1. Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project
- Author
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Luciano Lippa, Raffaella Dell'Oro, M.L. Muiesan, Guido Grassi, Stefano Masi, Andrea Ungar, Ferruccio Galletti, P. Verdecchia, Enrico Agabiti Rosei, Agostino Virdis, Loreto Gesualdo, Massimo Cirillo, Francesca Mallamaci, Massimo Salvetti, Giulia Rivasi, B Bernardino, Massimo Volpe, Cristina Giannattasio, Paolo Palatini, Rita Facchetti, Carlo M. Barbagallo, Paolo Pauletto, Lanfranco D'Elia, Francesca Viazzi, Roberto Pontremoli, Arrigo Fg Cicero, Pietro Nazzaro, Claudio Ferri, Alessandro Maloberti, Giuliano Tocci, Gianfranco Parati, Valérie Tikhonoff, Michele Bombelli, Guido Iaccarino, Marcello Rattazzi, Edoardo Casiglia, Alberto Mazza, Claudio Borghi, Giovambattista Desideri, Pietro Cirillo, Fosca Quarti-Trevano, Maloberti, A, Giannattasio, C, Bombelli, M, Desideri, G, Cicero, Afg, Muiesan, Ml, Rosei, Ea, Salvetti, M, Ungar, A, Rivasi, G, Pontremoli, R, Viazzi, F, Facchetti, R, Ferri, C, Bernardino, B, Galletti, F, D’Elia, L, Palatini, P, Casiglia, E, Tikhonoff, V, Barbagallo, Cm, Verdecchia, P, Masi, S, Mallamaci, F, Cirillo, M, Rattazzi, M, Pauletto, P, Cirillo, P, Gesualdo, L, Mazza, A, Volpe, M, Tocci, G, Iaccarino, G, Nazzaro, P, Lippa, L, Parati, G, Dell’Oro, R, Quarti‑trevano, F, Grassi, G, Virdis, A, Borghi, C., Maloberti A, Giannattasio C, Bombelli M, Desideri G, Cicero AF, Muiesan ML, Rosei EA, Salvetti M, Ungar A, Rivasi G, Pontremoli R, Viazzi F, Facchetti R, Ferri C, Bernardino B, Galletti F, D'Elia L, Palatini P, Casiglia E, Tikhonoff V, Barbagallo CM, Verdecchia P, Masi S, Mallamaci F, Cirillo M, Rattazzi M, Pauletto P, Cirillo P, Gesualdo L, Mazza A, Volpe M, Tocci G, Iaccarino G, Nazzaro P, Lippa L, Parati G, Dell'Oro R, Quarti-Trevano F, Grassi G, Virdis A, Borghi C, Cicero, A, Muiesan, M, Rosei, E, D'Elia, L, Barbagallo, C, Dell'Oro, R, Quarti-Trevano, F, Borghi, C, and Maloberti A, Giannattasio C, Bombelli M, Desideri G, Cicero AFG, Muiesan ML, Rosei EA, Salvetti M, Ungar A, Rivasi G, Pontremoli R, Viazzi F, Facchetti R, Ferri C, Bernardino B, Galletti F, D'Elia L, Palatini P, Casiglia E, Tikhonoff V, Barbagallo CM, Verdecchia P, Masi S, Mallamaci F, Cirillo M, Rattazzi M, Pauletto P, Cirillo P, Gesualdo L, Mazza A, Volpe M, Tocci G, Iaccarino G, Nazzaro P, Lippa L, Parati G, Dell'Oro R, Quarti-Trevano F, Grassi G, Virdis A, Borghi C
- Subjects
0301 basic medicine ,Male ,Time Factors ,Disease ,Uric acid ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Uric Acid, Cardiovascular events, epidemiology ,Epidemiology ,Multicenter Studies as Topic ,Hyperuricemia ,Stroke ,Cardiovascular events ,Cardiovascular mortality ,URRAH ,Middle Aged ,Prognosis ,Observational Studies as Topic ,Italy ,Cardiovascular Diseases ,Research Design ,Female ,Cardiology and Cardiovascular Medicine ,Adult ,medicine.medical_specialty ,Uric acid · Cardiovascular mortality · Cardiovascular events · URRAH ,Context (language use) ,Cardiovascular event ,Risk Assessment ,03 medical and health sciences ,cardiovascular events ,cardiovascular mortality ,urrah ,uric acid ,Pharmacotherapy ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,business.industry ,medicine.disease ,030104 developmental biology ,chemistry ,Heart failure ,business ,030217 neurology & neurosurgery ,Biomarkers ,Uric Acid - Abstract
The latest European Guidelines of Arterial Hypertension have officially introduced uric acid evaluation among the cardiovascular risk factors that should be evaluated in order to stratify patient's risk. In fact, it has been extensively evaluated and demonstrated to be an independent predictor not only of all-cause and cardiovascular mortality, but also of myocardial infraction, stroke and heart failure. Despite the large number of studies on this topic, an important open question that still need to be answered is the identification of a cardiovascular uric acid cut-off value. The actual hyperuricemia cut-off (> 6 mg/dL in women and 7 mg/dL in men) is principally based on the saturation point of uric acid but previous evidence suggests that the negative impact of cardiovascular system could occur also at lower levels. In this context, the Working Group on uric acid and CV risk of the Italian Society of Hypertension has designed the Uric acid Right for heArt Health project. The primary objective of this project is to define the level of uricemia above which the independent risk of CV disease may increase in a significantly manner. In this review we will summarize the first results obtained and describe the further planned analysis.
- Published
- 2020