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18 results on '"Upadhyay, Navneet Kumar"'

14. Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential

Author

Bhardwaj, Kanchan, primary, Silva, Ana Sanches, additional, Atanassova, Maria, additional, Sharma, Rohit, additional, Nepovimova, Eugenie, additional, Musilek, Kamil, additional, Sharma, Ruchi, additional, Alghuthaymi, Mousa A., additional, Dhanjal, Daljeet Singh, additional, Nicoletti, Marcello, additional, Sharma, Bechan, additional, Upadhyay, Navneet Kumar, additional, Cruz-Martins, Natália, additional, Bhardwaj, Prerna, additional, and Kuča, Kamil, additional

Published
2021
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16. Understanding of Colistin Usage in Food Animals and Available Detection Techniques: A Review

Author

Kumar, Harsh, primary, Chen, Bing-Huei, additional, Kuca, Kamil, additional, Nepovimova, Eugenie, additional, Kaushal, Ankur, additional, Nagraik, Rupak, additional, Bhatia, Shashi Kant, additional, Dhanjal, Daljeet Singh, additional, Kumar, Vinod, additional, Kumar, Anil, additional, Upadhyay, Navneet Kumar, additional, Verma, Rachna, additional, and Kumar, Dinesh, additional

Published
2020
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18. Long term delivery of glibenclamide from in situforming microparticles for the treatment of ischemic stroke

Author

Kaurav, Hemlata, Sharma, Ashish, Upadhyay, Navneet Kumar, and Kapoor, Deepak N.

Abstract

Glibenclamide, sulfonylurea receptor inhibitor, is reported to be neuroprotective in ischemic stroke by reducing cytotoxic edema, which is the primary cause of morbidity. As neurological worsening in stroke occurs from 3 to 10 days post-injury, there is a need to develop a system that would provide the release of glibenclamide for 10–15 days in a sustained manner in order to y improve the neurological functions effectively. In situforming microparticles (ISFM) of glibenclamide was developed using PLGA 50:50 as a biodegradable polymer and by applying RSM I-Optimal design. In vitroevaluation studies were carried out for optimized formulation. In vivopharmacological assessments and pharmacokinetics studies were performed in the Bilateral common carotid artery occlusion model (BCCAO) in Wistar rats. In vitrodrug release studies showed a minimum burst release at 12 h and maximum release on 15th day. In vivoresults showed a significant improvement in neurological functions, reduction in the infarct area, and hemispheric swelling in glibenclamide ISFM treated animals as compared to diseased animals. From in vitroand in vivoanimal studies, it was concluded that long-acting ISFM of glibenclamide was successfully developed, which showed drug release pattern in a sustained manner for up to 15 days for preventing the neurological worsening in stroke.

Published
2021
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