finally, TD-DFT energy level diagram calculations highlighted the presence of triplet states very close to the first singlet excited one, suggesting probable access to the triplet-excited state.
Published: 2022

6. Assessor burden, inter-rater agreement and user experience of the RoB-SPEO tool for assessing risk of bias in studies estimating prevalence of exposure to occupational risk factors

Author: Liliane Reis Teixeira, Daniele Mandrioli, Kathrine Sørensen, Lode Godderis, Daniela Pachito, Kai N. Streicher, Tom Loney, Daria Sgargi, Vivi Schlünssen, Diana Gagliardi, Paul T.J. Scheepers, Alberto Modenese, Grace Sembajwe, Alexis Descatha, Frank Pega, Denise Torres da Silva, Thomas Tenkate, Rebecca L. Morgan, Natalie C. Momen, Marília Silva Paulo, Monique H. W. Frings-Dresen, WHO-TDR Suisse, Escola Nacional de Saude Publica Sergio Arouca / Sergio Arouca National School of Public Health [Rio de Janeiro] (ENSP), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Service de médecine physique et de réadaptation [ CHU Raymond-Poincaré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Amsterdam UMC, Istituto Nazionale per l’Assicurazione contro gli Infortuni sul Lavoro [Italian Workers Compensation Authority] (INAIL), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Università degli Studi di Modena e Reggio Emilia (UNIMORE), McMaster University [Hamilton, Ontario], Fundacao Getulio Vargas [Rio de Janeiro] (FGV), Radboud University Medical Center [Nijmegen], United Arab Emirates University (UAEU), Aarhus University [Aarhus], City University of New York [New York] (CUNY), Ryerson University [Toronto], World Health Organization from National Institute for Occupational Safety and Health of the Centres for Disease Control and Prevention of the United States of America [1E11OH0010676-02, 6NE11OH010461-02-01, 5NE11OH010461-03-00], German Federal Ministry of Health (BMG Germany) under the BMG-WHO Collaboration Programme 2020-2023 (WHO specified award) [70672], Spanish Agency for International Cooperation (AECID) [71208], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université de Rennes (UR), Amsterdam UMC - Amsterdam University Medical Center, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), National Research Centre for the Working Environment (NRCWE), Chard-Hutchinson, Xavier, Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Public and occupational health, APH - Quality of Care, and APH - Societal Participation & Health
Subjects: Burden of disease, PROTOCOL, Occupational risk, [SDV]Life Sciences [q-bio], Environmental Sciences & Ecology, 010501 environmental sciences, Individual risk, World Health Organization, 01 natural sciences, Work related, Article, 03 medical and health sciences, 0302 clinical medicine, User experience design, Cost of Illness, Bias, Environmental health, Prevalence, Humans, QUALITY, GE1-350, 030212 general & internal medicine, Reliability (statistics), ComputingMethodologies_COMPUTERGRAPHICS, 0105 earth and related environmental sciences, General Environmental Science, Science & Technology, business.industry, Occupational epidemiology, Occupational exposure, Systematic review methods, Reproducibility of Results, SCIENCE, 3. Good health, Environmental sciences, Occupational Diseases, [SDV] Life Sciences [q-bio], SYSTEMATIC REVIEWS, Inter-rater reliability, Systematic review, ASSESSMENTS, RELIABILITY, Psychology, business, Life Sciences & Biomedicine, Environmental Sciences
Abstract: Graphical abstract, Highlights • Risk of bias (RoB) assessment is a critical step of a systematic review. • RoB-SPEO assesses RoB in prevalence studies of occupational risk factor exposure. • Inter-rater agreement for its domains ranged from proportions of 0.54–0.82. • Median time taken to complete one assessment using RoB-SPEO was 40 min. • User experience was positive but called for an online tool and further instructions., Background As part of the development of the World Health Organization (WHO)/International Labour Organization (ILO) Joint Estimates of the Work-related Burden of Disease and Injury, WHO and ILO carried out several systematic reviews to determine the prevalence of exposure to selected occupational risk factors. Risk of bias assessment for individual studies is a critical step of a systematic review. No tool existed for assessing the risk of bias in prevalence studies of exposure to occupational risk factors, so WHO and ILO developed and pilot tested the RoB-SPEO tool for this purpose. Here, we investigate the assessor burden, inter-rater agreement, and user experience of this new instrument, based on the abovementioned WHO/ILO systematic reviews. Methods Twenty-seven individual experts applied RoB-SPEO to assess risk of bias. Four systematic reviews provided a total of 283 individual assessments, carried out for 137 studies. For each study, two or more assessors independently assessed risk of bias across the eight RoB-SPEO domains selecting one of RoB-SPEO’s six ratings (i.e., “low”, “probably low”, “probably high”, “high”, “unclear” or “cannot be determined”). Assessors were asked to report time taken (i.e. indicator of assessor burden) to complete each assessment and describe their user experience. To gauge assessor burden, we calculated the median and inter-quartile range of times taken per individual risk of bias assessment. To assess inter-rater reliability, we calculated a raw measure of inter-rater agreement (Pi) for each RoB-SPEO domain, between Pi = 0.00, indicating no agreement and Pi = 1.00, indicating perfect agreement. As subgroup analyses, Pi was also disaggregated by systematic review, assessor experience with RoB-SPEO (≤10 assessments versus > 10 assessments), and assessment time (tertiles: ≤25 min versus 26–66 min versus ≥ 67 min). To describe user experience, we synthesised the assessors’ comments and recommendations. Results Assessors reported a median of 40 min to complete one assessment (interquartile range 21–120 min). For all domains, raw inter-rater agreement ranged from 0.54 to 0.82. Agreement varied by systematic review and assessor experience with RoB-SPEO between domains, and increased with increasing assessment time. A small number of users recommended further development of instructions for selected RoB-SPEO domains, especially bias in selection of participants into the study (domain 1) and bias due to differences in numerator and denominator (domain 7). Discussion Overall, our results indicated good agreement across the eight domains of the RoB-SPEO tool. The median assessment time was comparable to that of other risk of bias tools, indicating comparable assessor burden. However, there was considerable variation in time taken to complete assessments. Additional time spent on assessments may improve inter-rater agreement. Further development of the RoB-SPEO tool could focus on refining instructions for selected RoB-SPEO domains and additional testing to assess agreement for different topic areas and with a wider range of assessors from different research backgrounds.
Published: 2022

7. Boosting sunscreen stability: New hybrid materials from UV filters encapsulation

Author: Alfonso Zambon, Erika Ferrari, Francesco Di Renzo, Riccardo Fantini, Giovanna Vezzalini, Marco Fabbiani, Rossella Arletti, Department of Chemical and Geological Siences, University of Modena and Reggio-Emilia, The institute of cancer research [London], Université Paris-Saclay, CEA, CNRS, NIMBE, 91190 Gif-sur-Yvette, France, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), University of Torino, Department of Chemistry, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), and Università degli Studi di Modena e Reggio Emilia (UNIMORE)
Subjects: Encapsulated UV Filter, Materials science, Absorption, Eco-friendly sunscreen, Host-guest interaction, Hybrid material, Zeolite, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Human health, [CHIM]Chemical Sciences, General Materials Science, ComputingMilieux_MISCELLANEOUS, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, 3. Good health, chemistry, Mechanics of Materials, Avobenzone, 0210 nano-technology
Abstract: Unprotected exposure to solar UV is the main recognized cause of the spreading of skin cancer that has occurred in the last decades. Organic and inorganic UV filters are the main defense against UV exposure and have become ubiquitous in personal-care products, packaging, plastics, dyes, and many other sectors. UV filters still have some stability and efficacy issues making it important to find stable and broad-spectrum UV absorbers, safer for human health and the environment. In this work UV filters octinoxate and avobenzone were encapsulated into zeolites with different chemistry and topology leading to the production of hybrid zeolites/organic filter sunscreens. The obtained materials were deeply characterized and their filtering capacity evaluated. The encapsulation of UV filters in cationic zeolites resulted in an enhanced UV filtering capacity, whereas that in acid zeolites seem less effective in absorbing UV radiation, with emerging visible coloring. The enhancement of UV filtering power is of paramount importance for the future development and exploitation of ZEOfilters, possibly being the key to reduce the quantity of actives, stabilizers, and co-formulants employed, with benefits for humankind and the environment.
Published: 2021

8. Consensus statement on the role of health systems in advancing the long-term well-being of people living with HIV

Author: Graham S Cooke, Adeeba Kamarulzaman, Margaret Hellard, Jürgen K. Rockstroh, Kenneth H. Mayer, Georg M. N. Behrens, Denise Naniche, Nikos Dedes, Ricardo Baptista Leite, Jeffrey V. Lazarus, David Serwadda, Sanjay Bhagani, María José Fuster-Ruiz de Apodaca, Laura Waters, Shabbar Jaffar, Carlos F. Caceres, Diana Romero, Peter Reiss, Richard Elliott, Susan Buchbinder, Pedro Cahn, Richard Harding, Julia del Amo, Reena Rajasuriar, Teymur Noori, Kelly Safreed-Harmon, Antonella d'Arminio Monforte, Timothy B. Hallett, Jane Anderson, Wafaa El-Sadr, Darren L. Brown, Marina B. Klein, Doreen Moraa, Sharon R Lewin, Nesrine Rizk, Denis Nash, Giovanni Guaraldi, Graham Brown, Anton Pozniak, Georgina Caswell, Caroline A. Sabin, Linda-Gail Bekker, Patrizia Carrieri, Meaghan Kall, José Antonio Pérez-Molina, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), University of Malaya [Kuala Lumpur, Malaisie], Homerton University Hospital, Portuguese National Parliament [Lisbon, Portugal] (PNP), Medizinische Hochschule Hannover (MHH), The Desmond Tutu HIV Centre [Cape Town, South Africa], University College of London [London] (UCL), Chelsea and Westminster NHS Foundation Trust [London, UK], University of New South Wales [Sydney] (UNSW), San Francisco Department of Public Health [San Francisco, CA, USA] (SFDPH), Universidad Peruana Cayetano Heredia (UPCH), Fundación Huésped [Buenos Aires], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences de la santé publique [Marseille] (ISSPAM), Global Network of People Living with HIV (GNP+) [Cape Town, South Africa], Imperial College London, University of Milan, Positive Voice [Athens, Greece] (PV), Ministerio de Sanidad/Ministry of Health [Madrid, Spain], HIV Legal Network [Toronto, ON, Canada], Columbia University [New York], Universidad Nacional de Educación a Distancia (UNED), Università degli Studi di Modena e Reggio Emilia (UNIMORE), King‘s College London, Burnet Institute [Melbourne, Victoria], Liverpool School of Tropical Medicine (LSTM), Public Health England [London], McGill University Health Center [Montreal] (MUHC), The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, Monash University [Melbourne], Harvard Medical School [Boston] (HMS), Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), ESA YOUTH 2030 [Nairobi, Kenya], City University of New York [New York] (CUNY), European Centre for Disease Prevention and Control (ECDC), London School of Hygiene and Tropical Medicine (LSHTM), University of Amsterdam [Amsterdam] (UvA), American University of Beirut [Beyrouth] (AUB), University Hospital Bonn, Makerere University [Kampala, Ouganda] (MAK), Central and North West London NHS Foundation Trust [London, UK], University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Malbec, Odile, Ministerio de Sanidad / Ministry of Health [Madrid, Spain], European Centre for Disease Prevention and Control [Stockholm, Sweden] (ECDC), and Medical Research Council (MRC)
Subjects: Gerontology, SYMPTOMS, Social stigma, STIGMA REDUCTION, IMPACT, [SDV]Life Sciences [q-bio], Social Stigma, General Physics and Astronomy, wc_503, HIV Infections, Disease, Comorbidity, DISEASE, Comorbidities, socioeconomic conditions, 0302 clinical medicine, ANTIRETROVIRAL THERAPY, QUALITY-OF-LIFE, Surveys and Questionnaires, Health care, Medicine, 030212 general & internal medicine, RISK, Multidisciplinary, human immunodeficiency virus, 030503 health policy & services, Health services, 3. Good health, Multidisciplinary Sciences, [SDV] Life Sciences [q-bio], HUMAN-IMMUNODEFICIENCY-VIRUS, Perspective, Science & Technology - Other Topics, 0305 other medical science, Adult, Quality of life, wc_503_2, Consensus, Science, Stigma (botany), VALIDATION, General Biochemistry, Genetics and Molecular Biology, long-term change, 03 medical and health sciences, Quality of life (healthcare), Acquired immunodeficiency syndrome (AIDS), Humans, Science & Technology, business.industry, General Chemistry, CARE, medicine.disease, Mental health, quality of life, Well-being, Morbidity, business, Delivery of Health Care
Abstract: Health systems have improved their abilities to identify, diagnose, treat and, increasingly, achieve viral suppression among people living with HIV (PLHIV). Despite these advances, a higher burden of multimorbidity and poorer health-related quality of life are reported by many PLHIV in comparison to people without HIV. Stigma and discrimination further exacerbate these poor outcomes. A global multidisciplinary group of HIV experts developed a consensus statement identifying key issues that health systems must address in order to move beyond the HIV field’s longtime emphasis on viral suppression to instead deliver integrated, person-centered healthcare for PLHIV throughout their lives.
Published: 2021

9. Effect of strain on interactions of Σ 3{111} silicon grain boundary with oxygen impurities from first‐principles

Author: Rita Maji, Julia Contreras-García, Eleonora Luppi, Elena Degoli, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Laboratoire de chimie théorique (LCT), and Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010302 applied physics, [PHYS]Physics [physics], Condensed Matter - Materials Science, silicon grain boundaries, first principles, Silicon grain boundaries, first-principles, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Electronic, Optical and Magnetic Materials, oxygen impurities, Condensed Matter::Materials Science, strain, oxygen impurity, 0103 physical sciences, 0210 nano-technology
Abstract: The interaction of grain boundaries (GBs) with inherent defects and/or impurity elements in multi-crystalline silicon play a decisive role in their electrical behavior. Strain, depending on the types of GBs and defects, plays an important role in these systems. Herein, the correlation between the structural and electronic properties of {\Sigma} 3{111} Si-GB in the presence of interstitial oxygen impurities is studied from the first-principles framework, considering the global and local model of strain. It is observed that the distribution of strain along with the number of impurity atoms modifies the energetics of the material. However, the electronic properties of the considered Si-GBs are not particularly affected by the strain and by the oxygen impurities, unless a very high local distortion induces additional structural defects., Comment: EMRS-spring meeting 2021: Defect-induced effects in nanomaterials
Published: 2021

10. Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor

Author: De Pascali, Francesco, Ayoub, Mohammed, Benevelli, Riccardo, Sposini, Silvia, Lehoux, Jordan, Gallay, Nathalie, Raynaud, Pauline, Landomiel, Flavie, Jean-Alphonse, Frédéric, Gauthier, Christophe, Pellissier, Lucie P., Crepieux, Pascale, Poupon, Anne, Inoue, Asuka, Joubert, Nicolas, Viaud-Massuard, Marie-Claude, Casarini, Livio, Simoni, Manuela, Hanyaloglu, Aylin, Nataraja, Selva, Yu, Henry, Palmer, Stephen, Yvinec, Romain, Reiter, Eric, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), United Arab Emirates University (UAEU), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Imperial College London, Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours, Dynamiques de populations multi-échelles pour des systèmes physiologiques (MUSCA), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Tohoku University [Sendai], TocopheRx Inc, Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Université de Tours (UT), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE)
Subjects: QH301-705.5, Operational model, Allosteric ligands, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, allosteric ligands, beta-Arrestin 2, Article, GTP-Binding Protein alpha Subunits, Chemistry, Kinetics, Biased signaling, HEK293 Cells, FSHR, system bias, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Cyclic AMP, Humans, Receptors, FSH, Biology (General), Extracellular Signal-Regulated MAP Kinases, QD1-999, operational model, System bias, biased signaling
Abstract: International audience; Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the activation of multiple signaling pathways. Low molecular weight (LMW) ligands composed of biased agonist properties are highly valuable tools to decipher complex signaling mechanisms as they allow selective activation of discrete signaling cascades. However, available LMW FSHR ligands have not been fully characterized yet. In this context, we explored the pharmacological diversity of three benzamide and two thiazolidinone derivatives compared to FSH. Concentration/activity curves were generated for Gαs, Gαq, Gαi, β-arrestin 2 recruitment, and cAMP production, using BRET assays in living cells. ERK phosphorylation was analyzed by Western blotting, and CRE-dependent transcription was assessed using a luciferase reporter assay. All assays were done in either wild-type, Gαs or β-arrestin 1/2 CRISPR knockout HEK293 cells. Bias factors were calculated for each pair of read-outs by using the operational model. Our results show that each ligand presented a discrete pharmacological efficacy compared to FSH, ranging from super-agonist for β-arrestin 2 recruitment to pure Gαs bias. Interestingly, LMW ligands generated kinetic profiles distinct from FSH (i.e., faster, slower or transient, depending on the ligand) and correlated with CRE-dependent transcription. In addition, clear system biases were observed in cells depleted of either Gαs or β-arrestin genes. Such LMW properties are useful pharmacological tools to better dissect the multiple signaling pathways activated by FSHR and assess their relative contributions at the cellular and physio-pathological levels
Published: 2021

11. New Insights in the Production of Simulated Moon Agglutinates: the Use of Natural Zeolite-Bearing Rocks

Author: Serena Esposito, Paolo Maria Eugenio Icilio Allia, Michele Pansini, Rossella Arletti, Maela Manzoli, Barbara Bonelli, Aurélien Roggero, Gabriele Barrera, Paola Tiberto, Jean-Charles Matéo-Vélez, Olimpia Tammaro, Eric Dantras, Antonello Marocco, National Interuniversity Consortium of Materials Science and Technology (INSTM ), Department of Applied Science and Technology [Politecnico di Torino] (DISAT), Politecnico di Torino = Polytechnic of Turin (Polito), Università degli studi di Cassino e del Lazio Meridionale (UNICAS), Istituto Nazionale di Ricerca Metrologica (INRiM), ONERA / DPHY, Université de Toulouse [Toulouse], ONERA-PRES Université de Toulouse, Ingénierie des Matériaux Polymères (IMP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), and Università degli Studi di Modena e Reggio Emilia (UNIMORE)
Subjects: Atmospheric Science, Materials science, Electric properties, 02 engineering and technology, 010502 geochemistry & geophysics, 01 natural sciences, Natural (archaeology), law.invention, Nanocomposites, [SPI]Engineering Sciences [physics], Geochemistry and Petrology, law, Magnetic properties, Agglutinates, Zeolite, Lunar soil, 0105 earth and related environmental sciences, [PHYS]Physics [physics], Bearing (mechanical), Natural zeolites, 021001 nanoscience & nanotechnology, agglutinates, electric properties, lunar soil, magnetic properties, nanocomposites, nanophase iron, natural zeolites, Nanophase iron, Chemical engineering, Space and Planetary Science, 0210 nano-technology
Abstract: International audience; Two natural zeolite-bearing rocks (one containing clinoptilolite and the other chabazite, phillipsite, and analcime) were Fe-exchanged and thermally treated in a reducing atmosphere at 750 °C for 2 h. Two nanocomposites, formed by the dispersion of Fe nanoparticles in a ceramic matrix, were obtained. The prepared lunar dust simulants also contain Na+, K+, Ca2+, and Mg2+ and other mineral phases originally present in the starting materials. The samples were fully characterized by different techniques such as atomic absorption spectrometry, X-ray powder diffraction, followed by Rietveld analysis, transmission electron microscopy, N2 adsorption/desorption analysis at 77 K, measurements of grain size distribution, magnetic property measurements, broad-band dielectric spectroscopy, and DC conductivity measurements. The results of this characterization showed that the obtained metal–ceramic nanocomposites exhibit a chemical and mineralogical composition and electrical and magnetic properties similar to real moon dust and, thus, appear valid moon dust simulants.
Published: 2021

12. High-Pressure Synthesis and Gas-Sensing Tests of 1-D Polymer/Aluminophosphate Nanocomposites

Author: Marco Fabbiani, Frederico G. Alabarse, Michelangelo Polisi, Giulia Zambotti, Francesco Di Renzo, Boby Joseph, Andrea Ponzoni, Vittorio Ferrari, S. Quartieri, Julien Haines, Rossella Arletti, Marco Baù, Marco Ferrari, Francesco Capitani, Mario Santoro, Leszek Konczewicz, Sylvie Contreras, Jérôme Rouquette, Bruno Alonso, Elettra Sincrotrone Trieste, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Università degli studi di Torino (UNITO), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Dipartimento di Scienze della Terra [Torino], Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Ottica (INO), Consiglio Nazionale delle Ricerche (CNR), Università degli Studi di Brescia [Brescia], European Laboratory for Non-Linear Spectroscopy (LENS), and Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)
Subjects: gas sensing, Nanostructure, Materials science, aluminophosphate, polymer, Composite number, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Diamond anvil cell, Crystal, chemistry.chemical_compound, nanocomposites, General Materials Science, chemistry.chemical_classification, Nanocomposite, high-pressure synthesis, Polymer, 021001 nanoscience & nanotechnology, 0104 chemical sciences, [CHIM.POLY]Chemical Sciences/Polymers, Phenylacetylene, chemistry, Chemical engineering, Polymerization, 0210 nano-technology
Abstract: International audience; Recently, filling zeolites with gaseous hydrocarbons at high pressures in diamond anvil cells has been carried out to synthesize novel polymer-guest/zeolite-host nanocomposites with potential, intriguing applications, although the small amount of materials, 10–7 cm3, severely limited true technological exploitation. Here, liquid phenylacetylene, a much more practical reactant, was polymerized in the 12 Å channels of the aluminophosphate Virginia Polytechnic Institute—Five (VFI) at about 0.8 GPa and 140 °C, with large volumes in the order of 0.6 cm3. The resulting polymer/VFI composite was investigated by synchrotron X-ray diffraction and optical and 1H, 13C, and 27Al nuclear magnetic resonance spectroscopy. The materials, consisting of disordered π-conjugated polyphenylacetylene chains in the pores of VFI, were deposited on quartz crystal microbalances and tested as gas sensors. We obtained promising sensing performances to water and butanol vapors, attributed to the finely tuned nanostructure of the composites. High-pressure synthesis is used here to obtain an otherwise unattainable true technological material.
Published: 2021

13. Mental health of refugees and migrants during the covid-19 pandemic: the role of experienced discrimination and daily stressors

Author: An Verelst, Eva Spiritus-Beerden, Beatriz Padilla, Gesine Sturm, Amer Shehadeh, Katerina Vasilikou, Sara Willems, Maria van den Muijsenbergh, Fábio Botelho Guedes, Nina Langer Primdahl, Stéphanie De Maesschalck, Elisabeth Ioannidi, Ilse Derluyn, Margarida Gaspar de Matos, Virginia Paloma, Antonio Chiarenza, Ines Devlieger, Rachid Oulahal, Charles Watters, Morten Skovdal, Rebecca Murphy, Rocío Garrido, Natalie Durbeej, Fatumo Osman, Universiteit Gent = Ghent University [Belgium] (UGENT), IT University of Copenhagen, Universidade de Lisboa (ULISBOA), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Uppsala University, University of Sevilla, National and Kapodistrian University of Athens (NKUA), National University of Ireland Maynooth (Maynooth University), Déplacements, Identités, Regards, Écritures (DIRE), Université de La Réunion (UR), Dalarna University, University of South Florida [Tampa] (USF), Instituto Universitário de Lisboa (ISCTE-IUL), Al Istiqlal University, Laboratoire Cliniques Pathologique et Interculturelle (LCPI), Université Toulouse - Jean Jaurès (UT2J), Radboud university [Nijmegen], Academy of Athens, University of Sussex, and Universidad de Sevilla. Departamento de Psicología Social
Subjects: IMPACT, Health, Toxicology and Mutagenesis, Psychological intervention, Social Sciences, [SHS.PSY]Humanities and Social Sciences/Psychology, migrants, 0302 clinical medicine, Pandemic, Medicine and Health Sciences, Global health, 030212 general & internal medicine, 10. No inequality, TRAUMA, Transients and Migrants, education.field_of_study, 1. No poverty, WOMEN, Public Health, Global Health, Social Medicine and Epidemiology, refugees, 3. Good health, Health, Medicine, Female, Public Health, Psychology, mental health, medicine.medical_specialty, Refugee, Population, EBOLA, Article, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, Social support, All institutes and research themes of the Radboud University Medical Center, Environmental health, medicine, Humans, Toxicology and Mutagenesis, education, Pandemics, SARS-CoV-2, Public health, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, COVID-19, Mental health, PERCEIVED DISCRIMINATION, 030227 psychiatry, MODEL, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, SOCIAL SUPPORT, discrimination
Abstract: International audience; The COVID-19 pandemic is a defining global health crisis of our time. While the impact of COVID-19, including its mental health impact, is increasingly being documented, there remain important gaps regarding the specific consequences of the pandemic on particular population groups, including refugees and migrants. This study aims to uncover the impact of the COVID-19 pandemic on the mental health of refugees and migrants worldwide, disentangling the possible role of social and daily stressors, i.e., experiences of discrimination and daily living conditions. Descriptive analysis and structural equation modeling were used to analyze the responses of N = 20,742 refugees and migrants on the self-reporting global ApartTogether survey. Survey findings indicated that the mental health of refugees and migrants during the COVID-19 pandemic was significantly impacted, particularly for certain subgroups, (i.e., insecure housing situation and residence status, older respondents, and females) who reported experiencing higher levels of increased discrimination and increases in daily life stressors. There is a need to recognize the detrimental mental health impact of the COVID-19 pandemic on particular refugee and migrant groups and to develop interventions that target their unique needs.
Published: 2021

14. Reduced FSH and LH action:implications for medically assisted reproduction

Author: Pascale Crépieux, Aylin C. Hanyaloglu, Nick Raine-Fenning, Monica Lispi, Alessandro Conforti, S Kol, D Chuderland, V Rochira, C. Alviggi, Ernesto Bosch, Peter Humaidan, Manuela Simoni, Thomas D'Hooghe, Instituo Valenciano de Infertilitad (IVI), University of Naples Federico II = Università degli studi di Napoli Federico II, Merck KGaA [Darmstadt, Germany], Merck & Co. Inc, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Imperial College London, University of Nottingham, UK (UON), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Dynamiques de populations multi-échelles pour des systèmes physiologiques (MUSCA), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Elisha Hospital, Azienda Ospedaleria Universitaria di Modena, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Yale University [New Haven], Aarhus University [Aarhus], Bosch, E, Alviggi, C, Lispi, M, Conforti, A, Hanyaloglu, A C, Chuderland, D, Simoni, M, Raine-Fenning, N, Crépieux, P, Kol, S, Rochira, V, D'Hooghe, T, Humaidan, P, University of Naples Federico II, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE)
Subjects: LH, LH / FSH / gonadotropins / LH and FSH deficiency / polymorphisms / recombinant LH / recombinant FSH / hypo-response / ovarian stimulation, Estradiol, Female, Gonadotropins, Humans, Luteinizing Hormone, Reproduction, Follicle Stimulating Hormone, Gonadotropin-Releasing Hormone, Gonadotropin-releasing hormone, recombinant FSH, Follicle-stimulating hormone, 0302 clinical medicine, FSH, media_common, 0303 health sciences, 030219 obstetrics & reproductive medicine, Recombinant LH, Rehabilitation, Obstetrics and Gynecology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, ovarian stimulation, medicine.anatomical_structure, Ovarian stimulation, Gonadotropin, Luteinizing hormone, hormones, hormone substitutes, and hormone antagonists, Recombinant FSH, medicine.medical_specialty, endocrine system, medicine.drug_class, media_common.quotation_subject, Mini Review, Biology, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction, 03 medical and health sciences, Anterior pituitary, Hypogonadotropic hypogonadism, Internal medicine, medicine, recombinant LH, Ovarian follicle, Ovulation, 030304 developmental biology, hypo-response, Hypo-response, LH and FSH deficiency, medicine.disease, AcademicSubjects/MED00905, Endocrinology, Reproductive Medicine, polymorphisms, Polymorphisms
Abstract: Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles in follicle development and ovulation via a complex interaction in the hypothalamus, anterior pituitary gland, reproductive organs, and oocytes. Impairment of the production or action of gonadotropins causes relative or absolute LH and FSH deficiency that compromises gametogenesis and gonadal steroid production, thereby reducing fertility. In women, LH and FSH deficiency is a spectrum of conditions with different functional or organic causes that are characterized by low or normal gonadotropin levels and low oestradiol levels. While the causes and effects of reduced LH and FSH production are very well known, the notion of reduced action has received less attention by researchers. Recent evidence shows that molecular characteristics, signalling as well as ageing, and some polymorphisms negatively affect gonadotropin action. These findings have important clinical implications, in particular for medically assisted reproduction in which diminished action determined by the afore-mentioned factors, combined with reduced endogenous gonadotropin production caused by GnRH analogue protocols, may lead to resistance to gonadotropins and, thus, to an unexpected hypo-response to ovarian stimulation. Indeed, the importance of LH and FSH action has been highlighted by the International Committee for Monitoring Assisted Reproduction Technologies (ICMART) in their definition of hypogonadotropic hypogonadism as gonadal failure associated with reduced gametogenesis and gonadal steroid production due to reduced gonadotropin production or action. The aim of this review is to provide an overview of determinants of reduced FSH and LH action that are associated with a reduced response to ovarian stimulation. ispartof: HUMAN REPRODUCTION vol:36 issue:6 pages:1469-1480 ispartof: location:England status: published
Published: 2021

15. The Parallel Multi-Mode Digraph Task Model for Energy-Aware Real-Time Heterogeneous Multi-Core Systems

Author: Houssam-Eddine Zahaf, Pierre Boulet, Marko Bertogna, Giuseppe Lipari, Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia (UNIMORE), and Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE)
Subjects: Multi-core processor, Computational complexity theory, Computer science, Digraph, Energy aware, Parallel programming, Real-time systems, 02 engineering and technology, Parallel computing, Directed graph, 020202 computer hardware & architecture, Theoretical Computer Science, Task (project management), Set (abstract data type), Computational Theory and Mathematics, Hardware and Architecture, [INFO.INFO-SY]Computer Science [cs]/Systems and Control [cs.SY], 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], [INFO.INFO-OS]Computer Science [cs]/Operating Systems [cs.OS], Dichotomic search, Heuristics, ComputingMilieux_MISCELLANEOUS, Software
Abstract: Many task models have been proposed to express and analyze the behavior of real-time applications at different levels of precision. Most of them target sequential applications with no support for parallelism. The digraph task model is one of the most general ones, as it allows modeling arbitrary directed graphs (digraphs) for sequential job releases. In this paper, we extend the digraph task model to support intra-task parallelism. For the proposed parallel multi-mode digraph model, we derive sufficient schedulability tests and a dichotomic search to improve the test pessimism for a set of $n$n tasks onto a heterogeneous single-ISA multi-core platform. To reduce the computational complexity of the schedulability test, we also propose heuristics for (i) partitioning parallel digraph tasks onto the heterogeneous cores, and (ii) assigning core operating frequencies to reduce the overall energy consumption, while meeting real-time constraints. The effectiveness of the proposed approach is validated with an exhaustive set of simulations.
Published: 2019

16. Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

Author: Jean-Baptiste Manneville, Irene Brian, Silvia Pedretti, Patrizia Romani, Arianna Pocaterra, Mattia Forcato, Silvio Bicciato, Samuel Mathieu, Nico Mitro, Sirio Dupont, Matteo Audano, Giulia Santinon, Universita degli Studi di Padova, University of Milan, Compartimentation et dynamique cellulaires (CDC), Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Curie [Paris], Université Paris sciences et lettres (PSL), Sorbonne Université (SU), Università degli Studi di Modena e Reggio Emilia (UNIMORE), and Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: Cell Biology, Mechanobiology, Metabolism, Metabolomics, Lipids, Lipin-1, phosphatidate phosphatase, SREBP, Golgi apparatus, Cellular differentiation, Phosphatidate Phosphatase, Golgi Apparatus, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, SREBP, Cell Line, Cell-Matrix Junctions, Mechanobiology, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Cell Line, Tumor, Extracellular, Humans, Metabolomics, PI3K/AKT/mTOR pathway, Cell Proliferation, 030304 developmental biology, Sterol Regulatory Element Binding Proteins, 0303 health sciences, Chemistry, Lipin-1, Cell Differentiation, Lipid metabolism, Cell Biology, Golgi apparatus, Phosphatidate phosphatase, Lipid Metabolism, Lipids, Extracellular Matrix, Sterol regulatory element-binding protein, Cell biology, Metabolism, Cellular Microenvironment, 030220 oncology & carcinogenesis, symbols, lipids (amino acids, peptides, and proteins), Cues, Signal transduction, Signal Transduction
Abstract: International audience; Extracellular matrix (ECM) mechanical cues have powerful effects on cell proliferation, differentiation and death. Here, starting from an unbiased metabolomics approach, we identify synthesis of neutral lipids as a general response to mechanical signals delivered by cell–matrix adhesions. Extracellular physical cues reverberate on the mechanical properties of the Golgi apparatus and regulate the Lipin-1 phosphatidate phosphatase. Conditions of reduced actomyosin contractility lead to inhibition of Lipin-1, accumulation of SCAP/SREBP to the Golgi apparatus and activation of SREBP transcription factors, in turn driving lipid synthesis and accumulation. This occurs independently of YAP/TAZ, mTOR and AMPK, and in parallel to feedback control by sterols. Regulation of SREBP can be observed in a stiffened diseased tissue, and contributes to the pro-survival activity of ROCK inhibitors in pluripotent stem cells. We thus identify a general mechanism centered on Lipin-1 and SREBP that links the physical cell microenvironment to a key metabolic pathway.
Published: 2019

17. Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenitor Cells for Therapeutic Genomic Rearrangements

Author: Cécile Masson, Mario Amendola, Annarita Miccio, Annalisa Lattanzi, Ciaran M. Lee, Chiara Antoniani, Sophie Ramadier, Gang Bao, Olivier Alibeu, Vasco Meneghini, Tristan Felix, Matthew H. Porteus, Giulia Pavani, Fulvio Mavilio, Fatima Amor, Approches génétiques intégrées et nouvelles thérapies pour les maladies rares (INTEGRARE), Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Généthon-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Généthon, Chromatin and gene regulation during development (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Plateforme Bioinformatique [SFR Necker] (BIP-D), Structure Fédérative de Recherche Necker (SFR Necker - UMS 3633 / US24), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Rice University [Houston], Stanford University, Università degli Studi di Modena e Reggio Emilia (UNIMORE), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Généthon, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), CCSD, Accord Elsevier, École Pratique des Hautes Études (EPHE), Chromatin and gene regulation during development, and ANR-16-CE18-0004,GETH,L'Édition Génomique comme outil Thérapeutique contre les ß-Hémoglobinopathies(2016)
Subjects: [SDV]Life Sciences [q-bio], Genetic enhancement, Anemia, Sickle Cell, Biology, Heterogeneous-Nuclear Ribonucleoproteins, Viral vector, 03 medical and health sciences, 0302 clinical medicine, Genome editing, CRISPR-Associated Protein 9, hemic and lymphatic diseases, Drug Discovery, Genetics, Humans, CRISPR, Progenitor cell, Molecular Biology, 030304 developmental biology, Gene Editing, Pharmacology, 0303 health sciences, Cas9, beta-Thalassemia, Genetic Therapy, Hematopoietic Stem Cells, 3. Good health, Cell biology, Hemoglobinopathies, [SDV] Life Sciences [q-bio], Haematopoiesis, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, CRISPR-Cas Systems, Stem cell, Plasmids, RNA, Guide, Kinetoplastida, CRISPR/Cas9 delivery, genome editing, β-hemoglobinopathies, Drug Discovery3003 Pharmaceutical Science
Abstract: International audience; Editing the beta-globin locus in hematopoietic stem cells is an alternative therapeutic approach for gene therapy of beta-thalassemia and sickle cell disease. Using the CRISPR/Cas9 system, we genetically modified human hematopoietic stem and progenitor cells (HSPCs) to mimic the large rearrangements in the beta-globin locus associated with hereditary persistence of fetal hemoglobin (HPFH), a condition that mitigates the clinical phenotype of patients with beta-hemoglobinopathies. We optimized and compared the efficiency of plasmid-, lentiviral vector (LV)-, RNA-, and ribonucleoprotein complex (RNP)-based methods to deliver the CRISPR/Cas9 system into HSPCs. Plasmid delivery of Cas9 and gRNA pairs targeting two HPFH-like regions led to high frequency of genomic rearrangements and HbF reactivation in erythroblasts derived from sorted, Cas9(+) HSPCs but was associated with significant cell toxicity. RNA-mediated delivery of CRISPR/Cas9 was similarly toxic but much less efficient in editing the beta-globin locus. Transduction of HSPCs by LVs expressing Cas9 and gRNA pairs was robust and minimally toxic but resulted in poor genome-editing efficiency. Ribonucleoprotein (RNP)-based delivery of CRISPR/Cas9 exhibited a good balance between cytotoxicity and efficiency of genomic rearrangements as compared to the other delivery systems and resulted in HbF upregulation in erythroblasts derived from unselected edited HSPCs.
Published: 2019

18. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Author: Lara Gibellini, Sussan Nourshargh, Susanna Cardell, Wlodzimierz Maslinski, Mar Felipo-Benavent, Florian Mair, Hans-Martin Jäck, Lilly Lopez, Klaus Warnatz, John Trowsdale, Diana Ordonez, Marcus Eich, William Hwang, Anne Cooke, Dirk Mielenz, Alberto Orfao, Winfried F. Pickl, Vladimir Benes, Alice Yue, T. Vincent Shankey, Maria Tsoumakidou, Virginia Litwin, Gelo Victoriano Dela Cruz, Andrea Cavani, Sara De Biasi, Larissa Nogueira Almeida, Jonathan J M Landry, Claudia Haftmann, Charlotte Esser, Ana Cumano, Anneke Wilharm, Francesco Dieli, Rudi Beyaert, Alessio Mazzoni, Burkhard Ludewig, Carlo Pucillo, Dirk H. Busch, Joe Trotter, Stipan Jonjić, Marc Veldhoen, Josef Spidlen, Aja M. Rieger, Dieter Adam, Srijit Khan, Todd A. Fehniger, Giuseppe Matarese, Maximilien Evrard, Christian Maueröder, Steffen Schmitt, Kristin A. Hogquist, Barry Moran, Raghavendra Palankar, Markus Feuerer, S Schmid, Susann Rahmig, Amy E. Lovett-Racke, James V. Watson, Megan K. Levings, Susanne Melzer, Dinko Pavlinic, Christopher M. Harpur, Christina Stehle, A. Graham Pockley, Toshinori Nakayama, Attila Tárnok, Juhao Yang, Michael Lohoff, Paulo Vieira, Francisco Sala-de-Oyanguren, Christian Kurts, Anastasia Gangaev, Alfonso Blanco, Hans Scherer, Regine J. Dress, Bruno Silva-Santos, Kiyoshi Takeda, Bimba F. Hoyer, Ilenia Cammarata, Daryl Grummitt, Isabel Panse, Günnur Deniz, Bianka Baying, Friederike Ebner, Esther Schimisky, Leo Hansmann, Thomas Kamradt, Edwin van der Pol, Daniel Scott-Algara, Anna Iannone, Giorgia Alvisi, Sebastian R. Schulz, Francesco Liotta, Irmgard Förster, Beatriz Jávega, Hans-Peter Rahn, Caetano Reis e Sousa, Livius Penter, Xuetao Cao, David P. Sester, Keisuke Goda, Peter Wurst, Iain B. McInnes, Ricardo T. Gazzinelli, Federica Piancone, Gerald Willimsky, Yotam Raz, Pärt Peterson, Wolfgang Fritzsche, Yvonne Samstag, Martin Büscher, Thomas Schüler, Susanne Hartmann, Robert J. Wilkinson, Anna E. S. Brooks, Steven L. C. Ketelaars, Catherine Sautès-Fridman, Anna Rubartelli, Petra Bacher, Katja Kobow, Marco A. Cassatella, Andrea Hauser, Henrik E. Mei, Kilian Schober, Silvia Della Bella, Graham Anderson, Michael D. Ward, Garth Cameron, Sebastian Lunemann, Katharina Kriegsmann, Katarzyna M. Sitnik, Brice Gaudilliere, Chantip Dang-Heine, Marcello Pinti, Paul Klenerman, Frank A. Schildberg, Joana Barros-Martins, Laura G. Rico, Hanlin Zhang, Christian Münz, Thomas Dörner, Jakob Zimmermann, Andrea M. Cooper, Jonni S. Moore, Andreas Diefenbach, Yanling Liu, Wolfgang Bauer, Tobit Steinmetz, Katharina Pracht, Leonard Tan, Peter K. Jani, Alan M. Stall, Petra Hoffmann, Christine S. Falk, Jasmin Knopf, Simon Fillatreau, Hans-Dieter Volk, Luis E. Muñoz, David L. Haviland, William W. Agace, Jonathan Rebhahn, Ljiljana Cvetkovic, Mohamed Trebak, Jordi Petriz, Mario Clerici, Diether J. Recktenwald, Anders Ståhlberg, Tristan Holland, Helen M. McGuire, Sa A. Wang, Christian Kukat, Thomas Kroneis, Laura Cook, Wan Ting Kong, Xin M. Wang, Britta Engelhardt, Pierre Coulie, Genny Del Zotto, Sally A. Quataert, Kata Filkor, Gabriele Multhoff, Bartek Rajwa, Federica Calzetti, Hans Minderman, Cosima T. Baldari, Jens Geginat, Hervé Luche, Gert Van Isterdael, Linda Schadt, Sophia Urbanczyk, Giovanna Borsellino, Liping Yu, Dale I. Godfrey, Achille Anselmo, Rachael C. Walker, Andreas Grützkau, David W. Hedley, Birgit Sawitzki, Silvia Piconese, Maria Yazdanbakhsh, Burkhard Becher, Ramon Bellmas Sanz, Michael Delacher, Hyun-Dong Chang, Immanuel Andrä, Hans-Gustaf Ljunggren, José-Enrique O'Connor, Ahad Khalilnezhad, Sharon Sanderson, Federico Colombo, Götz R. A. Ehrhardt, Inga Sandrock, Enrico Lugli, Christian Bogdan, James B. Wing, Susann Müller, Tomohiro Kurosaki, Derek Davies, Ester B. M. Remmerswaal, Kylie M. Quinn, Christopher A. Hunter, Andreas Radbruch, Timothy P. Bushnell, Anna Erdei, Sabine Adam-Klages, Pascale Eede, Van Duc Dang, Rieke Winkelmann, Thomas Korn, Gemma A. Foulds, Dirk Baumjohann, Matthias Schiemann, Manfred Kopf, Jan Kisielow, Lisa Richter, Jochen Huehn, Gloria Martrus, Alexander Scheffold, Jessica G. Borger, Sidonia B G Eckle, John Bellamy Foster, Anna Katharina Simon, Alicia Wong, Mübeccel Akdis, Gisa Tiegs, Toralf Kaiser, James McCluskey, Anna Vittoria Mattioli, Aaron J. Marshall, Hui-Fern Koay, Eva Orlowski-Oliver, Anja E. Hauser, J. Paul Robinson, Jay K. Kolls, Luca Battistini, Mairi McGrath, Jane L. Grogan, Natalio Garbi, Timothy Tree, Kingston H. G. Mills, Stefan H. E. Kaufmann, Wolfgang Schuh, Ryan R. Brinkman, Tim R. Mosmann, Vincenzo Barnaba, Andreas Dolf, Lorenzo Cosmi, Bo Huang, Andreia C. Lino, Baerbel Keller, René A. W. van Lier, Alexandra J. Corbett, Paul S. Frenette, Pleun Hombrink, Helena Radbruch, Sofie Van Gassen, Olivier Lantz, Lorenzo Moretta, Désirée Kunkel, Kirsten A. Ward-Hartstonge, Armin Saalmüller, Leslie Y. T. Leung, Salvador Vento-Asturias, Paola Lanuti, Alicia Martínez-Romero, Sarah Warth, Zhiyong Poon, Diana Dudziak, Andrea Cossarizza, Kovit Pattanapanyasat, Konrad von Volkmann, Jessica P. Houston, Agnès Lehuen, Andrew Filby, Pratip K. Chattopadhyay, Stefano Casola, Annika Wiedemann, Hannes Stockinger, Jürgen Ruland, Arturo Zychlinsky, Claudia Waskow, Katrin Neumann, Ari Waisman, Lucienne Chatenoud, Sudipto Bari, Kamran Ghoreschi, David W. Galbraith, Yvan Saeys, Hamida Hammad, Andrea Gori, Miguel López-Botet, Gabriel Núñez, Sabine Ivison, Michael Hundemer, Dorothea Reimer, Mark C. Dessing, Günter J. Hämmerling, Rudolf A. Manz, Tomas Kalina, Jonas Hahn, Holden T. Maecker, Hendy Kristyanto, Martin S. Davey, Henning Ulrich, Michael L. Dustin, Takashi Saito, Yousuke Takahama, Milena Nasi, Johanna Huber, Jürgen Wienands, Paolo Dellabona, Andreas Schlitzer, Michael D. Leipold, Kerstin H. Mair, Christian Peth, Immo Prinz, Chiara Romagnani, José M. González-Navajas, Josephine Schlosser, Marina Saresella, Matthias Edinger, Dirk Brenner, Nicole Baumgarth, Rikard Holmdahl, Fang-Ping Huang, Guadalupe Herrera, Malte Paulsen, Gergely Toldi, Luka Cicin-Sain, Reiner Schulte, Christina E. Zielinski, Thomas Winkler, Christoph Goettlinger, Philip E. Boulais, Jennie H M Yang, Antonio Celada, Heike Kunze-Schumacher, Julia Tornack, Florian Ingelfinger, Jenny Mjösberg, Andy Riddell, Leonie Wegener, Thomas Höfer, Christoph Hess, James P. Di Santo, Anna E. Oja, J. Kühne, Willem van de Veen, Mary Bebawy, Alberto Mantovani, Bart Everts, Giovanna Lombardi, Laura Maggi, Anouk von Borstel, Pia Kvistborg, Elisabetta Traggiai, A Ochel, Nima Aghaeepour, Charles-Antoine Dutertre, Matthieu Allez, Thomas Höllt, Wenjun Ouyang, Regina Stark, Maries van den Broek, Shimon Sakaguchi, Paul K. Wallace, Silvano Sozzani, Francesca LaRosa, Annette Oxenius, Malgorzata J. Podolska, Ivana Marventano, Wilhelm Gerner, Oliver F. Wirz, Britta Frehse, Gevitha Ravichandran, Martin Herrmann, Carl S. Goodyear, Gary Warnes, Helen Ferry, Stefan Frischbutter, Tim R. Radstake, Salomé LeibundGut-Landmann, Yi Zhao, Axel Schulz, Angela Santoni, Pablo Engel, Daniela C. Hernández, Andreas Acs, Cristiano Scottà, Francesco Annunziato, Thomas Weisenburger, Wolfgang Beisker, Sue Chow, Fritz Melchers, Daniel E. Speiser, Immanuel Kwok, Florent Ginhoux, Dominic A. Boardman, Natalie Stanley, Carsten Watzl, Marie Follo, Erik Lubberts, Andreas Krueger, Susanne Ziegler, Göran K. Hansson, David Voehringer, Antonia Niedobitek, Eleni Christakou, Lai Guan Ng, Sabine Baumgart, Nicholas A Gherardin, Antonio Cosma, Orla Maguire, Jolene Bradford, Daniel Schraivogel, Linda Quatrini, Stephen D. Miller, Rheumatology, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Deutsches Rheuma-ForschungsZentrum (DRFZ), Deutsches Rheuma-ForschungsZentrum, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université de Paris (UP), Ecotaxie, microenvironnement et développement lymphocytaire (EMily (UMR_S_1160 / U1160)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Department of Internal Medicine, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)-DENOTHE Center, Institute of Clinical Molecular Biology, Kiel University, Department of Life Sciences [Siena, Italy], Università degli Studi di Siena = University of Siena (UNISI), Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP), Dulbecco Telethon Institute/Department of Biology, Caprotec Bioanalytics GmbH, International Occultation Timing Association European Section (IOTA ES), International Occultation Timing Association European Section, European Molecular Biology Laboratory [Heidelberg] (EMBL), VIB-UGent Center for Inflammation Research [Gand, Belgique] (IRC), VIB [Belgium], Fondazione Santa Lucia (IRCCS), Department of Immunology, Chinese Academy of Medical Sciences, FIRC Institute of Molecular Oncology Foundation, IFOM, Istituto FIRC di Oncologia Molecolare (IFOM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Physiopatology and Transplantation, University of Milan (DEPT), University of Milan, Monash University [Clayton], Institut des Maladies Emergentes et des Thérapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institute of Cellular Pathology, Université Catholique de Louvain = Catholic University of Louvain (UCL), Lymphopoïèse (Lymphopoïèse (UMR_1223 / U1223 / U-Pasteur_4)), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Experimental Immunology Unit, Dept. of Oncology, DIBIT San Raffaele Scientific Institute, Immunité Innée - Innate Immunity, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Biopharmacy [Bruxelles, Belgium] (Institute for Medical Immunology IMI), Université libre de Bruxelles (ULB), Charité Hospital, Humboldt-Universität zu Berlin, Agency for science, technology and research [Singapore] (A*STAR), Laboratory of Molecular Immunology and the Howard Hughes Institute, Rockefeller University [New York], Kennedy Institute of Rheumatology [Oxford, UK], Imperial College London, Theodor Kocher Institute, University of Bern, Leibniz Research Institute for Environmental Medicine [Düsseldorf, Germany] ( IUF), Université Lumière - Lyon 2 (UL2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), University of Edinburgh, Integrative Biology Program [Milano], Istituto Nazionale Genetica Molecolare [Milano] (INGM), Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Universitat de Barcelona (UB), Rheumatologie, Cell Biology, Department of medicine [Stockholm], Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm], Department for Internal Medicine 3, Institute for Clinical Immunology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Delft University of Technology (TU Delft), Medical Inflammation Research, Karolinska Institutet [Stockholm], Department of Photonics Engineering [Lyngby], Technical University of Denmark [Lyngby] (DTU), Dpt of Experimental Immunology [Braunschweig], Helmholtz Centre for Infection Research (HZI), Department of Internal Medicine V, Universität Heidelberg [Heidelberg], Department of Histology and Embryology, University of Rijeka, Freiburg University Medical Center, Nuffield Dept of Clinical Medicine, University of Oxford [Oxford]-NIHR Biomedical Research Centre, Institute of Integrative Biology, Molecular Biomedicine, Berlin Institute of Health (BIH), Laboratory for Lymphocyte Differentiation, RIKEN Research Center, Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, Immunité et cancer (U932), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Department of Surgery [Vancouver, BC, Canada] (Child and Family Research Institute), University of British Columbia (UBC)-Child and Family Research Institute [Vancouver, BC, Canada], College of Food Science and Technology [Shangai], Shanghai Ocean University, Institute for Medical Microbiology and Hygiene, University of Marburg, King‘s College London, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Centre d'Immunophénomique (CIPHE), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Brustzentrum Kantonsspital St. Gallen, Immunotechnology Section, Vaccine Research Center, National Institutes of Health [Bethesda] (NIH)-National Institute of Allergy and Infectious Diseases, Heinrich Pette Institute [Hamburg], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Department of Immunology and Cell Biology, Mario Negri Institute, Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi ONLUS Foundation, Institute of Translational Medicine, Klinik für Dermatologie, Venerologie und Allergologie, School of Biochemistry and Immunology, Department of Medicine Huddinge, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Lipid Laboratory, Università di Genova, Dipartimento di Medicina Sperimentale, Department of Environmental Microbiology, Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Department of Radiation Oncology [Munich], Ludwig-Maximilians-Universität München (LMU), Centre de Recherche Publique- Santé, Université du Luxembourg (Uni.lu), William Harvey Research Institute, Barts and the London Medical School, University of Michigan [Ann Arbor], University of Michigan System, Centro de Investigacion del Cancer (CSIC), Universitario de Salamanca, Molecular Pathology [Tartu, Estonia], University of Tartu, Hannover Medical School [Hannover] (MHH), Centre d'Immunologie de Marseille - Luminy (CIML), Monash Biomedicine Discovery Institute, Cytometry Laboratories and School of Veterinary Medicine, Purdue University [West Lafayette], Data Mining and Modelling for Biomedicine [Ghent, Belgium], VIB Center for Inflammation Research [Ghent, Belgium], Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, RIKEN Research Center for Allergy and Immunology, Osaka University [Osaka], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Institute of Medical Immunology [Berlin, Germany], FACS and Array Core Facility, Johannes Gutenberg - Universität Mainz (JGU), Otto-von-Guericke University [Magdeburg] (OVGU), SUPA School of Physics and Astronomy [University of St Andrews], University of St Andrews [Scotland]-Scottish Universities Physics Alliance (SUPA), Biologie Cellulaire des Lymphocytes - Lymphocyte Cell Biology, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), General Pathology and Immunology (GPI), University of Brescia, Université de Lausanne (UNIL), Terry Fox Laboratory, BC Cancer Agency (BCCRC)-British Columbia Cancer Agency Research Centre, Department of Molecular Immunology, Medizinische Universität Wien = Medical University of Vienna, Dept. Pediatric Cardiology, Universität Leipzig [Leipzig], Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Center for Cardiovascular Sciences, Albany Medical College, Dept Pathol, Div Immunol, University of Cambridge [UK] (CAM), Department of Information Technology [Gent], Universiteit Gent, Department of Plant Systems Biology, Department of Plant Biotechnology and Genetics, Universiteit Gent = Ghent University [Belgium] (UGENT), Division of Molecular Immunology, Institute for Immunology, Department of Geological Sciences, University of Oregon [Eugene], Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, University of Colorado [Colorado Springs] (UCCS), FACS laboratory, Cancer Research, London, Cancer Research UK, Regeneration in Hematopoiesis and Animal Models of Hematopoiesis, Faculty of Medicine, Dresden University of Technology, Barbara Davis Center for Childhood Diabetes (BDC), University of Colorado Anschutz [Aurora], School of Computer and Electronic Information [Guangxi University], Guangxi University [Nanning], School of Materials Science and Engineering, Nanyang Technological University [Singapour], Max Planck Institute for Infection Biology (MPIIB), Max-Planck-Gesellschaft, Work in the laboratory of Dieter Adam is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Projektnummer 125440785 – SFB 877, Project B2.Petra Hoffmann, Andrea Hauser, and Matthias Edinger thank BD Biosciences®, San José, CA, USA, and SKAN AG, Bale, Switzerland for fruitful cooperation during the development, construction, and installation of the GMP‐compliant cell sorting equipment and the Bavarian Immune Therapy Network (BayImmuNet) for financial support.Edwin van der Pol and Paola Lanuti acknowledge Aleksandra Gąsecka M.D. for excellent experimental support and Dr. Rienk Nieuwland for textual suggestions. This work was supported by the Netherlands Organisation for Scientific Research – Domain Applied and Engineering Sciences (NWO‐TTW), research program VENI 15924.Jessica G Borger, Kylie M Quinn, Mairi McGrath, and Regina Stark thank Francesco Siracusa and Patrick Maschmeyer for providing data.Larissa Nogueira Almeida was supported by DFG research grant MA 2273/14‐1. Rudolf A. Manz was supported by the Excellence Cluster 'Inflammation at Interfaces' (EXC 306/2).Susanne Hartmann and Friederike Ebner were supported by the German Research Foundation (GRK 2046).Hans Minderman was supported by NIH R50CA211108.This work was funded by the Deutsche Forschungsgemeinschaft through the grant TRR130 (project P11 and C03) to Thomas H. Winkler.Ramon Bellmàs Sanz, Jenny Kühne, and Christine S. Falk thank Jana Keil and Kerstin Daemen for excellent technical support. The work was funded by the Germany Research Foundation CRC738/B3 (CSF).The work by the Mei laboratory was supported by German Research Foundation Grant ME 3644/5‐1 and TRR130 TP24, the German Rheumatism Research Centre Berlin, European Union Innovative Medicines Initiative ‐ Joint Undertaking ‐ RTCure Grant Agreement 777357, the Else Kröner‐Fresenius‐Foundation, German Federal Ministry of Education and Research e:Med sysINFLAME Program Grant 01ZX1306B and KMU‐innovativ 'InnoCyt', and the Leibniz Science Campus for Chronic Inflammation (http://www.chronische-entzuendung.org).Axel Ronald Schulz, Antonio Cosma, Sabine Baumgart, Brice Gaudilliere, Helen M. McGuire, and Henrik E. Mei thank Michael D. Leipold for critically reading the manuscript.Christian Kukat acknowledges support from the ISAC SRL Emerging Leaders program.John Trowsdale received funding from the European Research Council under the European Union's Horizon 2020 research and innovation program (Grant Agreement 695551)., European Project: 7728036(1978), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Firenze = University of Florence (UniFI)-DENOTHE Center, Università degli Studi di Milano = University of Milan (UNIMI), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Humboldt University Of Berlin, Leibniz Research Institute for Environmental Medicine [Düsseldorf, Germany] (IUF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Universität Heidelberg [Heidelberg] = Heidelberg University, Universitäts Klinikum Freiburg = University Medical Center Freiburg (Uniklinik), University of Oxford-NIHR Biomedical Research Centre, Universität Bonn = University of Bonn, Università degli Studi di Firenze = University of Florence (UniFI), Università degli studi di Genova = University of Genoa (UniGe), Universidad de Salamanca, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Université de Lausanne = University of Lausanne (UNIL), Universität Leipzig, Universiteit Gent = Ghent University (UGENT), HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany., Cossarizza, A., Chang, H. -D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andra, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S., Barnaba, V., Barros-Martins, J., Battistini, L., Bauer, W., Baumgart, S., Baumgarth, N., Baumjohann, D., Baying, B., Bebawy, M., Becher, B., Beisker, W., Benes, V., Beyaert, R., Blanco, A., Boardman, D. A., Bogdan, C., Borger, J. G., Borsellino, G., Boulais, P. E., Bradford, J. A., Brenner, D., Brinkman, R. R., Brooks, A. E. S., Busch, D. H., Buscher, M., Bushnell, T. P., Calzetti, F., Cameron, G., Cammarata, I., Cao, X., Cardell, S. L., Casola, S., Cassatella, M. A., Cavani, A., Celada, A., Chatenoud, L., Chattopadhyay, P. K., Chow, S., Christakou, E., Cicin-Sain, L., Clerici, M., Colombo, F. S., Cook, L., Cooke, A., Cooper, A. M., Corbett, A. J., Cosma, A., Cosmi, L., Coulie, P. G., Cumano, A., Cvetkovic, L., Dang, V. D., Dang-Heine, C., Davey, M. S., Davies, D., De Biasi, S., Del Zotto, G., Dela Cruz, G. V., Delacher, M., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Di Santo, J. P., Diefenbach, A., Dieli, F., Dolf, A., Dorner, T., Dress, R. J., Dudziak, D., Dustin, M., Dutertre, C. -A., Ebner, F., Eckle, S. B. G., Edinger, M., Eede, P., Ehrhardt, G. R. A., Eich, M., Engel, P., Engelhardt, B., Erdei, A., Esser, C., Everts, B., Evrard, M., Falk, C. S., Fehniger, T. A., Felipo-Benavent, M., Ferry, H., Feuerer, M., Filby, A., Filkor, K., Fillatreau, S., Follo, M., Forster, I., Foster, J., Foulds, G. A., Frehse, B., Frenette, P. S., Frischbutter, S., Fritzsche, W., Galbraith, D. W., Gangaev, A., Garbi, N., Gaudilliere, B., Gazzinelli, R. T., Geginat, J., Gerner, W., Gherardin, N. A., Ghoreschi, K., Gibellini, L., Ginhoux, F., Goda, K., Godfrey, D. I., Goettlinger, C., Gonzalez-Navajas, J. M., Goodyear, C. S., Gori, A., Grogan, J. L., Grummitt, D., Grutzkau, A., Haftmann, C., Hahn, J., Hammad, H., Hammerling, G., Hansmann, L., Hansson, G., Harpur, C. M., Hartmann, S., Hauser, A., Hauser, A. E., Haviland, D. L., Hedley, D., Hernandez, D. C., Herrera, G., Herrmann, M., Hess, C., Hofer, T., Hoffmann, P., Hogquist, K., Holland, T., Hollt, T., Holmdahl, R., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Huang, F. -P., Huber, J. E., Huehn, J., Hundemer, M., Hunter, C. A., Hwang, W. Y. K., Iannone, A., Ingelfinger, F., Ivison, S. M., Jack, H. -M., Jani, P. K., Javega, B., Jonjic, S., Kaiser, T., Kalina, T., Kamradt, T., Kaufmann, S. H. E., Keller, B., Ketelaars, S. L. C., Khalilnezhad, A., Khan, S., Kisielow, J., Klenerman, P., Knopf, J., Koay, H. -F., Kobow, K., Kolls, J. K., Kong, W. T., Kopf, M., Korn, T., Kriegsmann, K., Kristyanto, H., Kroneis, T., Krueger, A., Kuhne, J., Kukat, C., Kunkel, D., Kunze-Schumacher, H., Kurosaki, T., Kurts, C., Kvistborg, P., Kwok, I., Landry, J., Lantz, O., Lanuti, P., Larosa, F., Lehuen, A., LeibundGut-Landmann, S., Leipold, M. D., Leung, L. Y. T., Levings, M. K., Lino, A. C., Liotta, F., Litwin, V., Liu, Y., Ljunggren, H. -G., Lohoff, M., Lombardi, G., Lopez, L., Lopez-Botet, M., Lovett-Racke, A. E., Lubberts, E., Luche, H., Ludewig, B., Lugli, E., Lunemann, S., Maecker, H. T., Maggi, L., Maguire, O., Mair, F., Mair, K. H., Mantovani, A., Manz, R. A., Marshall, A. J., Martinez-Romero, A., Martrus, G., Marventano, I., Maslinski, W., Matarese, G., Mattioli, A. V., Maueroder, C., Mazzoni, A., Mccluskey, J., Mcgrath, M., Mcguire, H. M., Mcinnes, I. B., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Miller, S. D., Mills, K. H. G., Minderman, H., Mjosberg, J., Moore, J., Moran, B., Moretta, L., Mosmann, T. R., Muller, S., Multhoff, G., Munoz, L. E., Munz, C., Nakayama, T., Nasi, M., Neumann, K., Ng, L. G., Niedobitek, A., Nourshargh, S., Nunez, G., O'Connor, J. -E., Ochel, A., Oja, A., Ordonez, D., Orfao, A., Orlowski-Oliver, E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Pattanapanyasat, K., Paulsen, M., Pavlinic, D., Penter, L., Peterson, P., Peth, C., Petriz, J., Piancone, F., Pickl, W. F., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Poon, Z., Pracht, K., Prinz, I., Pucillo, C. E. M., Quataert, S. A., Quatrini, L., Quinn, K. M., Radbruch, H., Radstake, T. R. D. J., Rahmig, S., Rahn, H. -P., Rajwa, B., Ravichandran, G., Raz, Y., Rebhahn, J. A., Recktenwald, D., Reimer, D., Reis e Sousa, C., Remmerswaal, E. B. M., Richter, L., Rico, L. G., Riddell, A., Rieger, A. M., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Saalmuller, A., Saeys, Y., Saito, T., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sandrock, I., Santoni, A., Sanz, R. B., Saresella, M., Sautes-Fridman, C., Sawitzki, B., Schadt, L., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schimisky, E., Schlitzer, A., Schlosser, J., Schmid, S., Schmitt, S., Schober, K., Schraivogel, D., Schuh, W., Schuler, T., Schulte, R., Schulz, A. R., Schulz, S. R., Scotta, C., Scott-Algara, D., Sester, D. P., Shankey, T. V., Silva-Santos, B., Simon, A. K., Sitnik, K. M., Sozzani, S., Speiser, D. E., Spidlen, J., Stahlberg, A., Stall, A. M., Stanley, N., Stark, R., Stehle, C., Steinmetz, T., Stockinger, H., Takahama, Y., Takeda, K., Tan, L., Tarnok, A., Tiegs, G., Toldi, G., Tornack, J., Traggiai, E., Trebak, M., Tree, T. I. M., Trotter, J., Trowsdale, J., Tsoumakidou, M., Ulrich, H., Urbanczyk, S., van de Veen, W., van den Broek, M., van der Pol, E., Van Gassen, S., Van Isterdael, G., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H. -D., von Borstel, A., von Volkmann, K., Waisman, A., Walker, R. V., Wallace, P. K., Wang, S. A., Wang, X. M., Ward, M. D., Ward-Hartstonge, K. A., Warnatz, K., Warnes, G., Warth, S., Waskow, C., Watson, J. V., Watzl, C., Wegener, L., Weisenburger, T., Wiedemann, A., Wienands, J., Wilharm, A., Wilkinson, R. J., Willimsky, G., Wing, J. B., Winkelmann, R., Winkler, T. H., Wirz, O. F., Wong, A., Wurst, P., Yang, J. H. M., Yang, J., Yazdanbakhsh, M., Yu, L., Yue, A., Zhang, H., Zhao, Y., Ziegler, S. M., Zielinski, C., Zimmermann, J., Zychlinsky, A., UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/GECE - Génétique cellulaire, Netherlands Organization for Scientific Research, German Research Foundation, European Commission, European Research Council, Repositório da Universidade de Lisboa, CCA - Imaging and biomarkers, Experimental Immunology, AII - Infectious diseases, AII - Inflammatory diseases, Biomedical Engineering and Physics, ACS - Atherosclerosis & ischemic syndromes, and Landsteiner Laboratory
Subjects: 0301 basic medicine, Consensus, Immunology, Consensu, Cell Separation, Biology, Article, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, Guidelines, Allergy and Immunology, medicine, Cell separation, Immunology and Allergy, Humans, guidelines, flow cytometry, immunology, medicine.diagnostic_test, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences, Cell sorting, Flow Cytometry, Cell selection, Data science, 3. Good health, 030104 developmental biology, Phenotype, [SDV.IMM]Life Sciences [q-bio]/Immunology, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti, 030215 immunology, Human
Abstract: All authors: Andrea Cossarizza Hyun‐Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam‐Klages William W. Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Francesco Annunziato Achille Anselmo Petra Bacher Cosima T. Baldari Sudipto Bari Vincenzo Barnaba Joana Barros‐Martins Luca Battistini Wolfgang Bauer Sabine Baumgart Nicole Baumgarth Dirk Baumjohann Bianka Baying Mary Bebawy Burkhard Becher Wolfgang Beisker Vladimir Benes Rudi Beyaert Alfonso Blanco Dominic A. Boardman Christian Bogdan Jessica G. Borger Giovanna Borsellino Philip E. Boulais Jolene A. Bradford Dirk Brenner Ryan R. Brinkman Anna E. S. Brooks Dirk H. Busch Martin Büscher Timothy P. Bushnell Federica Calzetti Garth Cameron Ilenia Cammarata Xuetao Cao Susanna L. Cardell Stefano Casola Marco A. Cassatella Andrea Cavani Antonio Celada Lucienne Chatenoud Pratip K. Chattopadhyay Sue Chow Eleni Christakou Luka Čičin‐Šain Mario Clerici Federico S. Colombo Laura Cook Anne Cooke Andrea M. Cooper Alexandra J. Corbett Antonio Cosma Lorenzo Cosmi Pierre G. Coulie Ana Cumano Ljiljana Cvetkovic Van Duc Dang Chantip Dang‐Heine Martin S. Davey Derek Davies Sara De Biasi Genny Del Zotto Gelo Victoriano Dela Cruz Michael Delacher Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing James P. Di Santo Andreas Diefenbach Francesco Dieli Andreas Dolf Thomas Dörner Regine J. Dress Diana Dudziak Michael Dustin Charles‐Antoine Dutertre Friederike Ebner Sidonia B. G. Eckle Matthias Edinger Pascale Eede Götz R.A. Ehrhardt Marcus Eich Pablo Engel Britta Engelhardt Anna Erdei Charlotte Esser Bart Everts Maximilien Evrard Christine S. Falk Todd A. Fehniger Mar Felipo‐Benavent Helen Ferry Markus Feuerer Andrew Filby Kata Filkor Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A. Foulds Britta Frehse Paul S. Frenette Stefan Frischbutter Wolfgang Fritzsche David W. Galbraith Anastasia Gangaev Natalio Garbi Brice Gaudilliere Ricardo T. Gazzinelli Jens Geginat Wilhelm Gerner Nicholas A. Gherardin Kamran Ghoreschi Lara Gibellini Florent Ginhoux Keisuke Goda Dale I. Godfrey Christoph Goettlinger Jose M. González‐Navajas Carl S. Goodyear Andrea Gori Jane L. Grogan Daryl Grummitt Andreas Grützkau Claudia Haftmann Jonas Hahn Hamida Hammad Günter Hämmerling Leo Hansmann Goran Hansson Christopher M. Harpur Susanne Hartmann Andrea Hauser Anja E. Hauser David L. Haviland David Hedley Daniela C. Hernández Guadalupe Herrera Martin Herrmann Christoph Hess Thomas Höfer Petra Hoffmann Kristin Hogquist Tristan Holland Thomas Höllt Rikard Holmdahl Pleun Hombrink Jessica P. Houston Bimba F. Hoyer Bo Huang Fang‐Ping Huang Johanna E. Huber Jochen Huehn Michael Hundemer Christopher A. Hunter William Y. K. Hwang Anna Iannone Florian Ingelfinger Sabine M Ivison Hans‐Martin Jäck Peter K. Jani Beatriz Jávega Stipan Jonjic Toralf Kaiser Tomas Kalina Thomas Kamradt Stefan H. E. Kaufmann Baerbel Keller Steven L. C. Ketelaars Ahad Khalilnezhad Srijit Khan Jan Kisielow Paul Klenerman Jasmin Knopf Hui‐Fern Koay Katja Kobow Jay K. Kolls Wan Ting Kong Manfred Kopf Thomas Korn Katharina Kriegsmann Hendy Kristyanto Thomas Kroneis Andreas Krueger Jenny Kühne Christian Kukat Désirée Kunkel Heike Kunze‐Schumacher Tomohiro Kurosaki Christian Kurts Pia Kvistborg Immanuel Kwok Jonathan Landry Olivier Lantz Paola Lanuti Francesca LaRosa Agnès Lehuen Salomé LeibundGut‐Landmann Michael D. Leipold Leslie Y.T. Leung Megan K. Levings Andreia C. Lino Francesco Liotta Virginia Litwin Yanling Liu Hans‐Gustaf Ljunggren Michael Lohoff Giovanna Lombardi Lilly Lopez Miguel López‐Botet Amy E. Lovett‐Racke Erik Lubberts Herve Luche Burkhard Ludewig Enrico Lugli Sebastian Lunemann Holden T. Maecker Laura Maggi Orla Maguire Florian Mair Kerstin H. Mair Alberto Mantovani Rudolf A. Manz Aaron J. Marshall Alicia Martínez‐Romero Glòria Martrus Ivana Marventano Wlodzimierz Maslinski Giuseppe Matarese Anna Vittoria Mattioli Christian Maueröder Alessio Mazzoni James McCluskey Mairi McGrath Helen M. McGuire Iain B. McInnes Henrik E. Mei Fritz Melchers Susanne Melzer Dirk Mielenz Stephen D. Miller Kingston H.G. Mills Hans Minderman Jenny Mjösberg Jonni Moore Barry Moran Lorenzo Moretta Tim R. Mosmann Susann Müller Gabriele Multhoff Luis Enrique Muñoz Christian Münz Toshinori Nakayama Milena Nasi Katrin Neumann Lai Guan Ng Antonia Niedobitek Sussan Nourshargh Gabriel Núñez José‐Enrique O'Connor Aaron Ochel Anna Oja Diana Ordonez Alberto Orfao Eva Orlowski‐Oliver Wenjun Ouyang Annette Oxenius Raghavendra Palankar Isabel Panse Kovit Pattanapanyasat Malte Paulsen Dinko Pavlinic Livius Penter Pärt Peterson Christian Peth Jordi Petriz Federica Piancone Winfried F. Pickl Silvia Piconese Marcello Pinti A. Graham Pockley Malgorzata Justyna Podolska Zhiyong Poon Katharina Pracht Immo Prinz Carlo E. M. Pucillo Sally A. Quataert Linda Quatrini Kylie M. Quinn Helena Radbruch Tim R. D. J. Radstake Susann Rahmig Hans‐Peter Rahn Bartek Rajwa Gevitha Ravichandran Yotam Raz Jonathan A. Rebhahn Diether Recktenwald Dorothea Reimer Caetano Reis e Sousa Ester B.M. Remmerswaal Lisa Richter Laura G. Rico Andy Riddell Aja M. Rieger J. Paul Robinson Chiara Romagnani Anna Rubartelli Jürgen Ruland Armin Saalmüller Yvan Saeys Takashi Saito Shimon Sakaguchi Francisco Sala‐de‐Oyanguren Yvonne Samstag Sharon Sanderson Inga Sandrock Angela Santoni Ramon Bellmàs Sanz Marina Saresella Catherine Sautes‐Fridman Birgit Sawitzki Linda Schadt Alexander Scheffold Hans U. Scherer Matthias Schiemann Frank A. Schildberg Esther Schimisky Andreas Schlitzer Josephine Schlosser Stephan Schmid Steffen Schmitt Kilian Schober Daniel Schraivogel Wolfgang Schuh Thomas Schüler Reiner Schulte Axel Ronald Schulz Sebastian R. Schulz Cristiano Scottá Daniel Scott‐Algara David P. Sester T. Vincent Shankey Bruno Silva‐Santos Anna Katharina Simon Katarzyna M. Sitnik Silvano Sozzani Daniel E. Speiser Josef Spidlen Anders Stahlberg Alan M. Stall Natalie Stanley Regina Stark Christina Stehle Tobit Steinmetz Hannes Stockinger Yousuke Takahama Kiyoshi Takeda Leonard Tan Attila Tárnok Gisa Tiegs Gergely Toldi Julia Tornack Elisabetta Traggiai Mohamed Trebak Timothy I.M. Tree Joe Trotter John Trowsdale Maria Tsoumakidou Henning Ulrich Sophia Urbanczyk Willem van de Veen Maries van den Broek Edwin van der Pol Sofie Van Gassen Gert Van Isterdael René A.W. van Lier Marc Veldhoen Salvador Vento‐Asturias Paulo Vieira David Voehringer Hans‐Dieter Volk Anouk von Borstel Konrad von Volkmann Ari Waisman Rachael V. Walker Paul K. Wallace Sa A. Wang Xin M. Wang Michael D. Ward Kirsten A Ward‐Hartstonge Klaus Warnatz Gary Warnes Sarah Warth Claudia Waskow James V. Watson Carsten Watzl Leonie Wegener Thomas Weisenburger Annika Wiedemann Jürgen Wienands Anneke Wilharm Robert John Wilkinson Gerald Willimsky James B. Wing Rieke Winkelmann Thomas H. Winkler Oliver F. Wirz Alicia Wong Peter Wurst Jennie H. M. Yang Juhao Yang Maria Yazdanbakhsh Liping Yu Alice Yue Hanlin Zhang Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky., These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer‐reviewed by leading experts in the field, making this an essential research companion., This work was supported by the Netherlands Organisation for Scientific Research – Domain Applied and Engineering Sciences (NWO-TTW), research program VENI 15924. This work was funded by the Deutsche Forschungsgemeinschaft. European Union Innovative Medicines Initiative - Joint Undertaking - RTCure Grant Agreement 777357 and innovation program (Grant Agreement 695551).
Published: 2019

19. Proceedings of the signature series symposium 'cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies—promise, facts and fantasy,' international society for cellular therapies, montreal, canada, may 2, 2018

Author: Frank Barry, Ivan Martin, Thomas W. Bauer, Cecilia Pascual-Garrido, Christian Jorgensen, Scott A. Rodeo, George F. Muschler, Constance R. Chu, Jérôme Guicheux, Pamela Gehron Robey, Nicolas S. Piuzzi, Massimo Dominici, Stéphane Maddens, M. A.R.C. Long, J. O.H.N. Barrett, David Karli, Richard McFarland, Johnny Huard, Laurie R. Goodrich, Daniel J. Weiss, Department of Orthopedic Surgery [Cleveland, Ohio, USA], Cleveland Clinic, Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Department of Medical and Surgical Sciences for Children and Adults [Modena, Italy] (Laboratory of Cellular Therapy), Università degli Studi di Modena e Reggio Emilia (UNIMORE), MTF Biologics, Edison [New Jersey, USA], Adult Reconstruction-Adolescent and Young Adult Hip Service [St. Louis, Missouri, USA] (School of Medicine), Washington University in Saint Louis (WUSTL), Orthopaedic Soft Tissue Research Program [New York, NY, USA], Hospital for Special Surgery, Department of Orthopaedic Surgery [Houston, TX, USA], The University of Texas Health Science Center at Houston (UTHealth), Steadman Philippon Research Institute, Regenerative Medicine and Skeleton research lab (RMeS), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale [CHU Nantes] (PHU4 - OTONN), Centre hospitalier universitaire de Nantes (CHU Nantes), Advanced Regenerative Manufacturing Institute [Manchester, NH, USA], Standards Coordinating Body, Department of Clinical Sciences [Fort Collins, CO, USA] (Orthopaedic Research Center), Colorado State University [Fort Collins] (CSU), Vetbiobank [Marcy l’Etoile, France], Department of Health and Human Services [Bethesda, MD, USA] (Skeletal Biology Section ), National Institutes of Health [Bethesda] (NIH), Department of Pathology and Laboratory Medicine [New-York, NY, USA], Stem Cell Allogeneic Transplant Section [Bethesda, MD, USA], Regenerative Medicine Institute [Galway, Ireland], National University of Ireland [Galway] (NUI Galway), Greyledge Technologies - LLC [Vail, CO, USA], Department of Orthopaedic Surgery [Stanford], Stanford Medicine, Stanford University-Stanford University, Veterans Affairs Palo Alto Health Care System [Palo Alto, CA, USA], University of Vermont [Burlington], Department of Biomedicine [Basel], University Hospital Basel [Basel], Unité thérapeutique d'immunologie clinique et des maladies ostéoarticulaires [Hôpital Lapeyronie, Montpellier], Hôpital Lapeyronie [Montpellier] (CHU), The authors thanks both the ISCT and the sponsors of the First Signature Series Symposium 'Cellular Therapies for Orthopaedics and Musculoskeletal Disease Proven and Unproven Therapies–Promise, Facts and Fantasy,' May 2, 2018, Montreal, Canada: Greyledge Technologies (Edwards, Colorado), MTF Biologics (Edison, New Jersey), Orthofix (Lewisville, Texas), MEdXcell (Lausanne, Switzerland), Osiris Therapeutics (Columbia, Maryland) and Angiocrine Bioscience (San Diego, California). Additionally this work was supported, in part, by the DIR, NIDCR, a part of the Intramural Research Program (IRP), NIH, DHHS (to P.G.R., ZIA DE000380)., Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Regenerative Medicine and Skeleton (RMeS), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Jehan, Frederic, Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and University of Vermont College of Medicine [Burlington, VT, USA]
Subjects: Immunology and Allergy, Immunology, Oncology, Genetics (clinical), Cell Biology, Transplantation, Cancer Research, 0301 basic medicine, medicine.medical_specialty, education, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Fantasy, Misinformation, health care economics and organizations, Confusion, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, 030222 orthopedics, Government, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, business.industry, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Musculoskeletal disease, humanities, 3. Good health, 030104 developmental biology, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Orthopedic surgery, Engineering ethics, medicine.symptom, business
Abstract: International audience; The Signature Series Symposium "Cellular Therapies for Orthopaedics and Musculoskeletal Disease Proven and Unproven Therapies-Promise, Facts and Fantasy" was held as a pre-meeting of the 26th International Society for Cellular Therapy (ISCT) annual congress in Montreal, Canada, May 2, 2018. This was the first ISCT program that was entirely dedicated to the advancement of cell-based therapies for musculoskeletal diseases. Cellular therapies in musculoskeletal medicine are a source of great promise and opportunity. They are also the source of public controversy, confusion and misinformation. Patients, clinicians, scientists, industry and government share a commitment to clear communication and responsible development of the field. Therefore, this symposium convened thought leaders from around the world in a forum designed to catalyze communication and collaboration to bring the greatest possible innovation and value to patients with musculoskeletal conditions.
Published: 2018

20. Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor

Author: Tiago, Tatiana, Hummel, Barbara, Morelli, Federica F, Basile, Valentina, Vinet, Jonathan, Galli, Veronica, Mediani, Laura, Antoniani, Francesco, Pomella, Silvia, Cassandri, Matteo, Garone, Maria Giovanna, Silvestri, Beatrice, Cimino, Marco, Cenacchi, Giovanna, Costa, Roberta, Mouly, Vincent, Poser, Ina, Yeger-Lotem, Esti, Rosa, Alessandro, Alberti, Simon, Rota, Rossella, Ben-Zvi, Anat, Sawarkar, Ritwick, Carra, Serena, UMRS974, Université Pierre et Marie Curie - Paris 6 (UPMC), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Max-Planck-Gesellschaft, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], University of Bologna, Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Ben-Gurion University of the Negev (BGU), Technische Universität Dresden = Dresden University of Technology (TU Dresden), University of Cambridge [UK] (CAM), Centre de Recherche en Myologie, Tiago, Tatiana [0000-0001-9290-248X], Pomella, Silvia [0000-0002-7007-4238], Cenacchi, Giovanna [0000-0001-5824-3118], Costa, Roberta [0000-0002-2884-6716], Yeger-Lotem, Esti [0000-0002-8279-7898], Rosa, Alessandro [0000-0001-9999-7223], Alberti, Simon [0000-0003-4017-6505], Rota, Rossella [0000-0002-9408-7711], Ben-Zvi, Anat [0000-0003-2477-6519], Carra, Serena [0000-0003-0939-0140], Apollo - University of Cambridge Repository, Tiago T., Hummel B., Morelli F.F., Basile V., Vinet J., Galli V., Mediani L., Antoniani F., Pomella S., Cassandri M., Garone M.G., Silvestri B., Cimino M., Cenacchi G., Costa R., Mouly V., Poser I., Yeger-Lotem E., Rosa A., Alberti S., Rota R., Ben-Zvi A., Sawarkar R., and Carra S.
Subjects: Cell biology, Molecular biology, Receptors, Cytoplasmic and Nuclear, 13/106, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], HeLa Cell, Muscle Development, Transfection, Settore MED/05, Article, Cell Line, molecular biology, myogenesis, HSPB3, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, 14/19, Muscle, Skeletal, Heat-Shock Proteins, 45/91, QH573-671, Heat-Shock Protein, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, 96/63, 3. Good health, Heat-Shock Proteins, Small, 631/80, Cytology, 631/337, Human, HeLa Cells
Abstract: International audience; Abstract One of the critical events that regulates muscle cell differentiation is the replacement of the lamin B receptor (LBR)-tether with the lamin A/C (LMNA)-tether to remodel transcription and induce differentiation-specific genes. Here, we report that localization and activity of the LBR-tether are crucially dependent on the muscle-specific chaperone HSPB3 and that depletion of HSPB3 prevents muscle cell differentiation. We further show that HSPB3 binds to LBR in the nucleoplasm and maintains it in a dynamic state, thus promoting the transcription of myogenic genes, including the genes to remodel the extracellular matrix. Remarkably, HSPB3 overexpression alone is sufficient to induce the differentiation of two human muscle cell lines, LHCNM2 cells, and rhabdomyosarcoma cells. We also show that mutant R116P-HSPB3 from a myopathy patient with chromatin alterations and muscle fiber disorganization, forms nuclear aggregates that immobilize LBR. We find that R116P-HSPB3 is unable to induce myoblast differentiation and instead activates the unfolded protein response. We propose that HSPB3 is a specialized chaperone engaged in muscle cell differentiation and that dysfunctional HSPB3 causes neuromuscular disease by deregulating LBR.
Published: 2021

21. Circularly-polarized CTS Array Antenna for SatCom applications

Author: Luca Vincetti, Mauro Ettorre, Michele Del Mastro, Stefano Lenzini, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Lenzini S., Del Mastro M., Vincetti L., Ettorre M., Nantes Université (NU)-Université de Rennes 1 (UR1), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics, Pillbox system, business.industry, Axial ratio, Continuous transverse stub array, Circular polarization, SatCom applications, Bandwidth (signal processing), 020206 networking & telecommunications, 02 engineering and technology, 7. Clean energy, Stub (electronics), Transverse plane, [SPI]Engineering Sciences [physics], Optics, Electric field, Excited state, 0202 electrical engineering, electronic engineering, information engineering, Antenna (radio), business
Abstract: International audience; This paper proposes a circularly-polarized continuous transverse stub(CTS) array antenna for space applications. The radiating structure consists of open-ended parallel plate waveguides(PPW), supporting the propagation of the transverse electromagnetic(TEM) and first transverse electric(TE1) modes. Such modes are orthogonally-polarized in the PPW cross-section and, if properly excited, can generate circular polarization(CP). The antenna radiating section consists of 32 long slots, parallel-fed by a quasi-optical system through a PPW-based corporate feed network(CFN) and an electric field rotator. The proposed antenna is matched in the 27.5-31GHz band while scanning up to +-20° in elevation, with an axial ratio(AR) below 3dB. © 2021 IEICE.
Published: 2021

22. On the setting of scales in the diachrony of differential object marking

Author: Irimia, Monica Alexandrina, Pineda, Anna, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Sorbonne Université - Faculté des Lettres - UFR de Langue française (SU UFR LF), and Sorbonne Université (SU)
Subjects: [SHS.LANGUE]Humanities and Social Sciences/Linguistics
Abstract: International audience; The focus of this paper is a generally ignored counterexample to animacy/person scales (Hale 1972, Silverstein 1976, Aissen 2003, a.o.), which are often assumed to be universal (Kiparsky 2008, a.o.). Drawing from Old Romance differential object marking (DOM) data, we analyse various scale reversals in Old Catalan and Old Romanian. We notice that, contrary to what the scales would predict, i) 3 rd person pronouns surface with DOM to the exclusion of 1 st and 2 nd persons, and ii) proper names take DOM to the exclusion of pronouns. We propose to derive these unexpected patterns by evaluating i) micro-parameters in the composition of Romance DPs and pronouns, and ii) the presence of more than one licensing strategy for arguments. Scale reversals result from the introduction of a novel argumentlicensing strategy based on animacy in languages where an older strategy for 1 st /2 nd persons was still active.
Published: 2021

23. Determinants of therapeutic lag in multiple sclerosis

Author: Tomas Kalincik, Marc Girard, Corinne Pottier, Murat Terzi, Jean Pelletier, Oliver Gerlach, Julie Prevost, Dana Horakova, Francois Grand'Maison, Raed Alroughani, Guillermo Izquierdo, Francesco Patti, Federico Frascoli, Maria Trojano, Franco Granella, Pamela A. McCombe, Charles B Malpas, Recai Turkoglu, Aurélie Ruet, Jonathan Ciron, Tünde Csépány, Nicolas Maubeuge, Helmut Butzkueven, Pierre Clavelou, Tamara Castillo Trivino, Marco Onofrj, Jean Philippe Camdessanche, Pierre Labauge, Vincent Van Pesch, Pierre Grammond, Abir Wahab, Roberto Bergamaschi, Aysun Soysal, Diana Ferraro, Bertrand Bourre, Olivier Gout, Jeannette Lechner-Scott, Sara Eichau, Emmanuelle Leray, Alexis Montcuquet, Pierre Duquette, Olivier Casez, Youssef Sidhom, Patrizia Sola, Bart Van Wijmeersch, Izanne Roos, Gilles Edan, Serkan Ozakbas, David Laplaud, Sandra Vukusic, Abdullatif Al Khedr, Céline Labeyrie, Philippe Cabre, Eric Thouvenot, Céline Louapre, Romain Casey, Alessandra Lugaresi, Riadh Gouider, Alasdair Coles, Eric Berger, Ivania Patry, Gerardo Iuliano, Elisabetta Cartechini, Cavit Boz, Karolina Hankiewicz, Eva Havrdova, Eduardo Aguera-Morales, J William L Brown, Jérôme De Seze, Bruno Stankoff, Olivier Heinzlef, Gilles Defer, Alexandre Prat, Chantal Nifle, Maria José Sá, Marc Debouverie, Daniele Spitaleri, Aude Maurousset, Thibault Moreau, Christine Lebrun-Frenay, Hélène Zéphir, University of Melbourne, Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Collectif de recherche handicap, autonomie et société inclusive (CoRHASI), Swinburne University of Technology [Melbourne], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Charles University [Prague], Università degli studi di Catania [Catania], Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Università degli Studi di Modena e Reggio Emilia (UNIMORE), University of Queensland [Brisbane], Monash University [Clayton], UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de neurologie, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Charles University [Prague] (CU), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), University of Bari Aldo Moro (UNIBA), University of Catania [Italy], Hospital Virgen Macarena, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), CHU Toulouse [Toulouse], INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA)-Hôpital de Hautepierre [Strasbourg]-Nouvel Hôpital Civil de Strasbourg, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Lille, Fernando Pessoa University, Azienda Ospedaleria Universitaria di Modena, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Universitaire de Nice (CHU Nice), Karadeniz Technical University (KTU), Università degli Studi di Macerata = University of Macerata (UNIMC), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), University of Newcastle [Australia] (UoN), Zuyderland Hospital [Heerlen, The Netherlands], Ondokuz Mayis University, University of Parma = Università degli studi di Parma [Parme, Italie], Amiri hospital, University of Salerno (UNISA), Université Catholique de Louvain = Catholic University of Louvain (UCL), Hasselt University (UHasselt), San Giuseppe Moscati Hospital [Avellino, Italie], Bakirkoy Matern & Childrens State Hosp, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Universidad de Córdoba [Cordoba], Hospital Donostia, CHU Clermont-Ferrand, Hôpital de la Timone [CHU - APHM] (TIMONE), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHI Poissy-Saint-Germain, Université de la Manouba [Tunisie] (UMA), University of Debrecen, Hôpital Charles Nicolle [Rouen], CHU Amiens-Picardie, CHU de la Martinique [Fort de France], CHU Limoges, CHU Henri Mondor, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier Sud Francilien, CH Evry-Corbeil, Centre Hospitalier de Saint-Denis [Ile-de-France], Centre Hospitalier René Dubos [Pontoise], This study was supported by the EDMUS Foundation and NHMRC [1140766,1129189, 1157717]. IR is supported by a MSIF-ARSEP McDonald fellowship grantand a Melbourne Research Scholarship. The MSBase Foundation is a not-for-profitorganization that receives support from Biogen, Novartis, Merck, Roche, Teva andSanofi Genzyme. The study was conducted separately and apart from the guidanceof the sponsors. The Observatoire Français de la Sclérose en Plaques (OFSEP) issupported by a grant provided by the French State and handled by the 'AgenceNationale de la Recherche,' within the framework of the 'Investments for the Future'program, under the reference ANR-10-COHO-002, by the Eugène Devic EDMUSFoundation against multiple sclerosis and by the ARSEP Foundation., ANR-10-COHO-0002,OFSEP,Observatoire Français de la Sclérose en Plaques(2010), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Roos I., Leray E., Frascoli F., Casey R., Brown J.W.L., Horakova D., Havrdova E.K., Debouverie M., Trojano M., Patti F., Izquierdo G., Eichau S., Edan G., Prat A., Girard M., Duquette P., Onofrj M., Lugaresi A., Grammond P., Ciron J., Ruet A., Ozakbas S., De Seze J., Louapre C., Zephir H., Sa M.J., Sola P., Ferraro D., Labauge P., Defer G., Bergamaschi R., Lebrun-Frenay C., Boz C., Cartechini E., Moreau T., Laplaud D., Lechner-Scott J., Grand'Maison F., Gerlach O., Terzi M., Granella F., Alroughani R., Iuliano G., Van Pesch V., Van Wijmeersch B., Spitaleri D.L.A., Soysal A., Berger E., Prevost J., Aguera-Morales E., McCombe P., Castillo Trivino T., Clavelou P., Pelletier J., Turkoglu R., Stankoff B., Gout O., Thouvenot E., Heinzlef O., Sidhom Y., Gouider R., Csepany T., Bourre B., Al Khedr A., Casez O., Cabre P., Montcuquet A., Wahab A., Camdessanche J.-P., Maurousset A., Patry I., Hankiewicz K., Pottier C., Maubeuge N., Labeyrie C., Nifle C., Coles A., Malpas C.B., Vukusic S., Butzkueven H., Kalincik T., Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Università degli studi di Catania = University of Catania (Unict), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), University of Newcastle [Callaghan, Australia] (UoN), Ondokuz Mayis University (OMU), Università degli studi di Parma = University of Parma (UNIPR), Universidad de Córdoba = University of Córdoba [Córdoba], University of Debrecen Egyetem [Debrecen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), CHU Henri Mondor [Créteil], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Registrie, Male, medicine.medical_specialty, Treatment response, Pediatrics, Neurology, Lag, [SDV]Life Sciences [q-bio], Aucun, multiple sclerosis, 03 medical and health sciences, Disability Evaluation, 0302 clinical medicine, Multiple Sclerosis, Relapsing-Remitting, Recurrence, medicine, Humans, Treatment effect, Disabled Persons, Registries, 030304 developmental biology, 0303 health sciences, business.industry, Multiple sclerosis, Delayed onset, medicine.disease, 3. Good health, Clinical neurology, therapeutic lag, multiple sclerosi, Disease Progression, Disabled Person, Observational study, Female, observational study, Neurology (clinical), business, 030217 neurology & neurosurgery, Human
Abstract: International audience; Objective: To explore the associations of patient and disease characteristics with the duration of therapeutic lag for relapses and disability progression.Background: Therapeutic lag represents the delay from initiation of therapy to attainment of full treatment effect. Understanding the determinants of therapeutic lag provides valuable information for personalised choice of therapy in multiple sclerosis (MS).Design/Methods: Data from MSBase, a multinational MS registry, and OFSEP, the French national registry, were used. Patients diagnosed with MS, minimum 1-year exposure to MS treatment, minimum 3-year pre-treatment follow up and yearly review were included in the analysis. By studying incidence of relapses and 6-month confirmed disability progression, the duration of therapeutic lag was calculated by identifying the first local minimum of the first derivative after treatment start in subgroups stratified by patient and disease characteristics. Pairwise analyses of univariate predictors were performed. Combinations of determinants that consistently drove differences in therapeutic lag in pair by pair analyses were included in the final model.Results: Baseline EDSS, ARR and sex were associated with duration of therapeutic lag on disability progression in univariate and pairwise bivariable analyses. In the final model, therapeutic lag was 27.8 weeks shorter in females with ARR6 compared to those with EDSS>=6 (26.6, 18.2–34.9 vs 54.3, 47.2–61.5). Baseline EDSS, ARR, sex and MS phenotype were associated with duration of therapeutic lag on relapses in univariate analyses. Pairwise bivariable analyses of the pairs of determinants suggested ependently associated with therapeutic lag. In the final model, therapeutic lag was shortest in those with RRMS and EDSS
Published: 2021

24. Experimental and Ab Initio Characterization of Mononuclear Molybdenum Dithiocarbamates in Lubricant Mixtures

Author: Franck Delayens, Hervé Vezin, Benoit Thiebaut, Gabriele Losi, Sophie Loehlé, Maria Clelia Righi, Stefan Peeters, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Università degli Studi di Modena e Reggio Emilia (UNIMORE), TOTAL Marketing Services, TOTAL, Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille Institut (CLIL), Losi, Gabriele, Peeters, Stefan, Delayens, Franck, Vezin, Hervé, Loehlé, Sophie, Thiebaut, Benoit, Righi, Maria Clelia, Université de Lille, CNRS, Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 [LASIRE], Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), and Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: lubricant additive, Chemical structure, tribochemistry, Iron, Kinetics, Electrical energy, Ab initio, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, DFT, Dissociation (chemistry), Fragmentation, Mixtures, Article, chemistry.chemical_compound, MoDTC, Electrochemistry, Molecule, General Materials Science, Lubricant, Molybdenum disulfide, Spectroscopy, electronic propertie, Surfaces and Interfaces, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, chemistry, Chemical engineering, Molybdenum, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], 0210 nano-technology
Abstract: International audience; Molybdenum dithiocarbamates (MoDTCs) are a class of lubricant additives widely employed in automotives. Most of the studies concerning MoDTC take into account the dimeric structures because of their industrial relevance, with the mononuclear compounds usually neglected, because isolating and characterizing subgroups of MoDTC molecules are generally difficult. However, the byproducts of the synthesis of MoDTC can impact the friction reduction performance at metallic interfaces, and the effect of mononuclear MoDTC (mMoDTC) compounds in the lubrication has not been considered yet in the literature. In this study, we consider for the first time the impurities of MoDTC consisting of mononuclear compounds and combine experimental and computational techniques to elucidate the interaction of these impurities with binuclear MoDTC in commercial formulations. We present a preliminary strategy to separate a commercial MoDTC product in chemically different fractions. These fractions present different tribological behaviors depending on the relative amount of mononuclear and binuclear complexes. The calculations indicate that the dissociation mechanism of mMoDTC is similar to the one observed for the dimeric structures. However, the different chemical properties of mMoDTC impact the kinetics for the formation of the beneficial molybdenum disulfide (MoS2) layers, as shown by the tribological experiments. These results help to understand the functionality of MoDTC lubricant additives, providing new insights into the complex synergy between the different chemical structures.
Published: 2021

25. GaN-based power devices: Physics, reliability, and perspectives

Author: Gaudenzio Meneghesso, Idriss Abid, Carlo De Santi, Giovanni Verzellesi, Alessandro Chini, Marcello Cioni, Luca Nela, Enrico Zanoni, Nicolo Zagni, Riyaz Abdul Khadar, Matteo Meneghini, Farid Medjdoub, Matteo Buffolo, Elison Matioli, Universita degli Studi di Padova, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Ecole Polytechnique Fédérale de Lausanne (EPFL), Università degli Studi di Padova = University of Padua (Unipd), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), WIde baNd gap materials and Devices - IEMN (WIND - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), This activity received funding partially from the ECSEL Joint Undertaking (JU) under Grant Agreement No 826392, UltimateGaN. The JU receives support from the European Union's Horizon 2020 Research and Innovation Programme and Austria, Belgium, Germany, Italy, Slovakia, Spain, Sweden, Norway, and Switzerland. This project was co-funded by the Ministry of Education, Universities and Research, in Italy. This activity also received funding partially from the ECSEL Joint Undertaking (JU) through the iRel40 Project. iRel40 is a European co-funded innovation project that has been granted by the ECSEL Joint Undertaking (JU) under Grant Agreement No. 876659. The funding of the project comes from the Horizon 2020 Research Programme and participating countries. National funding was provided by Germany, including the Free States of Saxony and Thuringia, Austria, Belgium, Finland, France, Italy, the Netherlands, Slovakia, Spain, Sweden, and Turkey. This project was co-funded by the Ministry of Economic Development in Italy. This work has received funding partially from the ECSEL Joint Undertaking (JU) within the YESvGaN Project under Grant Agreement No. 101007229. The JU receives support from the European Union's Horizon 2020 Research and Innovation Programme and Germany, France, Belgium, Austria, Sweden, Spain, and Italy. This project is co-funded by the Ministry of Education, Universities and Research in Italy., PCMP CHOP, Renatech Network, and European Project: 101007229,H2020,H2020-ECSEL-2020-2-RIA-two-stage,YESvGaN(2021)
Subjects: off-state degradation, dynamic-r-on, General Physics and Astronomy, Gallium nitride, 02 engineering and technology, 7. Clean energy, 01 natural sciences, law.invention, chemistry.chemical_compound, Reliability (semiconductor), electron-mobility transistors, law, 0103 physical sciences, Miniaturization, Power semiconductor device, Electronics, n-type gan, 010302 applied physics, Physics, schottky-barrier diodes, drain current dlts, business.industry, field-effect transistors, Transistor, Saturation velocity, high breakdown voltage, 021001 nanoscience & nanotechnology, Engineering physics, [SPI.TRON]Engineering Sciences [physics]/Electronics, deep-level defects, Semiconductor, chemistry, natural super junction, 0210 nano-technology, business
Abstract: International audience; Over the last decade, gallium nitride (GaN) has emerged as an excellent material for the fabrication of power devices. Among the semiconductors for which power devices are already available in the market, GaN has the widest energy gap, the largest critical field, and the highest saturation velocity, thus representing an excellent material for the fabrication of high-speed/high-voltage components. The presence of spontaneous and piezoelectric polarization allows us to create a two-dimensional electron gas, with high mobility and large channel density, in the absence of any doping, thanks to the use of AlGaN/GaN heterostructures. This contributes to minimize resistive losses; at the same time, for GaN transistors, switching losses are very low, thanks to the small parasitic capacitances and switching charges. Device scaling and monolithic integration enable a high-frequency operation, with consequent advantages in terms of miniaturization. For high power/high-voltage operation, vertical device architectures are being proposed and investigated, and three-dimensional structures—fin-shaped, trench-structured, nanowire-based—are demonstrating great potential. Contrary to Si, GaN is a relatively young material: trapping and degradation processes must be understood and described in detail, with the aim of optimizing device stability and reliability. This Tutorial describes the physics, technology, and reliability of GaN-based power devices: in the first part of the article, starting from a discussion of the main properties of the material, the characteristics of lateral and vertical GaN transistors are discussed in detail to provide guidance in this complex and interesting field. The second part of the paper focuses on trapping and reliability aspects: the physical origin of traps in GaN and the main degradation mechanisms are discussed in detail. The wide set of referenced papers and the insight into the most relevant aspects gives the reader a comprehensive overview on the present and next-generation GaN electronics.
Published: 2021

26. Biological control of invasive stink bugs: review of global state and future prospects

Author: Gonzalo A. Avila, Guillaume Martel, Raul Alberto Laumann, Gabriele Rondoni, Cesar Rodriguez-Saona, Barbara I. P. Barratt, Michael Rostás, Fernanda Cingolani, Eric Conti, Kim A. Hoelmer, Stefano Colazza, René Sforza, Eric Wajnberg, Luciana Tavella, Salvatore Guarino, Lara Maistrello, Ezio Peri, Pio Federico Roversi, Conti E., Avila G., Barratt B., Cingolani F., Colazza S., Guarino S., Hoelmer K., Laumann R.A., Maistrello L., Martel G., Peri E., Rodriguez-Saona C., Rondoni G., Rostas M., Roversi P.F., Sforza R.F.H., Tavella L., Wajnberg E., Dept. of Pharmaceutical Sciences, University of Perugia, The New Zealand Institute for Plant & Food Research Limited [Auckland] (Plant & Food Research), Better Border Biosecurity (B3), Partenaires INRAE, Centro de Estudios Parasitologicos y de Vectores [La Plata] (CEPAVE), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad Nacional de la Plata [Argentine] (UNLP)-Comisión de Investigaciones Científicas [Buenos Aires] (CIC), Università degli studi di Palermo - University of Palermo, Istituto di Bioscienze e BioRisorse [Palermo] (IBBR), Consiglio Nazionale delle Ricerche (CNR), USDA-ARS : Agricultural Research Service, Embrapa Recursos Genéticos e Biotecnologia [Brasília], Università degli Studi di Modena e Reggio Emilia (UNIMORE), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), European Biological Control Laboratory (EBCL), United States Department of Agriculture (USDA), Rutgers University System (Rutgers), Georg-August-University [Göttingen], Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA), Università degli studi di Torino (UNITO), HExapode, PHysiologie, AssISTance et Objets de Service (HEPHAISTOS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Georg-August-University = Georg-August-Universität Göttingen, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), Università degli studi di Torino = University of Turin (UNITO), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)
Subjects: 0106 biological sciences, Integrated pest management, Biological pest control, Tachinidae, pre-emptive classical biological control, landscape management, 010603 evolutionary biology, 01 natural sciences, invasive species, Hemiptera, Encyrtidae, invasive specie, Pentatomidae, biocontrol, biocontrol chemical ecology Hemiptera invasive species landscape management pre‐emptive classical biological control semiochemicals parasitoid Pentatomidae risk assessment Tachinidae Scelionidae, parasitoid, Ecology, Evolution, Behavior and Systematics, Bagrada hilaris, biology, semiochemicals, business.industry, Ecology, Pest control, chemical ecology, preemptive classical biological control, risk assessment, semiochemical, biocontrol, chemical ecology, Hemiptera, invasive species, landscape management, preemptive classical biological control, semiochemicals, parasitoid, Pentatomidae, risk assessment, Tachinidae, Scelionidae, biology.organism_classification, 010602 entomology, Settore AGR/11 - Entomologia Generale E Applicata, 13. Climate action, Insect Science, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, business, Scelionidae, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract: International audience; Invasive stink bugs (Hemiptera: Pentatomidae) are responsible for high economic losses to agricul-ture on a global scale. The most important species, dating from recent to old invasions, includeBagrada hilaris (Burmeister), Halyomorpha halys (Stal), Piezodorus guildinii (Westwood), Nezara vir-idula (L.), and Murgantia histrionica (Hahn). Bagrada hilaris, H. halys,andN. viridula are nowalmost globally distributed. Biological control of these pests faces a complex set of challenges thatmust be addressed to maintain pest populations below the economic injury level. Several case studiesof classical and conservation biological control of invasive stink bugs are reported here. The mostcommon parasitoids in their geographical area of origin are egg parasitoids (Hymenoptera: Scelion-idae, Encyrtidae, and Eupelmidae). Additionally, native parasitoids of adult stink bugs (Diptera:Tachinidae) have in some cases adapted to the novel hosts in the invaded area and native predatorsare known to prey on the various instars. Improving the efﬁcacy of biocontrol agents is possiblethrough conservation biological control techniques and exploitation of their chemical ecology.Moreover, integration of biological control with other techniques, such as behavioural manipulationof adult stink bugs and plant resistance, may be a sustainable pest control method within organicfarming and integrated pest management programs. However, additional ﬁeld studies are needed toverify the efﬁcacy of these novel methods and transfer them from research to application.
Published: 2021

27. Chapitre 9. Diatomées, pollen et micro-fossiles non polliniques : apports de l’étude des microrestes à la compréhension des structures archéologiques

Author: Aude, Beauger, Florenzano, Assunta, Miras, Yannick, Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne (UCA)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), and Miras, Yannick
Subjects: [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SDE.ES] Environmental Sciences/Environmental and Society, [SHS] Humanities and Social Sciences, [SDE.ES]Environmental Sciences/Environmental and Society, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2021

28. Clinical validation of a computer‐based approach for the quantification of the skin ageing process of women using in vivo confocal microscopy

Author: K. Vié, Giovanni Pellacani, Michel Couprie, Benjamin Perret, Julie Robic, Alex Nkengne, Hugues Talbot, Laboratoire d'Informatique Gaspard-Monge (LIGM), École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, Laboratoires Clarins, ESIEE Paris, OPtimisation Imagerie et Santé (OPIS), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de vision numérique (CVN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-CentraleSupélec-Université Paris-Saclay, CentraleSupélec, Université Paris-Saclay, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), and Università degli Studi di Modena e Reggio Emilia (UNIMORE)
Subjects: Skin ageing, Intravital Microscopy, In vivo confocal microscopy, [INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS], Dermatology, Skin Aging, 030207 dermatology & venereal diseases, 03 medical and health sciences, Reflectance confocal microscopy, 0302 clinical medicine, 0502 economics and business, Medicine, Humans, Skin, Microscopy, Confocal, integumentary system, business.industry, Computers, 05 social sciences, Computer based, Infectious Diseases, Mathematical morphology, Scientific method, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], 050211 marketing, Female, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Graphical models, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], business, Biomedical engineering
Abstract: International audience; Reflectance confocal microscopy (RCM) is a powerful tool to visualize the skin layers at cellular resolution up to adepth of 200µm. A semi-quantitative score of skin aging from RCM images has been previously published, requiring visualassessment of the images by experienced dermatologists. In this article we propose new computer-basedmethods to automatically quantify the skin aging process on RCM image.
Published: 2021

29. Chapitre 10. Environnement du site et anthropisation du milieu

Author: Florenzano, Assunta, Hallavant, Charlotte, Miras, Yannick, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), and Miras, Yannick
Subjects: [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SDE.ES] Environmental Sciences/Environmental and Society, [SDE.ES]Environmental Sciences/Environmental and Society, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021

30. How our Dreams Changed During the COVID-19 Pandemic: Effects and Correlates of Dream Recall Frequency - a Multinational Study on 19,355 Adults

Author: Damien Leger, Brigitte Holzinger, Kentaro Matsui, Markku Partinen, Thomas Penzel, Ngan Yin Chan, Ilona Merikanto, Mariusz Siemiński, Giuseppe Plazzi, Serena Scarpelli, Colin A. Espie, Yves Dauvilliers, Sérgio A. Mota-Rolim, Charles M. Morin, Eirin Fränkl, Yun Kwok Wing, Yuichi Inoue, Frances Chung, Michael R. Nadorff, Tainá Macêdo, Luigi De Gennaro, Courtney J. Bolstad, Bjørn Bjorvatn, Medizinische Universität Wien = Medical University of Vienna, Department of Psychology [University of Roma 'La Sapienza'], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Mississippi State University [Mississippi], Baylor College of Medicine (BCM), Baylor University, Haukeland University Hospital, University of Bergen (UiB), The Chinese University of Hong Kong [Hong Kong], University of Toronto, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Nuffield Department of Clinical Neurosciences [Oxford], University of Oxford [Oxford], Tokyo Medical University, Japan Somnology Center, Sommeil-Vigilance-Fatigue et Santé Publique (VIFASOM (URP_7330)), Institut de Recherche Biomédicale des Armées (IRBA)-Université Paris Cité (UPC), Centre du Sommeil et de la Vigilance [Paris], Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Universidade Federal do Rio Grande do Norte [Natal] (UFRN), National Center of Neurology and Psychiatry National Institute of Mental Health (NCNP), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Finnish Institute for Health and Welfare [Helsinki, Finland] (FIHW), Orton Orthopaedic Hospital (Orton Ltd), Centre de recherche de l’Institut universitaire en santé mentale de Québec [Canada] (CERVO), Département de réadaptation (Faculté de médecine de l'Université Laval) [Canada], Faculté de médecine de l'Université Laval [Québec] (ULaval)-Faculté de médecine de l'Université Laval [Québec] (ULaval), Terveystalo Oy, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], IRCCS Istituto delle Scienze Neurologiche di Bologna [Bologna, Italy], Ospedale Bellaria [Bologna, Italy], Università degli Studi di Modena e Reggio Emilia (UNIMORE), Medical University of Gdańsk, Clinical and Behavioral Neurology - Neuroscienze e riabilitazione, IRCCS Fondazione Santa Lucia [Roma], Faculty of Psychology [Vienna], University of Vienna [Vienna], SLEEPWELL Research Program, Faculty of Medicine, Department of Neurosciences, Clinicum, and HUS Neurocenter
Subjects: Neurophysiology and neuropsychology, RC435-571, Logistic regression, REM sleep behavior disorder, 050105 experimental psychology, Collective threat, Mental health, Parasomnia, Sleep, Sleep disorder, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, McNemar's test, collective threat, Nature and Science of Sleep, medicine, 0501 psychology and cognitive sciences, sleep, sleep disorder, mental health, parasomnia, Applied Psychology, Depression (differential diagnoses), Original Research, Psychiatry, business.industry, QP351-495, 05 social sciences, 3112 Neurosciences, medicine.disease, 3. Good health, 3121 General medicine, internal medicine and other clinical medicine, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Anxiety, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, business, 030217 neurology & neurosurgery, Clinical psychology
Abstract: Objective Many have reported odd dreams during the pandemic. Given that dreams are associated with mental health, understanding these changes could provide crucial information about wellbeing during the pandemic. This study explored associations between COVID-19 and dream recall frequency (DRF), and related social, health, and mental health factors. Methods We conducted a cross-sectional web survey of 19,355 individuals in 14 countries from May to July 2020. We collected data on COVID-19, mental health, sleep and DRF during the pandemic. We performed McNemar Tests to compare low (, Video abstract Point your SmartPhone at the code above. If you have a QR code reader, the video abstract will appear. Or use: https://youtu.be/Qerns3HLO7o
Published: 2021

31. Engineering Chemisorption of Fe 4 Single‐Molecule Magnets on Gold

Author: Totti Federico, Ohresser Philippe, Poggini Lorenzo, Erik Tancini, Barra Anne-Laure, Sessoli Roberta, Chiara Danieli, Caneschi Andrea, Jean Paul Kappler, Cucinotta Giuseppe, Li Weibin, Mannini Matteo, Arrio Marie-Anne, Malavolti Luigi, Lunghi Alessandro, Joly Loïc, Serrano Giulia, Andrea Cornia, Juhin Amélie, Otero Edwige, Sainctavit Philippe, Andrea Sorrentino, Istituto di Chimica dei Composti Organometallici (ICCOM), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Università degli Studi di Firenze = University of Florence (UniFI), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Laboratoire national des champs magnétiques intenses - Grenoble (LNCMI-G ), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Consiglio Nazionale delle Ricerche (CNR), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and Gestionnaire, Hal Sorbonne Université
Subjects: Materials science, single-molecule magnets, self-assembled monolayers, nanomagnetism, synchrotron radiation, spintronics, ab initio molecular dynamics, DFT, Synchrotron radiation, 02 engineering and technology, ab initio molecular dynamics, DFT, nanomagnetism, self-assembled monolayers, single-molecule magnets, spintronics, synchrotron radiation, 010402 general chemistry, 01 natural sciences, Ab initio molecular dynamics, Condensed Matter::Materials Science, Molecule, [CHIM.MATE] Chemical Sciences/Material chemistry, Spintronics, Mechanical Engineering, Self-assembled monolayer, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, equipment and supplies, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry, Mechanics of Materials, Chemical physics, Chemisorption, Magnet, 0210 nano-technology, human activities
Abstract: International audience; Gaining control over the grafting geometry is critically important for any application of surface-supported single-molecule magnets (SMMs) in data storage, spintronics, and quantum information science. Here, tetrairon(III) SMMs with a propeller-like structure are functionalized with thioacetyl-terminated alkyl chains to promote chemisorption on gold surfaces from solution and to evaluate differences in adsorption geometry and magnetic properties as a function of chain length. The prepared monolayers are investigated using X-ray absorption techniques with linearly and circularly polarized light to extract geometrical and magnetic information, respectively. All derivatives remain intact and form partially oriented monolayers on the gold surface. A ligand-field analysis of the observed X-ray natural linear dichroism shows that the threefold molecular axis is invariably biased toward the surface normal, in agreement with ab initio calculations. This preferential orientation is most pronounced in monolayers of the shortest-chain derivative, which are further studied with an ultralow temperature X-ray magnetic circular dichroism setup operating down to 350 mK. The isothermal field sweeps with the magnetic field at normal incidence show an open hysteresis loop below 1 K, while measurements at different incidence angles prove the magnetic anisotropy of the monolayers.
Published: 2021

32. Dopaminergic Treatment Effects on Dysarthric Speech: Acoustic Analysis in a Cohort of Patients With Advanced Parkinson's Disease

Author: Francesco Cavallieri, Carla Budriesi, Annalisa Gessani, Sara Contardi, Valentina Fioravanti, Elisa Menozzi, Serge Pinto, Elena Moro, Franco Valzania, Francesca Antonelli, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), and Pinto, Serge
Subjects: medicine.medical_specialty, Levodopa, Parkinson's disease, speech, Audiology, lcsh:RC346-429, 03 medical and health sciences, Dysarthria, 0302 clinical medicine, dysarthria, Rating scale, medicine, otorhinolaryngologic diseases, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Phonation, levodopa, 030223 otorhinolaryngology, lcsh:Neurology. Diseases of the nervous system, Original Research, business.industry, Dopaminergic, medicine.disease, acoustic analysis, Neurology, Dyskinesia, dyskinesias, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Cohort, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: Importance: The effects of dopaminergic treatment on speech in patients with Parkinson's disease (PD) are often mixed and unclear. The aim of this study was to better elucidate those discrepancies.Methods: Full retrospective data from advanced PD patients before and after an acute levodopa challenge were collected. Acoustic analysis of spontaneous monologue and sustained phonation including several quantitative parameters [i.e., maximum phonation time (MPT); shimmer local dB] as well as the Unified Parkinson's Disease Rating Scale (UPDRS) (total scores, subscores, and items) and the Clinical Dyskinesia Rating Scale (CDRS) were performed in both the defined-OFF and -ON conditions. The primary outcome was the changes of speech parameters after levodopa intake. Secondary outcomes included the analysis of possible correlations of motor features and levodopa-induced dyskinesia (LID) with acoustic speech parameters. Statistical analysis included paired t-test between the ON and OFF data (calculated separately for male and female subgroups) and Pearson correlation between speech and motor data.Results: In 50 PD patients (male: 32; female: 18), levodopa significantly increased the MPT of sustained phonation in female patients (p < 0.01). In the OFF-state, the UPDRS part-III speech item negatively correlated with MPT (p = 0.02), whereas in the ON-state, it correlated positively with the shimmer local dB (p = 0.01), an expression of poorer voice quality. The total CDRS score and axial subscores strongly correlated with the ON-state shimmer local dB (p = 0.01 and p < 0.01, respectively).Conclusions: Our findings emphasize that levodopa has a poor effect on speech acoustic parameters. The intensity and location of LID negatively influenced speech quality.
Published: 2021

33. Cognitive benefits of exercise interventions: an fMRI activation likelihood estimation meta-analysis

Author: Arthur F. Kramer, Ben Klugah-Brown, Liye Zou, Benjamin Becker, Stéphane Perrey, Nicola Veronese, Qian Yu, Fabian Herold, Notger G. Müller, Yanjie Zhang, Laboratoire de Physique et d'Etude des Matériaux (UMR 8213) (LPEM), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Shenzhen University, German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), University of Electronic Science and Technology of China (UESTC), EuroMov - Digital Health in Motion (Euromov DHM), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Montpellier (UM), Università degli studi di Palermo - University of Palermo, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Yu, Q., Herold, F., Becker, B., Klugah-Brown, B., Zhang, Y., Perrey, S., Veronese, N., Müller, N.G., Kramer, A.F., and Zou, L.
Subjects: medicine.medical_specialty, Histology, Neurology, [SDV]Life Sciences [q-bio], Precuneus, Network, Physical exercise, Subgroup analysis, Exercise · Cognition · Brain health · Network, 050105 experimental psychology, [SCCO]Cognitive science, 03 medical and health sciences, physiology [Brain], methods [Magnetic Resonance Imaging], 0302 clinical medicine, Physical medicine and rehabilitation, Cognition, Neuroimaging, physiopathology [Nerve Net], medicine, Humans, 0501 psychology and cognitive sciences, ddc:610, Exercise, ComputingMilieux_MISCELLANEOUS, Default mode network, Likelihood Functions, business.industry, General Neuroscience, 05 social sciences, physiology [Cognition], Brain, Magnetic Resonance Imaging, [STAT]Statistics [stat], medicine.anatomical_structure, Meta-analysis, Brain health, physiology [Nerve Net], sense organs, Anatomy, Nerve Net, business, 030217 neurology & neurosurgery
Abstract: Despite a growing number of functional MRI studies reporting exercise-induced changes during cognitive processing, a systematic determination of the underlying neurobiological pathways is currently lacking. To this end, our neuroimaging meta-analysis included 20 studies and investigated the influence of physical exercise on cognition-related functional brain activation. The overall meta-analysis encompassing all experiments revealed physical exercise-induced changes in the left parietal lobe during cognitive processing. Subgroup analysis further revealed that in the younger-age group (< 35years old) physical exercise induced more widespread changes in the right hemisphere, whereas in the older-age group (≥ 35years old) exercise-induced changes were restricted to the left parietal lobe. Subgroup analysis for intervention duration showed that shorter exercise interventions induced changes in regions connected with frontoparietal and default mode networks, whereas regions exhibiting effects of longer interventions connected with frontoparietal and dorsal attention networks. Our findings suggest that physical exercise interventions lead to changes in functional activation patterns primarily located in precuneus and associated with frontoparietal, dorsal attention and default mode networks. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Published: 2020

34. Grape stalk: a first attempt to disentangle its fibres via electrostatic separation

Author: Francesca Masino, Andrea Antonelli, Claire Mayer-Laigle, Xavier Rouau, Giuseppe Montevecchi, Umberto Cancelli, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Emilia-Romagna Region, Italy, [grant number CUP E81I18003220009 Bando Alte Competenze, 'Recovery of useful molecules from low-value waste of the wine industry' (Ref. PA: 2016-8349/RER), PO FSE 2014-2020 'Safety, Quality and Integration of regional agri-food chains to increase their competitiveness'].
Subjects: 0106 biological sciences, General Chemical Engineering, Lignocellulosic biomass, biopolymers, biopolymers triboelectric effect dry biorefinery lignocellulosic biomass sugar source building blocks, Fractionation, Furfural, 7. Clean energy, 01 natural sciences, Biochemistry, building blocks, chemistry.chemical_compound, 0404 agricultural biotechnology, 010608 biotechnology, [SDV.IDA]Life Sciences [q-bio]/Food engineering, dry biorefinery, triboelectric effect, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, lignocellulosic biomass, Aqueous solution, Chromatography, food and beverages, Fructose, 04 agricultural and veterinary sciences, Biorefinery, 040401 food science, Electrostatic separation, chemistry, sugar source, Acid hydrolysis, Food Science, Biotechnology
Abstract: International audience; The aim of the study was to assess the effectiveness of the electrostatic separation on fractionation and deconstruction of the grape stalks lignocellulosic biomass. After the measurements of their physical properties, the eight fractions obtained were extracted with hot water and then with hot 2% sulphuric acid.In aqueous extracts, the concentrations of glucose and fructose of samples collected in the jars under the positive electrode were as high as 13.5 and 11.6 g/100 g d.w., respectively. As for acid hydrolysis, the concentration of furfural and HMF were 1996–2600 and 144–291 mg/kg d.w., respectively.The results showed the opportunity of using grape stalks as a source of fermentable sugars, as well as a potential source of furanic compounds. This technique can represent a new and affordable method of lignocellulosic biomass pre-treatment which can easily be integrated into a biorefinery to favour partial fractionation and better exposure of the fractions to a subsequent enzymatic or chemical attack.
Published: 2020

35. Plea for multitargeted interventions for severe COVID-19

Author: Cristina Mussini, Sharon Walmsley, Georg M. N. Behrens, Benjamin Gaborit, Jean-François Bergmann, Anton Pozniak, François Raffi, Jose R. Arribas, Department of Infectious Diseases [Nantes], Hôtel-Dieu de Nantes, Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Internal Medicine Department [Paris], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Hospital Universitario La Paz [Madrid, Espagne], Hannover Medical School [Hannover] (MHH), Toronto General Hospital Research Institute [Canada] (TGHRI), Chelsea and Westminster Hospital, London School of Hygiene and Tropical Medicine (LSHTM), Bodescot, Myriam, and Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE)
Subjects: 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Pneumonia, Viral, Psychological intervention, Antiviral Agents, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Plea, Pandemic, medicine, Humans, Immunologic Factors, Intensive care medicine, Pandemics, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, 0303 health sciences, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, biology, SARS-CoV-2, business.industry, COVID-19, medicine.disease, biology.organism_classification, COVID-19 Drug Treatment, Pneumonia, Infectious Diseases, 030220 oncology & carcinogenesis, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Drug Therapy, Combination, Immunotherapy, Coronavirus Infections, business, Immunosuppressive Agents
Abstract: International audience
Published: 2020
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36. An in-situ x-ray diffraction and infrared spectroscopic study of the dehydration of AlPO4-54

Author: Bernard Fraisse, Marco Fabbiani, Rossella Arletti, Michelangelo Polisi, Mario Santoro, Frederico G. Alabarse, Julien Haines, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Dipartimento di chimica (IFM) (Dipartimento di chimica (IFM)), Università degli studi di Torino (UNITO), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Istituto Nazionale di Ottica (INO), and Consiglio Nazionale delle Ricerche (CNR)
Subjects: Materials science, Analytical chemistry, Infrared spectroscopy, 02 engineering and technology, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, 01 natural sciences, Crystal, Phase (matter), General Materials Science, infrared spectroscopy, Dehydration, Aluminophosphate, X-ray diffraction, dehydration, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, x-ray diffraction, X-ray crystallography, Anhydrous, Crystallite, 0210 nano-technology, Single crystal, Monoclinic crystal system
Abstract: International audience; The dehydration of the large pore aluminophosphate AlPO4-54•xH2O was studied in situ as a function of vacuum pressure at room temperature by infrared spectroscopy and x-ray diffraction. On polycrystalline samples, under primary vacuum, the adsorbed water is removed very rapidly. The structural water in the AlO6 octahedra is then removed slowly with the quantity of the fully dehydrated form gradually increasing from 43 to 65% of the total material. This results in a two-phase mixture of fully dehydrated and a distinct partially dehydrated AlPO4-54•1/2H2O phase containing structural water. These phases have almost identical a cell parameters and very close c parameters. Secondary vacuum increases the amount of fully dehydrated material to more than 76%. Prolonged heating under vacuum increases the amount of fully dehydrated material to 90%. On single crystal samples, removal of adsorbed water is slower and results in a reduction in crystal quality, however prolonged exposure to primary vacuum yielded fully dehydrated material without the need for heating. The monoclinic structure of anhydrous AlPO4-54, space group Cm, with a doubled unit cell was confirmed using single crystal synchrotron x-ray diffraction data.
Published: 2020

37. Observational Hertzsprung-Russell diagrams

Author: Eyer, L., Rimoldini, L., Audard, M., Anderson, R. I., Nienartowicz, K., Glass, F., Marchal, O., Grenon, M., Mowlavi, N., Holl, B., Clementini, G., Aerts, C., Mazeh, T., Evans, D. W., Szabados, L., Brown, A. G. A., Vallenari, A., Prusti, T., de Bruijne, J. H. J., Babusiaux, C., Bailer-Jones, C. A. L., Biermann, M., Jansen, F., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Luri, X., Mignard, F., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Siddiqui, H. I., Soubiran, C., van Leeuwen, F., Walton, N. A., Arenou, F., Bastian, U., Cropper, M., Drimmel, R., Katz, D., Lattanzi, M. G., Bakker, J., Cacciari, C., Castañeda, J., Chaoul, L., Cheek, N., De Angeli, F., Fabricius, C., Guerra, R., Masana, E., Messineo, R., Panuzzo, P., Portell, J., Riello, M., Seabroke, G. M., Tanga, P., Thévenin, F., Gracia-Abril, G., Comoretto, G., Garcia-Reinaldos, M., Teyssier, D., Altmann, M., Andrae, R., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Burgess, P., Busso, G., Carry, B., Cellino, A., Clotet, M., Creevey, O., Davidson, M., De Ridder, J., Delchambre, L., Dell’Oro, A., Ducourant, C., Fernández-Hernández, J., Fouesneau, M., Frémat, Y., Galluccio, L., García-Torres, M., González-Núñez, J., González-Vidal, J. J., Gosset, E., Guy, L. P., Halbwachs, J.-L., Hambly, N. C., Harrison, D. L., Hernández, J., Hestroffer, D., Hodgkin, S. T., Hutton, A., Jasniewicz, G., Jean-Antoine-Piccolo, A., Jordan, S., Korn, A. J., Krone-Martins, A., Lanzafame, A. C., Lebzelter, T., Löffler, W., Manteiga, M., Marrese, P. M., Martín-Fleitas, J. M., Moitinho, A., Mora, A., Muinonen, K., Osinde, J., Pancino, E., Pauwels, T., Petit, J.-M., Recio-Blanco, A., Richards, P. J., Robin, A. C., Sarro, L. M., Siopis, C., Smith, M., Sozzetti, A., Süveges, M., Torra, J., van Reeven, W., Abbas, U., Abreu Aramburu, A., Accart, S., Altavilla, G., Álvarez, M. A., Alvarez, R., Alves, J., Andrei, A. H., Anglada Varela, E., Antiche, E., Antoja, T., Arcay, B., Astraatmadja, T. L., Bach, N., Baker, S. G., Balaguer-Núñez, L., Balm, P., Barache, C., Barata, C., Barbato, D., Barblan, F., Barklem, P. S., Barrado, D., Barros, M., Barstow, M. A., Bartholomé Muñoz, S., Bassilana, J.-L., Becciani, U., Bellazzini, M., Berihuete, A., Bertone, S., Bianchi, L., Bienaymé, O., Blanco-Cuaresma, S., Boch, T., Boeche, C., Bombrun, A., Borrachero, R., Bossini, D., Bouquillon, S., Bourda, G., Bragaglia, A., Bramante, L., Breddels, M. A., Bressan, A., Brouillet, N., Brüsemeister, T., Brugaletta, E., Bucciarelli, B., Burlacu, A., Busonero, D., Butkevich, A. G., Buzzi, R., Caffau, E., Cancelliere, R., Cannizzaro, G., Cantat-Gaudin, T., Carballo, R., Carlucci, T., Carrasco, J. M., Casamiquela, L., Castellani, M., Castro-Ginard, A., Charlot, P., Chemin, L., Chiavassa, A., Cocozza, G., Costigan, G., Cowell, S., Crifo, F., Crosta, M., Crowley, C., Cuypers, J., Dafonte, C., Damerdji, Y., Dapergolas, A., David, P., David, M., de Laverny, P., De Luise, F., De March, R., de Martino, D., de Souza, R., de Torres, A., Debosscher, J., del Pozo, E., Delbo, M., Delgado, A., Delgado, H. E., Diakite, S., Diener, C., Distefano, E., Dolding, C., Drazinos, P., Durán, J., Edvardsson, B., Enke, H., Eriksson, K., Esquej, P., Eynard Bontemps, G., Fabre, C., Fabrizio, M., Faigler, S., Falcão, A. J., Farràs Casas, M., Federici, L., Fedorets, G., Fernique, P., Figueras, F., Filippi, F., Findeisen, K., Fonti, A., Fraile, E., Fraser, M., Frézouls, B., Gai, M., Galleti, S., Garabato, D., García-Sedano, F., Garofalo, A., Garralda, N., Gavel, A., Gavras, P., Gerssen, J., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomes, M., Granvik, M., Gueguen, A., Guerrier, A., Guiraud, J., Gutiérrez-Sánchez, R., Haigron, R., Hatzidimitriou, D., Hauser, M., Haywood, M., Heiter, U., Helmi, A., Heu, J., Hilger, T., Hobbs, D., Hofmann, W., Holland, G., Huckle, H. E., Hypki, A., Icardi, V., Janßen, K., Jevardat de Fombelle, G., Jonker, P. G., Juhász, Á. L., Julbe, F., Karampelas, A., Kewley, A., Klar, J., Kochoska, A., Kohley, R., Kolenberg, K., Kontizas, M., Kontizas, E., Koposov, S. E., Kordopatis, G., Kostrzewa-Rutkowska, Z., Koubsky, P., Lambert, S., Lanza, A. F., Lasne, Y., Lavigne, J.-B., Le Fustec, Y., Le Poncin-Lafitte, C., Lebreton, Y., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Lenhardt, H., Leroux, F., Liao, S., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., López, M., Lorenz, D., Managau, S., Mann, R. G., Mantelet, G., Marchant, J. M., Marconi, M., Marinoni, S., Marschalkó, G., Marshall, D. J., Martino, M., Marton, G., Mary, N., Massari, D., Matijevič, G., McMillan, P. J., Messina, S., Michalik, D., Millar, N. R., Molina, D., Molinaro, R., Molnár, L., Montegriffo, P., Mor, R., Morbidelli, R., Morel, T., Morgenthaler, S., Morris, D., Mulone, A. F., Muraveva, T., Musella, I., Nelemans, G., Nicastro, L., Noval, L., O’Mullane, W., Ordénovic, C., Ordóñez-Blanco, D., Osborne, P., Pagani, C., Pagano, I., Pailler, F., Palacin, H., Palaversa, L., Panahi, A., Pawlak, M., Piersimoni, A. M., Pineau, F.-X., Plachy, E., Plum, G., Poggio, E., Poujoulet, E., Prša, A., Pulone, L., Racero, E., Ragaini, S., Rambaux, N., Ramos-Lerate, M., Regibo, S., Reylé, C., Riclet, F., Ripepi, V., Riva, A., Rivard, A., Rixon, G., Roegiers, T., Roelens, M., Romero-Gómez, M., Rowell, N., Royer, F., Ruiz-Dern, L., Sadowski, G., Sagristà Sellés, T., Sahlmann, J., Salgado, J., Salguero, E., Sanna, N., Santana-Ros, T., Sarasso, M., Savietto, H., Schultheis, M., Sciacca, E., Segol, M., Segovia, J. C., Ségransan, D., Shih, I.-C., Siltala, L., Silva, A. F., Smart, R. L., Smith, K. W., Solano, E., Solitro, F., Sordo, R., Soria Nieto, S., Souchay, J., Spagna, A., Spoto, F., Stampa, U., Steele, I. A., Steidelmüller, H., Stephenson, C. A., Stoev, H., Suess, F. F., Surdej, J., Szegedi-Elek, E., Tapiador, D., Taris, F., Tauran, G., Taylor, M. B., Teixeira, R., Terrett, D., Teyssandier, P., Thuillot, W., Titarenko, A., Torra Clotet, F., Turon, C., Ulla, A., Utrilla, E., Uzzi, S., Vaillant, M., Valentini, G., Valette, V., van Elteren, A., Van Hemelryck, E., van Leeuwen, M., Vaschetto, M., Vecchiato, A., Veljanoski, J., Viala, Y., Vicente, D., Vogt, S., von Essen, C., Voss, H., Votruba, V., Voutsinas, S., Walmsley, G., Weiler, M., Wertz, O., Wevers, T., Wyrzykowski, Ł., Yoldas, A., Žerjal, M., Ziaeepour, H., Zorec, J., Zschocke, S., Zucker, S., Zurbach, C., Zwitter, T., Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Systèmes de Référence Temps Espace (SYRTE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Geneva Observatory, University of Geneva [Switzerland], ISDC Data Centre for Astrophysics, Probabilités, statistique, physique mathématique (PSPM), Institut Camille Jordan [Villeurbanne] (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'astrophysique de l'observatoire de Besançon (LAOB), Institut national des sciences de l'Univers (INSU - 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University of Greifswald, Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), Lund Observatory, Lund University [Lund], Departament d'Astronomia i Meteorologia [Barcelona] (DAM), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Université Libre de Bruxelles [Bruxelles] (ULB), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Royal Greenwich Observatory (RGO), Zentrum für astronomie, Universität Heidelberg [Heidelberg], Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), International Center for Relativistic Astrophysics (ICRA), Università degli Studi di Roma, Department of Intensive Care, Erasmus Medical Centre, Department of Biomedical Sciences, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Laboratorio de Inmunologıa y Virologıa, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolas de los Garza, University of Barcelona, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - 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Osservatorio Astrofisico di Catania (OACT), European Space Astronomy Centre (ESAC), SIM/IDL Faculdade de Ciências da Universidade de Lisboa (FCUL), University of Lisboa, Universidad de Granada (UGR), Department of Physics [Helsinki], Falculty of Science [Helsinki], University of Helsinki-University of Helsinki, Osservatorio Astronomico di Bologna (OABO), Universidad Nacional de Educación a Distancia (UNED), AUTRES, Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), National Institute for Subatomic Physics Nikhef [Amsterdam] (NIKHEF), PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), IDAEA-CSIC, Department of Physics and Astronomy [Uppsala], Departamento de Astrofisica [Madrid], Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Department of Physics and Astronomy [Leicester], University of Leicester, University of Cadiz, CEA Le Ripault (CEA Le Ripault), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Observatoire astronomique de Strasbourg (OAS), Institut national des sciences de l'Univers (INSU - 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Ciencia Molecular, Universitat de València (UV), Astronomical Observatory [Poznan], Adam Mickiewicz University in Poznań (UAM), Université Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Panthéon-Sorbonne (UP1), Department of Computer Science, Università degli Studi di Verona, Thales Services, THALES, Departement d'Astrophysique Stellaire et Galactique (DASGAL), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL), Center for health studies, Dipartimento di Fisica, Politecnico di Milano [Milan] (POLIMI), Astrometry, Istituto Nazionale di Astrofisica (INAF)-Istituto Nazionale di Astrofisica (INAF), Karl-Franzens-Universität Graz, Institute of Hydrology, Argelander Institute for Astronomy (AlfA), Rheinische Friedrich-Wilhelms-Universität Bonn, Astronomical Observatory of the University of Warsaw, University of Warsaw (UW), Institut d'Astrophysique de Paris (IAP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Lohrmann Observatory, University of Ljubljana, Department of nuclear medicine, Haukeland University Hospital, University of Bergen (UIB)-University of Bergen (UIB), Human Cancer Genetics Program, Comprehensive Cancer Center-College of Medicine and Public Health [Colombus], Departament de Geodinamica i Geofısica, Facultat de Geologia, M2A 2012, Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Solvay Silica, Solvay (France), Instituto Dom Luiz, Universidade de Lisboa (ULISBOA), Department of Medicine, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Department of Environmental Chemistry, IDAEA-CSIC, Spanish National Research Council (CSIC), FORMATION STELLAIRE 2012, CICEnergigune, INAF - Osservatorio Astronomico di Roma (OAR), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' [Rome], Aberystwyth University, Department of Food & Nutritional Sciences, University of Reading (UOR), Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Sigma CLERMONT (Sigma CLERMONT)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche de l'European Business School (IREBS), European Business School Paris (EBS Paris), LEI, Wageningen University and Research Centre [Wageningen] (WUR), National University of Ireland [Galway] (NUI Galway), Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences [Budapest], Laboratoire de Cosmologie, Astrophysique Stellaire & Solaire, de Planétologie et de Mécanique des Fluides (CASSIOPEE), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Centre National d'Etudes Spatiales (CNES), M2A 2015, Department of Biomedical, Metabolic and Neural Sciences [Modena], Università degli Studi di Modena e Reggio Emilia [Reggio Emilia] (UNIMORE), Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], Université de Las Palmas de Gran Canaria [Espagne] (ULPGC), Astrophysique Interprétation Modélisation (AIM - UMR 7158 - UMR E 9005), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Université Côte d'Azur (UCA), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Chaim Sheba Medical Center [Ramat Gan, Israel], University of Catania, Groupement de Recherche et d'Etudes en Gestion à HEC (GREGH), Ecole des Hautes Etudes Commerciales (HEC Paris)-Centre National de la Recherche Scientifique (CNRS), Helsinki Observatory, University of Helsinki [Helsinki], Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), R&D Tonnellerie Radoux, Tonnellerie Radoux, Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), M2A 2013, Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics [Philadelphia], University of Pennsylvania [Philadelphia], M2A 2014, Groupe de Recherche en Astronomie et Astrophysique du Languedoc (GRAAL), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Haute-Provence (OHP), Institut Pythéas (OSU PYTHEAS), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département d'Astrophysique (ex SAP) (DAP), Universidad de Alicante, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Lille, Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Physics Department, University of Crete (UOC), DEE, Budapest University of Technology and Economics [Budapest] (BME), European Space Astronomy Centre, KELLER Fondations spéciales, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ingienerie des Polymères pour les Hautes Technologies (LIPHT), Ecole européenne de chimie, polymères et matériaux [Strasbourg]-Centre National de la Recherche Scientifique (CNRS), Helsinki University of Techology, Centre for Integrative Physiology, University of Edinburgh, Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département de Neurologie [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-IFR70-CHU Pitié-Salpêtrière [APHP], Fondation Universitaire Notre Dame de la Paix (FUNDP), Facultés Universitaires Notre-Dame de la Paix, Institut Mines-Télécom [Paris]-Institut Mines-Télécom [Paris]-Centre G2I, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Etudes Spatiales (CNES), Laboratoire Hubert Curien [Saint Etienne] (LHC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Instituto de Plasmas e Fusão Nuclear [Lisboa] (IPFN), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), EURATOM CIEMAT (CIEMAT), Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Geophysical Laboratory [Carnegie Institution], Carnegie Institution for Science [Washington], Politecnico di Milano [Milan], Equipe EES, Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), University of Freiburg [Freiburg], Ben-Gurion University of the Negev (BGU), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU]Sciences of the Universe [physics], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

38. β-arrestin 2 Is a Prognostic Factor for Survival of Ovarian Cancer Patients Upregulating Cell Proliferation

Author: Czogalla, Bastian, Partenheimer, Alexandra, Jeschke, Udo, Schönfeldt, Viktoria von, Mayr, Doris, Mahner, Sven, Burges, Alexander, Simoni, Manuela, Melli, Beatrice, Benevelli, Riccardo, Bertini, Sara, Casarini, Livio, Trillsch, Fabian, Ludwig Maximilian University [Munich] (LMU), University Hospital Augsburg, Department of Biomedical, Metabolic and Neural Sciences [Modena], Università degli Studi di Modena e Reggio Emilia, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Azienda Ospedaleria Universitaria di Modena, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Adult, Ovarian Neoplasms, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Cell Survival, Kaplan-Meier Estimate, Middle Aged, Prognosis, beta-Arrestin 2, survival analysis, in vitro analyses, G protein-coupled receptor, immunohistochemistry, ovarian cancer, β-arrestin 2, Endocrinology, HEK293 Cells, Receptors, Gonadotropin, Biomarkers, Tumor, Humans, Female, ddc:610, Original Research, Cell Proliferation
Abstract: International audience; Establishing reliable prognostic factors as well as specific targets for new therapeutic approaches is an urgent requirement in advanced ovarian cancer. For several tumor entities, the ubiquitously spread scaffold protein beta-arrestin 2, a multifunctional scaffold protein regulating signal transduction and internalization of activated G protein-coupled receptors (GPCRs), has been considered with rising interest for carcinogenesis. Therefore, we aimed to elucidate the prognostic impact of beta-arrestin 2 and its functional role in ovarian cancer. beta-arrestin 2 expression was analyzed in a subset of 156 samples of ovarian cancer patients by immunohistochemistry. Cytoplasmic expression levels were correlated with clinical as well as pathological characteristics and with prognosis. The biologic impact of beta-arrestin 2 on cell proliferation and survival was evaluated,in vitro. Following transient transfection by increasing concentrations of plasmid encoding beta-arrestin 2, different cell lines were evaluated in cell viability and death. beta-arrestin 2 was detected in all histological ovarian cancer subtypes with highest intensity in clear cell histology. High beta-arrestin 2 expression levels correlated with high-grade serous histology and the expression of the gonadotropin receptors FSHR and LHCGR, as well as the membrane estrogen receptor GPER and hCG beta. Higher cytoplasmic beta-arrestin 2 expression was associated with a significantly impaired prognosis (median 29.88 vs. 50.64 months;P= 0.025). Clinical data were confirmed in transfected HEK293 cells, human immortalized granulosa cell line (hGL5) and the ovarian cancer cell line A2780in vitro, where the induction of beta-arrestin 2 cDNA expression enhanced cell viability, while the depletion of the molecule by siRNA resulted in cell death. Reflecting the role of beta-arrestin 2 in modulating GPCR-induced proliferative and anti-apoptotic signals, we propose beta-arrestin 2 as an important prognostic factor and also as a promising target for new therapeutic approaches in advanced ovarian cancer.
Published: 2020

39. The HPC-DAG Task Model for Heterogeneous Real-Time Systems

Author: Zahaf, Houssam-Eddine, Houssam-Eddine, Zahaf, Capodieci, Nicola, Cavicchioli, Roberto, Lipari, Giuseppe, Bertogna, Marko, Laboratoire des Sciences du Numérique de Nantes (LS2N), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de Technologie - Nantes (IUT Nantes), Université de Nantes (UN), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Lille, Sciences et Technologies, Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE)
Subjects: Computer science, Heuristic, Distributed computing, media_common.quotation_subject, Degree of parallelism, 02 engineering and technology, heterogeneous architectures, Real-time systems, scheduling, Directed acyclic graph, 020202 computer hardware & architecture, Theoretical Computer Science, Task (project management), Scheduling (computing), Computational Theory and Mathematics, Hardware and Architecture, Component-based software engineering, 0202 electrical engineering, electronic engineering, information engineering, Task analysis, [INFO]Computer Science [cs], Function (engineering), Software, ComputingMilieux_MISCELLANEOUS, media_common
Abstract: Recent commercial hardware platforms for embedded real-time systems feature heterogeneous processing units and computing accelerators on the same System-on-Chip. When designing complex real-time applications for such architectures, the designer is exposed to a number of difficult choices, like deciding on which compute engine to execute a certain task, or what degree of parallelism to adopt for a given function. To help the designer exploring the wide space of design choices and tune the scheduling parameters, we propose a novel real-time application model, called HPC-DAG ( Heterogeneous Parallel Condition Directed Acyclic Graph Model ), specifically conceived for heterogeneous platforms. An HPC-DAG allows the system designer to specify alternative implementations of a software component for different processing engines, as well as conditional branches to model if-then-else statements. We also propose a schedulability analysis for the HPC-DAG model and a set of heuristic allocation algorithms aimed at improving schedulability for latency sensitive applications. Our analysis takes into account the cost of preempting a task, which can be non-negligible on certain processors. We show the use of our approach on a realistic case study, and we demonstrate its effectiveness by comparing it with state-of-the-art algorithms previously proposed in literature.
Published: 2020

40. Time-Fluid Field-Based Coordination

Author: Pianini, Danilo, Mariani, Stefano, Viroli, Mirko, Zambonelli, Franco, University of Bologna, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Simon Bliudze, Laura Bocchi, TC 6, WG 6.1, Pianini D., Mariani S., Viroli M., and Zambonelli F.
Subjects: IoT, Computer science, Distributed computing, Internet of Things, 0211 other engineering and technologies, 0102 computer and information sciences, 02 engineering and technology, 01 natural sciences, Aggregate computing, Causality, Edge computing, Fluidware, Reactive, Time, Article, Fluid field, Scheduling (computing), [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], Openness to experience, [INFO]Computer Science [cs], 021103 operations research, Spacetime, business.industry, 010201 computation theory & mathematics, Software deployment, Internet of Thing, business, Global time
Abstract: Part 6: Large-Scale Decentralised Systems; International audience; Emerging application scenarios, such as cyber-physical systems (CPSs), the Internet of Things (IoT), and edge computing, call for coordination approaches addressing openness, self-adaptation, heterogeneity, and deployment agnosticism. Field-based coordination is one such approach, promoting the idea of programming system coordination declaratively from a global perspective, in terms of functional manipulation and evolution in “space and time” of distributed data structures, called fields. More specifically, regarding time, in field-based coordination it is assumed that local activities in each device, called computational rounds, are regulated by a fixed clock, typically, a fair and unsynchronized distributed scheduler. In this work, we challenge this assumption, and propose an alternative approach where the round execution scheduling is naturally programmed along with the usual coordination specification, namely, in terms of a field of causal relations dictating what is the notion of causality (why and when a round has to be locally scheduled) and how it should change across time and space. This abstraction over the traditional view on global time allows us to express what we call “time-fluid” coordination, where causality can be finely tuned to select the event triggers to react to, up to to achieve improved balance between performance (system reactivity) and cost (usage of computational resources). We propose an implementation in the aggregate computing framework, and evaluate via simulation on a case study.
Published: 2020

41. CO2 adsorption in nanosized RHO zeolites with different chemical compositions and crystallite sizes

Author: Nicolas Barrier, Julien Grand, Rossella Arletti, Giorgia Confalonieri, Svetlana Mintova, Laboratoire catalyse et spectrochimie (LCS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 2 - Sciences et Techniques (UM2)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Laboratoire de physique des océans (LPO), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Department of Chemical and Geological Siences, University of Modena and Reggio-Emilia, Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), and Università degli Studi di Modena e Reggio Emilia (UNIMORE)
Subjects: In situ, Materials science, In situ XRD, In situ IR spectroscopy, Analytical chemistry, Infrared spectroscopy, 02 engineering and technology, Na-Cs RHO, 010402 general chemistry, 01 natural sciences, Adsorption, [CHIM]Chemical Sciences, General Materials Science, in situ XRD, Zeolite, ComputingMilieux_MISCELLANEOUS, X-ray, CO, 2, adsorption, Nanosized, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, nanosized, 0104 chemical sciences, Mechanics of Materials, in situ IR spectroscopy, Crystallite, 0210 nano-technology, CO2 adsorption, Powder diffraction, Bar (unit)
Abstract: International audience; In this work, nanosized RHO zeolite samples with different Si/Al ratios were synthetized and tested for CO2 adsorption by combining in situ IR spectroscopy and in situ X-ray powder diffraction using synchrotron radiation. The structural changes of the RHO nanosized zeolites subjected to high temperature treatment (350 ºC) and CO2 adsorption (1 and 5 Bars) studied by high-resolution X ray powder diffraction indicated the presence of two phases with different cell parameters in both samples. The combination of the X-ray technique with IR allowed evaluation of the CO2 adsorption capacity of the samples and their adsorption dynamic. The results indicated that the CO2 adsorption capacity is mainly related to the sodium content in the nanosized RHO crystals. The adsorption experiments performed showed that 1 bar CO2 is sufficient to saturate the RHO samples at room temperature, and no change in the CO2 adsorption capacity at 5 bars was observed.
Published: 2020

42. FSH for the Treatment of Male Infertility

Author: Livio Casarini, Clara Lazzaretti, Elia Paradiso, Pascale Crépieux, Giulia Brigante, Vincenzo Rochira, Daniele Santi, Manuela Simoni, Eric Reiter, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Dynamiques de populations multi-échelles pour des systèmes physiologiques (MUSCA), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Biomedical, Metabolic and Neural Sciences [Modena], Università degli Studi di Modena e Reggio Emilia, Azienda Ospedaleria Universitaria di Modena, European Project: 665790,H2020,H2020-MSCA-COFUND-2014,SMART LOIRE VALLEY(2015), University of Modena and Reggio Emilia, Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Inria Saclay - Ile de France, Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), International PhD School in Clinical and Experimental Medicine (CEM), Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE)
Subjects: 0301 basic medicine, Male, [SDV]Life Sciences [q-bio], Gonadotropin-releasing hormone, Review, male infertility, Male infertility, lcsh:Chemistry, 0302 clinical medicine, FSH, Medicine, lcsh:QH301-705.5, Spectroscopy, media_common, fertility, 030219 obstetrics & reproductive medicine, General Medicine, Sertoli cell, Computer Science Applications, medicine.anatomical_structure, Gonadotropin, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, medicine.medical_specialty, endocrine system, medicine.drug_class, media_common.quotation_subject, FSH, gonadotropins, male infertility, spermatogenesis, testis, biosimilars, fertility, therapy, Fertility, testis, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Hypogonadotropic hypogonadism, Internal medicine, Animals, Humans, biosimilars, Physical and Theoretical Chemistry, gonadotropin, Molecular Biology, Infertility, Male, therapy, business.industry, Hypogonadism, Organic Chemistry, medicine.disease, spermatogenesis, 030104 developmental biology, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, Follicle Stimulating Hormone, business, Spermatogenesis, Hormone, gonadotropins
Abstract: International audience; Follicle-stimulating hormone (FSH) supports spermatogenesis acting via its receptor (FSHR), which activates trophic effects in gonadal Sertoli cells. These pathways are targeted by hormonal drugs used for clinical treatment of infertile men, mainly belonging to sub-groups defined as hypogonadotropic hypogonadism or idiopathic infertility. While, in the first case, fertility may be efficiently restored by specific treatments, such as pulsatile gonadotropin releasing hormone (GnRH) or choriogonadotropin (hCG) alone or in combination with FSH, less is known about the efficacy of FSH in supporting the treatment of male idiopathic infertility. This review focuses on the role of FSH in the clinical approach to male reproduction, addressing the state-of-the-art from the little data available and discussing the pharmacological evidence. New compounds, such as allosteric ligands, dually active, chimeric gonadotropins and immunoglobulins, may represent interesting avenues for future personalized, pharmacological approaches to male infertility
Published: 2020

43. Toward a plasma-based accelerator at high beam energy with high beam charge and high beam quality

Author: Gilles Maynard, Xiaojian Li, L. A. Gizzi, Anna Giribono, Massimo Ferrario, P. Lee, Ralph Assmann, F. Massimo, Bernhard Hidding, Andrea Rossi, Jiebei Zhu, Paolo Tomassini, A. Martinez de la Ossa, E. N. Svystun, Jorge Vieira, A. Beck, A. Chancé, Brigitte Cros, Cristina Vaccarezza, A. Ferran Pousa, T. Silva, Phu Anh Phi Nghiem, S. Romeo, Alberto Marocchino, Enrica Chiadroni, A. Mosnier, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratori Nazionali di Frascati (LNF), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire de physique des gaz et des plasmas (LPGP), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze Fisiche, Informatiche e Matematiche [Modena], Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Guizhou Institute of Technology, Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Centro de Fisica de Plasmas (GoLP), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), State Key Lab of Estuarine and Coastal Research, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Università degli Studi di Modena e Reggio Emilia (UNIMORE)
Subjects: Physics and Astronomy (miscellaneous), Computer science, wake field [plasma], plasma: wake field, beam transport, 01 natural sciences, 7. Clean energy, law.invention, wake field [accelerator], particle: acceleration, accelerator: wake field, law, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], high [charge], beam: injection, QC, Surfaces and Interfaces, Particle acceleration, quality, plasma-based facility, plasma wakefield acceleration, high brightness beams, Laser beam quality, injection [beam], Nuclear and High Energy Physics, Plasma parameters, Acceleration, charge: high, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, ddc:530, Aerospace engineering, 010306 general physics, numerical calculations, 010308 nuclear & particles physics, business.industry, bibliography, Plasma, Plasma acceleration, Laser, sensitivity, beam loading, laser, lcsh:QC770-798, beam profile, business, Beam (structure), acceleration [particle]
Abstract: Physical review accelerators and beams 23(3), 031301 (2020). doi:10.1103/PhysRevAccelBeams.23.031301, From plasma-wakefield acceleration as a physics experiment toward a plasma-based accelerator as a user facility, the beam physics issues remaining to be solved are still numerous. Providing beams with high energy, charge, and quality simultaneously, not only within the plasma but also at the user doorstep itself, is the main concern. Despite its tremendous efficiency in particle acceleration, the wakefield displays a complex 3D profile which, associated to the beam-loading field induced by the accelerated beam itself, makes the acceleration of high charge to high energy often incompatible with high beam quality. Beam extraction from the plasma without quality degradation for a transfer either to the next plasma stage or to the user application is another difficulty to consider. This article presents the substantial studies carried out and the different innovative methods employed for tackling all these different issues. Efforts focused on achieving the challenging beam parameters targeted by the EuPRAXIA accelerator facility project. The lessons learned at the end of these in-depth simulations and optimizations are highlighted. The sensitivity to different error sources is also estimated to point out the critical components of such an accelerator. Finally, the needs in terms of laser and plasma parameters are provided., Published by American Physical Society, College Park, MD
Published: 2020

44. A branch-and-price algorithm for the temporal bin packing problem

Author: Fabio Furini, Manuel Iori, Mauro Dell'Amico, Dipartimento di Scienze e Metodi dell'Ingegneria [Reggio Emilia] (DISMI), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Laboratoire d'analyse et modélisation de systèmes pour l'aide à la décision (LAMSADE), Université Paris Dauphine-PSL, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Bin packing problem, 0209 industrial biotechnology, 021103 operations research, General Computer Science, Computer science, Branch-and-price algorithm, Temporal bin packing problem, 0211 other engineering and technologies, 02 engineering and technology, Extension (predicate logic), Management Science and Operations Research, Bin, 020901 industrial engineering & automation, Optimization and Control (math.OC), Modeling and Simulation, FOS: Mathematics, Branch and price algorithm, [INFO]Computer Science [cs], Mathematics - Optimization and Control, Algorithm
Abstract: We study an extension of the classical Bin Packing Problem, where each item consumes the bin capacity during a given time window that depends on the item itself. The problem asks for finding the minimum number of bins to pack all the items while respecting the bin capacity at any time instant. A polynomial-size formulation, an exponential-size formulation, and a number of lower and upper bounds are studied. A branch-and-price algorithm for solving the exponential-size formulation is introduced. An overall algorithm combining the different methods is then proposed and tested through extensive computational experiments. (C) 2019 Elsevier Ltd. All rights reserved.
Published: 2020

45. A comprehensive theoretical picture of E centers in silicon: from optical properties to vacancy-mediated dopant diffusion

Author: Anne Hémeryck, Nicolas Richard, G Herrero-Saboya, Layla Martin-Samos, Antoine Jay, Équipe Modélisation Multi-niveaux des Matériaux (LAAS-M3), Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Dipartimento di Fisica, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Istituto Officina dei Materiali (CNR-IOM), National Research Council [Italy] (CNR), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, and Università degli Studi di Modena e Reggio Emilia (UNIMORE)
Subjects: 010302 applied physics, GW approximation, [PHYS]Physics [physics], Materials science, Condensed matter physics, Silicon, Dopant, General Physics and Astronomy, chemistry.chemical_element, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Crystallographic defect, chemistry, Vacancy defect, 0103 physical sciences, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Density functional theory, Diffusion (business), 0210 nano-technology, Absorption (electromagnetic radiation)
Abstract: Among the common vacancy-related point defects in silicon, the E center is one of the most prominent due to its degrading effect in silicon-based technology. Even though it has been the subject of extensive experimental and theoretical studies, a comprehensive theoretical model capable of reproducing the experimental evidence for all three dopants (P, As, and Sb) is still missing. Guided by a Jahn-Teller model, we are able to reproduce the absorption bands and the transition probability between equivalent geometries of the defect at low temperatures by including many-body-perturbation corrections based on the GW approximation on top of the density functional theory. At higher temperatures, vacancies become mobile centers, enabling the reorientation of the whole defect and contributing to the dopant diffusion. The underlying mechanisms of the vacancy-mediated dopant diffusion are revisited, characterizing the activation energies of such technologically relevant processes and obtaining quantitative results in good agreement with experiment.
Published: 2020

46. FSH treatment of male idiopathic infertility: Time for a paradigm change

Author: Daniele Santi, Manuela Simoni, Università degli Studi di Modena e Reggio Emilia (UNIMORE), LE STUDIUM Loire Valley Institute for Advanced Studies, and This project has been supported by LE STUDIUM Loire Valley Institute for Advanced Studies, Orléans & Tours, France with funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665790
Subjects: Male, endocrine system, Urology, Endocrinology, Diabetes and Metabolism, Bioinformatics, Male infertility, law.invention, 03 medical and health sciences, Follicle-stimulating hormone, 0302 clinical medicine, Endocrinology, Randomized controlled trial, Hypogonadotropic hypogonadism, law, Follicular phase, medicine, Humans, Infertility, Male, 030219 obstetrics & reproductive medicine, business.industry, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, medicine.disease, 3. Good health, Clinical trial, Reproductive Medicine, Follicle Stimulating Hormone, business, Spermatogenesis, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Hormone
Abstract: International audience; Follicle‐stimulating hormone (FSH) has been used in inconclusive clinical trials for male idiopathic infertility in the past. FSH is sometimes prescribed empirically for male idiopathic infertility, showing some improvement in sperm parameters in about half of the patients. In this opinion article, we briefly analyze the pathophysiological evidences in favor of a more aggressive approach in planning future studies on pharmacological FSH use in male infertility, in analogy with the FSH use for multiple follicular growth in women undergoing ovarian stimulation for assisted reproduction. There is sufficient evidence that spermatogenesis does not run at its top in the primate and that some extra FSH can stimulate spermatogenesis over its baseline. Existing data suggest that the pharmacological regimens applied so far were insufficient, both in dosage and in duration, to elicit this response in about half of the patients. A paradigm change is needed now: We should move away from the classical, endocrinological approach, which simply applied the substitutive, therapeutic regimen used in hypogonadotropic hypogonadism, toward testing a ‘testicular hyperstimulation’ scheme for a time sufficient to cover more than only one spermatogenic cycle, a concept to be verified in an appropriately controlled, prospective, randomized clinical trial.
Published: 2020

47. Cretaceous Evolution of the Central Asian Proto‐Paratethys Sea: Tectonic, Eustatic, and Climatic Controls

Author: Zhaojie Guo, Mehmut Mamtimin, Marius Stoica, Pierrick Roperch, Jean-Noël Proust, Jovid Aminov, Guillaume Dupont-Nivet, Chiara Fioroni, Niels Meijer, Joost Frieling, Mustafa Kaya, Sevinç Özkan Altıner, Institut für Geowissenschaften [Potsdam], Universität Potsdam, Géosciences Rennes (GR), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Escuela Superior Politécnica del Litoral (ESPOL), Utrecht University [Utrecht], Università degli Studi di Modena e Reggio Emilia (UNIMORE), Middle East Technical University [Ankara] (METU), University of Bucharest (UniBuc), Institute of Geology, Earthquake Engineering and Seismology, Academy of Sciences of the Republic of Tajikistan, MAGIC 649081, European Research Council, University of Potsdam = Universität Potsdam, Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE)
Subjects: [SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics, Tectonic subsidence, 010504 meteorology & atmospheric sciences, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], Subsidence, Biostratigraphy, Structural basin, 010502 geochemistry & geophysics, 01 natural sciences, Cretaceous, Paleontology, Geophysics, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Geochemistry and Petrology, [SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/Stratigraphy, Period (geology), 14. Life underwater, Cenomanian, Magnetostratigraphy, Geology, 0105 earth and related environmental sciences
Abstract: International audience; The timing and mechanisms of the Cretaceous sea incursions into Central Asia are still poorly constrained. We provide a new chronostratigraphic framework based on biostratigraphy and magnetostratigraphy together with detailed paleoenvironmental analyses of Cretaceous records of the proto-Paratethys Sea fluctuations in the Tajik and Tarim basins. The Early Cretaceous marine incursion in the western Tajik Basin was followed by major marine incursions during the Cenomanian (ca. 100 Ma) and Santonian (ca. 86 Ma) that reached far into the eastern Tajik and Tarim basins. These marine incursions were separated by a Turonian-Coniacian (ca. 92-86 Ma) regression. Basin-wide tectonic subsidence analyses imply that the Early Cretaceous sea incursion into the Tajik Basin was related to increased Pamir tectonism. We find that thrusting along the northern edge of the Pamir at ca. 130-90 Ma resulted in increased subsidence in a retro-arc basin setting. This tectonic event and coeval eustatic highstand resulted in the maximum observed geographic extent of the sea during the Cenomanian (ca. 100 Ma). The following Turonian-Coniacian (ca. 92-86 Ma) major regression, driven by eustasy, coincides with a sharp slowdown in tectonic subsidence during the late orogenic unloading period with limited thrusting. The Santonian (ca. 86 Ma) major sea incursion was likely controlled by eustasy as evidenced by the coeval fluctuations in the west Siberian Basin. An early Maastrichtian cooling (ca. 71-70 Ma), potentially connected to global Late Cretaceous trends, is inferred from the replacement of mollusk-rich limestones by bryozoan-and echinoderm-rich limestones.
Published: 2020
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48. Deep Unfolding of a Proximal Interior Point Method for Image Restoration

Author: Marco Prato, Emilie Chouzenoux, Jean-Christophe Pesquet, Marie-Caroline Corbineau, Carla Bertocchi, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Centre de vision numérique (CVN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay, OPtimisation Imagerie et Santé (OPIS), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de vision numérique (CVN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-CentraleSupélec-Université Paris-Saclay, and Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE)
Subjects: FOS: Computer and information sciences, Deblurring, Computer Science - Machine Learning, neural network, Stability (learning theory), proximal algorithms, 02 engineering and technology, image restoration, Theoretical Computer Science, Machine Learning (cs.LG), [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], 0202 electrical engineering, electronic engineering, information engineering, FOS: Mathematics, Interior point method, deep unfolding, Mathematics - Optimization and Control, Mathematical Physics, Image restoration, Mathematics, Artificial neural network, business.industry, Interior point method, proximal algorithms, deep unfolding, neural network, image restoration, regularization, Applied Mathematics, Deep learning, 020206 networking & telecommunications, Backpropagation, Computer Science Applications, regularization, Optimization and Control (math.OC), [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Signal Processing, 020201 artificial intelligence & image processing, Artificial intelligence, Interior point methods, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Gradient descent, business, Algorithm, Neural networks
Abstract: International audience; Variational methods are widely applied to ill-posed inverse problems for they have the ability to embed prior knowledge about the solution. However, the level of performance of these methods significantly depends on a set of parameters, which can be estimated through computationally expensive and time-consuming methods. In contrast, deep learning offers very generic and efficient architectures, at the expense of explainability, since it is often used as a black-box, without any fine control over its output. Deep unfolding provides a convenient approach to combine variational-based and deep learning approaches. Starting from a variational formulation for image restoration, we develop iRestNet, a neural network architecture obtained by unfolding a proximal interior point algorithm. Hard constraints, encoding desirable properties for the restored image, are incorporated into the network thanks to a logarithmic barrier, while the barrier parameter, the stepsize, and the penalization weight are learned by the network. We derive explicit expressions for the gradient of the proximity operator for various choices of constraints, which allows training iRestNet with gradient descent and backpropagation. In addition, we provide theoretical results regarding the stability of the network for a common inverse problem example. Numerical experiments on image deblurring problems show that the proposed approach compares favorably with both state-of-the-art variational and machine learning methods in terms of image quality.
Published: 2020

49. DisProt: intrinsic protein disorder annotation in 2020

Author: Hatos, András, Hajdu-Soltész, Borbála, Monzon, Alexander M., Palopoli, Nicolas, Álvarez, Lucía, Aykac-Fas, Burcu, Bassot, Claudio, Benítez, Guillermo I., Bevilacqua, Martina, Chasapi, Anastasia, Chemes, Lucia, Davey, Norman E., Davidović, Radoslav, Dunker, A. Keith, Elofsson, Arne, Gobeill, Julien, Foutel, Nicolás S. González, Sudha, Govindarajan, Guharoy, Mainak, Horvath, Tamas, Iglesias, Valentin, Kajava, Andrey V., Kovacs, Orsolya P., Lamb, John, Lambrughi, Matteo, Lazar, Tamas, Leclercq, Jeremy Y., Leonardi, Emanuela, Macedo-Ribeiro, Sandra, Macossay-Castillo, Mauricio, Maiani, Emiliano, Manso, José A., Marino-Buslje, Cristina, Martínez-Pérez, Elizabeth, Mészáros, Bálint, Mičetić, Ivan, Minervini, Giovanni, Murvai, Nikoletta, Necci, Marco, Ouzounis, Christos A., Pajkos, Mátyás, Paladin, Lisanna, Pancsa, Rita, Papaleo, Elena, Parisi, Gustavo, Pasche, Emilie, Barbosa Pereira, Pedro J., Promponas, Vasilis J., Pujols, Jordi, Quaglia, Federica, Ruch, Patrick, Salvatore, Marco, Schad, Eva, Szabo, Beata, Szaniszló, Tamás, Tamana, Stella, Tantos, Agnes, Veljkovic, Nevena, Ventura, Salvador, Vranken, Wim, Dosztányi, Zsuzsanna, Tompa, Peter, Tosatto, Silvio C. E., Piovesan, Damiano, Promponas, Vasilis J. [0000-0003-3352-4831], Universita degli Studi di Padova, Vinča Institute of Nuclear Sciences, University of Belgrade [Belgrade], Stockholm University, Laboratoire Leibniz (Leibniz - IMAG), Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF), Laboratoire de biochimie théorique [Paris] (LBT (UPR_9080)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut de biologie physico-chimique (IBPC (FR_550)), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Reproductive Neuroscience Unit, Department of Obstetrics and Gynecology and Department of Neurobiology, Yale University School of Medicine, Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia (UNIMORE), Structural Biology Brussels (SBB), Vrije Universiteit Brussel (VUB), Instituto de Biologia Molecular e Celular (IBMC), Hungarian Academy of Sciences (MTA), Institute of Agrobiotechnology, National Center for Research and Technology, Universidad Nacional de Quilmes (UNQ), Université de Genève et Hôpitaux Universitaires de Genève (SIM), Hôpitaux Universitaires de Genève (HUG), Biophysics and Bioinformatics Laboratory, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona (UAB), Service d'informatique médicale (SIM), Hôpitaux de Genève, Department of Structural Biology, Biophysics Research Group [Budapest] (ELTE-MTA 'Lendület'), Department of Bio-engineering Sciences, Structural Biology Brussels, Faculty of Sciences and Bioengineering Sciences, Informatics and Applied Informatics, Chemistry, Basic (bio-) Medical Sciences, Instituto de Investigação e Inovação em Saúde, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Institut de biologie physico-chimique (IBPC), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Vrije Universiteit [Brussels] (VUB), Universitat Autònoma de Barcelona [Barcelona] (UAB), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut de biologie physico-chimique (IBPC (FR_550)), and Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Disordered proteins, Interface (Java), Disorder Ontology, [SDV]Life Sciences [q-bio], Interoperability, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Ontology (information science), Biology, 03 medical and health sciences, Annotation, Genetics, Database Issue, Databases, Protein, ComputingMilieux_MISCELLANEOUS, Data Curation, 030304 developmental biology, Graphical user interface, Structure (mathematical logic), 0303 health sciences, Intrinsically Disordered Proteins / chemistry, Information retrieval, Intrinsically disordered proteins, Data curation, Molecular sequence annotation, business.industry, 030302 biochemistry & molecular biology, Intrinsic protein, Biological Ontologies, Molecular Sequence Annotation, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Intrinsically Disordered Proteins, Dark proteome, Ontology, Intrisic protein disorder, Literature curation, business, Biological ontologies
Abstract: The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website. The website includes a redesigned graphical interface, a better search engine, a clearer API for programmatic access and a new annotation interface that integrates text mining technologies. The new entry format provides a greater flexibility, simplifies maintenance and allows the capture of more information from the literature. The new disorder ontology has been formalized and made interoperable by adopting the OWL format, as well as its structure and term definitions have been improved. The new annotation interface has made the curation process faster and more effective. We recently showed that new DisProt annotations can be effectively used to train and validate disorder predictors. We believe the growth of DisProt will accelerate, contributing to the improvement of function and disorder predictors and therefore to illuminate the 'dark' proteome. Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) of Argentina [PICT-2015/3367, PICT-2017/1924]; Ministry of Education, Science and Technological Development of the Republic of Serbia [ON173001]; Vetenskapsrådet [2016-03798]; Hungarian National Research, Development, and Innovation Office (NKFIH) [FK-128133]; Italian Ministry of Health Young Investigator Grant [GR-2011-02347754]; Ministerio de Economía y Competitividad (MINECO) [BIO2016-78310-R]; ICREA (ICREA-Academia 2015); Fundac¸ão para a Ciência e a Tecnologia (FCT, Portugal); European Regional Development Fund [POCI-01-0145-FEDER-031173, POCI-01-0145-FEDER-029221]; Mexican National Council of Science and Technology (CONACYT) [215503]; Elixir-GR, Action ‘Reinforcement of the Research and Innovation Infrastructure’, Operational Programme ‘Competitiveness, Entrepreneurship and Innovation’ [NSRF 2014-2020]. co-financed by Greece and the European Union (European Regional Development Fund); Hungarian Academy of Sciences [PREMIUM-2017-48]; Carlsberg Distinguished Fellowship [CF18-0314]; Danmarks Grundforskningsfond [DNRF125]; National Research, Development and Innovation Office [K-125340]; Research Foundation Flanders (FWO) [G.0328.16N]; Hungarian Academy of Sciences [LP2014-18]; OTKA [K108798 and K124670]. This project has received funding from the European Union’s Horizon 2020 research and innovation programme [778247]. Funding for open access charge: European Union’s Horizon 2020 research and innovation programme [778247]. Conflict of interest statement. None declared.
Published: 2020

50. Equidispersive Dual-Mode Long Slot Arrays

Author: Mauro Ettorre, Michele Del Mastro, Ronan Sauleau, Stefano Lenzini, Del Mastro M., Lenzini S., Sauleau R., Ettorre M., Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia (UNIMORE), and Nantes Université (NU)-Université de Rennes 1 (UR1)
Subjects: Physics, parallel-plate waveguide, Circular polarization (CP), Axial ratio, Mathematical analysis, 020206 networking & telecommunications, equidispersive (ED), 02 engineering and technology, Cutoff frequency, law.invention, Transverse plane, [SPI]Engineering Sciences [physics], law, Surface wave, continuous transverse stub (CTS) array, impedance boundary condition (IBC), ortho-mode, Dispersion (optics), 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering, Waveguide, Electrical impedance, Circular polarization
Abstract: International audience; In this letter, we propose an analytic study for engineering equidispersive (ED) orthomode parallel-plate waveguide (PPW) structures. As difference with classical PPWs having perfectly conducting walls, the metallic plates are here replaced by arbitrary surface impedance boundaries. Closed-form expressions are provided to engineer their dispersion and obtain purely ED dual-mode propagation exploiting transverse electric and magnetic modes. This new class of PPWs is finally used as radiating open-ended stubs, arranged in a periodic environment to attain circular polarization. The corresponding axial ratio is calculated to be below 3 dB over a 22.3% fractional bandwidth.
Published: 2020

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