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2. Development of an umbilical cord blood transplantation–specific nonrelapse mortality risk assessment score

Author

Okada, Yosuke, Usui, Yoshiaki, Hayashi, Hiromi, Nishikubo, Masashi, Toubai, Tomomi, Uchida, Naoyuki, Tanaka, Masatsugu, Onizuka, Makoto, Takahashi, Satoshi, Doki, Noriko, Uehara, Yasufumi, Maruyama, Yumiko, Ishiwata, Kazuya, Kawakita, Toshiro, Sawa, Masashi, Eto, Tetsuya, Ishimaru, Fumihiko, Kato, Koji, Fukuda, Takahiro, Atsuta, Yoshiko, Kanda, Junya, Yakushijin, Kimikazu, and Nakasone, Hideki

Published
2024
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4. Fludarabine plus reduced-intensity busulfan versus fludarabine plus myeloablative busulfan in patients with non-Hodgkin lymphoma undergoing allogeneic hematopoietic cell transplantation

Author

Kamijo, Kimimori, Shimomura, Yoshimitsu, Shinohara, Akihito, Mizuno, Shohei, Kanaya, Minoru, Usui, Yoshiaki, Kim, Sung-Won, Ara, Takahide, Mizuno, Ishikazu, Kuriyama, Takuro, Nakazawa, Hideyuki, Matsuoka, Ken-ichi, Kusumoto, Shigeru, Maseki, Nobuo, Yamaguchi, Masaki, Ashida, Takashi, Onizuka, Makoto, Fukuda, Takahiro, Atsuta, Yoshiko, and Kondo, Eisei

Published
2023
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5. Autologous or allogeneic hematopoietic cell transplantation for relapsed or refractory PTCL-NOS or AITL

Author

Kameda, Kazuaki, Kako, Shinichi, Kim, Sung-Won, Usui, Yoshiaki, Kato, Koji, Fukuda, Takahiro, Uchida, Naoyuki, Kobayashi, Hikaru, Wakayama, Toshio, Sakaida, Emiko, Yano, Shingo, Imada, Kazunori, Nara, Miho, Ikeda, Takashi, Fuchida, Shin-ichi, Ishikawa, Jun, Sugahara, Hiroyuki, Kanda, Junya, Kimura, Takafumi, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Kondo, Eisei

Published
2022
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6. Possible prognostic impact of WT1 mRNA expression at day + 30 after haploidentical peripheral blood stem cell transplantation with posttransplant cyclophosphamide for patients with myeloid neoplasm: a multicenter study from the Okayama Hematological Study Group

Author

Kitamura, Wataru, Fujii, Nobuharu, Nawa, Yuichiro, Fujishita, Keigo, Sugiura, Hiroyuki, Yoshioka, Takanori, Fujiwara, Yuki, Usui, Yoshiaki, Fujii, Keiko, Fujiwara, Hideaki, Asada, Noboru, Nishimori, Hisakazu, Matsuoka, Ken-ichi, and Maeda, Yoshinobu

Published
2022
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7. Development of the Umbilical Cord Blood Transplantation-Specific Non-Relapse Mortality Risk Assessment Score: A Study from the Donor/Source and Transplant Complication Working Groups of Jstct

Author

Okada, Yosuke, primary, Usui, Yoshiaki, additional, Hayashi, Hiromi, additional, Nishikubo, Masashi, additional, Toubai, Tomomi, additional, Uchida, Naoyuki, additional, Tanaka, Masatsugu, additional, Onizuka, Makoto, additional, Takahashi, Satoshi, additional, Doki, Noriko, additional, Uehara, Yasufumi, additional, Maruyama, Yumiko, additional, Ishiwata, Kazuya, additional, Kawakita, Toshiro, additional, Sawa, Masashi, additional, Eto, Tetsuya, additional, Ishimaru, Fumihiko, additional, Kato, Koji, additional, Fukuda, Takahiro, additional, Atsuta, Yoshiko, additional, Kanda, Junya, additional, Yakushijin, Kimikazu, additional, and Nakasone, Hideki, additional

Published
2024
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13. Data from Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis

Author

Koyanagi, Yuriko N., primary, Suzuki, Etsuji, primary, Imoto, Issei, primary, Kasugai, Yumiko, primary, Oze, Isao, primary, Ugai, Tomotaka, primary, Iwase, Madoka, primary, Usui, Yoshiaki, primary, Kawakatsu, Yukino, primary, Sawabe, Michi, primary, Hirayama, Yutaka, primary, Tanaka, Tsutomu, primary, Abe, Tetsuya, primary, Ito, Seiji, primary, Komori, Koji, primary, Hanai, Nobuhiro, primary, Tajika, Masahiro, primary, Shimizu, Yasuhiro, primary, Niwa, Yasumasa, primary, Ito, Hidemi, primary, and Matsuo, Keitaro, primary

Published
2023
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14. Supplementary Table S1-9 from Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis

Author

Koyanagi, Yuriko N., primary, Suzuki, Etsuji, primary, Imoto, Issei, primary, Kasugai, Yumiko, primary, Oze, Isao, primary, Ugai, Tomotaka, primary, Iwase, Madoka, primary, Usui, Yoshiaki, primary, Kawakatsu, Yukino, primary, Sawabe, Michi, primary, Hirayama, Yutaka, primary, Tanaka, Tsutomu, primary, Abe, Tetsuya, primary, Ito, Seiji, primary, Komori, Koji, primary, Hanai, Nobuhiro, primary, Tajika, Masahiro, primary, Shimizu, Yasuhiro, primary, Niwa, Yasumasa, primary, Ito, Hidemi, primary, and Matsuo, Keitaro, primary

Published
2023
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15. Supplementary Figure S1 from Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis

Author

Koyanagi, Yuriko N., primary, Suzuki, Etsuji, primary, Imoto, Issei, primary, Kasugai, Yumiko, primary, Oze, Isao, primary, Ugai, Tomotaka, primary, Iwase, Madoka, primary, Usui, Yoshiaki, primary, Kawakatsu, Yukino, primary, Sawabe, Michi, primary, Hirayama, Yutaka, primary, Tanaka, Tsutomu, primary, Abe, Tetsuya, primary, Ito, Seiji, primary, Komori, Koji, primary, Hanai, Nobuhiro, primary, Tajika, Masahiro, primary, Shimizu, Yasuhiro, primary, Niwa, Yasumasa, primary, Ito, Hidemi, primary, and Matsuo, Keitaro, primary

Published
2023
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16. Helicobacter pylori , Homologous-Recombination Genes, and Gastric Cancer

Author

Usui, Yoshiaki, primary, Taniyama, Yukari, additional, Endo, Mikiko, additional, Koyanagi, Yuriko N., additional, Kasugai, Yumiko, additional, Oze, Isao, additional, Ito, Hidemi, additional, Imoto, Issei, additional, Tanaka, Tsutomu, additional, Tajika, Masahiro, additional, Niwa, Yasumasa, additional, Iwasaki, Yusuke, additional, Aoi, Tomomi, additional, Hakozaki, Nozomi, additional, Takata, Sadaaki, additional, Suzuki, Kunihiko, additional, Terao, Chikashi, additional, Hatakeyama, Masanori, additional, Hirata, Makoto, additional, Sugano, Kokichi, additional, Yoshida, Teruhiko, additional, Kamatani, Yoichiro, additional, Nakagawa, Hidewaki, additional, Matsuda, Koichi, additional, Murakami, Yoshinori, additional, Spurdle, Amanda B., additional, Matsuo, Keitaro, additional, and Momozawa, Yukihide, additional

Published
2023
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18. Association between early corticosteroid administration and long-term survival in non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation

Author

Kambara, Yui, primary, Fujii, Nobuharu, additional, Usui, Yoshiaki, additional, Yamamoto, Akira, additional, Higo, Hisao, additional, Fujiwara, Hideaki, additional, Asada, Noboru, additional, Ennishi, Daisuke, additional, Nishimori, Hisakazu, additional, Fujii, Keiko, additional, Matsuoka, Ken-ichi, additional, and Maeda, Yoshinobu, additional

Published
2022
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19. Association between germline pathogenic variants in cancer‐predisposing genes and lymphoma risk

Author

Usui, Yoshiaki, primary, Iwasaki, Yusuke, additional, Matsuo, Keitaro, additional, Endo, Mikiko, additional, Kamatani, Yoichiro, additional, Hirata, Makoto, additional, Sugano, Kokichi, additional, Yoshida, Teruhiko, additional, Matsuda, Koichi, additional, Murakami, Yoshinori, additional, Maeda, Yoshinobu, additional, Nakagawa, Hidewaki, additional, and Momozawa, Yukihide, additional

Published
2022
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20. Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants

Author

Momozawa, Yukihide, primary, Sasai, Rumi, additional, Usui, Yoshiaki, additional, Shiraishi, Kouya, additional, Iwasaki, Yusuke, additional, Taniyama, Yukari, additional, Parsons, Michael T., additional, Mizukami, Keijiro, additional, Sekine, Yuya, additional, Hirata, Makoto, additional, Kamatani, Yoichiro, additional, Endo, Mikiko, additional, Inai, Chihiro, additional, Takata, Sadaaki, additional, Ito, Hidemi, additional, Kohno, Takashi, additional, Matsuda, Koichi, additional, Nakamura, Seigo, additional, Sugano, Kokichi, additional, Yoshida, Teruhiko, additional, Nakagawa, Hidewaki, additional, Matsuo, Keitaro, additional, Murakami, Yoshinori, additional, Spurdle, Amanda B., additional, and Kubo, Michiaki, additional

Published
2022
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21. Association Between PSCA Variants and Duodenal Ulcer Risk

Author

Usui, Yoshiaki, Matsuo, Keitaro, Oze, Isao, Ugai, Tomotaka, Koyanagi, Yuriko, Maeda, Yoshinobu, Ito, Hidemi, Hishida, Asahi, Takeuchi, Kenji, Tamura, Takashi, Tsukamoto, Mineko, Kadomatsu, Yuka, Hara, Megumi, Nishida, Yuichiro, Shimoshikiryo, Ippei, Takezaki, Toshiro, Ozaki, Etsuko, Matsui, Daisuke, Watanabe, Isao, Suzuki, Sadao, Watanabe, Miki, Nakagawa-Senda, Hiroko, Mikami, Haruo, Nakamura, Yohko, Arisawa, Kokichi, Uemura, Hirokazu, Kuriki, Kiyonori, Takashima, Naoyuki, Kadota, Aya, Ikezaki, Hiroaki, Murata, Masayuki, Nakatochi, Masahiro, Momozawa, Yukihide, Kubo, Michiaki, and Wakai, Kenji

Subjects
Adult, Genetic Markers, Male, Genotype, GPI-Linked Proteins, Polymorphism, Single Nucleotide, Helicobacter Infections, Cohort Studies, Antigens, Neoplasm, Risk Factors, Genetics, Humans, cross-sectional study, Genetic Predisposition to Disease, lcsh:R5-920, Helicobacter pylori, DNA, Neoplasm, Middle Aged, psca, japan, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Cross-Sectional Studies, Immunoglobulin G, Original Article, Female, duodenal ulcer, lcsh:Medicine (General)
Abstract

Background: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population. Methods: Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU. Results: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18–1.51; P = 2.28 × 10−6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs. Conclusions: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.

Published
2021

23. Correction to: Low-intensity cigarette smoking and mortality risks: a pooled analysis of prospective cohort studies in Japan

Author

Inoue-Choi, Maki, primary, Freedman, Neal D, additional, Saito, Eiko, additional, Tanaka, Shiori, additional, Hirabayashi, Mayo, additional, Sawada, Norie, additional, Tsugane, Shoichiro, additional, Usui, Yoshiaki, additional, Ito, Hidemi, additional, Wang, Chaochen, additional, Tamakoshi, Akiko, additional, Takeuchi, Taro, additional, Kitamura, Yuri, additional, Utada, Mai, additional, Ozasa, Kotaro, additional, Sugawara, Yumi, additional, Tsuji, Ichiro, additional, Wada, Keiko, additional, Nagata, Chisato, additional, Shimazu, Taichi, additional, Mizoue, Tetsuya, additional, Matsuo, Keitaro, additional, Naito, Mariko, additional, Tanaka, Keitaro, additional, Katanoda, Kota, additional, and Inoue, Manami, additional

Published
2022
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25. Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer

Author

Usui, Yoshiaki, Matsuo, Keitaro, Oze, Isao, Ugai, Tomotaka, Koyanagi, Yuriko, Maeda, Yoshinobu, Ito, Hidemi, Hishida, Asahi, Takeuchi, Kenji, Tamura, Takashi, Tsukamoto, Mineko, Kadomatsu, Yuka, Hara, Megumi, Nishida, Yuichiro, Shimoshikiryo, Ippei, Takezaki, Toshiro, Ozaki, Etsuko, Matsui, Daisuke, Watanabe, Isao, Suzuki, Sadao, Watanabe, Miki, Nakagawa-Senda, Hiroko, Mikami, Haruo, Nakamura, Yohko, Arisawa, Kokichi, Uemura, Hirokazu, Kuriki, Kiyonori, Takashima, Naoyuki, Kadota, Aya, Ikezaki, Hiroaki, Murata, Masayuki, Nakatochi, Masahiro, Momozawa, Yukihide, Kubo, Michiaki, Wakai, Kenji, Usui, Yoshiaki, Matsuo, Keitaro, Oze, Isao, Ugai, Tomotaka, Koyanagi, Yuriko, Maeda, Yoshinobu, Ito, Hidemi, Hishida, Asahi, Takeuchi, Kenji, Tamura, Takashi, Tsukamoto, Mineko, Kadomatsu, Yuka, Hara, Megumi, Nishida, Yuichiro, Shimoshikiryo, Ippei, Takezaki, Toshiro, Ozaki, Etsuko, Matsui, Daisuke, Watanabe, Isao, Suzuki, Sadao, Watanabe, Miki, Nakagawa-Senda, Hiroko, Mikami, Haruo, Nakamura, Yohko, Arisawa, Kokichi, Uemura, Hirokazu, Kuriki, Kiyonori, Takashima, Naoyuki, Kadota, Aya, Ikezaki, Hiroaki, Murata, Masayuki, Nakatochi, Masahiro, Momozawa, Yukihide, Kubo, Michiaki, and Wakai, Kenji

Abstract

Background: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population. Methods: Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU. Results: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18–1.51; P = 2.28 × 10−6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs. Conclusions: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.

Published
2021

26. Low-intensity cigarette smoking and mortality risks: a pooled analysis of prospective cohort studies in Japan.

Author

Inoue-Choi, Maki, Freedman, Neal D, Saito, Eiko, Tanaka, Shiori, Hirabayashi, Mayo, Sawada, Norie, Tsugane, Shoichiro, Usui, Yoshiaki, Ito, Hidemi, Wang, Chaochen, Tamakoshi, Akiko, Takeuchi, Taro, Kitamura, Yuri, Utada, Mai, Ozasa, Kotaro, Sugawara, Yumi, Tsuji, Ichiro, Wada, Keiko, Nagata, Chisato, and Shimazu, Taichi

Subjects
RESEARCH, META-analysis, RESEARCH methodology, EVALUATION research, COMPARATIVE studies, RESEARCH funding, LONGITUDINAL method
Abstract

Background: Increasing proportions of smokers in Japan smoke <10 cigarettes per day (CPD). Yet, the health risks of low-intensity smoking in Asia are poorly understood.Methods: We performed a pooled analysis of 410 294 adults from nine population-based prospective cohort studies participating in the Japan Cohort Consortium. Cigarette-use data were collected at each study baseline in 1983-1994. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality were calculated using multivariable-adjusted Cox regression by CPD among current smokers and by age at cessation among former smokers, with never smokers as the referent group. Pooled HRs and CIs were computed using a random-effect model.Results: The smoking prevalence was 54.5% in men and 7.4% in women. About 15.5% of male and 50.4% of female current smokers smoked 1-10 CPD (low-intensity). Both male and female low-intensity smokers had higher all-cause mortality risks than never smokers. Risks were further higher with increasing CPD in a dose-response manner. HRs (95% CIs) were 1.27 (0.97-1.66), 1.45 (1.33-1.59) and 1.49 (1.38-1.62) for 1-2, 3-5 and 6-10 CPD, respectively, in men; 1.28 (1.01-1.62), 1.49 (1.34-1.66) and 1.68 (1.55-1.81) for 1-2, 3-5 and 6-10 CPD, respectively, in women. Similar associations were observed for smoking-related causes of death. Among former low-intensity smokers, younger age at cessation was associated with lower mortality risk.Conclusions: Smoking very low amounts was associated with increased mortality risks in Japan. All smokers should quit, even if they smoke very few CPD. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer

Author

Usui, Yoshiaki, primary, Matsuo, Keitaro, additional, Oze, Isao, additional, Ugai, Tomotaka, additional, Koyanagi, Yuriko, additional, Maeda, Yoshinobu, additional, Ito, Hidemi, additional, Hishida, Asahi, additional, Takeuchi, Kenji, additional, Tamura, Takashi, additional, Tsukamoto, Mineko, additional, Kadomatsu, Yuka, additional, Hara, Megumi, additional, Nishida, Yuichiro, additional, Shimoshikiryo, Ippei, additional, Takezaki, Toshiro, additional, Ozaki, Etsuko, additional, Matsui, Daisuke, additional, Watanabe, Isao, additional, Suzuki, Sadao, additional, Watanabe, Miki, additional, Nakagawa-Senda, Hiroko, additional, Mikami, Haruo, additional, Nakamura, Yohko, additional, Arisawa, Kokichi, additional, Uemura, Hirokazu, additional, Kuriki, Kiyonori, additional, Takashima, Naoyuki, additional, Kadota, Aya, additional, Ikezaki, Hiroaki, additional, Murata, Masayuki, additional, Nakatochi, Masahiro, additional, Momozawa, Yukihide, additional, Kubo, Michiaki, additional, and Wakai, Kenji, additional

Published
2021
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31. Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis

Author

Koyanagi, Yuriko N., primary, Suzuki, Etsuji, additional, Imoto, Issei, additional, Kasugai, Yumiko, additional, Oze, Isao, additional, Ugai, Tomotaka, additional, Iwase, Madoka, additional, Usui, Yoshiaki, additional, Kawakatsu, Yukino, additional, Sawabe, Michi, additional, Hirayama, Yutaka, additional, Tanaka, Tsutomu, additional, Abe, Tetsuya, additional, Ito, Seiji, additional, Komori, Koji, additional, Hanai, Nobuhiro, additional, Tajika, Masahiro, additional, Shimizu, Yasuhiro, additional, Niwa, Yasumasa, additional, Ito, Hidemi, additional, and Matsuo, Keitaro, additional

Published
2020
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33. N-terminal pro-brain natriuretic peptide reflects both left ventricular diastolic dysfunction and myeloma-related renal insufficiency and robustly predicts mortality in patients with symptomatic multiple myeloma

Author

Abe, Yoshiaki, primary, Kobayashi, Tetsuya, additional, Usui, Yoshiaki, additional, Narita, Kentaro, additional, Kobayashi, Hiroki, additional, Kitadate, Akihiro, additional, Miura, Daisuke, additional, Takeuchi, Masami, additional, and Matsue, Kosei, additional

Published
2019
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34. Impact of the combination of donor age and HLA disparity on the outcomes of unrelated bone marrow transplantation

Author

Seo, Sachiko, Usui, Yoshiaki, Matsuo, Keitaro, Atsuta, Yoshiko, Igarashi, Aiko, Fukuda, Takahiro, Ozawa, Yukiyasu, Katayama, Yuta, Yoshida, Shuro, Uchida, Naoyuki, Kondo, Tadakazu, Kako, Shinichi, Tsukada, Nobuhiro, Kato, Shunichi, Onizuka, Makoto, Ichinohe, Tatsuo, Kimura, Fumihiko, Kanda, Yoshinobu, Miyamura, Koichi, and Kanda, Junya

Abstract

Impact of donor age considering HLA disparity on hematopoietic cell transplantation (HCT) outcomes has not been fully evaluated. We evaluated 8486 patients who received unrelated bone marrow transplantation (UR-BMT) from 8/8 or 7/8 HLA-matched donors. Compared to 8/8 HLA-matched younger donors (<40 years), 8/8 HLA-matched older donors (subdistribution hazard ratio [SHR], 1.16; 95% CI, 0.97–1.38) and 7/8 HLA-matched younger donors (SHR, 1.33; 95% CI, 1.11–1.58) were associated with increased risk of grade III–IV acute graft-versus-host disease (aGVHD). 7/8 HLA-matched older donors had further increased risk (SHR, 2.00; 95% CI, 1.68–2.38) due to interaction between donor age and HLA disparity (pfor interaction = 0.038). Progression-free survival (PFS) after UR-BMT with 8/8 HLA-matched younger donors was comparable to that after UR-BMT with 8/8 HLA-matched older donors, whereas UR-BMT with 7/8 HLA-matched younger or older donors was significantly associated with lower PFS than UR-BMT with 8/8 HLA-matched younger donors (younger donor; HR, 1.12; 95% CI, 1.04–1.21, older donor; HR, 1.28; 95% CI, 1.17–1.40; pfor interaction = 0.079). In conclusion, adverse effect of increased donor age requires attention, especially in HLA-mismatched UR-BMT due to interaction between donor age and HLA disparity. Intensive aGVHD prophylaxis may be required to improve outcomes after HCT with mismatched older donors.

Published
2021
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35. Quantification of bone marrow plasma cell infiltration in multiple myeloma: Usefulness of bone marrow aspirate clot with CD138 immunohistochemistry

Author

Matsue, Kosei, Matsue, Yuya, Kumata, Kaoru, Usui, Yoshiaki, Suehara, Yasuhito, Fukumoto, Kota, Fujisawa, Manabu, Narita, Kentaro, and Takeuchi, Masami

Subjects
multiple myeloma, INVOLVEMENT, bone marrow biopsy, SYNDECAN-1, hemic and lymphatic diseases, flow cytometry, AGREEMENT, plasma cell quantification, CD 138 immunostaining, DIAGNOSIS, aspirate smear, NEOPLASMS
Abstract

Accurate quantification of plasma cells (PCs) in bone marrow (BM) is critical for diagnosis and assessment of treatment response in patients with multiple myeloma (MM). We compared the % of BM PC quantified by 250 cell differential count on May–Giemsa-stained BM smears, by counting 500 – 2500 cells in 2 – 5 representative microscopy fields in CD138-immunostained BM clot and biopsy sections, and CD38/CD45/CD138 gated BM PCs on flow cytometry (FCM) in 150 sets of BM samples from 120 patients. Percentages of PC were significantly correlated between BM biopsy and clot, and between smear and FCM (r = 0.96, 0.93, respectively). However, quantification by smear and FCM significantly underestimated the PC compared to biopsy or clot, and the degree of underestimation increased with blood dilution. FCM consistently showed lower % of PC compared to aspirate smears. Fifty-nine of 103 patients with M-protein level

Published
2017

41. Development of an umbilical cord blood transplantation-specific non-relapse mortality risk assessment score

Author

Okada, Yosuke, Usui, Yoshiaki, Hayashi, Hiromi, Nishikubo, Masashi, Toubai, Tomomi, Uchida, Naoyuki, Tanaka, Masatsugu, Onizuka, Makoto, Takahashi, Satoshi, Doki, Noriko, Uehara, Yasufumi, Maruyama, Yumiko, Ishiwata, Kazuya, Kawakita, Toshiro, Sawa, Masashi, Eto, Tetsuya, Ishimaru, Fumihiko, Kato, Koji, Fukuda, Takahiro, Atsuta, Yoshiko, Kanda, Junya, Yakushijin, Kimikazu, and Nakasone, Hideki

Abstract

●We developed the umbilical cord blood transplantation (UCBT)-specific non-relapse mortality (NRM) risk assessment (CoBRA) score.●The CoBRA score could predict the NRM risk as well as overall survival after UCBT.

Published
2024
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