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In this second part of our survey on experimental research in Synthetic Molecular Communication (SMC), we review works on long-range SMC systems, i.e., systems with communication ranges of more than a few millimeters. Despite the importance of experimental research for the evolution of SMC towards a mature communication paradigm that will eventually support revolutionary applications beyond the reach of today's prevalent communication paradigms, the existing body of literature is still comparatively sparse. Long-range SMC systems have been proposed in the literature for information transmission in two types of fluid media, liquid and air. While both types of SMC systems, liquid-based and air-based systems, rely on encoding and transmitting information using molecules, they differ substantially in terms of the physical system designs and in the type of applications they are intended for. In this paper, we present a systematic characterization of experimental works on long-range SMC that reveals the major drivers of these works in terms of the respective target applications. Furthermore, the physical designs for long-range SMC proposed in the literature are comprehensively reviewed. In this way, our survey will contribute to making experimental research in this field more accessible and identifying novel directions for future research., Comment: 10 pages, 2 tables, 4 figures. Accepted for publication in the IEEE Nanotechnology Magazine

Since its emergence from the communication engineering community around one and a half decades ago, the field of Synthetic Molecular Communication (SMC) has experienced continued growth, both in the number of technical contributions from a vibrant community and in terms of research funding. Throughout this process, the vision of SMC as a novel, revolutionary communication paradigm has constantly evolved, driven by feedback from theoretical and experimental studies, respectively. It is believed that especially the latter ones will be crucial for the transition of SMC towards a higher technology readiness level in the near future. In this spirit, we present here a comprehensive survey of experimental research in SMC. In particular, this survey focuses on highlighting the major drivers behind different lines of experimental research in terms of the respective envisioned applications. This approach allows us to categorize existing works and identify current research gaps that still hinder the development of practical SMC-based applications. Our survey consists of two parts; this paper and a companion paper. While the companion paper focuses on SMC with relatively long communication ranges, this paper covers SMC over short distances of typically not more than a few millimeters., Comment: 10 pages, 1 table, 5 figures. Accepted for publication in the IEEE Nanotechnology Magazine

In the emerging field of molecular communication (MC), testbeds are needed to validate theoretical concepts, motivate applications, and guide further modeling efforts. To this end, this paper presents a flexible and extendable in-vessel testbed for flow-based macroscopic MC, abstractly modeling, e.g., a part of a chemical reactor or a blood vessel. Signaling is based on injecting non-reactive superparamagnetic iron oxide nanoparticles (SPIONs) dispersed in an aqueous suspension into a tube with background flow. A commercial magnetic susceptometer is used for non-intrusive downstream signal reception. To shed light on the operation of the testbed, we identify the physical mechanisms governing the transmission, propagation, and reception of the information-carrying SPIONs. Moreover, to facilitate system design, we propose a closed-form parametric expression for the end-to-end channel impulse response (CIR). The proposed CIR model is shown to consistently capture the experimentally observed distance-dependent impulse response peak heights and peak decays for transmission distances from 5cm to 40cm. Moreover, to validate our testbed, reliable communication is demonstrated based on experimental data for model-agnostic and model-based detection methods., Comment: \c{opyright} 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works

Superparamagnetic iron oxide nanoparticles (SPIONs) have recently been introduced as information carriers in a testbed for molecular communication (MC) in duct flow. Here, a new receiver for this testbed is presented, based on the concept of a bridge circuit. The capability for a reliable transmission using the testbed and detection of the proposed receiver was evaluated by sending a text message and a 80 bit random sequence at a bit rate of 1/s, which resulted in a bit error rate of 0 %. Furthermore, the sensitivity of the device was assessed by a dilution series, which gave a limit for the detectability of peaks between 0.1 to 0.5 mg/mL. Compared to the commercial susceptometer that was previously used as receiver, the new detector provides an increased sampling rate of 100 samples/s and flexibility in the dimensions of the propagation channel. Furthermore, it allows to implement both single-ended and differential signaling in SPION-bases MC testbeds., Comment: ACM NanoCom 2019

The possibility to guide and control magnetic nanoparticles in a non-invasive manner has spawned various applications in biotechnology such as targeted drug delivery and sensing of biological substances. These applications are facilitated by the engineering of the size, selective chemical reactivity, and general chemical composition of the employed particles. Motivated by their widespread use and favorable properties, in this paper, we provide a theoretical study of the potential benefits of magnetic nanoparticles for the design of molecular communication systems. In particular, we consider magnetic nanoparticle based communication in a microfluidic channel where an external magnetic field is employed to attract the information-carrying particles to the receiver. We show that the particle transport affected by Brownian motion, fluid flow, and an external magnetic field can be mathematically modeled as diffusion with drift. Thereby, we reveal that the key parameters determining the magnetic force are the particle size and the magnetic field gradient. Moreover, we derive an analytical expression for the channel impulse response, which is used to evaluate the potential gain in the expected number of observed nanoparticles due to the magnetic field. Furthermore, adopting the symbol error rate as performance metric, we show that using magnetic nanoparticles can enable reliable communication in the presence of disruptive fluid flow. Numerical results obtained by particle-based simulation validate the accuracy of the derived analytical expressions., Comment: 15 pages (double column), 8 figures, 1 table. Accepted for publication in the IEEE Transactions on NanoBioscience (TNB). (Author's comment: This is the extended journal version of the conference paper arXiv:1704.04206)

Simple and easy to implement testbeds are needed to further advance molecular communication research. To this end, this paper presents an in-vessel molecular communication testbed using magnetic nanoparticles dispersed in an aqueous suspension as they are also used for drug targeting in biotechnology. The transmitter is realized by an electronic pump for injection via a Y-connector. A second pump provides a background flow for signal propagation. For signal reception, we employ a susceptometer, an electronic device including a coil, where the magnetic particles move through and generate an electrical signal. We present experimental results for the transmission of a binary sequence and the system response following a single injection. For this flow-driven particle transport, we propose a simple parameterized mathematical model for evaluating the system response., Comment: 6 pages, 4 figures, 1 table, invited paper in IEEE International Workshop on Signal Processing Advances in Wireless Communications (SPAWC) 2018

In this paper, we propose to use magnetic nanoparticles as information carriers for molecular communication. This enables the use of an external magnetic field to guide information-carrying particles towards the receiver. We show that the particle movement can be mathematically modeled as diffusion with drift. Thereby, we reveal that the key parameters determining the magnetic force are particle size and magnetic field gradient. As an example, we consider magnetic nanoparticle based communication in a bounded two-dimensional environment. For this model, we derive an analytical expression for the channel impulse response subject to fluid flow and magnetic drift. Furthermore, adopting the symbol error rate as performance metric, we show that using magnetic nanoparticles facilitates reliable communication, even in the presence of fluid flow., Comment: 6 pages, 4 figures, 1 table. Submitted to the IEEE Wireless Communications and Networking Conference (IEEE WCNC) 2018. Changes: Clarified two-dimensional environment