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Capnocytophaga canimorsus is a Gram-negative bacillus of the commensal flora of dogs and cats that can cause infections in humans through bites, scratches or contact with oral secretions. It can be difficult to identify in clinical microbiology laboratories because of the need for specific culture media. We present the case of a patient with no relevant medical history who was admitted with septic shock, where blood smear examination was crucial for the etiologic diagnosis of Capnocytophaga canimorsus infection. The patient was also diagnosed Pelger-Huët anomaly, a condition causing a defect in neutrophil chemotaxis, which may have contributed to the severity of the infection., (© 2022. Japanese Society of Hematology.)

Diethylammonium nitrate, [N 0 0 2 2 ][NO 3 ], and its perdeuterated analogue, [N D D  2 2 ] [NO 3 ], were structurally characterized and studied by infrared, Raman, and inelastic neutron scattering (INS) spectroscopy. Using these experimental data along with state-of-the-art computational materials modeling, we report unambiguous spectroscopic signatures of hydrogen-bonding interactions between the two counterions. An exhaustive assignment of the spectral features observed with each technique has been provided, and a number of distinct modes related to NH···O dynamics have been identified. We put a particular emphasis on a detailed interpretation of the high-resolution, broadband INS experiments. In particular, the INS data highlight the importance of conformational degrees of freedom within the alkyl chains, a ubiquitous feature of ionic liquid (IL) systems. These findings also enable an in-depth physicochemical understanding of protonic IL systems, a first and necessary step to the tailoring of hydrogen-bonding networks in this important class of materials., Competing Interests: The authors declare no competing financial interest., (© 2021 The Authors. Published by American Chemical Society.)

The Spanish Acquired Hemophilia A (AHA) Registry is intended to update the status of AHA in Spain. One hundred and fifty-four patients were included and retrospectively followed for a median of 12 months. Patients were predominantly male (56.3%), with median age at diagnosis of 74 years. AHA was more frequently idiopathic (44.1%) and autoimmune disorder-associated (31.7%). Thirty-four percent of patients were on antithrombotic therapy at diagnosis. Hemostatic treatment was used in 70% of patients. Recombinant activated factor VII was more frequently infused (60.3% vs 20.6% activated prothrombin complex concentrate). Only 1 patient did not achieve control of hemorrhage. Complete remission (CR) was achieved by 84.2% of cases after immunosuppressive therapy. Steroids alone were less efficient than the other strategies (68.2% vs 87.2%, P = .049), whereas no differences existed among these (steroids/cyclophosphamide, 88.5%, vs steroids/calcineurin inhibitors, 81.2%, vs rituximab-based regimens, 87.5%). Female sex and high inhibitor levels influenced CR negatively. Thirty-six deaths (23.8%) were reported. Main causes of death were infection (15 patients, 9.9%) and hemorrhage (5 patients, 3.3%). All hemorrhage-related and half the infection-related deaths occurred within 2 months of diagnosis. Prior antithrombotic therapy was inversely associated with survival, irrespective of age. Median age of nonsurvivors was significantly higher (79 vs 73 years in survivors). Patients dying of infection were older than the other nonsurvivors (85 vs 78 years). In summary, fatal infection in the first months is common in our series. Antithrombotic therapy is associated with mortality. Particular care should be taken to avoid misdiagnosis., (© 2021 by The American Society of Hematology.)

Alternatives to lead- and tin-based perovskites for photovoltaics and optoelectronics are sought that do not suffer from the disadvantages of toxicity and low device efficiency of present-day materials. Here we report a study of the double perovskite Cs 2 TeI 6 , which we have synthesized in the thin film form for the first time. Exhaustive trials concluded that spin coating CsI and TeI 4 using an antisolvent method produced uniform films, confirmed as Cs 2 TeI 6 by XRD with Rietveld analysis. They were stable up to 250 °C and had an optical band gap of ∼1.5 eV, absorption coefficients of ∼6 × 10 4 cm -1 , carrier lifetimes of ∼2.6 ns (unpassivated 200 nm film), a work function of 4.95 eV, and a p-type surface conductivity. Vibrational modes probed by Raman and FTIR spectroscopy showed resonances qualitatively consistent with DFT Phonopy -calculated spectra, offering another route for phase confirmation. It was concluded that the material is a candidate for further study as a potential optoelectronic or photovoltaic material., Competing Interests: The authors declare no competing financial interest., (Copyright © 2020 American Chemical Society.)

This study is centered on the thermophysical characterization of different families of alkylammonium nitrate ionic liquids and their binary mixtures, namely the determination at atmospheric pressure of densities, electric conductivities and viscosities in the 288.15 < T/K < 353.15 range. First, measurements focusing on ethylammonium, propylammonium and butylammonium nitrate systems, and their binary mixtures, were determined. These were followed by studies involving binary mixtures composed of ethylammonium nitrate (with three hydrogen bond donor groups) and different homologous ionic liquids with differing numbers of hydrogen bond donor groups: diethylammonium nitrate (two hydrogen bond donors), triethylammonium nitrate (one hydrogen bond donor) and tetraethylammonium nitrate (no hydrogen bond donors). Finally, the behavior of mixtures with different numbers of equivalent carbon atoms in the alkylammonium cations was analyzed. The results show a quasi-ideal behavior for all monoalkylammonium nitrate mixtures. In contrast, the other mixtures show deviations from ideality, namely when the difference in the number of carbon atoms present in the cations increases or the number of hydrogen bond donors present in the cation decreases. Overall, the results clearly show that, besides the length and distribution of alkyl chains present in a cation such as alkylammonium, there are other structural and interaction parameters that influence the thermophysical properties of both pure compounds and their mixtures.