1. Characterization and impact of non-canonical WNT signaling on outcomes of urothelial carcinoma.
- Author
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Meagher, Margaret, Krause, Harris, Elliott, Andrew, Farrell, Alex, Antonarakis, Emmanuel, Bastos, Bruno, Heath, Elisabeth, Jamieson, Christina, Stewart, Tyler, Bagrodia, Aditya, Nabhan, Chadi, Oberley, Matt, McKay, Rana, and Salmasi, Amirali
- Subjects
FZD2 ,Non‐canonical ,ROR ,Urothelial carcinoma ,WNT signaling ,WNT5A ,Humans ,Wnt Proteins ,Carcinoma ,Transitional Cell ,Urinary Bladder Neoplasms ,Wnt Signaling Pathway ,Receptor Tyrosine Kinase-like Orphan Receptors ,Wnt-5a Protein - Abstract
BACKGROUND: Non-canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non-canonical WNT signaling through WNT5A, ROR1, ROR2, or FZD2 expression. METHODS: NextGen Sequencing of DNA (592 genes or WES)/RNA (WTS) was performed for 4125 UC tumors submitted to Caris Life Sciences. High and low expression of WNT5A, ROR1, ROR2, and FZD2 was defined as ≥ top and
- Published
- 2024