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2. Evaluation of the Therapeutical Effect of Matricaria Chamomilla Extract vs. Galantamine on Animal Model Memory and Behavior Using 18F-FDG PET/MRI

Author

Iacob, Roxana, primary, Palimariciuc, Matei, additional, Florea, Tudor, additional, Pricope, Cosmin Vasilica, additional, Uritu, Cristina Mariana, additional, Tamba, Bogdan Ionel, additional, Ionescu, Teodor Marian, additional, Stolniceanu, Cati Raluca, additional, Jalloul, Wael, additional, Dobrin, Romeo Petru, additional, Hritcu, Lucian, additional, Cioanca, Oana, additional, Hancianu, Monica, additional, Naum, Alexandru Gratian, additional, and Stefanescu, Cipriana, additional

Published
2024
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3. Exploring Cannabinoids with Enhanced Binding Affinity for Targeting the Expanded Endocannabinoid System: A Promising Therapeutic Strategy for Alzheimer's Disease Treatment.

Author

Stanciu, Gabriela Dumitrita, Ababei, Daniela-Carmen, Solcan, Carmen, Uritu, Cristina-Mariana, Craciun, Vlad-Constantin, Pricope, Cosmin-Vasilica, Szilagyi, Andrei, and Tamba, Bogdan-Ionel

Subjects
CANNABINOID receptors, ALZHEIMER'S disease, THERAPEUTICS, RECOGNITION (Psychology), CANNABINOIDS, LARGE-scale brain networks, GABA receptors
Abstract

Despite decades of rigorous research and numerous clinical trials, Alzheimer's disease (AD) stands as a notable healthcare challenge of this century, with effective therapeutic solutions remaining elusive. Recently, the endocannabinoid system (ECS) has emerged as an essential therapeutic target due to its regulatory role in different physiological processes, such as neuroprotection, modulation of inflammation, and synaptic plasticity. This aligns with previous research showing that cannabinoid receptor ligands have the potential to trigger the functional structure of neuronal and brain networks, potentially impacting memory processing. Therefore, our study aims to assess the effects of prolonged, intermittent exposure (over 90 days) to JWH-133 (0.2 mg/kg) and an EU-GMP certified Cannabis sativa L. (Cannabixir® Medium Flos, 2.5 mg/kg) on recognition memory, as well as their influence on brain metabolism and modulation of the expanded endocannabinoid system in APP/PS1 mice. Chronic therapy with cannabinoid receptor ligands resulted in reduced anxiety-like behavior and partially reversed the cognitive deficits. Additionally, a reduction was observed in both the number and size of Aβ plaque deposits, along with decreased cerebral glucose metabolism, as well as a decline in the expression of mTOR and CB2 receptors. Furthermore, the study revealed enlarged astrocytes and enhanced expression of M1 mAChR in mice subjected to cannabinoid treatment. Our findings highlight the pivotal involvement of the extended endocannabinoid system in cognitive decline and pathological aspects associated with AD, presenting essential preclinical evidence to support the continued exploration and assessment of cannabinoid receptor ligands for AD treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The Skin and Natural Cannabinoids–Topical and Transdermal Applications

Author

Filipiuc, Silviu-Iulian, primary, Neagu, Anca-Narcisa, additional, Uritu, Cristina Mariana, additional, Tamba, Bogdan-Ionel, additional, Filipiuc, Leontina-Elena, additional, Tudorancea, Ivona Maria, additional, Boca, Andreea Nicoleta, additional, Hâncu, Mădălina Florina, additional, Porumb, Vlad, additional, and Bild, Walther, additional

Published
2023
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5. The Roles of Imaging Biomarkers in the Management of Chronic Neuropathic Pain

Author

Pricope, Cosmin Vasilica, primary, Tamba, Bogdan Ionel, additional, Stanciu, Gabriela Dumitrita, additional, Cuciureanu, Magdalena, additional, Neagu, Anca Narcisa, additional, Creanga-Murariu, Ioana, additional, Dobrovat, Bogdan-Ionut, additional, Uritu, Cristina Mariana, additional, Filipiuc, Silviu Iulian, additional, Pricope, Bianca-Mariana, additional, and Alexa-Stratulat, Teodora, additional

Published
2022
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6. VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment

Author

Voicu, Geanina, primary, Rebleanu, Daniela, additional, Mocanu, Cristina Ana, additional, Tanko, Gabriela, additional, Droc, Ionel, additional, Uritu, Cristina Mariana, additional, Pinteala, Mariana, additional, Manduteanu, Ileana, additional, Simionescu, Maya, additional, and Calin, Manuela, additional

Published
2022
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9. Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells

Author

Voicu, Geanina, primary, Rebleanu, Daniela, additional, Constantinescu, Cristina Ana, additional, Fuior, Elena Valeria, additional, Ciortan, Letitia, additional, Droc, Ionel, additional, Uritu, Cristina Mariana, additional, Pinteala, Mariana, additional, Manduteanu, Ileana, additional, Simionescu, Maya, additional, and Calin, Manuela, additional

Published
2020
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