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2. Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus

Author

Hashimoto, Masashi, Kuroda, Shinji, Kanaya, Nobuhiko, Kadowaki, Daisuke, Yoshida, Yusuke, Sakamoto, Masaki, Hamada, Yuki, Sugimoto, Ryoma, Yagi, Chiaki, Ohtani, Tomoko, Kumon, Kento, Kakiuchi, Yoshihiko, Yasui, Kazuya, Kikuchi, Satoru, Yoshida, Ryuichi, Tazawa, Hiroshi, Kagawa, Shunsuke, Yagi, Takahito, Urata, Yasuo, and Fujiwara, Toshiyoshi

Published
2024
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9. Telomerase-based circulating tumor cell detection for treatment response prediction in patients with non-small-cell lung cancer

Author

Sumiyoshi, Issei, primary, Togo, Shinsaku, additional, Okabe, Takahiro, additional, Abe, Kanae, additional, Watanabe, Junko, additional, Ochi, Yusuke, additional, Hoshi, Kazuaki, additional, Saiwaki, Shoko, additional, Nojiri, Shuko, additional, Fujimoto, Yuichi, additional, Namba, Yukiko, additional, Tabe, Yoko, additional, Urata, Yasuo, additional, and Takahashi, Kazuhisa, additional

Published
2024
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10. Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus

Author

Uotani, Koji, primary, Tazawa, Hiroshi, additional, Hasei, Joe, additional, Fujiwara, Tomohiro, additional, Yoshida, Aki, additional, Yamakawa, Yasuaki, additional, Omori, Toshinori, additional, Sugiu, Kazuhisa, additional, Komatsubara, Tadashi, additional, Kondo, Hiroya, additional, Morita, Takuya, additional, Kiyono, Masahiro, additional, Yokoo, Suguru, additional, Hata, Toshiaki, additional, Kunisada, Toshiyuki, additional, Takeda, Ken, additional, Urata, Yasuo, additional, Fujiwara, Toshiyoshi, additional, and Ozaki, Toshifumi, additional

Published
2024
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14. Tumor-targeting adenovirus OBP-401 inhibits primary and metastatic tumor growth of triple-negative breast cancer in orthotopic nude-mouse models

Author

Yano, Shuya, Takehara, Kiyoto, Kishimoto, Hiroyuki, Tazawa, Hiroshi, Urata, Yasuo, Kagawa, Shunsuke, Bouvet, Michael, Fujiwara, Toshiyoshi, and Hoffman, Robert M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Breast Cancer, 2.1 Biological and endogenous factors, Aetiology, Adenoviridae, Animals, Cell Line, Tumor, Disease Models, Animal, Female, Humans, Mammary Glands, Animal, Mice, Mice, Nude, Neoplasm Metastasis, Oncolytic Virotherapy, Organ Specificity, Telomerase, Triple Negative Breast Neoplasms, Xenograft Model Antitumor Assays, GFP, green fluorescent protein, RFP, red fluorescent protein, OBP-401, TNBC, adenovirus, high-metastatic, nude mouse, triple-negative breast cancer, variants, Oncology and carcinogenesis
Abstract

Our laboratory previously developed a highly-invasive, triple-negative breast cancer (TNBC) variant using serial orthotopic implantation of the human MDA-MB-231 cell line in nude mice. The isolated variant was highly-invasive in the mammary gland and lymphatic channels and metastasized to lymph nodes in 10 of 12 mice compared to 2 of 12 of the parental cell line. In the present study, the tumor-selective telomerase dependent OBP-401 adenovirus was injected intratumorally (i.t.) (1 × 108 PFU) when the high-metastatic MDA-MB-231 primary tumor expressing red fluorescent protein (MDA-MB-231-RFP) reached approximately 500 mm3 (diameter; 10 mm). The mock-infected orthotopic primary tumor grew rapidly. After i.t. OBP-401 injection, the growth of the orthotopic tumors was arrested. Six weeks after implantation, the fluorescent area and fluorescence intensity showed no increase from the beginning of treatment. OBP-401 was then injected into high-metastatic MDA-MB-231-RFP primary orthotopic tumor growing in mice which already had developed metastasis within lymphatic ducts. All 7 of 7 control mice subsequently developed lymph node metastasis. In contrast, none of 7 mice which received OBP-401 had lymph node metastasis. Seven of 7 control mice also had gross lung metastasis. In contrast, none of the 7 mice which received OBP-401 had gross lung metastasis. Confocal laser microscopy imaging demonstrated that all control mice had diffuse lung metastases. In contrast, all 7 mice which received OBP-401 only had a few metastatic cells in the lung. OBP-401 treatment significantly extended survival of the treated mice.

Published
2016

15. Fluorescence-guided surgery of a highly-metastatic variant of human triple-negative breast cancer targeted with a cancer-specific GFP adenovirus prevents recurrence

Author

Yano, Shuya, Takehara, Kiyoto, Miwa, Shinji, Kishimoto, Hiroyuki, Tazawa, Hiroshi, Urata, Yasuo, Kagawa, Shunsuke, Bouvet, Michael, Fujiwara, Toshiyoshi, and Hoffman, Robert M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Breast Cancer, Adenoviridae, Animals, Cell Line, Tumor, Cells, Cultured, Disease Models, Animal, Female, Gene Expression, Genetic Vectors, Green Fluorescent Proteins, Humans, Mice, Microscopy, Fluorescence, Optical Imaging, Recurrence, Surgery, Computer-Assisted, Transduction, Genetic, Triple Negative Breast Neoplasms, Xenograft Model Antitumor Assays, breast cancer, triple negative, nude mice, orthotopic, fluorescence-guided surgery, telomerase dependent, adenovirus, GFP/RFP, survival, Oncology and carcinogenesis
Abstract

We have previously developed a genetically-engineered GFP-expressing telomerase-dependent adenovirus, OBP-401, which can selectively illuminate cancer cells. In the present report, we demonstrate that targeting a triple-negative high-invasive human breast cancer, orthotopically-growing in nude mice, with OBP-401 enables curative fluorescence-guided surgery (FGS). OBP-401 enabled complete resection and prevented local recurrence and greatly inhibited lymph-node metastasis due to the ability of the virus to selectively label and subsequently kill cancer cells. In contrast, residual breast cancer cells become more aggressive after bright (white)-light surgery (BLS). OBP-401-based FGS also improved the overall survival compared with conventional BLS. Thus, metastasis from a highly-aggressive triple-negative breast cancer can be prevented by FGS in a clinically-relevant mouse model.

Published
2016

18. Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models

Author

Yano, Shuya, Takehara, Kiyoto, Kishimoto, Hiroyuki, Urata, Yasuo, Kagawa, Shunsuke, Bouvet, Michael, Fujiwara, Toshiyoshi, and Hoffman, Robert M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Rare Diseases, Adenoviridae, Animals, Cell Line, Tumor, Disease Models, Animal, Fluorescence, Humans, Melanoma, Experimental, Mice, Mice, Nude, Neoplasm Recurrence, Local, Optical Imaging, melanoma, nude mice, fluorescence-guided surgery, adenovirus, OBP-401, Oncology and carcinogenesis
Abstract

Malignant melanoma requires precise resection in order to avoid metastatic recurrence. We report here that the telomerase-dependent, green fluorescent protein (GFP)-containing adenovirus OBP-401 could label malignant melanoma with GFP in situ in orthotopic mouse models. OBP-401-based fluorescence-guided surgery (FGS) resulted in the complete resection of malignant melanoma in the orthotopic models, where conventional bright-light surgery (BLS) could not. High-dose administration of OBP-401 enabled FGS without residual cancer cells or recurrence, due to its dual effect of cancer-cell labeling with GFP and killing.

Published
2016

19. Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model.

Author

Yano, Shuya, Takehara, Kiyoto, Miwa, Shinji, Kishimoto, Hiroyuki, Hiroshima, Yukihiko, Murakami, Takashi, Urata, Yasuo, Kagawa, Shunsuke, Bouvet, Michael, Fujiwara, Toshiyoshi, and Hoffman, Robert M

Subjects
Cell Line, Tumor, Animals, Humans, Mice, Nude, Adenoviridae, Colonic Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Telomerase, Green Fluorescent Proteins, Cell Line, Tumor, Mice, Nude, General Science & Technology
Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in situ in an orthotopic mouse model enabling successful FGS. OBP-401-GFP-labeled liver metastasis resulted in complete resection with FGS, in contrast, conventional bright-light surgery (BLS) did not result in complete resection of the metastasis. OBP-401-FGS reduced the recurrence rate and prolonged over-all survival compared with BLS. In conclusion, adenovirus OBP-401 is a powerful tool to label liver metastasis in situ with GFP which enables its complete resection, not possible with conventional BLS.

Published
2016

21. Intraperitoneal Administration of p53-armed Oncolytic Adenovirus Inhibits Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells

Author

HORI, NAOTO, primary, TAZAWA, HIROSHI, additional, LI, YUNCHENG, additional, OKURA, TOMOHIRO, additional, KIKUCHI, SATORU, additional, KURODA, SHINJI, additional, OHARA, TOSHIAKI, additional, NOMA, KAZUHIRO, additional, NISHIZAKI, MASAHIKO, additional, URATA, YASUO, additional, KAGAWA, SHUNSUKE, additional, and FUJIWARA, TOSHIYOSHI, additional

Published
2023
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22. Precise navigation surgery of tumours in the lung in mouse models enabled by in situ fluorescence labelling with a killer-reporter adenovirus

Author

Yano, Shuya, Zhang, Yong, Miwa, Shinji, Kishimoto, Hiroyuki, Urata, Yasuo, Bouvet, Michael, Kagawa, Shunsuke, Fujiwara, Toshiyoshi, and Hoffman, Robert M

Subjects
Cancer, Lung Cancer, Lung, Imaging/CT MRI etc, Non-Small Cell Lung Cancer, Thoracic Surgery
Abstract

BackgroundCurrent methods of image-guided surgery of tumours of the lung mostly rely on CT. A sensitive procedure of selective tumour fluorescence labelling would allow simple and high-resolution visualisation of the tumour for precise surgical navigation.MethodsHuman lung cancer cell lines H460 and A549 were genetically transformed to express red fluorescent protein (RFP). Tumours were grown subcutaneously for each cell line and harvested and minced for surgical orthotopic implantation on the left lung of nude mice. Tumour growth was measured by fluorescence imaging. After the tumours reached 5 mm in diameter, they were injected under fluorescence guidance with the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus, OBP-401. Viral labelling of the lung tumours with GFP precisely colocalised with tumour RFP expression. Three days after administration of OBP-401, fluorescence-guided surgery (FGS) was performed.ResultsFGS of tumours in the lung was enabled by labelling with a telomerase-dependent adenovirus containing the GFP gene. Tumours in the lung were selectively and brightly labelled. FGS enabled complete lung tumour resection with no residual fluorescent tumour.ConclusionsFGS of tumours in the lung is feasible and more effective than bright-light surgery.

Published
2015

23. Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus

Author

Yano, Shuya, Miwa, Shinji, Kishimoto, Hiroyuki, Toneri, Makoto, Hiroshima, Yukihiko, Yamamoto, Mako, Bouvet, Michael, Urata, Yasuo, Tazawa, Hiroshi, Kagawa, Shunsuke, Fujiwara, Toshiyoshi, and Hoffman, Robert M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Brain Cancer, Brain Disorders, Cancer, Neurosciences, Adenoviridae, Animals, Cell Line, Tumor, Disease Models, Animal, Disease-Free Survival, Fluorescence, Glioblastoma, Green Fluorescent Proteins, Humans, Mice, Mice, Nude, Neoplasm Recurrence, Local, Optical Imaging, Biological Sciences, Technology, Medical and Health Sciences, Biotechnology, Genetics, Clinical sciences, Medical biotechnology
Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.

Published
2015

24. Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma

Author

Yano, Shuya, Miwa, Shinji, Kishimoto, Hiroyuki, Uehara, Fuminari, Tazawa, Hiroshi, Toneri, Makoto, Hiroshima, Yukihiko, Yamamoto, Mako, Urata, Yasuo, Kagawa, Shunsuke, Bouvet, Michael, Fujiwara, Toshiyoshi, and Hoffman, Robert M

Subjects
Cancer, Rare Diseases, Adenoviridae, Animals, Cell Line, Tumor, Cells, Cultured, Fluorescence, Genetic Vectors, Green Fluorescent Proteins, Luminescent Agents, Luminescent Proteins, Mice, Mice, Nude, Optical Imaging, Sarcoma, Experimental, Soft Tissue Neoplasms, Surgery, Computer-Assisted, soft tissue sarcoma, nude mice, fluorescence-guided surgery, adenovirus, OBP-401, Oncology and Carcinogenesis
Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense interest. However, FGS of cancer has not yet been shown to be curative due to residual microscopic disease. Human fibrosarcoma HT1080 expressing red fluorescent protein (RFP) was implanted orthotopically in the quadriceps femoris muscle of nude mice. The tumor-bearing mice were injected with high and low-dose telomerase-dependent, green fluorescent protein (GFP)-containing adenovirus OBP-401, which labeled the tumor with GFP. Fluorescence-guided surgery (FGS) or bright light surgery (BLS) was then performed. OBP-401 could label soft-tissue sarcoma (STS) with GFP in situ, concordant with RFP. OBP-401-based FGS resulted in superior resection of STS in the orthotopic model of soft-tissue sarcoma, compared to BLS. High-dose administration of OBP-401 enabled FGS without residual sarcoma cells or local or metastatic recurrence, due to its dual effect of cancer-cell labeling with GFP and killing. High-dose OBP-401 based-FGS improved disease free survival (p = 0.00049) as well as preserved muscle function compared with BLS. High-dose OBP-401-based FGS could cure STS, a presently incurable disease. Since the parent virus of OBP-401, OBP-301, has been previously proven safe in a Phase I clinical trial, it is expected the OBP-401-FGS technology described in the present report should be translatable to the clinic in the near future.

Published
2015

26. Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer

Author

Kajiwara, Yoshinori, Tazawa, Hiroshi, Yamada, Motohiko, Kanaya, Nobuhiko, Fushimi, Takuro, Kikuchi, Satoru, Kuroda, Shinji, Ohara, Toshiaki, Noma, Kazuhiro, Yoshida, Ryuichi, Umeda, Yuzo, Urata, Yasuo, Kagawa, Shunsuke, and Fujiwara, Toshiyoshi

Subjects
Cancer Research, Oncolytic virus, Oncology, MDSC, Immunology, Immunology and Allergy, GM-CSF, Pancreatic cancer, Chemoresistance
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is often refractory to treatment with gemcitabine (GEM) and immune checkpoint inhibitors including anti-programmed cell death ligand 1 (PD-L1) antibody. However, the precise relationship between GEM-resistant PDAC and development of an immunosuppressive tumor microenvironment (TME) remains unclear. In this study, we investigated the immunosuppressive TME in parental and GEM-resistant PDAC tumors and assessed the therapeutic potential of combination therapy with the telomerase-specific replication-competent oncolytic adenovirus OBP-702, which induces tumor suppressor p53 protein and PD-L1 blockade against GEM-resistant PDAC tumors. Mouse PDAC cells (PAN02) and human PDAC cells (MIA PaCa-2, BxPC-3) were used to establish GEM-resistant PDAC lines. PD-L1 expression and the immunosuppressive TME were analyzed using parental and GEM-resistant PDAC cells. A cytokine array was used to investigate the underlying mechanism of immunosuppressive TME induction by GEM-resistant PAN02 cells. The GEM-resistant PAN02 tumor model was used to evaluate the antitumor effect of combination therapy with OBP-702 and PD-L1 blockade. GEM-resistant PDAC cells exhibited higher PD-L1 expression and produced higher granulocyte-macrophage colony-stimulating factor (GM-CSF) levels compared with parental cells, inducing an immunosuppressive TME and the accumulation of myeloid-derived suppressor cells (MDSCs). OBP-702 significantly inhibited GEM-resistant PAN02 tumor growth by suppressing GM-CSF-mediated MDSC accumulation. Moreover, combination treatment with OBP-702 significantly enhanced the antitumor efficacy of PD-L1 blockade against GEM-resistant PAN02 tumors. The present results suggest that combination therapy involving OBP-702 and PD-L1 blockade is a promising antitumor strategy for treating GEM-resistant PDAC with GM-CSF-induced immunosuppressive TME formation.

Published
2022

29. Supplementary Methods and Figure Legend from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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30. Supplementary Figure 4 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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31. Data from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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32. Supplementary Figures S1-S2 from Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer

Author

Takehara, Kiyoto, primary, Tazawa, Hiroshi, primary, Okada, Naohiro, primary, Hashimoto, Yuuri, primary, Kikuchi, Satoru, primary, Kuroda, Shinji, primary, Kishimoto, Hiroyuki, primary, Shirakawa, Yasuhiro, primary, Narii, Nobuhiro, primary, Mizuguchi, Hiroyuki, primary, Urata, Yasuo, primary, Kagawa, Shunsuke, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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33. Supplementary Figure 2 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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34. Supplementary Movie from Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer

Author

Takehara, Kiyoto, primary, Tazawa, Hiroshi, primary, Okada, Naohiro, primary, Hashimoto, Yuuri, primary, Kikuchi, Satoru, primary, Kuroda, Shinji, primary, Kishimoto, Hiroyuki, primary, Shirakawa, Yasuhiro, primary, Narii, Nobuhiro, primary, Mizuguchi, Hiroyuki, primary, Urata, Yasuo, primary, Kagawa, Shunsuke, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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35. Supplementary Figure 6 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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36. Data from Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer

Author

Takehara, Kiyoto, primary, Tazawa, Hiroshi, primary, Okada, Naohiro, primary, Hashimoto, Yuuri, primary, Kikuchi, Satoru, primary, Kuroda, Shinji, primary, Kishimoto, Hiroyuki, primary, Shirakawa, Yasuhiro, primary, Narii, Nobuhiro, primary, Mizuguchi, Hiroyuki, primary, Urata, Yasuo, primary, Kagawa, Shunsuke, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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37. Supplementary Figure 3 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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38. Supplementary Figure 5 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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39. Supplementary Figure 1 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author

Hasei, Joe, primary, Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Osaki, Shuhei, primary, Yamakawa, Yasuaki, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Onishi, Teppei, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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40. Supplementary Movie S2 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G2/M Phases

Author

Yano, Shuya, primary, Tazawa, Hiroshi, primary, Hashimoto, Yuuri, primary, Shirakawa, Yasuhiro, primary, Kuroda, Shinji, primary, Nishizaki, Masahiko, primary, Kishimoto, Hiroyuki, primary, Uno, Futoshi, primary, Nagasaka, Takeshi, primary, Urata, Yasuo, primary, Kagawa, Shunsuke, primary, Hoffman, Robert M., primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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41. Supplementary Information from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G2/M Phases

Author

Yano, Shuya, primary, Tazawa, Hiroshi, primary, Hashimoto, Yuuri, primary, Shirakawa, Yasuhiro, primary, Kuroda, Shinji, primary, Nishizaki, Masahiko, primary, Kishimoto, Hiroyuki, primary, Uno, Futoshi, primary, Nagasaka, Takeshi, primary, Urata, Yasuo, primary, Kagawa, Shunsuke, primary, Hoffman, Robert M., primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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44. Supplementary Data from Preclinical Evaluation of Telomerase-Specific Oncolytic Virotherapy for Human Bone and Soft Tissue Sarcomas

Author

Sasaki, Tsuyoshi, primary, Tazawa, Hiroshi, primary, Hasei, Jo, primary, Kunisada, Toshiyuki, primary, Yoshida, Aki, primary, Hashimoto, Yuuri, primary, Yano, Shuya, primary, Yoshida, Ryosuke, primary, Uno, Futoshi, primary, Kagawa, Shunsuke, primary, Morimoto, Yuki, primary, Urata, Yasuo, primary, Ozaki, Toshifumi, primary, and Fujiwara, Toshiyoshi, primary

Published
2023
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