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22 results on '"Vázquez-Rivera, Francisca"'

1. Dynamic nature of BRAF or KRAS p.G12C mutations in second-line therapy for advanced colorectal cancer patients: do early and late effects exist?

Author

Contreras-Toledo, Débora, Jiménez-Fonseca, Paula, López, Carlos López, Montes, Ana Fernández, López Muñoz, Ana María, Vázquez Rivera, Francisca, Alonso, Vicente, Alcaide, Julia, Salvà, Francesc, Covela Rúa, Marta, Guillot, Mónica, Martín Carnicero, Alfonso, Jimeno Mate, Raquel, Cameselle García, Soledad, Asensio Martínez, Elena, González Astorga, Beatriz, Fernandez-Diaz, Amaya B., González Villaroel, Paula, Virgili Manrique, Anna C., Melián Sosa, Marcos, Alonso, Beatriz, Cousillas Castiñeiras, Antia, Castañón López, Carmen, Aparicio, Jorge, and Carmona-Bayonas, Alberto

Published
2024
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3. Clinical significance of baseline Pan-Immune-Inflammation Value and its dynamics in metastatic colorectal cancer patients under first-line chemotherapy

Author

Pérez-Martelo, Martín, González-García, Alejandro, Vidal-Ínsua, Yolanda, Blanco-Freire, Cristina, Brozos-Vázquez, Elena María, Abdulkader-Nallib, Ihab, Álvarez-Fernández, Javier, Lázare-Iglesias, Héctor, García-Martínez, Carolina, Betancor, Yoel Z., Sánchez-Ares, María, Tubío, Jose M. C., Vázquez-Rivera, Francisca, Candamio-Folgar, Sonia, López-López, Rafael, and Ruiz-Bañobre, Juan

Published
2022
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4. Molecularly targeted therapy in metastatic CRC

Author

Ruiz-Bañobre, Juan, primary, Brozos-Vázquez, Elena, additional, Vázquez-Rivera, Francisca, additional, Vidal-Ínsua, Yolanda, additional, López-López, Rafael, additional, and Candamio-Folgar, Sonia, additional

Published
2022
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5. Contributors

Author

Aguilar, José Francisco Noguera, primary, Alhayek-Aí, Mohammed, additional, Alonso Aguirre, Pedro A., additional, Álvarez-Chaver, Paula, additional, Alvarez-Gonzalez, Sara, additional, Álvarez-Santullano, Lucía, additional, Alvariño, Javier Castro, additional, Amigo, Jorge, additional, Antón Aparicio, Luis M., additional, Aptsiauri, Natalia, additional, Ares, María Sánchez, additional, Balea, Begoña Campos, additional, Balo, Paula Vieiro, additional, Barcia, Lucía, additional, Bou, Germán, additional, Barreiro, Vanesa Balboa, additional, Bendayán, Isaac Martínez, additional, Bernal, Mónica, additional, Briones, Pedro Carpintero, additional, Brozos-Vázquez, Elena, additional, Bueno, Begoña Bravo, additional, Burundarena, Alba, additional, Caamaño, Antonio Gómez, additional, Calviño, José Manuel Mera, additional, Calvo, Marcos, additional, Candamio-Folgar, Sonia, additional, Cardelle-Cobas, Alejandra, additional, Carracedo, Ángel, additional, Carrasco, Ainhoa, additional, Castro, Álvaro Gómez, additional, Castro, Ana María Carballo, additional, Cepeda, Alberto, additional, Cepeda-Emiliani, Alfonso, additional, Concha, Ángel, additional, Conde, Benito González, additional, Cordero, Oscar J., additional, Cortés, Alberto Centeno, additional, Cotoré, Jesús Paredes, additional, Crespo, Patricia Calvo, additional, de Castro, Alain García, additional, De Chiara, Loretta, additional, de la Ballina González, Enrique González, additional, de Llano, Sofía Rodríguez Martínez, additional, Deben, Manuel Núñez, additional, del Carmen Corujeira Rivera, M., additional, Díaz, Cristina Méndez, additional, Díaz, Sonia Pértega, additional, Diéguez, Leticia García, additional, D'Jesús, Antonio Rodríguez, additional, Dourado, Ramón Vázquez, additional, Dovigo, Alba Gómez, additional, Fajardo, Paloma Sosa, additional, Fernández, Nereida Fernández, additional, Fernández, Rafaela Soler, additional, Fernández, Rosalía, additional, Fernández, Sergio Manuel Estévez, additional, Fernandez-Lozano, Carlos, additional, Fernández-Rozadilla, Ceres, additional, Ferreiro, Raquel Sardina, additional, Ferreiro, Silvia Varela, additional, Figueiras, Roberto García, additional, Figueroa, Angélica, additional, Fontoira, Lydia Fraga, additional, Franco, Carlos M.N, additional, Gallardo-Gómez, María, additional, García, Concepción Crespo, additional, García, Esther Rodríguez, additional, García-López, Alba, additional, Garrido, Federico, additional, González, Javier Aguirrezabalaga, additional, González-Carreró, Joaquín, additional, Gonzalez-Rivas, Diego, additional, Graña-Suárez, Begoña, additional, Hernández, Vicent, additional, Higuero, Paula Peleteiro, additional, Iglesias, Héctor Lázare, additional, Lago, Orlando Fernández, additional, Lamas, Alexandre, additional, Liñares-Blanco, Jose, additional, Llanas, María Jose Martinez-Sapiña, additional, López, Fernando Fernández, additional, López, José Ramón Antúnez, additional, López-López, Rafael, additional, López-Novo, Anael, additional, Lorenzo, Carmen Álvarez, additional, Loureiro, Miguel Pereira, additional, Macenlle García, Ramiro Manuel, additional, Maldonado, Shirly Margarita Nieves, additional, Marcos, Sara Seijas, additional, Marqués, Eva Martí, additional, Martín, Cristina González, additional, Martínez, Arantza Germade, additional, Martínez Lago, Nieves, additional, Martínez-Bernal, Gala, additional, Martínez-Pérez, Julia, additional, Mato-Abad, Virginia, additional, Méndez, Silvia Louzao, additional, Montalvo, Manuel Bustamante, additional, Mosquera, Beatriz Romero, additional, Muñoz, Catuxa Celeiro, additional, Munteanu, Cristian R., additional, Nine, Ángel Concheiro, additional, Novoa, Alejandra García, additional, Oreiro, Martina Lema, additional, Osuna, Francisco Ruíz-Cabello, additional, Otero, María, additional, Otero Muinelo, Susana A., additional, Parada, Pilar Díaz, additional, Paredes Cotoré, Jesús P., additional, Pazos, Alejandro, additional, Pazos García, Alejandro, additional, Pazos García, Carla, additional, Pedreira, Nieves, additional, Pillado, María Teresa Seoane, additional, Piñeiro, Susana López, additional, Poza, Margarita, additional, Purriños, Natalia Cal, additional, Queipo, Francisco, additional, Regal, Patricia, additional, Reinquet, Fernando Zelaya, additional, Rey, María Teresa Vázquez, additional, Rivas, Andrés Dacal, additional, Rocha, José Luis Ulla, additional, Rodríguez, Alejandro Ledo, additional, Rodríguez, Francisco Javier González, additional, Rodríguez, Gerardo Baños, additional, Rodríguez, María Teresa García, additional, Rodríguez, Máximo Fraga, additional, Rojas, Miriam, additional, Rosés, Leopoldo López, additional, Rúa, Marta Covela, additional, Ruiz-Bañobre, Juan, additional, Ruiz-Ponte, Clara, additional, Saavedra, Francisco Javier Maestro, additional, Sacristán Santos, Víctor, additional, Said-Criado, Ismael, additional, Sánchez, Aliuska Duardo, additional, Santamaría, Paloma González, additional, Sardenberg, Rodrigo A.S., additional, Sieira, Antonio Jurjo, additional, Silva, Paulino Pais, additional, Suarez, Rosa Fungueiriño, additional, Taboada, Tatiana María Civeira, additional, Trillo, Adriana Barreiro, additional, Trillo, Rosa, additional, Vázquez-Tunas, M. Lidia, additional, Turnes, Alfonso Martínez, additional, Valladares, Begoña Taboada, additional, Valladares-Ayerbes, Manuel, additional, Varela, Vanesa Val, additional, Varela-Calviño, Rubén, additional, Vázquez, Beatriz I., additional, Vázquez, Carla Blanco, additional, Vázquez, Juan Turnes, additional, Vázquez, Pablo Parada, additional, Vázquez, Vanesa Vilanova, additional, Vázquez-Naya, José M., additional, Vázquez-Rivera, Francisca, additional, Veiga, Alberto, additional, Vidal-Ínsua, Yolanda, additional, Vilas, Alba María Arceo, additional, and Worner, Ignacio Couto, additional

Published
2022
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7. Prediction of survival in patients with advanced, refractory colorectal cancer in treatment with trifluridine/tipiracil: real-world vs clinical trial data

Author

Fernández Montes, Ana, Carmona-Bayonas, Alberto, Jimenez-Fonseca, Paula, Vázquez Rivera, Francisca, Martinez Lago, Nieves, Covela Rúa, Marta, Cousillas Castiñeiras, Antía, Gonzalez Villarroel, Paula, De la Cámara Gómez, Juan, Méndez, José Carlos Méndez, Carriles Fernández, Carmen, Sanchez Cánovas, Manuel, and Garcia García, Teresa

Published
2021
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8. Human-in-the-Loop Machine Learning for the Treatment of Pancreatic Cancer

Author

Mosqueira-Rey, Eduardo, primary, Pérez-Sánchez, Alberto, additional, Hernández-Pereira, Elena, additional, Alonso-Ríos, David, additional, Bobes-Bascarán, José, additional, Fernández-Leal, Ángel, additional, Moret-Bonillo, Vicente, additional, Vidal-Ínsua, Yolanda, additional, and Vázquez-Rivera, Francisca, additional

Published
2023
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9. Addressing the data bottleneck in medical deep learning models using a human-in-the-loop machine learning approach

Author

Mosqueira-Rey, E., Hernández-Pereira, Elena, Bobes-Bascarán, José, Alonso Ríos, David, Pérez-Sánchez, Alberto, Fernández-Leal, Ángel, Moret-Bonillo, Vicente, Vidal-Ínsua, Yolanda, Vázquez-Rivera, Francisca, Mosqueira-Rey, E., Hernández-Pereira, Elena, Bobes-Bascarán, José, Alonso Ríos, David, Pérez-Sánchez, Alberto, Fernández-Leal, Ángel, Moret-Bonillo, Vicente, Vidal-Ínsua, Yolanda, and Vázquez-Rivera, Francisca

Abstract

[Abstract]: Any machine learning (ML) model is highly dependent on the data it uses for learning, and this is even more important in the case of deep learning models. The problem is a data bottleneck, i.e. the difficulty in obtaining an adequate number of cases and quality data. Another issue is improving the learning process, which can be done by actively introducing experts into the learning loop, in what is known as human-in-the-loop (HITL) ML. We describe an ML model based on a neural network in which HITL techniques were used to resolve the data bottleneck problem for the treatment of pancreatic cancer. We first augmented the dataset using synthetic cases created by a generative adversarial network. We then launched an active learning (AL) process involving human experts as oracles to label both new cases and cases by the network found to be suspect. This AL process was carried out simultaneously with an interactive ML process in which feedback was obtained from humans in order to develop better synthetic cases for each iteration of training. We discuss the challenges involved in including humans in the learning process, especially in relation to human–computer interaction, which is acquiring great importance in building ML models and can condition the success of a HITL approach. This paper also discusses the methodological approach adopted to address these challenges.

Published
2023

11. Effect of antiangiogenic-based treatment and systemic inflammatory factors on outcomes in patients with BRAF v600-mutated metastatic colorectal cancer: a real-world study in Spain.

Author

Martínez-Lago, Nieves, Fernández-Montes, Ana, Covela, Marta, Brozos, Elena M., De la Cámara, Juan, Méndez Méndez, José C., Jorge-Fernández, Mónica, Cousillas Castiñeiras, Antía, Reboredo, Cristina, Arias Ron, David, Pellón Augusto, María L., González Villarroel, Paula, Graña, Begoña, Salgado Fernández, Mercedes, Carral Maseda, Alberto, Vázquez Rivera, Francisca, Candamio Folgar, Sonia, Reboredo López, Margarita, and Galician Research Group on Digestive Tumors (GITuD)

Subjects
COLORECTAL cancer, METASTASIS, TREATMENT effectiveness, LYMPHOCYTES, SERUM albumin, SURVIVAL, RESEARCH, NEOVASCULARIZATION inhibitors, GENETIC mutation, INFLAMMATION, BLOOD platelets, RESEARCH methodology, RETROSPECTIVE studies, PROGNOSIS, EVALUATION research, NEUTROPHILS, COMPARATIVE studies, TRANSFERASES, RESEARCH funding, LONGITUDINAL method
Abstract

Background: Outcomes are poorer in metastatic colorectal cancer (mCRC) patients with BRAF V600E mutations than those without it, but the effect of these mutations on treatment response is unclear. This real-world study assessed the effects of antiangiogenic-based treatment and systemic inflammatory factors on outcomes in patients with BRAF V600-mutated mCRC.Methods: This real-world, multicenter, retrospective, observational study included patients with BRAF V600-mutated mCRC treated in eight hospitals in Spain. The primary endpoints were overall survival (OS) and progression-free survival (PFS); overall response rate (ORR) and disease control rate (DCR) were also assessed. The effect of first- and second-line treatment type on OS, PFS, ORR, and DCR were evaluated, plus the impact of systemic inflammatory markers on these outcomes. A systemic inflammation score (SIS) of 1-3 was assigned based on one point each for platelet-lymphocyte ratio (PLR) ≥200, neutrophil-lymphocyte ratio (NLR) ≥3, and serum albumin < 3.6 g/dL.Results: Of 72 patients, data from 64 were analyzed. After a median of 69.1 months, median OS was 11.9 months and median first-line PFS was 4.4 months. First-line treatment was triplet chemotherapy-antiangiogenic (12.5%), doublet chemotherapy-antiangiogenic (47.2%), doublet chemotherapy-anti-EGFR (11.1%), or doublet chemotherapy (18.1%). Although first-line treatment showed no significant effect on OS, antiangiogenic-based regimens were associated with prolonged median PFS versus non-antiangiogenic regimens. Negative predictors of survival with antiangiogenic-based treatment were NLR, serum albumin, and SIS 1-3, but not PLR. Patients with SIS 1-3 showed significantly prolonged PFS with antiangiogenic-based treatment versus non-antiangiogenic-based treatment, while those with SIS=0 showed no PFS benefit.Conclusions: Antiangiogenic-based regimens, SIS, NLR, and albumin were predictors of survival in patients with mCRC, while SIS, NLR and serum albumin may predict response to antiangiogenic-based chemotherapy.Trial Registration: GIT-BRAF-2017-01. [ABSTRACT FROM AUTHOR]

Published
2021
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12. Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study

Author

Vidal Insua, Yolanda, De La Cámara Gómez, Juan Cruz, Brozos Vázquez, Elena María, Fernández Montes, Ana, Vázquez Rivera, Francisca, Villanueva Silva, María José, Barbazán García, Jorge, Muinelo Romay , Laura, Candamio Folgar, Sonia, Abalo Piñeiro, Alicia, López López, Rafael, Abal Posada, Miguel, and Alonso Alconada, Lorena

Subjects
Células tumorales circulantes, neoplasias colorrectales, células neoplásicas circulantes, Cáncer colorrectal metastásico, Tumor maligno del colon, parte no especificada, Neoplastic Cells, Circulating, Disease-Free Survival, Detección temprana del cáncer, Survival Rate, detección precoz del cáncer, Biomarcadores, supervivencia sin enfermedad, tasa de supervivencia, Neoplasm Metastasis, Colorectal Neoplasms, Early Detection of Cancer, metástasis neoplásica, Biomarkers, Respuesta al tratamiento
Abstract

Colorectal cancer (CRC) is one of the major causes of cancer-related deaths. Early detection of tumor relapse is crucial for determining the most appropriate therapeutic management. In clinical practice, computed tomography (CT) is routinely used, but small tumor changes are difficult to visualize, and reliable blood-based prognostic and monitoring biomarkers are urgently needed. The aim of this study was to prospectively validate a gene expression panel (composed of GAPDH, VIL1, CLU, TIMP1, TLN1, LOXL3 and ZEB2) for detecting circulating tumor cells (CTCs) as prognostic and predictive tool in blood samples from 94 metastatic CRC (mCRC) patients. Patients with higher gene panel expression before treatment had a reduced progression-free survival (PFS) and overall-survival (OS) rates compared with patients with low expression (p = 0.003 and p ≤ 0.001, respectively). Patients with increased expression of CTCs markers during treatment presented PFS and OS times of 8.95 and 11.74 months, respectively, compared with 14.41 and 24.7 for patients presenting decreased expression (PFS; p = 0.020; OS; p ≤ 0.001). Patients classified as non-responders by CTCs with treatment, but classified as responders by CT scan, showed significantly shorter survival times (PFS: 8.53 vs. 11.70; OS: 10.37 vs. 24.13; months). In conclusion, our CTCs detection panel demonstrated efficacy for early treatment response assessment in mCRC patients, and with increased reliability compared to CT scan. ACIS (Axencia de Coñecemento en Saude); SERGAS. Cofinanced ERDF Funds 2007–2013

Published
2017

13. Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study

Author

Vidal Insua, Yolanda, primary, de la Cámara, Juan, additional, Brozos Vázquez, Elena, additional, Fernández, Ana, additional, Vázquez Rivera, Francisca, additional, Villanueva Silva, Mª José, additional, Barbazán, Jorge, additional, Muinelo-Romay, Laura, additional, Candamio Folgar, Sonia, additional, Abalo, Alicia, additional, López-López, Rafael, additional, Abal, Miguel, additional, and Alonso-Alconada, Lorena, additional

Published
2017
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20. Methylphenidate in the management of asthenia in breast cancer patients treated with docetaxel: Results of a pilot study

Author

Anido Herranz, Urbano, León Mateos, Luis Ángel, Candamio Folgar, Sonia, Gallardo Martín , Maria Elena, López López, Rafael, Areses Manrique, María Carmen, Cueva Bañuelos, Juan Fernando, Curiel Garcïa, Teresa, Bernárdez Ferrán, Beatriz, Lamas Díaz, María Jesús, Vidal Insua, Yolanda, Vázquez Rivera, Francisca, Barón Duarte, Francisco Javier, Gayoso Couce, Lucía, and García González, Jorge José

Published
2012

21. Metastatic and unresectable biliary tract tumors: A single-center retrospective review

Author

Anido Herranz, Urbano, Vieito Villar, María, Candamio Folgar, Sonia, Gallardo Martín , Maria Elena, López López, Rafael, Cueva Bañuelos, Juan Fernando, Vidal Insua, Yolanda, Vázquez Rivera, Francisca, Brozos Vázquez, Elena María, Martinez Lago, Nieves Purificacion, Aguin Losada, Santiago, Carmona Campos, Marta, Rodríguez López, Carmela, and Varela Ponte, Rafael

Published
2012

22. Do Clinical Trials Meet Current Care Needs? Views of Digestive Oncology Specialists in Galicia (Spain) Using the Delphi Method.

Author

Fernández Montes, Ana, Martinez-Lago, Nieves, de la Cámara Gomez, Juan, Brozos Vázquez, Elena María, Candamio Folgar, Sonia, Carmona Campos, Marta, Cousillas Castiñeiras, Antía, Covela Rúa, Marta, Gallardo Martín, Elena, González Villarroel, Paula, Graña Suarez, Begoña, Jorge Fernández, Mónica, Pellón Augusto, María Luz, Quintero Aldana, Guillermo, Romero Reinoso, Carlos, Salgado Fernández, Mercedes, Vázquez Rivera, Francisca, Ayuso Álvarez, Ana, Culqui, Dante R., and Méndez Méndez, José Carlos

Subjects
DELPHI method, CLINICAL trials, COMPUTED tomography, MEDICAL personnel, DECISION making, ONCOLOGY
Abstract

Background: In recent years, abundant scientific evidence has been generated based on clinical trials (CT) in the field of oncology. The general objective of this paper is to find out the extent to which decision making is based on knowledge of the most recent CT. Its specific objectives are to pinpoint difficulties with decision making based on the CT performed and find out the motivations patients and clinicians have when taking part in a CT. Methodology: Combined, prospective study, based on the Delphi method. A lack of correspondence between the people who take part in CT and patients who come for consultation has been identified. A need for training in analysing and interpreting CT has also been identified and a lack of trust in the results of CT financed by the pharmaceutical industry itself has been perceived. Conclusions: There is a difficulty in selecting oncological treatment due to the lack of correspondence between the patients included in the CT and patients seen in consultation. In this process, real world data studies may be highly useful, as they may provide this group with greater training in interpreting CT and their results. [ABSTRACT FROM AUTHOR]

Published
2021
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