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2. Correction: Chiangnoon et al. Antibacterial Hydrogel Sheet Dressings Composed of Poly(vinyl alcohol) and Silver Nanoparticles by Electron Beam Irradiation. Gels 2023, 9, 80

Author

Chiangnoon, Rattanakorn, primary, Karawak, Pennapa, additional, Eamsiri, Jarurattana, additional, Nuchdang, Sasikarn, additional, Thamrongsiripak, Nuatawan, additional, Neramitmansook, Naruemon, additional, Pummarin, Siwanut, additional, Pimton, Pimchanok, additional, Nilgumhang, Kewalee, additional, and Uttayarat, Pimpon, additional

Published
2023
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4. Antibacterial Hydrogel Sheet Dressings Composed of Poly(vinyl alcohol) and Silver Nanoparticles by Electron Beam Irradiation

Author

Chiangnoon, Rattanakorn, primary, Karawak, Pennapa, additional, Eamsiri, Jarurattana, additional, Nuchdang, Sasikarn, additional, Thamrongsiripak, Nuatawan, additional, Neramitmansook, Naruemon, additional, Pummarin, Siwanut, additional, Pimton, Pimchanok, additional, Nilgumhang, Kewalee, additional, and Uttayarat, Pimpon, additional

Published
2023
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5. Electron Beam Irradiation Cross-Linked Hydrogel Patches Loaded with Red Onion Peel Extract for Transdermal Drug Delivery: Formulation, Characterization, Cytocompatibility, and Skin Permeation

Author

Uttayarat, Pimpon, primary, Chiangnoon, Rattanakorn, additional, Thongnopkoon, Thanu, additional, Noiruksa, Kesinee, additional, Trakanrungsie, Jirachaya, additional, Phattanaphakdee, Wattanaporn, additional, Chittasupho, Chuda, additional, and Athikomkulchai, Sirivan, additional

Published
2023
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7. Quantification of histone H2AX phosphorylation in white blood cells induced by ex vivo gamma irradiation of whole blood by both flow cytometry and foci counting as a dose estimation in rapid triage

Author

Wanotayan, Rujira, primary, Wongsanit, Sarinya, additional, Boonsirichai, Kanokporn, additional, Sukapirom, Kasama, additional, Buppaungkul, Sakchai, additional, Charoenphun, Putthiporn, additional, Songprakhon, Pucharee, additional, Jangpatarapongsa, Kulachart, additional, and Uttayarat, Pimpon, additional

Published
2022
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12. Processing and Characterization of Antibacterial Hydrogel Sheet Dressings Composed of Poly(vinyl alcohol) and Silk Fibroin for Wound Healing Application.

Author

UTTAYARAT, Pimpon, CHIANGNOON, Rattanakorn, EAMSIRI, Jarurattana, and SENAWONGSE, Wongwit

Subjects
*HYDROGELS, *POLYVINYL alcohol, *SILK fibroin, *IRRADIATION, *PSEUDOMONAS aeruginosa
Abstract

Hydrogels are soft materials that contain high water content within their 3-dimensional structure. Such extremely hydrated environment allows hydrogels to recapitulate the structure of many native tissues inside the body. In biomedical application, hydrogels have been extensively used as biocompatible materials, drug delivery systems, and tissue-engineered scaffolds that can be designed to possess either permanent or slow-degradation properties. In this research, we applied gamma irradiation to develop transparent and conformal hydrogel sheets with sufficient mechanical strength from poly(vinyl alcohol) (PVA) and further modified the based PVA matrix with naturally-derived silk fibroin (SF) protein and silver nitrate (AgNO3) for wound healing purpose. The physical and mechanical properties of based PVA hydrogels formed at varied irradiation doses from 10 - 80 kGy were first characterized. The dose of 60 kGy was found to be optimal to process flexible and elastic PVA sheets with equilibrium degree of swelling of 1000%, gel fraction of 90%, and tensile strength of 19 kPa. To further enhance water absorption capacity, 10 - 40% (w/w) silk fibroin was added to the based PVA matrix. Based on water absorption and gel fraction data, hydrogel sheets with 8PVA:2SF formulation was selected for antibacterial test. Disc diffusion assay showed that the incorporation of 0.4 mM AgNO3 in 8PVA:2SF hydrogel sheets could inhibit the growth of Staphyllococcus aureus and Pseudomonas aeruginosa. These results demonstrated that a prototypic, antibacterial hydrogel sheet dressing composed of both synthetic and natural polymers could be developed within a single-step by gamma irradiation technique. [ABSTRACT FROM AUTHOR]

Published
2019

15. Diverse Biomedical Applications of Electrospun Scaffolds.

Author

Har-el, Yah-el, Frohberg, Michael E., Senel Ayaz, H. Gozde, Perets, Anat, Uttayarat, Pimpon, Gerstenhaber, Jonathan, and Lelkes, Peter I.

Abstract

In this presentation we will discuss strengths and weaknesses of electrospinning as a platform technology for a wide variety of biomedical applications, such as wound dressings, and vascular grafts as well as for creating complex 3-dimensional (3D) structures for tissue engineering. Based on the choice of natural or synthetic biopolymeric materials used and in conjunction with nano/micro-sized additives and crosslinkers, such as hydroxyapatite or genipin, complex electrospun structures can be tailored to emulate mechanical properties of various organs, ranging from neural tissue to bone. Examples for successfully electrospun biopolymers alone or in combinations with synthetic biomaterials, such as PLGA, include collagen, elastin and chitosan. Our laboratory has recently described the use of chitosan scaffolds for repairing critical-size defects in the cranial bone of mice with and without pre-seeding the scaffolds with mesenchymal stem cells1. Importantly, following mineralization and cross-linking, electrospun chitosan scaffolds emulated the mechanical properties of calvarial bone and were able to induce bone regeneration, even in the absence of stem cell seeding prior to implantation. As a weakness, the tight structure and small pore diameters of electrospun scaffolds usually obstruct cell penetration. We will discuss methods to overcome this shortcoming, e.g., by increasing the pore size using sacrificial polymers and or by creating composite blends with increased elasticity. As an alternative to using animal-derived biomaterials, we will describe recent studies utilizing plant derived compounds, such as soy protein, for generating electrospun bioactive wound dressings that are capable of improving the healing of full-thickness cutaneous wounds in rodent and porcine models2.3. Finally, we will discuss the use of synthetic elastomeric biomaterials, such as polyurethanes, in conjunction with innovative manufacturing technologies for electrospinning complex micropatterned vascular grafts4 that mimic the compliance of natural blood vessels or for creating anisotropic, textile- templated, scaffolds, that might be useful for cardiac repair5. [ABSTRACT FROM AUTHOR]

Published
2014

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