1. Using the PhenX Toolkit to Select Standard Measurement Protocols for Your Research Study
- Author
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Tabitha Hendershot, Erin M. Ramos, Catherine A. McCarty, Huaqin Helen Pan, Jonathan L. Haines, Mary L. Marazita, Carol Hamilton, Stephen Hwang, Michelle L Engle, and Lisa Ann Cox
- Subjects
Coronavirus disease 2019 (COVID-19) ,Electronic data capture ,Computer science ,Interdisciplinary Research ,Health Informatics ,Updated Protocol ,standard measures ,General Biochemistry, Genetics and Molecular Biology ,Domain (software engineering) ,genome‐wide association studies (GWAS) ,World Wide Web ,Documentation ,Humans ,Genetic Predisposition to Disease ,General Pharmacology, Toxicology and Pharmaceutics ,Protocol (science) ,Data collection ,General Immunology and Microbiology ,General Neuroscience ,phenotypes ,Human Genetics ,Environmental Exposure ,Environmental exposure ,Data dictionary ,data collection protocols ,Medical Laboratory Technology ,Phenotype ,Databases as Topic ,environmental exposures ,Software ,Genome-Wide Association Study - Abstract
The goals of PhenX (consensus measures for Phenotypes and eXposures) are to promote the use of standard measurement protocols and to help investigators identify opportunities for collaborative research and cross‐study analysis, thus increasing the impact of individual studies. The PhenX Toolkit (https://www.phenxtoolkit.org/) offers high‐quality, well‐established measurement protocols to assess phenotypes and exposures in studies with human participants. The Toolkit contains protocols representing 29 research domains and 6 specialty collections of protocols that add depth to the Toolkit in specific research areas (e.g., COVID‐19, Social Determinants of Health [SDoH], Blood Sciences Research [BSR], Mental Health Research [MHR], Tobacco Regulatory Research [TRR], and Substance Abuse and Addiction [SAA]). Protocols are recommended for inclusion in the PhenX Toolkit by Working Groups of domain experts using a consensus process that includes input from the scientific community. For each PhenX protocol, the Toolkit provides a detailed description, the rationale for inclusion, and supporting documentation. Users can browse protocols in the Toolkit, search the Toolkit using keywords, or use Browse Protocols Tree to identify protocols of interest. The PhenX Toolkit provides data dictionaries compatible with the database of Genotypes and Phenotypes (dbGaP), Research Electronic Data Capture (REDCap) data submission compatibility, and data collection worksheets to help investigators incorporate PhenX protocols into their study design. The PhenX Toolkit provides resources to help users identify published studies that used PhenX protocols. © 2021 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol: Using the PhenX Toolkit to support or extend study design
- Published
- 2021
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