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1. Gadolinium-Based Contrast Agents Hypersensitivity: A Case Series

Author

Nucera E, Urbani S, Buonomo A, De Pasquale T, Rizzi A, Aruanno A, and Pucci S

Subjects
gadolinium-based contrast agents, hypersensitivity, ige-mediated reactions, Immunologic diseases. Allergy, RC581-607
Abstract

Eleonora Nucera,1 Sara Urbani,1 Alessandro Buonomo,1 Tiziana De Pasquale,2 Angela Rizzi,1 Arianna Aruanno,1 Stefano Pucci2 1Allergy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 2Civitanova Marche Hospital, Civitanova Marche, ItalyCorrespondence: Eleonora NuceraAllergy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito, 1, Rome, 00168, ItalyTel +39 3394475931Fax +06 30156999Email eleonora.nucera@policlinicogemelli.itAbstract: Gadolinium-based contrast agents (GBCAs) are considered to be safe, although sometimes patients report a hypersensitivity reaction when undergoing magnetic resonance imaging (MRI). The mechanisms of these reactions and of the sensitization to GBCAs are still largely unknown. We describe four cases of patients who experienced immediate adverse reactions to GBCAs with a demonstrated cutaneous hypersensitivity suggesting an IgE-mediated mechanism.Keywords: gadolinium-based contrast agents, hypersensitivity, IgE-mediated reactions

Published
2021

5. Clinical and quality of life assessment in patients with latex allergy during COVID-19 pandemic: Possible protective role of continuous latex immunotherapy

Author

Di Rienzo, A, Urbani, Sara, Longhino, David, Sarnari, Caterina, Buonomo, Alessandro, Rizzi, Angela, Aruanno, Arianna, Nucera, Eleonora, Urbani, S, Longhino, D, Sarnari, C, Buonomo, A, Rizzi, A (ORCID:0000-0002-6795-746X), Aruanno, A, Nucera, E (ORCID:0000-0002-0565-7680), Di Rienzo, A, Urbani, Sara, Longhino, David, Sarnari, Caterina, Buonomo, Alessandro, Rizzi, Angela, Aruanno, Arianna, Nucera, Eleonora, Urbani, S, Longhino, D, Sarnari, C, Buonomo, A, Rizzi, A (ORCID:0000-0002-6795-746X), Aruanno, A, and Nucera, E (ORCID:0000-0002-0565-7680)

Abstract

Introduction: During COVID-19 pandemic, the massive use of Personal Protective Equipment could provoke severe adverse reactions in latex allergy patients and could negatively affect their quality of life. Methods: Trough a survey the study aimed: (a) to evaluate the incidence of allergic reactions in patients with latex allergy during the SARS-CoV-2 pandemic; (b) to evaluate the protective role of continuous latex sublingual immunotherapy (SLIT) during this period; and (c) to evaluate quality of life of natural rubber latex allergy (NRLA) patients during the pandemic. Results: 67 patients (9 males and 58 females, mean age of 45.9 +/- 11.4 years) suffering from latex allergy were included in the present study. We recorded among our patients 13 cases (34.2%) of urticarial/angioedema (U/A), 9 cases (23.6%) of respiratory symptoms (dyspnoea, shortness of breath and wheezing) and 7 cases (18.4%) of anaphylaxis. In patients who underwent continuous SLIT, we observed less cases of U/A (p < 0.001), respiratory symptoms (p < 0.001), anaphylaxis (p = 0.003), hospitalizations (p = 0.014) and a lower therapy administration. We compared the results of SF-36 questionnaire in patients who underwent continuous and not-continuous SLIT with a significance differences score between these two groups. Conclusions: Our study is the first that investigated the clinical and quality of life effects of COVID-19 pandemic in NRLA patients.

Published
2022

6. Antiviral Cell-Mediated Immune Responses During Hepatitis B and Hepatitis C Virus Infections

Author

Ferrari, C., Penna, A., Bertoletti, A., Cavalli, A., Missale, G., Lamonaca, V., Boni, C., Valli, A., Bertoni, R., Urbani, S., Scognamiglio, P., Fiaccadori, F., Schlag, P. M., editor, Senn, H.-J., editor, Diehl, V., editor, Parkin, D. M., editor, Rajewsky, M. F., editor, Rubens, R., editor, Wannenmacher, M., editor, Schwab, Manfred, editor, Rabes, Hartmut M., editor, Munk, Klaus, editor, and Hofschneider, Hans Peter, editor

Published
1998
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7. Modeling Intra-Caldera Resurgence Settings: Laboratory Experiments With Application to the Los Humeros Volcanic Complex (Mexico)

Author

Bonini M.[1], Maestrelli D.[1], Corti G.[1], Del Ventisette C.[1, Moratti G.[1], Carrasco-Núñez G.[3], Giordano G.[4], Lucci F.[4], Norini G.[5], Piccardi L.[1], Urbani S.[4], Montanari D.[1], Bonini, M., Maestrelli, D., Corti, G., Del Ventisette, C., Moratti, G., Carrasco-Nunez, G., Giordano, G., Lucci, F., Norini, G., Piccardi, L., Urbani, S., and Montanari, D.

Subjects
fault, geography, geography.geographical_feature_category, Geochemistry, Structural deformation, active extension, deformation style, Central Apennines, negative fault reactivation, analogue models, analogue modeling, Los Humeros Volcanic Complex (Mexico), Geophysics, Volcano, Space and Planetary Science, Geochemistry and Petrology, Earth and Planetary Sciences (miscellaneous), caldera resurgence, Caldera, caldera collapse, Mexico, Geology, Los Humero
Abstract

Scaled analogue models explored the role of different boundary conditions in intra‐caldera resurgence processes. Models investigated the role of magma intrusion depth (Series 1), asymmetric and symmetric caldera collapse (Series 2), as well as the presence of existing discontinuities in the pre‐volcanic substratum (Series 3) on the style of caldera resurgence. Experimental results indicate that different intrusion depths resulted in different resurgence styles and structural patterns, which evolved from piston‐like resurgence, for deeper intrusions, to intra‐caldera resurgent domes for shallower intrusions. Asymmetric collapse was typically accompanied by a tilted roof block above the emptied analogue magma reservoir, while inherited faults influenced significantly the deformation pattern of piston‐like resurgence. Experiments simulate many of the principal characteristics of calderas. We compare our modelling results primarily to the Los Potreros caldera nested within the Los Humeros Volcanic Complex, where the largest Mexico’s Quaternary eruption occurred and which hosts an important geothermal field (eastern Trans‐Mexican Volcanic Belt). A structural field survey was conducted to identify the kinematics of faults within the caldera and outside the volcanic edifice. The Los Potreros caldera shows a sub‐orthogonal fault pattern strikingly similar to that of models deformed with shallow intrusion depth. We interpret this correlation as an evidence of similarity in dynamic processes, whereby modelling results would indicate a scaled intrusion depth of approximately 4.5 km. The Acoculco caldera complex, in Mexico, shows a fault pattern similar to the Los Potreros caldera, and geological information corroborates the attribution of renewed magmatic pressure to similar intrusion depths.

Published
2021
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13. Gadolinium-based contrast agents hypersensitivity: A case series

Author

Nucera, Eleonora, Urbani, Sara, Buonomo, Alessandro, De Pasquale, Tiziana Maria Angela, Rizzi, Angela, Aruanno, A., Pucci, S., Nucera E. (ORCID:0000-0002-0565-7680), Urbani S., Buonomo A., De Pasquale T., Rizzi A. (ORCID:0000-0002-6795-746X), Nucera, Eleonora, Urbani, Sara, Buonomo, Alessandro, De Pasquale, Tiziana Maria Angela, Rizzi, Angela, Aruanno, A., Pucci, S., Nucera E. (ORCID:0000-0002-0565-7680), Urbani S., Buonomo A., De Pasquale T., and Rizzi A. (ORCID:0000-0002-6795-746X)

Abstract

Gadolinium-based contrast agents (GBCAs) are considered to be safe, although sometimes patients report a hypersensitivity reaction when undergoing magnetic resonance imaging (MRI). The mechanisms of these reactions and of the sensitization to GBCAs are still largely unknown. We describe four cases of patients who experienced immediate adverse reactions to GBCAs with a demonstrated cutaneous hypersensitivity suggesting an IgE-mediated mechanism.

Published
2021

16. Corrigendum: Changes in Polyphenolic Concentrations of Table Olives (cv. Itrana) Produced Under Different Irrigation Regimes During Spontaneous or Inoculated Fermentation (Frontiers in Microbiology, (2018), 9, 10.3389/fmicb.2018.01287)

Author

Perpetuini, G., Caruso, G., Urbani, S., Schirone, M., Esposto, S., Ciarrocchi, A., Prete, R., Garcia-Gonzalez, N., Battistelli, N., Gucci, R., Servili, M., Tofalo, R., and Corsetti, A.

Subjects
oleuropein, starter cultures, Itrana, phenolic compounds, table olive, irrigation
Published
2020

17. Adverse reaction to Ficus Carica: reported case of a possible cross-reactivity with Der p1

Author

Urbani, Sara, Aruanno, A, Nucera, Eleonora, Urbani, S, Nucera, E (ORCID:0000-0002-0565-7680), Urbani, Sara, Aruanno, A, Nucera, Eleonora, Urbani, S, and Nucera, E (ORCID:0000-0002-0565-7680)

Abstract

Background: Ficus carica is an edible fruit, belonging to the Moraceae family, rarely described as cause of food allergy. We describe the first case of fig allergy that occurred as a cross-reactivity between fig and Derp 1. Case presentation: We present a case of a 10-years-old-girl, with a history of no-seasonal mild intermittent rhinitis, who experienced an immediate reaction after ingestion of a fresh fig. Skin prick tests (SPT) with commercial extracts of food, airborne allergens, latex and panallergens (profilin, PR-10 and lipid transfer protein) were performed. SPT revealed a sensitization only for dermatophagoides farina and dermatophagoides pteronyssinus which was then confirmed with by specific IgE assay (UniCAP, Phadia, Uppsala, Sweden). We also carried out a positive SPT with a commercial fig allergen (Lofarma, Milan, Italy) and prick-by-prick (PBP) both with skin and pulp of green raw and cooked fig. Fig specific serum IgE levels were 1.08 U/ml and specific IgE for rDer p1 was 16.20 U/ml (total serum IgE = 377 U/ ml). In contrast specific IgE levels for latex, LTP, profilin, PR-10 and pollen allergens were negative. Conclusion: The ficin, the major fig allergen, belongs to cysteine protease family like Der p 1. The symptoms presented by our patient could be related to a cross reactivity between these two proteins which present a structural homology.

Published
2020

18. Eosinophilic Esophagitis During Latex Desensitization

Author

Nucera, Eleonora, Urbani, Sara, Buonomo, Alessandro, Andriollo, Gloria, Aruanno, A, Nucera, E (ORCID:0000-0002-0565-7680), Urbani, S, Buonomo, A, Andriollo, G, Nucera, Eleonora, Urbani, Sara, Buonomo, Alessandro, Andriollo, Gloria, Aruanno, A, Nucera, E (ORCID:0000-0002-0565-7680), Urbani, S, Buonomo, A, and Andriollo, G

Abstract

Latex allergy is a relevant clinical problem observed especially among health-care workers, spina bifida patients and individuals who had multiple surgical procedures. Type I hypersensitivity latex reactions are more frequent than type IV (latex allergic contact dermatitis) and consist of skin involvement (urticaria and/or angioedema), respiratory symptoms (asthma/rhinitis) to systemic anaphylaxis. Thoseare elicited by direct contact with natural rubber latex items (i.e. medical devices) or by inhalation of latex airborne proteins. After diagnosis, prevention is the standard and best measure, but the strict avoidance is often impossible. Therefore in selected cases, the sublingual immunotherapy (SLIT) may be a therapeutic approach able to influence the long-term natural history of latex allergy [1]. During SLIT, immediate adverse reactions have often been reported [2], but long-term complication are less described. We showed the case of an eosinophilic esophagitis (EoE) occurring after 3 years of latex SLIT

Published
2020

32. Immunological aspects of atherosclerosis

Author

Garrido-Urbani, S., Meguenani, M., Montecucco, F., Imhof, B., Garrido-Urbani, S., Meguenani, M., Montecucco, F., and Imhof, B.

Abstract

Atherosclerosis is a complex chronic inflammatory and metabolic disease that involves the collaboration of several cellular components of the immune system and results in thickening of the arterial wall. Atherosclerosis is also the primary cause of coronary artery and cerebrovascular diseases. A multitude of immune cell subsets, soluble molecules such as chemokines and cytokines, and circulating lipids play pivotal roles in atherosclerosis development. In this review, we highlight the role of the immune system in the course of atherosclerotic disease development and discuss the mechanisms involved.

Published
2019

33. Tight junction dynamics: the role of junctional adhesion molecules (JAMs)

Author

Garrido-Urbani, S., Bradfield, P., Imhof, B., Garrido-Urbani, S., Bradfield, P., and Imhof, B.

Abstract

Junctional adhesion molecules (JAMs) are a family of adhesion molecules localized at the tight junction of polarized cells and on the cell surface of leukocytes. The last 20years of research in this field has shown that several members of the family play an important role in the regulation of cell polarity, endothelium permeability and leukocytes migration. They mediate these pleiotropic functions through a multitude of homophilic and heterophilic interactions with intrafamily and extrafamily partners. In this article, we review the current status of the JAM family and highlight their functional role in tight junction dynamics and leukocyte transmigration.

Published
2019

39. Supplementary Material for Analogue Experiments on Lateral versus Vertical Dike Propagation

Author

Urbani, S., Acocella, V., and Rivalta, E.

Abstract

The dataset includes movies of 29 analogue experiments performed to investigate the effects on dike propagation by the following imposed parameters: density ratio between host-rock and magma analogues, rigidity layering and density layering of the host medium, flow rate and topography. The purpose of the experiments is to define a hierarchy of all the parameters considered, by varying systematically each of them, comparing semi-quantitatively the variations on dike geometry and velocity. Experimental setup The experimental set-up consists of a 33 × 58 × 38.5 cm3 Plexiglas box and a peristaltic pump that injects water (magma analogue) into pig-skin gelatin (crustal analogue) alternatively from the bottom (Set 1) and the side of the box (Set 2). The gelatin rheological properties are varied by mixing different concentrations of gelatin powder and NaCl. We refer to “rigidity layering” when the rigidity ratio (i.e. Young’s Modulus) between the upper and lower layer (Eu/El) is < or > 1, and to “density layering” when Eu/El ~ 1, but the two layers show different densities (i.e. the ratio between the density of the upper and lower layer, ρU/ρL). The experiments with topography are prepared by imposing a mold with gently inward dipping flanks (2.4° and 3.7°) on the opposite sides of the box separated by a 8 cm wide horizontal plain on the gelatin surface. This configuration simulates the 2-D along-strike topography of the 2014 Bardarbunga intrusion (Iceland) and allows investigating the role of two opposite slopes on dike propagation. The topography profile dips parallel to the long side of the Plexiglas box (x axis in Figure 1 of Urbani et al. 2018). The flow rate has been changed between 0.079 and 0.435 ml/s. For the details about the model set-up, experimental results and interpretation refer to Urbani et al. (2018). The time-lapse movies show the time evolution of the dike shape, in side and map view, of 29 out of 33 models presented in Urbani et al. (2018). It is recommended to open the films with the VLC media player. The time-lapse of each experiment is indicated in the bottom left corner. A full list of files is given in “Experiments_Summary_2018-012.pdf” in which Set 1 (bottom injection) and Set 2 (lateral injection) experiments are indicated in red and blue color respectively. The same file also provides a summary of the boundary conditions imposed in each experiment. Tu and Tl indicate the thickness of the upper and lower layer respectively.

Published
2018

41. Histopathology of the skin in rheumatic diseases

Author

Chimenti, M. S., Di Stefani, Alessandro, Conigliaro, P., Saggini, A., Urbani, Sara, Giunta, A., Esposito, M., Bianchi, L., Peris, Ketty, Perricone, R., Di Stefani A., Urbani S., Peris K. (ORCID:0000-0002-5237-0463), Chimenti, M. S., Di Stefani, Alessandro, Conigliaro, P., Saggini, A., Urbani, Sara, Giunta, A., Esposito, M., Bianchi, L., Peris, Ketty, Perricone, R., Di Stefani A., Urbani S., and Peris K. (ORCID:0000-0002-5237-0463)

Abstract

Rheumatological systemic autoimmune diseases, such as connective tissue diseases, rheumatoid arthritis or spondyloarthritis, are characterized by the presence of joint involvement associated with extra-articular manifestations. Among them, cutaneous diseases are often the most relevant and representative clinical manifestation, as in psoriatic arthritis, scleroderma or systemic lupus erythematosus. In this context, it is useful for rheumatologists to understand better skin diseases and their histopathological features. Evaluation of skin biopsy specimens can be helpful not only to confirm the diagnosis in both classic and clinically atypical variants, but also to improve further our knowledge of the pathogenetic mechanisms and the close link between skin and articular diseases. In this review, we discuss the clinical features, diagnostic evaluation and the histopathological features of skin manifestation of the most relevant rheumatological autoimmune diseases.

Published
2018

42. Histopathology of the skin in rheumatic diseases

Author

Chimenti, M.S., primary, Di Stefani, A., additional, Conigliaro, P., additional, Saggini, A., additional, Urbani, S., additional, Giunta, A., additional, Esposito, M., additional, Bianchi, L., additional, Peris, K., additional, and Perricone, R., additional

Published
2018
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44. Senescent adipocytes as potential effectors of muscle cells dysfunction: An in vitro model

Author

Zoico Elena, Saatchi Tanaz, Nori Nicole, Mazzali Gloria, Rizzatti Vanni, Pizzi Eleonora, Fantin Francesco, Giani Anna, Urbani Silvia, and Zamboni Mauro

Subjects
Aging, Adipose tissue, Skeletal muscle, Senescence, Myostatin, Medicine, Biology (General), QH301-705.5
Abstract

Recently, there has been a growing body of evidence showing a negative effect of the white adipose tissue (WAT) dysfunction on the skeletal muscle function and quality. However, little is known about the effects of senescent adipocytes on muscle cells.Therefore, to explore potential mechanisms involved in age-related loss of muscle mass and function, we performed an in vitro experiment using conditioned medium obtained from cultures of mature and aged 3 T3-L1 adipocytes, as well as from cultures of dysfunctional adipocytes exposed to oxidative stress or high insulin doses, to treat C2C12 myocytes.The results from morphological measures indicated a significant decrease in diameter and fusion index of myotubes after treatment with medium of aged or stressed adipocytes. Aged and stressed adipocytes presented different morphological characteristics as well as a different gene expression profile of proinflammatory cytokines and ROS production. In myocytes treated with different adipocytes' conditioned media, we demonstrated a significant reduction of gene expression of myogenic differentiation markers as well as a significant increase of genes involved in atrophy. Finally, a significant reduction in protein synthesis as well as a significant increase of myostatin was found in muscle cells treated with medium of aged or stressed adipocytes compared to controls.In conclusion, these preliminary results suggest that aged adipocytes could influence negatively trophism, function and regenerative capacity of myocytes by a paracrine network of signaling.

Published
2023
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48. Proposal for an MRPC system with high-precision timing in the LVD structure

Author

Abbrescia, M, Agafonova, N. Yu, Aglietta, M., Agostinelli, A., Aiola, S., Akindinov, A., Alici, A., Amati, E., Amerigo, S., Angelotti, A. M., Antolini, R., Antonioli, P., Arcelli, S., Asta, A., Atalmi, A., Attanasi, A., Avanzini, C., Baldini Ferroli, R., Bari, G., Bartolucci, S., Belligan, N., Bellini, F., Bencivenni, G., Bessi, C., Boi, M., Bologna, M., Bonardi, A., Bonetti, C., Borromeo, A., Bossini, E., Boyarkin, V. V., Bragagnolo, A., Bressan, E., Brunelli, C., Brunetti, G., Brunos, G., Burato, M., Burzi, S., Calemasi, D., Calvari, F., Cannas, A., Cara Romeo, G., Cardillo, A., Cari, A., Carli, M., Cassinadri, A., Celati, F., Celano, M., Chiaranda, L., Chiavassa, A., Chinnici, L., Cicalo, C., Cifarelli, L., Civili, I., Coccetti, F., Coccia, E., Cocuzza, S., Corti, M., Dambrosio, G., D'Amico, C., De Angelo, N., DE CARO, Annalisa, DE GRUTTOLA, Daniele, Del Chiaro, R., Del Corda, S., Del Corral, F., DE PASQUALE, Salvatore, Deplano, S., Di Giovanni, A., D'Incecco, M., Dispensa, E., Di Carlo, L., Di Crescenzo, E., Di Pietro, F., Di Staso, G., Di Vittorio, P., Dondarini, I., Dreucci, M., Evangelista, M. R., Evans, L., Fabbri, F. L., Falchi, G., Fanti, B., Fantini, A., Fantini, G., Ferrari, S., Finelli, S., Folino, R., Forni, E., Forte, P., Frolov, V., Fulgione, W., FUSCO GIRARD, Mario, La Teana, A., Londrillo, L., Lorenzo, A. R., Lupo, F., Gatti, S., Gaias, A., Galante, L., Galeotti, P., Gallone, M. G., Garbini, M., Gargano, A., Garrisi, M., Gemme, G., Ghia, P. L., Giacconi, P., Giusti, P., Gnesi, I., Guidi, S., Grishuk, Yu, Grotti, M., Guerzoni, B., Gustavino, C., Gustavino, S., Hatzifotiadou, D., Imperio, T., Indelicato, S., Jung, H., Kemp, E., Kim, D. W., Kim, M., Kim, J., Kiselev, S., Kuznetsov, V. V., Kuznetsov, V. A., La Rocca, P., Lee, S., Li, S., Libertini, L., Librizzi, F., Lo Mastro, A., Lucchesi, D., Maccari, A., Maggiora, A., Maggisano, M. P., Magistrale, G., Magli, G., Malguin, A. S., Mal'Kevich, D., Mattina, G., Margotti, A., Maroi, R., Marrone, S., Massai, M., Mastrodomenico, M., Matarese, A., Mazzone, A., Mazzotta, U., Melley, S., Memme, A., Miozzi, S., Moro, R., Murgia, M., Nania, R., Natali, G., Natucci, B., Nedosekin, A., Noferini, F., Nurisso, N., Nuti, S., Paccapelo, A. M., Paccoia, A., Pagano, Paola, Palombella, L., Panareo, M., Paoletti, R., Paravano, A., Pascale, R., Perasso, L., Perrone, D., Persiani, R., Persico, M. C., Pesci, A., Pettini, F., Piazzola, G., Pilo, F., Piragino, G., Pizzigoni, G., Pless, I. A., Porcu, M., Poggi, F., Polverino, E., Porta, A., Pozzanghera, R., Prati, A., Preghenella, R., Pulze, M., Quattromini, O., Ranieri, G., Rebagnati, S., Regano, A., Riggi, F., Righini, G., Rioli, A., Romano, F., Ronchini, L., Rossi, L., Rossi, R., Rossino, M., Rubino, M. G., Ruggeri, A., Russo, G., Ryasny, V. G., Ryazhskaya, O. G., Sartorelli, G., Scapparone, E., Schina, R., Scioli, G., Scribano, A., Selvi, M., Senes, E., Serci, S., Siddi, E., Sivori, G., Spampinato, G., Spandre, G., Squarcia, S., Stirparo, G., Stragiotti, A., Strizzai, L., Taiuti, M., Tarantino, F., Tosello, F., Troiano, C., Urbani, S., Usai, C., Verboso, F., Veseli, A., Vigna, A., Vigorito, C., Voloshin, K., Votano, L., Wenninger, H., Williams, M. C. S., Yakushev, V. F., Zaccaro, M., Zampolli, C., Zarri, I., Ziccardi, A., Zichichi, A., Zoffoli, G., Zouyevski, R., Zucchini, A., Abbrescia, M., Agafonova, N. Y., Aglietta, M., Agostinelli, A., Aiola, S., Akindinov, A., Alici, A., Amati, E., Amerigo, S., Angelotti, A. M., Antolini, R., Antonioli, P., Arcelli, S., Asta, A., Atalmi, A., Attanasi, A., Avanzini, C., Baldini Ferroli, R., Bari, G., Bartolucci, S., Belligan, N., Bellini, F., Bencivenni, G., Bessi, C., Boi, M., Bologna, M., Bonardi, A., Bonetti, C., Borromeo, A., Bossini, E., Boyarkin, V. V., Bragagnolo, A., Bressan, E., Brunelli, C., Brunetti, G., Brunos, G., Burato, M., Burzi, S., Calemasi, D., Calvari, F., Cannas, A., Cara Romeo, G., Cardillo, A., Cari, A., Carli, M., Cassinadri, A., Celati, F., Celano, M., Chiaranda, L., Chiavassa, A., Chinnici, L., Cicalo, C., Cifarelli, L., Civili, I., Coccetti, F., Coccia, E., Cocuzza, S., Corti, M., Dambrosio, G., D'Amico, C., De Angelo, N., De Caro, A., De Gruttola, D., Del Chiaro, R., Del Corda, S., Del Corral, F., De Pasquale, S., Deplano, S., Di Giovanni, A., D'Incecco, M., Dispensa, E., Di Carlo, L., Di Crescenzo, E., Di Pietro, F., Di Staso, G., Di Vittorio, P., Dondarini, I., Dreucci, M., Evangelista, M. R., Evans, L., Fabbri, F. L., Falchi, G., Fanti, B., Fantini, A., Fantini, G., Ferrari, S., Finelli, S., Folino, R., Forni, E., Forte, P., Frolov, V., Fulgione, W., Fusco Girard, M., La Teana, A., Londrillo, L., Lorenzo, A. R., Lupo, F., Gatti, S., Gaias, A., Galante, L., Galeotti, P., Gallone, M. G., Garbini, M., Gargano, A., Garrisi, M., Gemme, G., Ghia, P. L., Giacconi, P., Giusti, P., Gnesi, I., Guidi, S., Grishuk, Y., Grotti, M., Guerzoni, B., Gustavino, C., Gustavino, S., Hatzifotiadou, D., Imperio, T., Indelicato, S., Jung, H., Kemp, E., Kim, D. W., Kim, M., Kim, J., Kiselev, S., Kuznetsov, V. V., Kuznetsov, V. A., La Rocca, P., Lee, S., Li, S., Libertini, L., Librizzi, F., Lo Mastro, A., Lucchesi, D., Maccari, A., Maggiora, A., Maggisano, M. P., Magistrale, G., Magli, G., Malguin, A. S., Mal'Kevich, D., Mattina, G., Margotti, A., Maroi, R., Marrone, S., Massai, M., Mastrodomenico, M., Matarese, A., Mazzone, A., Mazzotta, U., Melley, S., Memme, A., Miozzi, S., Moro, R., Murgia, M., Nania, R., Natali, G., Natucci, B., Nedosekin, A., Noferini, F., Nurisso, N., Nuti, S., Paccapelo, A. M., Paccoia, A., Pagano, P., Palombella, L., Panareo, Marco, Paoletti, R., Paravano, A., Pascale, R., Perasso, L., Perrone, D., Persiani, R., Persico, M. C., Pesci, A., Pettini, F., Piazzola, G., Pilo, F., Piragino, G., Pizzigoni, G., Pless, I. A., Porcu, M., Poggi, F., Polverino, E., Porta, A., Pozzanghera, R., Prati, A., Preghenella, R., Pulze, M., Quattromini, O., Ranieri, G., Rebagnati, S., Regano, A., Riggi, F., Righini, G., Rioli, A., Romano, F., Ronchini, L., Rossi, L., Rossi, R., Rossino, M., Rubino, M. G., Ruggeri, A., Russo, G., Ryasny, V. G., Ryazhskaya, O. G., Sartorelli, G., Scapparone, E., Schina, R., Scioli, G., Scribano, A., Selvi, M., Senes, E., Serci, S., Siddi, E., Sivori, G., Spampinato, G., Spandre, G., Squarcia, S., Stirparo, G., Stragiotti, A., Strizzai, L., Taiuti, M., Tarantino, F., Tosello, F., Troiano, C., Urbani, S., Usai, C., Verboso, F., Veseli, A., Vigna, A., Vigorito, C., Voloshin, K., Votano, L., Wenninger, H., Williams, M. C. S., Yakushev, V. F., Zaccaro, M., Zampolli, C., Zarri, I., Ziccardi, A., Zichichi, A., Zoffoli, G., Zouyevski, R., and Zucchini, A.

Subjects
Physics, Large Hadron Collider, Traverse, Physics::Instrumentation and Detectors, Opera, Detector, Structure (category theory), General Physics and Astronomy, Theoretical physics, Computer engineering, Simple (abstract algebra), High Energy Physics::Experiment, Cosmic muons, Neutrino
Abstract

The purpose of this paper is to present a project in order to verify -without the need of knowing the distance CERN-Gran Sasso- the discovery made by the OPERA Collaboration concerning the speed of the CERN neutrinos. The project consists of two parts. A simple one and a less simple one. Both have the great advantage of being totally independent of the knowledge of the distance, ≃ 732 km, between the two Labs, CERN and LNGS, where the neutrinos are produced and detected, respectively. The "simple" version of this project is based on the high-energy horizontal cosmic muons, which traverse LVD and OPERA detectors, thus allowing to cross-calibrate the timing systems of both experiments in a way which is totally independent of the TOF measurements of CNGS. This component of the project is being studied in collaboration with the OPERA group, as the time stabilities of both experiments are needed. In fact it is since a long time that the two groups are engaged with this problem. In this paper we will present and discuss the "less simple" part which allows to establish, at the highest possible level of accuracy, if (v > c) effects really exist.

Published
2012

50. IMPAIREMENT OF ENDOTHELIAL DIFFERENTIATION FROM MESENCHYMAL STEM CELLS (MSC) IN SYSTEMIC SCLEROSIS (SSC): A NEW TOOL IN PATHOGENETIC MECHANISM

Author

Cipriani, Paola, Guiducci, S., Cinelli, M., Urbani, S., Marrelli, A., Fulminis, A., Pingiotti, E., Liakouli, V., Dolo, Vincenza, Pavan, A., Saccardi, R., Tyndall, A., Matucci Cerenic, M., Giacomelli, Roberto, Paola, Cipriani, Guiducci, S., Cinelli, M., Urbani, S., Marrelli, A., Fulminis, A., Pingiotti, E., Liakouli, V., Vincenza, Dolo, Pavan, A., Saccardi, R., Tyndall, A., Matucci Cerenic, M., and Roberto, Giacomelli

Published
2006

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