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BRACKGROUNDChildren are the population with the highest incidence of influenza and they are the main source of disease spread. However, there are little cases of influenza in neonates reported, so we do not have enough information regarding the management of the disease in this vulnerable population group.The aim of our study was to describe influenza cases upon neonatal patients admitted in a referral Neonatology Unit, during the last 7 years and to compare the management with other centers, described in the literature.METHODSWe conducted a descriptive, retrospective, longitudinal study, including consecutively admitted neonates with flu diagnosis, between 2009 and 2016, in a referal Division of Neonatology. Inclusion criteria: Term neonate younger than 1 month of life, and preterm neonate with a postconceptional age less than 44 weeks. The influenza diagnosis was defined as a patient with clinical signs and positive PCR for influenza virus. Epidemiological, clinical, diagnostic, prognostic and therapeutic variables were evaluated.Stadistics: Statistical analysis with SPSS 2.0 program. Kolmogorov u2013 Smirnov test is used to determine distribution of data. The qualitative variables were analyzed using the chi-square test, applying the student's t.RESULTS(Table) CONCLUSIONSIn conclusion, neonatal influenza infection is uncommon but can be a serious illness . The family epidemic environment is a very important risk factor for the transmission. Literature seems to recommend the administration of antiviral drugs in some cases, although there is no scientific evidence about this recommendation, and further studies are necessary.