Search

Your search keyword '"Unson-O'Brien, Cecilia"' showing total 4 results
Start Over Author "Unson-O'Brien, Cecilia"
4 results on '"Unson-O'Brien, Cecilia"'

1. Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial

Author

Gruell, Henning, Gunst, Jesper D, Cohen, Yehuda Z, Pahus, Marie H, Malin, Jakob J, Platten, Martin, Millard, Katrina G, Tolstrup, Martin, Jones, R Brad, Conce Alberto, Winnifer D, Lorenzi, Julio C C, Oliveira, Thiago Y, Kümmerle, Tim, Suárez, Isabelle, Unson-O'Brien, Cecilia, Nogueira, Lilian, Olesen, Rikke, Østergaard, Lars, Nielsen, Henrik, Lehmann, Clara, Nussenzweig, Michel C, Fätkenheuer, Gerd, Klein, Florian, Caskey, Marina, and Søgaard, Ole S

Published
2022
Full Text
View/download PDF

2. Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Author

Mendoza, Pilar, Gruell, Henning, Nogueira, Lilian, Pai, Joy A., Butler, Allison L., Millard, Katrina, Lehmann, Clara, Suárez, Isabelle, Oliveira, Thiago Y., Lorenzi, Julio C. C., Cohen, Yehuda Z., Wyen, Christoph, Kümmerle, Tim, Karagounis, Theodora, Lu, Ching-Lan, Handl, Lisa, Unson-O’Brien, Cecilia, Patel, Roshni, Ruping, Carola, Schlotz, Maike, Witmer-Pack, Maggi, Shimeliovich, Irina, Kremer, Gisela, Thomas, Eleonore, Seaton, Kelly E., Horowitz, Jill, West, Jr, Anthony P., Bjorkman, Pamela J., Tomaras, Georgia D., Gulick, Roy M., Pfeifer, Nico, Fätkenheuer, Gerd, Seaman, Michael S., Klein, Florian, Caskey, Marina, and Nussenzweig, Michel C.

Published
2018
Full Text
View/download PDF

3. Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Author

Caskey, Marina, Schoofs, Till, Gruell, Henning, Settler, Allison, Karagounis, Theodora, Kreider, Edward F, Murrell, Ben, Pfeifer, Nico, Nogueira, Lilian, Oliveira, Thiago Y, Learn, Gerald H, Cohen, Yehuda Z, Lehmann, Clara, Gillor, Daniel, Shimeliovich, Irina, Unson-O'Brien, Cecilia, Weiland, Daniela, Robles, Alexander, Kümmerle, Tim, Wyen, Christoph, Levin, Rebeka, Witmer-Pack, Maggi, Eren, Kemal, Ignacio, Caroline, Kiss, Szilard, West, Anthony P, Jr, Mouquet, Hugo, Zingman, Barry S, Gulick, Roy M, Keler, Tibor, Bjorkman, Pamela J, Seaman, Michael S, Hahn, Beatrice H, Fätkenheuer, Gerd, Schlesinger, Sarah J, Nussenzweig, Michel C, and Klein, Florian

Subjects
HIV infections -- Genetic aspects -- Development and progression -- Care and treatment, Viral proteins -- Health aspects, Monoclonal antibodies -- Patient outcomes, Biological sciences, Health
Abstract

Monoclonal antibody 10-1074 targets the V3 glycan supersite on the HIV-1 envelope (Env) protein. It is among the most potent anti-HIV-1 neutralizing antibodies isolated so far. Here we report on its safety and activity in 33 individuals who received a single intravenous infusion of the antibody. 10-1074 was well tolerated and had a half-life of 24.0 d in participants without HIV-1 infection and 12.8 d in individuals with HIV-1 infection. Thirteen individuals with viremia received the highest dose of 30 mg/kg 10-1074. Eleven of these participants were 10-1074-sensitive and showed a rapid decline in viremia by a mean of 1.52 log[sub.10] copies/ml. Virologic analysis revealed the emergence of multiple independent 10-1074-resistant viruses in the first weeks after infusion. Emerging escape variants were generally resistant to the related V3-specific antibody PGT121, but remained sensitive to antibodies targeting nonoverlapping epitopes, such as the anti-CD4-binding-site antibodies 3BNC117 and VRC01. The results demonstrate the safety and activity of 10-1074 in humans and support the idea that antibodies targeting the V3 glycan supersite might be useful for the treatment and prevention of HIV-1 infection., Author(s): Marina Caskey (corresponding author) [1]; Till Schoofs [1]; Henning Gruell [2, 3, 4]; Allison Settler [1]; Theodora Karagounis [1]; Edward F Kreider [5]; Ben Murrell [6]; Nico Pfeifer [7]; [...]

Published
2017
Full Text
View/download PDF

4. Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study

Author

Cohen, Yehuda Z., primary, Butler, Allison L., additional, Millard, Katrina, additional, Witmer-Pack, Maggi, additional, Levin, Rebeka, additional, Unson-O’Brien, Cecilia, additional, Patel, Roshni, additional, Shimeliovich, Irina, additional, Lorenzi, Julio C. C., additional, Horowitz, Jill, additional, Walsh, Stephen R., additional, Lin, Shu, additional, Weiner, Joshua A., additional, Tse, Anna, additional, Sato, Alicia, additional, Bennett, Chelsey, additional, Mayer, Bryan, additional, Seaton, Kelly E., additional, Yates, Nicole L., additional, Baden, Lindsey R., additional, deCamp, Allan C., additional, Ackerman, Margaret E., additional, Seaman, Michael S., additional, Tomaras, Georgia D., additional, Nussenzweig, Michel C., additional, and Caskey, Marina, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results