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2. Integrating platelet reactivity in the age, creatinine and ejection fraction score to predict clinical outcomes following percutaneous coronary intervention in patients with chronic coronary syndrome: the PR-ACEF score

Author

Paolucci, Luca, Mangiacapra, Fabio, Viscusi, Michele Mattia, Sergio, Sara, Bressi, Edoardo, Colaiori, Iginio, Ricottini, Elisabetta, Cavallari, Ilaria, Nusca, Annunziata, Melfi, Rosetta, Ussia, Gian Paolo, and Grigioni, Francesco

Published
2024
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8. Impact of the COVID-19 Pandemic on Global TAVR Activity: The COVID-TAVI Study

Author

Armario, Xavier, Carron, Jennifer, Simpkin, Andrew J., Elhadi, Mohamed, Kennedy, Ciara, Abdel-Wahab, Mohamed, Bleiziffer, Sabine, Lefèvre, Thierry, Wolf, Alexander, Pilgrim, Thomas, Villablanca, Pedro A., Blackman, Daniel J., Van Mieghem, Nicolas M., Hengstenberg, Christian, Swaans, Martin J., Prendergast, Bernard D., Patterson, Tiffany, Barbanti, Marco, Webb, John G., Behan, Miles, Resar, Jon, Chen, Mao, Hildick-Smith, David, Spence, Mark S., Zweiker, David, Bagur, Rodrigo, Teles, Rui, Ribichini, Flavio L., Jagielak, Dariusz, Park, Duk-Woo, Kornowski, Ran, Wykrzykowska, Joanna J., Bunc, Matjaz, Estévez-Loureiro, Rodrigo, Poon, Karl, Götberg, Matthias, Jeger, Raban V., Ince, Hüseyin, Packer, Erik J.S., Angelillis, Marco, Nombela-Franco, Luis, Guo, Yingqiang, Savontaus, Mikko, Al-Moghairi, Abdulrahman M., Parasca, Catalina Andreea, Kliger, Chad, Roy, David, Molnár, Levente, Silva, Mariana, White, Jonathon, Yamamoto, Masanori, Carrilho-Ferreira, Pedro, Toggweiler, Stefan, Voudris, Vassileios, Ohno, Yohei, Rodrigues, Inês, Parma, Radosław, Ojeda, Soledad, Toutouzas, Kostas, Regueiro, Ander, Grygier, Marek, AlMerri, Khaled, Cruz-González, Ignacio, Fridrich, Viliam, de la Torre Hernández, José M., Noble, Stephane, Kala, Petr, Asmarats, Lluis, Kurt, Ibrahim Halil, Bosmans, Johan, Erglis, Martins, Casserly, Ivan, Iskandarani, Dounia, Bhindi, Ravinay, Kefer, Joelle, Yin, Wei-Hsian, Rosseel, Liesbeth, Kim, Hyo-Soo, O'Connor, Stephen, Hellig, Farrel, Sztejfman, Matias, Mendiz, Oscar, Pineda, Andres M., Seth, Ashok, Pllaha, Elton, de Brito, Fabio S., Jr., Bajoras, Vilhelmas, Balghith, Mohammed A., Lee, Michael, Eid-Lidt, Guering, Vandeloo, Bert, Vaz, Vinicius Daher, Alasnag, Mirvat, Ussia, Gian Paolo, Tay, Edgar, Mayol, Jorge, Gunasekaran, Sengottuvelu, Sardella, Gennaro, Buddhari, Wacin, Kao, Hsien-Li, Dager, Antonio, Tzikas, Apostolos, Gudmundsdottir, Ingibjörg J., Edris, Ahmad, Gutiérrez Jaikel, Luis Abel, Arias, Eduardo A., Al-Hijji, Mohammed, Ertürk, Mehmet, Conde-Vela, César, Boljević, Darko, Ferrero Guadagnoli, Adolfo, Hermlin, Toomas, ElGuindy, Ahmed M., Lima-Filho, Moysés de Oliveira, de Moura Santos, Luciano, Perez, Luis, Maluenda, Gabriel, Akyüz, Ali Rıza, Alhaddad, Imad A., Amin, Haitham, So, Chak-Yu, Al Nooryani, Arif A., Vaca, Carlos, Albistur, Juan, Nguyen, Quang Ngoc, Arzamendi, Dabit, Grube, Eberhard, Modine, Thomas, Tchétché, Didier, Hayashida, Kentaro, Latib, Azeem, Makkar, Raj R., Piazza, Nicolo, Søndergaard, Lars, McEvoy, John William, and Mylotte, Darren

Published
2024
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10. Financial Burden of Transcatheter Aortic Valve Implantation

Author

D'Errigo, Paola, Marcellusi, Andrea, Biancari, Fausto, Barbanti, Marco, Cerza, Francesco, Tarantini, Giuseppe, Ranucci, Marco, Ussia, Gian Paolo, Costa, Giuliano, Badoni, Gabriella, Fraccaro, Chiara, Meucci, Francesco, Baglio, Giovanni, Seccareccia, Fulvia, Tamburino, Corrado, and Rosato, Stefano

Published
2023
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13. The safety of transesophageal echocardiography to guide transcatheter tricuspid valve edge‐to‐edge repair

Author

Cammalleri, Valeria, primary, De Luca, Valeria Maria, additional, Antonelli, Giorgio, additional, Piscione, Maria Grazia, additional, Gaudio, Dario, additional, Carpenito, Myriam, additional, Mega, Simona, additional, di Pumpo, Anna Laura, additional, Carassiti, Massimiliano, additional, Grigioni, Francesco, additional, and Ussia, Gian Paolo, additional

Published
2024
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20. The Spectrum of Coronary Artery Disease in Elite Endurance Athletes—A Long-Standing Debate: State-of-the-Art Review.

Author

Celeski, Mihail, Di Gioia, Giuseppe, Nusca, Annunziata, Segreti, Andrea, Squeo, Maria Rosaria, Lemme, Erika, Mango, Federica, Ferrera, Armando, Ussia, Gian Paolo, and Grigioni, Francesco

Subjects
CORONARY artery disease, CORONARY artery calcification, ENDURANCE athletes, ENDURANCE sports, CARDIAC arrest
Abstract

Physical activity is recommended for the prevention of primary and secondary cardiovascular (CV) disease as it is linked to a number of health benefits, especially CV. However, recent research suggests that high-volume, long-term endurance exercise may hasten rather than slow the coronary atherosclerosis progression. This contentious theory has generated a great discussion and is still a major source of doubt when it comes to the clinical treatment of coronary artery disease (CAD) in athletes. CAD is the primary cause of sudden cardiac death in athletes over 35 years. Thus, recent studies evaluated the prevalence of CAD in athletes and its clinical and prognostic implications. Indeed, many studies have shown a relationship between endurance sports and higher volumes of coronary calcified plaque as determined by computed tomography. However, the precise pathogenetic substrate for the existence of an increased coronary calcification burden among endurance athletes remains unclear. Moreover, the idea that coronary plaques in elite athletes present a benign morphology has been cast into doubt by some recent studies showing potential association with adverse cardiovascular events. This review aims to analyze the association between physical activity and CAD, explaining possible underlying mechanisms of atherosclerotic progression and non-ischemic coronary lesions, focusing primarily on clinical and prognostic implications, multimodal evaluation, and management of CAD in endurance athletes. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Periprocedural myocardial infarction after percutaneous coronary intervention and long-term mortality: a meta-analysis.

Author

Paolucci, Luca, Mangiacapra, Fabio, Sergio, Sara, Nusca, Annunziata, Briguori, Carlo, Barbato, Emanuele, Ussia, Gian Paolo, and Grigioni, Francesco

Subjects
PERCUTANEOUS coronary intervention, MYOCARDIAL infarction, MYOCARDIAL ischemia, CORONARY artery disease, PROGNOSIS
Abstract

Background and Aims Conflicting data are available regarding the association between periprocedural myocardial infarction (PMI) and mortality following percutaneous coronary intervention. The purpose of this study was to evaluate the incidence and prognostic implication of PMI according to the Universal Definition of Myocardial Infarction (UDMI), the Academic Research Consortium (ARC)-2 definition, and the Society for Cardiovascular Angiography and Interventions (SCAI) definition. Methods Studies reporting adjusted effect estimates were systematically searched. The primary outcome was all-cause death, while cardiac death was included as a secondary outcome. Studies defining PMI according to biomarker elevation without further evidence of myocardial ischaemia ('ancillary criteria') were included and reported as 'definition-like'. Data were pooled in a random-effect model. Results A total of 19 studies and 109 568 patients were included. The incidence of PMI was progressively lower across the UDMI, ARC-2, and SCAI definitions. All PMI definitions were independently associated with all-cause mortality [UDMI: hazard ratio (HR) 1.61, 95% confidence interval (CI) 1.32–1.97; I 2 34%; ARC-2: HR 2.07, 95% CI 1.40–3.08, I 2 0%; SCAI: HR 3.24, 95% CI 2.36–4.44, I 2 78%]. Including ancillary criteria in the PMI definitions were associated with an increased prognostic performance in the UDMI but not in the SCAI definition. Data were consistent after evaluation of major sources of heterogeneity. Conclusions All currently available international definitions of PMI are associated with an increased risk of all-cause death after percutaneous coronary intervention. The magnitude of this latter association varies according to the sensitivity and prognostic relevance of each definition. [ABSTRACT FROM AUTHOR]

Published
2024
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24. 6 Months’ Follow-Up of the First-in-Man Implantation of a Novel Tricuspid Flow Optimizer

Author

Ussia, Gian Paolo, primary, Mangieri, Antonio, additional, Cammalleri, Valeria, additional, Sarkar, Kunal, additional, Regazzoli, Damiano, additional, Cozzi, Ottavia, additional, Gitto, Mauro, additional, Francone, Marco, additional, Fumero, Andrea, additional, Torracca, Lucia, additional, Bragato, Renato M., additional, Civilini, Efrem, additional, Reimers, Bernhard, additional, and Colombo, Antonio, additional

Published
2024
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25. Coronary Chronic Total Occlusion Revascularization: When, Who and How?

Author

Ricottini, Elisabetta, primary, Coletti, Federica, additional, Nusca, Annunziata, additional, Cocco, Nino, additional, Corlianò, Andrea, additional, Appetecchia, Alessandro, additional, Melfi, Rosetta, additional, Mangiacapra, Fabio, additional, Gallo, Paolo, additional, Rinaldi, Raffaele, additional, Grigioni, Francesco, additional, and Ussia, Gian Paolo, additional

Published
2024
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26. Eosinophilic Myocarditis: From Bench to Bedside

Author

Piccirillo, Francesco, primary, Mastroberardino, Sara, additional, Nafisio, Vincenzo, additional, Fiorentino, Matteo, additional, Segreti, Andrea, additional, Nusca, Annunziata, additional, Ussia, Gian Paolo, additional, and Grigioni, Francesco, additional

Published
2024
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28. Usefulness of Adding Pre-procedural Glycemia to the Mehran Score to Enhance Its Ability to Predict Contrast-induced Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention Development and Validation of a Predictive Model

Author

Nusca, Annunziata, Mangiacapra, Fabio, Sticchi, Alessandro, Polizzi, Giovanni, D'Acunto, Giulia, Ricottini, Elisabetta, Melfi, Rosetta, Gallo, Paolo, Miglionico, Marco, Giannone, Sara, Ussia, Gian Paolo, and Grigioni, Francesco

Published
2021
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30. Long Stent Implantation on the Left Anterior Descending Coronary Artery at a Follow-Up of More Than Five Years

Author

Sticchi, Alessandro, Tatali, Concetta, Ferraro, Massimo, Khokhar, Arif A., Scoccia, Alessandra, Cereda, Alberto, Toselli, Marco, Gallo, Francesco, Laricchia, Alessandra, Mangieri, Antonio, Grigioni, Francesco, Ussia, Gian Paolo, Giannini, Francesco, Colombo, Antonio, Sticchi, Alessandro, Tatali, Concetta, Ferraro, Massimo, Khokhar, Arif A., Scoccia, Alessandra, Cereda, Alberto, Toselli, Marco, Gallo, Francesco, Laricchia, Alessandra, Mangieri, Antonio, Grigioni, Francesco, Ussia, Gian Paolo, Giannini, Francesco, and Colombo, Antonio

Abstract

Background: Stent implantation represents the standard of care in coronary intervention. While a short stent implanted on a focal lesion located on the left anterior descending artery (LAD) seems a reasonable alternative to an internal mammary implant, the same for long stents is still debated. Methods: We reported the long-term data of 531 consecutive patients who underwent Percutaneous Coronary Intervention (PCI) with long stents in two highly specialized centres. The main inclusion criteria were the implantation of stents longer than 30 mm on the LAD and a minimum follow-up (FU) of five years. The primary endpoint was mortality, and the secondary endpoints were any myocardial infarction (MI), target vessel and lesion revascularization (TVR and TLR, respectively), and stent thrombosis (ST) observed as definite, probable, or possible. Results: In this selected population with characteristics of complex PCI (99.1%), the long-term follow-up (mean 92.18 ± 35.5 months) estimates of all-cause death, cardiovascular death, and any myocardial infarction were 18.3%, 10.5%, and 9.3%, respectively. Both all-cause and cardiovascular deaths are significantly associated with three-vessel disease (HR 6.8; confidence of interval (CI) 95% 3.844–11.934; p < 0.001, and HR 4.7; CI 95% 2.265–9.835; p < 0.001, respectively). Target lesion (TLR) and target vessel revascularization (TVR) are associated with the presence of three-lesion disease on the LAD (HR 3.4; CI 95% 1.984–5.781; p < 0.001; HR 3.9 CI 95% 2.323–6.442; p < 0.001, respectively). Re-PCI for any cause occurred in 31.5% of patients and shows an increased risk for three-lesion stenting (HR 4.3; CI 95% 2.873–6.376; p < 0.001) and the treatment of bifurcation with two stents (HR 1.6; 95% CI 1.051–2.414; p = 0.028). Stent thrombosis rate at the 5-year FU was 4.4% (1.3% definite; 0.9% probable; 2.1% possible), including a 1.7% rate of very-late thrombosis.

Published
2024

31. Natural History of Coronary Atherosclerosis in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: The Role of Quantitative Flow Ratio.

Author

Colaiori, Iginio, Paolucci, Luca, Mangiacapra, Fabio, Barbato, Emanuele, Ussia, Gian Paolo, Grigioni, Francesco, Demola, Pierluigi, Vitolo, Marco, Benatti, Giorgio, Vignali, Luigi, Gabbieri, Davide, Magnavacchi, Paolo, Sgura, Fabio Alfredo, Boriani, Giuseppe, and Guiducci, Vincenzo

Abstract

BACKGROUND: The prognostic impact of functionally significant coronary artery disease, as assessed with quantitative flow ratio (QFR), in patients with severe aortic stenosis treated with transcatheter aortic valve replacement is unknown. METHODS: This is a retrospective study with blind analysis of angiographic data, enrolling consecutive patients with severe aortic stenosis treated with transcatheter aortic valve replacement at 4 Italian centers. None of the patients enrolled received pre-transcatheter aortic valve replacement or concomitant coronary revascularization, either for the absence of significant coronary stenoses or by clinical decision. Visual estimation of diameter stenosis and QFR analysis were performed in all coronary arteries. The end point was all-cause mortality at a 3-year follow-up. RESULTS: A total of 318 patients were enrolled. At visual estimation, 140 patients (44%) presented a diameter stenosis ≥50% in at least 1 coronary artery, whereas 78 patients (24.5%) had at least 1 vessel with QFR <0.80 and, therefore, included in the positive QFR group. Overall, 69 (21.7%) patients died during the follow-up. In the Kaplan-Meier analysis, patients with positive QFR experienced significantly higher rates of death during follow-up compared with those without (51.1% versus 12.1%; P<0.001), whereas no significant difference was evident in terms of death between patients with or without significant coronary artery disease according to angiographic evaluation (24.3% versus 19.7%; P=0.244). In a multivariate regression model, positive QFR was an independent predictor of all-cause death during follow-up (hazard ratio, 5.31 [95% CI, 3.21-8.76]). CONCLUSIONS: Coronary QFR can predict mortality in patients with severe aortic stenosis treated with transcatheter aortic valve replacement without revascularization. [ABSTRACT FROM AUTHOR]

Published
2024
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32. The Other Side of the Coin: Transesophageal Echocardiography Complications following Cardiac Surgery and Transcatheter Structural Heart Interventions.

Author

De Luca, Valeria Maria, Cammalleri, Valeria, Antonelli, Giorgio, Bombace, Sara, Ruf, Tobias Friedrich, Gößler, Theresa Ann Maria, Lurz, Philipp, von Bardeleben, Ralph Stephan, Grigioni, Francesco, and Ussia, Gian Paolo

Subjects
TRICUSPID valve insufficiency, TRANSESOPHAGEAL echocardiography, SURGICAL complications, CARDIAC surgery, MITRAL valve insufficiency
Abstract

Transesophageal echocardiography (TEE) is widely used in cardiac surgery and interventional cardiology and is often an indispensable tool, giving supportive anatomical understanding and smooth guidance in both settings. Despite it being considered safe, fatal complications can commonly occur after a TEE examination in cardiac surgery operating rooms and catheterization laboratories. Currently, there is a lack of awareness of the scale of the problem, as there are only small amounts of data available, mainly derived from the surgical literature. This review summarizes the main predisposing factors for TEE-associated complications (classified as patient and procedure-related) and the main preventive strategies. We aim to apply preventive strategies more broadly, especially to patients at high risk of developing TEE-related serious adverse events. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Takotsubo Syndrome and Coronary Artery Disease: Which Came First—The Chicken or the Egg?

Author

Celeski, Mihail, primary, Nusca, Annunziata, additional, De Luca, Valeria Maria, additional, Antonelli, Giorgio, additional, Cammalleri, Valeria, additional, Melfi, Rosetta, additional, Mangiacapra, Fabio, additional, Ricottini, Elisabetta, additional, Gallo, Paolo, additional, Cocco, Nino, additional, Rinaldi, Raffaele, additional, Grigioni, Francesco, additional, and Ussia, Gian Paolo, additional

Published
2024
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38. Valve-in-Valve Implantation Using the ACURATE Neo in Degenerated Aortic Bioprostheses: An International Multicenter Analysis

Author

Holzamer, Andreas, Kim, Won-Keun, Rück, Andreas, Sathananthan, Janarthanan, Keller, Lukas, Cosma, Joseph, Bauer, Timm, Nef, Holger, Amat-Santos, Ignacio J., Brinkert, Miriam, Husser, Oliver, Pellegrini, Costanza, Schofer, Joachim, Nerla, Roberto, Montorfano, Matteo, Giannini, Francesco, Stella, Pieter, Kuwata, Shingo, Hilker, Michael, Castriota, Fausto, Ussia, Gian Paolo, Webb, John G., Nietlispach, Fabian, and Toggweiler, Stefan

Published
2019
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42. Incretins-Based Therapies and Their Cardiovascular Effects: New Game-Changers for the Management of Patients with Diabetes and Cardiovascular Disease

Author

Bernardini, Federico, primary, Nusca, Annunziata, additional, Coletti, Federica, additional, La Porta, Ylenia, additional, Piscione, Mariagrazia, additional, Vespasiano, Francesca, additional, Mangiacapra, Fabio, additional, Ricottini, Elisabetta, additional, Melfi, Rosetta, additional, Cavallari, Ilaria, additional, Ussia, Gian Paolo, additional, and Grigioni, Francesco, additional

Published
2023
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45. Mitral and Tricuspid Valve Disease in Athletes

Author

Segreti, Andrea, primary, Celeski, Mihail, additional, Monticelli, Luigi Maria, additional, Perillo, Alfonso, additional, Crispino, Simone Pasquale, additional, Di Gioia, Giuseppe, additional, Cammalleri, Valeria, additional, Fossati, Chiara, additional, Mega, Simona, additional, Papalia, Rocco, additional, Pigozzi, Fabio, additional, Ussia, Gian Paolo, additional, and Grigioni, Francesco, additional

Published
2023
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46. Functional Mitral and Tricuspid Regurgitation across the Whole Spectrum of Left Ventricular Ejection Fraction: Recognizing the Elephant in the Room of Heart Failure

Author

Cammalleri, Valeria, primary, Antonelli, Giorgio, additional, De Luca, Valeria Maria, additional, Carpenito, Myriam, additional, Nusca, Annunziata, additional, Bono, Maria Caterina, additional, Mega, Simona, additional, Ussia, Gian Paolo, additional, and Grigioni, Francesco, additional

Published
2023
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47. Watchful surgery in asymptomatic mitral valve prolapse

Author

Carpenito, Myriam, primary, Gelfusa, Martina, additional, Mega, Simona, additional, Cammalleri, Valeria, additional, Benfari, Giovanni, additional, De Stefano, Domenico, additional, Ussia, Gian Paolo, additional, Tribouilloy, Christophe, additional, Enriquez-Sarano, Maurice, additional, and Grigioni, Francesco, additional

Published
2023
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49. Relationship Between the Completeness of Revascularization and Myocardial Injury in Patients Treated With Percutaneous Coronary Intervention

Author

Paolucci, Luca, primary, Mangiacapra, Fabio, additional, Viscusi, Michele Mattia, additional, Ungaro, Simone, additional, Cocchia, Francesca, additional, Piccirillo, Francesco, additional, Nusca, Annunziata, additional, Melfi, Rosetta, additional, Ricottini, Elisabetta, additional, Gallo, Paolo, additional, Cocco, Nino, additional, Rinaldi, Raffaele, additional, Ussia, Gian Paolo, additional, and Grigioni, Francesco, additional

Published
2023
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