2,857 results on '"University of Frankfurt"'
Search Results
2. Validating Reward-related Biomarkers (RTOC) (RTOC)
- Author
-
P1vital Products LTD., Biotrial, University Hospital Frankfurt, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, The Institute of Neuropsychiatry and Addictions (INAD), Parc de Salut Mar, Barcelona, Aristotle University Of Thessaloniki, and Maastricht University, School for Mental Health and Neuroscience
- Published
- 2022
3. Postoperative i.v. Iron Substitution in Patients With Diagnosed Iron Deficiency (IDA-II)
- Author
-
University Hospital Frankfurt, Department of Anaesthesiology, IRON4U, University Hospital Frankfurt Institute for Biostatistics & Mathematical Modelling, and Dr. Frank Behrens, Sponsor representative
- Published
- 2021
4. Preliminary Efficacy and Safety of Apremilast in the Treatment of Acne Conglobata (APACCO)
- Author
-
Dermatology Department University Hospital Frankfurt, Celgene, and Dr. Frank Behrens, Sponsor representative
- Published
- 2022
5. EASINESS-TRIAL - Enhancing Safety in Epilepsy Surgery
- Author
-
Charite University, Berlin, Germany, University of Erlangen-Nürnberg, University Clinic Frankfurt, Vienna General Hospital, and Richard Drexler, Resident
- Published
- 2021
6. Management of Adrenal Emergency in Germany (MAdEy)
- Author
-
University Hospital, Frankfurt, Germany and Endocrinology in Charlottenburg, Berlin, Germany
- Published
- 2018
7. Adherence in Chronic Adrenal Insufficiency
- Author
-
Medical University of Graz, Austria, Medical practice for Endocrinology in Oldenburg, Germany, Charite University, Berlin, Germany, University Hospital, Frankfurt, Germany, Endocrinology in Charlottenburg, Berlin, Germany, University Hospital Munich, Germany, and University Hospital of Rostock, Germany
- Published
- 2018
8. Accessories in Kaiserstuhl carbonatites and related rocks as accurate and faithful recorders of whole rock age and isotopic composition
- Author
-
Ghobadi, Mahdi, Brey, Gerhard P., Gerdes, Axel, Höfer, Heidi E., Keller, Jörg, Institut Für Geowissenschaften, J.-W. Goethe Universität, Frankfurt, Germany, Frankfurt Isotope and Element Research Center (FIERCE), Goethe University Frankfurt, Frankfurt, Germany, and Mineralogisch-Petrographisches Institut, Universität, Freiburg, Germany
- Subjects
In situ determination of U–Pb ages ,In situ determination of Sr, Nd and Hf isotope ratios ,ddc:551.9 ,Accessories in carbonatites ,General Earth and Planetary Sciences ,Kaiserstuhl - Abstract
The accessories perovskite, pyrochlore, zirconolite, calzirtite and melanite from carbonatites and carbonate-rich foidites from the Kaiserstuhl are variously suited for the in situ determination of their U–Pb ages and Sr, Nd- and Hf-isotope ratios by LA-ICP-MS. The 143Nd/144Nd ratios may be determined precisely in all five phases, the 176Hf/177Hf ratios only in calzirtite and the 87Sr/86Sr ratios in perovskites and pyrochlores. The carbonatites and carbonate-rich foidites belong to one of the three magmatic groups that Schleicher et al. (1990) distinguished in the Kaiserstuhl on the basis of their Sr, Nd and Pb isotope ratios. Tephrites, phonolites and essexites (nepheline monzogabbros) form the second and limburgites (nepheline basanites) and olivine nephelinites the third. Our 87Sr/86Sr isotope data from the accessories overlap with the carbonatite and olivine nephelinite fields defined by Schleicher et al. (1990) but exhibit a much narrower range. These and the εNd and εHf values plot along the mantle array in the field of oceanic island basalts relatively close to mid-ocean ridge basalts. Previously reported K–Ar, Ar–Ar and fission track ages for the Kaiserstuhl lie between 16.2 and 17.8 Ma. They stem entirely from the geologically older tephrites, phonolites and essexites. No ages existed so far for the geologically younger carbonatites and carbonate-rich foidites except for one apatite fission track age (15.8 Ma). We obtained precise U–Pb ages for zirconolites and calzirtites of 15.66, respectively 15.5 Ma (± 0.1 2σ) and for pyrochlores of 15.35 ± 0.24 Ma. Only the perovskites from the Badberg soevite yielded a U–P concordia age of 14.56 ± 0.86 Ma while the perovskites from bergalites (haüyne melilitites) only gave 206Pb/238U and 208Pb/232Th ages of 15.26 ± 0.21, respectively, 15.28 ± 0.48 Ma. The main Kaiserstuhl rock types were emplaced over a time span of 1.6 Ma almost 1 million years before the carbonatites and carbonate-rich foidites. These were emplaced within only 0.32 Ma., Frankfurt Institute for Advanced Studies (FIAS) (4401)
- Published
- 2021
- Full Text
- View/download PDF
9. Fingerprinting kinetic isotope effects and diagenetic exchange reactions using fluid inclusion and dual-clumped isotope analysis
- Author
-
Staudigel, P., Davies, A. J., Bernecker, M., Tagliavento, M., van der Lubbe, H. J. L., Nooitgedacht, C., Looser, N., Bernasconi, S. M., Vonhof, H., Fiebig, J., 1 Institute of Geosciences Goethe University Frankfurt Frankfurt am Main Germany, 2 Department of Earth Sciences Vrije Universiteit Amsterdam Amsterdam The Netherlands, 3 Geological Institute ETH‐Zurich Zurich Switzerland, 4 Max Planck‐Institut für Chemie Mainz Germany, and Geology and Geochemistry
- Subjects
Geophysics ,fluid inclusions ,numerical modeling ,Geochemistry and Petrology ,ddc:551.9 ,clumped isotopes ,SDG 10 - Reduced Inequalities ,Diagenesis ,Clumped isotopes ,Fluid inclusions ,Numerical modeling ,diagenesis - Abstract
Geochemical analyses of carbonate minerals yield multiple parameters which can be used to estimate the temperature and water composition at which they formed. Analysis of fluid trapped in minerals is a potentially powerful tool to reconstruct paleotemperatures as well as diagenetic and hydrothermal processes, as these could represent the parent fluid. Internal fluids play important roles during the alteration of carbonate fossils, lowering energetic barriers associated with resetting of clumped isotopes, as well as mediating the transport of elements during diagenesis. Here, we explore the behavior of the ∆47–∆48 “dual‐clumped” isotope thermometer during fluid‐carbonate interaction and demonstrate that it is highly sensitive to the water/carbonate ratio, behaving as a linear system in “rock buffered” alteration, and as a decoupled system in water‐dominated systems due to non‐linear mixing effects in ∆48. Dry heating experiments show that the extrapolated “heated” end‐member is indistinguishable from the predicted ∆47 and ∆48 value expected for the experimental temperature. Furthermore, we evaluate two common laboratory sampling methods for their ability to thermally alter samples. We find that the temperature of the commonly used crushing cells used to vapourize water for fluid inclusion δ18O analyses is insufficient to cause fluid‐carbonate oxygen isotope exchange, demonstrating its suitability for analyses of fluid inclusions in carbonates. We also find that belemnites sampled with a hand‐drill yield significantly warmer paleotemperatures than those sampled with mortar and pestle. We conclude that thermally‐driven internal fluid‐carbonate exchange occurs indistinguishably from isotopic equilibrium, limited by the extent to which internal water and carbonate can react., Plain Language Summary: Carbonate minerals contain multiple, independent, chemical and isotopic parameters which can be used to calculate the temperature at which the mineral formed. If these proxies agree with one another, it has been confidently assumed that the temperature is indeed genuine. Here, we investigate three such parameters and show how they record kinetic processes during mineral formation, as well as thermally‐driven processes which may alter a climate record. We find that this method could potentially be used to study the kinetic factors at play during biomineralization, even if the “true” temperature is unknown. We also find that some thermal processes result in all three parameters agreeing with one another. Because thermal alteration poses a potential dilemma for climate researchers, we investigate two common laboratory preparation techniques that involve heating a sample before analysis: drilling and heating sample for fluid inclusion analysis. We find that the heat of a drill is sufficient to facilitate these reactions, and potentially imparts a warm bias onto paleotemperatures, however the apparatus used for analyzing fluid inclusions does not appear to significantly alter the material. We conclude our approach using fluid inclusion analysis and dual‐clumped isotopes has the potential to resolve many ambiguities in interpreting climate records., Key Points: We explore the behavior of dual‐clumped and fluid‐inclusion isotope paleothermometers during thermal alteration. Different conditions during diagenesis may result in discrepant paleotemperature estimates, which may be used to identify altered records. Hand‐drilling belemnites produces sufficient heat to reset paleotemperatures, but the heat during analysis of fluid inclusions does not., DFG, https://doi.org/10.5281/zenodo.7565557
- Published
- 2023
- Full Text
- View/download PDF
10. Mantle Anisotropy in NW Namibia From XKS Splitting: Effects of Asthenospheric Flow, Lithospheric Structures, and Magmatic Underplating
- Author
-
Komeazi, Abolfazl, Kaviani, Ayoub, Rümpker, Georg, and 1 Institute of Geosciences Goethe‐University Frankfurt Frankfurt Germany
- Subjects
Geophysics ,lithospheric shearing ,Tristan da Cunha mantle plume ,General Earth and Planetary Sciences ,seismic anisotropy ,shear wave splitting ,Namibia ,continental breakup ,ddc:551.1 - Abstract
The presence of the Etendeka flood basalts in northwestern Namibia is taken as evidence for the activity of the Tristan da Cunha mantle plume during the continental breakup between Africa and South America. We investigate seismic anisotropy beneath NW Namibia by splitting analysis of core‐refracted teleseismic shear waves (XKS phases) to probe mantle flow and lithospheric deformation related to the tectonic history of the region. We present the results of the joint splitting analysis of XKS data collected from 34 onshore stations and 12 ocean‐bottom seismometers. The fast polarization directions (FPDs) are consistent with a model that combines the effects of lithospheric deformation and large‐scale mantle flow due to the NE motion of the African plate. The dominantly NNW‐SSE‐oriented FPDs in the northern part are likely caused by shallow lithospheric structures. Our observations do not show any strong evidence of a pervasive effect of the Tristan da Cunha mantle plume., Plain Language Summary: The geology of Northwest Namibia is characterized by the presence of flood basalts, originating from magma sourced in the Earth's mantle. The source magma of these flood basalts was produced during the passage of the African plate over a mantle plume, more than 80 million years ago, contemporaneous with the onset of the breakup of the South American plate from the African plate. The role of the mantle plume in the continental breakup can be examined by a seismological technique named shear wave splitting analysis. The mantle flow induces direction‐dependent physical properties, that is, seismic anisotropy, which causes a shear wave to split into two different components traveling at different speeds. The leading component is polarized in a direction representing the direction of the flow in the earth's mantle. Except for the northern part, the polarization direction of the fast shear wave is consistent with the model of mantle flow caused by the NE motion of the African plate and deformations in the lithosphere. The results of our study do not show any direct evidence for the direct impact of the mantle plume on the mantle beneath our region of study., Key Points: Upper mantle anisotropy beneath NW Namibia is a combined effect of the present‐day motion of the African Plate and lithospheric structures. No significant direct effect of the Tristan da Cunha mantle plume is observed in shear wave splitting measurements. Localized shearing in the lithosphere and crustal underplating are likely the main causes of the lateral variations in seismic anisotropy., https://doi.org/10.14470/KP6443475642, https://doi.org/10.14470/1N134371, https://doi.org/10.7914/SN/IU, https://doi.org/10.18715/SKS_SPLITTING_DATABASE, https://www.geophysik.uni-frankfurt.de/64002762/Software
- Published
- 2023
11. Mesocrystalline Architecture in Hyaline Foraminifer Shells Indicates a Non-Classical Crystallisation Pathway
- Author
-
Arns, A. I., Evans, D., Schiebel, R., Fink, L., Mezger, M., Alig, E., Linckens, J., Jochum, K. P., Schmidt, M. U., Jantschke, A., Haug, G. H., 2 Institute of Geosciences Goethe University Frankfurt Frankfurt Germany, 1 Max Planck Institute for Chemistry Mainz Germany, 3 Institute of Inorganic and Analytical Chemistry Goethe University Frankfurt Frankfurt Germany, 4 Faculty of Physics University of Vienna Vienna Austria, and 5 Institute of Geosciences Johannes Gutenberg University Mainz Mainz Germany
- Subjects
nonclassical crystallization ,biomineralization ,amorphous calcium carbonate ,precursor phases ,organic matrix ,nanoparticles ,ddc:561.9 ,Geophysics ,Geochemistry and Petrology ,ddc:549 - Abstract
Calcareous foraminifer shells (tests) represent one of the most important archives for paleoenvironmental and paleoclimatic reconstruction. To develop a mechanistic understanding of the relationship between environmental parameters and proxy signals, knowledge of the fundamental processes operating during foraminiferal biomineralization is essential. Here, we apply microscopic and diffraction‐based methods to address the crystallographic and hierarchical structure of the test wall of different hyaline foraminifer species. Our results show that the tests are constructed from micrometer‐scale oriented mesocrystals built of nanometer‐scale entities. Based on these observations, we propose a mechanistic extension to the biomineralization model for hyaline foraminifers, centered on the formation and assembly of units of metastable carbonate phases to the final mesocrystal via a non‐classical particle attachment process, possibly facilitated by organic matter. This implies the presence of metastable precursors such as vaterite or amorphous calcium carbonate, along with phase transitions to calcite, which is relevant for the mechanistic understanding of proxy incorporation in the hyaline foraminifers., Plain Language Summary: Foraminifers are single celled marine organisms typically half a millimeter in size, which form shells made of calcium carbonate. During their life, the chemical composition of their shells records environmental conditions. By analyzing fossil shells, past conditions can be reconstructed to understand ancient oceans and climate change. To do that correctly, we need to know exactly how foraminifers form their shell. We find that foraminifers build micrometer‐sized mesocrystals which are made of smaller building blocks. This means that the smallest building blocks form first and assemble to form a larger grain, which is oriented in a specific direction. To align all the building blocks, it is possible that they are first unstable and undergo transformation on assembly, during which their composition may change. By understanding and quantifying this process, the composition of the final fossil shell may be understood, ultimately leading to more reliable reconstructions of past environmental change., Key Points: Hyaline foraminiferal shells are built of micrometer sized mesocrystalline units. Biomineralization likely includes the formation and assembly of nanoparticles. Nanometer sized units suggest non‐classical crystal growth., https://doi.org/10.17617/3.D7HN3I
- Published
- 2022
- Full Text
- View/download PDF
12. Clay mineral formation in Permian rocks of a geothermal borehole at Northern Upper Rhine Graben, Germany
- Author
-
Nguyen-Thanh, Lan, Mählmann, Rafael Ferreiro, Hoang-Minh, Thao, Petschick, Rainer, Reischmann, Thomas, Nesbor, Heinz-Dieter, Ruttmann, Myriam, Fritsche, Johann-Gerhard, Technische Universität Darmstadt, Darmstadt, Germany, University of Science, Vietnam National University, Hanoi, Hanoi, Vietnam, Goethe University Frankfurt, Frankfurt am Main, Germany, and Hessian Agency for Nature Conservation, Environment and Geology, Wiesbaden, Germany
- Subjects
Upper Rhine Graben ,Geochemistry ,020101 civil engineering ,02 engineering and technology ,engineering.material ,010502 geochemistry & geophysics ,01 natural sciences ,ddc:549 ,0201 civil engineering ,Clay mineral ,Quartz ,Thermal gradient ,0105 earth and related environmental sciences ,Muscovite ,Epidote ,Authigenic ,Donnersberg Formation ,Diagenesis ,Smectite illitization ,Illite ,Magma ,engineering ,General Earth and Planetary Sciences ,Clay minerals ,Geothermal borehole ,Geology - Abstract
Hydrothermally altered rhyolite rocks in the Permian Donnersberg Formation of a geothermal borehole in the Northern Upper Rhine Graben (Germany) were investigated to find out answers for the low hydraulic conductivity of the rocks. The composition of clay minerals and the temperature of smectite–illite transformation were carried out using X-ray diffraction, X-ray fluorescence, transmission electron microscopy, Fourier transform infrared spectroscopy, and polarized-light microscopy analyses. Clay mineral (CM) composition includes illite/muscovite (1M and 2M1 polytypes), illite–smectite interstratifications (IS-ml), smectite, and chlorite; and non-clay minerals such as quartz, feldspars, epidote, calcite, dolomite, and hematite were detected. The 2M1-polytype mica might be the only primary sheet silicates from the parent rocks, while the others occur as authigenic neo-formed CMs under heat flow and geothermal gradient. The development of CMs indicates different mechanisms of illitization and smectitization. Based on the texture, morphology, structure/polytype, and chemistry of rocks and minerals, in particular CMs, the study grouped the CM formation into three transformation processes: smectitization during magma cooling and possible contact metamorphisms with decreasing and low temperature, smectite illitization controlled by burial diagenesis and hydrothermal alteration, and illite smectitization followed exhumation and Cenozoic subsidence with decreasing temperature. The rhyolites were altered to all of the orders IS-R0, IS-R1, and IS-R3 by the dissolution-precipitation and layer-to-layer mechanisms. The first one supported small xenomorphic plates and flakes of 1Md, elongated particles of 1M, and pseudo-hexagonal forms of 2M1. The second one could lead to the platy particles of 1Md and 2M1 polytypes. The dominant temperature range for the transformation in the area has been 140–170 °C– ~ 230 °C., Technische Universität Darmstadt (3139)
- Published
- 2021
- Full Text
- View/download PDF
13. The Two‐Energies Turbulence Scheme Coupled to the Assumed PDF Method
- Author
-
Bašták Ďurán, Ivan, Sakradzija, Mirjana, Schmidli, Juerg, 2 Hans Ertel Centre for Weather Research Offenbach am Main Germany, and 1 Institute for Atmospheric and Environmental Sciences Goethe University Frankfurt Frankfurt am Main Germany
- Subjects
ddc:551.5 ,ddc:550.724 - Abstract
An update of the two‐energy turbulence scheme is presented, the 2TE + APDF scheme. The original version of the two‐energy scheme is able to successfully model shallow convection without the need of an additional parameterization for non‐local fluxes. However, the performance of the two‐energy scheme is worse in stratocumulus cases, where it tends to overestimate the erosion of the stable layers. We have identified the causes: the non‐local stability parameter does not consider local stratification, the scheme lacks an internal parameter that could distinguish between a shallow convection regime and a stratocumulus regime, and it uses an inflexible turbulence length scale formulation. To alleviate this problem, we propose several modifications: an update of the stability parameter, a modified computation of the turbulence length scale, and the introduction of the entropy potential temperature to distinguish between a shallow convection and a stratocumulus regime. In addition, the two‐energy scheme is coupled to a simplified assumed probability density function method in order to achieve a more universal representation of the cloudy regimes. The updated turbulence scheme is evaluated for several idealized cases and one selected real case in the ICOsahedral Nonhydrostatic (ICON) modeling framework. The results show that the updated scheme corrects the overmixing problem in the stratocumulus cases. The performance of the updated scheme is comparable to the operational setup, and can be thus used instead of the operational turbulence and shallow convection scheme in ICON. Additionally, the updated scheme improves the coupling with dynamics, which is beneficial for the modeling of coherent flow structures in the atmospheric boundary layer., Plain Language Summary: The two‐energy turbulence scheme parametrizes turbulence and boundary layer clouds in a unified framework. This enables the scheme to be more consistent and more continuous in time and space than the classical combination of separate turbulence and convection schemes. The original version of the scheme tends to overestimate the erosion of the stable layers, particularly in stratocumulus cases. We have identified several reasons for this problem and updated the scheme accordingly. To achieve a more universal representation of the cloudy regimes, the two‐energy scheme has been also coupled to the assumed probability density function (PDF) method. This method is based on assuming the shape of the trivariate PDF of moisture, heat and vertical velocity. The new version of the scheme was implemented into the ICOsahedral Nonhydrostatic (ICON) modeling framework and was tested on several idealized cases and one realistic case. The results show that the updated scheme corrects the overmixing problem in the stratocumulus cases. The performance of the updated scheme is comparable to the operational setup, and can be thus used instead of the operational turbulence and shallow convection scheme in ICON. Additionally, the updated scheme improves the coupling with dynamics, which is beneficial for the modeling of coherent flow structures in the atmospheric boundary layer., Key Points: An update of the two‐energy scheme for the unified parameterization of the turbulence and clouds in the atmospheric boundary layer (ABL) is presented. The performance of the updated scheme is comparable to the operational ICOsahedral Nonhydrostatic configuration. The updated scheme shows the ability to model coherent flow structures in the ABL., Hans Ertel Centre for Weather Research of DWD, Deutsche Forschungsgemeinschaft (DFG) http://dx.doi.org/10.13039/501100001659, https://zenodo.org/record/822842, https://doi.org/10.5281/zenodo.6403030
- Published
- 2022
14. Selective Delivery of Nitric Oxide to a Cellular Target: A Pseudosubstrate-Coupled Dinitrosyl–Iron Complex Inhibits the Enteroviral Protease 2A
- Author
-
Badorff, Cornel, Fichtlscherer, Birgit, Muelsch, Alexander, Zeiher, Andreas M., and Dimmeler, Stefanie
- Published
- 2002
- Full Text
- View/download PDF
15. Measurement of negatively charged pion spectra in inelastic p+p interactions at <math><mrow><msub><mi>p</mi><mi mathvariant='bold'>lab</mi></msub><mo>=</mo></mrow></math> 20, 31, 40, 80 and 158 GeV/c
- Author
-
Abgrall, N.University of Geneva, Geneva, Switzerland, Aduszkiewicz, A.(Faculty of Physics, University of Warsaw, Warsaw, Poland), Ali, Y.(Jagiellonian University, Cracow, Poland), Anticic, T.(Rudjer Bošković Institute, Zagreb, Croatia), Antoniou, N.(University of Athens, Athens, Greece), Baatar, B.(Joint Institute for Nuclear Research, Dubna, Russia), Bay, F.(ETH, Zurich, Switzerland), Blondel, A.(University of Geneva, Geneva, Switzerland), Blumer, J.(Karlsruhe Institute of Technology, Karlsruhe, Germany), Bogomilov, M.(Faculty of Physics, University of Sofia, Sofia, Bulgaria), Bravar, A.(University of Geneva, Geneva, Switzerland), Brzychczyk, J.(Jagiellonian University, Cracow, Poland), Bunyatov, S. A.(Joint Institute for Nuclear Research, Dubna, Russia), Busygina, O.(Institute for Nuclear Research, Moscow, Russia), Christakoglou, P.(University of Athens, Athens, Greece), Czopowicz, T.(Warsaw University of Technology, Warsaw, Poland), Davis, N.(University of Athens, Athens, Greece), Debieux, S.(University of Geneva, Geneva, Switzerland), Dembinski, H.(Karlsruhe Institute of Technology, Karlsruhe, Germany), Diakonos, F.(University of Athens, Athens, Greece), Luise, S. Di(ETH, Zurich, Switzerland), Dominik, W.(Faculty of Physics, University of Warsaw, Warsaw, Poland), Drozhzhova, T.(St. Petersburg State University, St. Petersburg, Russia), Dumarchez, J.(LPNHE, University of Paris VI and VII, Paris, France), Dynowski, K.(Warsaw University of Technology, Warsaw, Poland), Engel, R.(Karlsruhe Institute of Technology, Karlsruhe, Germany), Ereditato, A.(University of Bern, Bern, Switzerland), Feofilov, G. A.(St. Petersburg State University, St. Petersburg, Russia), Fodor, Z.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Fulop, A.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Gaździcki, M.(Jan Kochanowski University in Kielce, Kielce, Poland), Golubeva, M.(Institute for Nuclear Research, Moscow, Russia), Grebieszkow, K.(Warsaw University of Technology, Warsaw, Poland), Grzeszczuk, A.(University of Silesia, Katowice, Poland), Guber, F.(Institute for Nuclear Research, Moscow, Russia), Haesler, A.(University of Geneva, Geneva, Switzerland), Hasegawa, T.(High Energy Accelerator Research Organization (KEK), 305-0801, Tsukuba, Ibaraki, Japan), Hierholzer, M.(University of Bern, Bern, Switzerland), Idczak, R.(University of Wrocław, Wrocław, Poland), Igolkin, S.(St. Petersburg State University, St. Petersburg, Russia), Ivashkin, A.(Institute for Nuclear Research, Moscow, Russia), Joković, D.(University of Belgrade, Belgrade, Serbia), Kadija, K.(Rudjer Bošković Institute, Zagreb, Croatia), Kapoyannis, A.(University of Athens, Athens, Greece), Kaptur, E.(University of Silesia, Katowice, Poland), Kiełczewska, D.(Faculty of Physics, University of Warsaw, Warsaw, Poland), Kirejczyk, M.(Faculty of Physics, University of Warsaw, Warsaw, Poland), Kisiel, J.(University of Silesia, Katowice, Poland), Kiss, T.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Kleinfelder, S.(University of California, Irvine, USA), Kobayashi, T.(High Energy Accelerator Research Organization (KEK), 305-0801, Tsukuba, Ibaraki, Japan), Kolesnikov, V. I.(Joint Institute for Nuclear Research, Dubna, Russia), Kolev, D.(Faculty of Physics, University of Sofia, Sofia, Bulgaria), Kondratiev, V. P.(St. Petersburg State University, St. Petersburg, Russia), Korzenev, A.(University of Geneva, Geneva, Switzerland), Kovesarki, P.(University of Wrocław, Wrocław, Poland), Kowalski, S.(University of Silesia, Katowice, Poland), Krasnoperov, A.(Joint Institute for Nuclear Research, Dubna, Russia), Kurepin, A.(Institute for Nuclear Research, Moscow, Russia), Larsen, D.(University of Silesia, Katowice, Poland), László, A.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Lyubushkin, V. V.(Joint Institute for Nuclear Research, Dubna, Russia), Maćkowiak-Pawłowska, M.(University of Frankfurt, Frankfurt, Germany), Majka, Z.(Jagiellonian University, Cracow, Poland), Maksiak, B.(Warsaw University of Technology, Warsaw, Poland), Malakhov, A. I.(Joint Institute for Nuclear Research, Dubna, Russia), Manić, D.(University of Belgrade, Belgrade, Serbia), Marcinek, A.(Jagiellonian University, Cracow, Poland), Marin, V.(Institute for Nuclear Research, Moscow, Russia), Marton, K.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Mathes, H.-J.(Karlsruhe Institute of Technology, Karlsruhe, Germany), Matulewicz, T.(Faculty of Physics, University of Warsaw, Warsaw, Poland), Matveev, V.(Joint Institute for Nuclear Research, Dubna, Russia), Melkumov, G. L.(Joint Institute for Nuclear Research, Dubna, Russia), Mrówczyński, St.(Jan Kochanowski University in Kielce, Kielce, Poland), Murphy, S.(University of Geneva, Geneva, Switzerland), Nakadaira, T.(High Energy Accelerator Research Organization (KEK), 305-0801, Tsukuba, Ibaraki, Japan), Nirkko, M.(University of Bern, Bern, Switzerland), Nishikawa, K.(High Energy Accelerator Research Organization (KEK), 305-0801, Tsukuba, Ibaraki, Japan), Palczewski, T.(National Centre for Nuclear Research, Warsaw, Poland), Palla, G.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Panagiotou, A. D.(University of Athens, Athens, Greece), Paul, T.(Laboratory of Astroparticle Physics, University Nova Gorica, Nova Gorica, Slovenia), Pistillo, C.(University of Bern, Bern, Switzerland), Peryt, W.(Warsaw University of Technology, Warsaw, Poland), Petukhov, O.(Institute for Nuclear Research, Moscow, Russia), Płaneta, R.(Jagiellonian University, Cracow, Poland), Pluta, J.(Warsaw University of Technology, Warsaw, Poland), Popov, B. A.(Joint Institute for Nuclear Research, Dubna, Russia), Posiadała, M.(Faculty of Physics, University of Warsaw, Warsaw, Poland), Puławski, S.(University of Silesia, Katowice, Poland), Puzović, J.(University of Belgrade, Belgrade, Serbia), Rauch, W.(Fachhochschule Frankfurt, Frankfurt, Germany), Ravonel, M.(University of Geneva, Geneva, Switzerland), Redij, A.(University of Bern, Bern, Switzerland), Renfordt, R.(University of Frankfurt, Frankfurt, Germany), Robert, A.(LPNHE, University of Paris VI and VII, Paris, France), Röhrich, D.(University of Bergen, Bergen, Norway), Rondio, E.(National Centre for Nuclear Research, Warsaw, Poland), Roth, M.(Karlsruhe Institute of Technology, Karlsruhe, Germany), Rubbia, A.(ETH, Zurich, Switzerland), Rustamov, A.(University of Frankfurt, Frankfurt, Germany), Rybczyński, M.(Jan Kochanowski University in Kielce, Kielce, Poland), Sadovsky, A.(Institute for Nuclear Research, Moscow, Russia), Sakashita, K.(High Energy Accelerator Research Organization (KEK), 305-0801, Tsukuba, Ibaraki, Japan), Savić, M.(University of Belgrade, Belgrade, Serbia), Schmidt, K.(University of Silesia, Katowice, Poland), Sekiguchi, T.(High Energy Accelerator Research Organization (KEK), 305-0801, Tsukuba, Ibaraki, Japan), Seyboth, P.(Jan Kochanowski University in Kielce, Kielce, Poland), Sgalaberna, D.(ETH, Zurich, Switzerland), Shibata, M.(High Energy Accelerator Research Organization (KEK), 305-0801, Tsukuba, Ibaraki, Japan), Sipos, R.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Skrzypczak, E.(Faculty of Physics, University of Warsaw, Warsaw, Poland), Słodkowski, M.(Warsaw University of Technology, Warsaw, Poland), Staszel, P.(Jagiellonian University, Cracow, Poland), Stefanek, G.(Jan Kochanowski University in Kielce, Kielce, Poland), Stepaniak, J.(National Centre for Nuclear Research, Warsaw, Poland), Ströbele, H.(University of Frankfurt, Frankfurt, Germany), Šuša, T.(Rudjer Bošković Institute, Zagreb, Croatia), Szuba, M.(Karlsruhe Institute of Technology, Karlsruhe, Germany), Tada, M.(High Energy Accelerator Research Organization (KEK), 305-0801, Tsukuba, Ibaraki, Japan), Tereshchenko, V.(Joint Institute for Nuclear Research, Dubna, Russia), Tolyhi, T.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Tsenov, R.(Faculty of Physics, University of Sofia, Sofia, Bulgaria), Turko, L.(University of Wrocław, Wrocław, Poland), Ulrich, R.(Karlsruhe Institute of Technology, Karlsruhe, Germany), Unger, M.(Karlsruhe Institute of Technology, Karlsruhe, Germany), Vassiliou, M.(University of Athens, Athens, Greece), Veberič, D.(Laboratory of Astroparticle Physics, University Nova Gorica, Nova Gorica, Slovenia), Vechernin, V. V.(St. Petersburg State University, St. Petersburg, Russia), Vesztergombi, G.(KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary), Vinogradov, L.(St. Petersburg State University, St. Petersburg, Russia), Wilczek, A.(University of Silesia, Katowice, Poland), Włodarczyk, Z.(Jan Kochanowski University in Kielce, Kielce, Poland), Wojtaszek-Szwarc, A.(Jan Kochanowski University in Kielce, Kielce, Poland), Wyszyński, O.(Jagiellonian University, Cracow, Poland), Zambelli, L.(LPNHE, University of Paris VI and VII, Paris, France), and Zipper, W.(University of Silesia, Katowice, Poland)
- Subjects
Nuclear Theory ,High Energy Physics::Experiment ,Nuclear Experiment - Abstract
We present experimental results on inclusive spectra and mean multiplicities of negatively charged pions produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158 GeV/ c ( s= 6.3, 7.7, 8.8, 12.3 and 17.3 GeV, respectively). The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN super proton synchrotron. Two-dimensional spectra are determined in terms of rapidity and transverse momentum. Their properties such as the width of rapidity distributions and the inverse slope parameter of transverse mass spectra are extracted and their collision energy dependences are presented. The results on inelastic p+p interactions are compared with the corresponding data on central Pb+Pb collisions measured by the NA49 experiment at the CERN SPS. The results presented in this paper are part of the NA61/SHINE ion program devoted to the study of the properties of the onset of deconfinement and search for the critical point of strongly interacting matter. They are required for interpretation of results on nucleus–nucleus and proton–nucleus collisions.
- Published
- 2014
16. How Family Status and Social Security Claiming Options Shape Optimal Life Cycle Portfolios
- Author
-
Goethe University of Frankfurt, The Wharton School, University of Pennsylvania, Ann Arbor, Hubener, Andreas, Maurer, Raimond, Mitchell, Olivia S., Goethe University of Frankfurt, The Wharton School, University of Pennsylvania, Ann Arbor, Hubener, Andreas, Maurer, Raimond, and Mitchell, Olivia S.
- Abstract
Household decisions are profoundly shaped by a complex set of financial options due to Social Security rules determining retirement, spousal, and survivor benefits, along with benefit adjustments that vary with the age at which these are claimed. These rules influence optimal household asset allocation, insurance, and work decisions, given life cycle demographic shocks such as marriage, divorce, and children. Our model generates a wealth profile and a low and stable equity fraction consistent with empirical evidence. We also confirm predictions that wives will claim retirement benefits earlier than husbands, while life insurance is mainly purchased by younger men. Our policy simulations imply that eliminating survivor benefits would sharply reduce claiming differences by sex while dramatically increasing men???s life insurance purchases.
- Published
- 2014
17. ‘Discursive encounter’ between the European Union and Nigeria: performing the agency of ECOWAS as a regional security actor
- Author
-
Workshop Performativity and Agency in International Politics (22-24 février 2014: University of Frankfurt), Lopez Lucia, Elisa, Workshop Performativity and Agency in International Politics (22-24 février 2014: University of Frankfurt), and Lopez Lucia, Elisa
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2014
18. The CYP450 Mouse Model for Autoimmune Hepatitis: Breaking of Self-Tolerance in Transgenic CYP2D6 and Wildtype FVB-Mice by Viral Infection
- Author
-
Christen, Urs, Holdener, Martin, Hintermann, Edith, von Herrath, Matthias, and Manns, Michael
- Published
- 2007
- Full Text
- View/download PDF
19. Activation of Hepatic Stellate Cells During Fibrosis: Comparison of the CYP2D6 Model for Autoimmune Hepatitis and CCl4 Injection
- Author
-
Christen, Urs, Hintermann, Edith, Bayer, Monika, and Christen, Selina
- Published
- 2007
- Full Text
- View/download PDF
20. Recycling Potential in Endoscopy - a Multicentre Prospective Observational Study
- Author
-
Georg Dultz, Goethe University Hospital Frankfurt
- Published
- 2023
21. The dynamical association between physical activity and affect in the daily life of individuals with ADHD
- Author
-
Elena D. Koch, Christine M. Freitag, Jutta S. Mayer, Juliane Medda, Andreas Reif, Oliver Grimm, Josep A. Ramos-Quiroga, Judit Palacio Sanchez, Philip Asherson, Jonna Kuntsi, Adam D. Pawley, Jan K. Buitelaar, Douwe Bergsma, Francisco B. Ortega, Adria Muntaner-Mas, Iris Reinhard, Markus Reichert, Marco Giurgiu, Ulrich W. Ebner-Priemer, Institut Català de la Salut, [Koch ED] Mental mHealth Lab, Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. B Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany. [Freitag CM, Mayer JS, Medda J] Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany. [Reif A, Grimm O] Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany. [Ramos-Quiroga JA, Palacions Sanchez J] Servei de Psiquiatria, Vall d'Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
Adult ,Exercici ,Cognition ,Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity [PSYCHIATRY AND PSYCHOLOGY] ,130 000 Cognitive Neurology & Memory ,Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Movement::Motor Activity::Exercise [PHENOMENA AND PROCESSES] ,Mood ,Humans ,ADHD ,Pharmacology (medical) ,ddc:796 ,Afecte (Psicologia) ,Exercise ,Biological Psychiatry ,Pharmacology ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Physical activity ,Behavior and Behavior Mechanisms::Emotions::Affect [PSYCHIATRY AND PSYCHOLOGY] ,Ambulatory assessment ,Psychiatry and Mental health ,conducta y mecanismos de la conducta::emociones::afecto [PSIQUIATRÍA Y PSICOLOGÍA] ,Affect ,Trastorn per dèficit d'atenció amb hiperactivitat ,Athletic & outdoor sports & games ,Neurology ,Attention Deficit Disorder with Hyperactivity ,fenómenos fisiológicos nerviosos y musculoesqueléticos::fenómenos fisiológicos musculoesqueléticos::movimiento::actividad motora::ejercicio físico [FENÓMENOS Y PROCESOS] ,Neurology (clinical) ,trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad [PSIQUIATRÍA Y PSICOLOGÍA] - Abstract
Exercise interventions in mental disorders have evidenced a mood-enhancing effect. However, the association between physical activity and affect in everyday life has not been investigated in adult individuals with ADHD, despite being important features of this disorder. As physical activity and affect are dynamic processes in nature, assessing those in everyday life with e- diaries and wearables, has become the gold standard. Thus, we used an mHealth approach to prospectively assess physical activity and affect processes in individuals with ADHD and con- trols aged 14–45 years. Participants wore accelerometers across a four-day period and reported their affect via e-diaries twelve times daily. We used multilevel models to identify the within- subject effects of physical activity on positive and negative affect. We split our sample into three groups: 1. individuals with ADHD who were predominantly inattentive ( n = 48), 2. in- dividuals with ADHD having a combined presentation (i.e., being inattentive and hyperactive; n = 95), and 3. controls ( n = 42). Our analyses revealed a significant cross-level interaction (F(2, 135.072) = 5.733, p = 0.004) of physical activity and group on positive affect. In details, all groups showed a positive association between physical activity and positive affect. Indi- viduals with a combined presentation significantly showed the steepest slope of physical ac- tivity on positive affect (slope_inattentive = 0.005, p < 0.001; slope_combined = 0.009, p < 0.001; slope_controls = 0.004, p = 0.008). Our analyses on negative affect revealed a negative associ- ation only in the individuals with a combined presentation (slope = -0.003; p = 0.001). Whether this specifically pronounced association in individuals being more hyperactive might be a mech- anism reinforcing hyperactivity needs to be empirically clarified in future studies., European Commission 667302, ECNP Network
- Published
- 2022
22. Whole-exome sequencing of 81 individuals from 27 multiply affected bipolar disorder families
- Author
-
Fermín Mayoral, Fabio Rivas, Jesus Haro González, Franziska Degenhardt, Julian Hecker, Fermin Perez Perez, Marcella Rietschel, Michael Bauer, Margot Albus, Markus M. Nöthen, Sascha B. Fischer, Susana Gil Flores, Francisco del Río Noriega, Mehdi Pirooznia, Stefan Herms, Jana Strohmaier, Stephanie H. Witt, Fernando S. Goes, Margitta Borrmann-Hassenbach, Anna Maaser-Hecker, Sugirthan Sivalingam, Sven Cichon, Lorena M. Schenk, Georg Auburger, Andreas Reif, Fabian Streit, María González, Francisco J. Cabaleiro Fabeiro, Peter Nürnberg, Jose Guzman-Parra, Andreas J. Forstner, Holger Thiele, Guillermo Orozco Diaz, Andrea Pfennig, Céline S. Reinbold, Johannes Schumacher, Per Hoffmann, [Forstner,AJ, Schumacher,J] Centre for Human Genetics, University of Marburg, Marburg, Germany. [Forstner,AJ, Schenk,LM, Maaser-Hecker,A, Sivalingam,S, Degenhardt,F, Schumacher,J, Herms,S, Hoffmann,P, Nöthen,MM, Cichon,S] Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany. [Forstner,AJ, Fischer,SB, Reinbold,CS, Cichon,S] Department of Biomedicine, University of Basel, Basel, Switzerland. [Forstner,AJ] Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. [Fischer,SB, Cichon,S] Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. [Strohmaier,J, Streit,F, Witt,SH, Rietschel,M] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. [Strohmaier,J] SRH University Heidelberg, Academy for Psychotherapy, Heidelberg, Germany. [Reinbold,CS] Center for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology, University of Oslo, Oslo, Norway. [Hecker,J] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. [Thiele,H, Nürnberg,P] Cologne Center for Genomics, University of Cologne, Cologne, Germany. [Guzman-Parra,J, González,MJ] Department of Mental Health, University Regional Hospital of Málaga, Institute of Biomedicine of Málaga (IBIMA), Málaga, Spain. [Orozco Diaz,G] Unidad de Gestión Clínica del Dispositivo de Cuidados Críticos y Urgencias del Distrito Sanitario Málaga - Coin- Gudalhorce, Málaga, Spain. [Auburger,G] Experimental Neurology, Department of Neurology, Goethe University Hospital, Frankfurt am Main, Germany. [Albus,M, Borrmann-Hassenbach,M]Isar Amper Klinikum München Ost, kbo, Haar, Germany. [Gil Flores,S] Department of Mental Health, University Hospital of Reina Sofia, Cordoba, Spain. [Cabaleiro Fabeiro,FJ] Department of Mental Health, Hospital of Jaén, Jaén, Spain. [del Río Noriega,F] Department of Mental Health, Hospital of Jerez de la Frontera, Jerez de la Frontera, Spain. [Perez Perez,F] Department of Mental Health, Hospital of Puerto Real, Cádiz, Spain. [Haro González,J] Department of Mental Health, Hospital Punta de Europa, Algeciras, Spain. [Rivas,F, Mayoral,F] Department of Psychiatry, Carlos Haya Regional University Hospital, Malaga, Spain. [Bauer,M, Pfennig,A] Department of Psychiatry and Psychotherapy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. [Reif,A] Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany. [Hoffmann,P, Cichon,S] Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany. [Pirooznia,M, Goes,FS] Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The study was supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme (grant 01ZX1314A/01ZX1614A to M.M.N. Forstner et al. Translational Psychiatry (2020) 10:57 Page 8 of 10 and S.C., grant 01ZX1314G/01ZX1614G to M.R.) and through ERA-NET NEURON, 'SynSchiz—Linking synaptic dysfunction to disease mechanisms in schizophrenia—a multilevel investigation' (01EW1810 to MR). The study was also supported by the German Research Foundation (DFG, grant FOR2107, RI908/11-1 and RI908/11–2 to M.R., and NO246/10-1 and NO 246/10-2 to M.M.N.), and the Swiss National Science Foundation (SNSF, grant 156791 to S.C.). M.M.N. is a member of the DFG-funded Excellence-Cluster ImmunoSensation.
- Subjects
Candidate gene ,Bipolar Disorder ,Psychiatry and Psychology::Mental Disorders::Mood Disorders::Affective Disorders, Psychotic::Bipolar Disorder [Medical Subject Headings] ,Neuropsiquiatría ,Disease ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,0302 clinical medicine ,Germany ,Exome ,Exome sequencing ,Genetics ,0303 health sciences ,Trastorno bipolar ,Predisposición genética a la enfermedad ,Neuropsychiatry ,Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease [Medical Subject Headings] ,3. Good health ,Pedigree ,Psychiatry and Mental health ,Schizophrenia ,Phenomena and Processes::Genetic Phenomena::Inheritance Patterns::Penetrance [Medical Subject Headings] ,Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Child Development Disorders, Pervasive::Autistic Disorder [Medical Subject Headings] ,Biology ,Molecular neuroscience ,Article ,Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Exome [Medical Subject Headings] ,lcsh:RC321-571 ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Exome Sequencing ,medicine ,Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia [Medical Subject Headings] ,Humans ,Genetic Predisposition to Disease ,Bipolar disorder ,ddc:610 ,Allele ,Gene ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Biological Psychiatry ,030304 developmental biology ,Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings] ,Secuenciación del exoma completo ,Whole exome sequencing ,Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings] ,medicine.disease ,Geographical Locations::Geographic Locations::Europe::Germany [Medical Subject Headings] ,Autism ,030217 neurology & neurosurgery ,RGS Proteins - Abstract
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of depression and mania. Research suggests that the cumulative impact of common alleles explains 25–38% of phenotypic variance, and that rare variants may contribute to BD susceptibility. To identify rare, high-penetrance susceptibility variants for BD, whole-exome sequencing (WES) was performed in three affected individuals from each of 27 multiply affected families from Spain and Germany. WES identified 378 rare, non-synonymous, and potentially functional variants. These spanned 368 genes, and were carried by all three affected members in at least one family. Eight of the 368 genes harbored rare variants that were implicated in at least two independent families. In an extended segregation analysis involving additional family members, five of these eight genes harbored variants showing full or nearly full cosegregation with BD. These included the brain-expressed genes RGS12 and NCKAP5, which were considered the most promising BD candidates on the basis of independent evidence. Gene enrichment analysis for all 368 genes revealed significant enrichment for four pathways, including genes reported in de novo studies of autism (padj padj = 0.015). These results suggest a possible genetic overlap with BD for autism and schizophrenia at the rare-sequence-variant level. The present study implicates novel candidate genes for BD development, and may contribute to an improved understanding of the biological basis of this common and often devastating disease.
- Published
- 2020
- Full Text
- View/download PDF
23. Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis
- Author
-
Jonel Trebicka, Alex Amoros, Carla Pitarch, Esther Titos, José Alcaraz-Quiles, Robert Schierwagen, Carmen Deulofeu, Javier Fernandez-Gomez, Salvatore Piano, Paolo Caraceni, Karl Oettl, Elsa Sola, Wim Laleman, Jane McNaughtan, Rajeshwar P. Mookerjee, Minneke J. Coenraad, Tania Welzel, Christian Steib, Rita Garcia, Thierry Gustot, Miguel A. Rodriguez Gandia, Rafael Bañares, Agustin Albillos, Stefan Zeuzem, Victor Vargas, Faouzi Saliba, Frederic Nevens, Carlo Alessandria, Andrea de Gottardi, Heinz Zoller, Pere Ginès, Tilman Sauerbruch, Alexander Gerbes, Rudolf E. Stauber, Mauro Bernardi, Paolo Angeli, Marco Pavesi, Richard Moreau, Joan Clària, Rajiv Jalan, Vicente Arroyo, Institut Català de la Salut, [Trebicka J] European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain. Department of Internal Medicine I, University of Bonn, Bonn, Germany. Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. Department of Mechanical Biology, Institute for Bioengineering of Catalonia, Barcelona, Spain. J.W. Goethe University Hospital, Frankfurt, Germany. [Amoros A, Pitarch C] European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain. [Titos E, Alcaraz-Quiles J] Department of Biochemistry and Molecular Genetics, Hospital Clínic, Barcelona, Spain. [Schierwagen R] Department of Internal Medicine I, University of Bonn, Bonn, Germany. J.W. Goethe University Hospital, Frankfurt, Germany. [Vargas V] Hospital Universitari Vall d'Hebron, Barcelona, Spain., Vall d'Hebron Barcelona Hospital Campus, Lucas, Rudolf, CANONIC Study Investigators of the EASL-CLIF Consortium the European Foundation for the Study of Chronic Liver Failure (EF-CLIF), Universitat de Barcelona, Trebicka J., Amoros A., Pitarch C., Titos E., Alcaraz-Quiles J., Schierwagen R., Deulofeu C., Fernandez-Gomez J., Piano S., Caraceni P., Oettl K., Sola E., Laleman W., McNaughtan J., Mookerjee R.P., Coenraad M.J., Welzel T., Steib C., Garcia R., Gustot T., Rodriguez Gandia M.A., Banares R., Albillos A., Zeuzem S., Vargas V., Saliba F., Nevens F., Alessandria C., De Gottardi A., Zoller H., Gines P., Sauerbruch T., Gerbes A., Stauber R.E., Bernardi M., Angeli P., Pavesi M., Moreau R., Claria J., Jalan R., and Arroyo V.
- Subjects
0301 basic medicine ,Other subheadings::Other subheadings::Other subheadings::/blood [Other subheadings] ,CHRONIC LIVER-FAILURE ,Liver Cirrhosis ,Male ,Chemokine ,Cirrhosis ,ALCOHOLIC HEPATITIS ,enfermedades del sistema digestivo::enfermedades hepáticas::cirrosis hepática [ENFERMEDADES] ,Digestive System Diseases::Liver Diseases::Liver Cirrhosis [DISEASES] ,Systemic inflammation ,Gastroenterology ,Severity of Illness Index ,factores biológicos::biomarcadores [COMPUESTOS QUÍMICOS Y DROGAS] ,chemistry.chemical_compound ,0302 clinical medicine ,ACLF ,Immunology and Allergy ,610 Medicine & health ,Original Research ,RISK ,biology ,Malalties del fetge ,Sciences bio-médicales et agricoles ,Middle Aged ,Prognosis ,Phenotype ,Inflamació ,Hepatic cirrhosis ,Creatinine ,Marcadors bioquímics ,SURVIVAL ,Cytokines ,Female ,medicine.symptom ,Otros calificadores::Otros calificadores::Otros calificadores::/sangre [Otros calificadores] ,Life Sciences & Biomedicine ,signature ,lcsh:Immunologic diseases. Allergy ,medicine.medical_specialty ,Cirrosi hepàtica ,Immunology ,PORTAL-HYPERTENSION ,Inflammation ,ALBUMIN ,enfermedades del sistema digestivo::enfermedades hepáticas::insuficiencia hepática::fracaso hepático::fracaso hepático agudo::insuficiencia hepática crónica agudizada [ENFERMEDADES] ,Biological Factors::Biomarkers [CHEMICALS AND DRUGS] ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,organ failure ,ddc:610 ,acute decompensation ,cirrhosis ,organ dysfunction ,Liver diseases ,Aged ,Cirrhosi ,Science & Technology ,business.industry ,MORTALITY ,Organ dysfunction ,Albumin ,Digestive System Diseases::Liver Diseases::Hepatic Insufficiency::Liver Failure::Liver Failure, Acute::Acute-On-Chronic Liver Failure [DISEASES] ,Acute-On-Chronic Liver Failure ,medicine.disease ,030104 developmental biology ,chemistry ,biology.protein ,Insuficiència hepàtica ,PENTOXIFYLLINE ,business ,lcsh:RC581-607 ,Biomarkers ,030215 immunology - Abstract
Background: Patients with acutely decompensated cirrhosis (AD) may or may not develop acute-on-chronic liver failure (ACLF). ACLF is characterized by high-grade systemic inflammation, organ failures (OF) and high short-term mortality. Although patients with AD cirrhosis exhibit distinct clinical phenotypes at baseline, they have low short-term mortality, unless ACLF develops during follow-up. Because little is known about the association of profile of systemic inflammation with clinical phenotypes of patients with AD cirrhosis, we aimed to investigate a battery of markers of systemic inflammation in these patients. Methods: Upon hospital admission baseline plasma levels of 15 markers (cytokines, chemokines, and oxidized albumin) were measured in 40 healthy controls, 39 compensated cirrhosis, 342 AD cirrhosis, and 161 ACLF. According to EASL-CLIF criteria, AD cirrhosis was divided into three distinct clinical phenotypes (AD-1: Creatinine, SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2019
- Full Text
- View/download PDF
24. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
- Author
-
Geraldine Dawson, Sven Sandin, Frederico Duque, Peter Holmans, Marion Leboyer, Aarno Palotie, Fritz Poustka, Richard Delorme, Stephen Sanders, Alistair T. Pagnamenta, Lonnie Zwaigenbaum, Bridget A. Fernandez, A. Jeremy Willsey, Christine M. Freitag, Christa Lese Martin, Elena Maestrini, Elena Bacchelli, Guiomar Oliveira, Jeremy R. Parr, Guy A. Rouleau, Jonas Bybjerg-Grauholm, Joseph Piven, Latha Soorya, Lauren A. Weiss, Jonathan Green, Carsten Bøcker Pedersen, Louise Gallagher, Regina Regan, Stephan Ripke, Thomas Werge, Pat Levitt, Aravinda Chakravarti, Joana Almeida, Kathryn Roeder, Catalina Betancur, Bernie Devlin, Benjamin M. Neale, Gillian Baird, Jakob Grove, Thomas Bourgeron, David H. Ledbetter, Eftichia Duketis, Karola Rehnström, Gerard D. Schellenberg, Jillian P. Casey, Preben Bo Mortensen, Patrick Bolton, Igor Martsenkovsky, Elise Robinson, Hakon Hakonarson, Vanessa H. Bal, Stacy Steinberg, Christopher Gillberg, Kathryn Tsang, Jacob A. S. Vorstman, Verneri Anttila, Suma Jacob, Judith Conroy, J. Haines, William M. McMahon, Edwin H. Cook, Ann P. Thompson, Inês C. Conceição, Mark J. Daly, Arthur P. Goldberg, Sarah E. Medland, Milica Pejovic-Milovancevic, David M. Hougaard, Shrikant Mane, Christina M. Hultman, Susana Mouga, Hreinn Stefansson, Ellen M. Wijsman, Andreas G. Chiocchetti, Ole Mors, Phil Lee, Richard Anney, Astrid M. Vicente, Veronica J. Vieland, K. Stefansson, Stephen W. Scherer, Teimuraz Silagadze, Pall Magnusson, Donna M. Martin, Merete Nordentoft, Peter Szatmari, Patrícia B. S. Celestino-Soper, Ann S Le-Couteur, Cátia Café, Arthur L. Beaudet, Kerstin Wittemeyer, Anders D. Børglum, Joel S. Bader, Christopher S. Poultney, Hailiang Huang, Alexander Kolevzon, Margaret A. Pericak-Vance, Joachim Hallmayer, Rita M. Cantor, Eric Fombonne, Andrew Green, Dan E. Arking, M. Daniele Fallin, Matthew W. State, Christine Ladd-Acosta, Silvia Derubeis, Raphael Bernier, Regina Waltes, David G. Amaral, Manuel Mattheisen, Abraham Reichenberg, Lambertus Klei, Daniel Moreno-De-Luca, Marie Bækvad-Hansen, Maretha V. Dejonge, Susan G. McGrew, Joseph D. Buxbaum, Hilary Coon, Jennifer Reichert, Michael Gill, Herman Vanengeland, Christine Søholm Hansen, Anthony P. Monaco, Nadia Bolshakova, John I. Nurnberger, Nancy J. Minshew, Michael T. Murtha, Thomas H. Wassink, Evald Saemundsen, Simon Wallace, Sean Brennan, Sean Ennis, A. Gulhan Ercan-Sencicek, Sven Bölte, Oscar Svantesson, Susan L. Santangelo, Andrew D. Paterson, Robert L. Hendren, Timothy W. Yu, Dalila Pinto, D.E. Grice, Alison Merikangas, Stephen J. Guter, Anthony J. Bailey, Bernadette Rogé, Christopher A. Walsh, Susan E. Folstein, Wendy Roberts, Sabine M. Klauck, Marianne Giørtz Pedersen, Tiago R. Magalhaes, John R. Gilbert, Irva Hertz-Picciotto, James S. Sutcliffe, Evdokia Anagnostou, Catarina Correia, Eric M. Morrow, Daniel H. Geschwind, Jennifer K. Lowe, Agatino Battaglia, Bozenna Iliadou, Michael L. Cuccaro, Catherine Lord, MRC Centre for Neuropsychiatric Genetics and Genomics [Cardiff, UK], Cardiff University, The Autism Working Group of the Psychiatric Genomics Consortium was supported by National Institutes of Mental Health (NIMH, USA) grant MH109539, MH094432 and MH094421 to M.J.D. The ACE Network was supported by MH081754 and MH100027 to D.H.G. The Autism Genetic Resource Exchange (AGRE) is a program of Autism Speaks (USA) and was supported by grant MH081810. The Autism Genome Project (AGP) was supported by grants from Autism Speaks, the Canadian Institutes of Health Research (CIHR), Genome Canada, the Health Research Board (Ireland, AUT/ 2006/1, AUT/2006/2, PD/2006/48), the Hilibrand Foundation (USA), the Medical Research Council (UK), the National Institutes of Health (USA, the National Institute of Child Health and Human Development and the National Institute of Mental Health), the Ontario Genomics Institute, and the University of Toronto McLaughlin Centre. The Simons Simplex Collection (SSC) was supported by a grant from the Simons Foundation (SFARI 124827 to the investigators of the Simons Simplex Collection Genetic Consortium), approved researchers can obtain the SSC population dataset described in this study (http://sfari.org/resources/sfari-base) by applying at https://base.sfari.org. The Gene Discovery Project of Johns Hopkins was funded by MH060007, MH081754, and the Simons Foundation. The MonBos Collection study was funded in part through a grant from the Autism Consortium of Boston. Support for the Extreme Discordant Sib-Pair (EDSP) family sample (part of the MonBos collection) was provided by the NLM Family foundation. Support for the Massachusetts General Hospital (MGH)–Finnish collaborative sample was provided by NARSAD. The PAGES collection was funded by NIMH grant MH097849. The collection of data and biomaterials that participated in the NIMH Autism Genetics Initiative has been supported by National Institute of Health grants MH52708, MH39437, MH00219, and MH00980, National Health Medical Research Council grant 0034328, and by grants from the Scottish Rite, the Spunk Fund, Inc., the Rebecca and Solomon Baker Fund, the APEX Foundation, the National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD), the endowment fund of the Nancy Pritzker Laboratory (Stanford), and by gifts from the Autism Society of America, the Janet M. Grace Pervasive Developmental Disorders Fund, and families and friends of individuals with autism. The iPSYCH project is funded by The Lundbeck Foundation and the universities and university hospitals of Aarhus and Copenhagen. In addition, the genotyping of iPSYCH samples was supported by grants from the Stanley Foundation, the Simons Foundation (SFARI 311789 to MJD), and NIMH (5U01MH094432-02 to MJD). The Study to Explore Early Development (SEED) was funded by the Centers for Disease Control and Prevention (CDC) grants U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, and U10DD000498. Statistical analyses were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and financially supported by the Netherlands Scientific Organization (NWO 480-05-003), along with a supplement from the Dutch Brain Foundation and the VU University Amsterdam. Additional statistical analyses were performed and supported by the Trinity Centre for High Performance Computing (http://www.tchpc.tcd.ie/) funded through Science Foundation Ireland. Computational support for the PAGES collection was provided in part through the computational resources and staff expertise of the Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai (https://hpc.mssm.edu). Data QC and statistical analyses of the iPSYCH samples were performed at the high-performance computing cluster GenomeDK (http://genome.au.dk) at the Center for Integrative Sequencing, iSEQ, Aarhus University. iSEQ provided computed time, data storage, and technical support for the study., Richard JL Anney, Email: anneyr@cardiff.ac.uk, Affiliation/s: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK, Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Stephan Ripke, Email: ripke@atgu.mgh.harvard.edu, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin 10117, Germany. Verneri Anttila, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Jakob Grove, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK-8000, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark, Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. Peter Holmans, Affiliation/s: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK. Hailiang Huang, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Lambertus Klei, Affiliation/s: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Phil H Lee, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA. Sarah E Medland, Affiliation/s: Queensland Institute of Medical Research Brisbane, QLD, 4006, Australia. Benjamin Neale, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Elise Robinson, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Lauren A Weiss, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, Inst Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Lonnie Zwaigenbaum, Affiliation/s: Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 1C9, Canada. Timothy W Yu, Affiliation/s: Division of Genetics, Children ’ s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. Kerstin Wittemeyer, Affiliation/s: School of Education, University of Birmingham, Birmingham, B15 2TT, UK. A.Jeremy Willsey, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Ellen M Wijsman, Affiliation/s: Department of Medicine, University of Washington, Seattle, WA 98195, USA, Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Thomas Werge, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Institute of Biological Psychiatry, MHC Sct Hans, Mental Health Services Copenhagen, Roskilde, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK-2200, Denmark. Thomas H Wassink, Affiliation/s: Department of Psychiatry, Carver College of Medicine, Iowa City, IA 52242, USA. Regina Waltes, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Christopher A Walsh, Affiliation/s: Division of Genetics, Children ’ s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA, Program in Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA, Simon Wallace, Affiliation/s: Department of Psychiatry, University of Oxford and Warneford Hospital, Oxford, OX3 7JX, UK. Jacob AS Vorstman, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Veronica J Vieland, Affiliation/s: Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children ’ s Hospital, Columbus, OH 43205, USA. Astrid M Vicente, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Herman vanEngeland, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Kathryn Tsang, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, Inst Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Ann P Thompson, Affiliation/s: Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, L8S 4L8, Canada. Peter Szatmari, Affiliation/s: Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada. Oscar Svantesson, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Stacy Steinberg, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Kari Stefansson, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Hreinn Stefansson, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Matthew W State, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Latha Soorya, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Rush University Medical Center, Chicago, IL 60612, USA. Teimuraz Silagadze, Affiliation/s: Department of Psychiatry and Drug Addiction, Tbilisi State Medical University, Tbilisi, 0186, Georgia. Stephen W Scherer, Affiliation/s: The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada, McLaughlin Centre, University of Toronto, Toronto, ON, M5G 0A4, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. Gerard D Schellenberg, Affiliation/s: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19102, USA. Sven Sandin, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Stephan J Sanders, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Evald Saemundsen, Affiliation/s: State Diagnostic and Counseling Centre, Kopavogur, IS-201, Iceland. Guy A Rouleau, Affiliation/s: Montreal Neurological Institute, Dept of Neurology and Neurosurgery, McGill University, Montreal, QC, H3A 2B4, Canada. Bernadette Rogé, Affiliation/s: Centre d ’ Etudes et de Recherches en Psychopathologie, Toulouse University, Toulouse, 31058, France. Kathryn Roeder, Affiliation/s: Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Wendy Roberts, Affiliation/s: Autism Research Unit, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada. Jennifer Reichert, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Abraham Reichenberg, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Karola Rehnström, Affiliation/s: Sanger Institute, Hinxton, CB10 1SA, UK. Regina Regan, Affiliation/s: National Childrens Research Centre, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Fritz Poustka, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Christopher S Poultney, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Joseph Piven, Affiliation/s: University of North Carolina, Chapel Hill, NC 27599, USA. Dalila Pinto, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Margaret A Pericak-Vance, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Milica Pejovic-Milovancevic, Affiliation/s: Institute of Mental Health and Medical Faculty, University of Belgrade, Belgrade, 11 000, Serbia. Marianne Giørtz Pedersen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, National Centre for Register-based Research, Aarhus University, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark. Carsten Bøcker Pedersen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark. Andrew D Paterson, Affiliation/s: Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada, Dalla Lana School of Public Health, Toronto, ON, M5T 3M7, Canada. Jeremy R Parr, Affiliation/s: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK, Institue of Health and Science, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. Alistair T Pagnamenta, Affiliation/s: Wellcome Trust Centre for Human Genetics, OxfordUniversity,Oxford,OX37BN,UK. Guiomar Oliveira, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. John I Nurnberger, Affiliation/s: Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA, Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Merete Nordentoft, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark. Michael T Murtha, Affiliation/s: Programs on Neurogenetics, Yale University School of Medicine, New Haven, CT 06520, USA. Susana Mouga, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. Preben Bo Mortensen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Na- tional Centre for Register-based Research, Aarhus University, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark, Ole Mors, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark. Eric M Morrow, Affiliation/s: Department of Psychiatry and Human Behaviour, Brown University, Providence, RI 02912, USA. Daniel Moreno-De-Luca, Affiliation/s: Department of Psychiatry and Hu- man Behaviour, Brown University, Providence, RI 02912, USA. Anthony P Monaco, Affiliation/s: Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, UK, Tufts University, Boston, MA 02155?, USA. Nancy Minshew, Affiliation/s: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Alison Merikangas, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. William M McMahon, Affiliation/s: Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. Susan G McGrew, Affiliation/s: Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA. Manuel Mattheisen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark. Igor Martsenkovsky, Affiliation/s: Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social Fo- rensic Psychiatry and Drug Abuse, Kyiv, 04080, Ukraine. Donna M Martin, Affiliation/s: Department of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Shrikant M Mane, Affiliation/s: Yale Center for Genomic Analysis, Yale University School of Medicine, New Haven, CT 06516, USA. Pall Magnusson, Affiliation/s: Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, IS-101, Iceland. Tiago Magalhaes, Affiliation/s: National Childrens Research Centre, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Elena Maestrini, Affiliation/s: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy. Jennifer K Lowe, Affiliation/s: Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA, Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Catherine Lord, Affiliation/s: Department of Psychiatry, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. Pat Levitt, Affiliation/s: Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA. Christa LeseMartin, Affiliation/s: Autism and Developmental Medicine Institute, Geisinger Health System, Danville, PA 17837, USA. David H Ledbetter, Affiliation/s: Chief Scientific Officer, Geisinger Health System, Danville, PA 17837, USA. Marion Leboyer, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, INSERM U955, Paris, 94010, France, Faculté de Médecine, Université Paris Est, Créteil, 94000, France, Department of Psychiatry, Henri Mondor-Albert Chene- vier Hospital, Assistance Publique – Hôpitaux de Paris, Créteil, 94000, France, Ann S LeCouteur, Affiliation/s: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK, Institue of Health and Science, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. Christine Ladd-Acosta, Affiliation/s: Department of Epidemiology, Johns Hop- kins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Alexander Kolevzon, Affiliation/s: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Sabine M Klauck, Affiliation/s: Division of Molecular Genome Analysis and Working Group Cancer Genome Research, Deutsches Krebsforschungszentrum, Heidelberg, D-69120, Germany. Suma Jacob, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA, Institute of Translational Neuroscience and Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA. Bozenna Iliadou, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Christina M Hultman, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. David M Hougaard, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Irva Hertz-Picciotto, Affiliation/s: Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA 95616, USA, The MIND Institute, School of Medicine, University of California Davis, Davis, CA 95817, USA. Robert Hendren, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Christine Søholm Hansen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Jonathan L Haines, Affiliation/s: Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. Stephen J Guter, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA. Dorothy E Grice, Affiliation/s: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Jonathan M Green, Affiliation/s: Manchester Academic Health Sciences Centre, Manchester, M13 9NT, UK, Institute of Brain, Behaviour, and Mental Health, University of Manchester, Manchester, M13 9PT, UK. Andrew Green, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Centre for Medical Genetics, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland. Arthur P Goldberg, Affiliation/s: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Christopher Gillberg, Affiliation/s: Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, S-405 30, Sweden. John Gilbert, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Louise Gallagher, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Christine M Freitag, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Eric Fombonne, Affiliation/s: Department of Psychiatry and Institute for Development and Disability, Oregon Health and Science University, Portland, OR 97239, USA. Susan E Folstein, Affiliation/s: Division of Child and Adolescent Psychiatry, Department of Psychiatry, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Bridget Fernandez, Affiliation/s: Memorial University of Newfoundland, St John ’ s, NL, A1B 3X9, Canada. M.Daniele Fallin, Affiliation/s: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. A.Gulhan Ercan-Sencicek, Affiliation/s: Programs on Neurogenetics, Yale Uni- versity School of Medicine, New Haven, CT 06520, USA. Sean Ennis, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Centre for Medical Genetics, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland. Frederico Duque, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. Eftichia Duketis, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Richard Delorme, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, Human Genetics and Cognitive Functions Unit, Institut Pasteur, Paris, 75015, France, Centre National de la Recherche Scientifique URA 2182 Institut Pasteur, Paris, 75724, France, Department of Child and Adolescent Psychiatry, Robert Debré Hospital, Assistance Publique – Hôpitaux de Paris, Paris, 75019, France, Silvia DeRubeis, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Maretha V DeJonge, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Geraldine Dawson, Affiliation/s: Duke Center for Autism and Brain Developments, Duke University School of Medicine, Durham, NC 27705, USA, Duke Institute for Brain Sciences, Duke University School of Medicine, Durham, NC 27708, USA. Michael L Cuccaro, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Catarina T Correia, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Judith Conroy, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Temple Street Children ’ s University Hospital, Dublin, D1, Ireland. Ines C Conceição, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Andreas G Chiocchetti, Affiliation/s: Depar tment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goe the University Frankfurt, Frankfurt am Main, 60528, Germany. Patrícia BS Celestino-Soper, Affiliation/s: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indian- apolis, IN 46202, USA. Jillian Casey, Affiliation/s: Temple Street Children ’ s University Hospital, Dublin, D1, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Rita M Cantor, Affiliation/s: Department of Psychiatry, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA. Cátia Café, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal. Jonas Bybjerg-Grauholm, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Sean Brennan, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Thomas Bourgeron, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, University Paris Diderot, Sorbonne Paris Cité, Paris, 75013, France, Patrick F Bolton, Affiliation/s: Institute of Psychiatry, Kings College London, London, SE5 8AF, UK, South London and Maudsley Biomedical Research Centre for Mental Health, London, SE5 8AF, UK. Sven Bölte, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany, Department of Women ’ s and Children ’ s Health, Center of Neurodevelopmental Disorders, Karolinska Institutet, Stockholm, SE- 113 30, Sweden, Child and Adolescent Psychiatry, Center for Psychiatry Re- search, Stockholm County Council, Stockholm, SE-171 77, Sweden. Nadia Bolshakova, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Catalina Betancur, Affiliation/s: INSERM U1130, Paris, 75005, France, CNRS UMR 8246, Paris, 75005, France, Sorbonne Universités, UPMC Univ Paris 6, Neuroscience Paris Seine, Paris, 75005, France. Raphael Bernier, Affiliation/s: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA. Arthur L Beaudet, Affiliation/s: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Agatino Battaglia, Affiliation/s: Stella Maris Institute for Child and Adolescent Neuropsychiatr, Pisa, 56018, Italy. Vanessa H Bal, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Gillian Baird, Affiliation/s: Paediatric Neurodisability, King ’ s Health Partners, Kings College London, London, SE1 7EH, UK. Anthony J Bailey, Affiliation/s: Department of Psychiatry, University of Oxford and Warneford Hospital, Oxford, OX3 7JX, UK, Mental Health and Addictions Research Unit, University of British Colombia, Vancouver, BC, V5Z 4H4, Canada. Marie Bækvad-Hansen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Joel S Bader, Affiliation/s: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Elena Bacchelli, Affiliation/s: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy. Evdokia Anagnostou, Affiliation/s: Bloorview Research Institute, University of Toronto, Toronto, ON, M4G 1R8, Canada. David Amaral, Affiliation/s: The MIND Institute, School of Medicine, University of California Davis, Davis, CA 95817, USA, Department of Psychiatry, School of Medicine, University of California Davis, Davis, CA 95817, USA, Department of Behavioural Sciences, School of Medicine, University of California Davis, Davis, CA 95817, USA. Joana Almeida, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal. Anders D Børglum, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark. Joseph D Buxbaum, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Aravinda Chakravarti, Affiliation/s: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Edwin H Cook, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA. Hilary Coon, Affiliation/s: Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. Daniel H Geschwind, Affiliation/s: Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Michael Gill, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Hakon Hakonarson, Affiliation/s: The Center for Applied Genomics and Division of Human Genetics, Children ’ s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, Dept of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA. Joachim Hallmayer, Affiliation/s: Department of Psychiatry, Stanford University, Stanford, CA 94305, USA. Aarno Palotie, Affiliation/s: Sanger Institute, Hinxton, CB10 1SA, UK., Anney, Richard J. L., Ripke, Stephan, Anttila, Verneri, Grove, Jakob, Holmans, Peter, Huang, Hailiang, Klei, Lambertu, Lee, Phil H., Medland, Sarah E., Neale, Benjamin, Robinson, Elise, Weiss, Lauren A., Zwaigenbaum, Lonnie, Yu, Timothy W., Wittemeyer, Kerstin, Willsey, A. Jeremy, Wijsman, Ellen M., Werge, Thoma, Wassink, Thomas H., Waltes, Regina, Walsh, Christopher A., Wallace, Simon, Vorstman, Jacob A. S., Vieland, Veronica J., Vicente, Astrid M., Vanengeland, Herman, Tsang, Kathryn, Thompson, Ann P., Szatmari, Peter, Svantesson, Oscar, Steinberg, Stacy, Stefansson, Kari, Stefansson, Hreinn, State, Matthew W., Soorya, Latha, Silagadze, Teimuraz, Scherer, Stephen W., Schellenberg, Gerard D., Sandin, Sven, Sanders, Stephan J., Saemundsen, Evald, Rouleau, Guy A., Rogã©, Bernadette, Roeder, Kathryn, Roberts, Wendy, Reichert, Jennifer, Reichenberg, Abraham, Rehnstrã¶m, Karola, Regan, Regina, Poustka, Fritz, Poultney, Christopher S., Piven, Joseph, Pinto, Dalila, Pericak-Vance, Margaret A., Pejovic-Milovancevic, Milica, Pedersen, Marianne Giørtz, Pedersen, Carsten Bøcker, Paterson, Andrew D., Parr, Jeremy R., Pagnamenta, Alistair T., Oliveira, Guiomar, Nurnberger, John I., Nordentoft, Merete, Murtha, Michael T., Mouga, Susana, Mortensen, Preben Bo, Mors, Ole, Morrow, Eric M., Moreno-De-Luca, Daniel, Monaco, Anthony P., Minshew, Nancy, Merikangas, Alison, Mcmahon, William M., Mcgrew, Susan G., Mattheisen, Manuel, Martsenkovsky, Igor, Martin, Donna M., Mane, Shrikant M., Magnusson, Pall, Magalhaes, Tiago, Maestrini, Elena, Lowe, Jennifer K., Lord, Catherine, Levitt, Pat, Martin, Christa Lese, Ledbetter, David H., Leboyer, Marion, Lecouteur, Ann S., Ladd-Acosta, Christine, Kolevzon, Alexander, Klauck, Sabine M., Jacob, Suma, Iliadou, Bozenna, Hultman, Christina M., Hougaard, David M., Hertz-Picciotto, Irva, Hendren, Robert, Hansen, Christine Søholm, Haines, Jonathan L., Guter, Stephen J., Grice, Dorothy E., Green, Jonathan M., Green, Andrew, Goldberg, Arthur P., Gillberg, Christopher, Gilbert, John, Gallagher, Louise, Freitag, Christine M., Fombonne, Eric, Folstein, Susan E., Fernandez, Bridget, Fallin, M. Daniele, Ercan-Sencicek, A. Gulhan, Ennis, Sean, Duque, Frederico, Duketis, Eftichia, Delorme, Richard, Derubeis, Silvia, Dejonge, Maretha V., Dawson, Geraldine, Cuccaro, Michael L., Correia, Catarina T., Conroy, Judith, Conceiã§ã£o, Ines C., Chiocchetti, Andreas G., Celestino-Soper, PatrÃcia B. S., Casey, Jillian, Cantor, Rita M., Cafã©, Cã¡tia, Bybjerg-Grauholm, Jona, Brennan, Sean, Bourgeron, Thoma, Bolton, Patrick F., Bã¶lte, Sven, Bolshakova, Nadia, Betancur, Catalina, Bernier, Raphael, Beaudet, Arthur L., Battaglia, Agatino, Bal, Vanessa H., Baird, Gillian, Bailey, Anthony J., Bækvad-Hansen, Marie, Bader, Joel S., Bacchelli, Elena, Anagnostou, Evdokia, Amaral, David, Almeida, Joana, Bã¸rglum, Anders D., Buxbaum, Joseph D., Chakravarti, Aravinda, Cook, Edwin H., Coon, Hilary, Geschwind, Daniel H., Gill, Michael, Hallmayer, Joachim, Palotie, Aarno, Santangelo, Susan, Sutcliffe, James S., Arking, Dan E., Devlin, Bernie, Daly, Mark J., Hakonarson, Hakon, Génétique Humaine et Fonctions Cognitives, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Fondation FondaMental [Créteil], Génétique de l'autisme = Genetics of Autism (NPS-01), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
0301 basic medicine ,Male ,INTELLECTUAL DISABILITY ,Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium ,Autism ,Neurodevelopment ,Gene Expression ,Genome-wide association study ,[SDV.GEN] Life Sciences [q-bio]/Genetics ,lcsh:RC346-429 ,0302 clinical medicine ,2.1 Biological and endogenous factors ,Pair 10 ,Copy-number variation ,Aetiology ,Autism spectrum disorder ,Genetics ,Adaptor Proteins ,Forkhead Transcription Factors ,Serious Mental Illness ,3. Good health ,Mental Health ,Psychiatry and Mental Health ,Meta-analysis ,Female ,Biotechnology ,Human ,Autismo ,Genetic correlation ,Intellectual and Developmental Disabilities (IDD) ,Clinical Sciences ,Gene-set analysi ,Genomics ,Locus (genetics) ,FOXP1 ,Biology ,Chromosomes ,Heritability ,03 medical and health sciences ,Plasma Membrane Calcium-Transporting ATPases ,Developmental Neuroscience ,REVEALS ,mental disorders ,LINKAGE ,medicine ,Journal Article ,Humans ,Genetic Predisposition to Disease ,Meta-analysi ,GENOME-WIDE ASSOCIATION ,COMMON ,Genotyping ,Molecular Biology ,lcsh:Neurology. Diseases of the nervous system ,COPY NUMBER VARIATION ,Genetic association ,Adaptor Proteins, Signal Transducing ,Homeodomain Proteins ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,Chromosomes, Human, Pair 10 ,Research ,Human Genome ,Signal Transducing ,Neurosciences ,Membrane Proteins ,medicine.disease ,RISK LOCI ,R1 ,Brain Disorders ,Repressor Proteins ,030104 developmental biology ,Genetic Loci ,Case-Control Studies ,Perturbações do Desenvolvimento Infantil e Saúde Mental ,Schizophrenia ,Carrier Proteins ,Gene-set analysis ,MENTAL-RETARDATION ,SCAN ,030217 neurology & neurosurgery ,Transcription Factors ,Developmental Biology - Abstract
Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium - Collaborators (162): Anney RJL, Ripke S, Anttila V, Grove J, Holmans P, Huang H, Klei L, Lee PH, Medland SE, Neale B, Robinson E, Weiss LA, Zwaigenbaum L, Yu TW, Wittemeyer K, Willsey AJ, Wijsman EM, Werge T, Wassink TH, Waltes R, Walsh CA, Wallace S, Vorstman JAS, Vieland VJ, Vicente AM, vanEngeland H, Tsang K, Thompson AP, Szatmari P, Svantesson O, Steinberg S, Stefansson K, Stefansson H, State MW, Soorya L, Silagadze T, Scherer SW, Schellenberg GD, Sandin S, Sanders SJ, Saemundsen E, Rouleau GA, Rogé B, Roeder K, Roberts W, Reichert J, Reichenberg A, Rehnström K, Regan R, Poustka F, Poultney CS, Piven J, Pinto D, Pericak-Vance MA, Pejovic-Milovancevic M, Pedersen MG, Pedersen CB, Paterson AD, Parr JR, Pagnamenta AT, Oliveira G, Nurnberger JI, Nordentoft M, Murtha MT, Mouga S, Mortensen PB, Mors O, Morrow EM, Moreno-De-Luca D, Monaco AP, Minshew N, Merikangas A, McMahon WM, McGrew SG, Mattheisen M, Martsenkovsky I, Martin DM, Mane SM, Magnusson P, Magalhaes T, Maestrini E, Lowe JK, Lord C, Levitt P, Martin CL, Ledbetter DH, Leboyer M, LeCouteur AS, Ladd-Acosta C, Kolevzon A, Klauck SM, Jacob S, Iliadou B, Hultman CM, Hougaard DM, Hertz-Picciotto I, Hendren R, Hansen CS, Haines JL, Guter SJ, Grice DE, Green JM, Green A, Goldberg AP, Gillberg C, Gilbert J, Gallagher L, Freitag CM, Fombonne E, Folstein SE, Fernandez B, Fallin MD, Ercan-Sencicek AG, Ennis S, Duque F, Duketis E, Delorme R, DeRubeis S, DeJonge MV, Dawson G, Cuccaro ML, Correia CT, Conroy J, Conceição IC, Chiocchetti AG, Celestino-Soper PBS, Casey J, Cantor RM, Café C, Bybjerg-Grauholm J, Brennan S, Bourgeron T, Bolton PF, Bölte S, Bolshakova N, Betancur C, Bernier R, Beaudet AL, Battaglia A, Bal VH, Baird G, Bailey AJ, Bækvad-Hansen M, Bader JS, Bacchelli E, Anagnostou E, Amaral D, Almeida J, Børglum AD, Buxbaum JD, Chakravarti A, Cook EH, Coon H, Geschwind DH, Gill M, Hallmayer J, Palotie A, Santangelo S, Sutcliffe JS, Arking DE, Devlin B, Daly MJ. Astrid M. Vicente .- Departamento de Promoção da Saúde e Prevenção de Doenças Não Transmissíveis do INSA. PMS free full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441062/ Background: Over the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this approach is governed by the underlying effect sizes carried by the true risk variants and the corresponding statistical power to observe such effects given the study design and sample size under investigation. Previous ASD GWAS have identified genome-wide significant (GWS) risk loci; however, these studies were of only of low statistical power to identify GWS loci at the lower effect sizes (odds ratio (OR)
- Published
- 2017
- Full Text
- View/download PDF
25. The Escalation of Organizational Moral Failure in Public Discourse: A Semiotic Analysis of Nokia’s Bochum Plant Closure
- Author
-
Wessel, Lauri, Ruotsalainen, Riku, Schildt, Henri, Wickert, Christopher, European University Viadrina Frankfurt, Vrije Universiteit Amsterdam, Department of Management Studies, Aalto-yliopisto, and Aalto University
- Subjects
Media ,Economics and Econometrics ,Arts and Humanities (miscellaneous) ,Nokia ,Organizational moral failure ,Process study ,Plant closure ,Business and International Management ,Law ,General Business, Management and Accounting - Abstract
We examine the processes involved in the escalation of a plant closure from a local concern to a perceived organizational moral failure that commands national attention. Our empirical case covers the controversy over the decision of telecommunications giant Nokia to close a plant in Germany, despite having received significant state subsidies, and the relocation of production to Hungary and Romania. We conducted an inductive study that utilizes a semiotic analysis to identify how various actors framed the controversial plant closure and sought to cast it as moral failure. Our analysis uncovered two distinctive moral framings of the plant closure and revealed how key actors used evocative labels to frame these events in moral terms. These moral framings drew in additional stakeholders, generated more widespread media coverage, and turned the case into an organizational moral failure in the eyes of the national public. We contribute to the literature on organizational moral failure by theorizing its escalating process and elaborating why and how local events may become moral issues of interest to broader stakeholder groups.
- Published
- 2022
- Full Text
- View/download PDF
26. Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
- Author
-
Rui Li, Jingchen Shao, Young-June Jin, Haruya Kawase, Yu Ting Ong, Kerstin Troidl, Qi Quan, Lei Wang, Remy Bonnavion, Astrid Wietelmann, Francoise Helmbacher, Michael Potente, Johannes Graumann, Nina Wettschureck, Stefan Offermanns, Max Planck Institute for Heart and Lung Research (MPI-HLR), Max-Planck-Gesellschaft, University Hospital Frankfurt and Wolfgang Goethe University Frankfurt, Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), and Philipps Universität Marburg = Philipps University of Marburg
- Subjects
Multidisciplinary ,Cardiovascular and Metabolic Diseases ,[SDV]Life Sciences [q-bio] ,General Physics and Astronomy ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Abstract
International audience; Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however, incompletely understood. Here we report that the protocadherin FAT1 acts as a critical upstream regulator of endothelial YAP/TAZ which limits the activity of these transcriptional cofactors during developmental and tumor angiogenesis by promoting their degradation. We show that loss of endothelial FAT1 results in increased endothelial cell proliferation in vitro and in various angiogenesis models in vivo. This effect is due to perturbed YAP/TAZ protein degradation, leading to increased YAP/TAZ protein levels and expression of canonical YAP/TAZ target genes. We identify the E3 ubiquitin ligase Mind Bomb-2 (MIB2) as a FAT1-interacting protein mediating FAT1-induced YAP/TAZ ubiquitination and degradation. Loss of MIB2 expression in endothelial cells in vitro and in vivo recapitulates the effects of FAT1 depletion and causes decreased YAP/TAZ degradation and increased YAP/TAZ signaling. Our data identify a pivotal mechanism of YAP/TAZ regulation involving FAT1 and its associated E3 ligase MIB2, which is essential for YAP/ TAZ-dependent angiogenesis. The proto-cadherin Fat has originally been described in Drosophila to reduce proliferation in a variety of tissues and to regulate critical developmental processes 1,2. In the mammalian system, there is one Fat homolog, FAT4, and three Fat-like homologs, FAT1-3 1,2. FAT1 has been shown to be involved in tissue morphogenesis and vascular smooth muscle remodeling 3-8. Mutations in FAT1 have been found in various tumors where it functions as a tumor suppressor gene 9-13. FAT1 has been shown to negatively regulate YAP and TAZ in zebrafish and
- Published
- 2023
- Full Text
- View/download PDF
27. Percutaneous Isolated Hepatic Perfusion as a Treatment for Isolated Hepatic Metastases of Uveal Melanoma: Patient Outcome and Safety in a Multi-centre Study
- Author
-
Scholtz, Jan-Erik [University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology (Germany)]
- Published
- 2017
- Full Text
- View/download PDF
28. Predicting Treatment Response of Colorectal Cancer Liver Metastases to Conventional Lipiodol-Based Transarterial Chemoembolization Using Diffusion-Weighted MR Imaging: Value of Pretreatment Apparent Diffusion Coefficients (ADC) and ADC Changes Under Therapy
- Author
-
Vogl, Thomas [University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology (Germany)]
- Published
- 2017
- Full Text
- View/download PDF
29. Suicide trends in the early months of the COVID-19 pandemic: an interrupted time-series analysis of preliminary data from 21 countries
- Author
-
Vikas Arya, Kairi Kõlves, Anna Baran, Barbara Schneider, Marcos DelPozo-Banos, Vsevolod Rozanov, Christiane Schlang, Michiko Ueda, Keith Hawton, Petrana Brečić, Jane Pirkis, Sarah M. Fortune, Pablo Analuisa-Aguilar, Annette Erlangsen, Gil Zalsman, Murad M. Khan, Chengan Du, Merete Nordentoft, Sangsoo Shin, Natalia Semenova, Ann John, Giulio Castelpietra, Ella Arensman, Joseph Kanter, David Colchester, Marko Ćurković, Paul L. Plener, Guilherme Borges, Christa Rados, Jeremy S. Faust, Mark Sinyor, Louis Appleby, David Gunnell, Jason Bantjes, Rebekka Gerstner, Steve Platt, Ellenor Mittendorfer-Rutz, Thomas Niederkrotenthaler, Lakshmi Vijayakumar, Andreas Reif, Rory C. O'Connor, Kedar Marahatta, Madelyn S. Gould, Ellen Townsend, Eric D. Caine, Stuart Leske, Herwig Oberlerchner, Jeremy Dwyer, Matthew J Spittal, Olivia J. Kirtley, Shu-Sen Chang, Andrew Garrett, David Crompton, Renske Gilissen, Christine Reif-Leonhard, Roger T. Webb, Navneet Kapur, José Manoel Bertolote, Duleeka Knipe, Emma Nielsen, Manjula Weerasinghe, Michael R. Phillips, N. G. Neznanov, Daniel Radeloff, Melissa Pearson, Devin George, Eberhard A. Deisenhammer, Ping Qin, Georg Psota, Pirkis, J., John, A., Shin, S., DelPozo-Banos, M., Arya, V., Analuisa-Aguilar, P., Appleby, L., Arensman, E., Bantjes, J., Baran, A., Bertolote, J. M., Borges, G., Brecic, P., Caine, E., Castelpietra, G., Chang, S. -S., Colchester, D., Crompton, D., Curkovic, M., Deisenhammer, E. A., Du, C., Dwyer, J., Erlangsen, A., Faust, J. S., Fortune, S., Garrett, A., George, D., Gerstner, R., Gilissen, R., Gould, M., Hawton, K., Kanter, J., Kapur, N., Khan, M., Kirtley, O. J., Knipe, D., Kolves, K., Leske, S., Marahatta, K., Mittendorfer-Rutz, E., Neznanov, N., Niederkrotenthaler, T., Nielsen, E., Nordentoft, M., Oberlerchner, H., O'Connor, R. C., Pearson, M., Phillips, M. R., Platt, S., Plener, P. L., Psota, G., Qin, P., Radeloff, D., Rados, C., Reif, A., Reif-Leonhard, C., Rozanov, V., Schlang, C., Schneider, B., Semenova, N., Sinyor, M., Townsend, E., Ueda, M., Vijayakumar, L., Webb, R. T., Weerasinghe, M., Zalsman, G., Gunnell, D., Spittal, M. J., University of Melbourne, Swansea University Medical School, Western Sydney University, Ministry of Public Health, University of Manchester, University College Cork, Griffith University, Stellenbosch University, Working Group on Prevention of Suicide and Depression at Public Health Council, Blekinge Hospital, Universidade Estadual Paulista (UNESP), Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz, University of Rochester Medical Center, Outpatient and Inpatient Care Service, University of Udine, National Taiwan University, Thames Valley Local Criminal Justice Board, Medical University of Innsbruck, Yale School of Medicine, Coroners Court of Victoria, Danish Research Institute for Suicide Prevention, Johns Hopkins School of Public Health, Australian National University, Brigham and Women's Hospital Department of Emergency Medicine, University of Auckland, Magistrates Court of Tasmania (Coronial Division), Louisiana Office of Public Health, Undersecretary of Health Services, Research Department, Columbia University Medical Center/New York State Psychiatric Institute, University of Oxford, Louisiana Department of Health, Greater Manchester Mental Health NHS Foundation Trust, Aga Khan University, Center for Contextual Psychiatry, University of Bristol, University of Peradeniya, Country Office for Nepal, Karolinska Institutet, Pavlov First Saint Petersburg State Medical University, Medical University of Vienna, University of Nottingham, Mental Health Centre Copenhagen, Klinikum Klagenfurt am Wörthersee, University of Glasgow, University of Edinburgh, Shanghai Jiao Tong University School of Medicine, Columbia University, University of Ulm, Psychosocial Services in Vienna, University of Oslo, University Hospital Leipzig, Landeskrankenhaus Villach, University Hospital Frankfurt, Saint Petersburg State University, Health Authority Frankfurt am Main, LVR-Klinik Köln, Goethe-University, Bekhterev National Medical Research Center of Psychiatry and Neurology, University of Toronto, Sunnybrook Health Sciences Centre, Faculty of Political Science and Economics, Voluntary Health Services, Rajarata University of Sri Lanka, Tel Aviv University and Geha Mental Health Center, and University of Zagreb
- Subjects
Developed Countrie ,Context (language use) ,Global Health ,Interrupted Time Series Analysis ,03 medical and health sciences ,0302 clinical medicine ,Models ,Pandemic ,Global health ,Humans ,030212 general & internal medicine ,Sociology ,Biological Psychiatry ,Cause of death ,Psychiatry ,Government ,Science & Technology ,Models, Statistical ,Developed Countries ,COVID-19 ,Covid19 ,Statistical ,Mental health ,Suicide ,030227 psychiatry ,suicide ,Psychiatry and Mental health ,Life Sciences & Biomedicine ,Developed country ,Human ,Demography - Abstract
Made available in DSpace on 2022-04-28T19:40:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01 Background: The COVID-19 pandemic is having profound mental health consequences for many people. Concerns have been expressed that, at their most extreme, these consequences could manifest as increased suicide rates. We aimed to assess the early effect of the COVID-19 pandemic on suicide rates around the world. Methods: We sourced real-time suicide data from countries or areas within countries through a systematic internet search and recourse to our networks and the published literature. Between Sept 1 and Nov 1, 2020, we searched the official websites of these countries’ ministries of health, police agencies, and government-run statistics agencies or equivalents, using the translated search terms “suicide” and “cause of death”, before broadening the search in an attempt to identify data through other public sources. Data were included from a given country or area if they came from an official government source and were available at a monthly level from at least Jan 1, 2019, to July 31, 2020. Our internet searches were restricted to countries with more than 3 million residents for pragmatic reasons, but we relaxed this rule for countries identified through the literature and our networks. Areas within countries could also be included with populations of less than 3 million. We used an interrupted time-series analysis to model the trend in monthly suicides before COVID-19 (from at least Jan 1, 2019, to March 31, 2020) in each country or area within a country, comparing the expected number of suicides derived from the model with the observed number of suicides in the early months of the pandemic (from April 1 to July 31, 2020, in the primary analysis). Findings: We sourced data from 21 countries (16 high-income and five upper-middle-income countries), including whole-country data in ten countries and data for various areas in 11 countries). Rate ratios (RRs) and 95% CIs based on the observed versus expected numbers of suicides showed no evidence of a significant increase in risk of suicide since the pandemic began in any country or area. There was statistical evidence of a decrease in suicide compared with the expected number in 12 countries or areas: New South Wales, Australia (RR 0·81 [95% CI 0·72–0·91]); Alberta, Canada (0·80 [0·68–0·93]); British Columbia, Canada (0·76 [0·66–0·87]); Chile (0·85 [0·78–0·94]); Leipzig, Germany (0·49 [0·32–0·74]); Japan (0·94 [0·91–0·96]); New Zealand (0·79 [0·68–0·91]); South Korea (0·94 [0·92–0·97]); California, USA (0·90 [0·85–0·95]); Illinois (Cook County), USA (0·79 [0·67–0·93]); Texas (four counties), USA (0·82 [0·68–0·98]); and Ecuador (0·74 [0·67–0·82]). Interpretation: This is the first study to examine suicides occurring in the context of the COVID-19 pandemic in multiple countries. In high-income and upper-middle-income countries, suicide numbers have remained largely unchanged or declined in the early months of the pandemic compared with the expected levels based on the pre-pandemic period. We need to remain vigilant and be poised to respond if the situation changes as the longer-term mental health and economic effects of the pandemic unfold. Funding: None. Centre for Mental Health Melbourne School of Population and Global Health University of Melbourne Swansea University Medical School Translational Health Research Institute Western Sydney University Ministry of Public Health Department of Health Promotion National Confidential Inquiry into Suicide and Safety in Mental Health University of Manchester Centre for Mental Health and Safety and National Institute for Health Research Patient Safety Translational Research Centre University of Manchester School of Public Health National Suicide Research Foundation University College Cork Australian Institute for Suicide Research and Prevention School of Applied Psychology Griffith University Institute for Life Course Health Research Department of Global Health Stellenbosch University Working Group on Prevention of Suicide and Depression at Public Health Council Department of Psychiatry Blekinge Hospital Botucatu Medical School Universidade Estadual Paulista Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz University of Rochester Medical Center Region Friuli Venezia Giulia Central Health Directorate Outpatient and Inpatient Care Service Department of Medicine University of Udine Institute of Health Behaviors and Community Sciences College of Public Health National Taiwan University Thames Valley Local Criminal Justice Board Department of Psychiatry Psychotherapy and Psychosomatics Medical University of Innsbruck Center for Outcomes Research and Evaluation Yale School of Medicine Coroners Court of Victoria Danish Research Institute for Suicide Prevention Department of Mental Health Johns Hopkins School of Public Health Centre for Mental Health Research Australian National University Brigham and Women's Hospital Department of Emergency Medicine School of Population Health University of Auckland Magistrates Court of Tasmania (Coronial Division) Bureau of Vital Records and Statistics Louisiana Office of Public Health Ministry of Public Health Undersecretary of Health Services Research Department, 113 Suicide Prevention Departments of Psychiatry and Epidemiology Columbia University Medical Center/New York State Psychiatric Institute Centre for Suicide Research University of Oxford Louisiana Department of Health Greater Manchester Mental Health NHS Foundation Trust Department of Psychiatry Aga Khan University KU Leuven Center for Contextual Psychiatry Population Health Sciences Bristol Medical School University of Bristol South Asian Clinical Toxicology Research Collaboration Faculty of Medicine University of Peradeniya World Health Organization Country Office for Nepal Karolinska Institutet Bekhterev National Medical Research Center of Psychiatry and Neurology Pavlov First Saint Petersburg State Medical University Unit Suicide Research and Mental Health Promotion Department of Social and Preventive Medicine Center for Public Health Medical University of Vienna Department of Child and Adolescent Psychiatry Medical University of Vienna School of Psychology University of Nottingham Self-Harm Research Group School of Psychology University of Nottingham Mental Health Centre Copenhagen Department of Psychiatry and Psychotherapy Klinikum Klagenfurt am Wörthersee Suicidal Behaviour Research Lab University of Glasgow Preventing Deaths from Poisoning Research Group University of Edinburgh Usher Institute University of Edinburgh Suicide Research and Prevention Center Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Departments of Psychiatry and Epidemiology Columbia University Department of Child and Adolescent Psychiatry and Psychotherapy University of Ulm Psychosocial Services in Vienna National Centre for Suicide Research and Prevention Institute of Clinical Medicine University of Oslo Department of Child and Adolescent Psychiatry Psychotherapy and Psychosomatics University Hospital Leipzig Department of Psychiatry and Psychotherapeutic Medicine Landeskrankenhaus Villach Department of Psychiatry Psychosomatic Medicine and Psychotherapy University Hospital Frankfurt Department of Borderline Disorders and Psychotherapy Bekhterev National Medical Research Center of Psychiatry and Neurology Saint Petersburg State University Department of Psychiatry Health Authority Frankfurt am Main Department of Addictive Disorders Psychiatry and Psychotherapy LVR-Klinik Köln Department of Psychiatry Psychosomatic Medicine and Psychotherapy Goethe-University Organizational-Scientific Department Bekhterev National Medical Research Center of Psychiatry and Neurology Department of Psychiatry University of Toronto Department of Psychiatry Sunnybrook Health Sciences Centre Waseda University Faculty of Political Science and Economics Sneha—Suicide Prevention Centre Voluntary Health Services Department of Community Medicine Faculty of Medicine and Allied Sciences Rajarata University of Sri Lanka Department of Psychiatry Sackler School of Medicine Tel Aviv University and Geha Mental Health Center Division of Molecular Imaging and Neuropathology New York State Psychiatric Institute and Department of Psychiatry Columbia University National Institute of Health Research Biomedical Research Centre University Hospitals Bristol and Weston NHS Foundation Trust University of Bristol Department for Psychiatry University Psychiatric Hospital Vrapče School of Medicine University of Zagreb Botucatu Medical School Universidade Estadual Paulista
- Published
- 2021
- Full Text
- View/download PDF
30. Experimental particle formation rates spanning tropospheric sulfuric acid and ammonia abundances, ion production rates, and temperatures
- Author
-
Curtius, Joachim [Institute for Atmospheric and Environmental SciencesGoethe University Frankfurt Frankfurt am Main Germany]
- Published
- 2016
- Full Text
- View/download PDF
31. Electron density and plasma dynamics of a colliding plasma experiment
- Author
-
Jacoby, J. [Plasma Physics Group, Institute of Applied Physics, Goethe University, 60438 Frankfurt am Main (Germany)]
- Published
- 2016
- Full Text
- View/download PDF
32. SPATIAL GROWTH OF CURRENT-DRIVEN INSTABILITY IN RELATIVISTIC ROTATING JETS AND THE SEARCH FOR MAGNETIC RECONNECTION
- Author
-
Mizuno, Yosuke [Institute for Theoretical Physics, Goethe University, D-60438, Frankfurt am Main (Germany)]
- Published
- 2016
- Full Text
- View/download PDF
33. Beam transport and space charge compensation strategies (invited)
- Author
-
Wiesner, C. [IAP, Goethe University Frankfurt, Frankfurt D-60438 (Germany)]
- Published
- 2016
- Full Text
- View/download PDF
34. Design and numerical characterization of a crossover EBIS
- Author
-
Kester, Oliver [Institute of Applied Physics, Goethe University Frankfurt, Frankfurt am Main, HE, Germany and GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, HE (Germany)]
- Published
- 2015
- Full Text
- View/download PDF
35. Superconductivity and metallic behavior in Pb{sub x}C{sub y}O{sub δ} structures prepared by focused electron beam induced deposition
- Author
-
Huth, M. [Physikalisches Institut, Goethe-University, 60438 Frankfurt am Main (Germany)]
- Published
- 2014
- Full Text
- View/download PDF
36. Tabulated equation of state for supernova matter including full nuclear ensemble
- Author
-
Mishustin, I. [Frankfurt Institute for Advanced Studies, J.W. Goethe University, D-60438 Frankfurt am Main (Germany)]
- Published
- 2014
- Full Text
- View/download PDF
37. Superconductivity in the system Mo{sub x}C{sub y}Ga{sub z}O{sub δ} prepared by focused ion beam induced deposition
- Author
-
Huth, M. [Physikalisches Institut, Goethe-University, 60438 Frankfurt am Main (Germany)]
- Published
- 2014
- Full Text
- View/download PDF
38. In-situ U-Pb dating of Ries Crater lacustrine carbonates (Miocene, South-West Germany): Implications for continental carbonate chronostratigraphy
- Author
-
Damaris Montano, Giovanna Della Porta, Marta Gasparrini, Richard Albert, Axel Gerdes, IFP Energies nouvelles (IFPEN), Goethe-Universität Frankfurt am Main, Frankfurt Isotope and Element Research Center (FIERCE), Goethe-University Frankfurt, Frankfurt am Main, Germany, Sorbonne Université (SU), and Università degli Studi di Milano [Milano] (UNIMI)
- Subjects
010504 meteorology & atmospheric sciences ,U-Pb dating ,chronostratigraphy ,Geochemistry ,[SDU.STU]Sciences of the Universe [physics]/Earth Sciences ,010502 geochemistry & geophysics ,01 natural sciences ,lacustrine carbonates ,Sedimentary depositional environment ,chemistry.chemical_compound ,Impact crater ,Geochemistry and Petrology ,Earth and Planetary Sciences (miscellaneous) ,Chronostratigraphy ,0105 earth and related environmental sciences ,Miocene ,Geophysics ,Meteorite ,chemistry ,13. Climate action ,Space and Planetary Science ,Geochronology ,Facies ,laser ablation ,Carbonate ,Siliciclastic ,Geology - Abstract
International audience; The Nördlinger Ries Crater lacustrine basin (South-West Germany), formed by a meteorite impact in the Miocene (Langhian; ∼14.9 Ma), offers a well-established geological framework to understand the strengths and limitations of U-Pb LA-ICPMS (in situ Laser Ablation-Inductively Coupled Plasma Mass Spectrometry) geochronology as chronostratigraphic tool for lacustrine (and more broadly continental) carbonates. The post-impact deposits include siliciclastic basinal facies at the lake centre and carbonate facies at the lake margins, coevally deposited in a time window of >1.2 and 1.2 and
- Published
- 2021
- Full Text
- View/download PDF
39. Role of the Tropical Atlantic for the Interhemispheric Heat Transport During the Last Deglaciation
- Author
-
Karl J. F. Meier, Jacek Raddatz, Cristiano Mazur Chiessi, André Bahr, Oliver Friedrich, Ana Luiza Spadano Albuquerque, Bahr, André, 1 Institute of Earth Sciences Heidelberg University Heidelberg Germany, Chiessi, Cristiano M., 2 School of Arts, Sciences and Humanities University of São Paulo São Paulo Brazil, Albuquerque, Ana Luiza, 3 Programa de Geociências (Geoquímica) Universidade Federal Fluminense Niterói Brazil, Raddatz, Jacek, 4 Institute of Geosciences Goethe University Frankfurt Frankfurt Germany, and Friedrich, Oliver
- Subjects
551.6 ,tropical South Atlantic ,Atmospheric Science ,Brazil Current ,Paleontology ,Tropical Atlantic ,Oceanography ,foraminiferal geochemistry ,North Brazil Current ,CORRENTES OCEÂNICAS ,Heinrich Event 1 ,ddc:550 ,Deglaciation ,Bipolar seesaw ,Geology - Abstract
During the last deglaciation abrupt millennial‐scale perturbations of the Atlantic Meridional Overturning Circulation massively altered the interhemispheric heat distribution affecting, for example, continental ice volume and hydroclimate. If and how the related cross‐equatorial heat transport was controlled by the interplay between the southward‐flowing Brazil Current (BC) and northward‐flowing North Brazil Current (NBC) remains controversial. To assess the role of tropical heat transport during the last deglaciation, we obtained a high‐resolution foraminiferal Mg/Ca‐based sea surface temperature (SST) record from the BC domain at 21.5°S. The data reveal a yet undocumented warming of at least 4.6°C of the BC during Heinrich Stadial 1 at ∼16 ka indicating massive oceanic heat accumulation in the tropical South Atlantic. Simultaneously, a strongly diminished NBC prevented the release of this excess heat into the northern tropics. The observed magnitude of heat accumulation substantially exceeds numerical model simulations, stressing the need to further scrutinize atmospheric and oceanic heat transport during extreme climatic events., Plain Language Summary: The Atlantic overturning circulation underwent abrupt millennial‐scale perturbations. Such phases of sluggish oceanic circulation resulted in a substantial reduction of northward heat transport. As a consequence, substantial cooling occurred in the Northern Hemisphere and warming occurred in the Southern Hemisphere with severe effects on tropical precipitation. The distribution of heat within the western tropical Atlantic is accomplished by the southward‐flowing BC and the northward‐flowing NBC. By reconstructing SSTs for the interval between 20,000 and 10,000 yr before present, we assess the role of both currents in the interhemispheric heat transport during weak Atlantic overturning. We found that a sluggish overturning circulation resulted in anomalous southward heat transport by the BC in concert with a weak NBC, which lead to a yet undocumented warming of at least 4.6°C in the western tropical South Atlantic. This warming significantly exceeds reconstructions based on numerical simulations. This points to the need to further improve our understanding of changes in the cross‐equatorial oceanic and atmospheric heat transport in response to rapid changes in ocean circulation, in particular as a significant weakening of the Atlantic overturning circulation is predicted in the wake of anthropogenic climate change., Key Points: Brazil Current heat transport coupled to changes in strength of the Atlantic Meridional Overturning Circulation during the last deglacial. Antiphased heat transport by the Brazil and North Brazil Currents during Heinrich Event 1. Warming of western tropical South Atlantic sea surface based on foraminiferal Mg/Ca exceeds numerical model results for Heinrich Event 1., Deutsche Forschungsgemeinschaft (DFG) http://dx.doi.org/10.13039/501100001659, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) http://dx.doi.org/10.13039/501100001807, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) http://dx.doi.org/10.13039/501100002322, MCTI, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) http://dx.doi.org/10.13039/501100003593, Focus Program of the Goethe University Frankfurt, Alexander von Humboldt‐Stiftung http://dx.doi.org/10.13039/100005156
- Published
- 2021
- Full Text
- View/download PDF
40. Ibero-Panamerican Federation of Periodontics Delphi study on the trends in diagnosis and treatment of peri-implant diseases and conditions: A Latin American consensus
- Author
-
Mariano Sanz, Enrique Javer, Roberto Galindo, Marco Antonio Alarcón, Lilian Málaga-Figueroa, Vilma Umanzor, Ignacio Sanz-Sánchez, Andrea López-Pacheco, Patricia Fretes-Wood, Luis Bueno, Hugo Romanelli, Frank Schwarz, Cláudio Mendes Pannuti, Maria Elisa Galarraga-Vinueza, James R Collins, Marissa Cisneros, Lorenzo Tavelli, Andrés Felipe Vieira, Luis Peredo, Mauricio Montealegre, Alejandro Treviño, Xiomara Gimenez, Alarcón Marco Antonio, Academic Department of Clinical Stomatology, PerioImplant Research Group UPCH, Cayetano Heredia Peruvian University, Lima, Perú, Sanz-Sánchez Ignacio, ETEP (Etiology and Therapy of Periodontal and Peri-Implant Diseases) Research Group, University Complutense, Madrid, Spain, López-Pacheco Andrea, Academic Department of Clinical Stomatology, PerioImplant Research Group UPCH, Cayetano Heredia Peruvian University, Lima, Perú, Tavelli Lorenzo, Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA, Galarraga-Vinueza Maria Elisa, School of Dentistry, Universidad de Las Américas, Quito, Ecuador, Schwarz Frank, Department of Oral Surgery and Implantology, Carolinum, Johann Wolfgang Goethe-University Frankfurt, Frankfurt am Main, Germany, Romanelli Hugo, Department of Periodontics, Faculty of Health Sciences, Maimónides University, Buenos Aires, Argentina, Peredo Luis, Private Practice, Santa Cruz, Bolivia, Mendes Pannuti Claudio, Department of Periodontology, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil, Javer Enrique, Conservative Dentistry Department, Chair of Periodontology, Faculty of Dentistry, University of Chile, Santiago, Chile, Vieira Andrés Felipe, Assistant Professor of Periodontology Posgraduate Program, Pontificia Universidad Javeriana, Bogota, Colombia, Montealegre Mauricio, Posgraduate Periodontology, Pontificia Universidad Javeriana, Bogotá, Colombia, Galindo Roberto, Posgraduate Periodontology and Oral Implantology, Universidad Francisco Marroquín, Ciudad de Guatemala, Guatemala, Umanzor Vilma, Private Practice, Periodontics and Implant Dentistry, Department of Social/Prevention, School of Dentistry, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras, Treviño Alejandro, Postgraduate Studies and Research Division, Faculty of Dentistry, National Autonomous University of Mexico, UNAM, Mexico City, Mexico, Fretes-Wood Patricia, Department of Implantology, Universidad del Pacífico, Asunción, Paraguay 16, Cisneros Marissa, Department of Periodontology, School of Dentistry, Universidad Interamericana de Panama, Panama City, Panama, Collins James R., Department of Periodontology, School of Dentistry, Pontificia Universidad Católica Madre y Maestra (PUCMM), Santo Domingo, Dominican Republic, Bueno Rossy Luis Alexandro, Periodontics Department, School of Dentistry, Universidad de la República, Montevideo, Uruguay, Gimenéz Xiomara, PerioImplant Research Group UCV, University Central of Venezuelan, Caracas, Venezuela, Málaga-Figueroa Lilian, Academic Department of Clinical Stomatology, PerioImplant Research Group UPCH, Cayetano Heredia Peruvian University, Lima, Perú, and Sanz Mariano, ETEP (Etiology and Therapy of Periodontal and Peri-Implant Diseases) Research Group, University Complutense, Madrid, Spain
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Latin Americans ,Consensus ,Delphi Technique ,diagnosis ,Steering committee ,Delphi method ,Odontología ,03 medical and health sciences ,0302 clinical medicine ,Delphi technique ,dental implants ,medicine ,Humans ,Dental Implants ,Implantes dentales ,PERIIMPLANTITIS ,Implant dentistry ,business.industry ,Social diversity ,030206 dentistry ,Periodontology ,Peri-Implantitis ,030104 developmental biology ,Latin America ,consensus ,Family medicine ,IMPLANTES DENTALES ,Periodontics ,ESTUDIO DIAGNOSTICO ,business ,peri-implantitis - Abstract
Background: The social diversity, heterogeneous culture, and inherent economic inequality factors in Latin America (LA) justify conducting a comprehensive analysis on the current status and future trends of peri-implant diseases and conditions. Thus, the aim of this Delphi study was to predict the future trends in the diagnosis and treatment of peri-implant diseases and conditions in LA countries for the year 2030. Methods: A Latin American steering committee and group of experts in implant dentistry validated a questionnaire including 64 questions divided into eight sections. The questionnaire was run twice with an interval of 45 days, with the results from the first round made available to all the participants in the second round. The results were expressed in percentages and data was analyzed describing the consensus level reached in each question. Results: A total of 221 experts were invited to participate in the study and a total 214 (96.8%) completed the two rounds. Moderate (65%-85%) to high consensus (≥85%) was reached in 51 questions (79.69%), except in the questions dealing with “prevalence”, where no consensus was reached. High and moderate consensus was attained for all the questions in three fields (risk factors and indicators, diagnosis and treatment of peri-implant conditions and deficiencies, and prevention and maintenance). Conclusions: The present study has provided relevant and useful information on the predictions in the diagnosis and treatment of peri-implant diseases with a high level of consensus among experts. Nevertheless, there is still a lack of agreement in certain domains.
- Published
- 2021
41. Improvement of Stent Retriever Design and Efficacy of Mechanical Thrombectomy in a Flow Model
- Author
-
Berkefeld, Joachim [Institute of Neuroradiology, University of Frankfurt am Main (Germany)]
- Published
- 2013
- Full Text
- View/download PDF
42. Development of a Nomarski-type multi-frame interferometer as a time and space resolving diagnostics for the free electron density of laser-generated plasma
- Author
-
Tauschwitz, An [ITP, University of Frankfurt am Main (Germany)]
- Published
- 2012
- Full Text
- View/download PDF
43. Cold quark matter in astrophysics of compact stars
- Author
-
Sedrakian, Armen [Institute for Theoretical Physics, J. W. Goethe-University, D-60438 Frankfurt am Main (Germany)]
- Published
- 2010
- Full Text
- View/download PDF
44. Nambu-Jona-Lasinio model description of weakly interacting Bose condensate and BEC-BCS crossover in dense QCD-like theories
- Author
-
Lianyi, He [Frankfurt Institute for Advanced Studies and Institute for Theoretical Physics, J. W. Goethe University, 60438 Frankfurt am Main (Germany)]
- Published
- 2010
- Full Text
- View/download PDF
45. ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma
- Author
-
Gutwein, Paul [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany)]
- Published
- 2010
- Full Text
- View/download PDF
46. Recanalization Results After Intracranial Stenting of Atherosclerotic Stenoses
- Author
-
Mesnil de Rochemont, Richard [University of Frankfurt, Institute of Neuroradiology (Germany)]
- Published
- 2010
- Full Text
- View/download PDF
47. Phase diagram of chiral quark matter: Color and electrically neutral Fulde-Ferrell phase
- Author
-
Sedrakian, Armen [Institute for Theoretical Physics, J. W. Goethe-University, D-60438 Frankfurt am Main (Germany)]
- Published
- 2010
- Full Text
- View/download PDF
48. Radiation-Induced Survivin Nuclear Accumulation is Linked to DNA Damage Repair
- Author
-
Roedel, Franz [Departments of Radiation Therapy and Oncology, University of Frankfurt/Main, 60590 Frankfurt (Germany)]
- Published
- 2010
- Full Text
- View/download PDF
49. Response functions of cold neutron matter: Density fluctuations
- Author
-
Keller, Jochen [Institute for Theoretical Physics, J. W. Goethe University, D-60438 Frankfurt-am-Main (Germany)]
- Published
- 2010
- Full Text
- View/download PDF
50. Thermal nature of charmonium transverse momentum spectra from Au-Au collisions at the highest energies available at the BNL Relativistic Heavy Ion Collider (RHIC)
- Author
-
Braun-Munzinger, P [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt, ExtreMe Matter Institute EMMI, GSI, D-64291 Darmstadt, Technical University Darmstadt, D-64289 Darmstadt, and Frankfurt Institute for Advanced Studies, J. W. Goethe University, D-60438 Frankfurt (Germany)]
- Published
- 2010
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.