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Fundamento El sindrome hipereosinofilo (SHE) es un grupo heterogeneo de procesos raros caracterizados por un aumento prominente y sostenido de eosinofilos en sangre y dano organico. Se deben excluir otras causas de hipereosinofilia. Avances recientes en biologia molecular y citogenetica han permitido caracterizar diferentes subtipos. Se describe un caso de la variedad linfoide. Paciente Varon filipino de 46 anos que consulta por lesiones cutaneas, fiebre, conjuntivitis, adenopatias y eosinofilia prominente. Resultados El estudio de poblaciones linfocitarias en sangre periferica revela una poblacion aberrante de linfocitos T (LT) CD3-CD4+ productora de interleucina 5 (IL-5). Se confirmo la clonalidad del TCR mediante PCR. Conclusiones La variedad linfoide del SHE esta caracterizada por una expansion clonal de LT no maligna que produce IL-5, de comportamiento indolente, pero que puede evolucionar a linfoma T periferico. Se describe el primer caso de variedad linfoide publicada en nuestro pais y se revisan las caracteristicas de esta variedad.

Hypereosinophilic syndromes (HSS) are a rare group of heterogeneous disorders characterized by prominent and persistent eosinophilia and organ dysfunction. Secondary causes of eosinophilia must be excluded. Recent advances in molecular biology and cytogenetics have permitted the characterization of different subsets of hypereosinophilic syndrome. We describe a patient with the lymphocytic variant.A 46-year old male Philippine patient presented skin lesions, fever, red eyes, enlarged lymph nodes and marked eosinophilia.Lymphocytic phenotyping by flow cytometry analysis was performed on peripheral blood and an aberrant population of T lymphocytes CD3-CD4+ producing interleukin 5 was found. TCR gene rearrangement using PCR amplification confirmed T cell clonality.The lymphocytic variant of the hypereosinophilic syndrome is a primitive lymphocytic disorder characterized by a non-malignant T cell population expansion producing eosinophilopoietic cytokines, with an indolent clinical course but that can transform into a peripheral T lymphoma. We report the first case of such a variant published in our country and review the characteristics of this variety.