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11 results on '"Uzozie, Anuli C."'

9. PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

Author

Uzozie, Anuli C., primary, Ergin, Enes K., additional, Rolf, Nina, additional, Tsui, Janice, additional, Lorentzian, Amanda, additional, Weng, Samuel S., additional, Nierves, Lorenz, additional, Smith, Theodore G., additional, Lim, C. James, additional, Maxwell, Christopher A., additional, Reid, Gregor S.D., additional, and Lange, Philipp F., additional

Published
2019
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11. HUNTER: Sensitive Automated Characterization of Proteolytic Systems by N Termini Enrichment from Microscale Specimen.

Author

Uzozie AC, Tsui J, and Lange PF

Subjects
Peptide Hydrolases metabolism, Protein Processing, Post-Translational, Proteolysis, Proteome metabolism, Proteomics methods
Abstract

Proteolysis occurs at low frequency in the cellular environment. Protein N termini reveal essential mechanisms associated with cellular functions, and are useful indicators to track dysfunctional regulation of proteins and pathways in diseases. N terminomics has so far relied on labor-intensive methods, which require relatively large starting sample amounts rendering it ill-suited for high-throughput systems biology studies. Here, we describe protocols for the first scalable and automatable method for sensitive enrichment and identification of N termini from minute samples., (© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2022
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