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2. Factors Associated With Decision to Treat or Not to Treat Helicobacter pylori Infection in Children: Data From the EuroPedHp Registry.

Author

Le Thi, Thu Giang, Werkstetter, Katharina, Kotilea, Kallirroi, Bontems, Patrick, Cabral, José, Cilleruelo, Maria Luz, Kori, Michal, Barrio, Josefa, Homan, Matjaž, Kalach, Nicolas, Lima, Rosa, Tavares, Marta, Urruzuno, Pedro, Misak, Zrinjka, Urbonas, Vaidotas, and Koletzko, Sibylle

Subjects
INFLAMMATORY bowel diseases, HELICOBACTER pylori infections, PEDIATRIC therapy, EOSINOPHILIC esophagitis, CHILD patients
Abstract

Background: European and North‐American guidelines on management of H. pylori infection in children provide the option not to treat even if the infection is endoscopically confirmed. We used data from the EuroPedHp Registry to identify factors associated with therapy decisions. Methods: We included treatment‐naïve patients reported between 2017 and 2020 from 30 centers in 17 European countries. Multivariable logistic regression identified factors including comorbidities within and outside the gastrointestinal (GI) tract influencing the decision for or against therapy. Results: Of 1165 patients (52% females, median age 12.8), 28% (321/1165) reported any alarm symptom, 26% (307/1165) comorbidities, and 16% (192/1165) did not receive eradication treatment. Therapy was initiated less often in children having any GI comorbidity (57%, n = 181), particularly in those with eosinophilic esophagitis (60%, n = 35), inflammatory bowel disease (54%, n = 28), and celiac disease (43%, n = 58), compared to those with non‐GI (86%, n = 126) or no comorbidity (89%, n = 858), despite similar frequencies of alarm and non‐alarm symptoms, ulcers, erosions, and nodular gastritis. Patients with GI and without comorbidities remained more likely untreated in high versus low H. pylori prevalence countries (p < 0.0001). In children without comorbidities, factors favoring therapy included older age, being overweight, having symptoms, erosions, antral nodularity, and available antibiotic susceptibility results. Conclusion: In this cohort, H. pylori‐infected children with GI comorbidities compared to no comorbidity showed 75% reduced chance of receiving eradication therapy. We found no evidence supporting different management strategies in infected patients with GI comorbidities compared to all pediatric patients with endoscopically proven H. pylori infection. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Extraintestinal Manifestations of Inflammatory Bowel Disease

Author

Rusoniene, Skirmante, Urbonas, Vaidotas, Avcin, Tadej, Emmi, Lorenzo, Series Editor, Prisco, Domenico, Series Editor, Salvarani, Carlo, Editorial Board Member, Sinico, Renato Alberto, Editorial Board Member, Meroni, Pier Luigi, Editorial Board Member, Roccatello, Dario, Editorial Board Member, Matucci-Cerinic, Marco, Editorial Board Member, Gattorno, Marco, Editorial Board Member, de Benedetti, Fabrizio, Editorial Board Member, Cimaz, Rolando, Editorial Board Member, Plebani, Alessandro, Editorial Board Member, Baldari, Cosima, Editorial Board Member, D'Elios, Mario Milco, Editorial Board Member, and Vaglio, Augusto, Editorial Board Member

Published
2020
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4. Genetic landscape of pediatric acute liver failure of indeterminate origin

Author

MDL patientenzorg, Lenz, Dominic, Schlieben, Lea D, Shimura, Masaru, Bianzano, Alyssa, Smirnov, Dmitrii, Kopajtich, Robert, Berutti, Riccardo, Adam, Rüdiger, Aldrian, Denise, Baric, Ivo, Baumann, Ulrich, Bozbulut, Neslihan Eksi, Brugger, Melanie, Brunet, Theresa, Bufler, Philip, Burnytė, Birutė, Calvo, Pier Luigi, Crushell, Ellen, Dalgıç, Buket, Das, Anibh M, Dezsőfi, Antal, Distelmaier, Felix, Fichtner, Alexander, Freisinger, Peter, Garbade, Sven F, Gaspar, Harald, Goujon, Louise, Hadzic, Nedim, Hartleif, Steffen, Hegen, Bianca, Hempel, Maja, Henning, Stephan, Hoerning, Andre, Houwen, Roderick, Hughes, Joanne, Iorio, Raffaele, Iwanicka-Pronicka, Katarzyna, Jankofsky, Martin, Junge, Norman, Kanavaki, Ino, Kansu, Aydan, Kaspar, Sonja, Kathemann, Simone, Kelly, Deidre, Kırsaçlıoğlu, Ceyda Tuna, Knoppke, Birgit, Kohl, Martina, Kölbel, Heike, Kölker, Stefan, Konstantopoulou, Vassiliki, Krylova, Tatiana, Kuloğlu, Zarife, Kuster, Alice, Laass, Martin W, Lainka, Elke, Lurz, Eberhard, Mandel, Hanna, Mayerhanser, Katharina, Mayr, Johannes A, McKiernan, Patrick, McLean, Patricia, McLin, Valerie, Mention, Karine, Müller, Hanna, Pasquier, Laurent, Pavlov, Martin, Pechatnikova, Natalia, Peters, Bianca, Petković Ramadža, Danijela, Piekutowska-Abramczuk, Dorota, Pilic, Denisa, Rajwal, Sanjay, Rock, Nathalie, Roetig, Agnès, Santer, René, Schenk, Wilfried, Semenova, Natalia, Sokollik, Christiane, Sturm, Ekkehard, Taylor, Robert W, Tschiedel, Eva, Urbonas, Vaidotas, Urreizti, Roser, Vermehren, Jan, Vockley, Jerry, Vogel, Georg-Friedrich, Wagner, Matias, van der Woerd, Wendy, Wortmann, Saskia B, Zakharova, Ekaterina, Hoffmann, Georg Friedrich, Meitinger, Thomas, Murayama, Kei, Staufner, Christian, Prokisch, Holger, MDL patientenzorg, Lenz, Dominic, Schlieben, Lea D, Shimura, Masaru, Bianzano, Alyssa, Smirnov, Dmitrii, Kopajtich, Robert, Berutti, Riccardo, Adam, Rüdiger, Aldrian, Denise, Baric, Ivo, Baumann, Ulrich, Bozbulut, Neslihan Eksi, Brugger, Melanie, Brunet, Theresa, Bufler, Philip, Burnytė, Birutė, Calvo, Pier Luigi, Crushell, Ellen, Dalgıç, Buket, Das, Anibh M, Dezsőfi, Antal, Distelmaier, Felix, Fichtner, Alexander, Freisinger, Peter, Garbade, Sven F, Gaspar, Harald, Goujon, Louise, Hadzic, Nedim, Hartleif, Steffen, Hegen, Bianca, Hempel, Maja, Henning, Stephan, Hoerning, Andre, Houwen, Roderick, Hughes, Joanne, Iorio, Raffaele, Iwanicka-Pronicka, Katarzyna, Jankofsky, Martin, Junge, Norman, Kanavaki, Ino, Kansu, Aydan, Kaspar, Sonja, Kathemann, Simone, Kelly, Deidre, Kırsaçlıoğlu, Ceyda Tuna, Knoppke, Birgit, Kohl, Martina, Kölbel, Heike, Kölker, Stefan, Konstantopoulou, Vassiliki, Krylova, Tatiana, Kuloğlu, Zarife, Kuster, Alice, Laass, Martin W, Lainka, Elke, Lurz, Eberhard, Mandel, Hanna, Mayerhanser, Katharina, Mayr, Johannes A, McKiernan, Patrick, McLean, Patricia, McLin, Valerie, Mention, Karine, Müller, Hanna, Pasquier, Laurent, Pavlov, Martin, Pechatnikova, Natalia, Peters, Bianca, Petković Ramadža, Danijela, Piekutowska-Abramczuk, Dorota, Pilic, Denisa, Rajwal, Sanjay, Rock, Nathalie, Roetig, Agnès, Santer, René, Schenk, Wilfried, Semenova, Natalia, Sokollik, Christiane, Sturm, Ekkehard, Taylor, Robert W, Tschiedel, Eva, Urbonas, Vaidotas, Urreizti, Roser, Vermehren, Jan, Vockley, Jerry, Vogel, Georg-Friedrich, Wagner, Matias, van der Woerd, Wendy, Wortmann, Saskia B, Zakharova, Ekaterina, Hoffmann, Georg Friedrich, Meitinger, Thomas, Murayama, Kei, Staufner, Christian, and Prokisch, Holger

Published
2024

5. Training in Paediatric Clinical Nutrition Across Europe: A Survey of the National Societies Network (2016–2019) of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition

Author

Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Baker, Alastair, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I., Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidotas, Kansu, Aydan, Georgieva, Miglena, and Koletzko, Berthold

Published
2022
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6. Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children

Author

Kalach, Nicolas, Zrinjka, Misak, Bontems, Patrick, Kori, Michal, Homan, Matjaz, Cabral, José, Casswall, Thomas, Chong, Sonny, Cilleruelo, Maria Luz, Faraci, Simona, Megraud, Francis, Papadopoulou, Alexandra, Pehlivanoglu, Ender, Raymond, Josette, Rea, Francesca, Maria, Rogalidou, Roma, Eleftheria, Tavares, Marta, Ugras, Meltem, Urbonas, Vaidotas, Urruzuno, Pedro, Gosset, Pierre, Creusy, Colette, Delebarre, Mathilde, and Verdun, Stephane

Published
2022
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7. Diagnosis and management of eosinophilic esophagitis in children: An update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)

Author

Amil-Dias, Jorge, Oliva, Salvatore, Papadopoulou, Alexandra, Thomson, Mike, Gutiérrez-Junquera, Carolina, Kalach, Nicolas, Orel, Rok, Auth, Marcus Karl-Heinz, Nijenhuis-Hendriks, Danielle, Strisciuglio, Caterina, Bauraind, Olivia, Chong, Sonny, Ortega, Gloria Dominguez, Férnandez, Sonia Férnandez, Furman, Mark, Garcia-Puig, Roger, Gottrand, Frederic, Homan, Matjaz, Huysentruyt, Koen, Kostovski, Aco, Otte, Sebastian, Rea, Francesca, Roma, Eleftheria, Romano, Claudio, Tzivinikos, Christos, Urbonas, Vaidotas, Velde, Saskia Vande, Zangen, Tsili, and Zevit, Noam

Abstract

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by symptoms of esophageal dysfunction and histologically by predominantly eosinophilic infiltration of the squamous epithelium. European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) published a guideline in 2014; however, the rapid evolution of knowledge about pathophysiology, diagnostic criteria, and therapeutic options have made an update necessary. A consensus group of pediatric gastroenterologists from the ESPGHAN Working Group on Eosinophilic Gastrointestinal Diseases (ESPGHAN EGID WG) reviewed the recent literature and proposed statements and recommendations on 28 relevant questions about EoE. A comprehensive electronic literature search was performed in MEDLINE, EMBASE, and Cochrane databases from 2014 to 2022. The Grading of Recommendations Assessment, Development and Evaluation system was used to assess the quality of evidence and formulate recommendations. A total of 52 statements based on the available evidence and 44 consensus-based recommendations are available. A revision of the diagnostic protocol, options for initial drug treatment, and the new concept of simplified empiric elimination diets are now available. Biologics are becoming a part of the potential armamentarium for refractory EoE, and systemic steroids may be considered as the initial treatment for esophageal strictures before esophageal dilation. The importance and assessment of quality of life and a planned transition to adult medical care are new areas addressed in this guideline. Research in recent years has led to a better understanding of childhood EoE. This guideline incorporates the new findings and provides a practical guide for clinicians treating children diagnosed with EoE. There is a discrepancy between symptoms and endoscopic and histologic features.Allergy testing is of no value in deciding which foods to eliminate.Eosinophilic esophagitis (EoE) may cause esophageal stenosis even in pediatric patients.Maintenance therapy after induction is necessary There is a discrepancy between symptoms and endoscopic and histologic features. Allergy testing is of no value in deciding which foods to eliminate. Eosinophilic esophagitis (EoE) may cause esophageal stenosis even in pediatric patients. Maintenance therapy after induction is necessary Validated tools are available for assessing symptoms and quality of life and should be incorporated in the management of children with EoE.Systemic steroids may be helpful in the treatment of severe esophageal strictures.A discrepancy between eosinophil depletion and symptomatic improvement requires reassessment of non-eosinophil-dependent inflammation.Implementation of programs for transition to adult care must be considered and started well before patients reach adulthood. Validated tools are available for assessing symptoms and quality of life and should be incorporated in the management of children with EoE. Systemic steroids may be helpful in the treatment of severe esophageal strictures. A discrepancy between eosinophil depletion and symptomatic improvement requires reassessment of non-eosinophil-dependent inflammation. Implementation of programs for transition to adult care must be considered and started well before patients reach adulthood.

Published
2024
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8. Helicobacter pylori infection found during upper endoscopy performed for the diagnosis of celiac, inflammatory bowel diseases, and eosinophilic esophagitis: A multicenter pediatric European study.

Author

Kotilea, Kallirroi, Romano, Claudio, Miele, Erasmo, Kindermann, Angelika, Dolstra, Yael, Misak, Zrinjka, Urbonas, Vaidotas, Sykora, Josef, Urruzuno, Pedro, Krauthammer, Alexander, Rogalidou, Maria, Dimakou, Konstantina, Zangen, Tsili, Roma, Eleftheria, Zellos, Aglaia, Cilleruelo, María Luz, M'Rini, Meline, Bontems, Patrick, Sahin, Yasin, and Tavares, Marta

Subjects
INFLAMMATORY bowel diseases, HELICOBACTER pylori infections, EOSINOPHILIC esophagitis, CELIAC disease, HELICOBACTER pylori, GASTROINTESTINAL diseases, ENDOSCOPY
Abstract

Background: Helicobacter pylori may be found during upper gastrointestinal endoscopy (UGE) performed to diagnose celiac disease (CeD), inflammatory bowel disease (IBD), and eosinophilic esophagitis (EoE). We aimed to describe the frequency of H. pylori in children undergoing UGE for CeD, IBD, and EoE and the number of children receiving eradication treatment. Materials and Methods: A retrospective multicenter study from 14 countries included pediatric patients diagnosed with CeD, IBD, and EoE between January 2019 and December 2021. Data collected: age, gender, hematologic parameters, endoscopic, histologic, and H. pylori culture results, and information on eradication treatment. Results: H. pylori was identified in 349/3890 (9%) children [167 (48%) male, median 12 years (interquartile range 8.1–14.6)]. H. pylori was present in 10% (173/1733) CeD, 8.5% (110/1292) IBD and 7.6% (66/865) EoE patients (p = NS). The prevalence differed significantly between Europe (Eastern 5.2% (28/536), Southern 3.8% (78/2032), Western 5.6% (28/513)) and the Middle East 26.6% (215/809) [odds ratio (OR) 7.96 95% confidence interval (CI) (6.31–10.1) p < 0.0001]. Eradication treatment was prescribed in 131/349 (37.5%) patients, 34.6% CeD, 35.8% IBD, and 56.1% EoE. Predictors for recommending treatment included erosions/ulcers [OR 6.45 95% CI 3.62–11.47, p < 0.0001] and nodular gastritis [OR 2.25 95% CI 1.33–3.81, p 0.003]. Treatment rates were higher in centers with a low H. pylori prevalence (<20%) [OR 3.36 95% CI 1.47–7.66 p 0.004]. Conclusions: Identifying H. pylori incidentally during UGE performed for the most common gastrointestinal diseases varies significantly among regions but not among diseases. The indications for recommending treatment are not well defined, and less than 40% of children received treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Genetic landscape of pediatric acute liver failure of indeterminate origin

Author

Lenz, Dominic, primary, Schlieben, Lea D., additional, Shimura, Masaru, additional, Bianzano, Alyssa, additional, Smirnov, Dmitrii, additional, Kopajtich, Robert, additional, Berutti, Riccardo, additional, Adam, Rüdiger, additional, Aldrian, Denise, additional, Baric, Ivo, additional, Baumann, Ulrich, additional, Bozbulut, Neslihan E., additional, Brugger, Melanie, additional, Brunet, Theresa, additional, Bufler, Philip, additional, Burnytė, Birutė, additional, Calvo, Pier L., additional, Crushell, Ellen, additional, Dalgiç, Buket, additional, Das, Anibh M., additional, Dezsőfi, Antal, additional, Distelmaier, Felix, additional, Fichtner, Alexander, additional, Freisinger, Peter, additional, Garbade, Sven F., additional, Gaspar, Harald, additional, Goujon, Louise, additional, Hadzic, Nedim, additional, Hartleif, Steffen, additional, Hegen, Bianca, additional, Hempel, Maja, additional, Henning, Stephan, additional, Hoerning, Andre, additional, Houwen, Roderick, additional, Hughes, Joanne, additional, Iorio, Raffaele, additional, Iwanicka-Pronicka, Katarzyna, additional, Jankofsky, Martin, additional, Junge, Norman, additional, Kanavaki, Ino, additional, Kansu, Aydan, additional, Kaspar, Sonja, additional, Kathemann, Simone, additional, Kelly, Deidre, additional, Kirsaçlioğlu, Ceyda T., additional, Knoppke, Birgit, additional, Kohl, Martina, additional, Kölbel, Heike, additional, Kölker, Stefan, additional, Konstantopoulou, Vassiliki, additional, Krylova, Tatiana, additional, Kuloğlu, Zarife, additional, Kuster, Alice, additional, Laass, Martin W., additional, Lainka, Elke, additional, Lurz, Eberhard, additional, Mandel, Hanna, additional, Mayerhanser, Katharina, additional, Mayr, Johannes A., additional, McKiernan, Patrick, additional, McClean, Patricia, additional, McLin, Valerie, additional, Mention, Karine, additional, Müller, Hanna, additional, Pasquier, Laurent, additional, Pavlov, Martin, additional, Pechatnikova, Natalia, additional, Peters, Bianca, additional, Petković Ramadža, Danijela, additional, Piekutowska-Abramczuk, Dorota, additional, Pilic, Denisa, additional, Rajwal, Sanjay, additional, Rock, Nathalie, additional, Roetig, Agnès, additional, Santer, René, additional, Schenk, Wilfried, additional, Semenova, Natalia, additional, Sokollik, Christiane, additional, Sturm, Ekkehard, additional, Taylor, Robert W., additional, Tschiedel, Eva, additional, Urbonas, Vaidotas, additional, Urreizti, Roser, additional, Vermehren, Jan, additional, Vockley, Jerry, additional, Vogel, Georg-Friedrich, additional, Wagner, Matias, additional, van der Woerd, Wendy, additional, Wortmann, Saskia B., additional, Zakharova, Ekaterina, additional, Hoffmann, Georg F., additional, Meitinger, Thomas, additional, Murayama, Kei, additional, Staufner, Christian, additional, and Prokisch, Holger, additional

Published
2023
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14. Helicobacter pylori Infection in Pediatric Patients Living in Europe: Results of the EuroPedHP Registry 2013 to 2016

Author

Kori, Michal, Le Thi, Thu Giang, Werkstetter, Katharina, Sustmann, Andrea, Bontems, Patrick, Lopes, Ana Isabel, Oleastro, Monica, Iwanczak, Barbara, Kalach, Nicolas, Misak, Zrinjka, Cabral, José, Homan, Matjaž, Cilleruelo Pascual, Maria Luz, Pehlivanoglu, Ender, Casswall, Thomas, Urruzuno, Pedro, Martinez Gomez, Maria José, Papadopoulou, Alexandra, Roma, Eleftheria, Dolinsek, Jernej, Rogalidou, Maria, Urbonas, Vaidotas, Chong, Sonny, Kindermann, Angelika, Miele, Erasmo, Rea, Francesca, Cseh, Áron, and Koletzko, Sibylle

Published
2020
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15. Vaccinations and Immunization Status in Pediatric Inflammatory Bowel Disease: A Multicenter Study From the Pediatric IBD Porto Group of the ESPGHAN

Author

Martinelli, Massimo, Giugliano, Francesca Paola, Strisciuglio, Caterina, Urbonas, Vaidotas, Serban, Daniela Elena, Banaszkiewicz, Aleksandra, Assa, Amit, Hojsak, Iva, Lerchova, Tereza, Navas-López, Víctor Manuel, Romano, Claudio, Sladek, Małgorzata, Veres, Gabor, Aloi, Marina, Kucinskiene, Ruta, and Miele, Erasmo

Published
2020
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16. Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER)

Author

Hoofien, Assaf, Dias, Jorge A., Malamisura, Monica, Rea, Francesca, Chong, Sonny, Oudshoorn, Johanna, Nijenhuis-Hendriks, Danielle, Otte, Sebastian, Papadopoulou, Alexandra, Romano, Claudio, Gottrand, Frederic, Miravet, Victor V., Orel, Rok, Oliva, Salvatore, Junquera, Carolina G., Załęski, Andrzej, Urbonas, Vaidotas, Garcia-Puig, Roger, Gomez, Maria J.M., Dominguez-Ortega, Gloria, Auth, Marcus K.-H., Kori, Michal, Ben Tov, Amir, Kalach, Nicolas, Velde, Saskia V., Furman, Mark, Miele, Erasmo, Marderfeld, Luba, Roma, Eleftheria, and Zevit, Noam

Published
2019
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17. Clinical Factors and Adverse Kidney Outcomes in Children With Antineutrophil Cytoplasmic Antibody–Associated Glomerulonephritis

Author

Marlais, Matko, primary, Wlodkowski, Tanja, additional, Printza, Nikoleta, additional, Kronsteiner, Dorothea, additional, Krisam, Regina, additional, Sauer, Lukas, additional, Aksenova, Marina, additional, Ashoor, Isa, additional, Awan, Atif, additional, Bacchetta, Justine, additional, Balasubramanian, Ramnath, additional, Basu, Biswanath, additional, Bekassy, Zivile, additional, Boyer, Olivia, additional, Chan, Eugene Yu-hin, additional, Csaicsich, Dagmar, additional, Decramer, Stéphane, additional, Dorresteijn, Eiske, additional, Drozynska-Duklas, Magdalena, additional, Eid, Loai Akram, additional, Espinosa, Laura, additional, Ferraris, Verónica, additional, Flögelová, Hana, additional, Forero-Delgadillo, Jessica, additional, Gianviti, Alessandra, additional, Gracchi, Valentina, additional, González, Mercedes López, additional, Hansen, Matthias, additional, Hattori, Motoshi, additional, Hong, Xu, additional, Hooman, Nakysa, additional, Ivanov, Dmytro, additional, Kang, Hee Gyung, additional, Karava, Vasiliki, additional, Kazyra, Ina, additional, Lungu, Adrian, additional, Marks, Stephen, additional, Maxted, Andrew, additional, Moczulska, Anna, additional, Müller, Rebekka, additional, Nastausheva, Tatiana, additional, Parolin, Mattia, additional, Pecoraro, Carmine, additional, Principi, Iliana, additional, Sanchez-Kazi, Cheryl, additional, Saygili, Seha, additional, Schild, Raphael, additional, Shenoy, Mohan, additional, Sinha, Rajiv, additional, Spizzirri, Ana Paula, additional, Stack, Maria, additional, Szczepanska, Maria, additional, Tsygin, Alexey, additional, Tzeng, Julia, additional, Urbonas, Vaidotas, additional, Zapata, Carlos, additional, Zieg, Jakub, additional, Schaefer, Franz, additional, Vivarelli, Marina, additional, and Tullus, Kjell, additional

Published
2023
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18. Training in pediatric hepatology across Europe

Author

Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I., Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidotas, Kansu, Aydan, Georgieva, Miglena, Baker, Alastair, Kelly, Deirdre, Ribes-Koninckxh, Carmen, Furlano, Raoul, I, and Pediatrics

Subjects
Science & Technology, training, children, Hepatology, nutrition, pediatric gastroenterology, Gastroenterology & Hepatology, Gastroenterology, ADOLESCENT, GUIDELINES, DISEASE, PERCUTANEOUS LIVER-BIOPSY, Training, pediatric hepatology, Europe, survey, Life Sciences & Biomedicine, ADULT HEALTH-CARE, POSITION PAPER, TRANSITION
Abstract

BACKGROUND: The widely recognized burden of liver diseases makes training in pediatric hepatology (PH) imperative. The aim of this survey, which was part of a global survey on training in pediatric gastroenterology, hepatology and nutrition (PGHN) across Europe, was to assess the PH and liver transplantation (LT) infrastructure, staff and training programs in PGHN training centers. METHOD: Standardized questionnaires were collected from training centers via the presidents/representatives of the National Societies Network of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) from June 2016 to December 2019. RESULTS: A total of 100 PGHN training centers participated in the survey (14/100 were national referral centers in PH and/or LT). Dedicated PH clinics were available in 75%, but LT clinics in only 11%. Dedicated beds for PGHN inpatients were available in 47/95 (49%) centers. Full-time or part-time specialists for PH care were available in 31/45 (69%) and 11/36 (31%) centers, respectively. Liver biopsies (LB) were performed in 93% of centers by: a PGHN specialist (35%); an interventional radiologist (26%); a pediatric surgeon (4%); or a combination of them (35%). Dividing the annual number of LBs in the centers performing LBs by the number of trainees gave a median (range) of 10 (1-125) per trainee. Transient elastography was available in 60/92 (65%) of centers. CONCLUSIONS: The survey highlighted the differences and shortcomings in PH training across Europe. ESPGHAN should take initiatives together with National Societies to ensure the acquisition of PH knowledge and skills according to the ESPGHAN curriculum.An infographic is available for this article at: http://www.annalsgastro.gr/files/journals/1/earlyview/2022/Infographic-Hepatology-training-paper.pdf. ispartof: ANNALS OF GASTROENTEROLOGY vol:35 issue:2 pages:187-+ ispartof: location:Greece status: published

Published
2022

19. Clinical factors and adverse kidney outcomes in children with ANCA-Associated Glomerulonephritis

Author

Marlais, Matko, Wlodkowski, Tanja, Printza, Nikoleta, Kronsteiner, Dorothea, Krisam, Regina, Sauer, Lukas, Aksenova, Marina, Ashoor, Isa, Awan, Atif, Bacchetta, Justine, Balasubramanian, Ramnath, Basu, Biswanath, Bekassy, Zivile, Boyer, Olivia, Chan, Eugene Yu-Hin, Csaicsich, Dagmar, Decramer, Stéphane, Dorresteijn, Eiske, Drozynska-Duklas, Magdalena, Eid, Loai Akram, Espinosa, Laura, Ferraris, Verónica, Flögelová, Hana, Forero-Delgadillo, Jessica, Gianviti, Alessandra, Gracchi, Valentina, López González, Mercedes, Hansen, Matthias, Hattori, Motoshi, Hong, Xu, Hooman, Nakysa, Ivanov, Dmytro, Kang, Hee Gyung, Karava, Vasiliki, Kazyra, Ina, Lungu, Adrian, Marks, Stephen, Maxted, Andrew, Moczulska, Anna, Müller, Rebekka, Nastausheva, Tatiana, Parolin, Mattia, Pecoraro, Carmine, Principi, Iliana, Sanchez-Kazi, Cheryl, Saygili, Seha, Schild, Raphael, Shenoy, Mohan, Sinha, Rajiv, Spizzirri, Ana Paula, Stack, Maria, Szczepanska, Maria, Tsygin, Alexey, Tzeng, Julia, Urbonas, Vaidotas, Zapata, Carlos, Zieg, Jakub, Schaefer, Franz, Vivarelli, Marina, and Tullus, Kjell

Published
2023

20. Pediatric endoscopy training across Europe: a survey of the ESPGHAN National Societies Network 2016–2019

Author

Papadopoulou, Alexandra, additional, Ribes-Koninckx, Carmen, additional, Baker, Alastair, additional, Noni, Maria, additional, Koutri, Eleni, additional, Karagianni, Maria-Vasiliki, additional, Protheroe, Sue, additional, Guarino, Alfredo, additional, Mas, Emmanuel, additional, Wilschanski, Michael, additional, Roman, Enriqueta, additional, Escher, Johanna, additional, Furlano, Raoul I., additional, Posovszky, Carsten, additional, Hoffman, Ilse, additional, Bronsky, Jiri, additional, Hauer, Almuthe Christine, additional, Tjesic-Drinkovic, Duska, additional, Fotoulaki, Maria, additional, Orel, Rok, additional, Urbonas, Vaidotas, additional, Kansu, Aydan, additional, Georgieva, Miglena, additional, and Thomson, Mike, additional

Published
2022
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21. Association of training standards in pediatric gastroenterology, hepatology and nutrition in European training centers with formal national recognition of the subspecialty:a survey of the ESPGHAN National Societies Network 2016-2019

Author

Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Baker, Alastair, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I., Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidotas, Kansu, Aydan, Georgieva, Miglena, Thomson, Mike, Benninga, Marc, Thapar, Nikhil, Kelly, Deirdre, Koletzko, Berthold, Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Baker, Alastair, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I, Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidota, Kansu, Aydan, Georgieva, Miglena, Thomson, Mike, Benninga, Marc, Thapar, Nikhil, Kelly, Deirdre, Koletzko, Berthold, and Pediatrics

Subjects
Science & Technology, Gastroenterology & Hepatology, SYLLABUS, Gastroenterology, Training in pediatric gastroenterology, hepatology and nutrition, ESPGHAN, GUIDELINES, Life Sciences & Biomedicine
Abstract

BACKGROUND: This survey evaluated the effects of the recognition of pediatric gastroenterology, hepatology and nutrition (PGHN) on European PGHN training centers. METHOD: Standardized questionnaires were collected from training centers via the presidents/representatives of the National Societies Network of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition, from June 2016 to December 2019. RESULTS: A total of 100 training centers from 19 countries participated in the survey: 55 from 12 countries where PGHN is formally recognized (Group 1) and 45 from 7 countries where it is not (Group 2). Training centers in Group 2 were less likely to have an integrated endoscopy suite, a written training curriculum and a training lead (P=0.059, P

Published
2022

22. Management of Helicobacter pylori infection in paediatric patients in Europe: results from the EuroPedHp Registry

Author

Le Thi, Thu Giang, Werkstetter, Katharina, Kotilea, Kallirroi, Bontems, Patrick, Cabral, José, Cilleruelo Pascual, Maria Luz, Kori, Michal, Barrio, Josefa, Homan, Matjaž, Kalach, Nicolas, Lima, Rosa, Tavares, Marta, Urruzuno, Pedro, Misak, Zrinjka, Urbonas, Vaidotas, Koletzko, Sibylle, Sykora, Josef, Miele, Erasmo, Krahl, Andreas, Klemenak, Martina, Papadopoulou, Alexandra, Chiaro, Andrea, Ugras, Meltem, de Laffolie, Jan, Matusiewics, Krzysztof, Rea, Francesca, Casswall, Thomas, Roma, Eleftheria, Banoub, Hany, Cseh, Áron, Rogalidou, Maria, Lopes, Ana Isabel, Le Thi, Thu Giang, Werkstetter, Katharina, Kotilea, Kallirroi, Bontems, Patrick, Cabral, José, Cilleruelo Pascual, Maria Luz, Kori, Michal, Barrio, Josefa, Homan, Matjaž, Kalach, Nicolas, Lima, Rosa, Tavares, Marta, Urruzuno, Pedro, Misak, Zrinjka, Urbonas, Vaidotas, Koletzko, Sibylle, Sykora, Josef, Miele, Erasmo, Krahl, Andreas, Klemenak, Martina, Papadopoulou, Alexandra, Chiaro, Andrea, Ugras, Meltem, de Laffolie, Jan, Matusiewics, Krzysztof, Rea, Francesca, Casswall, Thomas, Roma, Eleftheria, Banoub, Hany, Cseh, Áron, Rogalidou, Maria, and Lopes, Ana Isabel

Abstract

Purpose: The EuroPedHp-registry aims to monitor guideline-conform management, antibiotic resistance, and eradication success of 2-week triple therapy tailored to antibiotic susceptibility (TTT) in Helicobacter pylori-infected children. Methods: From 2017 to 2020, 30 centres from 17 European countries reported anonymized demographic, clinical, antibiotic susceptibility, treatment, and follow-up data. Multivariable logistic regression identified factors associated with treatment failure. Results: Of 1605 patients, 873 had follow-up data (53.2% female, median age 13.0 years, 7.5% with ulcer), thereof 741 (85%) treatment naïve (group A) and 132 (15%) after failed therapy (group B). Resistance to metronidazole was present in 21% (A: 17.7%, B: 40.2%), clarithromycin in 28.8% (A: 25%, B: 51.4%), and both in 7.1% (A: 3.8%, B: 26.5%). The majority received 2-week tailored triple therapy combining proton pump inhibitor (PPI), amoxicillin with clarithromycin (PAC) or metronidazole (PAM). Dosing was lower than recommended for PPI (A: 49%, B: 41%) and amoxicillin (A: 6%, B: 56%). In treatment naïve patients, eradication reached 90% (n = 503, 95% CI 87–93%) and 93% in compliant children (n = 447, 95% CI 90–95%). Tailored triple therapy cured 59% patients after failed therapy (n = 69, 95% CI 48–71%). Treatment failure was associated with PAM in single clarithromycin resistance (OR = 2.47, 95% CI 1.10–5.53), with PAC in single metronidazole resistance (OR = 3.44, 95% CI 1.47–8.08), and with low compliance (OR = 5.89, 95% CI 2.49–13.95). Conclusions: Guideline-conform 2-weeks therapy with PPI, amoxicillin, clarithromycin or metronidazole tailored to antibiotic susceptibility achieves primary eradication of ≥ 90%. Higher failure rates in single-resistant strains despite tailored treatment indicate missed resistance by sampling error., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

23. Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children

Author

Kalach, Nicolas Zrinjka, Misak Bontems, Patrick Kori, Michal and Homan, Matjaz Cabral, Jose Casswall, Thomas Chong, Sonny and Cilleruelo, Maria Luz Faraci, Simona Megraud, Francis and Papadopoulou, Alexandra Pehlivanoglu, Ender Raymond, Josette and Rea, Francesca Maria, Rogalidou Roma, Eleftheria Tavares, Marta Ugras, Meltem Urbonas, Vaidotas Urruzuno, Pedro and Gosset, Pierre Creusy, Colette Delebarre, Mathilde Verdun, Stephane ESPGHAN-Helicobacter Pylori Specia

Abstract

Objectives: A descriptive and comparative study of gastric histological aspects according to the updated Sydney classification (USC), obtained from Helicobacter pylori-positive versus H pylori-negative children referred for upper gastrointestinal endoscopy. Methods: The Prisma method was used to perform a systematic review and meta-analysis. Selection criteria were based on following key words USC, H pylori, children, endoscopy, or biopsy. Publication biases were assessed according to the Newcastle-Ottawa Scale, and a meta-regression analysis was done. The study was registered on the PROSPERO platform. Results: Between 1994 and 2017, 1238 references were found; 97 studies were retained for the systematic review with a total number of 25,867 children; 75 studies were selected for the meta-analysis concerning 5990 H pylori-infected and 17,782 uninfected children. H pylori-positive versus H pylori-negative children, according to the USC, showed significantly higher relative risk for gastric antral and corpus chronic inflammation, presence of neutrophils, and of lymphoid follicles, and gastric mucosa atrophy, whereas, intestinal metaplasia showed a significantly higher RR only in antral biopsies. The meta-regression analysis showed that H pylori-positive versus H pylori-negative children had significantly higher risk only for corpus activity according to age, recurrent abdominal pain, and geographical area of low H pylori prevalence. Conclusions: H pylori infection in children was associated with higher relative risk for gastric antral and corpus chronic inflammation, presence of neutrophils, lymphoid follicles, and rare gastric mucosa atrophy, whereas, rare intestinal metaplasia was only significantly higher in the antral area.

Published
2022

24. Characterization of Eosinophilic Esophagitis From the European Pediatric Eosinophilic Esophagitis Registry (pEEr) of ESPGHAN

Author

Oliva, Salvatore, Dias, Jorge Amil, Rea, Francesca, Malamisura, Monica, Espinheira, Maria Céu, Papadopoulou, Alexandra, Koutri, Eleni, Rossetti, Danilo, Orel, Rok, Homan, Matjaž, Bauraind, Olivia, Auth, Marcus Karl-Heinz, Junquera, Carolina Gutierrez, Vande Velde, Saskia, Kori, Michal, Huysentruyt, Koen, Urbonas, Vaidotas, Roma, Eleftheria, Fernández, Sonia Fernández, Domínguez-Ortega, Gloria, Zifman, Eyal, Kafritsa, Panayota, Miele, Erasmo, Zevit, Noam, Oliva, Salvatore, Dias, Jorge Amil, Rea, Francesca, Malamisura, Monica, Espinheira, Maria Céu, Papadopoulou, Alexandra, Koutri, Eleni, Rossetti, Danilo, Orel, Rok, Homan, Matjaž, Bauraind, Olivia, Auth, Marcus Karl-Heinz, Junquera, Carolina Gutierrez, Vande Velde, Saskia, Kori, Michal, Huysentruyt, Koen, Urbonas, Vaidota, Roma, Eleftheria, Fernández, Sonia Fernández, Domínguez-Ortega, Gloria, Zifman, Eyal, Kafritsa, Panayota, Miele, Erasmo, Zevit, Noam, Clinical sciences, Growth and Development, and Pediatrics

Subjects
Proton Pump Inhibitors/therapeutic use, Male, Delayed Diagnosis, Adolescent, gastroenterology, Proton Pump Inhibitors, Eosinophilic Esophagitis, Endoscopy, Gastrointestinal, Enteritis, Eosinophilic Esophagitis/complications, Child, Preschool, Gastritis, Pediatrics, Perinatology and Child Health, Eosinophilia, Humans, Female, Deglutition Disorders/drug therapy, Pediatrics, Perinatology, and Child Health, Registries, Child, Deglutition Disorders, Food Hypersensitivity
Abstract

OBJECTIVES: Few pediatric data on phenotypic aspects of eosinophilic esophagitis (EoE) are available. The pEEr registry was developed to prospectively characterize children with EoE from Europe and Israel. METHODS: pEEr is an ongoing prospective registry enrolling children with esophageal eosinophilia (≥15 eos/HPF). Anonymized data were collected from 19 pediatric centers. Data regarding demographics, clinical manifestations, endoscopy, histology, and therapies were collected. RESULTS: A total of 582 subjects (61% male) were analyzed. The median age at diagnosis was 10.5 years [interquartile range (IQR): 5.7-17.7], whereas the age at symptom onset was 9.2 years (IQR: 4.3-16.4), resulting in a median diagnostic delay of 1.2 years (IQR: 0.7-2.3). The diagnostic delay was longer below age

Published
2022

26. Cold Ischemia Time and Graft Fibrosis Are Associated with Autoantibodies after Pediatric Liver Transplantation: A Retrospective Cohort Study of the European Reference Network TransplantChild

Author

Junge, Norman, primary, Di Giorgio, Angelo, additional, Girard, Muriel, additional, Demir, Zeynep, additional, Kaminska, Diana, additional, Janowska, Maria, additional, Urbonas, Vaidotas, additional, Varnas, Dominykas, additional, Maggiore, Giuseppe, additional, Alterio, Tommaso, additional, Leiskau, Christoph, additional, Vondran, Florian W. R., additional, Richter, Nicolas, additional, D’Antiga, Lorenzo, additional, Mikolajczyk, Rafael, additional, Pfister, Eva-Doreen, additional, and Baumann, Ulrich, additional

Published
2022
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28. Systematic Review and Meta-analysis of Histological Gastric Biopsy Aspects According to the Updated Sydney System in Children

Author

Kalach, Nicolas, primary, Zrinjka, Misak, additional, Bontems, Patrick, additional, Kori, Michal, additional, Homan, Matjaz, additional, Cabral, José, additional, Casswall, Thomas, additional, Chong, Sonny, additional, Cilleruelo, Maria Luz, additional, Faraci, Simona, additional, Megraud, Francis, additional, Papadopoulou, Alexandra, additional, Pehlivanoglu, Ender, additional, Raymond, Josette, additional, Rea, Francesca, additional, Maria, Rogalidou, additional, Roma, Eleftheria, additional, Tavares, Marta, additional, Ugras, Meltem, additional, Urbonas, Vaidotas, additional, Urruzuno, Pedro, additional, Gosset, Pierre, additional, Creusy, Colette, additional, Delebarre, Mathilde, additional, and Verdun, Stephane, additional

Published
2021
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31. Nuotolinis vaikų ugdymas pandemijos dėl COVID-19 metu: grėsmės ir galimybės ekosisteminiu požiūriu

Author

Jusienė, Roma, primary, Būdienė, Virginija, additional, Gintilienė, Gražina, additional, Girdzijauskienė, Sigita, additional, Stonkuvienė, Irena, additional, Žėkaitė, Jovita, additional, Adomaitytė Subačienė, Ieva, additional, Baukienė, Edita, additional, Breidokienė, Rima, additional, Buzaitytė-Kašalynienė, Jolita, additional, Dragūnevičius, Kęstutis, additional, Grabauskienė, Vaiva, additional, Praninskienė, Rūta, additional, Schoroškienė, Vaiva, additional, Speičytė-Ruschhoff, Erika, additional, and Urbonas, Vaidotas, additional

Published
2021
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32. Primary child health care services in Lithuania: Does it meet the needs of the children?

Author

Burokiene, Sigita, Sutkus, Viktoras, Vaideliene, Laimute, Urbonas, Vaidotas, Kevalas, Rimantas, Labanauskas, Liutauras, Usonis, Vytautas, and Jankauskiene, Augustina

Subjects
PARENT attitudes, RETROSPECTIVE studies, PRIMARY health care, SURVEYS, CHILD health services, DESCRIPTIVE statistics, MEDICAL needs assessment, LONGITUDINAL method, TRUST
Abstract

Background: Primary health care is the foundation of a health system and has a strong influence on the efficiency of the health system as a whole. For children in Europe, it is defined by three primary health care models: paediatric; mixed paediatrician and family physician; and family physician. There is much debate in Europe about which model is most appropriate for children. The Lithuanian model is mixed, although health policy is geared towards the promotion of family physicians, with a decline in the number of primary paediatricians in clinical practice. Objectives: To review the children's primary health care system in Lithuania, compare the indicators of primary care by family physicians and paediatricians in Lithuania, and identify parents' perceptions of the primary health care model for children. Methods: A retrospective longitudinal study was performed of children's primary health care indicators for quantity and quality in 2014–2018. A representative opinion survey of 1000 adult respondents was conducted. Results: A total of 3.5 million children's visits to primary care physicians (6.7 ± 3 visits for each child) were registered in Lithuania in 2018. During a recent 5‐year period (2014–2018), the number of visits did not change significantly. Visits to paediatricians accounted for 41% of all children's visits to primary care physicians in 2018. Visits to Emergency Departments increased by 20%. The results of the survey showed that 72.3% of the respondents would prefer their children be treated by a primary care paediatrician. Conclusion: The mixed paediatrician and family physician health care model gives parents the right to choose. The results showed a decreased number of paediatricians in primary care; paediatric primary care is more frequent than family physician care; and parents tend to trust paediatricians more. The study also showed differences in the models of service used and patterns between regions in Lithuania. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Corrigendum to: Diagnostic Yield of Next-Generation Sequencing in Very Early-Onset Inflammatory Bowel Diseases: A Multicenter Study

Author

Charbit-Henrion, Fabienne, primary, Parlato, Marianna, additional, Hanein, Sylvain, additional, Duclaux-Loras, Rémi, additional, Nowak, Jan, additional, Begue, Bernadette, additional, Rakotobe, Sabine, additional, Bruneau, Julie, additional, Fourrage, Cécile, additional, Alibeu, Olivier, additional, Rieux-Laucat, Frédéric, additional, Lévy, Eva, additional, Stolzenberg, Marie-Claude, additional, Mazerolles, Fabienne, additional, Latour, Sylvain, additional, Lenoir, Christelle, additional, Fischer, Alain, additional, Picard, Capucine, additional, Aloi, Marina, additional, Dias, Jorge Amil, additional, Hariz, Mongi Ben, additional, Bourrier, Anne, additional, Breuer, Christian, additional, Breton, Anne, additional, Bronsky, Jiri, additional, Buderus, Stephan, additional, Cananzi, Mara, additional, Coopman, Stéphanie, additional, Crémilleux, Clara, additional, Dabadie, Alain, additional, Dumant-Forest, Clémentine, additional, Gurkan, Odul Egritas, additional, Fabre, Alexandre, additional, Fischer, Aude, additional, Diaz, Marta German, additional, Gonzalez-Lama, Yago, additional, Goulet, Olivier, additional, Guariso, Graziella, additional, Gurcan, Neslihan, additional, Homan, Matjaz, additional, Hugot, Jean-Pierre, additional, Jeziorski, Eric, additional, Karanika, Evi, additional, Lachaux, Alain, additional, Lewindon, Peter, additional, Lima, Rosa, additional, Magro, Fernando, additional, Major, Janos, additional, Malamut, Georgia, additional, Mas, Emmanuel, additional, Mattyus, Istvan, additional, Mearin, Luisa M, additional, Melek, Jan, additional, Navas-Lopez, Victor Manuel, additional, Paerregaard, Anders, additional, Pelatan, Cecile, additional, Pigneur, Bénédicte, additional, Pais, Isabel Pinto, additional, Rebeuh, Julie, additional, Romano, Claudio, additional, Siala, Nadia, additional, Strisciuglio, Caterina, additional, Tempia-Caliera, Michela, additional, Tounian, Patrick, additional, Turner, Dan, additional, Urbonas, Vaidotas, additional, Willot, Stéphanie, additional, Ruemmele, Frank M, additional, and Cerf-Bensussan, Nadine, additional

Published
2020
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35. Differences in Management of Eosinophilic Esophagitis in Europe: An Assessment of Current Practice

Author

Tourlamain, Gilles, primary, Garcia-Puig, Roger, additional, Gutiérrez-Junquera, Carolina, additional, Papadopoulou, Alexandra, additional, Roma, Eleftheria, additional, Kalach, Nicolas, additional, Oudshoorn, Johanna, additional, Sokollik, Christiane, additional, Karolewska-Bochenek, Kasia, additional, Oliva, Salvatore, additional, Strisciuglio, Caterina, additional, Bauraind, Olivia, additional, Auth, Marcus Karl-Heinz, additional, Thomson, Mike, additional, Otte, Sebastian, additional, Rok, Orel, additional, Dias, Jorge Amil, additional, Tzivinikos, Christos, additional, Urbonas, Vaidotas, additional, Kostovski, Aco, additional, Zevit, Noam, additional, and Velde, Saskia Vande, additional

Published
2020
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36. Diagnostic yield of next-generation sequencing in very early-onset inflammatory bowel diseases: A multicentre study

Author

Charbit-Henrion, Fabienne, Parlato, Marianna, Hanein, Sylvain, Duclaux-Loras, Remi, Nowak, Jan, Bègue, Bernadette, Rakotobe, Sabine, Bruneau, Julie, Fourrage, Cécile, Alibeu, Olivier, Rieux-Laucat, Frédéric, Lévy, Eva, Stolzenberg, Marie-Claude, Mazerolles, Fabienne, Latour, Sylvain, Lenoir, Christelle, Fischer, Alain, Picard, Capucine, Aloi, Marina, Amil Dias, Jorge, Ben Hariz, Mongi, Bourrier, Anne, Breuer, Christian, Breton, Anne, Bronski, Jiri, Buderus, Stephan, Cananzi, Mara, Coopman, Stéphanie, Crémilleux, Clara, Dabadie, Alain, Dumant-Forest, Clémentine, Egritas Gurkan, Odul, Fabre, Alexandre, Fischer, Aude, German Diaz, Marta, Gonzalez-Lama, Yago, Goulet, Olivier, Guariso, Graziella, Gurcan, Neslihan, Homan, Matjaz, Hugot, Jean-Pierre, Jeziorski, Eric, Karanika, Evi, Lachaux, Alain, Lewindon, Peter, Lima, Rosa, Magro, Fernando, Major, Janos, Malamut, Georgia, Mas, Emmanuel, Mattyus, Istvan, Mearin, Luisa, Melek, Jan, Navas-Lopez, Victor Manuel, Paerregaard, Anders, Pelatan, Cecile, Pigneur, Bénédicte, Pinto Pais, Isabel, Rebeuh, Julie, Romano, Claudio, Siala, Nadia, Strisciuglio, Caterina, Tempia-Caliera, Michela, Tounian, Patrick, Turner, Dan, Urbonas, Vaidotas, Willot, Stéphanie, Ruemmele, Frank, Cerf-Bensussan, Nadine, Charbit-Henrion, Fabienne, Parlato, Marianna, Hanein, Sylvain, Duclaux-Loras, Rémi, Nowak, Jan, Begue, Bernadette, Rakotobe, Sabine, Bruneau, Julie, Fourrage, Cécile, Alibeu, Olivier, Rieux-Laucat, Frédéric, Lévy, Eva, Stolzenberg, Marie-Claude, Mazerolles, Fabienne, Latour, Sylvain, Lenoir, Christelle, Fischer, Alain, Picard, Capucine, Aloi, Marina, Dias, Jorge Amil, Hariz, Mongi Ben, Bourrier, Anne, Breuer, Christian, Breton, Anne, Bronski, Jiri, Buderus, Stephan, Cananzi, Mara, Coopman, Stéphanie, Crémilleux, Clara, Dabadie, Alain, Dumant-Forest, Clémentine, Gurkan, Odul Egrita, Fabre, Alexandre, Fischer, Aude, Diaz, Marta German, Gonzalez-Lama, Yago, Goulet, Olivier, Guariso, Graziella, Gurcan, Neslihan, Homan, Matjaz, Hugot, Jean-Pierre, Jeziorski, Eric, Karanika, Evi, Lachaux, Alain, Lewindon, Peter, Lima, Rosa, Magro, Fernando, Major, Jano, Malamut, Georgia, Mas, Emmanuel, Mattyus, Istvan, Mearin, Luisa M, Melek, Jan, Navas-Lopez, Victor Manuel, Paerregaard, Ander, Pelatan, Cecile, Pigneur, Bénédicte, Pais, Isabel Pinto, Rebeuh, Julie, Romano, Claudio, Siala, Nadia, Strisciuglio, Caterina, Tempia-Caliera, Michela, Tounian, Patrick, Turner, Dan, Urbonas, Vaidota, Willot, Stéphanie, Ruemmele, Frank M., Cerf-Bensussan, Nadine, Laboratory of Intestinal Immunity (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), The Clinical Bioinformatics laboratory (Equipe Inserm U1163), Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunogenetics of pediatric autoimmune diseases (Equipe Inserm U1163), Chaire Médecine expérimentale (A. Fischer), Collège de France (CdF (institution)), GENIUS Group, Service de Gastroentérologie et nutrition [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Pédiatrie, Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Service de pédiatrie médicale et médecine de l'adolescent [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain], Gastroentérologie-Hépatologie et Nutrition Pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Hospital de São João [Porto], Service de gastroenterologie [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Le Mans (CH Le Mans), University of Messina, Department of Pediatrics, Centre Hospitalier Universitaire Mongi Slim [La Marsa], CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service de Gastroentérologie, d'hépatologie et nutrition pédiatrique [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), CHU Le MAns, Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Curie-Université Paris Descartes - Paris 5 (UPD5), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), and Institut Curie-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, paediatric, VEO-IBD, Adolescent, monogenic disorder, Gastroenterology, High-Throughput Nucleotide Sequencing, Infant, Genetics and molecular epidemiology, Inflammatory Bowel Diseases, monogenic disorders, Corrigenda, Cohort Studies, paediatrics, Predictive Value of Tests, Child, Preschool, TNGS, Humans, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Age of Onset, Child, Genetics and molecular epidemiology, monogenic disorders, paediatrics, TNGS, VEO-IBD, Gastroenterology, AcademicSubjects/MED00260
Abstract

Background and Aims An expanding number of monogenic defects have been identified as causative of severe forms of very early-onset inflammatory bowel diseases [VEO-IBD]. The present study aimed at defining how next-generation sequencing [NGS] methods can be used to improve identification of known molecular diagnosis and to adapt treatment. Methods A total of 207 children were recruited in 45 paediatric centres through an international collaborative network [ESPGHAN GENIUS working group] with a clinical presentation of severe VEO-IBD [n = 185] or an anamnesis suggestive of a monogenic disorder [n = 22]. Patients were divided at inclusion into three phenotypic subsets: Predominantly small bowel inflammation, colitis with perianal lesions, and colitis only. Methods to obtain molecular diagnosis included functional tests followed by specific Sanger sequencing, custom-made targeted NGS, and in selected cases whole exome sequencing [WES] of parents-child trios. Genetic findings were validated clinically and/or functionally. Results Molecular diagnosis was achieved in 66/207 children [32%]: 61% with small bowel inflammation, 39% with colitis and perianal lesions, and 18% with colitis only. Targeted NGS pinpointed gene mutations causative of atypical presentations, and identified large exonic copy number variations previously missed by WES. Conclusions Our results lead us to propose an optimised diagnostic strategy to identify known monogenic causes of severe IBD.

Published
2018

37. Vaccinations and Immunization Status in Pediatric Inflammatory Bowel Disease: A Multicenter Study From the Pediatric IBD Porto Group of the ESPGHAN

Author

Martinelli, Massimo, primary, Giugliano, Francesca Paola, additional, Strisciuglio, Caterina, additional, Urbonas, Vaidotas, additional, Serban, Daniela Elena, additional, Banaszkiewicz, Aleksandra, additional, Assa, Amit, additional, Hojsak, Iva, additional, Lerchova, Tereza, additional, Navas-López, Víctor Manuel, additional, Romano, Claudio, additional, Sladek, Małgorzata, additional, Veres, Gabor, additional, Aloi, Marina, additional, Kucinskiene, Ruta, additional, and Miele, Erasmo, additional

Published
2019
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43. Helicobacter pyloriInfection in Pediatric Patients Living in Europe

Author

Kori, Michal, Le Thi, Thu Giang, Werkstetter, Katharina, Sustmann, Andrea, Bontems, Patrick, Lopes, Ana Isabel, Oleastro, Monica, Iwanczak, Barbara, Kalach, Nicolas, Misak, Zrinjka, Cabral, José, Homan, Matjaž, Cilleruelo Pascual, Maria Luz, Pehlivanoglu, Ender, Casswall, Thomas, Urruzuno, Pedro, Martinez Gomez, Maria José, Papadopoulou, Alexandra, Roma, Eleftheria, Dolinsek, Jernej, Rogalidou, Maria, Urbonas, Vaidotas, Chong, Sonny, Kindermann, Angelika, Miele, Erasmo, Rea, Francesca, Cseh, Áron, and Koletzko, Sibylle

Abstract

The aim of the study was to assess clinical presentation, endoscopic findings, antibiotic susceptibility and treatment success of Helicobacter pylori(H. pylori) infected pediatric patients. Between 2013 and 2016, 23 pediatric hospitals from 17 countries prospectively submitted data on consecutive H. pylori-infected (culture positive) patients to the EuroPedHP-Registry. Of 1333 patients recruited (55.1% girls, median age 12.6 years), 1168 (87.6%) were therapy naïve (group A) and 165 (12.4%) had failed treatment (group B). Patients resided in North/Western (29.6%), Southern (34.1%) and Eastern Europe (23.0%), or Israel/Turkey (13.4%). Main indications for endoscopy were abdominal pain or dyspepsia (81.2%, 1078/1328). Antral nodularity was reported in 77.8% (1031/1326) of patients, gastric or duodenal ulcers and erosions in 5.1% and 12.8%, respectively. Primary resistance to clarithromycin (CLA) and metronidazole (MET) occurred in 25% and 21%, respectively, and increased after failed therapy. Bacterial strains were fully susceptible in 60.5% of group A, but in only 27.4% of group B. Primary CLA resistance was higher in Southern and Eastern Europe (adjusted odds ratio [ORadj] = 3.44, 95% confidence interval [CI] 2.22–5.32, P< 0.001 and 2.62, 95% CI: 1.63–4.22, P< 0.001, respectively) compared with Northern/Western Europe. Children born outside Europe showed higher primary MET resistance (ORadj= 3.81, 95% CI: 2.25–6.45, P< 0.001). Treatment success in group A reached only 79.8% (568/712) with 7 to 14 days triple therapy tailored to antibiotic susceptibility. Peptic ulcers are rare in dyspeptic H. pylori-infected children. Primary resistance to CLA and MET is markedly dependent on geographical regions of birth and residence. The ongoing survey will show whether implementation of the updated ESPGHAN/NASPGHAN guidelines will improve the eradication success.

Published
2020
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45. Pediatric Eosinophilic Esophagitis

Author

Hoofien, Assaf, Dias, Jorge A., Malamisura, Monica, Rea, Francesca, Chong, Sonny, Oudshoorn, Johanna, Nijenhuis-Hendriks, Danielle, Otte, Sebastian, Papadopoulou, Alexandra, Romano, Claudio, Gottrand, Frederic, Miravet, Victor V., Orel, Rok, Oliva, Salvatore, Junquera, Carolina G., Zaleski, Andrzej, Urbonas, Vaidotas, Garcia-Puig, Roger, Gomez, Maria J.M., Dominguez-Ortega, Gloria, Auth, Marcus K.-H., Kori, Michal, Ben Tov, Amir, Kalach, Nicolas, Velde, Saskia V., Furman, Mark, Miele, Erasmo, Marderfeld, Luba, Roma, Eleftheria, and Zevit, Noam

Abstract

Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists diagnosing and treating EoE and to identify the triggering allergens in European children. Retrospective anonymized data were collected from 26 European pediatric gastroenterology centers in 13 countries. Inclusion criteria were: Patients diagnosis with EoE, completed investigations prescribed by the treating physician, and were on stable medical or dietary interventions. In total, 410 patients diagnosed between December 1999 and June 2016 were analyzed, 76.3% boys. The time from symptoms to diagnosis was 12 ± 33.5 months and age at diagnosis was 8.9 ± 4.75 years. The most frequent indications for endoscopy were: dysphagia (38%), gastroesophageal reflux (31.2%), bolus impaction (24.4%), and failure to thrive (10.5%). Approximately 70.3% had failed proton pump inhibitor treatment. The foods found to be causative of EoE by elimination and rechallenge were milk (42%), egg (21.5%), wheat/gluten (10.9%), and peanut (9.9%). Elimination diets were used exclusively in 154 of 410 (37.5%), topical steroids without elimination diets in 52 of 410 (12.6%), both diet and steroids in 183 of 410 (44.6%), systemic steroids in 22 of 410 (5.3%), and esophageal dilation in 7 of 410 (1.7%). Patient refusal, shortage of endoscopy time, and reluctance to perform multiple endoscopies per patient were noted as factors justifying deviation from guidelines. In this “real world” pediatric European cohort, milk and egg were the most common allergens triggering EoE. Although high-dose proton pump inhibitor trials have increased, attempted PPI treatment is not universal.

Published
2019
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46. Hepatitų etiologija vaikų amžiuje: Epštein-Baro virusinis hepatitas

Author

Urbonas, Vaidotas, Ališauskienė, Irena, Venclovienė, Rimantė, Firantienė, Regina, and Ėmužytė, Regina

Subjects
hemic and lymphatic diseases, Epstein-Barr virus, Hepatitis, Infectious mononucleosis, Children
Abstract

Epstein-Barr virus (EBV) causes the clinical syndrome commonly known as infectious mononucleosis (IM). Gastrointestinal manifestations are frequently present. These include abdominal pain, mild elevations of alanine (ALAT) and aspartate (ASAT) aminotransferases and hepatosplenomegaly. Less commonly hepatitis may occur. Severe hepatitis and liver failure have rarely been reported and are mostly related to immunodeficiency syndromes. This article presents two cases of EBV hepatitis in children and literature review of this disease.

Published
2012

48. Dažniausių vaikų virškinimo sistemos sutrikimų tyrimo ir gydymo aktualijos Lietuvoje per pastarąjį dešimtmetį

Author

Labanauskas, Liutauras, Kučinskienė, Rūta, Urbonas, Vaidotas, Rokaitė, Rūta, and Libikaitė, Neringa

Subjects
udc:616.33/.34-053.2, 616.33/.34-053.2 [udc], Gastrointestinal diseases, In infancy&childhood, Dermatitis, atopic, Helicobacter infections, Lithuania
Abstract

In the last decade, scientific studies in the field of children’s gastroenterology performed in Lithuania explored different problems: pathology of Helicobacter pylori infection and food allergy. Our studies Helirevealed that children with atopic dermatitis had gastrointestinal complaints (abdominal pain, diarrhea, distension and unstable stool, which appeared with the exacerbation of skin rash) more often as compared to nonallergic children of the control group. Abdominal pain in children with atopic dermatitis with local rash was more frequent and lasted longer than in control group children, whereas children with extended rash had stools more frequently. Gastrointestinal disorders in children with atopic dermatitis statistically significantly did not depend on the extent of skin rash and severity of atopic dermatitis. In our scientific research on the importance of H. pylori infection on children’s gastrointestinal system, children with chronic dyspepsia were examined. Endoscopy, rapid urease test, biopsies from antrum and corpus of stomach and their histological examination as well as serologic tests were done. According to the results obtained, we recommend to examine children with chronic dyspepsia in a complex way: not only endoscopic examination, but H. pylori diagnostic tests should be performed as well. Serologic test is not suitable for screening H. pylori infection in children. Considering this, we recommend to use no fewer than two different methods to diagnose this infection. The highest frequency of H. pylori infection was found in children with duodenal ulcer; histological changes in their gastric pylorus and corpus mucosa were greatest. More than half of children with nonulcer dyspepsia were infected with H. pylori [...].

Published
2008

49. Do Pediatricians Apply the 2009 NASPGHAN–ESPGHAN Guidelines for the Diagnosis and Management of Gastroesophageal Reflux After Being Trained?

Author

Quitadamo, Paolo, primary, Urbonas, Vaidotas, additional, Papadopoulou, Alexandra, additional, Roman, Enriqueta, additional, Pavkov, Danijela J., additional, Orel, Rok, additional, Dias, Jorge A., additional, Kostovski, Aco, additional, Miele, Erasmo, additional, Villani, Alberto, additional, and Staiano, Annamaria, additional

Published
2014
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50. European Pediatricians' Approach to Children With GER Symptoms

Author

Quitadamo, Paolo, primary, Papadopoulou, Alexandra, additional, Wenzl, Tobias, additional, Urbonas, Vaidotas, additional, Kneepkens, C.M. Frank, additional, Roman, Enriqueta, additional, Orel, Rok, additional, Pavkov, Danijela Jojkić, additional, Dias, Jorge Amil, additional, Vandenplas, Yvan, additional, Kostovski, Aco, additional, Miele, Erasmo, additional, Villani, Alberto, additional, and Staiano, Annamaria, additional

Published
2014
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