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463 results on '"University of Skopje"'

1. Short- and Long-term Health Effects of Air Pollution in Poland (EP-PARTICLES)

Author: Charles University, Czech Republic, University of Liverpool, University of Skopje, University of Lodz, and Lukasz Kuzma, Principal Investigator
Published: 2024

2. Intraoperative Imaging of Lymph Nodes

Author: U.S. National Science Foundation and Ss. Cyril and Methodius University of Skopje, Macedonia
Published: 2024

3. Changes in Dietary Behaviours During the COVID-19 Outbreak Confinement in the Adult Population (COVIDiet_Int) (COVIDiet_Int)

Author: Agricultural University of Athens, University of Zagreb, University of Belgrade, Institute of Technology, Sligo, University of Sarajevo, Lithuanian University of Health Sciences, Jozef Stefan Institute, University of Southern Denmark, Institut Za Javno Zdeavlje, University of Skopje, Poznan University of Life Sciences, Bezmialem Vakif University, Centro Hospitalar e Universitário de Coimbra, E.P.E., Kuwait University, Universidad Nacional de Colombia, Manay Rachna International institute of Research and Studies, and Celia Rodríguez Pérez, Associate Professor in Nutrition and Food Science
Published: 2022

4. Sentinel Lymph Node Mapping With Near Infrared Fluorescent Markers

Author: Ss. Cyril and Methodius University of Skopje, Macedonia and Viktor Gruev, PhD, Professor
Published: 2022

5. Proteomic Prediction and Renin Angiotensin Aldosterone System Inhibition Prevention Of Early Diabetic nephRopathy In TYpe 2 Diabetic Patients With Normoalbuminuria (PRIORITY)

Author: Mosaiques Diagnostics GmbH, University Medical Center Groningen, University of Glasgow, Istituto Di Ricerche Farmacologiche Mario Negri, Univerzita Karlova v Praze, Geniko Nosokomeio Athinas Ippokrateio, Institut Klinické a Experimentální Mediciny Praze, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Klinikum St. Georg Leipzig, Cyril and Methodius University in Skopje, Hannover Clinical Trial Center, European Commission, Diabetes Vascular Research Foundation Hoogeveen, Universitair Ziekenhuis Gent, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Stichting VUMC, Diabetologen Hessen, and Peter Rossing, Professor, Chief Physician, MD, DMSc
Published: 2018

6. Aging at work: A review of recent trends and future direction

Author: Saints Cyril and Methodius University in Skopje (North Macedonia), Fondo Europeo de Desarrollo Regional (FEDER), Barakovic Husic, Jasmina, Melero Muñoz, Francisco José, Barakovic, Sabina, Lameski, Petre, Zdravevski, Eftim, Maresova, Petra, Krejcar, Ondrej, Chorbev, Ivan, Garcia dos Santos, Nuno Manuel, Trajkovik, Vladimir, Saints Cyril and Methodius University in Skopje (North Macedonia), Fondo Europeo de Desarrollo Regional (FEDER), Barakovic Husic, Jasmina, Melero Muñoz, Francisco José, Barakovic, Sabina, Lameski, Petre, Zdravevski, Eftim, Maresova, Petra, Krejcar, Ondrej, Chorbev, Ivan, Garcia dos Santos, Nuno Manuel, and Trajkovik, Vladimir
Abstract: Demographic data suggest a rapid aging trend in the active workforce. The concept of aging at work comes from the urgent requirement to help the aging workforce of the contemporary industries to maintain productivity while achieving a work and private life balance. While there is plenty of research focusing on the aging population, current research activities on policies covering the concept of aging at work are limited and conceptually different. This paper aims to review publications on aging at work, which could lead to the creation of a framework that targets governmental decision-makers, the non-governmental sector, the private sector, and all of those who are responsible for the formulation of policies on aging at work. In August 2019 we searched for peer-reviewed articles in English that were indexed in PubMed, IEEE Xplore, and Springer and published between 2008 and 2019. The keywords included the following phrases: “successful aging at work”, “active aging at work”, “healthy aging at work”, “productive aging at work”, and “older adults at work”. A total of 47,330 publications were found through database searching, and 25,187 publications were screened. Afterwards, 7756 screened publications were excluded from the further analysis, and a total of 17,431 article abstracts were evaluated for inclusion. Finally, further qualitative analysis included 1375 articles, of which about 24 are discussed in this article. The most prominent works suggest policies that encourage life-long learning, and a workforce that comprises both younger and older workers, as well as gradual retirement.
Published: 2020

7. Funding kidney research as a public health priority

Author: Ziad A. Massy, Dimitrios S. Goumenos, Annette Bruchfeld, Ivan Rychlik, Carsten A. Wagner, Hans-Joachim Anders, Tom Oostrom, Carmine Zoccali, Giovambattista Capasso, Ron T. Gansevoort, María José Soler, Kate Stevens, Denis Fouque, Peter J. Blankestijn, Goce Spasovski, Danilo Fliser, Friedo W. Dekker, Kitty J Jager, Mario Cozzolino, Christoph Wanner, Raymond Vanholder, University of Zurich, Universita Mediterranea of Reggio Calabria [Reggio Calabria], Ghent University Hospital, European Kidney Health Alliance (EKHA), University hospital of Zurich [Zurich], Klinikum der Universität [München], University Medical Center [Utrecht], Karolinska University Hospital [Stockholm], University of the Study of Campania Luigi Vanvitelli, University of Milan, Leiden University Medical Center (LUMC), Saarland University [Saarbrücken], Université de la Sarre, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), University Medical Center Groningen [Groningen] (UMCG), General University Hospital of Patras, University of Amsterdam [Amsterdam] (UvA), Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) (U1018 (Équipe 5)), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Dutch Kidney Foundation [Bussum, The Netherlands] (DKF), Charles University [Prague] (CU), Vall d’Hebron Research Institute (VHIR), Queen Elizabeth University Hospital (Glasgow), Ss. Cyril and Methodius University in Skopje, University of Würzburg, CarMeN, laboratoire, Università degli Studi di Milano = University of Milan (UNIMI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Ss. Cyril and Methodius University in Skopje (UKIM)
Subjects: medicine.medical_specialty, kidney, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, 610 Medicine & health, 030204 cardiovascular system & hematology, 10052 Institute of Physiology, 03 medical and health sciences, 0302 clinical medicine, Renal Dialysis, medicine, CKD, Humans, Transplantation, research, Health Priorities, business.industry, Public health, funding, Public relations, medicine.disease, Medical research, 3. Good health, [SDV] Life Sciences [q-bio], Europe, Seed money, Alliance, Framing (social sciences), scientific societies, Nephrology, 570 Life sciences, biology, Public Health, business, Working group, Social responsibility, Kidney disease
Abstract: Medical societies have a social responsibility to disseminate knowledge and inform health authorities on threats to public health posed by various diseases. Advocacy for health protection programmes and for medical research funding is now embedded into the missions of most scientific societies. To promote kidney research funding in Europe, the European Renal Association – European Dialysis and Transplant Association (ERA-EDTA), rather than acting as an individual society advocating for the fight against kidney disease, has actively helped to create an alliance of national associations centred on kidney diseases, the European Kidney Health Alliance (EKHA), and joined the Biomedical Alliance (BMA). The ERA-EDTA is fully committed to supporting its working groups (WGs) and consortia of its members to allow them to produce valuable kidney research. The framing and formalization of projects, and the regulatory issues related to submission to the European Commission, are complex. To help WGs to gain expert advice from agencies with specific know-how, the ERA-EDTA has adopted a competitive approach. The best research projects proposed by WGs and consortia of other European investigators will receive seed funding to cover the costs of consultancy by expert agencies. Via its broader platforms, the EKHA and the BMA, the ERA-EDTA will strive towards broader recognition of kidney disease and related clusters of non-communicable diseases, by European and national agencies, as major threats to the qualities of life of their populations and their economies.
Published: 2022
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8. The Effect of Emotions on Translations Performance

Author: Kimovska, Sonja K., Cvetkoski, Vladimir, Kimovska, Sonja K. - Ss. Cyril and Methodius University in Skopje, Macedonia, Cvetkoski, Vladimir - Ss. Cyril and Methodius University in Skopje, Macedonia, Kimovska, Sonja K. - sonjakitanovska@flf.ukim.edu.mk, and Cvetkoski, Vladimir - cvetkoski@flf.ukim.edu.mk
Subjects: Linguistics and Language, accuracy, feedback, emotions, translation process, resilience, creativity, Language and Linguistics
Abstract: The purpose of this paper is to investigate the effect of emotions and some personality traits on translation performance. It builds on Rojo and Ramos’s (2016) findings and is broadly based on their methodology, but introduces some methodological changes. It replicates their experiment with translation students in another language pair (English L2>Macedonian L1) following their three step procedure: resiliency test, translation-bogus feedback-translation, self-reporting questionnaire. Following their recommendations (ibid.), the change in methodology involves using comparatively easier translation tasks. The paper aims to provide answers as to: the effect of positive and negative emotions on overall translation performance; the effect of positive and negative emotions on different aspects of translation performance (accuracy vs. creativity) and the role of the personality trait of resilience in regulating negative emotions.
Published: 2021
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9. Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae

Author: Daniele Bigi, Fiona Menzi, Slim Ben Jemaa, Marie-Christine Deloche, Aurélien Capitan, Johannes A. Lenstra, Marina Naval-Sanchez, Ivica Medugorac, Nathalie Hirter, Gwenola Tosser-Klopp, Diane Esquerre, Coralie M. Reich, Julia M. Paris, Rose-Marie Arbogast, Amandine Blin, Abdelhak Boukadiri, Aurélie Hintermann, Julie Rivière, Denis Duboule, Raphaël Cornette, Cécile Donnadieu, Marie-Dominique Wandhammer, Gjoko Bunevski, Louisa Gidney, Michael Stache, Isabelle Palhiere, Renate Schafberg, James Kijas, Claude Guintard, Joséphine Lesur, Jozsef Zakany, Rachel Rupp, Noelle E. Cockett, John Hedges, Ashleigh Haruda, Philippe Bardou, Olivier Putelat, Tracy Hadfield, Alain Pinton, Ockert Greyvenstein, Aurélie Allais-Bonnet, Este Van Marle-Koster, Eric Pailhoux, Coralie Danchin-Burge, David G. Riley, Cécile Grohs, Benjamin J. Hayes, Cord Drögemüller, Allice, Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Martin-Luther-University Halle-Wittenberg, Génétique Animale et Biologie Intégrative (GABI), Université Paris-Saclay-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Geneva [Switzerland], University of Bologna, Ludwig Maximilian University [Munich] (LMU), Archéologie d'Alsace, Archéologie et histoire ancienne : Méditerranée - Europe (ARCHIMEDE), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Texas A&M University [College Station], Utah State University (USU), Université de Carthage - University of Carthage, Ss. Cyril and Methodius University in Skopje, University of Bern, Manx Text, Manx Loaghtan Sheep Breeders (MLSBG), Utrecht University [Utrecht], Rent a Peasant, Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Musée Zoologique de Strasbourg, Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Acquisition et Analyse de Données pour l'Histoire naturelle (2AD), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de l'élevage (IDELE), Agriculture Victoria (AgriBio), Tshwane University of Technology [Pretoria] (TUT), Queensland Alliance for Agriculture and Food Innovation (QAAFI), University of Queensland [Brisbane], CSIRO Agriculture and Food (CSIRO), Ecole Polytechnique Fédérale de Lausanne (EPFL), Collège de France (CdF (institution)), Allais-Bonnet, Aurélie, Hintermann, Aurélie, Deloche, Marie-Christine, Cornette, Raphaël, Bardou, Philippe, Naval-Sanchez, Marina, Pinton, Alain, Haruda, Ashleigh, Grohs, Cécile, Zakany, Jozsef, Bigi, Daniele, Medugorac, Ivica, Putelat, Olivier, Greyvenstein, Ockert, Hadfield, Tracy, Jemaa, Slim Ben, Bunevski, Gjoko, Menzi, Fiona, Hirter, Nathalie, Paris, Julia M, Hedges, John, Palhiere, Isabelle, Rupp, Rachel, Lenstra, Johannes A, Gidney, Louisa, Lesur, Joséphine, Schafberg, Renate, Stache, Michael, Wandhammer, Marie-Dominique, Arbogast, Rose-Marie, Guintard, Claude, Blin, Amandine, Boukadiri, Abdelhak, Rivière, Julie, Esquerré, Diane, Donnadieu, Cécile, Danchin-Burge, Coralie, Reich, Coralie M, Riley, David G, Marle-Koster, Este van, Cockett, Noelle, Hayes, Benjamin J, Drögemüller, Cord, Kijas, Jame, Pailhoux, Eric, Tosser-Klopp, Gwenola, Duboule, Deni, Capitan, Aurélien, École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), École nationale vétérinaire - Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Université de Genève = University of Geneva (UNIGE), University of Bologna/Università di Bologna, Ss. Cyril and Methodius University in Skopje (UKIM), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), and Collège de France - Chaire internationale Évolution des génomes et développement
Subjects: 0106 biological sciences, Male, co-option, translocation, AcademicSubjects/SCI01180, regulatory mutation, 01 natural sciences, Hox genes, Hox gene, genes, 610 Medicine & health, Bilateria, time, Horns, 0303 health sciences, biology, Ecology, 630 Agriculture, Goats, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Gene Expression Regulation, Developmental, alignment, Morphogenetic field, Biological Evolution, [SDV.BDD.MOR] Life Sciences [q-bio]/Development Biology/Morphogenesis, 590 Animals (Zoology), Haploinsufficiency, transcription, Biometry, Evolution, growth, Locus (genetics), Mice, Transgenic, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, 010603 evolutionary biology, 03 medical and health sciences, goat and sheep genomics, Behavior and Systematics, framework, Genetics, Animals, Allele, Gene, Molecular Biology, Discoveries, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Homeodomain Proteins, locus, Sheep, Horn (anatomy), AcademicSubjects/SCI01130, [SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis, sequence, biology.organism_classification, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, Evolutionary biology, Mutation, genome-wide association, 570 Life sciences, goat and sheep genomic
Abstract: In the course of evolution, pecorans (i.e., higher ruminants) developed a remarkable diversity of osseous cranial appendages, collectively referred to as “headgear,” which likely share the same origin and genetic basis. However, the nature and function of the genetic determinants underlying their number and position remain elusive. Jacob and other rare populations of sheep and goats are characterized by polyceraty, the presence of more than two horns. Here, we characterize distinct POLYCERATE alleles in each species, both associated with defective HOXD1 function. We show that haploinsufficiency at this locus results in the splitting of horn bud primordia, likely following the abnormal extension of an initial morphogenetic field. These results highlight the key role played by this gene in headgear patterning and illustrate the evolutionary co-option of a gene involved in the early development of bilateria to properly fix the position and number of these distinctive organs of Bovidae.
Published: 2021
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10. The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus Complex (Diptera: Ceratopogonidae) at the European level

Author: Mignotte, Antoine, Garros, Claire, Gardes, Laetitia, Balenghien, Thomas, Duhayon, Maxime, Rakotoarivony, Ignace, Tabourin, Laura, Poujol, Lea, Mathieu, Bruno, Ibanez-Justicia, Adolfo, Deniz, Ahmet, Cvetkovikj, Aleksandar, Purse, Bethan, Ramilo, David W., Stougiou, Despoina, Werner, Doreen, Pudar, Dubravka, Petric, Dusan, Veronesi, Eva, Jacobs, Frans, Kampen, Helge, da Fonseca, Isabel Pereira, Lucientes, Javier, Navarro, Javier, de la Puente, Josue Martinez, Stefanovska, Jovana, Searle, Kate R., Khallaayoune, Khalid, Culverwell, C. Lorna, Larska, Magdalena, Bourquia, Maria, Goffredo, Maria, Bisia, Marina, England, Marion, Robin, Matthew, Quaglia, Michela, Miranda-Chueca, Miguel Angel, Bodker, Rene, Estrada-Pena, Rosa, Carpenter, Simon, Tchakarova, Simona, Boutsini, Sofia, Sviland, Stale, Schafer, Stefanie M., Ozolina, Zanda, Seglina, Zanda, Vatansever, Zati, Huber, Karine, Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Agronomique et Vétérinaire Hassan II - IAV (MOROCCO) (IAV), Dynamique des interactions hôte pathogène (DIHP), Université de Strasbourg (UNISTRA), Netherlands Food and Consumer Product Safety Authority (NVWA), Veterinary Control Central Research Institute, Sts. Cyril and Methodius University, Centre for Ecology and Hydrology [Wallingford] (CEH), Natural Environment Research Council (NERC), CIISA-Centro Investigação Interdisciplinar em Sanidade Animal (CIISA), Veterinary Centre of Athens, Leibniz-Zentrum für Agrarlandschaftsforschung = Leibniz Centre for Agricultural Landscape Research (ZALF), University of Novi Sad, Institute of Parasitology, Universität Zürich [Zürich] = University of Zurich (UZH), Friedrich-Loeffler-Institut (FLI), Instituto Agroalimentario de Aragón (IA2), Laboratorio de Producción y Sanidad Animal de Granada, CIBER de Epidemiología y Salud Pública (CIBERESP), Ss. Cyril and Methodius University in Skopje, Centre for Ecology and Hydrology [Edinburgh] (CEH), Unité Parasitologie et Maladies Parasitaires, Institut Agronomique et Vétérinaire Hassan II (IAV), University of Helsinki, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise Guiseppe Caporale (IZSAM), Partenaires INRAE, Institute for Animal Health, the Pirbright Institute, Institute of Infection and Global Health [University of Liverpool, UK], University of Liverpool, University of the Balearic Islands (UIB), University of Copenhagen = Københavns Universitet (KU), National Diagnostic and Research Veterinary Medical Institute, Norwegian Veterinary Institute [Oslo], Institute of Food safety, Faculty of Veterinary Medicine, Department of Parasitology, Kafkas University, his study was partially funded by the EU grant H2020-727393 PALE-Blu and by the VectorNet project (OC/EFSA/AHAW/2013/02-FWC1) funded by the European Centre for Disease Prevention and Control (ECDC) and the European Food Safety Authority (EFSA), European Project: 727393,PALE Blu, Institut Agronomique et Vétérinaire Hassan II (IAV Hassan II), University of Zaragoza - Universidad de Zaragoza [Zaragoza]-Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA), Ss. Cyril and Methodius University in Skopje (UKIM), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, The Pirbright Institute, Biotechnology and Biological Sciences Research Council (BBSRC), University of Copenhagen = Københavns Universitet (UCPH), European Project: 727393,H2020,H2020-EU.3.2.1.1.,PALE-Blu(2017), HUSLAB, Viral Zoonosis Research Unit, Department of Virology, and Medicum
Subjects: Livestock, PCR ASSAYS, Ceratopogonidae, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, lcsh:Infectious and parasitic diseases, Biting midge, RELATIVE-ABUNDANCE, Species delimitation, Animals, DNA Barcoding, Taxonomic, lcsh:RC109-216, CULICOIDES-SCOTICUS DIPTERA, RATES, Phylogeny, Taxonomy, POTENTIAL VECTORS, Geography, GENE TREES, Research, Genetic Variation, BLUETONGUE VIRUS, Sequence Analysis, DNA, LOCUS SPECIES DELIMITATION, Biting midges, Palaearctic Region, Insect Vectors, Europe, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, Biology and Microbiology, DISCRIMINATION, 3121 General medicine, internal medicine and other clinical medicine, Cryptic species, Cyclooxygenase 1, Culicoides spp, Female, 3111 Biomedicine, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract: cet article a fait l’objet d’une correctionDOI : 10.1186/s13071-020-04349-y; International audience; ackgroundCulicoides obsoletus is an abundant and widely distributed Holarctic biting midge species, involved in the transmission of bluetongue virus (BTV) and Schmallenberg virus (SBV) to wild and domestic ruminants. Females of this vector species are often reported jointly with two morphologically very close species, C. scoticus and C. montanus, forming the Obsoletus/Scoticus Complex. Recently, cryptic diversity within C. obsoletus was reported in geographically distant sites. Clear delineation of species and characterization of genetic variability is mandatory to revise their taxonomic status and assess the vector role of each taxonomic entity. Our objectives were to characterize and map the cryptic diversity within the Obsoletus/Scoticus Complex.MethodsPortion of the cox1 mitochondrial gene of 3763 individuals belonging to the Obsoletus/Scoticus Complex was sequenced. Populations from 20 countries along a Palaearctic Mediterranean transect covering Scandinavia to Canary islands (North to South) and Canary islands to Turkey (West to East) were included. Genetic diversity based on cox1 barcoding was supported by 16S rDNA mitochondrial gene sequences and a gene coding for ribosomal 28S rDNA. Species delimitation using a multi-marker methodology was used to revise the current taxonomic scheme of the Obsoletus/Scoticus Complex.ResultsOur analysis showed the existence of three phylogenetic clades (C. obsoletus clade O2, C. obsoletus clade dark and one not yet named and identified) within C. obsoletus. These analyses also revealed two intra-specific clades within C. scoticus and raised questions about the taxonomic status of C. montanus.ConclusionsTo our knowledge, our study provides the first genetic characterization of the Obsoletus/Scoticus Complex on a large geographical scale and allows a revision of the current taxonomic classification for an important group of vector species of livestock viruses in the Palaearctic region.
Published: 2020
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11. When Evolutionary Computing Meets Astro- and Geoinformatics

Author: Miroslav Mirchev, Zaineb Chelly Dagdia, Speech Modeling for Facilitating Oral-Based Communication (MULTISPEECH), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Natural Language Processing & Knowledge Discovery (LORIA - NLPKD), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut Supérieur de Gestion de Tunis [Tunis] (ISG), Université de Tunis, Ss. Cyril and Methodius University in Skopje (UKIM), This work is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 702527., Ss. Cyril and Methodius University in Skopje, Chelly Dagdia, Zaineb, Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
Subjects: Computer science, Computer Science::Neural and Evolutionary Computation, Evolutionary algorithm, Genetic programming, 02 engineering and technology, Evolutionary computation, Metaheuristics, [INFO] Computer Science [cs], 01 natural sciences, Swarm intelligence, [SDU] Sciences of the Universe [physics], 0103 physical sciences, Geoinformatics, 0202 electrical engineering, electronic engineering, information engineering, [INFO.INFO-DC] Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], [INFO]Computer Science [cs], 010303 astronomy & astrophysics, Metaheuristic, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Astroinformatics, Artificial immune system, business.industry, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDU]Sciences of the Universe [physics], 020201 artificial intelligence & image processing, Bio-inspired computing, Artificial intelligence, [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], Evolution strategy, business, [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: International audience; Knowledge discovery from data typically includes solving some type of an optimization problem that can be efficiently addressed using algorithms belonging to the class of evolutionary and bio-inspired computation. In this chapter, we give an overview of the various kinds of evolutionary algorithms, such as genetic algorithms, evolutionary strategy, evolutionary and genetic programming, differential evolution, and coevolutionary algorithms, as well as several other bio-inspired approaches, like swarm intelligence and artificial immune systems. After elaborating on the methodology, we provide numerous examples of applications in astronomy and geoscience and show how these algorithms can be applied within a distributed environment, by making use of parallel computing, which is essential when dealing with Big Data.
Published: 2020

12. Deep drilling reveals massive shifts in evolutionary dynamics after formation of ancient ecosystem

Author: Wilke, Thomas, Hauffe, Torsten, Jovanovska, Elena, Cvetkoska, Aleksandra, Donders, Timme, Ekschmitt, Klemens, Francke, Alexander, Lacey, Jack H., Levkov, Zlatko, Marshall, Charles R., Neubauer, Thomas A., Silvestro, Daniele, Stelbrink, Björn, Vogel, Hendrik, Albrecht, Christian, Holtvoeth, Jens, Krastel, Sebastian, Leicher, Niklas, Leng, Melanie J., Lindhorst, Katja, Masi, Alessia, Ognjanova-Rumenova, Nadja, Panagiotopoulos, Konstantinos, Reed, Jane M., Sadori, Laura, Tofilovska, Slavica, Van Bocxlaer, Bert, Wagner-Cremer, Friederike, Wesselingh, Frank P., Wolters, Volkmar, Zanchetta, Giovanni, Zhang, Xiaosen, Wagner, Bernd, Aquatic Ecology (AqE), Justus-Liebig-Universität Gießen (JLU), Netherlands Institute of Ecology - NIOO-KNAW (NETHERLANDS), Utrecht University [Utrecht], School of Earth and Environmental Sciences [University of Wollongong], University of Wollongong [Australia], British Geological Survey (BGS), Ss. Cyril and Methodius University in Skopje, University of California [Berkeley], University of California, University of Gothenburg (GU), University of Bern, University of Bristol [Bristol], Christian-Albrechts-Universität zu Kiel (CAU), University of Cologne, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Bulgarian Academy of Sciences (BAS), University of Hull [United Kingdom], Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Naturalis Biodiversity Center [Leiden], University of Pisa - Università di Pisa, Shanxi University - Taiyuan, Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Ss. Cyril and Methodius University in Skopje (UKIM), University of California [Berkeley] (UC Berkeley), University of California (UC), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo (EEP)), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Palaeo-ecologie, Coastal dynamics, Fluvial systems and Global change, Stratigraphy and paleontology, and Seismology
Subjects: Fossils, Climate Change, [SDE.MCG]Environmental Sciences/Global Changes, SciAdv r-articles, Paleontology, Biodiversity, 580 Plants (Botany), Biological Evolution, Plan_S-Compliant-OA, Climate Action, Lakes, 560 Fossils & prehistoric life, deep drilling, evolutionary dynamics, lake Ohrid, international, 570 Life sciences, biology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, General, [SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/Paleontology, Research Articles, Ecosystem, 550 Earth sciences & geology, Research Article
Abstract: A volatile assemblage of short-lived endemic species developed into a stable community of long-lived species in Lake Ohrid., The scarcity of high-resolution empirical data directly tracking diversity over time limits our understanding of speciation and extinction dynamics and the drivers of rate changes. Here, we analyze a continuous species-level fossil record of endemic diatoms from ancient Lake Ohrid, along with environmental and climate indicator time series since lake formation 1.36 million years (Ma) ago. We show that speciation and extinction rates nearly simultaneously decreased in the environmentally dynamic phase after ecosystem formation and stabilized after deep-water conditions established in Lake Ohrid. As the lake deepens, we also see a switch in the macroevolutionary trade-off, resulting in a transition from a volatile assemblage of short-lived endemic species to a stable community of long-lived species. Our results emphasize the importance of the interplay between environmental/climate change, ecosystem stability, and environmental limits to diversity for diversification processes. The study also provides a new understanding of evolutionary dynamics in long-lived ecosystems.
Published: 2020
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13. Multiscale in modelling and validation for solar photovoltaics

Author: Witold Jacak, Emmanuel Stratakis, J. C. Rimada, Hele Savin, Efrat Lifshitz, Mimoza Ristova, Mateja Hočevar, Radovan Kopecek, Blas Garrido, M. J. M. Gomes, Mircea Guina, Konstantinos Petridis, Alessio Gagliardi, David Fuertes Marrón, Ivana Capan, Jacky Even, Jaroslav Zadny, Pavel Tománek, V. Donchev, Stefan Birner, Janne Halme, Zoe Amin-Akhlaghi, Fatma Yuksel, Frederic Cortes Juan, Ahmed Neijm, Lejo k. Joseph, Søren Madsen, Abdurrahman Şengül, Marija Drev, Kristian Berland, Jose G. F. Coutinho, Knut Deppert, Diego Alonso-Álvarez, José Silva, Lucjan Jacak, Georg Pucker, Marco Califano, Violetta Gianneta, Nicholas J. Ekins-Daukes, Nikola Bednar, Urs Aeberhard, Shuxia Tao, Spyridon Kassavetis, Rasit Turan, Jelena Radovanović, Katarzyna Kluczyk, Ullrich Steiner, Ivana Savic, Maria E. Messing, Victor Neto, Stanko Tomić, Neil Beattie, Shengda Wang, Androula G. Nassiopoulou, Antonio Martí Vega, Denis Mencaraglia, M. Sendova-Vassileva, Ákos Nemcsics, Felipe Murphy Armando, Boukje Ehlen, Jean-François Guillemoles, Matthias Auf der Maur, James P. Connolly, Laurent Pedesseau, Clas Persson, Christin David, Lacramioara Popescu, Bostjan Cerne, N. Adamovic, Jean-Louis Lazzari, JM José Maria Ulloa, Urša Opara Krašovec, Irinela Chilibon, Jan Storch, Zoran Jakšić, Antti Tukiainen, Tareq Abu Hamed, Martin Loncaric, Laurentiu Fara, V. Kazukauskas, Jean-Paul Kleider, Javad Zarbakhsh, Dead Sea-Arava Science Center (DSASC), Institut für Energie- und Klimaforschung - Photovoltaik (IEK-5), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Imperial College London, ZAMSTEC − Science, Technology and Engineering Consulting, Università degli Studi di Roma Tor Vergata [Roma], University of Northumbria at Newcastle [United Kingdom], University of Leeds, Rudjer Boskovic Institute [Zagreb], Laboratoire Génie électrique et électronique de Paris (GeePs), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de València (UPV), Lund University [Lund], Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), University Politehnica of Bucharest [Romania] (UPB), Universidad Politécnica de Madrid (UPM), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), National Center for Scientific Research 'Demokritos' (NCSR), Centre of Physics of the University of Minho (CFUM), Institut de Recherche et Développement sur l'Energie Photovoltaïque (IRDEP), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Tampere University of Technology [Tampere] (TUT), Aalto University, University of Ljubljana, Wroclaw University of Science and Technology, University of Belgrade [Belgrade], Aristotle University of Thessaloniki, Vilnius University [Vilnius], Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aarhus University [Aarhus], University College Cork (UCC), Óbuda University [Budapest], Universidade de Aveiro, University of Oslo (UiO), Technological Educational Institute of Crete, Fondazione Bruno Kessler [Trento, Italy] (FBK), University of Havana (Universidad de la Habana) (UH), Ss. Cyril and Methodius University in Skopje (UKIM), Tyndall National Institute [Cork], Zonguldak Bülent Ecevit University (BEU), Universidade de Taubaté (UNITAU), Cavendish Laboratory, University of Cambridge [UK] (CAM), Institute of Chemical Process Fundamentals of the ASCR, Czech Republic, Foundation for Research and Technology - Hellas (FORTH), Eindhoven University of Technology [Eindhoven] (TU/e), Brno University of Technology [Brno] (BUT), University of Salford, Middle East Technical University [Ankara] (METU), Gebze Technical University, Czech Academy of Sciences [Prague] (CAS), Carinthia University of Applied Sciences, MP1406, European Cooperation in Science and Technology, Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ss. Cyril and Methodius University in Skopje, Universidade do Minho, Dead Sea and Arava Science Center, Vienna University of Technology, Forschungszentrum Jülich, University of Rome Tor Vergata, Northumbria University, University of Oslo, nextnano GmbH, Rudjer Boskovic Institute, ZEL-EN d.o.o., National Institute of Research and Development for Optoelectronics, Université Paris-Saclay, Polytechnic University of Valencia, University of Aveiro, Madrid Institute for Advanced Studies in Nanoscience, Lund University, Sofia University St. Kliment Ohridski, Trimo Grp, Boukje.com Consulting, Centre National de la Recherche Scientifique (CNRS), University Politehnica of Bucharest, Technical University of Munich, University of Barcelona, Institute of Nanoscience and Nanotechnology, The University of Tokyo, Tampere University of Technology, Department of Applied Physics, Wrocław University of Science and Technology, University of Belgrade, ISC Konstanz eV, Vilnius University, Aix-Marseille Université, Technion-Israel Institute of Technology, Aarhus University, Polytechnic University of Madrid, University College Cork, Demokritos National Centre for Scientific Research, Silvaco Europe Ltd, Óbuda University, Hellenic Mediterranean University, Fondazione Bruno Kessler, University of Havana, SS Cyril and Methodius University in Skopje, Department of Electronics and Nanoengineering, Bulgarian Academy of Sciences, Bulent Ecevit University, Adolphe Merkle Institute, Czech Academy of Sciences, Foundation for Research and Technology - Hellas, Eindhoven University of Technology, Brno University of Technology, Middle East Technical University, Aalto-yliopisto, Zonguldak Bülent Ecevit Üniversitesi, Center for Computational Energy Research, and Computational Materials Physics
Subjects: Nano structures, lcsh:TJ807-830, Modelling and validation, 02 engineering and technology, semiconductors, 01 natural sciences, 7. Clean energy, Settore ING-INF/01 - Elettronica, Environmental footprints, law.invention, [SPI.MAT]Engineering Sciences [physics]/Materials, Semiconductor materials, WAVE BASIS-SET, law, Photovoltaics, CARRIER MULTIPLICATION, Multi-scale simulation, multi-scale modelling, Telecomunicaciones, COLLOIDAL QUANTUM DOTS, device simulation, NANOMETER-SCALE, Photovoltaic cells, Physics, Photovoltaic system, Nanostructured materials, Renewable energy resources, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Multiscale modeling, Electronic, Optical and Magnetic Materials, Characterization (materials science), Renewable energy, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, ELECTRONIC-STRUCTURE, SDG 12 – Verantwoordelijke consumptie en productie, Energías Renovables, Physical Sciences, TIGHT-BINDING, Systems engineering, Electrónica, 0210 nano-technology, NEAR-FIELD, solar cells, third generation photovoltaics, nano structures, Solar cells, J500, Ciências Naturais::Ciências Físicas, F300, H600, Third generation photovoltaics, ta221, Renewable energy source, Ciências Físicas [Ciências Naturais], lcsh:Renewable energy sources, GREENS-FUNCTION, Solar power generation, Different length scale, Physics, Applied, OPTICAL-RESPONSE, 0103 physical sciences, Solar cell, SDG 7 - Affordable and Clean Energy, Electrical and Electronic Engineering, 010306 general physics, Device simulations, Ecological footprint, Science & Technology, ta114, Renewable Energy, Sustainability and the Environment, business.industry, TOTAL-ENERGY CALCULATIONS, [SPI.NRJ]Engineering Sciences [physics]/Electric power, Environmental technology, Nanostructures, Multiple exciton generation, 13. Climate action, Conversion efficiency, business, SDG 12 - Responsible Consumption and Production, SDG 7 – Betaalbare en schone energie
Abstract: Photovoltaics is amongst the most important technologies for renewable energy sources, and plays a key role in the development of a society with a smaller environmental footprint. Key parameters for solar cells are their energy conversion efficiency, their operating lifetime, and the cost of the energy obtained from a photovoltaic system compared to other sources. The optimization of these aspects involves the exploitation of new materials and development of novel solar cell concepts and designs. Both theoretical modeling and characterization of such devices require a comprehensive view including all scales from the atomic to the macroscopic and industrial scale. The different length scales of the electronic and optical degrees of freedoms specifically lead to an intrinsic need for multiscale simulation, which is accentuated in many advanced photovoltaics concepts including nanostructured regions. Therefore, multiscale modeling has found particular interest in the photovoltaics community, as a tool to advance the field beyond its current limits. In this article, we review the field of multiscale techniques applied to photovoltaics, and we discuss opportunities and remaining challenges. © T. Abu Hamed et al., published by EDP Sciences, 2018., European Cooperation in Science and Technology: MP1406, The authors are grateful for the financial support by the COST Action MP1406 “MultiscaleSolar.”
Published: 2018
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14. The significance of scope in modelling tones in Chinese

Author: Branislav Gerazov, Gérard Bailly, Yi Xu, Ss. Cyril and Methodius University in Skopje, GIPSA - Cognitive Robotics, Interactive Systems, & Speech Processing (GIPSA-CRISSP), Département Parole et Cognition (GIPSA-DPC), Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University College of London [London] (UCL), H2020 Marie-Curie Prosodeep, European Project: 745802,Prosodeep, and Ss. Cyril and Methodius University in Skopje (UKIM)
Subjects: Chinese, Scope (project management), SFC, Computer science, Speech recognition, Intonation (linguistics), Tone (linguistics), Contrast (statistics), intonation, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Duration (music), Line (geometry), tones, Chinese, scope, pitch, intonation, SFC, Index Terms: tones, scope, Syllable, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, Prosody, pitch
Abstract: International audience; The Superposition of Functional Contours (SFC) prosody model decomposes the intonation and duration contours into elementary contours that encode specific linguistic functions. It can be used to extract these functional contours at multiple linguistic levels. The PySFC system, which incorporates the SFC, can thus be used to analyse the significance of including the neighbouring syllables in the scope of the tone functional contours in spoken Chinese on the modelling of prosody. Our results show that significant improvements of modelling tone functional contours are obtained by including the right syllable in the scope, but not the left one. We thus show that there is a larger carry-over effect for Chinese tones in contrast to an anticipatory one. This finding is in line with the established state-of-the-art.
Published: 2018
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15. Last deglaciation in the central Balkan Peninsula: Geochronological evidence from the Jablanica Mt. (North Macedonia)

Author: Zoltán Kern, Marjan Temovski, Régis Braucher, Zsófia Ruszkiczay-Rüdiger, Balázs Madarász, Ivica Milevski, Institute for Geological and Geochemical Research, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Geographical Institute of Research, Ss. Cyril and Methodius University in Skopje (UKIM), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), National Research, Development and Innovation Office of HungaryOTKA FK 124807European CommissionState of Hungary - European Regional Development FundGINOP-2.3.2-15-2016-00009Centre National de la Recherche Scientifique (CNRS)French National Research Agency (ANR)IRD, Ss. Cyril and Methodius University in Skopje, and Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)
Subjects: Paleoclimate, 010504 meteorology & atmospheric sciences, Pleistocene, [SDE.MCG]Environmental Sciences/Global Changes, Glacial landform, Mediterranean, 010502 geochemistry & geophysics, Glacial geomorphology, 01 natural sciences, Cosmogenic nuclide, Paleoclimatology, Deglaciation, [SDU.STU.GL]Sciences of the Universe [physics]/Earth Sciences/Glaciology, [SDU.STU.GM]Sciences of the Universe [physics]/Earth Sciences/Geomorphology, Younger Dryas, Glacial period, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Earth-Surface Processes, [SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics, geography, geography.geographical_feature_category, Glacier, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, 13. Climate action, Physical geography, Geology
Abstract: International audience; Several studies applied numerical age determination methods to examine glacial phases of the central Balkan Peninsula. However, the resulting datasets are contradictory, meaning that further discussion is needed. This study provides 10 Be cosmic ray exposure (CRE) ages of a succession of glacial landforms in the Jablanica Mt. (North Macedonia), aiming at a better understanding of Late Pleistocene glacier development in the area. On the basis of the mapped glacial landforms, six glacial stages were identified and their mean equilibrium line altitudes (ELAs) were estimated. The CRE ages of five glacial stages-from the second oldest to the youngest-were determined between 16.8 +0.8 / −0.5 ka and 13.0 +0.4 / −0.9 ka. Accordingly, the most extensive glaciation in the Jablanica Mt. occurred before~17 ka. The average ELA of the glaciers was 1792 ± 18 m a.s.l. during the largest ice extent, and 2096 ± 18 m during the last phase of the deglaciation. Independent reconstructions of key climatic drivers of glaciological mass balance suggest that glacial re-advances during the deglaciation were associated to cool summer temperatures before~15 ka. The last glacial stillstand apparently resulted from a modest drop in summer temperature coupled with increased winter snow accumulation. In the study area no geomorphological evidence for glacier advance after~13 +0.4 / −0.9 ka could be found. On the basis of independent climate proxies we propose that the last glacier advance occurred no later thañ 13 ka, and glaciers were withdrawing during the Younger Dryas when low temperatures were combined with dry winters.
Published: 2020
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16. The Expanding Menagerie of Prunus-Infecting Luteoviruses

Author: Maryam Khalili, Thierry Candresse, Igor Koloniuk, Dana Safarova, Yoann Brans, Chantal Faure, Marine Delmas, Sébastien Massart, Miguel A. Aranda, Kadriye Caglayan, Veronique Decroocq, Pavlina Drogoudi, Miroslav Glasa, George Pantelidis, Milan Navratil, François Latour, Josef Spak, Jaroslava Pribylova, Daniel Mihalik, Francesco Palmisano, Antonella Saponari, Tomas Necas, Jiri Sedlak, Armelle Marais, Biologie du fruit et pathologie (BFP), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute of Plant Molecular Biology, Biological Centre, Czech Academy of Sciences [Prague] (CAS), Palacky University Olomouc, Centre Technique Interprofessionnel des Fruits et Légumes (CTIFL), Unité Expérimentale Arboricole (UE ARBO), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), TERRA, Gembloux Agro-Bio Tech, Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Hatay Mustafa Kemal University, Ellinikos Georgikos OrGanismos-DIMITRA (ELGO -DIMITRA), Slovak Academy of Science [Bratislava] (SAS), Institute of Biology, Ss Cyril and Methodius University in Skopje, Agricultural Research and Experimentation Centre 'Basile Caramia', Mendel University in Brno (MENDELU), Vyzkumny A Slechtitelsky Ustav Ovocnarsky, This study was funded by the European Union through the Horizon 2020 Marie Skłodowska-Curie Actions Innovative Training Network (H2020 MSCA- 60 ITN) project 'INEXTVIR' (Grant agreement number 813542). The ChLVA research part was financed by Academy of Sciences of the Czech Republic support (RVO60077344). The plant indexing biological tests conducted by CTIFL were funded by INTERFEL (Fresh fruit and 68vegetable interprofessional association). D. Safarova and M. Navratil have received support from the Ministry of Agriculture of the Czech Republic, National Agency for Agricultural Research (Project no. QK1920124). M. Glasa and D. Mihálik have received support from the Slovak Research & Development Agency (project APVV-18-0005), European Project: H2020 MSCA-60 ITN, and European Project: 813542,INEXTVIR
Subjects: biological indexing, Stone fruit, [SDV]Life Sciences [q-bio], Luteovirus, geographical distribution, HTS, Plant Science, Pathogen Detection, Agronomy and Crop Science, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy
Abstract: International audience; Members of the genus Luteovirus are responsible for economically destructive plant diseases worldwide. Over the past few years, three luteoviruses infecting Prunus trees have been characterized. However, the biological properties, prevalence, and genetic diversity of those viruses have not yet been studied. High throughput sequencing of samples of various wild, cultivated, and ornamental Prunus species enabled the identification of four novel species in the genus Luteovirus for which we obtained complete or nearly complete genomes. Besides, we identified another new putative species recovered from Sequence Read Archive data. Furthermore, we conducted a survey on peach-infecting luteoviruses in eight European countries. Analyses of 350 leaf samples collected from germplasm, production orchards, and private gardens showed that peach-associated luteovirus (PaLV), nectarine stem pitting-associated virus (NSPaV), and a novel luteovirus, peach-associated luteovirus 2 (PaLV2), are present in all countries, while the most prevalent virus was NSPaV, followed by PaLV. An analysis of the genetic diversity of these viruses was also conducted. Moreover, the biological indexing on GF305 peach indicator plants demonstrated that PaLV and PaLV2, like NSPaV, are transmitted by graft at relatively low rates. No clear viral symptoms have been observed either in graft-inoculated GF305 indicators, or in different peach tree varieties observed in an orchard. The data generated during this study provide a broader overview of the genetic diversity, geographical distribution and prevalence of peach-infecting luteoviruses, and suggest these viruses are likely asymptomatic in peach under most circumstances.
Published: 2023
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17. Essential Thrombocythemia Associated With Germline JAK2 G571S Variant and Somatic CALR Type 1 Mutation

Author: Lidija Cevreska, Martin Ivanovski, Aleksandar Eftimov, Sylvie Hermouet, Aleksandra Pivkova-Veljanovska, Aleksandar Dimovski, Irina Panovska-Stavridis, University of Clinic of Hematology, St. Cyril and St. Methodius University in Skopje, Center for Biomolecular Pharmaceutical Analyses, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), This work was supported by MPN & MPNr-EuroNet (ex-COST Action BM0902) and research funds from the Center forBiomolecular Pharmaceutical Analysis, UKIM-Faculty of Pharmacy,Skopje, Republic of Macedonia., Bernardo, Elizabeth, and Ss. Cyril and Methodius University in Skopje (UKIM)
Subjects: 0301 basic medicine, Male, Cancer Research, DNA Mutational Analysis, Germline, Myeloproliferative neoplasms, 0302 clinical medicine, Germ line, hemic and lymphatic diseases, Genotype, Genetics, Aged, 80 and over, biology, Hematology, Middle Aged, Phenotype, 3. Good health, Pedigree, Oncology, 030220 oncology & carcinogenesis, Mutation (genetic algorithm), Female, Thrombocythemia, Essential, Thrombocythosis, Adult, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Germline mutation, [SDV.CAN] Life Sciences [q-bio]/Cancer, medicine, Humans, JAK2 mutation, Codon, Germ-Line Mutation, Thrombocytosis, Essential thrombocythemia, business.industry, Janus Kinase 2, medicine.disease, CALR pK385fs*47 mutation, 030104 developmental biology, Amino Acid Substitution, Mutation, biology.protein, business, Calreticulin, Biomarkers
Abstract: International audience; In this study, we report on a family with a germline JAK2 G571S mutation with only one individual presenting with thrombocytosis, who also had a somatic CALR mutation (insertion p.K385fs*47). Our results highlight the complexity of the diagnosis of chronic thrombocytosis, and confirm that genetic alterations in the JAK2 and CALR genes are not always mutually exclusive, nor always responsible for disease phenotype. Our findings suggest that, in routine clinical practice, the diagnostic workup of patients with thrombocytosis should include the simultaneous investigation of JAK2, CALR, and MPL mutations (ie, should not stop once a mutation is identified in the JAK2 gene).
Published: 2016
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18. The DESCARTES-Nantes survey of kidney transplant recipients displaying clinical operational tolerance identifies 35 new tolerant patients and 34 almost tolerant patients

Author: Michaela Prokopova, Friedrich Thaiss, Andries J. Hoitsma, Bruno Hurault de Ligny, Anja Mühlfeld, Séverine Martin, Oliver Gross, Władysław Sułowicz, Annick Massart, Judith Racapé, Miguel Angel Gentil Govantes, A. Yussim, Frieder Keller, Umberto Maggiore, Matthew Howse, Gian Benedetto Piredda, Ricardo Lauzurica, Magali Giral, Luis Antonio Jiménez del Cerro, Marie-Christine Moal, Tomas Reischig, François Glowacki, Jean-François Subra, Bénédicte Janbon, Consuelo De Biase, María José Pérez-Sáez, Marian Klinger, Goce Spasovski, Philippe Gatault, Gaetano La Manna, David Berglund, Cem Tugmen, Giovanni M. Frascà, Uyen Huynh-Do, Christophe Legendre, Annaïck Pallier, Christopher Dudley, Mélanie Chesneau, Laura Braun, Daniel Abramowicz, Karine Hadaya, Christian Noel, Evangeline Pillebout, Carmen Díaz-Corte, Julio Pascual, Ondrej Viklicky, Florence Villemain, Luigi Biancone, Ana Ramírez Puga, Marije C. Baas, Alain Le Moine, Marc Abramowicz, Frederike J. Bemelman, Rainer Oberbauer, Jean-Paul Soulillou, Nurhan Seyahi, Jadranka Buturović Ponikvar, Johan W. de Fijter, Maarten Naesens, Vania Cuna, Klemens Budde, Serhan Tuglular, Pierrick Guerif, Angel Alonso Hernandez, Piero Stratta, Arnaud Garnier, Hulya Colak, K. Clemente, Sophie Brouard, Marc Hazzan, Søren Schwartz Sørensen, Giuseppe Orlando, Daniel Serón, Luboslav Beňa, Quirino Lai, Francesco Pisani, Aisling E. Courtney, Alexandre Dufay, Mehmet Sukru Sever, Thomas Wekerle, Hervé Le Monies De Sagazan, Hakim Mazouz, Aljoša Kandus, Maria Carmen Cantarell, André Gaasbeek, Massart, A, Pallier, A, Pascual, J, Viklicky, O, Budde, K, Spasovski, G, Klinger ,M, Sever, MS, Sørensen, SS, Hadaya, K, Oberbauer, R, Dudley, C, De Fijter, JW, Yussim, A, Hazzan, M, Wekerle, T, Berglund, D, De Biase, C, Pérez-Sáez, MJ, Mühlfeld, A, Orlando, G, Clemente, K, Lai, Q, Pisani, F, Kandus, A, Baas, M, Bemelman, F, Ponikvar, JB, Mazouz ,H, Stratta, P, Subra, JF, Villemain, F, Hoitsma, A, Braun, L, Cantarell, MC, Colak, H, Courtney, A, Frasca, GM, Howse, M, Naesens, M, Reischig, T, Serón, D, Seyahi, N, Tugmen, C, Alonso Hernandez, A, Beňa, L, Biancone, L, Cuna, V, Díaz-Corte, C, Dufay, A, Gaasbeek, A, Garnier, A, Gatault, P, Gentil Govantes, MA, Glowacki, F, Gross, O, Hurault de Ligny, B, Huynh-Do, U, Janbon, B, Jiménez Del Cerro, LA, Keller, F, La Manna, Gaetano, Lauzurica, R, Le Monies De Sagazan, H, Thaiss, F, Legendre, C, Martin, S, Moal, MC, Noël, C, Pillebout, E, Piredda, GB, Puga, AR, Sulowicz, W, Tuglular, S, Prokopova, M, Chesneau, M, Le Moine, A, Guérif, P, Soulillou, JP, Abramowicz, M, Giral, M, Racapé, J, Maggiore, U, Brouard, S, Abramowicz, D, AII - Amsterdam institute for Infection and Immunity, Nephrology, Renal Unit [Brussels, Belgium] (ULB), Université libre de Bruxelles (ULB)-CUB Hôpital Erasme [Bruxelles, Belgium], Medical Genetics Department [Brussels, Belgium], Université libre de Bruxelles (ULB), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Nephrology [Barcelona, Spain] (Hospital del Mar), Hospital del Mar [Barcelona, Spain], Department of Nephrology [Prague, Czech Republic] (Transplant Center), Institute for Clinical and Experimental Medicine (IKEM), Department of Nephrology [Berlin, Germany], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Nephrology [Skopje, Macedonia], Ss. Cyril and Methodius University in Skopje, Nephrology and Transplantation Medicine [Wrocław, Poland], University of Wrocław [Poland] (UWr), Internal Medicine, Nephrology [Istanbul, Turkey], Istanbul School of Medicine [Istanbul, Turkey], Nephrology P [Copenhagen, Denmark], Rigshospitalet [Copenhagen], Copenhagen University Hospital-Copenhagen University Hospital, Nephrology and Transplantation [Geneva, Switzerland], Geneva University Hospitals - HUG [Switzerland], Department of Medicine III–Nephrology, Hypertension and Renal Transplantation [Linz, Austria], Krankenhaus Elisabethinen Linz [Linz, Austria], Richard Bright Renal Centre [Bristol, UK], Southmead Hospital [Bristol, UK]-North Bristol NHS Trust [Bristol, UK], Department of Nephrology [Leiden, The Netherlands], Leiden University Medical Center (LUMC), Department of Transplantation [Tel Aviv, Israël] (Rabin Medical Center), Rabin Medical Center [Tel Aviv, Israël]-Tel Aviv University Sackler School of Medicine [Tel Aviv, Israël], Département de Néphrologie [CHRU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of Surgery [Vienna, Austria] (Section of Transplantation Immunology), Medizinische Universität Wien = Medical University of Vienna, Section of Clinical Immunology [Uppsala, Sweden] (Department of Immunology, Genetics and Pathology), Uppsala University, UOS Trapianti Rene Pancreas [Parma, Italy] (Centro Trapianti di Parma), Azienda Ospedaliero-Universitaria di Parma, Department of Nephrology [Aachen, Germany], University Hospital Aachen, Section of Transplantation [Winston-Salem, NC, USA] (Department of Surgery), Wake Forest School of Medicine [Winston-Salem], Wake Forest Baptist Medical Center-Wake Forest Baptist Medical Center, U.O.C. Trapianti D’Organo [L’Aquila, Italy], Department of Nephrology [Ljubljana, Slovenia] (Renal Transplantation Centre Ljubljana), University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Kidney Diseases [Nijmegen, The Netherlands], Radboudumc Nijmegen [The Netherlands], Renal Transplant Unit [Amsterdam, The Netherlands] (Department of Nephrology), Academic Medical Center [Amsterdam, Netherlands], Unité de Transplantation Rénale et Pancréatique [CHU Sud, Amiens] (Service de Néphrologie), CHU Amiens-Picardie, Department of Translational Medicine [Novara, Italy], Amedeo Avogadro University of Eastern Piedmont, Service de Néphrologie-Dialyse-Transplantation [Angers], Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), service de Néphrologie et Transplantation Rénale [CHU Strasbourg] (Hôpital de jour de Néphrologie), Centre Hospitalier Universitaire de Strasbourg (CHU de Strasbourg )-Nouvel Hôpital Civil - NHC [Strasbourg], Pediatric Nephrology [Barcelona, Spain] (Vall d’Hebron Hospital), Universitat Autònoma de Barcelona (UAB)-Vall d'Hebron University Hospital [Barcelona], Department of Nephrology [Izmir, Turkey], Tepecik Training and Research Hospital [Izmir, Turkey], Regional Nephrology Unit [Belfast, UK], Belfast City Hospital [Belfast, UK], Nefrologia, Dialisi e Trapianto di rene [Ancona, Italy], AO Torrette Umberto I [Ancona, Italy], Nephrology/Transplantation [Liverpool, UK], Royal Liverpool University Hospital [Liverpool, UK], Department of Nephrology and Renal Transplantation [Leuven, Belgium], University Hospitals Leuven [Leuven]-Catholic University Leuven, Nephrology Ward [Pilsen, Czech Republic] (Department of Internal Medicine), University Hospital Pilsen [Pilsen, Czech Republic], Istanbul University, Servicio de Nefrología, Hospital Universitario, A Coruña, Transplant Centre, University Hospital Louis Pasteur Kosice, University of Turin, St. Orsola University Hospital, University of Bologna, Hospital Universitario Central de Asturias (HUCA), Service Néphrologie [Roubaix], Hôpital Victor Provo, Leids Universitair Medisch Centrum [Leiden, The Netherlands], Néphrologie - Médecine Interne - Hypertension Pédiatrique, Hôpital des Enfants, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Service Néphrologie - Immunoclinique [CHRU Tours], Hôpital Bretonneau, Hospital Universitario Virgen del Rocío [Sevilla], Service de Néphrologie et Transplantation rénale [CHRU-lille], University Medicine Göttingen, Service de Néphrologie-Dialyse-Transplantation rénale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), University of Bern [Bern, Switzerland] (University Hospital Bern ), Transplantation rénale [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Hospital General Universitario de Alicante, Universitätsklinikum Ulm - University Hospital of Ulm, Hospital Universitario Germans Trias I Pujol, University Hospital Hamburg-Eppendorf, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'hémodialyse et de Néphrologie [Libourne], Hôpital Robert Boulin, CHRU - Service de néphrologie, dialyse et transplantation rénale, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Département de Néphrologie et transplantation [Hôpital Saint Louis - APHP], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Kidney Transplant Az. Osp. G. Brotzu, Hospital Universitario Insular de Gran Canaria, University Hospital in Krakow, Marmara School of Medicine Hastanesi, Institute of Transplantation Urology and Nephrology [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Research Center of Epidemiology, Biostatistics and Clinical Research, Nephrology-Renal Transplantation Department, Université libre de Bruxelles (ULB)-Universitair Ziekenhuis Antwerp, ERA-EDTA-DESCARTES working group, the Fonds Erasme (research grant), the Fonds Carine Vyghen, the Fonds Horlait-Dapsens, the RTRS Fondation de Coopération Scientiﬁque CENTAURE and the IHUCesti project., ANR-10-IBHU-0005,CESTI (TSI-IHU),Centre Européen des Sciences de la Transplantation et de l'Immunothérapie (TSI-IHU)(2010), Le Bihan, Sylvie, Instituts Hospitalo-Universitaires B - Centre Européen des Sciences de la Transplantation et de l'Immunothérapie (TSI-IHU) - - CESTI (TSI-IHU)2010 - ANR-10-IBHU-0005 - IBHU - VALID, Ss. Cyril and Methodius University in Skopje (UKIM), Tel Aviv University (TAU)-Rabin Medical Center [Tel Aviv, Israël], Università degli studi di Torino = University of Turin (UNITO), University of Bologna/Università di Bologna, Service Néphrologie, médecine interne et hypertension pédiatrique [CHU Toulouse], Pôle Enfants [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CUB Hôpital Erasme [Bruxelles, Belgium]-Université libre de Bruxelles (ULB), and Hadaya, Karine
Subjects: 0301 basic medicine, Nephrology, Graft Rejection, Male, medicine.medical_treatment, 030230 surgery, Kidney transplant, 0302 clinical medicine, Surveys and Questionnaires, Allograft survival, Kidney transplantation, ddc:616, Graft Survival/immunology, Survival Rate/trends, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Incidence, Graft Survival, Immunosuppression, operational tolerance, Transplantation, 3. Good health, Europe, Survival Rate, frequency, minimally immunosuppressed patients, Female, Hemodialysis, Graft Rejection/epidemiology/immunology/prevention & control, Homologous, Adult, medicine.medical_specialty, Ronyons -- Trasplantació -- Aspectes immunològics, Immunosuppression/methods, kidney transplantation, Europe/epidemiology, 03 medical and health sciences, Immune Tolerance/immunology, Internal medicine, medicine, Immune Tolerance, Humans, Transplantation, Homologous, Survival rate, Immunosuppression Therapy, graft survival, business.industry, medicine.disease, Kidney Transplantation, Transplant Recipients, Surgery, 030104 developmental biology, Operational tolerance, Human medicine, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Background Kidney recipients maintaining a prolonged allograft survival in the absence of immunosuppressive drugs and without evidence of rejection are supposed to be exceptional. The ERA-EDTA-DESCARTES working group together with Nantes University launched a European-wide survey to identify new patients, describe them and estimate their frequency for the first time. Methods Seventeen coordinators distributed a questionnaire in 256 transplant centres and 28 countries in order to report as many operationally tolerant patients (TOL; defined as having a serum creatinine
Published: 2015
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19. Using online presence data for recommending human resources in the OP4L project

Author: Grandbastien, Monique, Loskovska, Suzana, Nowakowski, Samuel, Jovanovic, Jelena, Nowakowski, Samuel, Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria), Faculty of Computer Science and Engineering, Ss. Cyril and Methodius University in Skopje, Knowledge Information and Web Intelligence (KIWI), Department of Complex Systems, Artificial Intelligence & Robotics (LORIA - AIS), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria), Maison des Sciences de l'Homme Lorraine (MSH Lorraine), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Faculty of Organizational Sciences (FOS), University of Belgrade [Belgrade], Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Ss. Cyril and Methodius University in Skopje (UKIM), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), and Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: social semantic web, [INFO.EIAH] Computer Science [cs]/Technology for Human Learning, [SHS.EDU]Humanities and Social Sciences/Education, [SHS.EDU] Humanities and Social Sciences/Education, ACM: K.: Computing Milieux/K.3: COMPUTERS AND EDUCATION, online presence, [INFO.EIAH]Computer Science [cs]/Technology for Human Learning, social presence, ontology based resource recommendation, Web-based learning
Abstract: International audience; In order to help and support learning practices, the development of web-based Personal Learning Environments (PLE) is widely adopted. A PLE is a set of services customized by the student. Among these services, resource (either digital or human) recommendation is a crucial one. The paper briefly reviews existing approaches for recommending resources in PLE. Then it describes a novel approach implemented in the OP4L prototype. OP4L is combining Social Web presence data and semantic web technologies, based on an intensive use of ontological models to represent the learning context. Then the paper reports about qualitative studies that were conducted with students on the currently available version of the OP4L prototype. The aim of the study was to get students' feedbacks about new online presence services offered in a LMS.
Published: 2012

20. Risks, benefits, and knowledge gaps of non-native tree species in Europe

Author: Anastazija Dimitrova, Katalin Csilléry, Marcin Klisz, Mathieu Lévesque, Steffi Heinrichs, Maxime Cailleret, Enrique Andivia, Palle Madsen, Henrik Böhenius, Branislav Cvjetkovic, Bart De Cuyper, Giovanbattista de Dato, Peter Ferus, Berthold Heinze, Vladan Ivetić, Zoltan Köbölkuti, Jelena Lazarević, Dagnija Lazdina, Tiit Maaten, Kristaps Makovskis, Jelena Milovanović, Antonio T. Monteiro, Marina Nonić, Simon Place, Radoslaw Puchalka, Antonio Montagnoli, Ss. Cyril and Methodius University in Skopje (UKIM), Swiss Federal Institute for Forest, Snow and Landscape Research WSL, FOREST RESEARCH INSTITUTE RASZYN POL, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Department of Environmental Systems Science [ETH Zürich] (D-USYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Georg-August-University = Georg-August-Universität Göttingen, Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), InNovaSilva ApS, Swedish University of Agricultural Sciences (SLU), University of Banja Luka, Research Institute for Nature and Forest (INBO), CREA – Research Centre for Forestry and Wood, Arezzo, Italy, Slovak Academy of Sciences (SAS), Austrian Research Centre for Forests (BFW), University of Belgrade [Belgrade], University of West Hungary [Sopron], University of Montenegro (UCG), Latvian State Forest Research Institute 'Silava', ESTONIAN UNIVERSITY OF LIFE SCIENCES TARTU EST, Singidunum University, University Institute of Lisbon (ISCTE), Chartered Forester UK, Nicolaus Copernicus University [Toruń], Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), European Cooperation in Science and Technology (COST)CA19128, Appeared in source as:COST (European Cooperation in Science and Technology), and Repositório da Universidade de Lisboa
Subjects: Invasive species, Ecology, Grey literature, Forestry, Distribution, Non-native tree species, assisted migration, climate change, database, distribution, forestry, grey literature, hybridization, invasive species, Climate change, Hybridization, Database, Assisted migration, Europe, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Ecology, Evolution, Behavior and Systematics
Abstract: Changing ecosystem conditions and diverse socio-economical events have contributed to an ingrained presence of non-native tree species (NNTs) in the natural and cultural European landscapes. Recent research endeavors have focused on different aspects of NNTs such as legislation, benefits, and risks for forestry, emphasizing that large knowledge gaps remain. As an attempt to fulfill part of these gaps, within the PEN-CAFoRR COST Action (CA19128) network, we established an open-access questionnaire that allows both academic experts and practitioners to provide information regarding NNTs from 20 European countries. Then, we integrated the data originating from the questionnaire, related to the country-based assessment of both peer-reviewed and grey literature, with information from available datasets (EUFORGEN and EU-Forest), which gave the main structure to the study and led to a mixed approach review. Finally, our study provided important insights into the current state of knowledge regarding NNTs. In particular, we highlighted NNTs that have shown to be less commonly addressed in research, raising caution about those characterized by an invasive behavior and used for specific purposes (e.g., wood production, soil recultivation, afforestation, and reforestation). NNTs were especially explored in the context of resilient and adaptive forest management. Moreover, we emphasized the assisted and natural northward migration of NNTs as another underscored pressing issue, which needs to be addressed by joint efforts, especially in the context of the hybridization potential. This study represents an additional effort toward the knowledge enhancement of the NNTs situation in Europe, aiming for a continuously active common source deriving from interprofessional collaboration., Frontiers in Ecology and Evolution, 10, ISSN:2296-701X
Published: 2022
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21. Characterization of coal from the Mariovo basin, Macedonia – Insights from organic geochemical and sulphur isotopic data

Author: Lerouge, Catherine, Gouin, Jérôme, Deschamps, Yves, Laggoun-Défarge, Fatima, Tasev, G., Serafimovski, T., Yossifova, M.G., Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Institut des Sciences de la Terre d'Orléans (ISTO), Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), St. Cyril and St. Methodius University in Skopje, Geological Institute of BAS, Bulgarian Academy of Sciences (BAS), and This work was financially supported by the ECO-NET program (10161XM) between the BRGM (France), the Geological Institute of Sofia, Bulgarian Academy of Sciences (Bul-garia) and the University of Skopje (Mace-donia).
Subjects: 91.67.Ty, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, fungi, electron microprobe, organic sulphur, metals, Mariovo basin, vitrinite reflectance, Macedonia, Coal chemistry
Abstract: International audience; data detailed petrographic study of coal from the Mariovo basin in Macedonia suggests circulation of fluids mobilizing metals from different origins (basement, volcanism ?) during burial. Sulphur isotopic data on organic matter and pyrite indicate dominantly marine-derive fluids and processus of bacterial reduction of sulphates
Published: 2007

22. Bringing the margin to the focus:10 challenges for riparian vegetation science and management

Author: Patricia M. Rodríguez‐González, Eleni Abraham, Francisca Aguiar, Andrea Andreoli, Ligita Baležentienė, Naim Berisha, Ivan Bernez, Michael Bruen, Daniel Bruno, Carlo Camporeale, Andraž Čarni, Mila Chilikova‐Lubomirova, Dov Corenblit, Renata Ćušterevska, Tanya Doody, Judy England, André Evette, Robert Francis, Virginia Garófano‐Gómez, Marta González del Tánago, Yasar Selman Gultekin, Florian Guyard, Seppo Hellsten, Georgi Hinkov, Jiří Jakubínský, Philippe Janssen, Roland Jansson, Jochem Kail, Emine Keles, Mary Kelly‐Quinn, Anna Kidová, Tímea Kiss, Mart Kulvik, Nicola La Porta, Marianne Laslier, Melissa Latella, Stefan Lorenz, Dejan Mandžukovski, Paraskevi Manolaki, Vanesa Martinez‐Fernández, David Merritt, Adrien Michez, Jelena Milovanović, Tomasz Okruszko, Eva Papastergiadou, Ellis Penning, Remigiusz Pielech, Emilio Politti, Ana Portela, Tenna Riis, Željko Škvorc, Michal Slezák, Barbara Stammel, John Stella, Danijela Stesevic, Vladimir Stupar, Olga Tammeorg, Priit Tammeorg, Therese Moe Fosholt, Gorazd Urbanič, Marc Villar, Ioannis Vogiatzakis, Paul Vrchovsky, Rasoul Yousefpour, Peggy Zinke, Tzvetan Zlatanov, Simon Dufour, Ecosystems and Environment Research Programme, Department of Agricultural Sciences, Viikki Plant Science Centre (ViPS), Crop Science Research Group, Helsinki Institute of Sustainability Science (HELSUS), AgriChar research group, Plant Production Sciences, University of Helsinki, Centro de Estudos Florestais, Instituto Superior de Agronomia [Lisboa] (ISA), Universidade de Lisboa = University of Lisbon (ULISBOA)-Universidade de Lisboa = University of Lisbon (ULISBOA), Laboratório Associado Terra, School of Agriculture, Forestry and Natural Environment, Aristotle University of Thessaloniki, Faculty of Science and Technology, Free University of Bozen-Bolzano, Institute of Environment and Ecology, Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Department of Biology, Faculty of Mathematics and Natural Sciences, University of Prishtina, Dynamique et durabilité des écosystèmes : de la source à l’océan (DECOD), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UCD Earth Institute & UCD Dooge Centre for Water Resources Research, University College Dublin [Dublin] (UCD), Laboratoire des EcoSystèmes et des Sociétés en Montagne (UR LESSEM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Instituto Pirenaico de Ecologìa = Pyrenean Institute of Ecology [Zaragoza] (IPE - CSIC), Department of environmental, land and infrastructure engineering, Politecnico di Torino = Polytechnic of Turin (Polito), Scientific Research Centre of the Slovenian Academy of Sciences and Arts, Bulgarian Academy of Sciences (BAS), Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Faculty of Natural Sciences and Mathematics, Institute of Biology, Ss Cyril and Methodius University in Skopje, CSIRO Land and Water, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Environment Agency, King‘s College London, Instituto de Investigación para la Gestión Integrada de Zonas Costeras [Universitat Politècnica de València] (IGIC), Universitat Politècnica de València (UPV), Laboratorio de Hidrobiología, Universidad Politécnica de Madrid (UPM), Forest Economics Department, Düzce University, Geography and Spatial Planning, Université de Rennes 2 (UR2), Finnish Environment Institute (SYKE), Forest Research Institute - Department of Forest Entomology - Bulgarian Academy of Sciences (BAS), Global Change Research, Institute CAS, Department of Ecology and Environmental Science [Umeå], Umeå University, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Faculty of Architecture, Department of Landscape Architecture, Trakya University, School of Biology & Environmental Science and UCD Earth Institute, Geophysical Institute of the Slovak Academy of Sciences, Department of Geoinformatics, Physical and Environmental Geography, University of Szeged [Szeged], Estonian University of Life Sciences (EMU), Centro Ricerca e Innovazione, Fondazione Edmund Mach, Instituto Agrario S. Michele all' Adige, Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN), Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Institute for Ecological Chemistry, Plant Analysis and Stored Product Protection, Julius Kuehn-Institut, Federal Research Centre for Cultivated Plants, Institute for Plant Protection in Field Crops and Grassland, Braunschweig, Germany, Department for Forest Management Planning, PE Nacionalni sumi, Faculty of Pure and Applied Sciences, Open University of Cyprus, Museo Nacional de Ciencias Naturales [Madrid] (MNCN), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), National Stream and Aquatic Ecology Center, Biological and Physical Resources Staff, USDA, TERRA Teaching and Research Centre, Gembloux Agro-Bio Tech, Université de Liège - Gembloux-Université de Liège - Gembloux, Environment and Sustainable Development, Singidunum University, Institute of Environmental Engineering, Warsaw University of Life Sciences (SGGW), University of Patras, Department of Inland Water Systems, Deltares [The Netherlands], University of Agriculture in Krakow, Department of civil, environmental and mechanical engineering [Trento], University of Trento [Trento], Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Universidade do Porto = University of Porto, CIBIO-InBIO - Universidade do Porto, Program in Genomics, Biodiversity and Land Planning (BIOPOLIS), Department of Biology, Aarhus Universitet, Faculty of Forestry and Wood Technology [Zagreb], University of Zagreb, Institute of Forest Ecology, Slovak Academy of Sciences (SAS), Floodplain Institute, Catholic University of Eichstätt-Ingolstadt, Department of Sustainable Resources Management, SUNY College of Environmental Science and Forestry (SUNY-ESF), State University of New York (SUNY)-State University of New York (SUNY), University of Montenegro (UCG), Department of Forest Ecology, University of Banja Luka, Department of Agricultural Science, Norwegian Institute for Water Research (NIVA), Institute for Holistic Environmental Management, Ltd. (URBANZERO), Biologie intégrée pour la valorisation de la diversité des Arbres et de la Forêt (BioForA), Office national des forêts (ONF)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute of Forestry and Conservation, John H. Daniels Faculty of Architecture, Landscape, and Design, University of Toronto, Chair of Forestry Economics and Forest Planning, University of Freiburg, Sciencemonastery AS, Institute of Biodiversity and Ecosystem Research, Littoral, Environnement, Télédétection, Géomatique (LETG - Rennes ), Université de Brest (UBO)-Université de Rennes 2 (UR2)-Nantes Université (Nantes Univ)-Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (Nantes Univ - IGARUN), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (Nantes Univ - IGARUN), Nantes Université (Nantes Univ), Suomen ympäristökeskus, and The Finnish Environment Institute
Subjects: rantakasvillisuus, luonnonhoito, Settore AGR/05 - ASSESTAMENTO FORESTALE E SELVICOLTURA, riparian zone, river management, socioecosystem, nature management, water, vesi, nature conservation, Ocean Engineering, Oceanografi, hydrologi och vattenresurser, Management, Monitoring, Policy and Law, Aquatic Science, SALICACEAE, Oceanography, riparian zone, Oceanography, Hydrology and Water Resources, vegetation, RIVER, river management, socioecosystem, PLANTS, 1172 Environmental sciences, aquatic ecosystems, Water Science and Technology, Ekologi, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, Ecology, vesiekosysteemit, kasvillisuus, Miljövetenskap, ecosystems (ecology), FRAMEWORK, waterside vegetation, [SDE.ES]Environmental Sciences/Environmental and Society, ekologia, ekosysteemit (ekologia), ekosysteemipalvelut, [SDE]Environmental Sciences, FEEDBACKS, luonnonsuojelu, ecosystem services, Biologie, Environmental Sciences
Abstract: Riparian zones are the paragon of transitional ecosystems, providing critical habitat and ecosystem services that are especially threatened by global change. Following consultation with experts, 10 key challenges were identified to be addressed for riparian vegetation science and management improvement: (1) Create a distinct scientific community by establishing stronger bridges between disciplines; (2) Make riparian vegetation more visible and appreciated in society and policies; (3) Improve knowledge regarding biodiversity—ecosystem functioning links; (4) Manage spatial scale and context-based issues; (5) Improve knowledge on social dimensions of riparian vegetation; (6) Anticipate responses to emergent issues and future trajectories; (7) Enhance tools to quantify and prioritize ecosystem services; (8) Improve numerical modeling and simulation tools; (9) Calibrate methods and increase data availability for better indicators and monitoring practices and transferability; and (10) Undertake scientific validation of best management practices. These challenges are discussed and critiqued here, to guide future research into riparian vegetation. This article is categorized under: Water and Life > Nature of Freshwater Ecosystems Water and Life > Stresses and Pressures on Ecosystems Water and Life > Conservation, Management, and Awareness
Published: 2022
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23. Genomic diversity and population structure of the indigenous Greek and Cypriot cattle populations

Author: Dimitris, Papachristou, Panagiota, Koutsouli, George P, Laliotis, Elisabeth, Kunz, Maulik, Upadhyay, Doris, Seichter, Ingolf, Russ, Bunevski, Gjoko, Nikolaos, Kostaras, Iosif, Bizelis, Ivica, Medugorac, Agricultural University of Athens, Ludwig-Maximilians-Universität München (LMU), and Ss. Cyril and Methodius University in Skopje
Subjects: Reproductive Isolation, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Greece, lcsh:QH426-470, Genetic Introgression, Polymorphism, Single Nucleotide, humanities, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, lcsh:Genetics, Gene Frequency, Cyprus, Animals, Cattle, lcsh:Animal culture, geographic locations, Research Article, lcsh:SF1-1100
Abstract: International audience; Background: The indigenous cattle populations from Greece and Cyprus have decreased to small numbers and are currently at risk of extinction due to socio-economic reasons, geographic isolation and crossbreeding with commercial breeds. This study represents the first comprehensive genome-wide analysis of 10 indigenous cattle populations from continental Greece and the Greek islands, and one from Cyprus, and compares them with 104 international breeds using more than 46,000 single nucleotide polymorphisms (SNPs).Results: We estimated several parameters of genetic diversity (e.g. heterozygosity and allelic diversity) that indicated a severe loss of genetic diversity for the island populations compared to the mainland populations, which is mainly due to the declining size of their population in recent years and subsequent inbreeding. This high inbreeding status also resulted in higher genetic differentiation within the Greek and Cyprus cattle group compared to the remaining geographical breed groups. Supervised and unsupervised cluster analyses revealed that the phylogenetic patterns in the indigenous Greek breeds were consistent with their geographical origin and historical information regarding crosses with breeds of Anatolian or Balkan origin. Cyprus cattle showed a relatively high indicine ancestry. Greek island populations are placed close to the root of the tree as defined by Gir and the outgroup Yak, whereas the mainland breeds share a common historical origin with Buša. Unsupervised clustering and D-statistics analyses provided strong support for Bos indicus introgression in almost all the investigated local cattle breeds along the route from Anatolia up to the southern foothills of the Alps, as well as in most cattle breeds along the Apennine peninsula to the southern foothills of the Alps.Conclusions: All investigated Cyprus and Greek breeds present complex mosaic genomes as a result of historical and recent admixture events between neighbor and well-separated breeds. While the contribution of some mainland breeds to the genetic diversity pool seems important, some island and fragmented mainland breeds suffer from a severe decline of population size and loss of alleles due to genetic drift. Conservation programs that are a compromise between what is feasible and what is desirable should focus not only on the still highly diverse mainland breeds but also promote and explore the conservation possibilities for island breeds.
Published: 2020
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24. Overview of Cattle Diseases Listed Under Category C, D or E in the Animal Health Law for Which Control Programmes Are in Place Within Europe

Author: Hodnik, Jaka Jakob, Acinger-Rogi��, ��aklin, Alishani, Mentor, Autio, Tiina, Balseiro, Ana, Berezowski, John, Carmo, Luis Pedro, Chaligiannis, Ilias, Conrady, Beate, Costa, Lina, Cvetkovikj, Iskra, Davidov, Ivana, Dispas, Marc, Djadjovski, Igor, Duarte, Elsa Leclerc, Faverjon, C��line, Fourichon, Christine, Fr��ssling, Jenny, Gerilovych, Anton, Gethmann, J��rn, Gomes, Jacinto, Graham, David, Guelbenzu, Maria, Gunn, George J, Henry, Madeleine K, Hopp, Petter, Houe, Hans, Irimia, Elena, Je��ek, Jo��ica, Juste, Ramon A, Kalaitzakis, Emmanouil, Kaler, Jasmeet, Kaplan, Selcuk, Kostoulas, Polychronis, Kovalenko, Kaspars, Kne��evi��, Nada, Knific, Tanja, Koleci, Xhelil, Madouasse, Aur��lien, Malakauskas, Alvydas, Mandelik, Rene, Meletis, Eleftherios, Mincu, Madalina, M��tus, Kerli, Mu��oz-G��mez, Violeta, Niculae, Mihaela, Nikitovi��, Jelena, Ocepek, Matja��, Tangen-Opsal, Marie, ��zsv��ri, L��szl��, Papadopoulos, Dimitrios, Papadopoulos, Theofilos, Pelkonen, Sinikka, Polak, Miroslaw Pawel, Pozzato, Nicola, Rapaliut��, Egl��, Ribbens, Stefaan, Niza-Ribeiro, Jo��o, Roch, Franz-Ferdinand, Rosenbaum Nielsen, Liza, Saez, Jose Luis, Nielsen, S��ren Saxmose, van Schaik, Gerdien, Schwan, Ebba, Sekovska, Blagica, Stari��, Jo��e, Strain, Sam, ��atran, Petr, ��eri��-Hara��i��, Sabina, Tamminen, Lena-Mari, Thulke, Hans-Hermann, Toplak, Ivan, Tuunainen, Erja, Verner, Sharon, Vil��ek, ��tefan, Yildiz, Ramazan, Santman-Berends, Inge M G A, University of Ljubljana, Ministry of Agriculture [Zagreb, Croatia], University of Prishtina, Finnish Food Authority, Partenaires INRAE, Universidad de León [León], University of Bern, Aristotle University of Thessaloniki, Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU), Complexity Science Hub Vienna (CSHV), Politécnico de Portalegre = Polytechnic Institute of Portalegre, Ss. Cyril and Methodius University in Skopje, University of Novi Sad, Sciensano [Bruxelles], Réseau International des Instituts Pasteur (RIIP), Universidade de Évora, Ausvet Europe, Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), National Veterinary Institute [Uppsala] (SVA), V.N. Karazin Kharkiv National University (KhNU), National Scientific Centre - Institute for Experimental and Clinical Veterinary Medicine [Kharkiv, Ukraine] (NSC - IECVM), Friedrich-Loeffler-Institut (FLI), Instituto Nacional de Investigação Agrária e Veterinária = National Institute for Agrarian and Veterinary Research [Oeiras, Portugal] (INIAV), Animal Health Ireland (AHI), Scotland's Rural College (SRUC), Norwegian Veterinary Institute [Oslo], Research and Development Institute for Bovine Balotesti (RDIB), Instituto Vasco de Investigación y Desarrollo Agrario [Derio] (NEIKER), University of Nottingham, UK (UON), Tekirdag Namik Kemal University (NKÜ), University of Thessaly [Volos] (UTH), University of Latvia (LU), Podravka d.d, Agricultural University of Tirana, Lithuanian University of Health Sciences [Kaunas, Lithuania], University of Veterinary Medicine and Pharmacy [Košice, Slovakia], Estonian University of Life Sciences (EMU), University of Zurich, Vetsuisse-Faculty, University of Agricultural Sciences and Veterinary Medicine Cluj Napoca, University of Banja Luka, Norwegian Food Safety Authority, University of Veterinary Medicine [Budapest, Hungary], National Veterinary Research Institute [Pulawy, Pologne] (NVRI), Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Animal Health Care Flanders, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, University of Veterinary Medicine [Vienna] (Vetmeduni), Ministry of Agriculture, Fisheries and Food, Utrecht University [Utrecht], Royal GD [Deventer], Farm and Animal Health, Animal Health and Welfare Northern Ireland, State Veterinary Institute Prague, University of Sarajevo, UNIVERZITET U SARAJEVU, Swedish University of Agricultural Sciences (SLU), Department of Ecological Modelling [UFZ Leipzig], Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Animal Health ETT, Burdur Mehmet Akif Ersoy University, This article is based upon work fromCOST Action Standardising output-based surveillance to control non-regulated diseases of cattle in the European Union (SOUND control) CA17110 supported by COST (European Cooperation in Science and Technology)3. COST is a funding agency for research and innovation networks. Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation., Balseiro Morales, Ana María [0000-0002-5121-7264], FAH Evidence based Veterinary Medicine, FAH veterinaire epidemiologie, dFAH AVR, Dep Gezondheidszorg Landbouwhuisdieren, and Balseiro Morales, Ana María
Subjects: Europe, 630 Agriculture, General Veterinary, Control programmes, Disease control, [SDV]Life Sciences [q-bio], Output-based standards, SOUND control, Veterinary Science, Cattle, veterinary(all), Original Research
Abstract: 13 páginas, 5 figuras, 3 tablas., The COST action “Standardising output-based surveillance to control non-regulated diseases of cattle in the European Union (SOUND control),” aims to harmonise the results of surveillance and control programmes (CPs) for non-EU regulated cattle diseases to facilitate safe trade and improve overall control of cattle infectious diseases. In this paper we aimed to provide an overview on the diversity of control for these diseases in Europe. A non-EU regulated cattle disease was defined as an infectious disease of cattle with no or limited control at EU level, which is not included in the European Union Animal health law Categories A or B under Commission Implementing Regulation (EU) 2020/2002. A CP was defined as surveillance and/or intervention strategies designed to lower the incidence, prevalence, mortality or prove freedom from a specific disease in a region or country. Passive surveillance, and active surveillance of breeding bulls under Council Directive 88/407/EEC were not considered as CPs. A questionnaire was designed to obtain country-specific information about CPs for each disease. Animal health experts from 33 European countries completed the questionnaire. Overall, there are 23 diseases for which a CP exists in one or more of the countries studied. The diseases for which CPs exist in the highest number of countries are enzootic bovine leukosis, bluetongue, infectious bovine rhinotracheitis, bovine viral diarrhoea and anthrax (CPs reported by between 16 and 31 countries). Every participating country has on average, 6 CPs (min–max: 1–13) in place. Most programmes are implemented at a national level (86%) and are applied to both dairy and non-dairy cattle (75%). Approximately one-third of the CPs are voluntary, and the funding structure is divided between government and private resources. Countries that have eradicated diseases like enzootic bovine leukosis, bluetongue, infectious bovine rhinotracheitis and bovine viral diarrhoea have implemented CPs for other diseases to further improve the health status of cattle in their country. The control of non-EU regulated cattle diseases is very heterogenous in Europe. Therefore, the standardising of the outputs of these programmes to enable comparison represents a challenge.
Published: 2021
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25. Correlation functions for the fractional generalized Langevin equation in the presence of internal and external noise

Author: Tomovski, Živorad [Faculty of Natural Sciences and Mathematics, Institute of Mathematics, Saints Cyril and Methodius University, 1000 Skopje (Macedonia, The Former Yugoslav Republic of)]
Published: 2014
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26. Root traits explain plant species distributions along climatic gradients yet challenge the nature of ecological trade-offs

Author: Oscar J. Valverde-Barrantes, Jasper van Ruijven, M. Luke McCormack, Ülo Niinemets, Hendrik Poorter, Renata Ćušterevska, Jonathan Lenoir, Ina C. Meier, Marco Schmidt, Fons van der Plas, Peter B. Reich, Grégoire T. Freschet, Francesco Maria Sabatini, Joana Bergmann, Thomas W. Kuyper, Jens Kattge, Catherine Roumet, Marina Semchenko, Josep Peñuelas, Isabelle Aubin, Gregory Richard Guerin, Wim A. Ozinga, Chaeho Byun, Helge Bruelheide, Franziska Schrodt, Olivia R. Burge, Christopher J. Sweeney, Nathaly R. Guerrero-Ramírez, Daniel C. Laughlin, Larry M. York, Colleen M. Iversen, Robert B. Jackson, Estelle Forey, Eduardo Velázquez, Liesje Mommer, Jürgen Dengler, Tatiana Lysenko, Bruno Hérault, Dirk Nikolaus Karger, Patrick Meir, Alexandra Weigelt, Station d'écologie théorique et expérimentale (SETE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Département écologie et biodiversité des milieux forestiers, prairiaux et aquatiques (ECODIV), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), German Research Foundation, Biological and Environmental Research (US), University of Göttingen, Laughlin, Daniel C., Mommer, Liesje, Sabatini, Francesco Maria, Bruelheide, Helge, Kuyper, Thom W., McCormack, M. Luke, Bergmann, Joana, Freschet, Grégoire T., Guerrero-Ramírez, Nathaly R., Iversen, Colleen M., Kattge, Jens, Meier, Ina C., Poorter, Hendrik, Roumet, Catherine, Semchenko, Marina, Valverde-Barrantes, Oscar J., van der Plas, Fons, van Ruijven, Jasper, York, Larry M., Aubin, Isabelle, Burge, Olivia R., Byun, Chaeho, Ćušterevska, Renata, Dengler, Jürgen, Forey, Estelle, Guerin, Greg R., Hérault, Bruno, Jackson, Robert B., Karger, Dirk Nikolaus, Lenoir, Jonathan, Lysenko, Tatiana, Meir, Patrick, Niinemets, Ülo, Ozinga, Wim A., Peñuelas, Josep, Reich, Peter B., Schmidt, Marco, Schrodt, Franziska, Weigelt, Alexandra, University of Wyoming (UW), Wageningen University and Research [Wageningen] (WUR), German Centre for Integrative Biodiversity Research (iDiv), Martin-Luther-University Halle-Wittenberg, The Morton Arboretum, Leibniz-Zentrum für Agrarlandschaftsforschung = Leibniz Centre for Agricultural Landscape Research (ZALF), Station d'Ecologie Théorique et Expérimentale (SETE), Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Agrobiosciences, Interactions et Biodiversité (FR AIB), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Georg-August-University = Georg-August-Universität Göttingen, Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, Max Planck Institute for Biogeochemistry (MPI-BGC), Max-Planck-Gesellschaft, Universität Hamburg (UHH), IBG-2, Institute for Bio and Geosciences, Macquarie University, Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), University of Manchester [Manchester], University of Tartu, Florida International University [Miami] (FIU), Leipzig University, Noble Research Institute, Great Lakes Forestry Centre, Sault Sainte Marie, Ontario, Manaaki Whenua – Landcare Research [Lincoln], Andong National University, Ss. Cyril and Methodius University in Skopje (UKIM), Zürich University of Applied Sciences (ZHAW), University of Bayreuth, University of Adelaide, University of Queensland [Brisbane], Forêts et Sociétés (UPR Forêts et Sociétés), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Institut National Polytechnique Félix Houphouët Boigny de Yamoussoukro (INP-HB), Stanford University, Stanford Woods Institute for the Environment, Institut Fédéral de Recherches sur la Forêt, la Neige et le Paysage (WSL), Institut Fédéral de Recherches [Suisse], Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 (EDYSAN), Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Russian Academy of Sciences [Moscow] (RAS), Australian National University (ANU), University of Edinburgh, Estonian University of Life Sciences (EMU), CREAF - Centre for Ecological Research and Applied Forestries, University of Minnesota System, Western Sydney University, Senckenberg Biodiversity and Climate Research Centre (SBiK-F), Goethe-Universität Frankfurt am Main-Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, Leibniz Association-Leibniz Association, University of Nottingham, UK (UON), Universidad de Valladolid [Valladolid] (UVa), Laughlin D.C., Mommer L., Sabatini F.M., Bruelheide H., Kuyper T.W., McCormack M.L., Bergmann J., Freschet G.T., Guerrero-Ramirez N.R., Iversen C.M., Kattge J., Meier I.C., Poorter H., Roumet C., Semchenko M., Sweeney C.J., Valverde-Barrantes O.J., van der Plas F., van Ruijven J., York L.M., Aubin I., Burge O.R., Byun C., Custerevska R., Dengler J., Forey E., Guerin G.R., Herault B., Jackson R.B., Karger D.N., Lenoir J., Lysenko T., Meir P., Niinemets U., Ozinga W.A., Penuelas J., Reich P.B., Schmidt M., Schrodt F., Velazquez E., and Weigelt A.
Subjects: 0106 biological sciences, Environmental change, Range (biology), Climate, Ecophysiology, Bos- en Landschapsecologie, Forests, 01 natural sciences, Système racinaire, Forest and Landscape Ecology, ComputingMilieux_MISCELLANEOUS, Ecology, Facteur du milieu, Soil Biology, PE&RC, Physiologie végétale, Phenotype, 580: Pflanzen (Botanik), Biogeography, [SDE]Environmental Sciences, Trait, Plantenecologie en Natuurbeheer, Vegetatie, Bos- en Landschapsecologie, Écologie, F40 - Écologie végétale, Facteur écologique, F60 - Physiologie et biochimie végétale, Biogéographie, Plant Ecology and Nature Conservation, Biology, 010603 evolutionary biology, ddc:570, Life Science, Forest, Community ecology, 577: Ökologie, Plant Dispersal, Vegetatie, Ecology, Evolution, Behavior and Systematics, Bodembiologie, Environmental gradient, Vegetation, Community, Directional selection, Water, 15. Life on land, Natural variation in plants, Vegetation, Forest and Landscape Ecology, 010606 plant biology & botany
Abstract: 21 Pág. Instituto de Ciencias Forestales (ICIFOR), Ecological theory is built on trade-offs, where trait differences among species evolved as adaptations to different environments. Trade-offs are often assumed to be bidirectional, where opposite ends of a gradient in trait values confer advantages in different environments. However, unidirectional benefits could be widespread if extreme trait values confer advantages at one end of an environmental gradient, whereas a wide range of trait values are equally beneficial at the other end. Here, we show that root traits explain species occurrences along broad gradients of temperature and water availability, but model predictions only resembled trade-offs in two out of 24 models. Forest species with low specific root length and high root tissue density (RTD) were more likely to occur in warm climates but species with high specific root length and low RTD were more likely to occur in cold climates. Unidirectional benefits were more prevalent than trade-offs: for example, species with large-diameter roots and high RTD were more commonly associated with dry climates, but species with the opposite trait values were not associated with wet climates. Directional selection for traits consistently occurred in cold or dry climates, whereas a diversity of root trait values were equally viable in warm or wet climates. Explicit integration of unidirectional benefits into ecological theory is needed to advance our understanding of the consequences of trait variation on species responses to environmental change., sPlot was initiated by sDiv and funded by the German Research Foundation (FZT 118) and is now a platform of iDiv. The sRoot workshops and L.M. were also supported by NWO-Vidi grant 864.14.006. C.M.I. and the Fine-Root Ecology Database were supported by the Biological and Environmental Research program in the US Department of Energy’s Office of Science. J.B. was supported by Deutsche Forschungsgemeinschaft (DFG) project 432975993. N.R.G.-R. thanks the Dorothea Schlözer Postdoctoral Programme of the Georg-August-Universität.
Published: 2021
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27. Long‐term safety and effectiveness of berotralstat for hereditary angioedema: The open‐label APeX‐S study

Author: David Hagin, Emel Aygören-Pürsün, Aarnoud Huissoon, Olivier Fain, Marcus Maurer, Sorena Kiani-Alikhan, William P. Sheridan, Urs C. Steiner, Marcin Stobiecki, Adrian Wu, Melanie Cornpropst, Bhavisha Desai, Avner Reshef, Sylvia Dobo, Celia Zubrinich, Anette Bygum, Henriette Farkas, Jonny Peter, Eniko Nagy, Heather Iocca, Jessica M. Best, Daniel Dix, Vesna Grivcheva Panovska, Tamar Kinaciyan, S. Murray, Miloš Jeseňák, Karen Lindsay, University of Zurich, Sheridan, William P, Semmelweis University [Budapest], Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University of Cape Town, University of Vienna [Vienna], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Goethe-University Frankfurt am Main, Royal Free Hospital [London, UK], The University of Hong Kong (HKU), Barzilai Medical Center, University of Southern Denmark (SDU), Service de médecine interne [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Tel Aviv University [Tel Aviv], University Hospitals Birmingham [Birmingham, Royaume-Uni], Comenius University in Bratislava, University of Auckland [Auckland], Ss. Cyril and Methodius University in Skopje, University hospital of Zurich [Zurich], Melbourne School of Health Sciences [Melbourne], Faculty of Medicine, Dentistry and Health Sciences [Melbourne], University of Melbourne-University of Melbourne, and BioCryst Pharmaceuticals
Subjects: safety, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Abdominal pain, Immunology, 610 Medicine & health, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, medicine, Immunology and Allergy, Adverse effect, long-term, 2403 Immunology, Angioedema, business.industry, Research, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, RC581-607, medicine.disease, Interim analysis, berotralstat, hereditary angioedema, 3. Good health, Diarrhea, Upper respiratory tract infection, 030228 respiratory system, 2740 Pulmonary and Respiratory Medicine, Hereditary angioedema, 10033 Clinic for Immunology, 2723 Immunology and Allergy, long‐term, prophylaxis, Immunologic diseases. Allergy, medicine.symptom, business
Abstract: Background: Berotralstat (BCX7353) is an oral, once-daily inhibitor of plasma kallikrein recently approved for prevention of angioedema attacks in adults and adolescents with hereditary angioedema (HAE). The objective of this report is to summarize results from an interim analysis of an ongoing long-term safety study of berotralstat in patients with HAE. Methods: APeX-S is an ongoing, phase 2, open-label study conducted in 22 countries (ClinicalTrials.gov, NCT03472040). Eligible patients with a clinical diagnosis of HAE due to C1 inhibitor deficiency (HAE-C1-INH) were centrally allocated to receive berotralstat 150 or 110 mg once daily. The primary objective was to determine long-term safety and the secondary objective was to evaluate effectiveness. Results: Enrolled patients (N = 227) received berotralstat 150 mg (n = 127) or 110 mg (n = 100) once daily. The median (range) duration of exposure was 342 (11–540) and 307 (14–429) days for the 150-mg and 110-mg groups, respectively. Treatment-emergent adverse events (TEAEs) occurred in 91% (n = 206) of patients. The most common TEAEs across treatment groups were upper respiratory tract infection (n = 91, 40%), abdominal pain (n = 57, 25%), headache (n = 40, 18%), and diarrhea (n = 31, 14%) and were mostly mild to moderate. Fifty percent (n = 113) of patients had at least one drug-related adverse event (AE; 150 mg, n = 57 [45%]; 110 mg, n = 56 [56%]), and discontinuations due to AEs occurred in 19 (8%) patients (150 mg, n = 13 [10%]; 110 mg, n = 6 [6%]). Three (1.3%) patients experienced a drug-related serious TEAE. Among patients who received berotralstat through 48 weeks (150 mg, n = 73; 110 mg, n = 30), median HAE attack rates were low in month 1 (150 mg, 1.0 attacks/month; 110 mg, 0.5 attacks/month) and remained low through 12 months (0 attacks/month in both dose groups). Mean HAE attack rates followed a similar trend, and no evidence for patient tolerance to berotralstat emerged. In both dose groups, angioedema quality of life scores showed clinically meaningful changes from baseline. Conclusions: In this analysis, both berotralstat doses, 150 and 110 mg once daily, were generally well tolerated. Effectiveness results support the durability and robustness of berotralstat as prophylactic therapy in patients with HAE. Trial registration: The study is registered with ClinicalTrials.gov (NCT03472040).
Published: 2021
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28. Using Expert Elicitation to Abridge the Welfare Quality® Protocol for Monitoring the Most Adverse Dairy Cattle Welfare Impairments

Author: Frank A. M. Tuyttens, Sophie de Graaf, Sine Norlander Andreasen, Alice de Boyer des Roches, Frank J. C. M. van Eerdenburg, Marie J. Haskell, Marlene K. Kirchner, Luc. Mounier, Miroslav Kjosevski, Jo Bijttebier, Ludwig Lauwers, Wim Verbeke, Bart Ampe, Research Institute for Agricultural, Fisheries and Food (ILVO), Universiteit Gent = Ghent University [Belgium] (UGENT), University of Copenhagen = Københavns Universitet (KU), Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Utrecht University [Utrecht], Scotland's Rural College (SRUC), Ss. Cyril and Methodius University in Skopje, FAH veterinaire epidemiologie, and dFAH AVR
Subjects: index, Index (economics), 040301 veterinary sciences, media_common.quotation_subject, Veterinary medicine, FARM-ANIMAL-WELFARE, integration, PARAMETERS, LAYING HENS, animal welfare, 0403 veterinary science, compensation, SYSTEMS, Animal welfare, Environmental health, FLOCKS, SF600-1100, dairy cattlei, Quality (business), PIGS, Veterinary Sciences, Dairy cattle, Original Research, media_common, 2. Zero hunger, Protocol (science), COW WELFARE, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, General Veterinary, 0402 animal and dairy science, aggregation, dairy cattle, Expert elicitation, 04 agricultural and veterinary sciences, 040201 dairy & animal science, veterinary(all), ntegration, TIME, OPINION, Categorization, welfare assessment, Veterinary Science, Business, SENSITIVITY, Welfare
Abstract: The Welfare Quality® consortium has developed and proposed standard protocols for monitoring farm animal welfare. The uptake of the dairy cattle protocol has been below expectation, however, and it has been criticized for the variable quality of the welfare measures and for a limited number of measures having a disproportionally large effect on the integrated welfare categorization. Aiming for a wide uptake by the milk industry, we revised and simplified the Welfare Quality® protocol into a user-friendly tool for cost- and time-efficient on-farm monitoring of dairy cattle welfare with a minimal number of key animal-based measures that are aggregated into a continuous (and thus discriminative) welfare index (WI). The inevitable subjective decisions were based upon expert opinion, as considerable expertise about cattle welfare issues and about the interpretation, importance, and validity of the welfare measures was deemed essential. The WI is calculated as the sum of the severity score (i.e., how severely a welfare problem affects cow welfare) multiplied with the herd prevalence for each measure. The selection of measures (lameness, leanness, mortality, hairless patches, lesions/swellings, somatic cell count) and their severity scores were based on expert surveys (14–17 trained users of the Welfare Quality® cattle protocol). The prevalence of these welfare measures was assessed in 491 European herds. Experts allocated a welfare score (from 0 to 100) to 12 focus herds for which the prevalence of each welfare measure was benchmarked against all 491 herds. Quadratic models indicated a high correspondence between these subjective scores and the WI (R2 = 0.91). The WI allows both numerical (0–100) as a qualitative (“not classified” to “excellent”) evaluation of welfare. Although it is sensitive to those welfare issues that most adversely affect cattle welfare (as identified by EFSA), the WI should be accompanied with a disclaimer that lists adverse or favorable effects that cannot be detected adequately by the current selection of measures.
Published: 2021
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29. Echocardiographic findings on aortic stenosis: an observational, prospective, and multi-center registry

Author: Tomas Lapinskas, Didem Oguz, Elizabeta Srbinovska, Shehab Anwer, Erwan Donal, Irena Peovska Mitevska, Matteo Cameli, Lilit Baghdassarian, Laura Galian-Gay, Ciro Santoro, Raluca Elena Dulgheru, Savvas Loizos, Julien Magne, Julia Grapsa, Department of Cardiology, University Heart Center, University Hospital Zurich, Başkent University Hospital [Adana, Turkey], Department of Cardiovascular Medicine, Mayo Clinic, Hospital General Universitari Vall dHebron, University of Skopje, Yerevan State Medical University, GIGA Cardiovascular Sciences [Liège, Belgium] (Department of Cardiology), University Hospital Sart Tilman [Liège, Belgium]-Heart Valve Clinic [Liège, Belgium], Lithuanian University of health Sciences [Kaunas], University of Naples Federico II, Hammersmith Hospital NHS Imperial College Healthcare, Università degli Studi di Siena = University of Siena (UNISI), Barts Health NHS Trust [London, UK], Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de cardiologie [CHU Limoges], CHU Limoges, Centre Hospitalier Universitaire de Rennes (CHU Rennes), Clinical sciences, Anwer, S., Oguz, D., Galian-Gay, L., Peovska Mitevska, I., Baghdassarian, L., Dulgheru, R., Lapinskas, T., Santoro, C., Loizos, S., Cameli, M., Srbinovska, E., Grapsa, J., Magne, J., and Donal, E.
Subjects: medicine.medical_specialty, Aortic Valve Stenosis/diagnostic imaging, left ventricle, 030204 cardiovascular system & hematology, right ventricle, Severity of Illness Index, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, strain, Internal medicine, Medicine, Humans, echocardiography, Radiology, Nuclear Medicine and imaging, In patient, 030212 general & internal medicine, Low gradient, Prospective Studies, Registries, Advanced and Specialized Nursing, business.industry, aortic stenosis, Stroke Volume, General Medicine, Aortic Valve Stenosis, aortic stenosi, medicine.disease, Stenosis, volumes, Aortic valve stenosis, Cardiology, cardiovascular system, Observational study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, low flow low gradient, Cardiology and Cardiovascular Medicine, business, Safety Research, Follow-Up Studies
Abstract: Background: The aim of this aortic stenosis registry was to investigate the changes of routine echocardiographic indices and strain in patients with moderate-to-severe aortic stenosis over a 6-month follow-up period. Methods: Our aortic stenosis registry is observational, prospective, multicenter registry of nine countries, with 197 patients with aortic valve area less than 1.5 cm2. The enrolment took place from January to August 2017. We excluded patients with uncontrolled atrial arrhythmias, pulmonary hypertension or cardiomyopathies, as well as those with hemodynamically significant valvular disease other than aortic stenosis. We included patients who did not require intervention and who had a complete follow-up study. Results: In patients with preserved ejection fraction, left ventricular mass has significantly increased between baseline and follow-up studies (218 ± 34 grams vs 253 ± 29 grams, p = 0.02). However, when indexed to body surface area, there was no significant difference. Left ventricular global longitudinal strain significantly decreased (-19.7 ± -4.8 vs (-16.4 vs -3.8, p = 0.01). Left atrial volume was significantly higher at follow-up (p = 0.035). Right ventricular basal diameter and mid-cavity diameter were greater at the follow-up (p = 0.04 and p = 0.035, respectively). Patients with low-flow low-gradient aortic stenosis had significantly lower global longitudinal strain (-12.3% ± -3.9% vs -19.7% ± -4.8%, p = 0.01). Conclusion: Left atrial dilatation is one of the first changes to take place in low-flow low-gradient aortic stenosis patients even when left ventricular dimensions and function remains intact. Global longitudinal strain is an important determinant of left ventricular systolic and diastolic dysfunction and right ventricular function is an important parameter of aortic stenosis assessment. Accordingly, our registry has further shed the light on these indices role as multisite follow-up of aortic stenosis.
Published: 2021
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30. General practitioners' deprescribing decisions in older adults with polypharmacy: a case vignette study in 31 countries

Author: Birgitta Weltermann, Shlomo Vinker, Radost Assenova, Jacobijn Gussekloo, Vanja Lazic, Lieve Peremans, Daiana Bonfim, Kathryn Hoffmann, Péter Torzsa, Raquel Gomez Bravo, Sandra Gintere, Aristea Missiou, Tuomas Koskela, Rosy Tsopra, Martin Sattler, Claire Collins, Marija Petek Šter, Donata Kurpas, Nicolas Rodondi, Kasper L. Johansen, Petra Bomberová Kánská, Liina Pilv, Ferdinando Petrazzuoli, Heidrun Lingner, Christian D Mallen, Hans Thulesius, Sophie Mantelli, Rosalinde K. E. Poortvliet, Zsofia Rozsnyai, Milly A. van der Ploeg, Emily Reeve, Katharine Wallis, Sven Streit, Sanda Kreitmayer Pestic, Gindrovel Dumitra, Markus Bleckwenn, Victoria Tkachenko, Rita P. A. Viegas, Katharina Tabea Jungo, Clare Luymes, Biljana Gerasimovska Kitanovska, Jungo, Katharina Tabea, Mantelli, Sophie, Rozsnyai, Zsofia, Missiou, Aristea, Reeve, Emily, Streit, Sven, University of Bern, University of Ioannina, Sts. Cyril and Methodius University, University Hospital [Essen, Germany], University of Bonn Medical Centre [Bonn], Keele University [Keele], Irish College of General Practitioners [Dublin, Irlande] (ICGP), Hospital Israelita Albert Einstein [São Paulo, Brazil], Wroclaw Medical University [Wrocław, Pologne], Lund University [Lund], Romanian Society of Family Medicine [Bucharest, Romania] (RSFM), Linnaeus University, Hannover Medical School [Hannover] (MHH), Danish College of General Practitioners [Copenhagen, Denmark] (DCGP), University of Queensland [Brisbane], University of Vienna [Vienna], University of Antwerp (UA), University of Tartu, University of Ljubljana, University of Leipzig [Leipzig, Allemagne], Societé Scientifique Luxembourgois en Medicine generale [Luxembourg City, Luxembourg] (SSLMG), Leiden University Medical Center (LUMC), Semmelweis University [Budapest], Faculty of Medicine in Hradec Kralove [Republique Tchèque], Charles University [Prague] (CU), Tel Aviv University [Tel Aviv], Faculty of Medicine [Plovdiv, Bulgarie], University of Luxembourg [Luxembourg], NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Univerzitet u Tuzli [Tuzla, Bosnie-Herzégovine], Riga Stradins University (RSU), University of Tampere [Finland], Dom zdravlja Zagreb - Centar [Zagreb, Croatia], Shupyk National Medical Academy of Postgraduate Education [Kyiv, Ukraine] (SNMAPE), University of South Australia [Adelaide], Dalhousie University [Halifax], Public Health Sciences, Ss. Cyril and Methodius University in Skopje (UKIM), Universität Bonn = University of Bonn, Wrocław Medical University, Romanian Society of Family Medicine [Bucharest] (RSFM), Danish College of General Practitioners [Copenhagen] (DCGP), Medizinische Universität Wien = Medical University of Vienna, Universität Leipzig, Societé Scientifique Luxembourgois en Medicine generale [Luxembourg City] (SSLMG), Universiteit Leiden, Semmelweis University of Medicine [Budapest], University of Hradec Králové, Tel Aviv University (TAU), Medical University of Plovdiv, École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Tampere University Hospital, Dom zdravlja Zagreb - Centar [Zagreb], Shupyk National Medical Academy of Postgraduate Education [Kiev] (SNMAPE), Malbec, Odile, Leipzig University, Tampere University, Clinical Medicine, and Primary Health Care
Subjects: Activities of daily living, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Medizin, Case vignette, Old age, Disease, lcsh:Geriatrics, 030204 cardiovascular system & hematology, RC952, MESH: Aged, 80 and over, Deprescriptions, 0302 clinical medicine, deprescribing, Activities of Daily Living, Medicine, 030212 general & internal medicine, Primary health care, MESH: Aged, Aged, 80 and over, Geriatrics, Rehabilitation, MESH: Polypharmacy, 3142 Public health care science, environmental and occupational health, MESH: General Practitioners, 3. Good health, [SDV] Life Sciences [q-bio], Female, Deprescribing, Research Article, medicine.medical_specialty, multimorbidity, 610 Medicine & health, 3121 Internal medicine, MESH: Multimorbidity, Odds, 03 medical and health sciences, General Practitioners, 360 Social problems & social services, Humans, polypharmacy, Aged, old age, Polypharmacy, MESH: Humans, business.industry, MESH: Activities of Daily Living, Public Health, Environmental and Occupational Health, Multimorbidity, MESH: Deprescriptions, primary health care, lcsh:RC952-954.6, Family medicine, 3111 Biomedicine, Human medicine, Geriatrics and Gerontology, business, MESH: Female
Abstract: Background General practitioners (GPs) should regularly review patients’ medications and, if necessary, deprescribe, as inappropriate polypharmacy may harm patients’ health. However, deprescribing can be challenging for physicians. This study investigates GPs’ deprescribing decisions in 31 countries. Methods In this case vignette study, GPs were invited to participate in an online survey containing three clinical cases of oldest-old multimorbid patients with potentially inappropriate polypharmacy. Patients differed in terms of dependency in activities of daily living (ADL) and were presented with and without history of cardiovascular disease (CVD). For each case, we asked GPs if they would deprescribe in their usual practice. We calculated proportions of GPs who reported they would deprescribe and performed a multilevel logistic regression to examine the association between history of CVD and level of dependency on GPs’ deprescribing decisions. Results Of 3,175 invited GPs, 54% responded (N = 1,706). The mean age was 50 years and 60% of respondents were female. Despite differences across GP characteristics, such as age (with older GPs being more likely to take deprescribing decisions), and across countries, overall more than 80% of GPs reported they would deprescribe the dosage of at least one medication in oldest-old patients (> 80 years) with polypharmacy irrespective of history of CVD. The odds of deprescribing was higher in patients with a higher level of dependency in ADL (OR =1.5, 95%CI 1.25 to 1.80) and absence of CVD (OR =3.04, 95%CI 2.58 to 3.57). Interpretation The majority of GPs in this study were willing to deprescribe one or more medications in oldest-old multimorbid patients with polypharmacy. Willingness was higher in patients with increased dependency in ADL and lower in patients with CVD.
Published: 2021
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31. Improving the Quality of Oocytes with the Help of Nucleolotransfer Therapy

Author: Martin Morovic, Florina Popovska Percinic, Frantisek Strejcek, Jozef Laurincik, Amélie Bonnet-Garnier, Michal Benc, Alexandra Bartkova, Ahmed Gad, Matej Murin, Faculty of Natural Sciences Constantine the Philosopher University in Nitra, Institute of Animal Physiology and Genetics of the Czech Academy of Sciences (IAPG / CAS), Czech Academy of Sciences [Prague] (CAS), Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), École nationale vétérinaire d'Alfort (ENVA), and St. Cyril and St. Methodius University in Skopje
Subjects: 0301 basic medicine, zygote, Somatic cell, Nucleolus, nucleolotransfer, lcsh:Medicine, lcsh:RS1-441, Pharmaceutical Science, Ribosome biogenesis, embryo, Review, Biology, Genome, lcsh:Pharmacy and materia medica, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, nucleolus, oocyte, [SDV.BDD]Life Sciences [q-bio]/Development Biology, 030219 obstetrics & reproductive medicine, Zygote, lcsh:R, Oocyte, Embryonic stem cell, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Molecular Medicine, Nucleus
Abstract: International audience; The nucleolus is an important nucleus sub-organelle found in almost all eukaryotic cells. On the one hand, it is known as a differentiated active site of ribosome biogenesis in somatic cells, but on the other hand, in fully grown oocytes, zygotes, and early embryos (up to the major embryonic genome activation), it is in the form of a particular homogenous and compact structure called a fibrillar sphere. Nowadays, thanks to recent studies, we know many important functions of this, no doubt, interesting membraneless nucleus sub-organelle involved in oocyte maturation, embryonic genome activation, rRNA synthesis, etc. However, many questions are still unexplained and remain a mystery. Our aim is to create a comprehensive overview of the recent knowledge on the fibrillar sphere and envision how this knowledge could be utilized in further research in the field of biotechnology and nucleolotransfer therapy.
Published: 2021
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32. La stylisation dans les traductions du Nouveau Testament en langue vernaculaire macédonienne moderne, au XIXe siècle

Author: Borče Arsov and Ss. Cyril and Methodius University in Skopje
Subjects: Nouveau Testament, Translation, traduction, Stylization, stylisation, media_common.quotation_subject, Macédonien vernaculaire, 19th century, Vernacular, Macedonian, Art, language.human_language, Macedonian vernacular, New Testament, language, XIXe siècle, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, Humanities, media_common
Abstract: The Konikovo Gospel (KG), The Kulakia Gospel (KuG) and The Boboščica Gospel (BG) are among the first known translations of the New Testament in Macedonian vernacular dating from the 19th century. They are all written in Greek alphabet. In this article we present the most specific examples demonstrating a stylization tendency towards a wider dialectal base and/or towards a more elevated style. The most important conclusion is that of all the analysed gospels the most stylized text is the oldest among them, the KG (1852), especially its second hand. The stylization steps are less common for the KuG (1860) and even less for the BG (1880). It is possible to say that the texts analyzed in this paper, together with the other translations of the New Testament in Macedonian vernacular from the 18th and the 19th centuries, open, more or less, a clear path towards the formation of one Biblical language, leading to the translations of the Bible in contemporary Macedonian standard language in 1976, 2003 and 2007., L’Évangéliaire de Konikovo (EK), l’Évangéliaire de Kulakia (EKu) et l’Évangéliaire de Boboščica (EB) sont les premières traductions sérieuses duNouveau Testament en langue vernaculaire macédonienne du XIXe siècle. Ils sont tous écrits en alphabet grec. Cet article présente les exemples les plus spécifiques des textes montrant une tendance à la stylisation par élargissement de la base dialectale et/ou par élévation du style. De toutes les traductions des évangiles en langue vernaculaire macédonienne de Macédoine du sud du XIXe siècle ayant été analysées, on peut conclure que le texte le plus stylisé et en même temps le plus ancien est celui de l’EK (1852), et surtout sa deuxième main. Les démarches de stylisation sont moins perceptibles dans le texte de l’EKu (1860) et encore moins perceptibles dans celui de l’EB (1880). On peut dire que les traductions analysées, mais aussi les autres traductions du Nouveau Testament en langue vernaculaire macédonienne de Macédoine du sud des XVIIIe et XIXe siècles ouvrent, plus ou moins, une voie vers la formation d’une langue biblique, voie aboutissant aux traductions de la Bible en macédonien standard contemporain en 1976, 2003 et 2007.
Published: 2021

33. Existence and Quality of Data on Control Programs for EU Non-regulated Cattle Diseases: Consequences for Estimation and Comparison of the Probability of Freedom From Infection

Author: Rapaliute, Egle, van Roon, Annika, van Schaik, Gerdien, Santman-Berends, Inge, Koleci, Xhelil, Mincu, Madalina, Gethmann, J��rn, Conrady, Beate, Knific, Tanja, Hodnik, Jaka Jakob, Berezowski, John, Carmo, Luis Pedro, Madouasse, Aur��lien, Tarpai, Attila, Gerilovych, Anton, Malakauskas, Alvydas, Sekovska, Blagica, Fourichon, Christine, Kalaitzakis, Emmanouil, Roch, Franz-Ferdinand, Houe, Hans, Dudek, Katarzyna, M��tus, Kerli, ��zsv��ri, L��szl��, Costa, Lina, Guelbenzu-Gonzalo, Maria, Henry, Madeleine K, Alishani, Mentor, Pozzato, Nicola, Hopp, Petter, Juste, Ramon, Strain, Sam, Mandelik, Rene, Vil��ek, ��tefan, Autio, Tiina, Tamminen, Lena-Mari, Faverjon, C��line, Lithuanian University of health Sciences [Kaunas], Utrecht University [Utrecht], GD Animal Health [Deventer, the Netherlands], Agricultural University of Tirana, Research-Development Institute for Bovine, Partenaires INRAE, Friedrich-Loeffler-Institut (FLI), University of Veterinary Medicine [Vienna] (Vetmeduni), Complexity Science Hub Vienna (CSHV), IT University of Copenhagen, University of Ljubljana, University of Bern, Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Norwegian Veterinary Institute [Oslo], National Scientific Center, Ss. Cyril and Methodius University in Skopje, Aristotle University of Thessaloniki, National Veterinary Research Institute [Pulawy, Pologne] (NVRI), Estonian University of Life Sciences (EMU), University of Veterinary Medicine [Budapest, Hungary], Politécnico de Portalegre = Polytechnic Institute of Portalegre, Animal Health Ireland (AHI), Scotland's Rural College (SRUC), University of Prishtina, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Neiker-Instituto Vasco de Investigación y Desarrollo Agrario (SPAIN), Instituto Vasco de Investigación y Desarrollo Agrario [Derio] (NEIKER), Animal Health and Welfare Northern Ireland, University of Veterinary Medicine and Pharmacy [Košice, Slovakia], Finnish Food Authority, Swedish University of Agricultural Sciences (SLU), Ausvet Europe, This study was part of SOUND control COST Action (CA17110), funded by Horizon 2020 Framework Program of the European Union and COST—European Cooperation in Science & Technology., FAH Evidence based Veterinary Medicine, dFAH AVR, FAH veterinaire epidemiologie, and Dep Gezondheidszorg Landbouwhuisdieren
Subjects: output-based, Animal health data, Non-regulated diseases, 630 Agriculture, [SDV]Life Sciences [q-bio], control programs, proof of freedom, Output-based, Clinical Science, veterinary(all), Control programs, Proof of freedom, cattle, non-regulated diseases, Veterinary Science, Cattle, animal health data, Original Research
Abstract: International audience; Some European countries have successfully implemented country-specific control programs (CPs) for infectious cattle diseases that are not regulated or are regulated only to a limited extent at the European Union (EU) level. Examples of such diseases include bovine viral diarrhea (BVD), infectious bovine rhinotracheitis (IBR), and Johne's disease (JD). The CPs vary between countries in the design and quality of collected data as well as methods used to detect infection and estimate prevalence or probability of freedom from infection. Differences in disease status between countries and non-standardized approaches to assess freedom from infection pose a risk for countries with CPs for non-regulated diseases as infected animals may influence the progress of the disease control or eradication program. The implementation of output-based standards allows estimation and comparison of the probability of freedom for non-regulated cattle diseases in European countries. The aim of the current study was to assess the existence and quality of data that could be used for estimating freedom from infection in European countries. The online data collection tool was sent to 32 countries participating in the SOUND control COST Action and was completed by 24 countries. Data on cattle demographics and data from CPs of IBR and BVD exist in more than 50% of the response countries. However, data describing risk factors and CP of JD was reported as existing in
Published: 2021
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34. Analysis of the Noise Impact in Urban Area in the City of Skopje

Author: Domazetovska, Simona, Anachkova, Maja, Gavriloski, Viktor, Petreski, Zlatko, and Ss. Cyril and Methodius University in Skopje
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], Subjective Analysis, Questionnaire, Noise Measurements, Environmental Noise, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; The twenty-first century noise exposure is a major public health problem in the general living environment, requiring effective noise measurements and analysis for public health protection. Noise pollution in the urban environments is becoming increasingly common and it has potential to harmfully impact on people?s health and decrease the overall productivity. The parameters that disturb the quality of life, such as annoyance is a serious problem that needs to be solved. Skopje, as the capital of North Macedonia, is a city that faces problem with the environmental noise that causes different forms of health problems. In this work, a methodology for choosing pilot area and analyzing the noise pollution in that area through objective and subjective point of view is presented. The chosen pilot area of interest is a place called ?Debar Maalo? located in the city center, place with lots of inhabitants, visitors and surrounded with four main streets that are really frequent. Measurement for the noise levels were carried out using 1st class hand-held device, from which the results indicated increased noise pollution. In order to confirm these measurements, as well do analysis from subjective point of view, a questionnaire was conducted, showing that the population is disturbed by the increased noise levels. A general questionnaire was applied to a sample of 93 inhabitants, employees and visitors in this pilot area. The results show that the sound caused from vehicles and engines that drive at high speed are the most annoying sound from the urban noise sources. This study is a base for further research of the bad influence of the noise and its reduction and prevention in order to clarify this complex area.
Published: 2020
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35. NOISE EXPOSURE LEVEL DETECTION USING THE INTERNET OF THINGS (IoT) CONCEPT

Author: Anachkova, Maja, Domazetovska, Simona, Petreski, Zlatko, Gavriloski, Viktor, and Ss. Cyril and Methodius University in Skopje
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], noise exposure, Internet of Things, noise level, LoRaWAN, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; The intense globalization, the steady growth in population and the changes in infrastructure in the last decade have caused multiple environmental problems and negative environmental changes in the large cities. One of the most worrying problems that occurs in overpopulated and frequent urban cities is the problem of increased noise levels which can seriously affect human health. In the city of Skopje, as the capital of the Republic of North Macedonia, except for a few short-term measurements conducted by state institutions, no other measures have been taken to protect the citizens from the noise pollution. This work presents an environmentally sustainable solution based on an Internet of Things (IoT) platform in the city of Skopje for the purpose of 24-hour monitoring of the level of noise in several measuring stations in the city. The final goal of this platform is to serve as a monitoring portal and a credible source for an early warning system of increased noise levels in the city. This paper focuses on explaining the sensor design as well as the locations and functionality of the sensor network, providing information about the noise levels on different locations in Skopje. The data from the sensor network and obtained results in terms of understanding the noise pollution in Skopje are discussed.
Published: 2020
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36. Wireless Acoustic Low-cost Sensor Network for Urban Noise Monitoring

Author: Domazetovska, Simona, Anachkova, Maja, Gavriloski, Viktor, Petreski, Zlatko, and Ss. Cyril and Methodius University in Skopje
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], Internet of Things, Smart City, Low-cost Acoustic Sensors, Urban noise, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; The concept of Smart Cities and Internet of things for monitoring of environmental parameters is trendy area of research that has attracted scientific attention during the last decade. Amongst the several pollutant that have to be faced on a daily basis, the noise pollution is one of the most widely known emerging and challenging problem in all large metropolitan areas, affecting the health of citizens in multiple ways. Recent technologies of low- cost and low-power devices allowed researchers to develop monitoring devices for deploying Wireless Sensor Networks (WSN) with a higher granularity than the traditional handheld analyzers, allowing massive noise monitoring. This paper presents prototyping of a low-cost acoustic sensor based on the STM32 platform for noise monitoring and analysis. The accuracy of the sensor is configured by comparing the results with professional handheld analyzer through calibration test. The acoustic sensor developed in this paper aims to be an appropriate replacement for traditional handheld SPL devices in that it possesses the same output of the sound pressure level and is also provides a continuous and autonomous data acquisition. Through this deployment it was demonstrated that the overall trends in urban noise can be observed and better understood with higher granularity network that allows continuous measurements, thus allowing gathering information that could help the citizens and the urban planners to improve city designs in order to accommodate the rapid urban growth and sustain the overall quality of life.
Published: 2020
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37. Urban noise mapping: The impact of traffic noise level in the environmental noise pollution

Author: Anachkova, Maja, Domazetovska, Simona, Petreski, Zlatko, Gavriloski, Viktor, and Ss. Cyril and Methodius University in Skopje
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], urban noise mapping, noise exposure, traffic noise pollution, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; The European Union proposes noise protection measures adopted in accordance with European legislation, emphasizing environmental noise pollution as an important environmental problem. The legislation imposes European Directive 2002/49/EC, which aims to establish a common basis for addressing noise problems in Europe through noise maps which are a powerful tool for controlling the population exposure to environmental noise. In this paper, a noise map generation based on using the vehicle flows on four boulevards that enclose a living area in the center of Skopje, the capital city of North Macedonia is described. For this purpose, statistics on the flow of vehicles on the boulevards are provided by Traffic Management and Control Center. The noise simulations were created using the NMPB Routes 96 as noise propagation model and the IMMI Software as simulation software. This initial map was additionally upgraded and calibrated by performing short-term measurements at the intersections of these boulevards in order to differentiate the traffic noise pollution from the environmental noise. The possibility of having a map representation of traffic noise allowed for a more accurate view of the actual environmental noise situation, determining more quickly the causes of high noise levels and, consequently, any mitigation action required.
Published: 2020
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38. Aging at Work: A Review of Recent Trends and Future Directions

Author: Sabina Baraković, Petre Lameski, Jasmina Barakovic Husic, Nuno M. Garcia, Francisco Jose Melero, Eftim Zdravevski, Petra Maresova, Vladimir Trajkovik, Ivan Chorbev, Ondrej Krejcar, Saints Cyril and Methodius University in Skopje (North Macedonia), and Fondo Europeo de Desarrollo Regional (FEDER)
Subjects: aging at work, Aging, Aging at work, Population ageing, 6109.03 Planificación y Evaluación Puestos de Trabajo, Health, Toxicology and Mutagenesis, growth, Legislation, deficit, lcsh:Medicine, Review, Growth, legislation, Healthy Aging, 03 medical and health sciences, 0302 clinical medicine, Political science, Discrimination, Humans, 030212 general & internal medicine, Productivity, Aged, Deficit, Retirement, Assistance, Successful aging, business.industry, lcsh:R, Public Health, Environmental and Occupational Health, Public relations, Private sector, 030210 environmental & occupational health, assistance, Policy, Aging in the American workforce, Work (electrical), 52 Demografía, Workforce, business, discrimination, policy
Abstract: Demographic data suggest a rapid aging trend in the active workforce. The concept of aging at work comes from the urgent requirement to help the aging workforce of the contemporary industries to maintain productivity while achieving a work and private life balance. While there is plenty of research focusing on the aging population, current research activities on policies covering the concept of aging at work are limited and conceptually different. This paper aims to review publications on aging at work, which could lead to the creation of a framework that targets governmental decision-makers, the non-governmental sector, the private sector, and all of those who are responsible for the formulation of policies on aging at work. In August 2019 we searched for peer-reviewed articles in English that were indexed in PubMed, IEEE Xplore, and Springer and published between 2008 and 2019. The keywords included the following phrases: “successful aging at work”, “active aging at work”, “healthy aging at work”, “productive aging at work”, and “older adults at work”. A total of 47,330 publications were found through database searching, and 25,187 publications were screened. Afterwards, 7756 screened publications were excluded from the further analysis, and a total of 17,431 article abstracts were evaluated for inclusion. Finally, further qualitative analysis included 1375 articles, of which about 24 are discussed in this article. The most prominent works suggest policies that encourage life-long learning, and a workforce that comprises both younger and older workers, as well as gradual retirement. V.T., E.Z., I.C. and P.L. acknowledge the support of Faculty of Computer Science and Engineering, Ss. Cyril and Methodius University in Skopje, North Macedonia. In addition, this manuscript is funded by FCT/MEC through portuguese national funds and when applicable co-funded by FEDER—PT2020 partnership agreement under the project UIDB/EEA/50008/2020 (Este trabalho é financiado pela FCT/MEC através de fundos nacionais e quando aplicável cofinanciado pelo FEDER, no âmbito do Acordo de Parceria PT2020 no âmbito do projeto UIDB/EEA/50008/2020). This manuscript is based upon work from COST Action IC1303-AAPELE-Architectures, Algorithms, and Protocols for Enhanced Living Environments and COST Action CA16226-SHELD-ON-Indoor living space improvement: Smart Habitat for the Elderly, supported by COST (European Cooperation in Science and Technology). COST is a funding agency for research and innovation networks. Our actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. More information in www.cost.eu. Based on CA16226 project, LTC18035 INTER COST was proposed for national funding support of COST ACTION Framework by MEYS, Czech Republic. This work was also supported in part by the project (2020/2206), Grant Agency of Excellence, University of Hradec Kralove, Faculty of Informatics and Management, Czech Republic.
Published: 2020

39. Evaluation of Suppressed Mite Reproduction (SMR) Reveals Potential for Varroa Resistance in European Honey Bees (Apis mellifera L.)

Author: Fanny Mondet, Gianluigi Bigio, Małgorzata Bieńkowska, Justinas Kretavicius, B. Basso, Fani Hatjina, Aleksandar Uzunov, Melanie Parejo, Cecilia Costa, Marin Kovačić, Eliza Cauia, Bertrand Servin, Per Kryger, Bjørn Dahle, Sreten Andonov, Beata Panasiuk, Valentina Cebotari, Ralph Büchler, Marina D. Meixner, Marica Maja Dražić, M. Alice Pinto, Jerzy Wilde, Ana S. Lima, Abeilles et Environnement (AE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UMT PrADE, Agroscope, University of the Basque Country [Bizkaia] (UPV/EHU), LLH Bieneninstitut Kirchhain, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA), Aarhus University [Aarhus], FZNH, Departement of Animal Biotechnology, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ITSAP-Institut de l'Abeille, ITSAP, Research Institute of Horticulture, Aspromiele, Regional Association of Honey Producers, Institute for Beekeeping Research and Development, Partenaires INRAE, Institute of Zoology, Academy of Sciences of Moldova (ASM), Norwegian Beekeepers Association, Norwegian University of Life Sciences (NMBU), Ministry of Agriculture [Zagreb, Croatia], Hellenic Agricultural Organization Demeter (HAO Demeter), Josip Juraj Strossmayer University of Osijek, National Bee Breeding Association, Centro de Estudos do Ambiente e do Mar (CESAM)/Museu Nacional de História Natural, Universidade de Lisboa (ULISBOA), Centro de Investigação de Montanha [Bragança, Portugal] (CIMO), Instituto Politécnico de Bragança, Ss. Cyril and Methodius University in Skopje, and University of Warmia and Mazury in Olsztyn
Subjects: 0106 biological sciences, Varroa, Zoology, selection, Selective breeding, 010603 evolutionary biology, 01 natural sciences, resistance, Animal and Dairy Science, Mite, honey bee, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Destructor, lcsh:Science, biology, [SDV.BA]Life Sciences [q-bio]/Animal biology, fungi, food and beverages, SMR (suppressed mite reproduction), Honey bee, biology.organism_classification, Breed, respiratory tract diseases, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, varroa, breeding, 010602 entomology, Microbiology (Microbiology in the medical area to be 30109), Insect Science, Varroa destructor, Trait, behavior and behavior mechanisms, lcsh:Q, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract: Simple Summary The miteVarroa destructorrepresents a great threat to honey bees and the beekeeping industry. The opportunity to select and breed honey bees that are naturally able to fight the mite stands a sustainable solution. This can be achieved by evaluation of the failure of mite reproduction (SMR, suppressed mite reproduction). We conducted a large European experiment to assess the SMR trait in different populations of honey bees spread over 13 different countries, and representing different honey bee populations. The first goal was to standardize and validate the SMR evaluation method, and then to compare the SMR trait between the different populations. Our results indicate that it is necessary to examine at least 35 brood cells infested by a single mite to reliably estimate the SMR score of any given colony. Several colonies from our dataset display high SMR scores, indicating that this trait is present within the European honey bee populations. No major differences could be identified between countries for a given population, or between populations in different countries. This study shows the potential to increase selection efforts to breedV. destructorhoney bee resistant populations. In the fight against theVarroa destructormite, selective breeding of honey bee (Apis melliferaL.) populations that are resistant to the parasitic mite stands as a sustainable solution. Selection initiatives indicate that using the suppressed mite reproduction (SMR) trait as a selection criterion is a suitable tool to breed such resistant bee populations. We conducted a large European experiment to evaluate the SMR trait in different populations of honey bees spread over 13 different countries, and representing different honey bee genotypes with their local mite parasites. The first goal was to standardize and validate the SMR evaluation method, and then to compare the SMR trait between the different populations. Simulation results indicate that it is necessary to examine at least 35 single-infested cells to reliably estimate the SMR score of any given colony. Several colonies from our dataset display high SMR scores indicating that this trait is present within the European honey bee populations. The trait is highly variable between colonies and some countries, but no major differences could be identified between countries for a given genotype, or between genotypes in different countries. This study shows the potential to increase selective breeding efforts ofV. destructorresistant populations.
Published: 2020
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40. Zonotope-based interval estimation for discrete-time linear switched systems

Author: Zhang, Wenhan, Wang, Zhenhua, Raissi, Tarek, Dinh, Thach Ngoc, Dimirovski, Georgi, Harbin Institute of Technology (HIT), CEDRIC. Traitement du signal et architectures électroniques (CEDRIC - LAETITIA), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and Ss. Cyril and Methodius University in Skopje
Subjects: interval estimation, switched systems, observer design, Zonotopic techniques, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract: International audience; This paper is concerned with the state interval estimation for discrete-time linear switched systems affected by unknown but bounded disturbances and measurement noises. A novel interval estimation method is proposed by integrating robust observer design with zonotopic techniques. By introducing L ∞ technique into observer design, the proposed method is effective in attenuating the influence of unknown disturbances and noises, and improving the accuracy of interval estimation. Based on the designed observer, the state interval estimation can be obtained by using zonotopic analysis. Finally, the feasibility and effectiveness of the proposed method are illustrated by numerical simulations.
Published: 2020

41. Two decades of forest-related legislation changes in European countries analysed from a property rights perspective

Author: Nichiforel, Liviu, Deuffic, Philippe, Thorsen, Bo Jellesmark, Weiss, Gerhard, Hujala, Teppo, Keary, Kevin, Lawrence, Anna, Avdibegović, Mersudin, Dobšinská, Zuzana, Feliciano, Diana, Gorriz-Mifsud, Elena, Hoogstra-Klein, Marjanke, Hrib, Michal, Jarský, Vilém, Jodłowski, Krzysztof, Lukmine, Diana, Pezdevšek Malovrh, Špela, Nedeljković, Jelena, Nonić, Dragan, Krajter Ostoić, Silvija, Pukall, Klaus, Rondeux, Jacques, Samara, Theano, Sarvašová, Zuzana, Scriban, Ramona Elena, Šilingienė, Rita, Sinko, Milan, Stojanovska, Makedonka, Stojanovski, Vladimir, Stoyanov, Todor, Teder, Meelis, Vennesland, Birger, Wilhelmsson, Erik, Wilkes-Allemann, Jerylee, Živojinović, Ivana, Bouriaud, Laura, Universitatea Stefan cel Mare Suceava (USU), Environnement, territoires et infrastructures (UR ETBX), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Center Macroecology, Evolution and Climate, Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Universität für Bodenkultur Wien [Vienne, Autriche] (BOKU), Natural Resources Institute Finland (LUKE), University of Joensuu, Department of Agriculture Food and the Marine, Dublin, University of the Highlands and Islands (UHI), University of Sarajevo, UNIVERZITET U SARAJEVU, Faculty of Forestry, Zvolen, School of Biological Sciences, University of Aberdeen, Aberdeen, UK, European Forest Institute = Institut Européen de la Forêt = Euroopan metsäinstituutti (EFI), Wageningen University and Research [Wageningen] (WUR), Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague (CZU), Forest Research Institute, Sekocin Stary, Institut of Forestry, Girionys, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia, University of Belgrade [Belgrade], Croatian Forest Research Institute, Jastrebarsko, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Gestion des ressources forestières et des milieux naturels, Faculté Universitaire des Sciences Agronomiques de Gembloux, Forest Research Institute of Thessaloniki, Vassilika, National Forest Centre, Zvolen, University Stefan cel Mare of Suceava (USU), Institute of Forestry, Girionys, University of Ljubljana, University of Skopje, Bulgarian Academy of Sciences (BAS), Estonian University of Life Sciences (EMU), Swedish University of Agricultural Sciences (SLU), European Forest Inst Cent East & South East Europ, and University of Vienna [Vienna]
Subjects: Private ownership, Economics, Forest Science, Institutional changes, Forest governance, Property rights, PRIF, [SHS.SCIPO]Humanities and Social Sciences/Political science, [SHS]Humanities and Social Sciences, Law (excluding Law and Society)
Abstract: In the last two decades, attention on forests and ownership rights has increased in different domains of international policy, particularly in relation to achieving the global sustainable development goals. This paper looks at the changes in forest-specific legislation applicable to regular productive forests, across 28 European countries. We compare the legal framework applicable in the mid-1990s with that applicable in 2015, using the Property Rights Index in Forestry (PRIF) to measure changes across time and space. The paper shows that forest owners in most western European countries already had high decision-making power in the mid-1990s, following deregulation trends from the 1980s; and for the next two decades, distribution of rights remained largely stable. For these countries, the content and direction of changes indicate that the main pressure on forest-focused legislation comes from environmental discourses (e.g. biodiversity and climate change policies). In contrast, former socialist countries in the mid-1990s gave lower decision-making powers to forest owners than in any of the Western Europe countries; over the next 20 years these show remarkable changes in management, exclusion and withdrawal rights. Nevertheless, with the exception of Baltic countries which have moved towards the western forest governance system, most of the former socialist countries still maintain a state-centred approach in private forest management. Despite this diverse setting of property rights, there is no longer a clear line between western and former socialist countries with respect to the national governance systems used to address private forest ownership. Overall, most of the changes we identified in the last two decades across Europe were recorded in the categories of management rights and exclusion rights. These changes reflect the general trend in European forest policies to expand and reinforce the landowners’ individual rights, while preserving minimal rights for other categories of forest users; and to make use of financial instruments when targeting policy goals related to the environmental discourse.
Published: 2020
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42. Summer brood interruption as integrated management strategy for effective Varroa control in Europe

Author: Borce Pavlov, Zlatko Puškadija, Mira Rogelj Jenko, Aleš Gregorc, J. Vallon, Antonio Nanetti, Draiusz Gerula, Denis Vojt, Marin Kovačić, Jorge Rivera-Gomis, Janez Prešern, Fani Hatjina, Valeria Malagnini, Nebojša Nedić, Marina D. Meixner, Jerzy Wilde, Giovanni Formato, Ralph Büchler, Marco Pietropaoli, Egoitz Galarza, Leonidas Charistos, Maja Ivana Smodiš Škerl, Aleksandar Uzunov, Landesbetrieb Landwirtschaft Hessen, Partenaires INRAE, Ss. Cyril and Methodius University in Skopje, Josip Juraj Strossmayer University of Osijek, Agricultural Institute of Slovenia, Agricultural Institute, Instituto Zooprofilattico Sperimentale del Lazio e della toscana 'M.Aleandri', Rome, Hellenic Agricultural Organization Demeter (HAO Demeter), PZ Eko-Pcela, Instituto Zooprofilatto Sperimentale des Lazio e della Toscana ' M. Aleandri', Iberian Bee Breeding Association (ERBEL), Research Institute of Horticulture, Division of apiculture, University of Maribor, Fondazione Edmund Mach - Edmund Mach Foundation [Italie] (FEM), University of Belgrade [Belgrade], instituto Zooprofilattico Sperimentale del Lazio e della Toscana 'M. Aleandri', University of Ljubljana, ITSAP-Institut de l'Abeille, ITSAP, Abeilles et Environnement (AE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Warmia and Mazury in Olsztyn, and Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA)
Subjects: 0106 biological sciences, Varroa mite, biotechnical control, brood interruption, colony losses, medicine.disease_cause, 01 natural sciences, Toxicology, 0404 agricultural biotechnology, parasitic diseases, Infestation, medicine, biology, [SDV.BA]Life Sciences [q-bio]/Animal biology, fungi, 04 agricultural and veterinary sciences, biology.organism_classification, 040401 food science, [SDE.ES]Environmental Sciences/Environmental and Society, Brood, 010602 entomology, Settore AGR/11 - ENTOMOLOGIA GENERALE E APPLICATA, Insect Science, behavior and behavior mechanisms, Varroa, Winter season
Abstract: Most Varroa induced colony losses occur during the autumn or winter season as a consequence of an elevated Varroa infestation level and an insufficient health status of the adult bees. Even with an initial low Varroa infestation in early spring, critical mite and virus infection levels can be reached before winter if colonies continuously rear brood throughout the whole season. To overcome this challenge, beekeepers can artificially interrupt brood production by suitable management procedures, depending on their type of beekeeping operation. To assess their efficacy, associated workload, and impact on colony development, different methods for brood interruption (queen caging with the combination of oxalic acid treatment, total brood removal, trapping comb technique) were tested during two seasons in 11 locations on 370 colonies in 10 European countries. A protocol was developed to standardize the methods’ application across different environmental conditions. The efficacy of queen caging depended on the mode of oxalic acid application and ranged from 48.16% to 89.57% mite removal. The highest efficacies were achieved with trickling a 4.2% solution (89.57%) and with the sublimation of 2 g of oxalic acid (average of 88.25%) in the broodless period. The efficacy of the purely biotechnical, chemical-free trapping comb and brood removal methods did not differ significantly from the queen caging groups. We conclude that a proper application of one of the described brood interruption methods can significantly contribute to an efficient Varroa control and to the production of honey bee products meeting the highest quality and food- safety standards.
Published: 2020
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43. First report of Plum pox virus strains M, D, and Rec infecting Prunus spp. in the Republic of North Macedonia

Author: Biljana Kuzmanovska, G. Thébaud, Rade Rusevski, M. Brevet, S. Dallot, Biologie et Génétique des Interactions Plante-Parasite (UMR BGPI), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Ss. Cyril and Methodius University in Skopje
Subjects: 0106 biological sciences, 0303 health sciences, Chlorosis, Pathogen detection, [SDV]Life Sciences [q-bio], Plant Science, Biology, 01 natural sciences, Virology, 03 medical and health sciences, Prunus, Phylogenetics, Plant virus, Pox virus, Agronomy and Crop Science, 030304 developmental biology, 010606 plant biology & botany
Published: 2020
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44. Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe

Author: Charlier, J., Rinaldi, L., Musella, V., Ploeger, H. W., Chartier, C., Vineer, H. Rose, Hinney, B., von Samson-Himmelstjerna, G., Băcescu, B., Mickiewicz, M., Mateus, T. L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Höglund, J., Morgan, E. R., Bartley, D. J., Claerebout, E., Klinische infectiologie en microb. lab., dI&I I&I-4, Martínez Valladares, María [0000-0002-3723-1895], Kreavet, Department of Veterinary Medicine and Animal Productions, 'Federico II' University of Naples Medical School, Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), Utrecht University [Utrecht], Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Liverpool, University of Veterinary Medicine [Vienna] (Vetmeduni), Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Spiru Haret University, Warsaw University of Life Sciences (SGGW), Polytechnic Institute of Viana do Castelo, Instituto de Saúde Pública da Universidade do Porto [Porto, Portugal] (ISPUP), Universidade do Porto, Departamento de Sanidad Animal, Instituto de Ganadería de Montaña, Consejo Superior de Investigaciones Científicas, VirtualVet, University of Haifa [Haifa], Ss. Cyril and Methodius University in Skopje, École Nationale de Médecine Vétérinaire de Sidi Thabet, Ministère de l’Agriculture, des Ressources Hydrauliques et de la Pêche Maritime [Tunisie], Lithuanian University of Health Sciences [Kaunas, Lithuania], Norwegian University of Life Sciences (NMBU), Swedish University of Agricultural Sciences (SLU), Queen's University [Belfast] (QUB), Moredun Research Institute [Penicuik, UK] (MRI), Universiteit Gent = Ghent University [Belgium] (UGENT), European Cooperation in Science and Technology, Livestock Helminth Research Alliance, Biotechnology and Biological Sciences Research Council (UK), Ministerio de Economía y Competitividad (España), Martínez Valladares, María, Klinische infectiologie en microb. lab., dI&I I&I-4, Charlier, J., Rinaldi, L., Musella, V., Ploeger, H. W., Chartier, C., Vineer, H. R., Hinney, B., von Samson-Himmelstjerna, G., Bacescu, B., Mickiewicz, M., Mateus, T. L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Hoglund, J., Morgan, E. R., Bartley, D. J., Claerebout, E., COMBAR, Charlier, J, Rinaldi, L, Musella, V, Ploeger, Hw, Chartier, C, Rose Vineer, H, Hinney, B, von Samson-Himmelstjerna, G, Băcescu, B, Mickiewicz, M, Mateus, Tl, Martinez-Valladares, M, Quealy, S, Azaizeh, H, Sekovska, B, Akkari, H, Petkevicius, S, Hektoen, L, Höglund, J, Morgan, Er, Bartley, Dj, Claerebout, E, and Instituto de Saúde Pública da Universidade do Porto
Subjects: [SDV]Life Sciences [q-bio], Resistance, Direct cost, Cattle Diseases, 0403 veterinary science, Indirect costs, Cost of Illness, Food Animals, Economic cost, Direct costs, Anthelmintic, Economic impact analysis, health care economics and organizations, 2. Zero hunger, Anthelmintics, 0303 health sciences, education.field_of_study, Goats, Ostertagia, 04 agricultural and veterinary sciences, 3. Good health, Europe, Dictyocaulus, Goat, Dictyocaulu, Fascioliasis, 040301 veterinary sciences, Population, Sheep Diseases, Biology, 03 medical and health sciences, Environmental health, parasitic diseases, Dictyocaulus Infections, Animals, education, Ostertagia Fasciola, Sheep, Domestic, Dairy cattle, 030304 developmental biology, Goat Diseases, Sheep, Food security, Fasciola hepatica, biology.organism_classification, Cattle, Economic costs, Fasciola, Animal Science and Zoology, Lungworm
Abstract: 12 páginas, 4 figuras, 4 tablas., We report a European wide assessment of the economic burden of gastrointestinal nematodes, Fasciola hepatica (common liver fluke) and Dictyocaulus viviparus (bovine lungworm) infections to the ruminant livestock industry. The economic impact of these parasitic helminth infections was estimated by a deterministic spreadsheet model as a function of the proportion of the ruminant population exposed to grazing, the infection frequency and intensity, the effect of the infection on animal productivity and mortality and anthelmintic treatment costs. In addition, we estimated the costs of anthelmintic resistant nematode infections and collected information on public research budgets addressing helminth infections in ruminant livestock. The epidemiologic and economic input data were collected from international databases and via expert opinion of the Working Group members of the European Co-operation in Science and Technology (COST) action COMbatting Anthelmintic Resistance in ruminants (COMBAR). In order to reflect the effects of uncertainty in the input data, low and high cost estimates were obtained by varying uncertain input data arbitrarily in both directions by 20 %. The combined annual cost [low estimate-high estimate] of the three helminth infections in 18 participating countries was estimated at € 1.8 billion [€ 1.0–2.7 billion]. Eighty-one percent of this cost was due to lost production and 19 % was attributed to treatment costs. The cost of gastrointestinal nematode infections with resistance against macrocyclic lactones was estimated to be € 38 million [€ 11–87 million] annually. The annual estimated costs of helminth infections per sector were € 941 million [€ 488 – 1442 million] in dairy cattle, € 423 million [€ 205–663 million] in beef cattle, € 151million [€ 90–213 million] in dairy sheep, € 206 million [€ 132–248 million] in meat sheep and € 86 million [€ 67–107 million] in dairy goats. Important data gaps were present in all phases of the calculations which lead to large uncertainties around the estimates. Accessibility of more granular animal population datasets at EU level, deeper knowledge of the effects of infection on production, levels of infection and livestock grazing exposure across Europe would make the largest contribution to improved burden assessments. The known current public investment in research on helminth control was 0.15 % of the estimated annual costs for the considered parasitic diseases. Our data suggest that the costs of enzootic helminth infections which usually occur at high prevalence annually in ruminants, are similar or higher than reported costs of epizootic diseases. Our data can support decision making in research and policy to mitigate the negative impacts of helminth infections and anthelmintic resistance in Europe, and provide a baseline against which to measure future changes., This article is based upon work from COST Action COMBAR CA16230, supported by COST (European Cooperation in Science and Technology) and from the Livestock helminth Research Alliance (LiHRA). HRV and ERM are supported by the BBSRC BUG (Building on the Genome) sLoLa project (grant ref: BB/M003949/1, and BB/ R010250/1). HRV is also supported by the University of Liverpool’s Institute of Infection and Global Health. MMV was funded by the Spanish “Ramón y Cajal” Programme, Ministry of Economy and Competitiveness (Ministerio de Economía y Competitividad; RYC-2015-18368).
Published: 2020
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45. Characteristics, Main Impacts, and Stewardship of Natural and Artificial Freshwater Environments: Consequences for Biodiversity Conservation

Author: Rossano Bolpagni, Martina Čtvrtlíková, Alex Borrini, Stefano Segadelli, Marco Cantonati, Zlatko Levkov, Núria Cid, Lawrence E. Stevens, Jani Heino, Diana M. P. Galassi, Petr Znachor, Eren Turak, Michal Hájek, Catherine M. Pringle, Abdullah A. Saber, John S. Richardson, Paul B. Hamilton, Barbara Fiasca, Sandra Poikane, Mattia Di Cicco, Jan Kubečka, Ian Hawes, Luigi Naselli-Flores, Museo delle Scienze, Drexel University, JRC Institute for the Protection and Security of the Citizen [Ispra] (IPSC), European Commission - Joint Research Centre [Ispra] (JRC), Department of Infectious Diseases [Athens, GA, USA] (Odum School of Ecology), University of Georgia [USA]-College of Veterinary Medicine [Athens, GA, USA], Museum Northern Arizona Springs Stewardship Inst, ‎ NSW Dept Planning Ind & Environm, School of Biological, Earth and Environmental Sciences [Sydney] (BEES), University of New South Wales [Sydney] (UNSW), Finnish Environment Institute (SYKE), University of British Columbia (UBC), University of Parma = Università degli studi di Parma [Parme, Italie], Riverly (Riverly), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Czech Academy of Sciences [Prague] (CAS), University of L'Aquila [Italy] (UNIVAQ), Masaryk University [Brno] (MUNI), University of Waikato [Hamilton], Ss. Cyril and Methodius University in Skopje, Université de Palerme (Univ. Palerme), Université de palerme, Université Ain Shams, Canadian Museum of Nature (CANADA), Servizio Osservatorio Suoli e Bonifiche (ARPAV), ARPAV, AQUALIFE LIFE12 BIO/IT/000231, ERDF/ESF project CZ.02.1.01/0.0/0.0/16_025/0007417, GX19-28491X, Cantonati M., Poikane S., Pringle C.M., Stevens L.E., Turak E., Heino J., Richardson J.S., Bolpagni R., Borrini A., Cid N., Ctvrtlikova M., Galassi D.M.P., Hajek M., Hawes I., Levkov Z., Naselli Flores L., Saber A.A., Di Cicco M., Fiasca B., Hamilton P.B., Kubecka J., Segadelli S., and Znachor P.
Subjects: 0106 biological sciences, lcsh:Hydraulic engineering, vaikutukset, Geography, Planning and Development, Biodiversity, habitat, Wetland, habitaatti, 01 natural sciences, Biochemistry, Freshwater ecosystem, Least-impaired habitat relict, ekosysteemit, lcsh:Water supply for domestic and industrial purposes, elinympäristö, freshwater, Water Science and Technology, biodiversity, geography.geographical_feature_category, Ecology, conservation, 6. Clean water, foundation species, Overexploitation, Habitat, [SDE]Environmental Sciences, impact, luonnonsuojelu, Settore BIO/07 - Ecologia, Conservation, Ecosystem, Foundation species, Freshwater, Impact, Least-impaired habitat relicts, Stewardship, Aquatic Science, 010603 evolutionary biology, hoito, stewardship, lcsh:TC1-978, 14. Life underwater, ecosystem, geography, lcsh:TD201-500, Foundation specie, 010604 marine biology & hydrobiology, least-impaired habitat relicts, 15. Life on land, luonnon monimuotoisuus, biodiversiteetti, Habitat destruction, 13. Climate action, Threatened species, Settore BIO/03 - Botanica Ambientale E Applicata, Environmental science, makea vesi
Abstract: International audience; In this overview (introductory article to a special issue including 14 papers), we consider all main types of natural and artificial inland freshwater habitas (fwh). For each type, we identify the main biodiversity patterns and ecological features, human impacts on the system and environmental issues, and discuss ways to use this information to improve stewardship. Examples of selected key biodiversity/ecological features (habitat type): narrow endemics, sensitive (groundwater and GDEs); crenobionts, LIHRes (springs); unidirectional flow, nutrient spiraling (streams); naturally turbid, floodplains, large-bodied species (large rivers); depth-variation in benthic communities (lakes); endemism and diversity (ancient lakes); threatened, sensitive species (oxbow lakes, SWE); diverse, reduced littoral (reservoirs); cold-adapted species (Boreal and Arctic fwh); endemism, depauperate (Antarctic fwh); flood pulse, intermittent wetlands, biggest river basins (tropical fwh); variable hydrologic regime—periods of drying, flash floods (arid-climate fwh). Selected impacts: eutrophication and other pollution, hydrologic modifications, overexploitation, habitat destruction, invasive species, salinization. Climate change is a threat multiplier, and it is important to quantify resistance, resilience, and recovery to assess the strategic role of the different types of freshwater ecosystems and their value for biodiversity conservation. Effective conservation solutions are dependent on an understanding of connectivity between different freshwater ecosystems (including related terrestrial, coastal and marine systems).
Published: 2020
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46. The westernmost Late Miocene-Pliocene volcanic activity in the Vardar Zone (North Macedonia) Geochronology, petrology and geochemistry of Pakoševo, Debrište and Šumovit Greben volcanic centers

Author: Molnár, Kata, Dibacto, Stéphane, Lahitte, Pierre, Temovski, Marjan, Agostini, Samuele, Benkó, Zsolt, Ionescu, Artur, Milevski, Ivica, Palcsu, László, Isotope Climatology and Environmental Research Centre, Institute for Nuclear Research, Géosciences Paris Saclay (GEOPS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CNR Istituto di Geoscienze e Georisorse [Pisa] (IGG-CNR), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Department of Physics and Geology [Perugia], Università degli Studi di Perugia = University of Perugia (UNIPG), and Ss. Cyril and Methodius University in Skopje (UKIM)
Subjects: [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020
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47. International external quality assurance of JAK2 V617F quantification

Author: Julia Asp, Marta Vorland, Anni Aggerholm, Lasse Kjær, Karl Haslam, Elisabeth Oppliger Leibundgut, Rajko Kusec, Karolina Matiakowska, Robert Kralovics, Frank Dicker, Alessandro Pancrazzi, Morten Andersen, Lars Palmqvist, Sylvie Hermouet, Margarida Coucelo, Bruno Cassinat, Filippo Navaglia, Andrey Sudarikov, Aleksandar Eftimov, Vibe Skov, Thomas Kielsgaard Kristensen, François Girodon, Laurence Lodé, Niels Pallisgaard, Eric Lippert, Jiri Schwarz, Marzena Wojtaszewska, Hajnalka Andrikovics, Guy Wayne Novotny, Dorota Link-Lenczowska, Susanna Akiki, Melanie J. Percy, Dina Naguib, Beatriz Bellosillo, Department of Clinical Chemistry and Transfusion Medicine [Gothenburg, Sweden] (Institute of Biomedicine), University of Gothenburg (GU)-Sahlgrenska Academy at University of Gothenburg [Göteborg], Department of Hematology [Roskilde, Denmark], Zealand University Hospital [Roskilde, Denmark], Department of Pathology [Barcelona, Spain], Hospital del Mar [Barcelona, Spain], Department of Pathology [Odense, Denmark], Odense University Hospital [Odense, Denmark], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Munich Leukemia Laboratory [Munich, Germany], Institute of Hematology and Blood Transfusion [Prague, Czech Republic], Department of Hematology and Bone Marrow Transplantation [Poznan, Poland], Poznan University of Medical Sciences [Poznan, Poland], Department of Laboratory Medicine and Pathology [Doha, Qatar], Qatar Rehabilitation Institute (QRI)-Hamad Bin Khalifa Medical City (HBKM), Aarhus University Hospital, Rigshospitalet [Copenhagen], Copenhagen University Hospital, Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), University of Bern [Bern, Switzerland] (University Hospital Bern ), Centro di Ricerca e Innovazione per le Malattie Mieloproliferative - CRIMM [ Florence, Italy], Haukeland University Hospital, University of Bergen (UiB), Central Hospital of Southern Pest [Budapest, Hungary], CeMM Research Center for Molecular Medicine [Vienna, Austria], Austrian Academy of Sciences (OeAW), Department of Internal Medicine I [Vienna, Austria], Medizinische Universität Wien = Medical University of Vienna, Service de Biologie Cellulaire [AP-HP, Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Clinical Hematology Unit, Hospital Pediátrico [Coimbra, Portugal], Centro Hospitalar e Universitário [Coimbra], Center for Biomolecular Pharmaceutical Analyses [Skopje, Republic of Macedonia] (Faculty of Pharmacy), University of Ss. Cyril and Methodius in Skopje, Macedonia (UKIM), St James’s Hospital [Dublin, Ireland], Zagreb School of Medicine [Zagreb, Croatia] (Dubrava University Hospital), University of Zagreb, Molecular Diagnostics Laboratory [Krakow, Poland] (Hematology Diagnostics Department), Jagiellonian University Hospital [Krakow, Poland], Hématologie Biologique [CHU de Montpellier], Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Faculty of Medicine [Bydgoszcz, Poland], Nicolaus Copernicus University [Toruń], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Department of Laboratory Medicine [Padova, Italy], University - Hospital of Padova [Italy], Department of Hematology & Department of Pathology [Herlev, Denmark] (Molecular Unit), Herlev and Gentofte Hospital-University of Copenhagen = Københavns Universitet (KU), Belfast City Hospital [Belfast, UK], National Research Center for Hematology [Moscow, Russia], Molecular Mechanisms of Chronic Inflammation in Hematological Diseases (CRCINA-ÉQUIPE 16), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Laboratoire d'Hematologie [CHU Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), RK acknowledges the support received by the Austrian Science Fund (FWF): F4702-B20 and P29018-B30., Bernardo, Elizabeth, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Service de Biologie Cellulaire [Saint-Louis], Ss. Cyril and Methodius University in Skopje (UKIM), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP), Herlev and Gentofte Hospital-University of Copenhagen = Københavns Universitet (UCPH), and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)
Subjects: Male, medicine.medical_specialty, Standardization, Quality Assurance, Health Care, Computer science, media_common.quotation_subject, Mutation, Missense, [SDV.CAN]Life Sciences [q-bio]/Cancer, 610 Medicine & health, Real-Time Polymerase Chain Reaction, Real-Time Polymerase Chain Reaction/standards, Myeloproliferative neoplasms, 03 medical and health sciences, External quality assurance, JAK2 V617F, Quantitative PCR, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, hemic and lymphatic diseases, medicine, Humans, Medical physics, Quality (business), Instrumentation (computer programming), Pathology, Molecular, media_common, Janus Kinase 2/genetics, business.industry, Amino acid substitution, Hematology, General Medicine, Janus Kinase 2, Amino Acid Substitution, Pathology, Molecular/standards, 030220 oncology & carcinogenesis, Female, business, Quality assurance, 030215 immunology
Abstract: IF 2.845; International audience; External quality assurance (EQA) programs are vital to ensure high quality and standardized results in molecular diagnostics. It is important that EQA for quantitative analysis takes into account the variation in methodology. Results cannot be expected to be more accurate than limits of the technology used, and it is essential to recognize factors causing substantial outlier results. The present study aimed to identify parameters of specific importance for JAK2 V617F quantification by quantitative PCR, using different starting materials, assays, and technical platforms. Sixteen samples were issued to participating laboratories in two EQA rounds. In the first round, 19 laboratories from 11 European countries analyzing JAK2 V617F as part of their routine diagnostics returned results from in-house assays. In the second round, 25 laboratories from 17 countries participated. Despite variations in starting material, assay setup and instrumentation the laboratories were generally well aligned in the EQA program. However, EQA based on a single technology appears to be a valuable tool to achieve standardization of the quantification of JAK2 V617F allelic burden.
Published: 2019
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48. First international collaborative study to evaluate rabies antibody detection method for use in monitoring the effectiveness of oral vaccination programmes in fox and raccoon dog in Europe

Author: Ingrida Jaceviciene, D Boncea, K. Mahar, S Moore, Peter Hostnik, T Nokireki, S. Mrenoski, P Giraud, E Wodak, Miroslav Mojzis, D David, Ernest Ngoepe, Marcin Smreczak, Bertel Strandbygaard, Florence Cliquet, S Kenklies, M Nishimura, L B Chaves, Thomas Müller, Tomislav Bedeković, A Baur, P De Benedictis, I Almeida, M. Dobrostana, Marine Wasniewski, N Pejovic, Matthias König, Laboratoire de la rage et de la faune sauvage de Nancy (LRFSN), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Laboratorio Nacional de Investigacao Veterinaria (LNIV), Vet Med Labor GmbH, Croatian Veterinary Institute Laboratory for Rabies/Virology, Institute for Diagnosis and Animal Health, Laboratório de Diagnóstico da Raiva, Instituto Pasteur, Kimron Veterinary Institute Rabies Laboratory, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Institute of Food Safety, Animal Health and Environment (BIOR), Laboratoire Départemental d'Analyses du Pas-de-Calais, National Veterinary Institute [Uppsala] (SVA), National Food and Veterinary Risk Assessment Institute of Lithuania, Landesamt für Verbraucherschutz Sachsen-Anhalt, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Gießen (JLU), Estonian Veterinary and Food Laboratory, State Veterinary Institute Zvolen, Kansas State University, Ss. Cyril and Methodius University in Skopje, Friedrich-Loeffler-Institut (FLI), Agricultural Research Council-Onderstepoort Veterinary Institute, Research Institute for Animal Science In Biochemistry and Toxicology, Finnish Food safety Authority, Diagnostic Veterinary Laboratory Montenegro, National Veterinary Research Institute [Pulawy, Pologne] (NVRI), Danmarks Tekniske Universitet (DTU), and Institute for Veterinary Disease Control Mödling (AGES)
Subjects: 0301 basic medicine, Veterinary medicine, Oral vaccination campaigns, Rabies, International Cooperation, [SDV]Life Sciences [q-bio], Concordance, 030106 microbiology, Administration, Oral, Foxes, Animals, Wild, Enzyme-Linked Immunosorbent Assay, Antibodies, Viral, Sensitivity and Specificity, Rabies vaccination, Serology, 03 medical and health sciences, Virology, parasitic diseases, medicine, Animals, Collaborative study, Disease surveillance, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Immunization Programs, business.industry, Reproducibility of Results, Raccoon Dogs, medicine.disease, 3. Good health, Vaccination, 030104 developmental biology, Rabies Vaccines, Rabies virus, Rabies antibodies, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, ELISA, Reagent Kits, Diagnostic, business, Antibody detection
Abstract: International audience; The most effective and sustainable method to control and eliminate rabies in wildlife is the oral rabies vaccination (ORV) of target species, namely foxes and raccoon dogs in Europe. According to WHO and OIE, the effectiveness of oral vaccination campaigns should be regularly assessed via disease surveillance and ORV antibody monitoring. Rabies antibodies are generally screened for in field animal cadavers, whose body fluids are often of poor quality. Therefore, the use of alternative methods such as the enzyme-linked immunosorbent assay (ELISA) has been proposed to improve reliability of serological results obtained on wildlife samples. We undertook an international collaborative study to determine if the commercial BioPro ELISA Rabies Ab kit is a reliable and reproducible tool for rabies serological testing. Our results reveal that the overall specificity evaluated on naive samples reached 96.7%, and the coefficients of concordance obtained for fox and raccoon dog samples were 97.2% and 97.5%, respectively. The overall agreement values obtained for the four marketed oral vaccines used in Europe were all equal to or greater than 95%. The coefficients of concordance obtained by laboratories ranged from 87.2% to 100%. The results of this collaborative study show good robustness and reproducibility of the BioPro ELISA Rabies Ab kit.
Published: 2016
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49. Education Component in Creation of Entrepreneurship Society

Author: Maria Zarezankova-Potevska and University of Skopje, Faculty of Social Sciences (FON)
Subjects: Entrepreneurship, Economic growth, entrepreneurial spirit, media_common.quotation_subject, przedsiębiorczość, Standard of living, Informal education, entrepreneurship, entrepreneurial culture, lcsh:Education (General), Political science, kultura przedsiębiorczości, media_common.cataloged_instance, European union, duch przedsiębiorczości, Human resources, Curriculum, Social progress, media_common, education, business.industry, Life Long Learning (LLL), edukacja, uczenie się przez całe życie, Prosperity, business, lcsh:L7-991
Abstract: Entrepreneurship as a style and way of thinking and working has century’s long history in the human society. Thanks to creative and open-minded people in the past and today, the human societies ensured rapid growth and improved the living standards. Innovative ideas triggered higher level of economic development in the world through new technologies, which has led to improving the quality of life. Unfortunately, not all countries in the world enjoy the same social progress, due to many problems in the areas of economic and political domain, access to natural and human resources, demographic issues, low level of education, etc. The history of economics has shown that in the countries with open market economy, the entrepreneurial spirit is developed on the higher level. The entrepreneurial culture provides many opportunities for implementation of more innovative business ideas, new technical solutions, advanced technologies, new working methods and continued life-long education aimed to improve the life of the society. Creative people and their ideas are crucial for the development and cultivation of the entrepreneurial spirit and culture in every country, which is closely connected to the education level gained through the formal and informal education systems, which depend of the country’s economic development. A good education system plays an important role in creating good economic policies in each country, has influence on the economic development, business performance and the progress of the whole human society. Innovation is a unique path to prosperity and well-being. Therefore, the economic scientists recognize entrepreneurship as a dynamic factor of production, in addition to labor, capital and land. The European Union (EU) recognizes and promotes many strategies and polices that focus on teaching entrepreneurship from early ages, starting within primary and secondary education, and continuing at the university levels. Developing new education curriculum in formal and informal education systems is a priority in the government’s policies of the developed countries. The curriculum might include compulsory courses in entrepreneurship, continuous learning, and tailored courses with specific task to teach people how to be creative and innovative, regardless of their cultural differences and traditions. Universities should play an important role in educating young people how to do business to work and succeed in the global market economy. The universities in many developed countries such as the USA, Japan, and Germany, have opened business centers, supported technological incubators and parks, and established specialized agencies that provide help and support to entrepreneurs. All these activities contribute to the development of the entrepreneurial society, where creative people can easily find their place for business and life. Thus, education is one of the key factors of economic development. The knowledge-based economy is a modern economy that makes the goal of many countries of today’s world. The less developed states should strive towards the modern trends in the education processes as well as business and entrepreneurial behavior, which is the critical factor in the development of economic and social welfare. They should make more efforts to support the business environment through progressive and modern education systems that would facilitate the development of entrepreneurial spirit and culture. Additionally, they should follow the new trends in the global economy that lead to social cohesion and better economic prosperity. Przedsiębiorczość jako styl oraz sposób myślenia i pracy jest obecna w naszym społeczeństwie od stu lat. Dzięki kreatywnym ludziom o otwartych umysłach, żyjącym w przeszłości i obecnie nastąpił szybki rozwój i poprawa warunków ludzkiego życia. Innowacyjne pomysły wprowadziły świat na wyższy poziom rozwoju gospodarczego za pomocą nowych technologii, które przynoszą poprawę jakości życia. Niestety, nie wszystkie kraje na świecie cieszą się takim samym poziomem postępu społecznego z powodu licznych problemów występujących w obszarach gospodarczych i politycznych, obejmujących między innymi dostęp do zasobów naturalnych i ludzkich, problemy demograficzne, niski poziom wykształcenia itp. Historia ekonomii pokazuje, że w krajach o otwartej gospodarce rynkowej duch przedsiębiorczości jest rozwijany na wyższym poziomie. Kultura przedsiębiorczości daje wiele możliwości wdrażania bardziej innowacyjnych pomysłów biznesowych, nowych rozwiązań technicznych, zaawansowanych technologii, nowych metod pracy oraz edukacji przez całe życie, których celem jest poprawa życia społeczeństwa. Kreatywni ludzie i ich pomysły to elementy kluczowe dla rozwoju i kultywowania ducha oraz kultury przedsiębiorczości w każdym kraju, co ma ścisły związek z poziomem wykształcenia zdobytego za pośrednictwem formalnych i nieformalnych systemów edukacji, które są uzależnione od rozwoju gospodarczego kraju. Dobry system edukacji odgrywa ważną rolę w tworzeniu dobrej polityki gospodarczej w poszczególnych krajach, ma wpływ na rozwój gospodarczy i wydajność przedsiębiorstw, a także na postęp całego społeczeństwa. Innowacja to unikalna droga do dobrobytu. Dlatego też badacze zajmujący się ekonomią uznają przedsiębiorczość za kolejny dynamiczny czynnik produkcji, oprócz pracy, kapitału i ziemi. Unia Europejska (UE) uznaje i wspiera wiele strategii i polityk, które skupiają się na nauczaniu przedsiębiorczości od wczesnego wieku, począwszy od szkół podstawowych i średnich, a kontynuując na poziomie szkolnictwa wyższego. Opracowywanie nowych programów kształcenia w formalnych i nieformalnych systemach edukacji to priorytet polityki rządowej w krajach rozwiniętych. Takie programy mogą obejmować przedmioty obowiązkowe z zakresu przedsiębiorczości, formy kształcenia ustawicznego, specjalnie przygotowane kursy uczące ludzi kreatywności i innowacyjności, niezależnie od dzielących ich różnic kulturowych i tradycji. Uniwersytety powinny odgrywać istotną rolę w kształceniu młodych ludzi w zakresie prowadzenia firm oraz przygotowywać ich do funkcjonowania i odnoszenia sukcesów w globalnej gospodarce rynkowej. Uczelnie w wielu krajach rozwiniętych, takich jak USA, Japonia i Niemcy, otwierają centra biznesowe, wspierają inkubatory i parki technologiczne i zakładają specjalistyczne agencje zapewniające pomoc i wsparcie dla przedsiębiorców. Wszystkie te działania przyczyniają się do rozwoju społeczeństwa przedsiębiorczego, w którym kreatywni ludzie mogą bez trudu znaleźć swoje miejsce do życia i prowadzenia biznesu. Edukacja jest jednym z kluczowych czynników rozwoju gospodarczego. Gospodarka oparta na wiedzy to nowoczesna gospodarka, która jest celem wielu państw dzisiejszego świata. Kraje słabiej rozwinięte powinny dążyć do wdrażania współczesnych trendów w procesach edukacyjnych oraz zachowaniach biznesowych, ponieważ jest to kluczowy czynnik rozwoju gospodarczego i społecznego dobrostanu. Powinny również wspierać środowisko biznesowe poprzez stopniowe wdrażanie nowoczesnego systemu edukacji, który będzie zgodny z duchem i kulturą przedsiębiorczości. Jednocześnie, powinny postępować zgodnie z nowymi trendami w gospodarce światowej, które prowadzą do spójności społecznej i lepszej koniunktury gospodarczej.
Published: 2016

50. PySFC - A System for Prosody Analysis based on the Superposition of Functional Contours Prosody Model

Author: Gérard Bailly, Branislav Gerazov, GIPSA - Cognitive Robotics, Interactive Systems, & Speech Processing (GIPSA-CRISSP), Département Parole et Cognition (GIPSA-DPC), Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Grenoble Images Parole Signal Automatique (GIPSA-lab ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of Ss. Cyril and Methodius in Skopje, Macedonia (UKIM), H2020 745802 Prosodeep, European Project: 745802,Prosodeep, and Ss. Cyril and Methodius University in Skopje (UKIM)
Subjects: Facial expression, model, LOOP (programming language), Computer science, business.industry, Speech recognition, free software, Intonation (linguistics), duration, ENCODE, intonation, Superposition principle, ComputingMethodologies_PATTERNRECOGNITION, Software, prosody, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Prosody, Set (psychology), business
Abstract: International audience; The Superposition of Functional Contours (SFC) prosody model decomposes the intonation and duration contours into elementary contours that encode specific linguistic functions. It is based on training a set of contour generators trained in an analysis-by-synthesis loop. The model has been proven to be able to extract these functional contours for multiple linguistic tasks and for multiple languages. It has also been successfully used to decompose and then synthesise visual prosody in terms of facial expression. PySFC is a fully functional prosody analysis system built around the SFC that is completely free software. It is created to ease access to the SFC model for the speech research community, and to facilitate further development of de-compositional prosody models.
Published: 2018
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