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5,303 results on '"University of Salamanca"'

1. Predictive Model to Calculate the Risk of RBC Transfusion in Elective Brain Tumours Resections (TScoreBTR) (TScoreBTR)

Author

Hospital Clinic of Barcelona, University of Salamanca, Hospital de Leon, Parc Taulí Hospital Universitari, Hospital de Cruces, Hospital del Mar, Hospital Universitario Marqués de Valdecilla, Hospital Universitario Central de Asturias, Hospital Son Espases, Hospital Clínico Universitario Virgen de la Arrixaca, Hospital General Universitario de Valencia, Hospital Universitari de Bellvitge, and Hospital Miguel Servet

Published
2024

3. EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction (CARPEDIEM Trial)

Author

Hospital Mutua de Terrassa, Hospital Clínico Universitario de Valencia, Hospital General Universitario de Alicante, Hospital General Universitario de Castellón, Complejo Hospitalario Universitario de Santiago, University Hospital Virgen de las Nieves, Complejo Hospitalario de Navarra, Hospital de Sant Pau, University of Salamanca, and Joan B Gornals, PhD and Head of Interventional Endoscopy Unit

Published
2024

4. EUS-Gallbladder vs CDS as First Line in MBDO- Palliative (CARPEGIEM Trial) (CARPEGIEM)

Author

Hospital Clínico Universitario de Valencia, Hospital General Universitario de Alicante, Hospital Mutua de Terrassa, Hospital Universitario Ramon y Cajal, Hospital General Universitario de Castellón, Complejo Hospitalario de Navarra, University Hospital Virgen de las Nieves, Hospital de Sant Pau, University of Salamanca, Complejo Hospitalario Universitario de Santiago, Complejo Hospitalario Universitario de Vigo, and Joan B Gornals, PhD and Head of Interventional Endoscopy Unit

Published
2024

5. Safety and Efficacy of Allogeneic Adipose Tissue Mesenchymal Stem Cells in Diabetic Patients With Critical Limb Ischemia

Author

Clinica Universidad de Navarra, Universidad de Navarra, Hospital Universitario La Paz, Gregorio Marañón Hospital, Hospital Clínico Universitario de Valladolid, Hospital Universitario Virgen de la Arrixaca, University of Salamanca, Hospital General Universitario de Alicante, Hospital Universitario La Fe, and Hospital Victoria Eugenia Cruz Roja Española

Published
2024

9. EUS-guided Choledochoduodenostomy vs ERCP as First Line in Malignant Distal Obstruction in Resectable Disease (CARPEDIEM-1 Trial)

Author

Hospital Mutua de Terrassa, Hospital Clínico Universitario de Valencia, Hospital General Universitario de Alicante, Hospital Universitario Ramon y Cajal, Hospital General Universitario de Castellón, Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Santiago, University Hospital Virgen de las Nieves, Complejo Hospitalario de Navarra, Hospital de Sant Pau, University of Salamanca, and Joan B Gornals, PhD and Head of Interventional Endoscopy Unit

Published
2024

10. EUS-guided CDS vs ERCP as First Line in Malignant Distal Obstruction in Borderline Disease (CARPEDIEM-2 Trial)

Author

Hospital Mutua de Terrassa, Hospital Clínico Universitario de Valencia, Hospital General Universitario de Alicante, Hospital Universitario Ramon y Cajal, Hospital General Universitario de Castellón, Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Santiago, University Hospital Virgen de las Nieves, Complejo Hospitalario de Navarra, Hospital de Sant Pau, University of Salamanca, and Joan B Gornals, PhD and Head of Interventional Endoscopy Unit

Published
2024

11. INOCA Spanish National Registry (ESP-INOCA)

Author

Hospital San Carlos, Madrid, Fundación de Investigación Biomédica - Hospital Universitario de La Princesa, Hospital Universitario Virgen de la Arrixaca, University Hospital Gregorio Marañón, Hospital Clínico Universitario de Valladolid, Hospital Universitario Puerta del Mar, Hospital Universitari de Bellvitge, Hospital Universitario La Fe, Hospital Clínico Universitario de Valencia, Hospital Universitario La Paz, Hospital General Universitario de Alicante, Complejo Hospitalario Universitario de Huelva, Hospital General Universitario de Castellón, Hospital de Manises, Hospital Clinic of Barcelona, Hospital Miguel Servet, Hospital Clínico Universitario Lozano Blesa, Hospital Universitario Donostia, Hospital General Universitario Elche, Hospital Universitario Virgen del Rocio, Hospital de la Ribera, Hospital de la Santa creu i Sant Pau - Barcelona, Hospital Virgen de la Salud, Hospital Universitario San Juan de Alicante, Hospital Universitario de Torrevieja, University Hospital of the Nuestra Señora de Candelaria, Hospital de Basurto, Hospital Universitario Ramon y Cajal, Hospital Universitario Fundación Jiménez Díaz, Puerta de Hierro University Hospital, Hospital Universitario 12 de Octubre, University of Salamanca, Hospital Universitario Marqués de Valdecilla, Hospital Clinico Universitario de Santiago, Complexo Hospitalario Universitario de A Coruña, and Eva Rumiz González, Principal Investigator

Published
2024

13. Immune Checkpoint Inhibitors Nephrotoxicity

Author

Instituto de Investigación Biomédica de Salamanca, Hospital Clínico Universitario de Valladolid, University of Salamanca, and R. Laura Vicente Vicente, University professor

Published
2023

18. BAttLe Against COVID-19 Using MesenchYmal Stromal Cells

Author

Instituto de Investigación Sanitaria y Biomédica de Alicante, Hospital General Universitario Gregorio Marañon, Clinica Universidad de Navarra, Universidad de Navarra, University of Salamanca, Hospital General Universitario de Alicante, and Hospital Clínico Universitario Virgen de la Arrixaca

Published
2021

20. Gastrointestinal Endoscopy in Patients With Prothrombotic Conditions: THE ENDOHEM REGISTRY

Author

University of Salamanca, Hospital Universitario Central de Asturias, Hospital Universitario 12 de Octubre, Puerta de Hierro University Hospital, Hospital del Mar, Hospital de Viladecans, Hospital Clinic of Barcelona, Hospital de Avilés, Hospital General de Villalba, Hospital General de Granollers, Hospital Sant Pau, and Enrique Rodríguez de Santiago, Principal Investigator. MSc. Gastroenterologist

Published
2020

22. Hemospray in Gastrointestinal Bleeding: A Real-life Multicenter Cohort

Author

University of Salamanca, Hospital del Mar, Puerta de Hierro University Hospital, Complejo Hospitalario de Navarra, Hospital de Henares, Fundación de Investigación Biomédica - Hospital Universitario de La Princesa, Quirón Madrid University Hospital, Hospital de Cruces, Hospital General Universitario Gregorio Marañon, Hospital Universitario Central de Asturias, Hospital Universitario de Cabuenes, Hospital Universitario Doctor Peset, Hospital del Rio Hortega, Hospital Universitario Madrid Sanchinarro, Hospital de Aviles, Hospital IMQ Zorrozaurre, and Enrique Rodríguez de Santiago, M.D Gastroenterologist

Published
2019

23. Safety and Efficacy Evaluation of Intracoronary Infusion of Allogeneic Human Cardiac Stem Cells in Patients With AMI (CAREMI)

Author

European Commission, Universitaire Ziekenhuizen KU Leuven, Saint-Louis Hospital, Paris, France, Hospital General Universitario Gregorio Marañon, Complejo Hospitalario de Navarra, Hospital Clínico Universitario de Valladolid, Hospital Donostia, Hospital Clínico Universitario de Valencia, University of Salamanca, and Hospital Universitario Virgen de la Victoria

Published
2017

27. Bortezomib, Dexamethasone, and Rituximab in Untreated Waldenstroms Macroglobulinemia (BDR-WM)

Author

University of Athens, University of Roma La Sapienza, Niguarda Hospital, University of Turin, Italy, University of Salamanca, Hospital Clinic of Barcelona, Hotel Dieu Hospital, Erasmus Medical Center, University Hospital, Toulouse, Fondazione IRCCS Policlinico San Matteo di Pavia, Laikο General Hospital, Athens, Klinikum der Universitaet Muenchen, Grosshadern, Aalborg University Hospital, Centre Hospitalier de Lens, Universitaire Ziekenhuizen KU Leuven, Theagenio Cancer Hospital, University of Wuerzburg, Skane University Hospital, Vastra Gotaland Region, and Professor Hans Erik Johnsen, Sponsor Office Director, Professor

Published
2015

29. Dynamic, ecological, accessible and 3D Virtual Worlds-based Libraries using OpenSim and Sloodle along with mobile location and NFC for checking in

Author

Ruben Gonzalez Crespo, Pontifical University of Salamanca, Roberto Ferro Escobar, and Nicolás Torres

Subjects
3D Virtual Library, OpenSim, Sloodle, NFC, GPS, Grid, Technology
Abstract

This paper proposes the implementation of a 3D virtual library, using open platforms such as OpenSimulator and Sloodle, applied to the integration of virtual learning environments. It also proposes their application to the creation of open libraries to share and disseminate the new dynamic nature of knowledge, in the understanding that 3D virtual worlds may contribute to the future of libraries as part of green initiatives to achieve an ecologic and sustainable planet.

Published
2012

30. Determining the banking solvency risk in times of COVID-19 through Gram-Charlier expansions

Author

Instituto Tecnológico Metropolitano - ITM, Universidad EAFIT, University of Salamanca, Rendón, Juan F., Cortés, Lina M., Perote, Javier, Instituto Tecnológico Metropolitano - ITM, Universidad EAFIT, University of Salamanca, Rendón, Juan F., Cortés, Lina M., and Perote, Javier

Abstract

This paper proposes risk measures for bank solvency by accurately measuring the solvency risk components. These measures consider the minimum regulatory solvency levels and banks’ risk appetite level and risk profile. For this purpose, we used semi-nonparametric statistics to model stylized facts of the risk distribution, particularly the high-order moments of the Solvency Decline Rate, the Tier Decline Rate, and the Portfolio Growth Rate variables. Additionally, these risk measures can be used to measure the risk of regulatory intervention and to define policies that establish the minimum solvency levels required by banking regulators by estimating the Quantile Risk Metrics. As a case study, we collected data on the solvency indicators of the Colombian banking system, which adapts to the standards established by the Basel Committee. According to the results, the liquidity injection measures implemented in response to the needs generated by the COVID-19 pandemic led to an increase in the levels of the risk portfolio in the Colombian banking system, which exceeded the 99th percentile of the probability distribution of monthly portfolio value changes.

Published
2021

32. Micropolitics and meritocracy: improbable bedfellows?

Author

University of Salamanca, ERC, Montes, Estrella, O'Connor, Pat, University of Salamanca, ERC, Montes, Estrella, and O'Connor, Pat

Abstract

peer-reviewed, Universities present themselves as meritocratic organizations; however, there is evidence that such claims are ‘rationalised myths’. This article is concerned with the perceived effect of micropolitics on academic careers in two case study universities: a collegial Spanish and a managerial Irish one. The data are drawn from 86 semi-structured interviews with academics (43 from each context). The focus is on two aspects of micropolitics: those related to career experiences, particularly networks; and those related to the evaluation of candidates, particularly double standards. Research results show that informal social networks are perceived to facilitate career progression; and these are referred to in particular by the Spanish male respondents. Double standards in evaluation are used to favour specific candidates: local ones in the Spanish case, men in the Irish case. Men in the Spanish context refer more openly than their Irish counterparts to these double standards, arguably reflecting the strength of discourses other than merit in that context. The results suggest that the informal structure influences the formal structure regardless of the governance model, raising fundamental questions about the nature of universities and the limitations of structural changes., ACCEPTED, peer-reviewed

Published
2018

33. VaR performance during the subprime and sovereign debt crises: An application to emerging markets

Author

Economía y Finanzas, Finanzas, aculty of Economics and Business, Department of Business, University of Salamanca, Spain, School of Economics and Finance, Department of Finance, EAFIT University, Colombia, Faculty of Economics and Business, Department of Economics, University of Salamanca, Spain, Grupo de Investigación Finanzas y Banca, B. Del Brio, Esther, Mora-Valencia, Andrés, Perote, Javier, Economía y Finanzas, Finanzas, aculty of Economics and Business, Department of Business, University of Salamanca, Spain, School of Economics and Finance, Department of Finance, EAFIT University, Colombia, Faculty of Economics and Business, Department of Economics, University of Salamanca, Spain, Grupo de Investigación Finanzas y Banca, B. Del Brio, Esther, Mora-Valencia, Andrés, and Perote, Javier

Abstract

Highly volatile scenarios, such as those provoked by the recent subprime and sovereign debt crises, have questioned the accuracy of current risk forecasting methods. This paper adds fuel to this debate by comparing the performance of alternative specifications for modeling the returns filtered by an ARMA-GARCH: Parametric distributions (Student's t and skewed-t), the extreme value theory (EVT), semi-nonparametric methods based on the Gram–Charlier (GC) expansion and the normal (benchmark). We implement backtesting techniques for the pre-crisis and crisis periods for stock index returns and a hedge fund of emerging markets. Our results show that the Student's t fails to forecast VaR during the crisis, while the EVT and GC accurately capture market risk, the latter representing important savings in terms of efficient regulatory capital provisions.

Published
2014
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34. Semi-nonparametric VaR forecasts for hedge funds during the recent crisis

Author

Economía y Finanzas, Finanzas, Faculty of Economics and Business, Department of Business, University of Salamanca, Spain, School of Economics and Finance, Department of Finance, EAFIT University, Colombia, Faculty of Economics and Business, Department of Economics, University of Salamanca, Spain, Grupo de Investigación Finanzas y Banca, B. Del Brio, Esther, Mora-Valencia, Andrés, Perote, Javier, Economía y Finanzas, Finanzas, Faculty of Economics and Business, Department of Business, University of Salamanca, Spain, School of Economics and Finance, Department of Finance, EAFIT University, Colombia, Faculty of Economics and Business, Department of Economics, University of Salamanca, Spain, Grupo de Investigación Finanzas y Banca, B. Del Brio, Esther, Mora-Valencia, Andrés, and Perote, Javier

Abstract

The need to provide accurate value-at-risk (VaR) forecasting measures has triggered an important literature in econophysics. Although these accurate VaR models and methodologies are particularly demanded for hedge fund managers, there exist few articles specifically devoted to implement new techniques in hedge fund returns VaR forecasting. This article advances in these issues by comparing the performance of risk measures based on parametric distributions (the normal, Student’s t and skewed-t), semi-nonparametric (SNP) methodologies based on Gram–Charlier (GC) series and the extreme value theory (EVT) approach. Our results show that normal-, Student’s t- and Skewed t- based methodologies fail to forecast hedge fund VaR, whilst SNP and EVT approaches accurately success on it. We extend these results to the multivariate framework by providing an explicit formula for the GC copula and its density that encompasses the Gaussian copula and accounts for non-linear dependences. We show that the VaR obtained by the meta GC accurately captures portfolio risk and outperforms regulatory VaR estimates obtained through the meta Gaussian and Student’s tdistributions.

Published
2014
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35. In memory of Federico Uruburu (1934-2003)

Author

Julio R. Villanueva; Vice-president, Scientific Council, Fundación Ramón Areces, Madrid, Spain; and Institute of Biochemical Microbiology, CSIC-University of Salamanca, Salamanca, Spain, Isabel García-Acha; Institute of Biochemical Microbiology, CSIC-University of Salamanca, Salamanca, Spain, Julio R. Villanueva; Vice-president, Scientific Council, Fundación Ramón Areces, Madrid, Spain; and Institute of Biochemical Microbiology, CSIC-University of Salamanca, Salamanca, Spain, and Isabel García-Acha; Institute of Biochemical Microbiology, CSIC-University of Salamanca, Salamanca, Spain

Published
2010

37. Frequency and Associated Factors of Suicidal Ideation in Patients with Chronic Obstructive Pulmonary Disease

Author

Carlos Roncero, Joselín Pérez, Jesús Molina, José Antonio Quintano, Ana Isabel Campuzano, Javier Pérez, Marc Miravitlles, Institut Català de la Salut, [Roncero C, Pérez J] Psychiatric Service, University of Salamanca Health Care Complex, 37007 Salamanca, Spain. Institute of Biomedicine of Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain. [Pérez J] Medical Department, Grupo Ferrer, 08029 Barcelona, Spain. [Molina J] Centro de Salud Francia, Dirección Asistencial Oeste, 28993 Madrid, Spain. [Quintano JA] Centro de Salud Lucena I, Lucena, 14900 Córdoba, Spain. [Campuzano AI] Medical Department, Grupo Ferrer, 08029 Barcelona, Spain. [Miravitlles M] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Suïcidi - Factors de risc, Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Self-Injurious Behavior::Suicide::Suicidal Ideation [PSYCHIATRY AND PSYCHOLOGY], Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive [DISEASES], conducta y mecanismos de la conducta::conducta::síntomas conductuales::conducta autolesiva::suicidio::ideación suicida [PSIQUIATRÍA Y PSICOLOGÍA], Pulmons - Malalties obstructives, Beck Depression Inventory, depression, COPD, suicide, General Medicine, enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica [ENFERMEDADES]
Abstract

COPD; Depression; Suicide EPOC; Depresión; Suicidio MPOC; Depressió; Suïcidi We aimed to examine the prevalence of suicidal ideation in patients with chronic obstructive pulmonary disease (COPD) and the association between demographic and clinical variables and the occurrence of suicidal thoughts. This was a cross-sectional study. Sociodemographic and clinical data were recorded, and questionnaires were used to assess depressive symptoms (Beck Depression Inventory), comorbidities (Charlson Index), cognitive performance (Mini Mental State Examination), and quality of life (EuroQoL-5 dimensions and CAT). Specific questions about suicide-related behavior were included. Multivariate logistic regression analysis identified the significant factors associated with previous suicidal ideation and suicide attempts. The analysis included 1190 subjects. The prevalence of suicidal ideation and suicide attempts were 12.1% and 2.5%, respectively. Severely depressed patients had the highest prevalence of suicide-related behavior. The adjusted logistic model identified factors significantly associated with suicidal ideation: sex (odds ratio (OR) for women vs. men = 2.722 (95% confidence interval (CI) = 1.771–4.183)), depression score (OR = 1.163 (95% IC = 1.127–1.200)), and Charlson Index (OR 1.228 (95% IC 1.082–1.394)). Suicidal ideation is common in COPD patients, especially in women. While addressing suicidal ideation and suicide prevention, clinicians should first consider the management of depressive symptomatology and the improvement of coping strategies. The DeprEPOC study was funded by an unrestricted grant from Grupo Ferrer (Barcelona, Spain).

Published
2022
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38. A Feasibility Study of Patients with Major Depression and Substance Use Disorders: Vortioxetine as Maintenance Treatment

Author

Ignacio Basurte-Villamor, Pablo Vega, Carlos Roncero, José Martínez-Raga, Lara Grau-López, Lourdes Aguilar, Marta Torrens, Nestor Szerman, Institut Català de la Salut, [Basurte-Villamor I] Department of Psychiatry and Behavioral Health, Clínica López Ibor, Madrid, Spain. [Vega P] Institute for Addictions, Madrid Salud, Madrid City Council, Madrid, Spain. [Roncero C, Aguilar L] Department of Psychiatry, University of Salamanca Healthcare Complex, Salamanca, Spain. Institute of Biomedicine of Salamanca, University of Salamanca, Salamanca, Spain. Psychiatric Unit, School of Medicine, University of Salamanca, Salamanca, Spain. [Martínez-Raga J] Department of Psychiatry and Clinical Psychology, University Hospital Dr. Peset and University of Valencia, Valencia, Spain. [Grau-López L] Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health, CIBERSAM, Barcelona, Spain. Grup de Recerca de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Psiquiatria i Medicina Forense, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Torrens M] Institute of Neuropsychiatry & Addictions-Hospital del Mar, Barcelona IMIM, Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Szerman N] WADD WPA Section Dual Disorders, Mental Health and Psychiatric Institute, Gregorio Marañon University Hospital, Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Real-world evidence, Neuropsychiatric Disease and Treatment, Mental Disorders::Mood Disorders::Depressive Disorder::Depressive Disorder, Major [PSYCHIATRY AND PSYCHOLOGY], Mental Disorders::Substance-Related Disorders [PSYCHIATRY AND PSYCHOLOGY], Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Psychotropic Drugs::Antidepressive Agents [CHEMICALS AND DRUGS], Otros calificadores::/uso terapéutico [Otros calificadores], trastornos mentales::trastornos relacionados con sustancias [PSIQUIATRÍA Y PSICOLOGÍA], Malalties mentals - Tractament, Depressió psíquica - Tractament, Major depressive disorder, acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::fármacos psicotrópicos::antidepresivos [COMPUESTOS QUÍMICOS Y DROGAS], Substance use disorder, Abús de substàncies, Major dual depressive disorder, Vortioxetine, Other subheadings::/therapeutic use [Other subheadings], trastornos mentales::trastornos del humor::trastorno depresivo::trastorno depresivo mayor [PSIQUIATRÍA Y PSICOLOGÍA], Dual disorder, Antidepressius - Ús terapèutic
Abstract

Ignacio Basurte-Villamor,1 Pablo Vega,2 Carlos Roncero,3– 5 José Martínez-Raga,6 Lara Grau-López,7– 10 Lourdes Aguilar,3– 5 Marta Torrens,11 Nestor Szerman12 1Department of Psychiatry and Behavioral Health, Clínica López Ibor, Madrid, Spain; 2Institute for Addictions, Madrid Salud, Madrid City Council, Madrid, Spain; 3Department of Psychiatry, University of Salamanca Healthcare Complex, Salamanca, Spain; 4Institute of Biomedicine of Salamanca, University of Salamanca, Salamanca, Spain; 5Psychiatric Unit, School of Medicine, University of Salamanca, Salamanca, Spain; 6Department of Psychiatry and Clinical Psychology, University Hospital Dr. Peset and University of Valencia, Valencia, Spain; 7Department of Psychiatry, Hospital Universitari Vall d’Hebron, Barcelona, Spain; 8Biomedical Network Research Centre on Mental Health, CIBERSAM, Barcelona, Spain; 9Group of Psychiatry, Mental Health and Addiction, Vall d’Hebron Research Institute, Barcelona, Spain; 10Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain; 11Institute of Neuropsychiatry & Addictions-Hospital del Mar, Barcelona IMIM, Hospital del Mar Medical Research Institute, Barcelona University Autònoma, Barcelona, Spain; 12WADD WPA Section Dual Disorders, Mental Health and Psychiatric Institute, Gregorio Marañon University Hospital, Madrid, SpainCorrespondence: Nestor Szerman, WADD WPA Section Dual Disorders, Mental Health and Psychiatric Institute, Gregorio Marañon University Hospital, C/ Lope de Rueda 43, Madrid, 28009, Spain, Tel +34 914008690, Fax +34 915739932, Email nszermanb@gmail.comBackground: Limited studies have evaluated the effectiveness of vortioxetine in real-world settings, and none of them has involved patients with dual depression (major depressive disorder [MDD] and substance use disorder [SUD]). The objective of the study was to describe the effectiveness of vortioxetine in clinical practice and determine its effect on affective symptoms, cognitive function, quality of life, and substance use in patients with MDD and SUD.Methods: Post-authorization, retrospective, multicenter, descriptive, and observational study in 80 patients with MDD and SUD receiving a maintenance treatment with vortioxetine for six months between January 2017 and April 2021.Results: Compared with baseline, scores significantly decreased after 3 and 6 months of treatment in the Montgomery-Åsberg Depression Rating Scale total (from 28.9 to 17.7 and 12.0), and global functional impairment of the Sheehan Disability Inventory (from 26.3 to 19.1 and 16.7). The number of correct answers in the symbol digit modalities test significantly improved during vortioxetine treatment (from 40.4 to 43.8 and 48.4). Regarding the clinical global impression scale, the score for disease severity significantly decreased from 3.8 to 3.0 and 2.4. Compared with baseline, there was a significant reduction in consumption of practically all substances, especially of alcohol, cannabis, and cocaine.Conclusion: Vortioxetine was effective in clinical practice for alleviating depressive symptoms and functional impairment, and in improving cognitive and executive functions and disease severity in patients with MDD and SUD. Moreover, the treatment with vortioxetine favored a reduction in substance use and the severity of the SUDs.Keywords: vortioxetine, major depressive disorder, substance use disorder, dual disorder, major dual depressive disorder, real-world evidence

Published
2022

39. Impact of Liver Inflammation on Bile Acid Side Chain Shortening and Amidation

Author

Marta Alonso-Peña, Ricardo Espinosa-Escudero, Heike M. Hermanns, Oscar Briz, Jose M. Herranz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Javier Juamperez, Matias Avila, Josepmaria Argemi, Ramon Bataller, Javier Crespo, Maria J. Monte, Andreas Geier, Elisa Herraez, Jose J. G. Marin, Institut Català de la Salut, [Alonso-Peña M] Experimental Hepatology and Drug Targeting (HEVEPHARM), Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain. Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqués de Valdecilla University Hospital, Santander, Spain. Division of Hepatology, Würzburg University Hospital, Medical Clinic II, Würzburg, Germany. [Espinosa-Escudero R] Experimental Hepatology and Drug Targeting (HEVEPHARM), Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain. [Hermanns HM] Division of Hepatology, Würzburg University Hospital, Medical Clinic II, Würzburg, Germany. [Briz O] Experimental Hepatology and Drug Targeting (HEVEPHARM), Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Institute of Health, Madrid, Spain. [Herranz JM] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Institute of Health, Madrid, Spain. Hepatology Program, Liver Unit, Instituto de Investigación de Navarra (IdisNA), Clínica Universidad de Navarra and Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain. [Garcia-Ruiz C] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Institute of Health, Madrid, Spain. Institute of Biomedical Research of Barcelona (IIBB), Centro Superior de Investigaciones Científicas (CSIC), Barcelona, Spain. Center for ALPD, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. [Juamperez J] Unitat de Gastroenterologia, Hepatologia, Suport Nutricional i Trasplantaments Hepàtics Pediàtrics, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Instituto de Salud Carlos III, European Commission, Junta de Castilla y León, Fundació La Marató de TV3, Asociación Española Contra el Cáncer, Interdisciplinary Center for Clinical Research (Germany), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, European Cooperation in Science and Technology, and Fundación Echebano

Subjects
Inflammation, Àcids biliars, NASH, Fetge - Malalties, ASH, Bile acid, Oncostatin M, Polycyclic Compounds::Fused-Ring Compounds::Steroids::Bile Acids and Salts [CHEMICALS AND DRUGS], Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation [DISEASES], General Medicine, BAAT, Inflamació, compuestos policíclicos::compuestos con anillos de fusión::esteroides::ácidos y sales biliares [COMPUESTOS QUÍMICOS Y DROGAS], enfermedades del sistema digestivo::enfermedades hepáticas [ENFERMEDADES], Digestive System Diseases::Liver Diseases [DISEASES], inflammation, NAFL, afecciones patológicas, signos y síntomas::procesos patológicos::inflamación [ENFERMEDADES], ACOX2, bile acid, oncostatin M
Abstract

Bile acid (BA) synthesis from cholesterol by hepatocytes is inhibited by inflammatory cytokines. Whether liver inflammation also affects BA side chain shortening and conjugation was investigated. In human liver cell lines (IHH, HepG2, and HepaRG), agonists of nuclear receptors including the farnesoid X receptor (FXR), liver X receptor (LXR), and peroxisome proliferator-activated receptors (PPARs) did not affect the expression of BA-related peroxisomal enzymes. In contrast, hepatocyte nuclear factor 4¿ (HNF4¿) inhibition down-regulated acyl-CoA oxidase 2 (ACOX2). ACOX2 was repressed by fibroblast growth factor 19 (FGF19), which was prevented by extracellular signal-regulated kinase (ERK) pathway inhibition. These changes were paralleled by altered BA synthesis (HPLC-MS/MS). Cytokines able to down-regulate cholesterol-7¿-hydroxylase (CYP7A1) had little effect on peroxisomal enzymes involved in BA synthesis except for ACOX2 and bile acid-CoA:amino acid N-acyltransferase (BAAT), which were down-regulated, mainly by oncostatin M (OSM). This effect was prevented by Janus kinase (JAK) inhibition, which restored BA side chain shortening and conjugation. The binding of OSM to the extracellular matrix accounted for a persistent effect after culture medium replacement. In silico analysis of four databases (n = 201) and a validation cohort (n = 90) revealed an inverse relationship between liver inflammation and ACOX2/BAAT expression which was associated with changes in HNF4¿ levels. In conclusion, BA side chain shortening and conjugation are inhibited by inflammatory effectors. However, other mechanisms involved in BA homeostasis counterbalance any significant impact on the serum BA profile., This study was supported by the CIBERehd (EHD15PI05/2016) and Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain (PI19/00819, PI20/00189, and PI20/01663 co-funded by European Regional Development Fund/European Social Fund, “Investing in your future”); Junta de Castilla y Leon (SA074P20); Fundació Marato TV3 (Ref. 201916/31), Spain; AECC Scientific Foundation (2017/2020), Spain; Interdisciplinary Center for Clinical Research (IZKF) at the University Hospital of Wuerzburg, Germany (Project A-E-384 to H.M.H.); grants PID2019-111669-RBI00, PID2020-115055RB-I00 from Agencia Estatal de Investigación (AEI), Spain; the AGAUR of the Generalidad de Cataluña SGR-2017-1112, Spain; and European Cooperation in Science & Technology (COST) Action CA17112. R.E.E was recipient of a predoctoral fellowship from “Junta de Castilla y León” and “Fondo Social Europeo” (EDU/574/2018). J.A. was recipient of a grant from Fundación Echebano (2020–2022).

Published
2022
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41. Complex multiple risk intervention to promote healthy behaviours in people between 45 to 75 years attended in primary health care (EIRA study): study protocol for a hybrid trial

Author

[Zabaleta-del-Olmo E] Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Gerència Territorial de Barcelona, Institut Català de la Salut, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain. Facultat d’infermeria, Universitat de Girona, Girona, Spain. [Pons-Vigués M, Casajuana-Closas M, López-Jiménez T, Martín-Cantera C, Bolíbar B] Institut Universitari d’Investigació en AtencióPrimària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain. [Pujol-Ribera E] Institut Universitari d’Investigació en AtencióPrimària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain. Gerència Territorial de Barcelona, Institut Català de la Salut, Barcelona, Spain. Facultat d’infermeria, Universitat de Girona, Girona, Spain. [Pons-Vigués M] Institut Universitari d’Investigació en AtencióPrimària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain. Facultat d’infermeria, Universitat de Girona, Girona, Spain. [Pombo H] Primary Care Research Unit of Bizkaia, Basque Health Service-Osakidetza, Bilbao, Spain. [Cabezas C] Deputy Directorate of Health Promotion, Public Health Agency, Department of Health, Goverment of Catalonia, Barcelona, Spain. [Martín-Borràs C] Faculty of Psychology, Education and Sport Sciences (FPCEE) Blanquerna, Ramon Llull University, Barcelona, Spain. Faculty of Health Sciences (FCS) Blanquerna, Ramon Llull Univesity, Barcelona, Spain. [Serrano-Blanco A, Rubio-Valera M] Parc Sanitari Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Llobera J, Leiva A, Vicens C, Vidal C] Gerència d’Atenció Primària de Mallorca, Institut de Investigació Sanitària de les Illes Balears IdISBa, Palma, Mallorca, Spain. [Campiñez M, Martín-Álvarez R] Primary Health Centre Vallcarca, Barcelona, Spain. [Maderuelo JA, García-Ortiz L] Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Health Service of Castilla y León (SACyL), Salamanca, Spain. [Recio JI] Department of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain. Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Health Service of Castilla y León (SACyL), Salamanca, Spain. [García-Ortiz L] Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Health Service of Castilla y León (SACyL), Salamanca, Spain. Department of Biomedical and Diagnostic Sciences, University of Salamanca, Salamanca, Spain. [Motrico E] Psychology Department, Universidad Loyola Andalucía, Sevilla, Spain. [Moreno-Peral P] Research Unit, Primary Care District of Málaga-Guadalhorce, Málaga, Spain. Institute of Biomedical Research in Málaga (IBIMA), Málaga, Spain. [Bellón JA] El Palo Health Center, Andalusian Health Service (SAS), Málaga, Spain. Department of Public Health and Psychiatry, University of Malaga, Málaga, Spain. Research Unit, Primary Care District of Málaga-Guadalhorce, Málaga, Spain. Institute of Biomedical Research in Málaga (IBIMA), Málaga, Spain. [Clavería A] Grupo I-Saúde, Instituto de Investigación Sanitaria Galicia-Sur (IISGS), Xerencia de Xestión Integrada de Vigo, Servizo Galego de Saúde (SERGAS), Universidade de Vigo, Vigo, Spain. [Aldecoa-Landesa S] Primary Health Centre Beiramar, Xerencia de Xestión Integrada Vigo, Servizo Galego de Saúde (SERGAS), Vigo, Spain. Grupo I-Saúde, Instituto de Investigación Sanitaria Galicia-Sur (IISGS), Xerencia de Xestión Integrada de Vigo, Servizo Galego de Saúde (SERGAS), Universidade de Vigo, Vigo, Spain. [Magallón-Botaya R] Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain and IDIAP Jordi Gol

Subjects
Atenció primària, Otros calificadores::Otros calificadores::/tendencias [Otros calificadores], Study Characteristics::Clinical Study::Clinical Trial [PUBLICATION CHARACTERISTICS], Instalaciones para Atención de Salud, Recursos Humanos y Servicios::Servicios de Salud::Servicios Preventivos de Salud::Educación en Salud::Promoción de la Salud [ATENCIÓN DE SALUD], Promoció de la salut, Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Health Education::Health Promotion [HEALTH CARE], Administración de los Servicios de Salud::Manejo de Atención al Paciente::Atención Integral de Salud::Atención Primaria de Salud [ATENCIÓN DE SALUD], Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [HEALTH CARE], Características de los Estudios::Estudio Clínico::Ensayo Clínico [CARACTERÍSTICAS DE PUBLICACIONES], Other subheadings::Other subheadings::/trends [Other subheadings], Assaigs clínics
Published
2021

42. Analysis of the Costs Associated With the Elective Evaluation of Patients Labelled as Allergic to Beta-Lactams or Nonsteroidal Antiinflamatory Agents

Author

Sobrino-García, Miriam, Moreno, Esther M., Muñoz-Bellido, Francisco J., Gracia-Bara, Maria T., Laffond, Elena, Doña, Inmaculada, Martín, Cristina, Macías, Eva M., de Arriba, Sonia, Campanón, Valle, Gallardo, Alicia, Dávila, Ignacio, [Sobrino-Garcia, Miriam] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Moreno, Esther M.] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Munoz-Bellido, Francisco J.] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Gracia-Bara, Maria T.] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Laffond, Elena] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Martin, Cristina] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Macias, Eva M.] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [de Arriba, Sonia] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Campanon, Valle] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Gallardo, Alicia] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Davila, Ignacio] Univ Hosp Salamanca, Allergy Serv, Salamanca, Spain, [Moreno, Esther M.] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Munoz-Bellido, Francisco J.] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Gracia-Bara, Maria T.] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Laffond, Elena] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Martin, Cristina] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Macias, Eva M.] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [de Arriba, Sonia] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Davila, Ignacio] Inst Biomed Res Salamanca IBSAL, Salamanca, Spain, [Moreno, Esther M.] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Munoz-Bellido, Francisco J.] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Laffond, Elena] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Macias, Eva M.] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [de Arriba, Sonia] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Davila, Ignacio] Univ Salamanca, Fac Med, Dept Biomed & Diagnost Sci, Salamanca, Spain, [Moreno, Esther M.] Salamanca Univ Hosp, Asthma Allerg & Adverse React ARADyAL, Network Cooperat Res Hlth, Inst Salud Carlos III, Salamanca, Spain, [Dona, Inmaculada] Salamanca Univ Hosp, Asthma Allerg & Adverse React ARADyAL, Network Cooperat Res Hlth, Inst Salud Carlos III, Salamanca, Spain, [Davila, Ignacio] Salamanca Univ Hosp, Asthma Allerg & Adverse React ARADyAL, Network Cooperat Res Hlth, Inst Salud Carlos III, Salamanca, Spain, [Dona, Inmaculada] Univ Hosp Malaga, Allergy Serv, Malaga, Spain, [Dona, Inmaculada] Biomed Res Inst Malaga IBIMA, Malaga, Spain, [Sobrino-García,M, Moreno,EM, Muñoz-Bellido,FJ, Gracia-Bara,MT, Laffond,E, Martín,C, Macías,EM, de Arriba,S, Campanón,V, Gallardo,A, Dávila,I] Allergy Service, University Hospital of Salamanca, Salamanca, Spain. [Moreno,EM, Dávila,I] Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain. [Moreno,EM, Dávila,I] Department of Biomedical and Diagnostic Sciences, Faculty of Medicine, University of Salamanca, Salamanca, Spain. [Moreno,EM, Doña,I, and Dávila,I] Asthma, Allergic and Adverse Reactions (ARADyAL), Network for Cooperative Research in Health of Instituto de Salud Carlos III, Salamanca University Hospital, Salamanca, Spain. [Doña,I] Allergy Service, University Hospital of Malaga, Malaga, Spain. [Doña,I] Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain.

Subjects
History, Hypersensitivity reactions, Reported penicillin allergy, Adolescents, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], non-steroidal anti-inflammatory drug, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies [Medical Subject Headings], Antiinflammatory drugs, cost, Diagnosis, Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams [Medical Subject Headings], Persons::Persons::Age Groups::Child [Medical Subject Headings], Health Care::Health Care Economics and Organizations::Economics::Costs and Cost Analysis [Medical Subject Headings], Persons::Persons::Age Groups::Adult [Medical Subject Headings], Aspirin desensitization, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents::Anti-Inflammatory Agents, Non-Steroidal [Medical Subject Headings], Penicilinas, Beta-lactamas, Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins [Medical Subject Headings], Classification, Management, Costos y análisis de costo, Diseases::Chemically-Induced Disorders::Drug-Related Side Effects and Adverse Reactions::Drug Hypersensitivity [Medical Subject Headings], penicillin, Impact, delabelling, Hipersensibilidad a las drogas, Antiinflamatorios no esteroideos, beta-lactam, drug hypersensitivity, drug allergy
Abstract

Introduction: Being labelled as allergic to different drugs results in patients receiving other treatments, which are more toxic, less effective and more expensive. We aimed to analyze different studies of the costs of drug hypersensitivity assessment. Methods: A bibliographic search on studies regarding this issue was performed, including the available scientific evidence up to June 2020. We searched three databases with terms related to costs and allergy testing in drug hypersensitivity reactions. Results: Our search revealed 1,430 publications, of which 20 met the inclusion criteria. In the manuscript, prospective studies evaluating the costs of the evaluation of patients with suspected allergy to beta-lactams or non-steroidal anti-inflammatory drugs are analyzed. Also, comment is made on the costs associated with incorrect labeling as non-steroidal anti-inflammatory drug or penicillin hypersensitivity. Conclusions: Taking all costs into account, the study of drug hypersensitivity is not expensive, particularly considering the economic and clinical consequences of labeling a patient with hypersensitivity to drugs. Yes

Published
2020
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43. The Neurokinin-1 Receptor Antagonist Aprepitant, a New Drug for the Treatment of Hematological Malignancies: Focus on Acute Myeloid Leukemia

Author

Muñoz, Miguel, Coveñas, Rafael, [Muñoz,M] Research Laboratory on Neuropeptides (IBIS), Virgen del Rocío University Hospital, Sevilla, Spain. [Coveñas,R] Institute of Neurosciences of Castilla y León (INCYL), Laboratory of Neuroanatomy of the Peptidergic Systems, University of Salamanca, Salamanca, Spain., and This research was funded by 'Programa XI: Financiación de Unidades de Excelencia de la Universidad de Salamanca' (University of Salamanca, Spain).

Subjects
Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myeloid, Acute [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Site::Hematologic Neoplasms [Medical Subject Headings], Receptores de neuroquinina-1, Apoptosis, Substance P, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Tachykinin::Receptors, Neurokinin-1 [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Physiological Processes::Stress, Physiological::Oxidative Stress [Medical Subject Headings], Leucemia mieloide aguda, AML, Anatomy::Cells::Cells, Cultured::Cell Line [Medical Subject Headings], hemic and lymphatic diseases, Non-solid tumor, Chemicals and Drugs::Biological Factors::Inflammation Mediators::Autacoids::Kinins::Tachykinins::Substance P [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Protein Isoforms [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [Medical Subject Headings], Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Pain [Medical Subject Headings], Antineoplásicos, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis [Medical Subject Headings], Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Up-Regulation [Medical Subject Headings], NK-1R, Sustancia P, Anti-leukemic, Aprepitant, Neoplasias hematológicas
Abstract

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy. To treat the disease successfully, new therapeutic strategies are urgently needed. One of these strategies can be the use of neurokinin-1 receptor (NK-1R) antagonists (e.g., aprepitant), because the substance P (SP)/NK-1R system is involved in cancer progression, including AML. AML patients show an up-regulation of the NK-1R mRNA expression; human AML cell lines show immunoreactivity for both SP and the NK-1R (it is overexpressed: the truncated isoform is more expressed than the full-length form) and, via this receptor, SP and NK-1R antagonists (aprepitant, in a concentration-dependent manner) respectively exert a proliferative action or an antileukemic effect (apoptotic mechanisms are triggered by promoting oxidative stress via mitochondrial Ca++ overload). Aprepitant inhibits the formation of AML cell colonies and, in combination with chemotherapeutic drugs, is more effective in inducing cytotoxic effects and AML cell growth blockade. NK-1R antagonists also exert an antinociceptive effect in myeloid leukemia-induced bone pain. The antitumor effect of aprepitant is diminished when the NF-κB pathway is overactivated and the damage induced by aprepitant in cancer cells is higher than that exerted in non-cancer cells. Thus, the SP/NK-1R system is involved in AML, and aprepitant is a promising antitumor strategy against this hematological malignancy. In this review, the involvement of this system in solid and non-solid tumors (in particular in AML) is updated and the use of aprepitant as an anti-leukemic strategy for the treatment of AML is also mentioned (a dose of aprepitant (>20 mg/kg/day) for a period of time according to the response to treatment is suggested). Aprepitant is currently used in clinical practice as an anti-nausea medication. Yes

Published
2020

44. Meeting Report – Workshop ‘Actin-based mechanosensation and force generation in health and disease’

Author

Miguel Vicente-Manzanares, Anna Polesskaya, EMBO, Laboratoire de Biologie Structurale de la Cellule (BIOC), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), University of Salamanca - Spain, and University of Salamanca

Subjects
Force generation, 0303 health sciences, Mechanosensation, Library science, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, 02 engineering and technology, Cell Biology, Unesco world heritage, Biology, 021001 nanoscience & nanotechnology, Actin cytoskeleton, 3. Good health, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], 03 medical and health sciences, 11. Sustainability, Cellular motility, 0210 nano-technology, 030304 developmental biology
Abstract

International experts in the fields of cellular motility, force generation and mechanosensation met in Baeza, a UNESCO World Heritage city, from the 10th to the 13th of November, 2019. The meeting, part of the ‘Current Trends in Biomedicine’ series, took place at the ‘Sede Antonio Machado’, a beautiful 17th century building turned into a conference center of the Universidad Internacional de Andalucía (UNIA), which sponsored the event. The meeting was organized by Alexis Gautreau, Pekka Lappalainen and Miguel Vicente-Manzanares, with the support of the European Molecular Biology Organization (EMBO) and the Spanish-based company IMPETUX. Fifty scientists presented recent results during the talks, poster sessions and thematic discussions. As Baeza itself served as a crossroads of medieval Christian, Moorish and Jewish cultures, the meeting brought together cell biologists, biochemists, biophysicists and engineers from around the world that provided an integrated vision of the role of the actin cytoskeleton, force generation and mechanosensation in diverse physiological processes and pathologies., EMBO and IMPETUX for their support, and speakers for critical reading of the manuscript. The meeting was funded by UNIA with support from EMBO.

Published
2020
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45. Controlling All‐Optical Helicity‐Dependent Switching in Engineered Rare‐Earth Free Synthetic Ferrimagnets

Author

Russell P. Cowburn, Gregory Malinowski, Eduardo Martínez, Unai Atxitia, Michel Hehn, Jung-Wei Liao, Victor Raposo, Dorothée Petit, Liam O'Brien, Pierre Vallobra, Tarun Vemulkar, Stéphane Mangin, Cavendish Laboratory, University of Cambridge [UK] (CAM), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Department of Physics - University of Liverpool, University of Liverpool, Department of Physics [Berlin], Freie Universität Berlin, Department of Applied Physics of the Faculty of Science University of Salamanca, Department of Applied physics of the Faculty of Science University of Salamanca, IMPACT N4S, and ANR-15-IDEX-0004,LUE,Isite LUE(2015)

Subjects
Materials science, Magnetism, General Chemical Engineering, General Physics and Astronomy, Medicine (miscellaneous), 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Genetics and Molecular Biology (miscellaneous), Condensed Matter::Materials Science, ferromagnets, Ferrimagnetism, Curie, Computational physics, Antiferromagnetism, General Materials Science, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], lcsh:Science, ComputingMilieux_MISCELLANEOUS, Full Paper, Condensed matter physics, 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik, General Engineering, Full Papers, 021001 nanoscience & nanotechnology, Helicity, 0104 chemical sciences, synthetic ferrimagnets, Ferromagnetism, Femtosecond, Curie temperature, lcsh:Q, Condensed Matter::Strongly Correlated Electrons, 2202.08 Magnetismo, 0210 nano-technology, all‐optical switching
Abstract

All‐optical helicity‐dependent switching in ferromagnetic layers has revealed an unprecedented route to manipulate magnetic configurations by circularly polarized femtosecond laser pulses. In this work, rare‐earth free synthetic ferrimagnetic heterostructures made from two antiferromagnetically exchange coupled ferromagnetic layers are studied. Experimental results, supported by numerical simulations, show that the designed structures enable all‐optical switching which is controlled, not only by light helicity, but also by the relative Curie temperature of each ferromagnetic layer. Indeed, through the antiferromagnetic exchange coupling, the layer with the larger Curie temperature determines the final orientation of the other layer and so the synthetic ferrimagnet. For similar Curie temperatures, helicity‐independent back switching is observed and the final magnetic configuration is solely determined by the initial magnetic state. This demonstration of electrically‐detected, optical control of engineered rare‐earth free heterostructures opens a novel route toward practical opto‐spintronics., All‐optical helicity‐dependent switching in synthetic ferrimagnetic samples made of two exchanged coupled ferromagnetic layers is shown to depend on the respective Curie temperature of each layer. By varying the CoFeB layer thickness, its Curie temperature can be tuned. Consequently, the switching is set not only by the light helicity but also by the CoFeB thickness.

Published
2019
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46. Complex multiple risk intervention to promote healthy behaviours in people between 45 to 75 years attended in primary health care (EIRA study): study protocol for a hybrid trial

Author

Mariona Pons-Vigués, Patricia Moreno-Peral, Antoni Serrano-Blanco, Luis García-Ortiz, Caterina Vicens, Haizea Pombo, Susana Aldecoa-Landesa, Manuel Campiñez, Clara Vidal, Carmen Cabezas-Peña, Remedios Martín-Álvarez, Joan Llobera, José-Ignacio Recio, Edurne Zabaleta-del-Olmo, Carme Martin-Borràs, Rosa Magallón-Botaya, Tomàs López-Jiménez, Alfonso Leiva, Marc Casajuana-Closas, José-Ángel Maderuelo, Carlos Martín-Cantera, Enriqueta Pujol-Ribera, J. Bellon, Bonaventura Bolíbar, Emma Motrico, Ana Clavería, Maria Rubio-Valera, [Zabaleta-del-Olmo E] Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Gerència Territorial de Barcelona, Institut Català de la Salut, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain. Facultat d’infermeria, Universitat de Girona, Girona, Spain. [Pons-Vigués M, Casajuana-Closas M, López-Jiménez T, Martín-Cantera C, Bolíbar B] Institut Universitari d’Investigació en AtencióPrimària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain. [Pujol-Ribera E] Institut Universitari d’Investigació en AtencióPrimària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain. Gerència Territorial de Barcelona, Institut Català de la Salut, Barcelona, Spain. Facultat d’infermeria, Universitat de Girona, Girona, Spain. [Pons-Vigués M] Institut Universitari d’Investigació en AtencióPrimària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain. Facultat d’infermeria, Universitat de Girona, Girona, Spain. [Pombo H] Primary Care Research Unit of Bizkaia, Basque Health Service-Osakidetza, Bilbao, Spain. [Cabezas C] Deputy Directorate of Health Promotion, Public Health Agency, Department of Health, Goverment of Catalonia, Barcelona, Spain. [Martín-Borràs C] Faculty of Psychology, Education and Sport Sciences (FPCEE) Blanquerna, Ramon Llull University, Barcelona, Spain. Faculty of Health Sciences (FCS) Blanquerna, Ramon Llull Univesity, Barcelona, Spain. [Serrano-Blanco A, Rubio-Valera M] Parc Sanitari Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Llobera J, Leiva A, Vicens C, Vidal C] Gerència d’Atenció Primària de Mallorca, Institut de Investigació Sanitària de les Illes Balears IdISBa, Palma, Mallorca, Spain. [Campiñez M, Martín-Álvarez R] Primary Health Centre Vallcarca, Barcelona, Spain. [Maderuelo JA, García-Ortiz L] Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Health Service of Castilla y León (SACyL), Salamanca, Spain. [Recio JI] Department of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain. Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Health Service of Castilla y León (SACyL), Salamanca, Spain. [García-Ortiz L] Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Health Service of Castilla y León (SACyL), Salamanca, Spain. Department of Biomedical and Diagnostic Sciences, University of Salamanca, Salamanca, Spain. [Motrico E] Psychology Department, Universidad Loyola Andalucía, Sevilla, Spain. [Moreno-Peral P] Research Unit, Primary Care District of Málaga-Guadalhorce, Málaga, Spain. Institute of Biomedical Research in Málaga (IBIMA), Málaga, Spain. [Bellón JA] El Palo Health Center, Andalusian Health Service (SAS), Málaga, Spain. Department of Public Health and Psychiatry, University of Malaga, Málaga, Spain. Research Unit, Primary Care District of Málaga-Guadalhorce, Málaga, Spain. Institute of Biomedical Research in Málaga (IBIMA), Málaga, Spain. [Clavería A] Grupo I-Saúde, Instituto de Investigación Sanitaria Galicia-Sur (IISGS), Xerencia de Xestión Integrada de Vigo, Servizo Galego de Saúde (SERGAS), Universidade de Vigo, Vigo, Spain. [Aldecoa-Landesa S] Primary Health Centre Beiramar, Xerencia de Xestión Integrada Vigo, Servizo Galego de Saúde (SERGAS), Vigo, Spain. Grupo I-Saúde, Instituto de Investigación Sanitaria Galicia-Sur (IISGS), Xerencia de Xestión Integrada de Vigo, Servizo Galego de Saúde (SERGAS), Universidade de Vigo, Vigo, Spain. [Magallón-Botaya R] Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain, IDIAP Jordi Gol, and Universidad de Sevilla. Departamento de Psicología Evolutiva y de la Educación

Subjects
Male, Otros calificadores::Otros calificadores::/tendencias [Otros calificadores], Cost-Benefit Analysis, Instalaciones para Atención de Salud, Recursos Humanos y Servicios::Servicios de Salud::Servicios Preventivos de Salud::Educación en Salud::Promoción de la Salud [ATENCIÓN DE SALUD], Health Behavior, humanos, Psychological intervention, Health Risk Behaviors, 0302 clinical medicine, Surveys and Questionnaires, Fumar, evaluación de programas y proyectos de salud, 030212 general & internal medicine, Características de los Estudios::Estudio Clínico::Ensayo Clínico [CARACTERÍSTICAS DE PUBLICACIONES], conducta sanitaria, mediana edad, Primary health care, anciano, lcsh:Public aspects of medicine, 030503 health policy & services, Smoking, Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Health Education::Health Promotion [HEALTH CARE], CDATA[Health promotion, Cost-effectiveness analysis, CDATA[Mediterranean diet, Middle Aged, Ejercicio físico, Other subheadings::Other subheadings::/trends [Other subheadings], Atenció primària, Research Design, Female, Administración de los Servicios de Salud::Manejo de Atención al Paciente::Atención Integral de Salud::Atención Primaria de Salud [ATENCIÓN DE SALUD], Análisis productividad costes, 0305 other medical science, medicine.medical_specialty, Implementation research, Promoció de la salut, Intervenciones complejas, Comportamiento sanitario, 03 medical and health sciences, Complex interventions, Nursing, características del estudio::estudio clínico::ensayo clínico [CARACTERÍSTICAS DE PUBLICACIONES], Intervention (counseling), Mediterranean diet, Study Characteristics::Clinical Study::Clinical Trial [PUBLICATION CHARACTERISTICS], CDATA[Implementation research, CDATA[Smoking, medicine, Humans, CDATA[Primary health care, Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [HEALTH CARE], Primary care (Medicine), Aged, Primary Health Care, business.industry, Physical activity, Public health, Public Health, Environmental and Occupational Health, Transtheoretical model, Correction, lcsh:RA1-1270, Atención primaria, Dieta mediterránea, Hybrid trial, CDATA[Physical activity, Promoción sanitaria, Health promotion, Spain, Health behaviour, administración de los servicios de salud::gestión de la atención al paciente::atención integral de salud::atención primaria de la salud [ATENCIÓN DE SALUD], Biostatistics, business, CDATA[Hybrid trial, diseño de la investigación, Program Evaluation, Assaigs clínics
Abstract

CDATA[CDATA[Background: Health promotion is a key process of current health systems Primary Health Care (PHC) is the ideal setting for health promotion but multifaceted barriers make its integration difficult in the usual care. The majority of the adult population engages two 01 more risk behaviours, that is why a multiple intervention might be more effective and efficient The primary objectives are to evaluate the effectiveness, the cost effectiveness and an implementation strategy of a complex multiple risk intervention to promote healthy behaviours in people between 45 to 75 years attended in PHC. CDATA[CDATA[Methods: This study is a cluster randomised controlled hybrid type 2 trial with two parallel groups comparing a complex multiple risk behaviour intervention with usual care It will be carried out in 26 PHC centres in Spam The study focuses on people between 45 and 75 years who carry out two or more of the following unhealthy behaviours tobacco use, low adherence to the Mediterranean dietary pattern or insufficient physical activity level The intervention is based on the Transtheoretical Model and it will be made by physicians and nurses in the routine care of PHC practices according to the conceptual framework of the '5A's It will have a maximum duration of 12 months and it will be carried out to three different levels (individual, group and community) Incremental cost per quality adjusted life year gamed measured by the tanffs of the EuioQo! 5D questionnaire will be estimated. The implementation strategy is based on the 'Consolidated Framework for Implementation Research, a set of discrete implementation strategies and an evaluation framework. CDATA[CDATA[Discussion: EIRA study will determine the effectiveness and cost effectiveness of a complex multiple risk intervention and will provide a better understanding of implementation processes of health promotion interventions in PHC setting. It may contribute to increase knowledge about the individual and structural barriers that affect implementation of these interventions and to quantify the contextual factors that moderate the effectiveness of implementation., This project is funded by the Institute of Health Carlos III, Ministry of Economy and Competitiveness (Spain), with a grant for research projects on health (PI15/00114) through the Network for Prevention and Health Promotion in Primary Care (redIAPP, RD12/0005/0001; RD16/0007/0001), and by European Union ERDF funds, (European Regional Development Fund). This study was also funded by the Health Department (SLT002/16/00112) from the Generalitat of Catalunya.

Published
2018

47. Glycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK study

Author

Gómez-Sánchez, Leticia, García-Ortiz, Luis, Patino-Alonso, Maria C., Recio-Rodríguez, José I., Feuerbach, Natalia, Martí, Ruth, Agudo-Conde, Cristina, Rodríguez-Sánchez, Emiliano, Maderuelo-Fernández, Jose A., Ramos, Rafel, Gómez-Marcos, Manuel A., MARK Group, [Gómez-Sánchez L] Primary Care Research Unit, the Alamedilla Health Center, Castilla and León, Health Service (SACyL) Salamanca, Spain. [García-Ortiz L] Primary Care Research Unit, the Alamedilla Health Center, Castilla and León, Health Service (SACyL) Salamanca, Spain. Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain. Biomedical and Diagnostic Sciences Department, University of Salamanca, Salamanca, Spain. [Patino-Alonso MC] Primary Care Research Unit, the Alamedilla Health Center, Castilla and León, Health Service (SACyL) Salamanca, Spain. Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain. Statistics Department, University of Salamanca, Salamanca, Spain. [Recio-Rodríguez JI] Primary Care Research Unit, the Alamedilla Health Center, Castilla and León, Health Service (SACyL) Salamanca, Spain. Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain. Department of Nursing and Physiotherapy, University of Salamanca, Salamanca, Spain. [Feuerbach N] San Agustín Health Center, Illes Balears Health Service (IBSALUT), Palma of Mallorca, Spain. [Martí R] Unitat of Suport the Recerca of Girona, Institut Universitari d’Investigació in Atenció Primària Jordi Gol (IDIAP Jordi Gol), Girona, Spain. Institut d’Investigació Biomèdica of Girona Dr. Josep Trueta (IDBGI), Girona, Spain. [Agudo-Conde C, Maderuelo-Fernández JA] Primary Care Research Unit, the Alamedilla Health Center, Castilla and León, Health Service (SACyL) Salamanca, Spain. Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain. [Rodríguez-Sánchez E, Gómez-Marcos MA] Primary Care Research Unit, the Alamedilla Health Center, Castilla and León, Health Service (SACyL) Salamanca, Spain. Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain. Department of Medicine, University of Salamanca, Salamanca, Spain. [Ramos R] Unitat of Suport the Recerca of Girona, Institut Universitari d’Investigació in Atenció Primària Jordi Gol (IDIAP Jordi Gol), Girona, Spain. Institut d’Investigació Biomèdica of Girona Dr. Josep Trueta (IDBGI), Girona, Spain. Departament of Ciències Mèdiques, Facultat of Medicina, Universitat of Girona, Girona, Spain. [MARK Group] MARK Group, redIAPP: Research Network in Preventive Activities and Health Promotion, Girona, Spain, and IDIAP Jordi Gol

Subjects
hidratos de carbono::azúcares::monosacáridos::hexosas::glucosa::glucosa sanguínea [COMPUESTOS QUÍMICOS Y DROGAS], Male, endocrine system diseases, Blood Pressure, Biochemistry, Vascular Medicine, factores biológicos::biomarcadores [COMPUESTOS QUÍMICOS Y DROGAS], Stiffness, 0302 clinical medicine, Endocrinology, lcsh:Science, Pulse wave velocity, mediana edad, anciano, Organic Compounds, adulto, Postprandial Period, Type 2 Diabetes, Blood, Cardiovascular diseases, Marcadors bioquímics, Physical Sciences, Blood Flow Velocity, presión sanguínea, medicine.medical_specialty, HbA1c, glucosa sanguínea, Endocrine Disorders, European Continental Ancestry Group, Materials Science, enfermedades cardiovasculares, Carbohydrates, fenómenos fisiológicos respiratorios y circulatorios::fenómenos fisiológicos cardiovasculares::rigidez vascular [FENÓMENOS Y PROCESOS], Biological Factors::Biomarkers [CHEMICALS AND DRUGS], White People, 03 medical and health sciences, Vascular Stiffness, período postprandial, Diabetes Mellitus, Humans, Hemoglobin, hiperglucemia, análisis de la onda del pulso, Fenómenos Fisiológicos Orales y del Sistema Digestivo::Fenómenos Fisiológicos del Sistema Digestivo::Periodo Posprandial [FENÓMENOS Y PROCESOS], Glycemic, Aged, Glycated Hemoglobin, Medicine and health sciences, Pharmacology, lcsh:R, Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Vascular Stiffness [PHENOMENA AND PROCESSES], Chemical Compounds, Proteins, nutritional and metabolic diseases, Diabetology, medicine.disease, estado prediabético, Cross-Sectional Studies, Glucose, Glucèmia, Diabetes Mellitus, Type 2, Hyperglycemia, lcsh:Q, grupo de ascendencia continental europea, Biomarkers, estudios transversales, Blood Glucose, Physiology, humanos, Artèries -- Malalties, lcsh:Medicine, Type 2 diabetes, 030204 cardiovascular system & hematology, rigidez vascular, Risk Factors, Fenómenos Fisiológicos Circulatorios y Respiratorios::Fenómenos Fisiológicos Cardiovasculares::Rigidez Vascular [FENÓMENOS Y PROCESOS], Diabetes diagnosis and management, 030212 general & internal medicine, Prediabetes, Multidisciplinary, Monosaccharides, Diabetes, Drugs, personas::grupos de población::grupos de población continentales::grupo de ascendencia continental europea [DENOMINACIONES DE GRUPOS], Middle Aged, Blood Sugar, Body Fluids, Chemistry, Antihypertensive Drugs, Female, Anatomy, Research Article, Adult, Sang - Circulació, Material Properties, Blood sugar, Pulse Wave Analysis, Prediabetic State, Diabetes mellitus, Internal medicine, medicine, factores de riesgo, Mechanical Properties, Ankle Brachial Index, tobillo, Biology and life sciences, business.industry, velocidad del flujo sanguíneo, Organic Chemistry, Type 2 Diabetes Mellitus, Carbohydrates::Monosaccharides::Hexoses::Glucose::Blood Glucose [CHEMICALS AND DRUGS], Persons::Population Groups::Continental Population Groups::European Continental Ancestry Group [NAMED GROUPS], Diagnostic medicine, Metabolic Disorders, Arterial stiffness, fenómenos fisiológicos orales y del sistema digestivo::fenómenos fisiológicos del sistema digestivo::período posprandial [FENÓMENOS Y PROCESOS], Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Postprandial Period [PHENOMENA AND PROCESSES], Ankle, business, Arteries -- Diseases, Biomakers, índice tobillo-brazo
Abstract

Background Effect of prediabetes and normal glucose on arterial stiffness remains controversial. The primary aim of this study was to investigate the relationship of fasting plasma glucose (FPG), postprandial glucose (PG) and glycosylated haemoglobin (HbA1c) with brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) in Caucasian adults. The secondary aim was to analyse this relationship by glycaemic status. Methods Cross-sectional study. Setting: Primary care. Participants: 2,233 subjects, 35-74 years. Measures: FPG (mg/dL) and HbA1c (%) of all subjects were measured using standard automated enzymatic methods. PG (mg/dL) was self-measured at home two hours after meals (breakfast, lunch and dinner) for one day using an Accu-chek (R) glucometer. CAVI was measured using a VaSera VS-1500 (R) device (Fukuda Denshi), and baPWV was calculated using a validated equation. Results CAVI and baPWV values were significantly higher in subjects with diabetes mellitus than in glucose normal and prediabetes groups (p, This work was supported by grants from the Spanish Ministry of Science and Innovation (MICINN), the Carlos III Health Institute/European Regional Development Fund (ERDF) (MICINN, ISCIII/FEDER) (Red RedIAPP RD06/0018, Research Groups: RD16/0007/0003, RD16/0007/0004, RD16/0007/0008), the Health Research Fund (PI10/01088, PI10/02077, PI10/02043; PI13/01930), and the Regional Health Management of Castile and Leon (GRS 635/A/11; GRS 906/B/14).

Published
2017

48. Nonlinear up-conversion of a polarization Möbius strip with half-integer optical angular momentum

Author

Martin Luttmann, Mekha Vimal, Matthieu Guer, Jean-François Hergott, Antonio Z. Khoury, Carlos Hernández-García, Emilio Pisanty, Thierry Ruchon, Attophysique (ATTO), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Serveurs Laser (SLIC), Instituto de Física, Universidade Federal Fluminense, University of Salamanca, CIBERehd, Salamanca, and King‘s College London

Subjects
[PHYS]Physics [physics], Multidisciplinary
Abstract

Symmetries and conservation laws of energy, linear momentum, and angular momentum play a central role in nonlinear optics. Recently, paraxial light fields with nontrivial topology have been attracting a keen interest. Despite not being eigenstates of the orbital and spin angular momenta (OAM and SAM), they are eigenstates of the generalized angular momentum (GAM) operator—a mixture of the OAM and SAM operators with fractional eigenvalues. By driving high harmonic generation with a polarization Möbius strip carrying a half-integer GAM charge and implementing angular momentum characterization methods in the extreme ultraviolet range, we demonstrate the linear scaling of the GAM with the harmonic order, each harmonic carrying a precise half-integer GAM charge. Our work shows that beyond SAM and OAM, the GAM is, in some situations, an appropriate quantum number. It paves the way for finer manipulations and applications of light beams containing fractional-order polarization singularities.

Published
2023
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49. Advances in Practical Applications of Agents, Multi-Agent Systems, and Cognitive Mimetics. The PAAMS Collection

Author

Mathieu, Philippe, Dignum, Frank, Novais, Paulo, de la Prieta, Fernando, Systèmes Multi-Agents et Comportements (SMAC), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Umeå University, Sweden, University of Minho [Braga], and University of Sousse, Tunisia and University of Salamanca, Spain

Subjects
[INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Practical Applications, Agents, Multi-Agent Systems, Cognitive Mimetics, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

International audience; This volume presents the papers that were accepted for the 2023 edition of PAAMS. These articles report on the application and validation of agent-based models, methods, and technologies in a number of key application areas, including: cognitive mimetic, simulating complex systems, agents for social good, advanced models for learning, agent- based programming, distributed data analysis, automatic planning, decision-making, social interactions, formal and theoretic models, self-adaptation, mobile edge computing, swarms, and task allocation.

Published
2023
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50. Systems biology of infectious diseases: a focus on fungal infections

Author

Michael Bromley, Philippe Pierre, Ivo Gut, Lisa Rizzetto, Rodrigo Santamaría, Wanseon Lee, Duccio Cavalieri, Brian Miller, Misha Kapushesky, Teresa Zelante, Luigina Romani, Manuel A. S. Santos, Paul Bowyer, University of Salamanca - Spain, University of Salamanca, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), University of Manchester [Manchester], Università degli Studi di Perugia (UNIPG), European Bioinforrmatics Institute (UK) (EBI), École de biologie industrielle (EBI), AlerGenetica (UK), AlerGenetica, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Universidade de Aveiro, Universidad de Salamanca, Università degli Studi di Firenze = University of Florence (UniFI), and Università degli Studi di Perugia = University of Perugia (UNIPG)

Subjects
Proteomics, Antifungal Agents, MESH: Th17 Cells, Disease, MESH: Drug Design, Bioinformatics, MESH: Receptors, Pattern Recognition, MESH: Molecular Targeted Therapy, Candida albicans, Immunology and Allergy, MESH: Animals, MESH: Immune Evasion, MESH: Genetic Variation, Molecular Targeted Therapy, Organism, MESH: Cytokines, 0303 health sciences, MESH: Proteomics, Systems Biology, Hematology, 3. Good health, Drug development, MESH: Systems Biology, Receptors, Pattern Recognition, MESH: Genome, Fungal, Host-Pathogen Interactions, MESH: Communicable Diseases, [SDV.IMM]Life Sciences [q-bio]/Immunology, Cytokines, MESH: Aspergillus fumigatus, Genome, Fungal, MESH: Immune Tolerance, Systems biology, Host–pathogen interaction, Immunology, Computational biology, Biology, Communicable Diseases, Underlying infection, 03 medical and health sciences, MESH: Mycoses, Immune Tolerance, Animals, Humans, Immune Evasion, 030304 developmental biology, MESH: Humans, 030306 microbiology, MESH: Candida albicans, Aspergillus fumigatus, MESH: Host-Pathogen Interactions, MESH: Biological Markers, Genetic Variation, Th1 Cells, MESH: Antifungal Agents, Microarray Analysis, MESH: Microarray Analysis, MESH: Th1 Cells, Mycoses, Infectious disease (medical specialty), Drug Design, Th17 Cells, Biomarkers
Abstract

International audience; The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources.

Published
2011
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