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464 results on '"Urbano, F."'

2. Impact of age and gender on the safety and efficacy of chemotherapy plus bevacizumab in metastatic colorectal cancer: a pooled analysis of TRIBE and TRIBE2 studies

Author

Marmorino, F., Rossini, D., Lonardi, S., Moretto, R., Zucchelli, G., Aprile, G., Dell’Aquila, E., Ratti, M., Bergamo, F., Masi, G., Urbano, F., Ronzoni, M., Libertini, M., Borelli, B., Randon, G., Buonadonna, A., Allegrini, G., Pella, N., Ricci, V., Boccaccino, A., Latiano, T.P., Cordio, S., Passardi, A., Tamburini, E., Boni, L., Falcone, A., and Cremolini, C.

Published
2019
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3. Exploring Pediatric Secondary Osteoporosis: The Red Flag of Several Systemic Diseases.

Author

Mangiatordi, S., Ferrante, M., Raspo, A., Capriati, B., Stellacci, G., Urbano, F., Faienza, M. F., and Francavilla, M.

Subjects
OSTEOPOROSIS, VITAMIN D deficiency, DUAL-energy X-ray absorptiometry, ICHTHYOSIS
Abstract

This article explores the topic of pediatric secondary osteoporosis, specifically focusing on vertebral fractures (VFs) and the importance of investigating osteoporosis in children with isolated back pain, as it may indicate underlying systemic diseases. The most common causes of secondary osteoporosis in children are endocrine disorders, gastrointestinal disorders, rheumatologic, oncologic, and renal diseases, medications such as glucocorticoids, and immobility. The diagnosis of childhood osteoporosis relies on dual-energy X-ray absorptiometry (DEXA) and conventional spine radiographs. The article presents two case studies that highlight the importance of early diagnosis and a multidisciplinary approach involving radiologists, pediatricians, and orthopedics in recognizing and treating underlying systemic diseases. [Extracted from the article]

Published
2024
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4. Prognostic and predictive role of neutrophil/lymphocytes ratio in metastatic colorectal cancer: a retrospective analysis of the TRIBE study by GONO

Author

Dell’Aquila, E., Cremolini, C., Zeppola, T., Lonardi, S., Bergamo, F., Masi, G., Stellato, M., Marmorino, F., Schirripa, M., Urbano, F., Ronzoni, M., Tomasello, G., Zaniboni, A., Racca, P., Buonadonna, A., Allegrini, G., Fea, E., Di Donato, S., Chiara, S., Tonini, G., Tomcikova, D., Boni, L., Falcone, A., and Santini, D.

Published
2018
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6. Minimal Lagrangian submanifolds in the complex hyperbolic space

Author

Castro, I., Montealegre, C. R., and Urbano, F.

Subjects
Mathematics - Differential Geometry, 53C42
Abstract

In this paper we construct new examples of minimal Lagrangian submanifolds in the complex hyperbolic space with large symmetry groups, obtaining three 1-parameter families with cohomegeneity one. We characterize them as the only minimal Lagrangian submanifolds in CH^n foliated by umbilical hypersurfaces of Lagrangian subspaces RH^n of CH^n. Several suitable generalizations of the above construction allow us to get new families of minimal Lagrangian submanifolds in CH^n from curves in CH^1 and (n-1)-dimensional minimal Lagrangian submanifolds of the complex space forms CP^n-1, CH^n-1 and C^n-1. Similar constructions are made in the complex projective space., Comment: 28 pages. To appear in Illinois J. Math

Published
2001

7. Analysis of steatosis biomarkers and inflammatory profile after adding on PCSK9 inhibitor treatment in familial hypercholesterolemia subjects with nonalcoholic fatty liver disease

Author

Bosco, G., primary, Di Pino, A., additional, Urbano, F., additional, Ferrara, V., additional, Marchisello, S., additional, Di Mauro, S., additional, Scamporrino, A., additional, Filippello, A., additional, Rabuazzo, A.M., additional, Purrello, F., additional, Piro, S., additional, and Scicali, R., additional

Published
2023
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15. Detection potential of the KM3NeT detector for high-energy neutrinos from the Fermi bubbles

Author

Adrián-Martínez, S., Ageron, M., Aguilar, J.A., Aharonian, F., Aiello, S., Albert, A., Alexandri, M., Ameli, F., Anassontzis, E.G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Assis Jesus, A., Aubert, J.-J., Bakker, R., Ball, A.E., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., de Bel, M., Belias, A., Bellou, N., Berbee, E., Berkien, A., Bersani, A., Bertin, V., Beurthey, S., Biagi, S., Bigongiari, C., Bigourdan, B., Billault, M., de Boer, R., Boer Rookhuizen, H., Bonori, M., Borghini, M., Bou-Cabo, M., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bradbury, S., Brown, A., Bruni, F., Brunner, J., Brunoldi, M., Busto, J., Cacopardo, G., Caillat, L., Calvo Díaz-Aldagalán, D., Calzas, A., Canals, M., Capone, A., Carr, J., Castorina, E., Cecchini, S., Ceres, A., Cereseto, R., Chaleil, Th., Chateau, F., Chiarusi, T., Choqueuse, D., Christopoulou, P.E., Chronis, G., Ciaffoni, O., Circella, M., Cocimano, R., Cohen, F., Colijn, F., Coniglione, R., Cordelli, M., Cosquer, A., Costa, M., Coyle, P., Craig, J., Creusot, A., Curtil, C., D’Amico, A., Damy, G., De Asmundis, R., De Bonis, G., Decock, G., Decowski, P., Delagnes, E., De Rosa, G., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drogou, J., Drouhin, D., Druillole, F., Drury, L., Durand, D., Durand, G.A., Eberl, T., Emanuele, U., Enzenhöfer, A., Ernenwein, J.-P., Escoffier, S., Espinosa, V., Etiope, G., Favali, P., Felea, D., Ferri, M., Ferry, S., Flaminio, V., Folger, F., Fotiou, A., Fritsch, U., Gajanana, D., Garaguso, R., Gasparini, G.P., Gasparoni, F., Gautard, V., Gensolen, F., Geyer, K., Giacomelli, G., Gialas, I., Giordano, V., Giraud, J., Gizani, N., Gleixner, A., Gojak, C., Gómez-González, J.P., Graf, K., Grasso, D., Grimaldi, A., Groenewegen, R., Guédé, Z., Guillard, G., Guilloux, F., Habel, R., Hallewell, G., van Haren, H., van Heerwaarden, J., Heijboer, A., Heine, E., Hernández-Rey, J.J., Herold, B., Hillebrand, T., van de Hoek, M., Hogenbirk, J., Hößl, J., Hsu, C.C., Imbesi, M., Jamieson, A., Jansweijer, P., de Jong, M., Jouvenot, F., Kadler, M., Kalantar-Nayestanaki, N., Kalekin, O., Kappes, A., Karolak, M., Katz, U.F., Kavatsyuk, O., Keller, P., Kiskiras, Y., Klein, R., Kok, H., Kontoyiannis, H., Kooijman, P., Koopstra, J., Kopper, C., Korporaal, A., Koske, P., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Laan, M., La Fratta, C., Lagier, P., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Leisos, A., Lenis, D., Leonora, E., Le Provost, H., Lim, G., Llorens, C.D., Lloret, J., Löhner, H., Lo Presti, D., Lotrus, P., Louis, F., Lucarelli, F., Lykousis, V., Malyshev, D., Mangano, S., Marcoulaki, E.C., Margiotta, A., Marinaro, G., Marinelli, A., Mariş, O., Markopoulos, E., Markou, C., Martínez-Mora, J.A., Martini, A., Marvaldi, J., Masullo, R., Maurin, G., Migliozzi, P., Migneco, E., Minutoli, S., Miraglia, A., Mollo, C.M., Mongelli, M., Monmarthe, E., Morganti, M., Mos, S., Motz, H., Moudden, Y., Mul, G., Musico, P., Musumeci, M., Naumann, Ch., Neff, M., Nicolaou, C., Orlando, A., Palioselitis, D., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Papazoglou, I.A., Păvălaş, G.E., Peek, H.Z., Perkin, J., Piattelli, P., Popa, V., Pradier, T., Presani, E., Priede, I.G., Psallidas, A., Rabouille, C., Racca, C., Radu, A., Randazzo, N., Rapidis, P.A., Razis, P., Real, D., Reed, C., Reito, S., Resvanis, L.K., Riccobene, G., Richter, R., Roensch, K., Rolin, J., Rose, J., Roux, J., Rovelli, A., Russo, A., Russo, G.V., Salesa, F., Samtleben, D., Sapienza, P., Schmelling, J.-W., Schmid, J., Schnabel, J., Schroeder, K., Schuller, J.-P., Schussler, F., Sciliberto, D., Sedita, M., Seitz, T., Shanidze, R., Simeone, F., Siotis, I., Sipala, V., Sollima, C., Sparnocchia, S., Spies, A., Spurio, M., Staller, T., Stavrakakis, S., Stavropoulos, G., Steijger, J., Stolarczyk, Th., Stransky, D., Taiuti, M., Taylor, A., Thompson, L., Timmer, P., Tonoiu, D., Toscano, S., Touramanis, C., Trasatti, L., Traverso, P., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Urbano, F., Vallage, B., Van Elewyck, V., Vannoni, G., Vecchi, M., Vernin, P., Viola, S., Vivolo, D., Wagner, S., Werneke, P., White, R.J., Wijnker, G., Wilms, J., de Wolf, E., Yepes, H., Zhukov, V., Zonca, E., Zornoza, J.D., and Zúñiga, J.

Published
2013
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18. Metastatic Anal Lesion of Primary Lobular Breast Carcinoma- An Insidious, Rare and Subclinical Progression: Case Report and Review of the Literature

Author

Fabbri Nicolò, Aisoni F, Bonazza S, Carcoforo P, D’Urbano F, Pedriali M, and Soliani G

Subjects
medicine.medical_specialty, business.industry, Lobular Breast Carcinoma, Lobular carcinoma, Cancer, Anal canal, medicine.disease, Occult, Metastasis, Breast cancer, medicine.anatomical_structure, General Earth and Planetary Sciences, Medicine, Radiology, business, Breast carcinoma, General Environmental Science
Abstract

Gastrointestinal metastasis from primary breast carcinoma is very uncommon, with less than 1% of breast carcinomas metastasize to the gastrointestinal tract but anorectal involvement is even rarer. These metastatic lesions can lead to diagnostic challenge for clinicians as they can mimic primary colo-rectal cancer due to the lack of diagnostic signs. The increase of patient survival could lead to an unusual late resumption of metastatic disease, often for a long-time occult. Nowadays, an almost completely absent literature is unable to suggest diagnostic pathways capable of predicting this type of disease evolution. We present the case of a 76-year old woman who underwent treatment for an infiltrative lobular carcinoma of the breast who developed metastasis of the anal canal 11- years later. A literature review was performed.

Published
2020
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21. ANTARES: The first undersea neutrino telescope

Author

Ageron, M., Aguilar, J.A., Al Samarai, I., Albert, A., Ameli, F., André, M., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Arnaud, K., Aslanides, E., Assis Jesus, A.C., Astraatmadja, T., Aubert, J.-J., Auer, R., Barbarito, E., Baret, B., Basa, S., Bazzotti, M., Becherini, Y., Beltramelli, J., Bersani, A., Bertin, V., Beurthey, S., Biagi, S., Bigongiari, C., Billault, M., Blaes, R., Bogazzi, C., de Botton, N., Bou-Cabo, M., Boudahef, B., Bouwhuis, M.C., Brown, A.M., Brunner, J., Busto, J., Caillat, L., Calzas, A., Camarena, F., Capone, A., Caponetto, L., Cârloganu, C., Carminati, G., Carmona, E., Carr, J., Carton, P.H., Cassano, B., Castorina, E., Cecchini, S., Ceres, A., Chaleil, Th., Charvis, Ph., Chauchot, P., Chiarusi, T., Circella, M., Compère, C., Coniglione, R., Coppolani, X., Cosquer, A., Costantini, H., Cottini, N., Coyle, P., Cuneo, S., Curtil, C., D'Amato, C., Damy, G., van Dantzig, R., De Bonis, G., Decock, G., Decowski, M.P., Dekeyser, I., Delagnes, E., Desages-Ardellier, F., Deschamps, A., Destelle, J.-J., Di Maria, F., Dinkespiler, B., Distefano, C., Dominique, J.-L., Donzaud, C., Dornic, D., Dorosti, Q., Drogou, J.-F., Drouhin, D., Druillole, F., Durand, D., Durand, R., Eberl, T., Emanuele, U., Engelen, J.J., Ernenwein, J.-P., Escoffier, S., Falchini, E., Favard, S., Fehr, F., Feinstein, F., Ferri, M., Ferry, S., Fiorello, C., Flaminio, V., Folger, F., Fritsch, U., Fuda, J.-L., Galatá, S., Galeotti, S., Gay, P., Gensolen, F., Giacomelli, G., Gojak, C., Gómez-González, J.P., Goret, Ph., Graf, K., Guillard, G., Halladjian, G., Hallewell, G., van Haren, H., Hartmann, B., Heijboer, A.J., Heine, E., Hello, Y., Henry, S., Hernández-Rey, J.J., Herold, B., Hößl, J., Hogenbirk, J., Hsu, C.C., Hubbard, J.R., Jaquet, M., Jaspers, M., de Jong, M., Jourde, D., Kadler, M., Kalantar-Nayestanaki, N., Kalekin, O., Kappes, A., Karg, T., Karkar, S., Karolak, M., Katz, U., Keller, P., Kestener, P., Kok, E., Kok, H., Kooijman, P., Kopper, C., Kouchner, A., Kretschmer, W., Kruijer, A., Kuch, S., Kulikovskiy, V., Lachartre, D., Lafoux, H., Lagier, P., Lahmann, R., Lahonde-Hamdoun, C., Lamare, P., Lambard, G., Languillat, J.-C., Larosa, G., Lavalle, J., Le Guen, Y., Le Provost, H., LeVanSuu, A., Lefèvre, D., Legou, T., Lelaizant, G., Lévéque, C., Lim, G., Lo Presti, D., Loehner, H., Loucatos, S., Louis, F., Lucarelli, F., Lyashuk, V., Magnier, P., Mangano, S., Marcel, A., Marcelin, M., Margiotta, A., Martinez-Mora, J.A., Masullo, R., Mazéas, F., Mazure, A., Meli, A., Melissas, M., Migneco, E., Mongelli, M., Montaruli, T., Morganti, M., Moscoso, L., Motz, H., Musumeci, M., Naumann, C., Naumann-Godo, M., Neff, M., Niess, V., Nooren, G.J.L., Oberski, J.E.J., Olivetto, C., Palanque-Delabrouille, N., Palioselitis, D., Papaleo, R., Păvălaş, G.E., Payet, K., Payre, P., Peek, H., Petrovic, J., Piattelli, P., Picot-Clemente, N., Picq, C., Piret, Y., Poinsignon, J., Popa, V., Pradier, T., Presani, E., Prono, G., Racca, C., Raia, G., van Randwijk, J., Real, D., Reed, C., Réthoré, F., Rewiersma, P., Riccobene, G., Richardt, C., Richter, R., Ricol, J.S., Rigaud, V., Roca, V., Roensch, K., Rolin, J.-F., Rostovtsev, A., Rottura, A., Roux, J., Rujoiu, M., Ruppi, M., Russo, G.V., Salesa, F., Salomon, K., Sapienza, P., Schmitt, F., Schöck, F., Schuller, J.-P., Schüssler, F., Sciliberto, D., Shanidze, R., Shirokov, E., Simeone, F., Sottoriva, A., Spies, A., Spona, T., Spurio, M., Steijger, J.J.M., Stolarczyk, Th., Streeb, K., Sulak, L., Taiuti, M., Tamburini, C., Tao, C., Tasca, L., Terreni, G., Tezier, D., Toscano, S., Urbano, F., Valdy, P., Vallage, B., Van Elewyck, V., Vannoni, G., Vecchi, M., Venekamp, G., Verlaat, B., Vernin, P., Virique, E., de Vries, G., van Wijk, R., Wijnker, G., Wobbe, G., de Wolf, E., Yakovenko, Y., Yepes, H., Zaborov, D., Zaccone, H., Zornoza, J.D., and Zúñiga, J.

Published
2011
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27. A validated prognostic classifier for V600EBRAF-mutated metastatic colorectal cancer: the ‘BRAF BeCool’ study

Author

Loupakis F., Intini R., Cremolini C., Orlandi A., Sartore-Bianchi A., Pietrantonio F., Pella N., Spallanzani A., Dell'Aquila E., Scartozzi M., De Luca E., Rimassa L., Formica V., Leone F., Calvetti L., Aprile G., Antonuzzo L., Urbano F., Prenen H., Negri F., Di Donato S., Buonandi P., Tomasello G., Avallone A., Zustovich F., Moretto R., Antoniotti C., Salvatore L., Calegari M. A., Siena S., Morano F., Ongaro E., Cascinu S., Santini D., Ziranu P., Schirripa M., Buggin F., Prete A. A., Depetris I., Biason P., Lonardi S., Zagonel V., Fassan M., Di Maio M., Loupakis, F., Intini, R., Cremolini, C., Orlandi, A., Sartore-Bianchi, A., Pietrantonio, F., Pella, N., Spallanzani, A., Dell'Aquila, E., Scartozzi, M., De Luca, E., Rimassa, L., Formica, V., Leone, F., Calvetti, L., Aprile, G., Antonuzzo, L., Urbano, F., Prenen, H., Negri, F., Di Donato, S., Buonandi, P., Tomasello, G., Avallone, A., Zustovich, F., Moretto, R., Antoniotti, C., Salvatore, L., Calegari, M. A., Siena, S., Morano, F., Ongaro, E., Cascinu, S., Santini, D., Ziranu, P., Schirripa, M., Buggin, F., Prete, A. A., Depetris, I., Biason, P., Lonardi, S., Zagonel, V., Fassan, M., and Di Maio, M.

Subjects
Adult, Male, Proto-Oncogene Proteins B-raf, Scoring system, DNA Mutational Analysis, Metastases, V600E, BRAF, Colorectal cancer, Prognostic markers, Risk Assessment, Young Adult, Predictive Value of Tests, Risk Factors, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Neoplasm Metastasis, Aged, Retrospective Studies, Aged, 80 and over, Middle Aged, Prognosis, Phenotype, Italy, Mutation, Female, Colorectal Neoplasms
Abstract

Background: Despite the well-known negative prognostic value of the V600EBRAF mutation in patients with metastatic colorectal cancer (mCRC), its outcome is quite heterogeneous, and the basis for this prognostic heterogeneity should be better defined. Methods: Two large retrospective series of V600EBRAF-mutated mCRC from 22 institutions served as an exploratory and validation set to develop a prognostic score. The model was internally and externally validated. Results: A total of 395 V600EBRAF-mutated mCRCs were included in the exploratory set. Performance status, CA19.9, lactate dehydrogenase, neutrophil/lymphocyte ratio, grading and liver, lung and nodal involvement emerged as independent prognostic factors for overall survival (OS). Two different scoring systems were built: a ‘complete’ score (0–16) including all significant covariates and a ‘simplified’ score (0–9), based only on clinicopathological covariates, and excluding laboratory values. Adopting the complete score, proportions of patients with a low (0–4), intermediate (5–8) and high (9–16) score were 44.7%, 42.6% and 12.6%, respectively. The median OS was 29.6, 15.5 (hazard ratio [HR] for intermediate vs low risk: 2.16, 95% confidence interval [CI]: 1.44–3.22, p < .001) and 6.6 months (HR for high vs low risk: 4.72, 95% CI: 2.72–8.20, p < .001). Similar results were observed also after adjusting for the type of first-line treatment and adopting the simplified score. The simplified prognostic score derived from the exploratory set was then applied to the validation set for external confirmation. Conclusions: These scoring systems are based on easy-to-collect data and defined specific subgroups with relevant differences in their life expectancy. These tools could be useful in clinical practice, would allow better stratification of patients in clinical trials and may be adopted for proper adjustments in exploratory translational analyses.

Published
2019

30. Studies of a full-scale mechanical prototype line for the ANTARES neutrino telescope and tests of a prototype instrument for deep-sea acoustic measurements

Author

Ageron, M., Aguilar, J.A., Albert, A., Ameli, F., Anghinolfi, M., Anton, G., Anvar, S., Ardellier-Desages, F., Aslanides, E., Aubert, J.-J., Auer, R., Barbarito, E., Basa, S., Battaglieri, M., Bazzotti, M., Becherini, Y., Béthoux, N., Beltramelli, J., Bertin, V., Bigi, A., Billault, M., Blaes, R., de Botton, N., Bouwhuis, M.C., Bruijn, R., Brunner, J., Burgio, G.F., Busto, J., Cafagna, F., Caillat, L., Calzas, A., Capone, A., Caponetto, L., Carmona, E., Carr, J., Castel, D., Castorina, E., Cavasinni, V., Cecchini, S., Ceres, A., Charvis, P., Chauchot, P., Chiarusi, T., Circella, M., Coail, J.-Y., Colnard, C., Compére, C., Coniglione, R., Cottini, N., Coyle, P., Cuneo, S., Cussatlegras, A.-S., Damy, G., van Dantzig, R., DeBonis, G., De Marzo, C., De Vita, R., Dekeyser, I., Delagnes, E., Denans, D., Deschamps, A., Dessa, J.-X., Destelle, J.-J., Dinkespieler, B., Distefano, C., Donzaud, C., Drogou, J-F., Druillole, F., Durand, D., Ernenwein, J.-P., Escoffier, S., Falchini, E., Favard, S., Fehr, F., Feinstein, F., Fiorello, C., Flaminio, V., Fratini, K., Fuda, J.-L., Galeotti, S., Gallone, J.-M., Giacomelli, G., Girard, N., Gojak, C., Goret, Ph., Graf, K., Guilloux, F., Hallewell, G., Harakeh, M.N., Hartmann, B., Heijboer, A., Heine, E., Hello, Y., Hernández-Rey, J.J., Hößl, J., Hoffman, C., Hogenbirk, J., Hubbard, J.R., Jaquet, M., Jaspers, M., de Jong, M., Jouvenot, F., Kalantar-Nayestanaki, N., Kappes, A., Karg, T., Katz, U., Keller, P., Kneib, J.P., Kok, E., Kok, H., Kooijman, P., Kopper, C., Kouchner, A., Kretschmer, W., Kruijer, A., Kuch, S., Lagier, P., Lahmann, R., Lamanna, G., Lamare, P., Lambard, G., Languillat, J.C., Laschinsky, H., Lavalle, J., Le Guen, Y., Le Provost, H., Le Van Suu, A., Lefévre, D., Legou, T., Lelaizant, G., Lim, G., Lo Presti, D., Loaec, G., Loehner, H., Loucatos, S., Louis, F., Lucarelli, F., Lyashuk, V., Mangano, S., Marcelin, M., Margiotta, A., Masullo, R., Mazéas, F., Mazure, A., Megna, R., Melissas, M., Migneco, E., Mongelli, M., Montaruli, T., Morganti, M., Moscoso, L., Motz, H., Musumeci, M., Naumann, C., Naumann-Godo, M., Niess, V., Noble, A., Olivetto, C., Ostasch, R., Palanque-Delabrouille, N., Payre, P., Peek, H.Z., Perez, A., Petta, C., Piattelli, P., Pillet, R., Pineau, J.-P., Poinsignon, J., Popa, V., Pradier, T., Racca, C., Randazzo, N., van Randwijk, J., Real, D., Regnier, M., van Rens, B., Réthoré, F., Rewiersma, P., Riccobene, G., Rigaud, V., Ripani, M., Roca, V., Roda, C., Rolin, J.F., Rostovtsev, A., Roux, J., Ruppi, M., Russo, G.V., Rusydi, G., Salesa, F., Salomon, K., Sapienza, P., Schmitt, F., Schuller, J.-P., Shanidze, R., Sokalski, I., Spona, T., Spurio, M., van der Steenhoven, G., Stolarczyk, T., Streeb, K., Sulak, L., Taiuti, M., Tamburini, C., Tao, C., Tasca, L., Terreni, G., Urbano, F., Valdy, P., Valente, V., Vallage, B., Vaudaine, G., Venekamp, G., Verlaat, B., Vernin, P., van Wijk, R., Wijnker, G., Wobbe, G., de Wolf, E., Yao, A.-F., Zaborov, D., Zaccone, H., Zornoza, J.D., and Zúñiga, J.

Published
2007
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31. The ANTARES optical beacon system

Author

Ageron, M., Aguilar, J.A., Albert, A., Ameli, F., Anghinolfi, M., Anton, G., Anvar, S., Ardellier-Desages, F., Aslanides, E., Aubert, J-J., Auer, R., Barbarito, E., Basa, S., Battaglieri, M., Becherini, Y., Beltramelli, J., Bertin, V., Bigi, A., Billault, M., Blaes, R., de Botton, N., Bouwhuis, M.C., Bradbury, S.M., Bruijn, R., Brunner, J., Burgio, G.F., Busto, J., Cafagna, F., Caillat, L., Calzas, A., Capone, A., Caponetto, L., Carmona, E., Carr, J., Cartwright, S.L., Castel, D., Castorina, E., Cavasinni, V., Cecchini, S., Ceres, A., Charvis, P., Chauchot, P., Chiarusi, T., Circella, M., Colnard, C., Compère, C., Coniglione, R., Cottini, N., Coyle, P., Cuneo, S., Cussatlegras, A-S., Damy, G., van Dantzig, R., De Bonis, G., De Marzo, C., De Vita, R., Dekeyser, I., Delagnes, E., Denans, D., Deschamps, A., Destelle, J-J., Dinkespieler, B., Distefano, C., Donzaud, C., Drogou, J-F., Druillole, F., Durand, D., Ernenwein, J-P., Escoffier, S., Falchini, E., Favard, S., Fehr, F., Feinstein, F., Ferry, S., Fiorello, C., Flaminio, V., Fratini, K., Fuda, J-L., Galeotti, S., Gallone, J-M., Giacomelli, G., Girard, N., Gojak, C., Goret, Ph., Graf, K., Hallewell, G., Harakeh, M.N., Hartmann, B., Heijboer, A., Heine, E., Hello, Y., Hernández-Rey, J.J., Hößl, J., Hoffman, C., Hogenbirk, J., Hubbard, J.R., Jaquet, M., Jaspers, M., de Jong, M., Jouvenot, F., Kalantar-Nayestanaki, N., Kappes, A., Karg, T., Katz, U., Keller, P., Kok, E., Kok, H., Kooijman, P., Kopper, C., Korolkova, E.V., Kouchner, A., Kretschmer, W., Kruijer, A., Kuch, S., Kudryavstev, V.A., Lagier, P., Lahmann, R., Lamanna, G., Lamare, P., Lambard, G., Languillat, J-C., Laschinsky, H., Lavalle, J., Le Guen, Y., Le Provost, H., Le Van Suu, A., Lefèvre, D., Legou, T., Lelaizant, G., Lim, G., Lo Presti, D., Loehner, H., Loucatos, S., Louis, F., Lucarelli, F., Lyashuk, V., Marcelin, M., Margiotta, A., Masullo, R., Mazéas, F., Mazure, A., McMillan, J.E., Megna, R., Melissas, M., Migneco, E., Milovanovic, A., Mongelli, M., Montaruli, T., Morganti, M., Moscoso, L., Musumeci, M., Naumann-Godo, M., Naumann, C., Niess, V., Noble, T., Olivetto, C., Ostasch, R., Palanque-Delabrouille, N., Payre, P., Peek, H., Perez, A., Petta, C., Piattelli, P., Pillet, R., Pineau, J-P., Poinsignon, J., Popa, V., Pradier, T., Racca, C., Randazzo, N., van Randwijk, J., Real, D., van Rens, B., Réthoré, F., Rewiersma, P., Riccobene, G., Rigaud, V., Ripani, M., Roca, V., Roda, C., Rolin, J.F., Rose, H.J., Rostovtsev, A., Roux, J., Ruppi, M., Russo, G.V., Rusydi, G., Salesa, F., Salomon, K., Sapienza, P., Schmitt, F., Schuller, J-P., Shanidze, R., Sokalski, I., Spona, T., Spurio, M., van der Steenhoven, G., Stolarczyk, T., Streeb, K., Sulak, L., Taiuti, M., Tamburini, C., Tao, C., Terreni, G., Thompson, L.F., Urbano, F., Valdy, P., Valente, V., Vallage, B., Vaudaine, G., Venekamp, G., Verlaat, B., Vernin, P., de Vries-Uiterweerd, G., van Wijk, R., Wijnker, G., de Witt Huberts, P., Wobbe, G., de Wolf, E., Yao, A-F., Zaborov, D., Zaccone, H., Zornoza, J.D., and Zúñiga, J.

Published
2007
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35. COVID-19: identifying the main outcome predictors. A retrospective cohort study in Northern Italy.

Author

GRECO, S., BONSI, B., BELLA, A., FABBRI, N., ROCCHI, C., BELLIO, M. E., MASSOLI, L., GIACCARI, S., GAVIOLI, M., FAZZIN, M., D'URBANO, F., ROSSIN, E., FEO, C. V., PARINI, S., CAVALLESCO, G. N., and PASSARO, A.

Abstract

OBJECTIVE: The need for efficient drugs and early treatment of patients with SARSCoV-2 infection developing COVID-19 symptoms is of primary importance in daily clinical practice and it is certainly among the most difficult medical challenges in the current century. Recognizing those patients who will need stronger clinical efforts could effectively help doctors anticipate the eventual need for intensification of care (IoC) and choose the best treatment in order to avoid worse outcomes. PATIENTS AND METHODS: We enrolled 501 patients, consecutively admitted to our two COVID hospitals, and collected their clinical, anamnestic and laboratory data on admission. The aim of this retrospective study was to identify those data that are strictly associated with COVID-19 outcomes (IoC and in-hospital death) and that could somehow be intended as predictors of these outcomes. This allowed us to provide a "sketch" of the patient who undergoes, more often than others, an intensification of care and/or in-hospital death. RESULTS: Males were found to have a double risk of needing an IoC (OR=2.11) and a significant role was played by both the PaO2/FiO2 ratio on admission (OR=0.99) and serum LDH (OR=1.01). The main predictors of in-hospital death were age (OR=1.08) and the PaO2/FiO2 ratio on admission (OR=0.99). CONCLUSIONS: Male patients with high serum LDH on admission are those who undergo more often an intensification of care among COVID-19 inpatients. Both age and respiratory performances on admission modify the prognosis within the hospitalization period. [ABSTRACT FROM AUTHOR]

Published
2022

36. Micro-Fragmented Adipose Tissue: A New Minimally Invasive Method for Treatment of Anal Fistula? A Pilot Study

Author

Ascanelli S, Carcoforo P, Anania G, Cavallesco G, Nicolò Fabbri, D’Urbano F, Resta G, and Ferrocci G

Subjects
Anal fistula, medicine.medical_specialty, Fistula, Adipose Tissue, Anal Canal, Fistula, Lipogems, business.industry, Anal Canal, Adipose tissue, Anal canal, medicine.disease, Lipogems, NO, Surgery, medicine.anatomical_structure, Adipose Tissue, Medicine, business, LS7_4
Published
2019
Full Text
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37. Right on track?

Author

Hofman, Maarten P. G., Hayward, M. W., Heim, M., Marchand, P., Rolandsen, C. M., Mattisson, Jenny, Urbano, F., Heurich, M., Mysterud, A., Melzheimer, J., Morellet, N., Voigt, Ulrich, Allen, B. L., Gehr, Benedikt, Rouco Zufiaurre, Carlos, Ullmann, Wiebke (Dr.), Holand, O., Jorgensen, n H., Steinheim, G., Cagnacci, F., Kroeschel, M., Kaczensky, P., Buuveibaatar, B., Payne, J. C., Palmegiani, I, Jerina, K., Kjellander, P., Johansson, O., LaPoint, S., Bayrakcismith, R., Linnell, J. D. C., Zaccaroni, M., Jorge, M. L. S., Oshima, J. E. F., Songhurst, A., Fischer, C., Mc Bride, R. T., Thompson, J. J., Streif, S., Sandfort, R., Bonenfant, Christophe, Drouilly, M., Klapproth, M., Zinner, Dietmar, Yarnell, Richard, Stronza, A., Wilmott, L., Meisingset, E., Thaker, Maria, Vanak, A. T., Nicoloso, S., Graeber, R., Said, S., Boudreau, M. R., Devlin, A., Hoogesteijn, R., May-Junior, J. A., Nifong, J. C., Odden, J., Quigley, H. B., Tortato, F., Parker, D. M., Caso, A., Perrine, J., Tellaeche, C., Zieba, F., Zwijacz-Kozica, T., Appel, C. L., Axsom, I, Bean, W. T., Cristescu, B., Periquet, S., Teichman, K. J., Karpanty, S., Licoppe, A., Menges, V, Black, K., Scheppers, Thomas L., Schai-Braun, S. C., Azevedo, F. C., Lemos, F. G., Payne, A., Swanepoel, L. H., Weckworth, B., Berger, A., Bertassoni, Alessandra, McCulloch, G., Sustr, P., Athreya, V, Bockmuhl, D., Casaer, J., Ekori, A., Melovski, D., Richard-Hansen, C., van de Vyver, D., Reyna-Hurtado, R., Robardet, E., Selva, N., Sergiel, A., Farhadinia, M. S., Sunde, P., Portas, R., Ambarli, Hüseyin, Berzins, R., Kappeler, P. M., Mann, G. K., Pyritz, L., Bissett, C., Grant, T., Steinmetz, R., Swedell, Larissa, Welch, R. J., Armenteras, D., Bidder, O. R., Gonzalez, T. M., Rosenblatt, A., Kachel, S., and Balkenhol, N.

Subjects
ddc:590, Institut für Biochemie und Biologie
Abstract

Satellite telemetry is an increasingly utilized technology in wildlife research, and current devices can track individual animal movements at unprecedented spatial and temporal resolutions. However, as we enter the golden age of satellite telemetry, we need an in-depth understanding of the main technological, species-specific and environmental factors that determine the success and failure of satellite tracking devices across species and habitats. Here, we assess the relative influence of such factors on the ability of satellite telemetry units to provide the expected amount and quality of data by analyzing data from over 3,000 devices deployed on 62 terrestrial species in 167 projects worldwide. We evaluate the success rate in obtaining GPS fixes as well as in transferring these fixes to the user and we evaluate failure rates. Average fix success and data transfer rates were high and were generally better predicted by species and unit characteristics, while environmental characteristics influenced the variability of performance. However, 48% of the unit deployments ended prematurely, half of them due to technical failure. Nonetheless, this study shows that the performance of satellite telemetry applications has shown improvements over time, and based on our findings, we provide further recommendations for both users and manufacturers.

Published
2019

38. Right on track? Performance of satellite telemetry in terrestrial wildlife research

Author

Hayward, M.W., Heim, M., Marchand, P., Rolandsen, C.M., Mattisson, J., Urbano, F., Heurich, M., Mysterud, A., Melzheimer, J., Morellet, Nicolas, Voigt, U., Allen, B.L., Gehr, B., Rouco, C., Ullmann, W., Holand, O., Jorgensen, N.H., Steinheim, G., Cagnacci, F., Kroeschel, M., Kaczensky, P., Buuveibaatar, B., Payne, J.C., Palmegiani, I., Jerina, K., Kjellander, P., Johansson, O., LaPoint, S., Bayrakcismith, R., Linnell, J.D.C., Zaccaroni, M., Jorge, M.L.S., Oshima, J.E.F., Songhurst, A., Fischer, C., Mc Bride, R.T., Thompson, J.J., Streif, S., Sandfort, R., Bonenfant, C., Drouilly, M., Klapproth, M., Zinner, D., Yarnell, R., Stronza, A., Wilmott, L., Meisingset, E., Thaker, M., Vanak, A.T., Nicoloso, S., Graeber, R., Said, S., Boudreau, M.R., Devlin, A., Hoogesteijn, R., May-Junior, J.A., Nifong, J.C., Odden, J., Quigley, H.B., Tortato, F., Parker, D.M., Caso, A., Perrine, J., Tellaeche, C., Zieba, F., Zwijacz-Kozica, T., Appel, C. L., Axsom, I., Bean, W.T., Cristescu, B., Periquet, S., Teichman, K.J., Karpanty, S., Licoppe, A., Menges, V., Black, K., Scheppers, T.L., Schai-Braun, S.C., Azevedo, F.C., Lemos, F.G., Payne, A., Swanepoel, L.H., Weckworth, B., Berger, A., Bertassoni, A., McCulloch, G., Sustr, P., Athreya, V., Bockmuhl, D., Casaer, J., Ekori, A., Melovski, D., Richard-Hansen, C., van de Vyver, D., Reyna-Hurtado, R., Robardet, E., Selva, N., Sergiel, A., Farhadinia, M. S., Sunde, P., Portas, R., Ambarli, H., Berzins, R., Kappeler, P.M., Mann, G.K., Pyritz, L., Bissett, C., Grant, T., Steinmetz, R., Swedell, L., Welch, R.J., Armenteras, D., Bidder, O.R., Gonzalez, T.M., Rosenblatt, A., Kachel, S., Balkenhol, N., and Hofman, M.P.G.

Subjects
GLOBAL POSITIONING SYSTEM, GPS-TELEMETRY, COLLAR PERFORMANCE, FIX SUCCESS, R PACKAGE, HABITAT, BEHAVIOR, SELECTION, LOCATION, PATTERNS
Abstract

Satellite telemetry is an increasingly utilized technology in wildlife research, and current devices can track individual animal movements at unprecedented spatial and temporal resolutions. However, as we enter the golden age of satellite telemetry, we need an in-depth understanding of the main technological, species-specific and environmental factors that determine the success and failure of satellite tracking devices across species and habitats. Here, we assess the relative influence of such factors on the ability of satellite telemetry units to provide the expected amount and quality of data by analyzing data from over 3,000 devices deployed on 62 terrestrial species in 167 projects worldwide. We evaluate the success rate in obtaining GPS fixes as well as in transferring these fixes to the user and we evaluate failure rates. Average fix success and data transfer rates were high and were generally better predicted by species and unit characteristics, while environmental characteristics influenced the variability of performance. However, 48% of the unit deployments ended prematurely, half of them due to technical failure. Nonetheless, this study shows that the performance of satellite telemetry applications has shown improvements over time, and based on our findings, we provide further recommendations for both users and manufacturers.

Published
2019

39. Right on track? Performance of satellite telemetry in terrestrial wildlife research

Author

Hofman, MPG, Hayward, MW, Heim, M, Marchand, P, Rolandsen, CM, Mattisson, J, Urbano, F, Heurich, M, Mysterud, A, Melzheimer, J, Morellet, N, Voigt, U, Allen, BL, Gehr, B, Rouco, C, Ullmann, W, Holand, Ø, Jørgensen, NH, Steinheim, G, Cagnacci, F, Kroeschel, M, Kaczensky, P, Buuveibaatar, B, Payne, JC, Palmegiani, I, Jerina, K, Kjellander, P, Johansson, Ö, Lapoint, S, Bayrakcismith, R, Linnell, JDC, Zaccaroni, M, Jorge, MLS, Oshima, JEF, Songhurst, A, Fischer, C, Bride, RT, Thompson, JJ, Streif, S, Sandfort, R, Bonenfant, C, Drouilly, M, Klapproth, M, Zinner, D, Yarnell, R, Stronza, A, Wilmott, L, Meisingset, E, Thaker, M, Vanak, AT, Nicoloso, S, Graeber, R, Said, S, Boudreau, MR, Devlin, A, Hoogesteijn, R, May-Junior, JA, Nifong, JC, Odden, J, Quigley, HB, Tortato, F, Parker, DM, Caso, A, Perrine, J, Tellaeche, C, Zieba, F, Zwijacz-Kozica, T, Appel, CL, Axsom, I, Bean, WT, Cristescu, B, Périquet, S, Teichman, KJ, Karpanty, S, Licoppe, A, Menges, V, Black, K, Scheppers, TL, Schai-Braun, SC, Azevedo, FC, Lemos, FG, Payne, A, Swanepoel, LH, Weckworth, BV, Berger, A, Bertassoni, A, McCulloch, G, Šustr, P, Athreya, V, Bockmuhl, D, Casaer, J, Ekori, A, Melovski, D, Richard-Hansen, C, Van De Vyver, D, Reyna-Hurtado, R, Robardet, E, Selva, N, Sergiel, A, Farhadinia, MS, Sunde, P, Portas, R, Ambarli, H, Berzins, R, Kappeler, PM, Mann, GK, Pyritz, L, Bissett, C, Grant, T, Steinmetz, R, Swedell, L, Welch, RJ, Armenteras, D, Bidder, OR, González, TM, Rosenblatt, A, Kachel, S, Balkenhol, N, University of Goettingen, Bangor University, Nelson Mandela University, Norwegian Institute for Nature Research, Unité Ongulés Sauvages, Université Grenoble Alpes, University of Freiburg, Bavarian Forest National Park, University of Oslo, Leibniz Institute for Zoo and Wildlife Research, INRA, University of Veterinary Medicine, Institute for Agriculture and the Environment, University of Zurich, Centre National de la Recherche Scientifique (CNRS), Landcare Research, Universidad de Córdoba, University of Potsdam, Leibniz Centre for Agricultural Landscape Research (ZALF), Norwegian University of Life Sciences, Fondazione Edmund Mach, Forest Research Institute of Baden-Wuerttemberg, Mongolia Program, Biotechnical Faculty, Swedish University for Agricultural Sciences (SLU), Snow Leopard Trust, Max-Planck Institute for Ornithology, Columbia University, Panthera, University of Florence, Vanderbilt University, Universidade Estadual Paulista (Unesp), Ecoexist, University of Oxford, Texas A and M University, D’Ingenierie et d’Architecture de Geneve, Faro Maro Ecoresearch, Guyra Paraguay—CONACYT, Instituto Saite, Ronin Institute, University of Natural Resources and Applied Life Sciences, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, University of Cape Town, Leibniz Institute for Primate Research, Brackenhurst Campus, Office of Environment and Heritage, Norwegian Institute of Bioeconomy Research, Indian Institute of Science, Ashoka Trust for Research in Ecology and the Environment, DBT India Alliance, University of KwaZulu-Natal, D.R.E.Am. Italia, Unités Ongulés Sauvages, Trent University, SUNY College of Environmental Science and Forestry, University of Santa Catarina, Onçafari, Environmental Laboratory, Rhodes University, University of Mpumalanga, Ministery of Environment and Natural Resources of Mexico, Alianza Nacional Para la Conservacion del Jaguar A.C., California Polytechnic State University, Universidad Nacional de Jujuy–CONICET, Tatra National Park, Humboldt State University, South Africa, Main Camp Research, University of British Columbia, Virginia Tech., Service Public de Wallonie, Research Institute for Nature and Forest, Universidade Federal de Goiás (UFG), Fazenda Limoeiro, University of Venda, Instituto de Pesquisa e Conservação de Tamanduás no Brasil, Global Change Research Institute CAS, Wildlife Conservation Society—India, University of Applied Sciences and Arts of Western Switzerland, Macedonian Ecological Society, Office National de la Chasse et de la Faune Sauvage, Université de Guyane), El Colegio de la Frontera Sur, ANSES Nancy Laboratory for Rabies and Wildlife, Polish Academy of Sciences, Aarhus University, Duzce University, WWF Thailand, City University of New York, Universidad Nacional de Colombia, University of California, University of North Florida, University of Washington, University of Newcastle, Black Rock Forest, Sequoia Riverlands Trust, Ongava Research Centre, Scientific Services, Karlsruher Institut für Technologie (KIT), CEntre Technique des Industries Mécaniques (CETIM), CEntre Technique des Industries Mécaniques - Cetim (FRANCE), Department of Research and Documentation, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Deutscher Wetterdienst [Offenbach] (DWD), Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft, Department of Animal and Man Biology, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Université de Lyon, Office Nationale de la Chasse et de la Faune Sauvage, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centro de Engenharia Biologica e Quimica, Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), SOPTOM, CRCC Centre for Research and Conservation of Chelonians, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Leibniz-Institut für Astrophysik Potsdam (AIP), Life Cycle Strategies, Georg-August-University [Göttingen], Università degli Studi di Firenze = University of Florence (UniFI), Laboratoire Chrono-environnement (UMR 6249) (LCE), Georg-August-University = Georg-August-Universität Göttingen, and Fish and Wildlife Conservation

Subjects
Questionnaires, SELECTION, Forests, Wildlife, Data acquisition, Temperate forests, Animal performance, Data reduction, Global positioning system, Movement ecology, Telemetry, R PACKAGE, Spacecraft, HABITAT, Animal Management, Centre for Ecological Sciences, Ecology, Eukaryota, Agriculture, Terrestrial Environments, Navigation, GPS-TELEMETRY, Multidisciplinary Sciences, Data Acquisition, Research Design, Engineering and Technology, Science & Technology - Other Topics, Medicine, Temperate Forests, Information Technology, BEHAVIOR, Research Article, Environmental Monitoring, Computer and Information Sciences, Animals, Animals, Wild, Ecosystem, Geographic Information Systems, Animal Types, Science, GPS telemetry, Research and Analysis Methods, Ecosystems, COLLAR PERFORMANCE, FIX SUCCESS, Settore BIO/07 - ECOLOGIA, LOCATION, Animal Performance, GLOBAL POSITIONING SYSTEM, Survey Research, Science & Technology, Bio-logging, Ecology and Environmental Sciences, Organisms, Biology and Life Sciences, Data Reduction, Wildlife conservation, PATTERNS, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Zoology
Abstract

Satellite telemetry is an increasingly utilized technology in wildlife research, and current devices can track individual animal movements at unprecedented spatial and temporal resolutions. However, as we enter the golden age of satellite telemetry, we need an in-depth understanding of the main technological, species-specific and environmental factors that determine the success and failure of satellite tracking devices across species and habitats. Here, we assess the relative influence of such factors on the ability of satellite telemetry units to provide the expected amount and quality of data by analyzing data from over 3,000 devices deployed on 62 terrestrial species in 167 projects worldwide. We evaluate the success rate in obtaining GPS fixes as well as in transferring these fixes to the user and we evaluate failure rates. Average fix success and data transfer rates were high and were generally better predicted by species and unit characteristics, while environmental characteristics influenced the variability of performance. However, 48% of the unit deployments ended prematurely, half of them due to technical failure. Nonetheless, this study shows that the performance of satellite telemetry applications has shown improvements over time, and based on our findings, we provide further recommendations for both users and manufacturers. Forest and Nature for Society (FONASO) Erasmus Mundus Joint Doctorate programme [2013-09] University of Goettingen Norwegian Environment Agency Research Council of Norway [212919] Norwegian Institute for Nature Research Messerli Foundation, WWF Landcare Research Ltd New Zealand TBfree New Zealand (AHB project) [R10737] Norwegian Research Counsil, Smafefondet, NMBU Research Council of Norway Federal State of Baden-Wuerttemberg (Landesjagdabgabe) Wildlife Conservation Society Swedish Environmental Protection Agency private foundation "Marie Clair Cronstedts stiftelse" NASA Arctic Boreal Vulnerability Experiment [NNX15AV92A] National Geographic Society Waitt Grant Program [W157-110] FAPESP [2013/50421-2, 2014/23132-2] CNPq [312045/2013-1, 312292/2016-3, 161089/2014-3] Silicon Valley Community Foundation The Overbrook Foundation International ReSource Award WCS Brasil Vanderbilt University PROCAD/CAPES [88881.068425/2014-01] MLSJ Fundacao de Amparo a Pesquisa do Estado de Sao Paulo Fapesp [2013/50421-2, 2014/23132-2] Projeto Pecarideos - WCS Brasil Howard G Buffett Foundation Consejo Nacional de Ciencia y Tecnologia -CONACYT Austrian Research Promotion Agency (FFG) [814274, 834118] Leobner Realgemeinschaft Forstbetrieb Kletschach WWF Nedbank Green Trust [GT 2251] DFG [Fi707/9-1/DFG Zi548/6-1/DAAD (D/12/41834), FI707/9-1, ZI548/6-1] DAAD [D/12/41834] Nottingham Trent University The Howard G. Buffett Foundation ISRO-IISc Space Technology Cell Wellcome Trust/DBT India Alliance and Space Technology Cell, Indian Institute of Science Lower Saxony Ministry of Food, Agriculture and Consumer Protection Panthera Kaplan Graduate Award Bank of America Reindeer Development Fund in Norway Rhodes University Robin Hurt Wildlife Foundation Caesar Kleberg Wildlife Research Institute Wildlife Conservation Network Humboldt State University HSU Marine and Coastal Science Initiative Humboldt State University Research, Scholarship and Creative Activities Grant Claude Leon Foundation Postdoctoral Fellowship The Cape Leopard Trust Conservation South Africa South African National Parks HERD project (Hwange Environmental Research Development) - Agence Nationale de la Recherche (FEAR project) [ANR-08-BLAN-0022] Centre National de la Recherche Scientifique (Programme Zones Ateliers) National Geographic Society [C151-08] NSERC CGS D U.S. Fish and Wildlife Service Service public de Wallonie Direction generale de l'Agriculture, des Ressources naturelles et de l'Environnement U.S. Army Corps of Engineers Parrotia-Stiftung Stiftung Dr. Joachim de Giacomi Basler Stiftung fur biologische Forschung Messerli Stiftung Carl Burger Stiftung CIC Schweiz CIC Deutschland Paul Schiller Stiftung Karl Mayer Stiftung Consorcio Capim Branco de Energia Ministere de l'Agriculture de l'Agroalimentaire et de la Foret Conseil Regional de Bourgogne Conseil General de la Cote d'Or Federation Departementale des Chasseurs de Cote d'Or Groupement de Defense Sanitaire de Cote d'Or Federation Nationale des Chasseurs Office National de la Chasse et de la Faune Sauvage South African National Research Foundation [107099] Sao Paulo Research Foundation [FAPESP 2013/04957-8, FAPESP 2013/18526-9] MAVA Foundation, Switzerland The Deutsche Bundesstiftung Umwelt DBU (German Federal Environmental Foundation) Centre National d'Etudes Spatiales (CNES) Project GLOBE - Polish-Norwegian Research Programme [POLNOR/198352/85/2013] ASer: Norway Grants under the Polish-Norwegian Research Program [POL-NOR/198352/85/2013] The People's Trust for Endangered Species (PTES) Zoologische Gesellschaft fur Arten-und Populationsschutz (ZGAP) Iranian Cheetah Society Quagga Conservation Fund IdeaWild Association Francaise des Parcs Zoologiques (AFdPZ) DEAL (Direction de l'Environnement de l'Amenagement et du Logement) de Guyane CNES (Centre National d'Etudes Spatiales) The Nedbank WWF Green Trust The International Foundation for Science Cape Leopard Trust German Research Foundation [DFG: KA 1082/16-1] The Wildlife and Reserve Management Research Group (WRMRG) International Foundation for Science (IFS) Safari Club International Foundation (SCIF) The Rufford Small Grants Foundation Ernst & Ethel Eriksen Trust WWF Sweden Leakey Foundation National Geographic Society WennerGren Foundation Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias, Project "Efecto de la presencia de saladosnaturales en la distribucion y uso de habitat de la danta de tier-ras bajas (Tapirus terrestris) en las amazonas colombiano" [1101569-33286, 0385-2013] Alexander von Humboldt Foundation NSF Graduate Research Fellowship [DEG-125608] Sustainability East Asia LLC - SEA Amarula Trust National Geographic Earthwatch Institute World Wildlife Fund for Nature Columbus Zoo California North Coast Chapter of The Wildlife Society Sequoia Park Zoo Foundation Anses This work was supported by: Forest and Nature for Society (FONASO) Erasmus Mundus Joint Doctorate programme (CONTRACT NO. 2013-09) to MPGH, Publication costs were covered by the Open Access Publication Fund of the University of Goettingen; The Norwegian Environment Agency, the Research Council of Norway (project 212919), Norwegian Institute for Nature Research to JM; Messerli Foundation, WWF to JMel; CRou: The author was supported in the form of salary by a postdoctoral grant funded by Landcare Research Ltd New Zealand and data provided was funded by research project grant from TBfree New Zealand (AHB project number R10737). Norwegian Research Counsil, Smafefondet, NMBU to NHJ; The Research Council of Norway to GS; Federal State of Baden-Wuerttemberg (Landesjagdabgabe) to MK; Funding for the capture and collaring of khulan was received from Wildlife Conservation Society, administered through a cooperative agreement with Sustainability East Asia LLC - SEA and originating from Oy Du Tolgoi -OT gold and copper mining company to PK; Swedish fieldwork was supported by the Swedish Environmental Protection Agency and by the private foundation "Marie Clair Cronstedts stiftelse" to PKje; NASA Arctic Boreal Vulnerability Experiment (project #NNX15AV92A), National Geographic Society Waitt Grant Program (Grant #W157-110) to SL; Research Council of Norway to JDCL; FAPESP (2013/50421-2, 2014/23132-2), CNPq (312045/2013-1; 312292/2016-3; 161089/2014-3), Silicon Valley Community Foundation, The Overbrook Foundation, the International ReSource Award, WCS Brasil, and Vanderbilt University. PROCAD/CAPES (88881.068425/2014-01); MLSJ Fundacao de Amparo a Pesquisa do Estado de Sao Paulo Fapesp (process: 2013/50421-2 and scholarship: 2014/23132-2) and CNPQ (scholarship: 161089/2014-3), Projeto Pecarideos - WCS Brasil and Vanderbilt University for funding this research to JEFO.; Howard G Buffett Foundation, Amarula Trust to AS; Consejo Nacional de Ciencia y Tecnologia -CONACYT with resources from the FEE to JJT; Austrian Research Promotion Agency (FFG) grant numbers 814274 and 834118, Leobner Realgemeinschaft and Forstbetrieb Kletschach to RS; WWF Nedbank Green Trust (grant number GT 2251) to MD; DFG Fi707/9-1/DFG Zi548/6-1/DAAD (D/12/41834) to MKla; DFG FI707/9-1, DFG ZI548/6-1, DAAD D/12/41834 to DZ; GPS tags were funded by Nottingham Trent University, National Geographic, Earthwatch Institute, World Wildlife Fund for Nature, Columbus Zoo to RY; The Howard G. Buffett Foundation to AStr; ISRO-IISc Space Technology Cell to MT; Wellcome Trust/DBT India Alliance and Space Technology Cell, Indian Institute of Science to ATV; D.R.E. Am. Italia provided support in the form of salary for author SN, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific role of this author is articulated in the 'author contributions' section.; RG was supported by funds of the Lower Saxony Ministry of Food, Agriculture and Consumer Protection; Panthera Kaplan Graduate Award to AD; Bank of America to JAM; The Norwegian Environment Agency, the Research Council of Norway (Project 212919), the Reindeer Development Fund in Norway, and several County administrations around Norway to JO; Rhodes University to DMP; Robin Hurt Wildlife Foundation, Caesar Kleberg Wildlife Research Institute to AC; Wildlife Conservation Network, Panthera to CT; Humboldt State University, HSU Marine and Coastal Science Initiative, California North Coast Chapter of The Wildlife Society, Sequoia Park Zoo Foundation to CLA; Humboldt State University Research, Scholarship and Creative Activities Grant to IA; Humboldt State University Research, Scholarship and Creative Activities Grant to WTB; Claude Leon Foundation Postdoctoral Fellowship, The Cape Leopard Trust, Conservation South Africa, South African National Parks to BC; GPS collars were funded by the HERD project (Hwange Environmental Research Development), funded by the Agence Nationale de la Recherche (FEAR project ANR-08-BLAN-0022), and the Centre National de la Recherche Scientifique (Programme Zones Ateliers). Some collars were funded by the National Geographic Society GRANT #C151-08 to SP; NSERC CGS D to KJT; SK: U.S. Fish and Wildlife Service to SK; Service public de Wallonie. Direction generale de l'Agriculture, des Ressources naturelles et de l'Environnement to AL; U.S. Army Corps of Engineers, U.S. Fish and Wildlife Service to KB; Parrotia-Stiftung, Stiftung Dr. Joachim de Giacomi, Basler Stiftung fur biologische Forschung, Messerli Stiftung, Carl Burger Stiftung, CIC Schweiz, CIC Deutschland, Paul Schiller Stiftung and Karl Mayer Stiftung to SCS; Consorcio Capim Branco de Energia to FCA; Consorcio Capim Branco de Energia to FGL; Ministere de l'Agriculture de l'Agroalimentaire et de la Foret, the Conseil Regional de Bourgogne, the Conseil General de la Cote d'Or, the Federation Departementale des Chasseurs de Cote d'Or, the Groupement de Defense Sanitaire de Cote d'Or, the Federation Nationale des Chasseurs and the Office National de la Chasse et de la Faune Sauvage to AP.; ; South African National Research Foundation (Grant number: 107099) to LHS; Sao Paulo Research Foundation (FAPESP 2013/04957-8 and FAPESP 2013/18526-9) to ABer; MAVA Foundation, Switzerland; The Deutsche Bundesstiftung Umwelt DBU (German Federal Environmental Foundation) to DM; Centre National d'Etudes Spatiales (CNES) to CRic; Anses to ER; Project GLOBE (POLNOR/198352/85/2013) funded by the Polish-Norwegian Research Programme operated by the National Centre for Research and Development; ASer: Norway Grants under the Polish-Norwegian Research Program operated by the National Centre for Research and Development (GLOBE, POL-NOR/198352/85/2013) to NS; The People's Trust for Endangered Species (PTES), Zoologische Gesellschaft fur Arten-und Populationsschutz (ZGAP), Iranian Cheetah Society, Quagga Conservation Fund, IdeaWild, Panthera and Association Francaise des Parcs Zoologiques (AFdPZ) to MSF; DEAL (Direction de l'Environnement de l'Amenagement et du Logement) de Guyane, CNES (Centre National d'Etudes Spatiales) to RBer; The Nedbank WWF Green Trust, The International Foundation for Science, the Cape Leopard Trust, Rhodes University to GKM; German Research Foundation (DFG: KA 1082/16-1) to LP; The Wildlife and Reserve Management Research Group (WRMRG), International Foundation for Science (IFS), Safari Club International Foundation (SCIF), The Rufford Small Grants Foundation, Ernst & Ethel Eriksen Trust to TG; WWF Sweden to RSte; Leakey Foundation, National Geographic Society, WennerGren Foundation to LS; Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias, Project "Efecto de la presencia de saladosnaturales en la distribucion y uso de habitat de la danta de tier-ras bajas (Tapirus terrestris) en las amazonas colombiano" (grantnumber 1101569-33286, contract: 0385-2013) to DA; PostDoctoral Fellowship from the Alexander von Humboldt Foundation to ORB; NSF Graduate Research Fellowship DEG-125608 to SKac. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; We thank Horst Reinecke and Christian Trothe for database management and data entry, and James Gibbons, Matthias Schmid and Benjamin Hofner for their enlightening explanations on the statistics. We thank Stan Tomkiewicz for insightful discussion on GPS collar functioning, and the Eurodeer. org network, Sarah Davidson of Movebank. org, and Stephanie O'Donnell of WILDLABS. NET for helping to spread the word about this study. We also thank Jonah Gula, Olav Strand, Ole Roer, Liu Yanlin, Bernt-Erik Saether, Anders Borstad, Laura McMahon, Thomas Morrison, Maurizio Ramanzin, Vebjorn Veiberg, Erling Johan Solberg, Leif Soennichsen, Hans Christian Pedersen, Tom McCarthy, Jacqueline L. Frair, Siobhan Dyer, Morten Odden, Lars Haugaard, and Peter G. Crawshaw, Jr. for their data contributions. The publication was supported by the Open Access Publication Fund of the University of Goettingen.

Published
2019
Full Text
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43. Right on track? Performance of satellite telemetry in terrestrial wildlife research

Author

Hofman, M. P. G., Hayward, M. W., Heim, M., Marchand, P., Rolandsen, C. M., Mattisson, J., Urbano, F., Heurich, M., Mysterud, A., Melzheimer, J., Morellet, N., Voigt, U., Allen, B. L., Gehr, B., Rouco, C., Ullmann, W., Holand, O., Jorgensen, n H., Steinheim, G., Cagnacci, F., Kroeschel, M., Kaczensky, P., Buuveibaatar, B., Payne, J. C., Palmegiani, I., Jerina, K., Kjellander, P., Johansson, O., LaPoint, S., Bayrakcismith, R., Linnell, J. D. C., Zaccaroni, M., Jorge, M. L. S., Oshima, J. E. F., Songhurst, A., Fischer, C., McBride, R. T. Jr., Thompson, J. J., Streif, S., Sandfort, R., Bonenfant, C., Drouilly, M., Klapproth, M., Zinner, D., Yarnell, R., Stronza, A., Wilmott, L., Meisingset, E., Thaker, M., Vanak, A. T., Nicoloso, S., Graeber, R., Said, S., Boudreau, M. R., Devlin, A., Hoogesteijn, R., May-Junior, J. A., Nifong, J. C., Odden, J., Quigley, Howard B., Tortato, F., Parker, D. M., Caso, A., Perrine, J., Tellaeche, C., Zieba, F., Zwijacz-Kozica, T., Appel, C. L., Axsom, I., Bean, W. T., Cristescu, B., Periquet, S., Teichman, K. J., Karpanty, Sarah M., Licoppe, A., Menges, V., Black, K., Scheppers, T. L., Schai-Braun, S. C., Azevedo, F. C., Lemos, F. G., Payne, A., Swanepoel, L. H., Weckworth, B., V., Berger, A., Bertassoni, A., McCulloch, G., Sustr, P., Athreya, V., Bockmuhl, D., Casaer, J., Ekori, A., Melovski, D., Richard-Hansen, C., van de Vyver, D., Reyna-Hurtado, R., Robardet, E., Selva, N., Sergiel, A., Farhadinia, Mohammad S., Sunde, P., Portas, R., Ambarli, H., Berzins, R., Kappeler, P. M., Mann, G. K., Pyritz, L., Bissett, C., Grant, T., Steinmetz, R., Swedell, L., Welch, R. J., Armenteras, D., Bidder, O. R., Gonzalez, T. M., Rosenblatt, A., Kachel, S., Balkenhol, N., Hofman, M. P. G., Hayward, M. W., Heim, M., Marchand, P., Rolandsen, C. M., Mattisson, J., Urbano, F., Heurich, M., Mysterud, A., Melzheimer, J., Morellet, N., Voigt, U., Allen, B. L., Gehr, B., Rouco, C., Ullmann, W., Holand, O., Jorgensen, n H., Steinheim, G., Cagnacci, F., Kroeschel, M., Kaczensky, P., Buuveibaatar, B., Payne, J. C., Palmegiani, I., Jerina, K., Kjellander, P., Johansson, O., LaPoint, S., Bayrakcismith, R., Linnell, J. D. C., Zaccaroni, M., Jorge, M. L. S., Oshima, J. E. F., Songhurst, A., Fischer, C., McBride, R. T. Jr., Thompson, J. J., Streif, S., Sandfort, R., Bonenfant, C., Drouilly, M., Klapproth, M., Zinner, D., Yarnell, R., Stronza, A., Wilmott, L., Meisingset, E., Thaker, M., Vanak, A. T., Nicoloso, S., Graeber, R., Said, S., Boudreau, M. R., Devlin, A., Hoogesteijn, R., May-Junior, J. A., Nifong, J. C., Odden, J., Quigley, Howard B., Tortato, F., Parker, D. M., Caso, A., Perrine, J., Tellaeche, C., Zieba, F., Zwijacz-Kozica, T., Appel, C. L., Axsom, I., Bean, W. T., Cristescu, B., Periquet, S., Teichman, K. J., Karpanty, Sarah M., Licoppe, A., Menges, V., Black, K., Scheppers, T. L., Schai-Braun, S. C., Azevedo, F. C., Lemos, F. G., Payne, A., Swanepoel, L. H., Weckworth, B., V., Berger, A., Bertassoni, A., McCulloch, G., Sustr, P., Athreya, V., Bockmuhl, D., Casaer, J., Ekori, A., Melovski, D., Richard-Hansen, C., van de Vyver, D., Reyna-Hurtado, R., Robardet, E., Selva, N., Sergiel, A., Farhadinia, Mohammad S., Sunde, P., Portas, R., Ambarli, H., Berzins, R., Kappeler, P. M., Mann, G. K., Pyritz, L., Bissett, C., Grant, T., Steinmetz, R., Swedell, L., Welch, R. J., Armenteras, D., Bidder, O. R., Gonzalez, T. M., Rosenblatt, A., Kachel, S., and Balkenhol, N.

Abstract

Satellite telemetry is an increasingly utilized technology in wildlife research, and current devices can track individual animal movements at unprecedented spatial and temporal resolutions. However, as we enter the golden age of satellite telemetry, we need an in-depth understanding of the main technological, species-specific and environmental factors that determine the success and failure of satellite tracking devices across species and habitats. Here, we assess the relative influence of such factors on the ability of satellite telemetry units to provide the expected amount and quality of data by analyzing data from over 3,000 devices deployed on 62 terrestrial species in 167 projects worldwide. We evaluate the success rate in obtaining GPS fixes as well as in transferring these fixes to the user and we evaluate failure rates. Average fix success and data transfer rates were high and were generally better predicted by species and unit characteristics, while environmental characteristics influenced the variability of performance. However, 48% of the unit deployments ended prematurely, half of them due to technical failure. Nonetheless, this study shows that the performance of satellite telemetry applications has shown improvements over time, and based on our findings, we provide further recommendations for both users and manufacturers.

Published
2019
Full Text
View/download PDF

44. Right on track? Performance of satellite telemetry in terrestrial wildlife research

Author

Fish and Wildlife Conservation, Hofman, M. P. G., Hayward, M. W., Heim, M., Marchand, P., Rolandsen, C. M., Mattisson, J., Urbano, F., Heurich, M., Mysterud, A., Melzheimer, J., Morellet, N., Voigt, U., Allen, B. L., Gehr, B., Rouco, C., Ullmann, W., Holand, O., Jorgensen, n H., Steinheim, G., Cagnacci, F., Kroeschel, M., Kaczensky, P., Buuveibaatar, B., Payne, J. C., Palmegiani, I., Jerina, K., Kjellander, P., Johansson, O., LaPoint, S., Bayrakcismith, R., Linnell, J. D. C., Zaccaroni, M., Jorge, M. L. S., Oshima, J. E. F., Songhurst, A., Fischer, C., McBride, R. T. Jr., Thompson, J. J., Streif, S., Sandfort, R., Bonenfant, C., Drouilly, M., Klapproth, M., Zinner, D., Yarnell, R., Stronza, A., Wilmott, L., Meisingset, E., Thaker, M., Vanak, A. T., Nicoloso, S., Graeber, R., Said, S., Boudreau, M. R., Devlin, A., Hoogesteijn, R., May-Junior, J. A., Nifong, J. C., Odden, J., Quigley, Howard B., Tortato, F., Parker, D. M., Caso, A., Perrine, J., Tellaeche, C., Zieba, F., Zwijacz-Kozica, T., Appel, C. L., Axsom, I., Bean, W. T., Cristescu, B., Periquet, S., Teichman, K. J., Karpanty, Sarah M., Licoppe, A., Menges, V., Black, K., Scheppers, T. L., Schai-Braun, S. C., Azevedo, F. C., Lemos, F. G., Payne, A., Swanepoel, L. H., Weckworth, B., V., Berger, A., Bertassoni, A., McCulloch, G., Sustr, P., Athreya, V., Bockmuhl, D., Casaer, J., Ekori, A., Melovski, D., Richard-Hansen, C., van de Vyver, D., Reyna-Hurtado, R., Robardet, E., Selva, N., Sergiel, A., Farhadinia, Mohammad S., Sunde, P., Portas, R., Ambarli, H., Berzins, R., Kappeler, P. M., Mann, G. K., Pyritz, L., Bissett, C., Grant, T., Steinmetz, R., Swedell, L., Welch, R. J., Armenteras, D., Bidder, O. R., Gonzalez, T. M., Rosenblatt, A., Kachel, S., Balkenhol, N., Fish and Wildlife Conservation, Hofman, M. P. G., Hayward, M. W., Heim, M., Marchand, P., Rolandsen, C. M., Mattisson, J., Urbano, F., Heurich, M., Mysterud, A., Melzheimer, J., Morellet, N., Voigt, U., Allen, B. L., Gehr, B., Rouco, C., Ullmann, W., Holand, O., Jorgensen, n H., Steinheim, G., Cagnacci, F., Kroeschel, M., Kaczensky, P., Buuveibaatar, B., Payne, J. C., Palmegiani, I., Jerina, K., Kjellander, P., Johansson, O., LaPoint, S., Bayrakcismith, R., Linnell, J. D. C., Zaccaroni, M., Jorge, M. L. S., Oshima, J. E. F., Songhurst, A., Fischer, C., McBride, R. T. Jr., Thompson, J. J., Streif, S., Sandfort, R., Bonenfant, C., Drouilly, M., Klapproth, M., Zinner, D., Yarnell, R., Stronza, A., Wilmott, L., Meisingset, E., Thaker, M., Vanak, A. T., Nicoloso, S., Graeber, R., Said, S., Boudreau, M. R., Devlin, A., Hoogesteijn, R., May-Junior, J. A., Nifong, J. C., Odden, J., Quigley, Howard B., Tortato, F., Parker, D. M., Caso, A., Perrine, J., Tellaeche, C., Zieba, F., Zwijacz-Kozica, T., Appel, C. L., Axsom, I., Bean, W. T., Cristescu, B., Periquet, S., Teichman, K. J., Karpanty, Sarah M., Licoppe, A., Menges, V., Black, K., Scheppers, T. L., Schai-Braun, S. C., Azevedo, F. C., Lemos, F. G., Payne, A., Swanepoel, L. H., Weckworth, B., V., Berger, A., Bertassoni, A., McCulloch, G., Sustr, P., Athreya, V., Bockmuhl, D., Casaer, J., Ekori, A., Melovski, D., Richard-Hansen, C., van de Vyver, D., Reyna-Hurtado, R., Robardet, E., Selva, N., Sergiel, A., Farhadinia, Mohammad S., Sunde, P., Portas, R., Ambarli, H., Berzins, R., Kappeler, P. M., Mann, G. K., Pyritz, L., Bissett, C., Grant, T., Steinmetz, R., Swedell, L., Welch, R. J., Armenteras, D., Bidder, O. R., Gonzalez, T. M., Rosenblatt, A., Kachel, S., and Balkenhol, N.

Abstract

Satellite telemetry is an increasingly utilized technology in wildlife research, and current devices can track individual animal movements at unprecedented spatial and temporal resolutions. However, as we enter the golden age of satellite telemetry, we need an in-depth understanding of the main technological, species-specific and environmental factors that determine the success and failure of satellite tracking devices across species and habitats. Here, we assess the relative influence of such factors on the ability of satellite telemetry units to provide the expected amount and quality of data by analyzing data from over 3,000 devices deployed on 62 terrestrial species in 167 projects worldwide. We evaluate the success rate in obtaining GPS fixes as well as in transferring these fixes to the user and we evaluate failure rates. Average fix success and data transfer rates were high and were generally better predicted by species and unit characteristics, while environmental characteristics influenced the variability of performance. However, 48% of the unit deployments ended prematurely, half of them due to technical failure. Nonetheless, this study shows that the performance of satellite telemetry applications has shown improvements over time, and based on our findings, we provide further recommendations for both users and manufacturers.

Published
2019

45. Class 1, 2, and 3 BRAF-mutated metastatic colorectal cancer: A detailed clinical, pathologic, and molecular characterization

Author

Schirripa, M., Biason, P., Lonardi, S., Pella, N., Simona Pino, M., Urbano, F., Antoniotti, C., Cremolini, C., Corallo, S., Pietrantonio, F., Gelsomino, F., Cascinu, S., Orlandi, Armando, Munari, G., Malapelle, U., Saggio, S., Fontanini, Giovanni, Rugge, M., Mescoli, C., Lazzi, S., Bonetti, L. R., Lanza, Gaetano Antonio, Dei Tos, A. P., De Maglio, G., Martini, Maurizio, Bergamo, F., Zagonel, V., Loupakis, F., Fassan, M., Orlandi A. (ORCID:0000-0001-5253-4678), Fontanini G., Lanza G. (ORCID:0000-0003-2187-6653), Martini M. (ORCID:0000-0002-6260-6310), Schirripa, M., Biason, P., Lonardi, S., Pella, N., Simona Pino, M., Urbano, F., Antoniotti, C., Cremolini, C., Corallo, S., Pietrantonio, F., Gelsomino, F., Cascinu, S., Orlandi, Armando, Munari, G., Malapelle, U., Saggio, S., Fontanini, Giovanni, Rugge, M., Mescoli, C., Lazzi, S., Bonetti, L. R., Lanza, Gaetano Antonio, Dei Tos, A. P., De Maglio, G., Martini, Maurizio, Bergamo, F., Zagonel, V., Loupakis, F., Fassan, M., Orlandi A. (ORCID:0000-0001-5253-4678), Fontanini G., Lanza G. (ORCID:0000-0003-2187-6653), and Martini M. (ORCID:0000-0002-6260-6310)

Abstract

Purpose: BRAF mutations are grouped in activating RASindependent signaling as monomers (class 1-V600E) or as dimers (class 2-codons 597/601), and RAS-dependent with impaired kinase activity (class 3-codons 594/596). Although clinical, pathologic, and molecular features of V600EBRAFmutated metastatic colorectal cancer (mCRC) are well known, limited data are available from the two other classes. Experimental Design: Data from 117 patients with BRAF (92 class 1, 12 class 2, and 13 class 3)-mutated mCRC were collected. A total of 540 BRAF wt mCRCs were included as control. IHC profiling was performed to determine the consensus molecular subtypes (CMS), cytokeratin 7/20 profiles, tumor-infiltrating lymphocyte infiltration, and BM1/BM2 categorization. Overall survival (OS) and progression-free survival were evaluated by Kaplan-Meier and log-rank test. Results: Class 3 BRAF-mutated mCRC was more frequently left sided (P = 0.0028), pN0 (P = 0.0159), and without peritoneal metastases (P = 0.0176) compared with class 1, whereas class 2 cases were similar to class 1. Hazard ratio for OS, as compared with BRAF wt, was 2.38 [95% confidence interval (CI), 1.61-3.54] for class 1, 1.90 (95% CI, 0.85-4.26) for class 2, and 0.93 (95% CI, 0.51-1.69) for class 3 (P < 0.0001). Class 2 and 3 tumors were all assigned to CMS2-3. A higher median CD3/CD8-positive lymphocyte infiltration was observed in BRAF-mutated class 2 (P = 0.033) compared with class 3 cases. Conclusions: For the first time, different clinical and pathologic features and outcome data were reported according to the three BRAF mutation classes in mCRC. Specific targeted treatment strategies should be identified in the near future for such patients.

Published
2019

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