Author: "V (Di, Carlo" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"V (Di, Carlo"' showing total 694 results

Start Over Author "V (Di, Carlo"

694 results on '"V (Di, Carlo"'

1. Longitudinal ultrasound evaluation of clear-cell ovarian carcinoma

Author: Giovanni Scambia, V. Di Carlo, Caterina Exacoustos, Francesca Moro, I. De Blasis, and A. C. Testa
Subjects: Adult, Pathology, medicine.medical_specialty, Ovary, Pregnant, ovarian cancer, ovary, ultrasonography, Ultrasound, Medical Illustration, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Longitudinal Studies, Clear-cell ovarian carcinoma, myomectomy, Ultrasonography, Ovarian Neoplasms, Radiological and Ultrasound Technology, business.industry, Obstetrics and Gynecology, General Medicine, medicine.disease, medicine.anatomical_structure, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Reproductive Medicine, Settore MED/40, Female, business, Ovarian cancer, Adenocarcinoma, Clear Cell
Published: 2020

2. Lessons from in Vitro Perifusion of Pancreatic Islets Isolated from 80 Human Pancreases

Author: F. Bertuzzi M.D., P. Garancini, C. Socci, R. Nano, M. V. Taglietti, M. Santopinto, V. Di Carlo, and A. M. Davalli
Subjects: Medicine
Abstract: We report the average insulin response to acute glucose measured by in vitro perifusion of pancreatic islets isolated from 80 consecutive human organs. Different perifusion parameters were considered [basal release, stimulation index (SI), time to peak, incremental area under the curve Δ-AUCa)], and the correlation among them was determined. SI positively correlated with Δ-AUCa (p < 0.001, r = 0.80) while negatively with time to peak (p < 0.05, r = −0.23). We also evaluated several variables of the isolation procedure that might affect responsiveness to glucose by human islets. Sex and age of pancreas donors, cold ischemia time, duration of the digestion, collagenase concentration, and lot characteristics (collagenase, trypsin, clostripain, and proteases activity), and final islet yield were considered. Multivariate regression analysis showed only an independent association between SI and the concentration of collagenase (p = 0.01).
Published: 1999
Full Text: View/download PDF

3. Global surveillance of trends in cancer survival 2000-14 (concord-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Author: Claudia Allemani, Tomohiro Matsuda, Veronica Di Carlo, Rhea Harewood, Melissa Matz, Maja Nikšić, Audrey Bonaventure, Mikhail Valkov, Christopher J Johnson, Jacques Estève, Olufemi J Ogunbiyi, Gulnar Azevedo e Silva, Wan-Qing Chen, Sultan Eser, Gerda Engholm, Charles A Stiller, Alain Monnereau, Ryan R Woods, Otto Visser, Gek Hsiang Lim, Joanne Aitken, Hannah K Weir, Michel P Coleman, S Bouzbid, M Hamdi-Chérif, Z Zaidi, K Meguenni, D Regagba, S Bayo, T Cheick Bougadari, S S Manraj, A Fabowale, O J Ogunbiyi, D Bradshaw, N I M Somdyala, I Kumcher, F Moreno, G H Calabrano, S B Espinola, B Carballo Quintero, R Fita, M C Diumenjo, W D Laspada, S G Ibañez, C A Lima, P C F De Souza, K Del Pino, C Laporte, M P Curado, J C de Oliveira, C L A Veneziano, D B Veneziano, M R D O Latorre, L F Tanaka, M S Rebelo, M O Santos, G Azevedo e Silva, J C Galaz, M Aparicio Aravena, J Sanhueza Monsalve, D A Herrmann, S Vargas, V M Herrera, C J Uribe, L E Bravo, L S Garcia, N E Arias-Ortiz, D Morantes, D M Jurado, M C Yépez Chamorro, S Delgado, M Ramirez, Y H Galán Alvarez, P Torres, F Martínez-Reyes, L Jaramillo, R Quinto, J, M Mendoza, P Cueva, J G Yépez, B Bhakkan, J Deloumeaux, C Joachim, J Macni, R Carrillo, J Shalkow Klincovstein, R Rivera Gomez, E Poquioma, G Tortolero-Luna, D Zavala, R Alonso, E Barrios, A Eckstrand, C Nikiforuk, R R Woods, G Noonan, D Turner, E Kumar, B Zhang, F R McCrate, S Ryan, M MacIntyre, N Saint-Jacques, D E Nishri, C A McClure, K A Vriends, S Kozie, H Stuart-Panko, T Freeman, J T George, J T Brockhouse, D K O'Brien, A Holt, L Almon, S Kwong, C Morris, R Rycroft, L Mueller, C E Phillips, H Brown, B Cromartie, A G Schwartz, F Vigneau, G M Levin, B Wohler, R Bayakly, K C Ward, S L Gomez, M McKinley, R Cress, M D Green, K Miyagi, C J Johnson, L P Ruppert, C F Lynch, B Huang, T C Tucker, D Deapen, L Liu, M C Hsieh, X C Wu, M Schwenn, S T Gershman, R C Knowlton, G Alverson, G E Copeland, S Bushhouse, D B Rogers, J Jackson-Thompson, D Lemons, H J Zimmerman, M Hood, J Roberts-Johnson, J R Rees, B Riddle, K S Pawlish, A Stroup, C Key, C Wiggins, A R Kahn, M J Schymura, S Radhakrishnan, C Rao, L K Giljahn, R M Slocumb, R E Espinoza, F Khan, K G Aird, T Beran, J J Rubertone, S J Slack, L Garcia, D L Rousseau, T A Janes, S M Schwartz, S W Bolick, D M Hurley, M A Whiteside, P Miller-Gianturco, M A Williams, K Herget, C Sweeney, A T Johnson, M B Keitheri Cheteri, P Migliore Santiago, S E Blankenship, S Farley, R Borchers, R Malicki, J R Espinoza, J Grandpre, H K Weir, R Wilson, B K Edwards, A Mariotto. Y Lei, N Wang, J S Chen, Y Zhou, Y T He, G H Song, X P Gu, D Mei, H J Mu, H M Ge, T H Wu, Y Y Li, D L Zhao, F Jin, J H Zhang, F D Zhu, Q Junhua, Y L Yang, C X Jiang, W Biao, J Wang, Q L Li, H Yi, X Zhou, J Dong, W Li, F X Fu, S Z Liu, J G Chen, J Zhu, Y H Li, Y Q Lu, M Fan, S Q Huang, G P Guo, H Zhaolai, K Wei, W Q Chen, H Zeng, A V Demetriou, W K Mang, K C Ngan, A C Kataki, M Krishnatreya, P A Jayalekshmi, P Sebastian, A Nandakumar, R Malekzadeh, G Roshandel, L Keinan-Boker, B G Silverman, H Ito, H Nakagawa, M Sato, F Tobori, I Nakata, N Teramoto, M Hattori, Y Kaizaki, F Moki, H Sugiyama, M Utada, M Nishimura, K Yoshida, K Kurosawa, Y Nemoto, H Narimatsu, M Sakaguchi, S Kanemura, M Naito, R Narisawa, I Miyashiro, K Nakata, S Sato, M Yoshii, I Oki, N Fukushima, A Shibata, K Iwasa, C Ono, T Matsuda, O Nimri, K W Jung, Y J Won, E Alawadhi, A Elbasmi, A Ab Manan, F Adam, E Sanjaajmats, U Tudev, C Ochir, A M Al Khater, M M El Mistiri, G H Lim, Y Y Teo, C J Chiang, W C Lee, R Buasom, S Sangrajrang, S Kamsaard, S Wiangnon, K Daoprasert, D Pongnikorn, A Leklob, S Sangkitipaiboon, S L Geater, H Sriplung, O Ceylan, I Kög, O Dirican, T Köse, T Gurbuz, F E Karaşahin, D Turhan, U Aktaş, Y Halat, S Eser, C I Yakut, M Altinisik, Y Cavusoglu, A Türkköylü, N Üçüncü, M Hackl, A A Zborovskaya, O V Aleinikova, K Henau, L Van Eycken, Z Valerianova, M R Yordanova, M Šekerija, L Dušek, M Zvolský, G Engholm, H Storm, K Innos, M Mägi, N Malila, K Seppä, J Jégu, M Velten, E Cornet, X Troussard, A M Bouvier, A V Guizard, V Bouvier, G Launoy, P Arveux, M Maynadié, M Mounier, A S Worono, M Daoulas, M Robaszkiewicz, J Clavel, S Goujon, B Lacour, I Baldi, C Pouchieu, B Amadeo, G Coureau, A Monnereau, S Orazio, P M Preux, F Rharbaoui, E Marrer, B Trétarre, M Colonna, P Delafosse, K Ligier, S Plouvier, A Cowppli-Bony, F Molinié, S Bara, O Ganry, B Lapôtre- Ledoux, P Grosclaude, N Bossard, Z Uhry, F Bray, M Piñeros, J Estève, R Stabenow, H Wilsdorf-Köhler, A Eberle, S Luttmann, I Löhden, A L Nennecke, J Kieschke, E Sirri, K Emrich, S R Zeissig, B Holleczek, N Eisemann, A Katalinic, R A Asquez, V Kumar, E Petridou, E J Ólafsdóttir, L Tryggvadóttir, K Clough-Gorr, P M Walsh, H Sundseth, G Mazzoleni, F Vittadello, E Coviello, F Cuccaro, R Galasso, G Sampietro, A Giacomin, M Magoni, A Ardizzone, A D'Argenzio, M Castaing, G Grosso, A M Lavecchia, A Sutera Sardo, G Gola, L Gatti, P Ricci, S Ferretti, D Serraino, A Zucchetto, M V Celesia, R A Filiberti, F Pannozzo, A Melcarne, F Quarta, A G Russo, G Carrozzi, C Cirilli, L Cavalieri d'Oro, M Rognoni, M Fusco, M F Vitale, M Usala, R Cusimano, W Mazzucco, M Michiara, P Sgargi, L Boschetti, E Borciani, P Seghini, M M Maule, F Merletti, R Tumino, P Mancuso, M Vicentini, T Cassetti, R Sassatelli, F Falcini, S Giorgetti, A L Caiazzo, R Cavallo, R Cesaraccio, D R Pirino, M L Contrino, F Tisano, A C Fanetti, S Maspero, S Carone, A Mincuzzi, G Candela, T Scuderi, M A Gentilini, S Pier, S Rosso, A Barchielli, A Caldarella, F Bianconi, F Stracci, P Contiero, G Tagliabue, M Rugge, M Zorzi, S Beggiato, A Brustolin, F Berrino, G Gatta, M Sant, C Buzzoni, L Mangone, R Capocaccia, R De Angelis, R Zanetti, A Maurina, S Pildava, N Lipunova, I Vincerževskienė, D Agius, N Calleja, S Siesling, O Visser, Larønningen, B Møller, A Dyzmann-Sroka, M Trojanowski, S Góźdź, R Mężyk, T Mierzwa, L Molong, J Rachtan, S Szewczyk, J Błaszczyk, K Kępska, B Kościańska, K Tarocińska, M Zwierko, K Drosik, K M Maksimowicz, E Purwin-Porowska, E Reca, J Wójcik-Tomaszewska, A Tukiendorf, M Grądalska-Lampart, A U Radziszewska, A Gos, M Talerczyk, M Wyborska, J A Didkowska, U Wojciechowska, M Bielska-Lasota, G Forjaz de Lacerda, R A Rego, J Bastos, M A Silva, L Antunes, J Laranja Pontes, A Mayer-da-Silva, A Miranda, L M Blaga, D Coza, Russia: M Y Valkov, L Gusenkova, O Lazarevich, O Prudnikova, D M Vjushkov, A G Egorova, A E Orlov, L A Kudyakov, L V Pikalova, J Adamcik, C Safaei Diba, M Primic-Žakelj, V Zadnik, N Larrañaga, A Lopez de Munain, A A Herrera, R Redondas, R Marcos-Gragera, M L Vilardell Gil, E Molina, M J Sánchez Perez, P Franch Sureda, M Ramos Montserrat, M D Chirlaque, C Navarro, E E Ardanaz, M M Guevara, R Fernández-Delgado, R Peris-Bonet, M Carulla, J Galceran, C Alberich, M Vicente-Raneda, S Khan, D Pettersson, P Dickman, I Avelina, K Staehelin, B Camey, C Bouchardy, R Schaar, H Frick, C Herrmann, J L Bulliard, M Maspoli-Conconi, C E Kuehni, S M Redmond, A Bordoni, L Ortelli, A Chiolero, I Konzelmann, K L Matthes, S Rohrmann, Broggio, J Rashbass, D Fitzpatrick, A Gavin, D I Clark, A J Deas, D W Huws, C White, C Allemani, A Bonaventure, M P Coleman, V Di Carlo, R Harewood, M Matz, L Montel, M Nikšić, B Rachet, A D Turculeț, R Stephens, C A Stiller, E Chalker, H Phung, R Walton, H You, S Guthridge, F Johnson, J Aitken, P Gordon, K D'Onise, K Priest, B C Stokes, A Venn, H Farrugia, V Thurs eld, J Dowlin, D Currow, J Hendrix, C Lewis, Tıp Fakültesi, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Claudia Allemani, Tomohiro Matsuda, Veronica Di Carlo, Rhea Harewood, Melissa Matz, Maja Nikšić, Audrey Bonaventure, Mikhail Valkov, Christopher J Johnson, Jacques Estève, Olufemi J Ogunbiyi, Gulnar Azevedo e Silva, Wan-Qing Chen, Sultan Eser, Gerda Engholm, Charles A Stiller, Alain Monnereau, Ryan R Woods, Otto Visser, Gek Hsiang Lim, Joanne Aitken, Hannah K Weir, Michel P Coleman, S Bouzbid, M Hamdi-Chérif, Z Zaidi, K Meguenni, D Regagba, S Bayo, T Cheick Bougadari, S S Manraj, A Fabowale, O J Ogunbiyi, D Bradshaw, N I M Somdyala, I Kumcher, F Moreno, G H Calabrano, S B Espinola, B Carballo Quintero, R Fita, M C Diumenjo, W D Laspada, S G Ibañez, C A Lima, P C F De Souza, K Del Pino, C Laporte, M P Curado, J C de Oliveira, C L A Veneziano, D B Veneziano, M R D O Latorre, L F Tanaka, M S Rebelo, M O Santos, G Azevedo e Silva, J C Galaz, M Aparicio Aravena, J Sanhueza Monsalve, D A Herrmann, S Vargas, V M Herrera, C J Uribe, L E Bravo, L S Garcia, N E Arias-Ortiz, D Morantes, D M Jurado, M C Yépez Chamorro, S Delgado, M Ramirez, Y H Galán Alvarez, P Torres, F Martínez-Reyes, L Jaramillo, R Quinto, J, M Mendoza, P Cueva, J G Yépez, B Bhakkan, J Deloumeaux, C Joachim, J Macni, R Carrillo, J Shalkow Klincovstein, R Rivera Gomez, E Poquioma, G Tortolero-Luna, D Zavala, R Alonso, E Barrios, A Eckstrand, C Nikiforuk, R R Woods, G Noonan, D Turner, E Kumar, B Zhang, F R McCrate, S Ryan, M MacIntyre, N Saint-Jacques, D E Nishri, C A McClure, K A Vriends, S Kozie, H Stuart-Panko, T Freeman, J T George, J T Brockhouse, D K O'Brien, A Holt, L Almon, S Kwong, C Morris, R Rycroft, L Mueller, C E Phillips, H Brown, B Cromartie, A G Schwartz, F Vigneau, G M Levin, B Wohler, R Bayakly, K C Ward, S L Gomez, M McKinley, R Cress, M D Green, K Miyagi, C J Johnson, L P Ruppert, C F Lynch, B Huang, T C Tucker, D Deapen, L Liu, M C Hsieh, X C Wu, M Schwenn, S T Gershman, R C Knowlton, G Alverson, G E Copeland, S Bushhouse, D B Rogers, J Jackson-Thompson, D Lemons, H J Zimmerman, M Hood, J Roberts-Johnson, J R Rees, B Riddle, K S Pawlish, A Stroup, C Key, C Wiggins, A R Kahn, M J Schymura, S Radhakrishnan, C Rao, L K Giljahn, R M Slocumb, R E Espinoza, F Khan, K G Aird, T Beran, J J Rubertone, S J Slack, L Garcia, D L Rousseau, T A Janes, S M Schwartz, S W Bolick, D M Hurley, M A Whiteside, P Miller-Gianturco, M A Williams, K Herget, C Sweeney, A T Johnson, M B Keitheri Cheteri, P Migliore Santiago, S E Blankenship, S Farley, R Borchers, R Malicki, J R Espinoza, J Grandpre, H K Weir, R Wilson, B K Edwards, A Mariotto. Y Lei, N Wang, J S Chen, Y Zhou, Y T He, G H Song, X P Gu, D Mei, H J Mu, H M Ge, T H Wu, Y Y Li, D L Zhao, F Jin, J H Zhang, F D Zhu, Q Junhua, Y L Yang, C X Jiang, W Biao, J Wang, Q L Li, H Yi, X Zhou, J Dong, W Li, F X Fu, S Z Liu, J G Chen, J Zhu, Y H Li, Y Q Lu, M Fan, S Q Huang, G P Guo, H Zhaolai, K Wei, W Q Chen, H Zeng, A V Demetriou, W K Mang, K C Ngan, A C Kataki, M Krishnatreya, P A Jayalekshmi, P Sebastian, A Nandakumar, R Malekzadeh, G Roshandel, L Keinan-Boker, B G Silverman, H Ito, H Nakagawa, M Sato, F Tobori, I Nakata, N Teramoto, M Hattori, Y Kaizaki, F Moki, H Sugiyama, M Utada, M Nishimura, K Yoshida, K Kurosawa, Y Nemoto, H Narimatsu, M Sakaguchi, S Kanemura, M Naito, R Narisawa, I Miyashiro, K Nakata, S Sato, M Yoshii, I Oki, N Fukushima, A Shibata, K Iwasa, C Ono, T Matsuda, O Nimri, K W Jung, Y J Won, E Alawadhi, A Elbasmi, A Ab Manan, F Adam, E Sanjaajmats, U Tudev, C Ochir, A M Al Khater, M M El Mistiri, G H Lim, Y Y Teo, C J Chiang, W C Lee, R Buasom, S Sangrajrang, S Kamsaard, S Wiangnon, K Daoprasert, D Pongnikorn, A Leklob, S Sangkitipaiboon, S L Geater, H Sriplung, O Ceylan, I Kög, O Dirican, T Köse, T Gurbuz, F E Karaşahin, D Turhan, U Aktaş, Y Halat, S Eser, C I Yakut, M Altinisik, Y Cavusoglu, A Türkköylü, N Üçüncü, M Hackl, A A Zborovskaya, O V Aleinikova, K Henau, L Van Eycken, Z Valerianova, M R Yordanova, M Šekerija, L Dušek, M Zvolský, G Engholm, H Storm, K Innos, M Mägi, N Malila, K Seppä, J Jégu, M Velten, E Cornet, X Troussard, A M Bouvier, A V Guizard, V Bouvier, G Launoy, P Arveux, M Maynadié, M Mounier, A S Worono, M Daoulas, M Robaszkiewicz, J Clavel, S Goujon, B Lacour, I Baldi, C Pouchieu, B Amadeo, G Coureau, A Monnereau, S Orazio, P M Preux, F Rharbaoui, E Marrer, B Trétarre, M Colonna, P Delafosse, K Ligier, S Plouvier, A Cowppli-Bony, F Molinié, S Bara, O Ganry, B Lapôtre- Ledoux, P Grosclaude, N Bossard, Z Uhry, F Bray, M Piñeros, J Estève, R Stabenow, H Wilsdorf-Köhler, A Eberle, S Luttmann, I Löhden, A L Nennecke, J Kieschke, E Sirri, K Emrich, S R Zeissig, B Holleczek, N Eisemann, A Katalinic, R A Asquez, V Kumar, E Petridou, E J Ólafsdóttir, L Tryggvadóttir, K Clough-Gorr, P M Walsh, H Sundseth, G Mazzoleni, F Vittadello, E Coviello, F Cuccaro, R Galasso, G Sampietro, A Giacomin, M Magoni, A Ardizzone, A D'Argenzio, M Castaing, G Grosso, A M Lavecchia, A Sutera Sardo, G Gola, L Gatti, P Ricci, S Ferretti, D Serraino, A Zucchetto, M V Celesia, R A Filiberti, F Pannozzo, A Melcarne, F Quarta, A G Russo, G Carrozzi, C Cirilli, L Cavalieri d'Oro, M Rognoni, M Fusco, M F Vitale, M Usala, R Cusimano, W Mazzucco, M Michiara, P Sgargi, L Boschetti, E Borciani, P Seghini, M M Maule, F Merletti, R Tumino, P Mancuso, M Vicentini, T Cassetti, R Sassatelli, F Falcini, S Giorgetti, A L Caiazzo, R Cavallo, R Cesaraccio, D R Pirino, M L Contrino, F Tisano, A C Fanetti, S Maspero, S Carone, A Mincuzzi, G Candela, T Scuderi, M A Gentilini, S Pier, S Rosso, A Barchielli, A Caldarella, F Bianconi, F Stracci, P Contiero, G Tagliabue, M Rugge, M Zorzi, S Beggiato, A Brustolin, F Berrino, G Gatta, M Sant, C Buzzoni, L Mangone, R Capocaccia, R De Angelis, R Zanetti, A Maurina, S Pildava, N Lipunova, I Vincerževskienė, D Agius, N Calleja, S Siesling, O Visser, Larønningen, B Møller, A Dyzmann-Sroka, M Trojanowski, S Góźdź, R Mężyk, T Mierzwa, L Molong, J Rachtan, S Szewczyk, J Błaszczyk, K Kępska, B Kościańska, K Tarocińska, M Zwierko, K Drosik, K M Maksimowicz, E Purwin-Porowska, E Reca, J Wójcik-Tomaszewska, A Tukiendorf, M Grądalska-Lampart, A U Radziszewska, A Gos, M Talerczyk, M Wyborska, J A Didkowska, U Wojciechowska, M Bielska-Lasota, G Forjaz de Lacerda, R A Rego, J Bastos, M A Silva, L Antunes, J Laranja Pontes, A Mayer-da-Silva, A Miranda, L M Blaga, D Coza, Russia: M Y Valkov, L Gusenkova, O Lazarevich, O Prudnikova, D M Vjushkov, A G Egorova, A E Orlov, L A Kudyakov, L V Pikalova, J Adamcik, C Safaei Diba, M Primic-Žakelj, V Zadnik, N Larrañaga, A Lopez de Munain, A A Herrera, R Redondas, R Marcos-Gragera, M L Vilardell Gil, E Molina, M J Sánchez Perez, P Franch Sureda, M Ramos Montserrat, M D Chirlaque, C Navarro, E E Ardanaz, M M Guevara, R Fernández-Delgado, R Peris-Bonet, M Carulla, J Galceran, C Alberich, M Vicente-Raneda, S Khan, D Pettersson, P Dickman, I Avelina, K Staehelin, B Camey, C Bouchardy, R Schaar, H Frick, C Herrmann, J L Bulliard, M Maspoli-Conconi, C E Kuehni, S M Redmond, A Bordoni, L Ortelli, A Chiolero, I Konzelmann, K L Matthes, S Rohrmann, Broggio, J Rashbass, D Fitzpatrick, A Gavin, D I Clark, A J Deas, D W Huws, C White, C Allemani, A Bonaventure, M P Coleman, V Di Carlo, R Harewood, M Matz, L Montel, M Nikšić, B Rachet, A D Turculeț, R Stephens, C A Stiller, E Chalker, H Phung, R Walton, H You, S Guthridge, F Johnson, J Aitken, P Gordon, K D'Onise, K Priest, B C Stokes, A Venn, H Farrugia, V Thurs eld, J Dowlin, D Currow, J Hendrix, C Lewis
Subjects: 0301 basic medicine, Universal Health Coverage, population-based registries, Relative Survival, Settore MED/42 - Igiene Generale E Applicata, Cancer -- Treatment, Humans, Neoplasms, Population Surveillance, Registries, Survival Rate, Medicine (all), 0302 clinical medicine, cancer survival, education.field_of_study, Relative survival, EPICENE, General Medicine, 3. Good health, trend, 030220 oncology & carcinogenesis, Public-Health, cancer surveillance, Liver cancer, survival, cancer registry, CONCORD-3, Cure, Childhood-Cancer, medicine.medical_specialty, population-based cancer registries, Womens Cancers, Population, Medicine (all),cancer survival, population-based cancer registries, Socio-culturale, United-States, Article, 03 medical and health sciences, Breast cancer, Cancer epidemiology, medicine, Nordic-Countries, Cancer -- Mortality, education, Survival rate, Cancer prevention, Alternative Approach, business.industry, Public health, Cancer, Cancer -- Patients -- Long-term care, medicine.disease, 030104 developmental biology, High-Income Countries, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Demography
Abstract: Eser, Sultan (Balikesir Author), Background In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014. Methods CONCORD-3 includes individual records for 37.5 million patients diagnosed with cancer during the 15-year period 2000-14. Data were provided by 322 population-based cancer registries in 71 countries and territories, 47 of which provided data with 100% population coverage. The study includes 18 cancers or groups of cancers: oesophagus, stomach, colon, rectum, liver, pancreas, lung, breast (women), cervix, ovary, prostate, and melanoma of the skin in adults, and brain tumours, leukaemias, and lymphomas in both adults and children. Standardised quality control procedures were applied; errors were rectified by the registry concerned. We estimated 5-year net survival. Estimates were age-standardised with the International Cancer Survival Standard weights.Findings For most cancers, 5-year net survival remains among the highest in the world in the USA and Canada, in Australia and New Zealand, and in Finland, Iceland, Norway, and Sweden. For many cancers, Denmark is closing the survival gap with the other Nordic countries. Survival trends are generally increasing, even for some of the more lethal cancers: in some countries, survival has increased by up to 5% for cancers of the liver, pancreas, and lung. For women diagnosed during 2010-14, 5-year survival for breast cancer is now 89.5% in Australia and 90.2% in the USA, but international differences remain very wide, with levels as low as 66.1% in India. For gastrointestinal cancers, the highest levels of 5-year survival are seen in southeast Asia: in South Korea for cancers of the stomach (68.9%), colon (71.8%), and rectum (71.1%); in Japan for oesophageal cancer (36.0%); and in Taiwan for liver cancer (27.9%). By contrast, in the same world region, survival is generally lower than elsewhere for melanoma of the skin (59.9% in South Korea, 52.1% in Taiwan, and 49.6% in China), and for both lymphoid malignancies (52.5%, 50.5%, and 38.3%) and myeloid malignancies (45.9%, 33.4%, and 24.8%). For children diagnosed during 2010-14, 5-year survival for acute lymphoblastic leukaemia ranged from 49.8% in Ecuador to 95.2% in Finland. 5-year survival from brain tumours in children is higher than for adults but the global range is very wide (from 28.9% in Brazil to nearly 80% in Sweden and Denmark). Interpretation The CONCORD programme enables timely comparisons of the overall effectiveness of health systems in providing care for 18 cancers that collectively represent 75% of all cancers diagnosed worldwide every year. It contributes to the evidence base for global policy on cancer control. Since 2017, the Organisation for Economic Co-operation and Development has used findings from the CONCORD programme as the official benchmark of cancer survival, among their indicators of the quality of health care in 48 countries worldwide. Governments must recognise population-based cancer registries as key policy tools that can be used to evaluate both the impact of cancer prevention strategies and the effectiveness of health systems for all patients diagnosed with cancer., American Cancer Society Centers for Disease Control and Prevention Swiss Re Swiss Cancer Research foundation Swiss Cancer League Institut National du Cancer La Ligue Contre le Cancer Rossy Family Foundation US National Cancer Institute Susan G Komen Foundation
Published: 2018
Full Text: View/download PDF

4. La gestione del piede torto

Author: A. M. C. Galimberti, D Dibello, V Di Carlo, M Carbone, E Barbi, Galimberti, A. M. C., Dibello, D, Di Carlo, V, Carbone, M, and Barbi, E
Subjects: Congenital club foot, Classification, Conservative management
Abstract: Club foot (also called talipes equinovarus) is the commonest foot congenital malformation. It affects 1-2/1,000 of live births, showing a ratio M:F of 2:1 and a predominant distribution in the developing countries (80%). It is a complex and bilateral deformity in 50% of cases. Affected children will not walk physiologically and live a normal life without a proper treatment. Over the last decades corrective solutions with different degrees of invasiveness have been proposed. In particular, the surgical treatment of club foot may lead to complications and to the final result of a foot that hardly has a complete functionality also because of retractions and surgical scars. In the last decades scientific evidence has definitively confirmed the effectiveness of the Ponseti non-invasive method based on manipulation, plaster casts, percutaneous Achilles tenotomy and stabilisation of the foot using a brace.
Published: 2019

5. Investigation into ultrathin CdTe solar cell Voc using SCAPS modelling

Author: Andrew Clayton, Giray Kartopu, Vincent Barrioz, Stuart J. C. Irvine, D.A. Lamb, and V. Di Carlo
Subjects: Materials science, Open-circuit voltage, business.industry, Mechanical Engineering, Photovoltaic system, Nanotechnology, Chemical vapor deposition, Condensed Matter Physics, Cadmium telluride photovoltaics, law.invention, Mechanics of Materials, Saturation current, Photovoltaics, law, Solar cell, Optoelectronics, General Materials Science, Metalorganic vapour phase epitaxy, business
Abstract: Ultrathin CdTe photovoltaic solar cells were produced by metal organic chemical vapour deposition in a single horizontally configured growth chamber. Solar cell activation was investigated by varying the duration of the CdCl2 layer deposition and 420°C thermal anneal to promote Cl diffusion into the CdTe. Thicker CdCl2 layers used in activation treatment resulted in a greater degree of sulphur interdiffusion, up to 2 at.-%, into the CdTe layer. The thicker CdCl2 activation layer was necessary to lower the reverse saturation current density for obtaining optimum experimental photovoltaic (PV) device performances. Modelling of the PV performances with equivalent solar cell structure for optimised devices using solar cell capacitance simulation software resulted in an overestimated open circuit voltage (Voc). The simulations showed that reduced acceptor states at the CdTe interface with the intermixed region resulted in the largest decrease in Voc when considering large back surface recombination velocities.
Published: 2014
Full Text: View/download PDF

6. Prognostic value of carbohydrate antigen (CA) 19-9 decrease in response to chemotherapy for advanced pancreatic adenocarcinoma (PA)

Author: Cereda, S (Cereda, S.)[ 1 ], Rognone, A (Rognone, A.)[ 1 ], Mazza, E (Mazza, E.)[ 1 ], Passoni, P (Passoni, P.)[ 1 ], Zerbi, A (Zerbi, Balzano, G (Balzano, G.)[ 1 ], Nicoletti, R (Nicoletti, R.)[ 1 ], Arcidiacono P.G., Di Carlo, V (Di Carlo, V.)[ 1 ], Reni, M (Reni, M.)[ 1 ], Cereda, S, (Cereda, Stefano)[, 1 ], Rognone, A, (Rognone, Alessia)[, 1 ], Mazza, E, (Mazza, Elena)[, 1 ], Passoni, P, (Passoni, Paolo)[, 1 ], Zerbi, A, (Zerbi, Alessandro)[, 1 ], Balzano, G, (Balzano, Gianpaolo)[, 1 ], Nicoletti, R, (Nicoletti, Roberto)[, 1 ], Arcidiacono, P. G., Di, Carlo, V (Di, Carlo, Valerio)[, 1 ], Reni, M, (Reni, Michele)[, 1 ], (Cereda, S, [ 1 ], S., (Rognone, A, [ 1 ], A., (Mazza, E, [ 1 ], E., (Passoni, P, [ 1 ], P., (Zerbi, A, (Balzano, G, [ 1 ], G., (Nicoletti, R, [ 1 ], R., Carlo, Di, V (Di Carlo, [ 1 ], V., (Reni, M, and [ 1 ], M.
Published: 2007

7. Worldwide trends in survival from adult glioma 2000-2014 (CONCORD-3): Impact of morphology

Author: F. Girardi, V. Di Carlo, A. Bonaventure, C. Allemani, M.P. Coleman, and C.O.N.C.O.R.D. Working
Subjects: Pathology, medicine.medical_specialty, Oncology, business.industry, Glioma, medicine, Morphology (biology), Hematology, business, medicine.disease
Published: 2018
Full Text: View/download PDF

8. Worldwide comparison of colorectal cancer survival by topography and stage at diagnosis (CONCORD-2)

Author: V. Di Carlo, Maja Niksic, Claudia Allemani, Michel P Coleman, and S. Benitez Majano
Subjects: Oncology, medicine.medical_specialty, business.industry, Colorectal cancer, Internal medicine, medicine, Hematology, business, medicine.disease, Stage at diagnosis
Published: 2018
Full Text: View/download PDF

9. Worldwide trends in survival from childhood glioma 2000-2014 (CONCORD-3): Preliminary findings and plans for further research

Author: Fabio Girardi, Audrey Bonaventure, Claudia Allemani, Michel P Coleman, and V. Di Carlo
Subjects: Oncology, medicine.medical_specialty, business.industry, Internal medicine, Glioma, medicine, Hematology, medicine.disease, business
Published: 2018
Full Text: View/download PDF

10. Effect of hospital volume on outcome of pancreaticoduodenectomy in Italy

Author: V. Di Carlo, Alessandro Zerbi, Giovanni Capretti, Gianpaolo Balzano, Vanessa Capitanio, and S. Rocchetti
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Treatment outcome, Hospital mortality, Pancreaticoduodenectomy, Hospital volume, Pancreatitis, Chronic, medicine, Humans, Hospital Mortality, Aged, Health Facility Size, business.industry, Mortality rate, Odds ratio, Length of Stay, Surgery, Pancreatic Neoplasms, Low volume, Treatment Outcome, Italy, Multicenter study, Female, business
Abstract: Background An inverse relationship between hospital volume and death following pancreatico duodenectomy (PD) has been reported from several countries. The aim of this study was to assess the volume–outcome effect of PD in Italy. Methods The study group comprised 1576 patients who underwent PD in 2003. Hospitals were allocated to four volume groups: low volume, five PDs or fewer; medium volume, six to 13 PDs; high volume, 14 to 51 PDs; and very high volume, two hospitals that performed 89 and 104 PDs. Results Some 221 hospitals performed at least one PD in 2003; hospital volume was low in 74·7 per cent, medium in 17·6 per cent, high in 6·8 per cent and very high in 0·9 per cent. The overall mortality rate was 8·1 per cent. Increasing hospital volume was associated with a significantly reduced mortality rate: 12·4 per cent (adjusted odds ratio (OR) 1·000) for low-volume, 7·8 per cent (OR 0·611) for medium-volume, 5·9 per cent (OR 0·466) for high-volume and 2·6 per cent (OR 0·208) for very high-volume hospitals. Length of postoperative stay was reduced in very high-volume hospitals (P < 0·001). Conclusion The outcome of PD in Italy is dependent on hospital volume and a policy of centralization may therefore be appropriate.
Published: 2007
Full Text: View/download PDF

11. Arterial vs pancreatic phase: which is the best choice in the evaluation of pancreatic endocrine tumours with multidetector computed tomography (MDCT)?

Author: Simone Gusmini, Luca Albarello, C. Caborni, Roberto Nicoletti, F. De Cobelli, S. I. Rocchetti, A. Del Maschio, Alessandro Zerbi, Carlo Martinenghi, V. Di Carlo, Paolo Giorgio Arcidiacono, and G. Balzano
Subjects: Adult, Male, medicine.medical_specialty, Endosonography, Islets of Langerhans, Insulin-Secreting Cells, Cytology, medicine, Humans, Endocrine system, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, Neuroradiology, Aged, 80 and over, medicine.diagnostic_test, business.industry, Biopsy, Needle, Liver Neoplasms, Ultrasound, Interventional radiology, General Medicine, Middle Aged, Immunohistochemistry, Spiral computed tomography, Pancreatic Neoplasms, medicine.anatomical_structure, Glucagon-Secreting Cells, Data Interpretation, Statistical, Female, Radiology, Pancreas, business, Tomography, Spiral Computed
Abstract: The aim of this study was to assess whether the pancreatic phase may replace the arterial phase in the evaluation of endocrine pancreatic tumours.Twenty-nine endocrine pancreatic lesions with definitive morphological and immunohistochemical characterisation after surgical treatment (n=24) or fine-needle-aspiration cytology under endoscopic ultrasonography guidance (n=5) were retrospectively evaluated. All lesions were studied with triple-phase 16-row multidetector computed tomography (MDCT). Images obtained during each phase were separately interpreted by two senior radiologists experienced in pancreatic pathology and who were blinded to surgical results. Endocrine tumour and normal pancreas attenuation and the mean absolute tumour-to-gland attenuation difference were measured in each phase, and data were analysed with Student's t test. Visualisation of arterial vascular abnormalities and hypervascular liver metastases in the arterial and pancreatic phases and the diagnostic contribution of the two phases were compared.For both radiologists, the mean absolute tumour-to-gland attenuation difference was significantly higher (p0.05) in the pancreatic phase (40+/-53 HU and 34+/-56 HU) than in the arterial phase (31+/-38 HU and 26+/-43 HU). There were no differences in the detection of arterial vascular abnormalities or hypervascular liver metastases in the two phases. The diagnostic contribution was higher in the pancreatic phase.In our experience, the pancreatic phase can replace the arterial phase in the evaluation of pancreatic endocrine tumours.
Published: 2007
Full Text: View/download PDF

12. Midterm results of mobile-bearing knee replacements

Author: R. Gabrieli, V. Di Carlo, F. Specchiulli, and D. Borsetti
Subjects: musculoskeletal diseases, Knee arthritis, medicine.medical_specialty, Sports medicine, Original, business.industry, Radiography, medicine.medical_treatment, Osteoarthritis, musculoskeletal system, medicine.disease, Prosthesis, Surgery, Prothesis, Orthopedic surgery, medicine, Orthopedics and Sports Medicine, Implant, business
Abstract: We examined the clinical and radiographic results of 93 patients affected by knee arthritis or osteonecrosis subjected to unilateral cementless mobile-bearing total knee arthroplasty with the LCS prothesis (Depuy/Johnson & Johnson). The mean follow-up was 9.5 years (range, 7–12 years). Clinical evaluation was performed using the Knee Society rating system, while radiographic evaluation was done according to the Knee Society roentgenographic system. At the latest follow-up, the mean knee score was 87 points: the functional score improved from 40 to 90. Radiolucent lines were small and not progressive. The implant survival at 12 years was 88%. Six knees (7%) required revision for implant-related problems. We conclude that the mobile-bearing prosthesis is a successful device even at long-term follow-up.
Published: 2007
Full Text: View/download PDF

13. Peritalar dislocations

Author: F. Specchiulli, R. Gabrieli, V. Di Carlo, and B. Maiorana
Subjects: Orthopedics and Sports Medicine, Podiatry
Published: 2007
Full Text: View/download PDF

14. Dose-Intense PEFG (Cisplatin, Epirubicin, 5-Fluorouracil, Gemcitabine) in Advanced Pancreatic Adenocarcinoma: A Dose-Finding Study

Author: V. Di Carlo, Michele Reni, Stefano Cereda, Maria Grazia Viganò, E. Bonetto, Roberto Nicoletti, Paolo Passoni, Carlo Staudacher, Gianpaolo Balzano, Alessandro Zerbi, Reni, M, Cereda, S, Bonetto, E, Vigano, Mg, Passoni, P, Zerbi, A, Balzano, G, Nicoletti, R, Staudacher, C, and Di Carlo, V
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Maximum Tolerated Dose, medicine.medical_treatment, Urology, Adenocarcinoma, Deoxycytidine, Drug Administration Schedule, Internal medicine, Pancreatic cancer, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Aged, Epirubicin, Cisplatin, Chemotherapy, business.industry, General Medicine, Middle Aged, Metastatic Pancreatic Adenocarcinoma, medicine.disease, Gemcitabine, Pancreatic Neoplasms, Regimen, Female, Fluorouracil, business, medicine.drug
Abstract: The aim of this study was to assess the maximum tolerated dose (MTD) of an intensified PEFG regimen administered every 14 days to patients with Stage III or metastatic pancreatic adenocarcinoma. Twenty-nine patients received fixed doses of both epirubicin (30 mg/m(2)) and 5-fluorouracil (200 mg/m(2)/day on Days 1-14) and of escalating doses of cisplatin and gemcitabine. The MTD was cisplatin 30 mg/m(2) and gemcitabine 800 mg/m(2). With respect to classical PEFG, intensified regimen potentially improved the dose-intensity of both cisplatin and epirubicin by 50 percent and of gemcitabine by 33 percent, reduced Grade 3-4 haematological toxicity and the number of outpatient accesses.
Published: 2007
Full Text: View/download PDF

15. Ultrastructural Changes in Canine Lung Allografts

Author: G Bevilacqua, V. Staudacher, V. Di Carlo, E. Sibilla, Carlo Staudacher, and G. Bragherio
Subjects: Pathology, medicine.medical_specialty, Lung, medicine.anatomical_structure, business.industry, Ultrastructure, Medicine, business
Published: 2015
Full Text: View/download PDF

16. Raltitrexed–eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer

Author: Lorenzo Piemonti, Paolo Passoni, Michele Reni, Roberto Nicoletti, L. M. Pasetto, Alba A. Brandes, Gabriele Luppi, Clara Fugazza, Alessandro Zerbi, V. Di Carlo, Giuseppe Aprile, Stefania Dell'Oro, Carlo Milandri, Stefano Cordio, E. Bonetto, Gianpaolo Balzano, Reni, M, Pasetto, L, Aprile, G, Cordio, S, Bonetto, E, Dell'Oro, S, Passoni, P, Piemonti, Lorenzo, Fugazza, C, Luppi, G, Milandri, C, Nicoletti, R, Zerbi, A, Balzano, G, Di Carlo, V, and Brandes, Aa
Subjects: Adult, Male, Cancer Research, medicine.medical_specialty, Pancreatic disease, Organoplatinum Compounds, pancreatic cancer, Salvage therapy, Thiophenes, chemotherapy, Deoxycytidine, Gastroenterology, Pancreatic cancer, Internal medicine, Clinical Studies, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, salvage therapy, Neoplasm Metastasis, Infusions, Intravenous, Aged, Aged, 80 and over, Performance status, business.industry, oxaliplatin, raltitrexed, Middle Aged, Metastatic Pancreatic Adenocarcinoma, medicine.disease, Survival Analysis, Gemcitabine, Surgery, Pancreatic Neoplasms, Regimen, Oncology, Drug Resistance, Neoplasm, Disease Progression, Quality of Life, Quinazolines, Female, business, metastatic disease, Raltitrexed, medicine.drug
Abstract: Limited information on salvage treatment in patients affected by pancreatic cancer is available. At failure, about half of the patients present good performance status ( PS) and are candidate for further treatment. Patients > 18 years, PS >= 50, with metastatic pancreatic adenocarcinoma previously treated with gemcitabine- containing chemotherapy, and progression- free survival ( PFS) < 12 months received a combination of raltitrexed ( 3 mgm (-2)) and oxaliplatin ( 130 mgm (-2)) every 3 weeks until progression, toxicity, or a maximum of six cycles. A total of 41 patients received 137 cycles of chemotherapy. Dose intensity for both drugs was 92% of the intended dose. Main grade 42 toxicity was: neutropenia in five patients ( 12%), thrombocytopenia, liver and vomiting in three ( 7%), fatigue in two ( 5%). In total, 10 patients ( 24%) yielded a partial response, 11 a stable disease. Progression- free survival at 6 months was 14.6%. Median survival was 5.2 months. Survival was significantly longer in patients with previous PFS 46 months and in patients without pancreatic localisation. A clinically relevant improvement of quality of life was observed in numerous domains. Raltitrexed oxaliplatin regimen may constitute a treatment opportunity in gemcitabine- resistant metastatic pancreatic cancer. Previous PFS interval may allow the identification of patients who are more likely to benefit from salvage treatment.
Published: 2006
Full Text: View/download PDF

17. Evaluation of recombinant human erythropoietin to facilitate autologous blood donation before surgery in anaemic patients with cancer of the gastrointestinal tract

Author: Luca Gianotti, Oreste Gentilini, P Servida, A. Vignali, C Bordignon, Marco Braga, V. Di Carlo, Braga, Marco, Gianotti, L, Vignali, Andrea, Gentilini, O, Servida, P, Bordignon, Claudio, Dicarlo, V., Braga, M., Gianotti, L., Gentilini, O., Servida, P., V., Di Carlo, Braga, M, Vignali, A, Bordignon, C, and Di Carlo, V
Subjects: Adult, Male, medicine.medical_specialty, Blood transfusion, Adolescent, Anemia, medicine.medical_treatment, Hematocrit, Iron sucrose, Blood Transfusion, Autologous, Stomach Neoplasm, Stomach Neoplasms, Preoperative Care, medicine, Humans, Prospective Studies, Elective surgery, Prospective cohort study, Erythropoietin, Aged, Colonic Neoplasm, Rectal Neoplasm, Anemia, Iron-Deficiency, medicine.diagnostic_test, Rectal Neoplasms, business.industry, Perioperative, Recombinant Protein, Middle Aged, medicine.disease, Recombinant Proteins, Surgery, Prospective Studie, Blood Transfusion, Autologou, Colonic Neoplasms, Female, business, Human, medicine.drug
Abstract: The aim of this study was to determine whether the preoperative administration of recombinant human erythropoietin (rHuEPO) could increase the rate of autologous blood donation and reduce the perioperative need for homologous blood in anaemic patients with cancer. Twenty-two anaemic (haematocrit less than 34 per cent), iron-deficient (iron less than 700 µg/I) patients, with gastric or colorectal cancer scheduled for elective surgery, were allocated randomly to two groups. The first (n = 11) received iron saccharate 200 mg/day intravenously for 12 consecutive days. The second (n = 11) received rHuEPO subcutaneously (300 units/kg as first administration, and 100 units/kg 4, 8 and 12 days later) with supplemental iron. On days 4, 8 and 12, if the haematocrit was greater than 34 per cent, patients donated one unit (350 ml) of autologous blood. In the iron group the mean haematocrit did not change from admission (31 per cent) to day 12 of treatment (31 per cent), and no patient could donate autologous blood. In the rHuEPO group, eight patients donated two units of autologous blood and three donated one unit. Four patients in the iron group received perioperative transfusion of homologous blood compared with none in the rHuEPO group. Administration of rHuEPO facilitated the donation of autologous blood and reduced perioperative homologous blood transfusion in anaemic patients with cancer.
Published: 1995
Full Text: View/download PDF

18. Hemofiltration for Cytokine-Driven Illnesses: The Mediator Delivery Hypothesis

Author: Steven R. Alexander and J V Di Carlo
Subjects: medicine.medical_treatment, 030232 urology & nephrology, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, 030204 cardiovascular system & hematology, Systemic inflammation, Capillary Permeability, Biomaterials, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Immune system, Body Water, Hemofiltration, medicine, Humans, Hyaluronic Acid, Kidney, business.industry, Membranes, Artificial, General Medicine, Mononuclear phagocyte system, medicine.disease, medicine.anatomical_structure, Lymphatic system, Cytokine, Immunology, Cytokines, medicine.symptom, Extracellular Space, business
Abstract: Hemofiltration is evolving as an adjunctive therapy for sepsis and other forms of systemic inflammation. Designed as a substitute for lost renal function, it is sometimes employed prior to the onset of renal failure to facilitate the nonspecific clearance of pro-inflammatory mediators. Prevailing theories suggest that hemofiltration attenuates the immune response when a threshold amount of excess cytokine is removed at the semi-permeable membrane. In this article we introduce an alternative hypothesis, in which hemofiltration exerts its effect by reinvigorating lymphatic flow and function. Crystalloid “replacement” solution, as much as 48 to 72 liters daily, is infused to restore intravascular volume lost through production of ultrafiltrate. Partial redistribution into interstitium and lymph mobilizes inflammatory mediators and other proteins, cellular byproducts, excessive ground matrix, fragments of apoptotic cells and free DNA. These substances are then metabolized, scavenged or cleared at multiple sites, including the reticuloendothelial system, liver, kidney, erythrocyte, and hemofilter.
Published: 2005
Full Text: View/download PDF

19. Long-Term survival after kidney and Kidney–Pancreas transplantation in diabetic patients

Author: Carlo Socci, Paolo Fiorina, L. Invernizzi, E. La Rocca, V. Zuber, M. Cristallo, Antonio Secchi, Paola Maffi, Elena Orsenigo, V. Di Carlo, Orsenigo, E, Fiorina, P, Cristallo, M, Socci, C, La Rocca, E, Maffi, P, Invernizzi, L, Zuber, V, Secchi, Antonio, and Di Carlo, V.
Subjects: Graft Rejection, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Urology, Peritoneal dialysis, Diabetic nephropathy, Diabetes mellitus, medicine, Humans, Diabetic Nephropathies, Survivors, Treatment Failure, Renal replacement therapy, Dialysis, Kidney transplantation, Retrospective Studies, Transplantation, business.industry, Middle Aged, medicine.disease, Kidney Transplantation, Survival Analysis, Surgery, Diabetes Mellitus, Type 1, Kidney Failure, Chronic, Pancreas Transplantation, Hemodialysis, business, Follow-Up Studies
Abstract: Purpose To investigate the influence of diabetes mellitus on patient and graft survival among renal versus renal–pancreatic recipients. Methods Among 270 renal transplants performed from 1985 to 2002, a total of 204 (75%) were in diabetic patients and 66 (25%) in nondiabetic patients. Among the 204 diabetic patients 161 (60%) kidneys were transplanted simultaneously with a pancreatic graft (SKPT group). The overall group of patient included 164 (61%) men and 106 (39%) women with mean time on dialysis of 31 ± 21 months (range 0 to 126 months). The mean duration of diabetes was 24 ± 7 years (range 5 to 51 years). Ninety-nine percent of the patients were on renal replacement therapy (79% hemodialysis and 20% peritoneal dialysis). Results The overall rejection rate was similar (NS). Both patient and kidney graft survival rates were worse in diabetics. Patient survival was 82% at 5 years among patients undergoing SKPT, 60% in diabetics receiving only a kidney, and 88% in nondiabetic transplanted patients. Kidney graft survival at 5 years was 77% in diabetics receiving SKPT, 68% in diabetics receiving a kidney alone, and 82% in nondiabetic patients. Overall patient survival was significantly greater among nondiabetics (P = .002) or in diabetics who received SKPT compared with diabetics who only had a kidney transplant (P = .001). Conclusions This retrospective clinical evaluation confirms that combined pancreas and kidney transplantation should be the first choice to insulin-dependent diabetes mellitus (IDDM) patients with end-stage diabetic nephropathy.
Published: 2004
Full Text: View/download PDF

20. Behavior of tumor markers CA19.9, CA195, CAM43, CA242, and TPS in the diagnosis and follow-up of pancreatic cancer

Author: S Pastori, V. Di Carlo, D. Parolini, Pierangelo Bonini, Giuseppe Banfi, Alessandro Zerbi, Banfi, Giuseppe, A., Zerbi, S., Pastori, D., Parolini, V., Di Carlo, and P., Bonini
Subjects: Adult, Male, Carbohydrate, medicine.medical_specialty, Pathology, Pancreatic disease, Tissue Polypeptide Antigen, Tumor Marker, Clinical Biochemistry, Biology, Gastroenterology, Antigen, Internal medicine, Pancreatic cancer, Biomarkers, Tumor, medicine, Carcinoma, Humans, Antigens, Tumor-Associated, Carbohydrate, False Positive Reactions, Stage (cooking), Neoplasm Staging, Aged, Epithelioma, Tumor-Associated, Biochemistry (medical), Pancreatic Neoplasm, False Positive Reaction, Middle Aged, Biological, medicine.disease, Pancreatic Neoplasms, Peptide, Female, CA19-9, Peptides, Human
Abstract: We compared the recently proposed tumor markers CA195, CA242, and CAM43 with a widely used antigen, CA19.9, and a circulating marker of cellular proliferation, TPS, to define their specificity, sensitivity, and cost-benefit ratio. The tumor markers were measured in 41 pancreatic carcinoma patients and in two control groups, the first comprising 19 patients with benign pancreatic diseases, the second comprising 41 healthy blood donors. Sensitivities were 79% for CA19.9, 57% for CA242, 60% for CAM43, 76% for CA195, and 98% for TPS. Specificities calculated for the group with pancreatic diseases were 60% for CA19.9, 84% for CA242, 95% for CAM43, 53% for CA195, and 22% for TPS. Specificities for the blood donor group were 100% for CA19.9, 93% for CA242, 98% for CAM43, 85% for CA195, and 88% for TPS. Positive values for the tumor markers appeared from second stage (Hermreck classification). Metastases, invasion of lymph nodes, and coupling of cancer-associated antigens did not significantly modify marker sensitivity. In pancreatic carcinoma, CA19.9 showed good sensitivity (79%) and high specificity (60-100%). In view of their own advantages (e.g., high specificity of CAM43, high sensitivity of TPS in recurrences) and limits (e.g., low sensitivity of CAM43, very low sensitivity of TPS), the other markers could be used alone or with CA19.9. Two pairs of tumor markers showed high similarity in our study: CA19.9 and CA195, and CAM43 and CA242.
Published: 1993
Full Text: View/download PDF

21. Surgical Treatment of Benign and Borderline Neoplasms of the Pancreatic Body

Author: V. Di Carlo, M. Cristallo, P. Veronesi, Alessandro Zerbi, and Gianpaolo Balzano
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Fistula, Enucleation, Pancreatectomy, Diabetes mellitus, Occlusion, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Gastroenterology, Middle Aged, medicine.disease, Surgery, Pancreatic Neoplasms, Treatment Outcome, medicine.anatomical_structure, Pancreatic fistula, Female, Pancreas, business, Duct (anatomy)
Abstract: Background: Conventional operations for benign and borderline tumors of the pancreatic body are distal pancreatectomy and enucleation. An unusual operation allowing the preservation of the proximal and distal pancreas is median pancreatectomy. Method: A retrospective analysis of prospectively collected data on 67 patients with nonmalignant neoplasms of the pancreatic body was performed. The operations were: 32 median pancreatectomies (22 with duct occlusion of the distal pancreas, 10 with pancreaticojejunostomy), 21 distal pancreatectomies, and 14 enucleations. The operative and long-term outcomes of the different operations were compared. Results: Enucleation had a shorter operative time and less blood loss than the other operations. No mortality was observed. The pancreatic fistula rate was 50% after median pancreatectomy (59% in case of distal duct occlusion, 30% in case of pancreaticojejunostomy), 14% after distal pancreatectomy and 14% after enucleation. Diabetes appeared in 3 patients after distal pancreatectomy and 3 patients after median pancreatectomy with duct occlusion. Conclusions: When indicated, enucleation is the operation of choice for a nonmalignant neoplasm of the pancreatic body. With respect to distal resection, the higher fistula rate of median pancreatectomy with pancreaticojejunostomy could be the price for a better long-term endocrine function; median pancreatectomy with duct occlusion had worse operative results and no long-term advantages.
Published: 2003
Full Text: View/download PDF

22. Pratical guidelines for acute pancreatitis

Author: PEZZILLI, RAFFAELE, CASADEI, RICCARDO, FANTINI, MARIA PIA, DALLOLIO, LAURA, FABBRI, GIULIANA, MORSELLI LABATE, ANTONIO MARIA, CALCULLI, LUCIA, A. Zerbi, V. Di Carlo, C. Bassi, G. F. Delle Fave, Bassi, C, Castoldi, L, Rabitti, P, Balzano, G, Gaia, E, Mutignani, M, Uomo, G, Brazzi, L, D'Alessandro, A, Frulloni, L, Scarpellini, P, Gabbrielli, A, Del Chiaro, M, Mariani, A, De Rai, P, Billi, P, Casadei, R, Nicoletti, R, R. Pezzilli, A. Zerbi, V. Di Carlo, C. Bassi, G.F. Delle Fave, Working Group of the Italian Association for the Study of the Pancreas on Acute Pancreatitis […, Fantini, M P, Dallolio, L, Fabbri, G, Morselli-Labate, A M, Bassi, C, Calculli, L, Castoldi, L, Rabitti, P, Balzano, G, Gaia, E, Mutignani, M, Uomo, G, Brazzi, L, D'Alessandro, A, Frulloni, L, Scarpellini, P, Gabbrielli, A, Del Chiaro, M, Mariani, A, De Rai, P, Billi, P, Casadei, R, Nicoletti, R, and …]
Subjects: medicine.medical_specialty, acute pancreatitis, diagnosis, diagnostic imaging, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, pancreatitis, Gastroenterology, Basal (phylogenetics), Severity assessment, Enteral Nutrition, Internal medicine, medicine, therapeutics, Humans, In patient, Cholecystectomy, guidelines, pancreas, APACHE, acute pancreatiti, therapy, Analgesics, Hepatology, business.industry, Pancreatitis, Acute Necrotizing, disease management, pancreatic necrosis, prognosis, Alanine Transaminase, Lipase, medicine.disease, Surgery, Buprenorphine, Parenteral nutrition, Acute Disease, Etiology, Pancreatitis, Acute pancreatitis, business, Tomography, X-Ray Computed, guideline, management
Abstract: INTRODUCTION: The following is a summary of the official guidelines of the Italian Association for the Study of the Pancreas regarding the medical, endoscopic and surgical management of acute pancreatitis. STATEMENTS: Clinical features together with elevation of the plasma concentrations of pancreatic enzymes are the cornerstones of diagnosis (recommendation A). Contrast-enhanced computed tomography (CT) provides good evidence for the presence of pancreatiti (recommendation C) and it should be carried out 48-72 h after the onset of symptoms in patients with predicted severe pancreatitis. Severity assessment is essential for the selection of the proper initial treatment in the management of acute pancreatitis (recommendation A) and should be done using the APACHE II score, serum C-reactive protein and CT assessment (recommendation C). The etiology of acute pancreatitis should be able to be determined in at least 80% of cases (recommendation B). An adequate volume of intravenous fluid should be administered promptly to correct the volume deficit and maintain basal fluid requirements (recommendation A); analgesia is crucial for the correct treatment of the disease (recommendation A). Enteral feeding is indicated in severe necrotizing pancreatitis and it is better than total parenteral nutrition (recommendation A). The use of prophylactic broad-spectrum antibiotics reduces infection rates in CT-proven necrotizing pancreatitis (recommendation A). Infected pancreatic necrosis in patients with clinical signs and symptoms of sepsis is an indication for intervention, including surgery and radiological drainage (recommendation B). CONCLUSIONS: The participants agreed to revise the guidelines every 3 years in order to re-evaluate each question on the management of acute pancreatitis patients according to the most recent literature.
Published: 2010

23. Postabsorptive muscle protein metabolism in type 1 diabetic patients after pancreas transplantation

Author: Livio Luzi, V. Di Carlo, Guido Pozza, M. Spessot, L. Piceni Sereni, M. R. Pastore, Ileana Terruzzi, Antonio Secchi, M. Bianchi, R. Dodesini, and M. Cristallo
Subjects: Adult, Blood Glucose, medicine.medical_specialty, Phenylalanine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Protein metabolism, Muscle Proteins, Pancreas transplantation, Protein degradation, chemistry.chemical_compound, Endocrinology, Leucine, Reference Values, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Hyperinsulinemia, Humans, Insulin, Muscle, Skeletal, Glycated Hemoglobin, Type 1 diabetes, C-Peptide, business.industry, Proteins, General Medicine, Middle Aged, medicine.disease, Transplantation, Forearm, Diabetes Mellitus, Type 1, chemistry, Regional Blood Flow, Protein Biosynthesis, Cyclosporine, Prednisone, Pancreas Transplantation, Energy Intake, business, Immunosuppressive Agents
Abstract: Insulin was shown to induce protein anabolism in vivo mainly by inhibiting proteolysis. Heterotopic pancreas transplantation in type 1 diabetes mellitus is characterized by peripheral hyperinsulinemia due to systemic rather than portal insulin delivery. Therefore, we studied the postabsorptive muscle protein metabolism in type 1 diabetic patients with or without pancreas transplantation. The forearm balance technique was performed in 9 type 1 diabetic patients on exogenous insulin treatment, in 4 type 1 diabetic patients following successful pancreas transplantation and in 6 healthy volunteers. Labelled leucine and phenylalanine were infused to quantify whole-body and muscle protein synthesis, respectively. In the postabsorptive state, whole-body protein synthesis (leucine kinetics) was similar in pancreas-transplanted patients and controls. In contrast, muscle protein synthesis tended to be less negative in pancreas-transplanted patients with respect to type 1 diabetic patients and healthy volunteers. The present data suggest that recipients with peripheral insulin delivery and chronic hyperinsulinemia are characterized by a preferential stimulation of protein synthesis in muscle rather than in the splanchnic district. When insulin was infused acutely, while maintaining euglycemia, the whole-body and muscle protein synthesis rates were approximately halved in type 1 diabetic patients with and without pancreas transplantation. We conclude that pancreas transplantation is able to normalize basal and insulin-stimulated protein metabolism. Chronic hyperinsulinemia counteract steroid-induced protein degradation by means of a mild, but persistent stimulation of muscle protein synthesis.
Published: 2000
Full Text: View/download PDF

24. HEALTH CARE RESOURCES CONSUMED TO TREAT POSTOPERATIVE INFECTIONS: COST SAVING BY PERIOPERATIVE IMMUNONUTRITION

Author: Luca Gianotti, A Frei, R Greiner, V. Di Carlo, Marco Braga, Gianotti, L, Braga, M, Frei, A, Greiner, R, Di Carlo, V, Gianotti, L., Braga, Marco, Frei, A., Greiner, G., and DI CARLO, V.
Subjects: Male, medicine.medical_specialty, Total cost, Cost effectiveness, Cost-Benefit Analysis, Hospital Cost, Critical Care and Intensive Care Medicine, law.invention, Treatment and control groups, Postoperative Complications, Enteral Nutrition, Randomized controlled trial, law, medicine, Humans, Surgical Wound Infection, Hospital Costs, Cost-Benefit Analysi, Intensive care medicine, health care economics and organizations, Gastrointestinal Neoplasms, Aged, Food, Formulated, biology, business.industry, Postoperative complication, Euros, Cost-effectiveness analysis, Perioperative, Middle Aged, biology.organism_classification, Gastrointestinal Neoplasm, Emergency Medicine, Female, Postoperative Complication, business, Human
Abstract: The objectives of the study were to calculate the costs of postoperative complications and to evaluate whether the use of perioperative enteral immunonutrition, may lead to a saving in health care resources consumed. The economic analysis was based on data from a randomized double-blind trial that include 206 cancer patients who received perioperatively either enteral immunonutrition (treatment group, n = 102) or a standard enteral diet (control group, n = 104). Estimates of costs were based on resource use for treatment of complications, which were valued according to the National List of Sanitary Costs of the Italian Ministry of Health and on the medical Diagnosis-Related-Group (DRG) reimbursement rates. Costs of nutrition were also calculated. Cost comparison and cost effectiveness analyses were then carried out. Intent-to-treat analysis showed that the total costs of 52 postoperative complications were 322,218 euros, with a consumption of the DRG reimbursement rate of 15.4%. The costs of nutrition were 35,437 euros in the treatment group versus 10,768 euros in the control group. The total costs (nutrition plus treating complications) amounted to 113,778 euros in the treatment group versus 254,450 euros in the control group. The mean total costs per patient were 1,115 euros in the treatment group versus 2,447 euros in the control group (P = 0.04). Effectiveness was 83.3% in the treatment group versus 68.3% in the control group (P = 0.009). Cost effectiveness analysis showed a net saving of 2,386 euros per complication-free patient in favor of the treatment group. In conclusion, the perioperative use of immunonutrition appears cost effective due to a substantial saving of resources used to treat postoperative complications.
Published: 2000
Full Text: View/download PDF

25. Effect of hemipancreatectomy and of pancreatic diversion on the tolerance to a glucose load in humans

Author: Alberto Battezzati, Livio Luzi, Andrea Caumo, V. Di Carlo, Gianluca Perseghin, Alessandro Zerbi, and Ileana Terruzzi
Subjects: endocrine system, medicine.medical_specialty, business.industry, medicine.medical_treatment, Insulin, Glucose uptake, Clinical Biochemistry, General Medicine, Pancreas transplantation, medicine.disease, Biochemistry, Insulin oscillation, Pathogenesis, Impaired glucose tolerance, medicine.anatomical_structure, Endocrinology, Internal medicine, Pancreatectomy, medicine, Pancreas, business
Abstract: Background The role of the pattern, quantity and site of insulin secretion in the tolerance to a glucose challenge is not fully evaluated in humans because it is difficult to obtain appropriate clinical models. Design To address this issue, we studied subjects with reduced pancreatic mass (hemipancreatectomized, HEMI), systemic insulin delivery (pancreas transplant recipients, PTX), and two control groups (healthy, CON; and with uveitis on the same immunosuppression as PTX, UVE), with an hyperglycaemic clamp (study 1, + 4.2 mmol L−1), using a repeat experiment (study 2) with a fixed glucose infusion, calculated to increase by 35% that in study 1. Results In study 1, CON increased glucose uptake to 20 ± 3 μmol kg−1 min−1 after a biphasic insulin response. In study 2, CON further increased the glucose uptake via an increment in prehepatic insulin secretion that stimulated insulin sensitivity without changes in peripheral insulin and glucose concentrations. HEMI and PTX had 35% less glucose uptake in study 1, compared to CON, and increased glucose concentrations (+ 1.6 mmol L−1) in study 2. UVE had an intermediate defect. The causes of intolerance were different: HEMI had a defective first-phase insulin secretion (50% peripheral insulin concentrations) but maintained insulin sensitivity; PTX had normal peripheral insulin but only one-third of the insulin sensitivity of CON. Conclusions Hemipancreatectomy and systemic insulin delivery impair first-phase insulin secretion; second-phase peripheral insulinization (HEMI); insulin sensitivity (PTX); and a mechanism evidentiated in study 2 of CON that increases insulin sensitivity in response to prehepatic insulin secretion (both groups). Failure of these mechanisms is largely compensated by hyperglycaemia.
Published: 2000
Full Text: View/download PDF

26. Pexg (P : Cisplatin, E : Epirubicin, X : Capecitabine, G : Gemcitabine) versus PDXG (D : Docetaxel) regimen in advanced pancreatic cancer: A randomized phase II trial

Author: Reni, M (Reni, Michele)[ 1 ], Cereda, S (Cereda, Stefano)[ 1 ], Rognone, A (Rognone, Alessia)[ 1 ], Mazza, E (Mazza, Elena)[ 1 ], Passoni, P (Passoni, Paolo)[ 1 ], Nicoletti, R (Nicoletti, Roberto)[ 1 ], Arcidiacono P.G., Zerbi, A (Zerbi, Alessandro)[ 1 ], Balzano, G (Balzano, Gianpaolo)[ 1 ], Di Carlo, V (Di Carlo, Valerio)[ 1 ], Reni, M, (Reni, Michele)[, 1 ], Cereda, S, (Cereda, Stefano)[, 1 ], Rognone, A, (Rognone, Alessia)[, 1 ], Mazza, E, (Mazza, Elena)[, 1 ], Passoni, P, (Passoni, Paolo)[, 1 ], Nicoletti, R, (Nicoletti, Roberto)[, 1 ], Arcidiacono, P. G., Zerbi, A, (Zerbi, Alessandro)[, 1 ], Balzano, G, (Balzano, Gianpaolo)[, 1 ], Di, Carlo, V (Di, Carlo, and Valerio)[, 1 ]
Published: 2007

27. A prospective multicentre survey on the treatmentof acute pancreatitis in Italy

Author: R. Pezzilli a, G. Uomob, A. Gabbrielli c, A. Zerbi d, L. Frulloni e, P. De Rai f, L. Castoldi f, G. Cavallini e, V. Di Carlo d, BENASSAI, GIACOMO, R., Pezzilli a, ∗, G., Uomob, A., Gabbrielli c, A., Zerbi d, L., Frulloni e, P., De Rai f, L., Castoldi f, G., Cavallini e, V., Di Carlo d, and Benassai, Giacomo
Abstract: 30 citazioni su Scopus. L'articolo è il risultato di uno studio multicentrico di cui G. Benassai è un autore (membro Proinf-Aisp Study Group). RE: Missing Author Name Scopus nlinfo@elsevier.com; Dear Prof. Giacomo Benassai, Thank you very much for your detailed explanation. You have made the issue perfectly clear to me. Please be informed that I have escalated the issue to our Content Department for investigation and they will rectify the issue accordingly. As soon as I receive an answer, I am happy to contact you back. If I, or one of my colleagues, can assist you with another matter please do let us know. Kind Regards, Jeroen Hulsmann E-Helpdesk EMEA Coordinator Regional Sales Office - EMEA Elsevier B.V. [THREAD ID:1-1J7YLX6] -----Original Message----- From: gbenassa@unina.it Sent: 12/09/2012 14:52:37 To: nlinfo@elsevier.com Subject: Re: FW: Author's name correction Distinct Mr. Hulsmann Thank you for the sollicit interest about my query.This question it's very important for my career evaluation and also for the University 's department in which i belong. I have participated as a researcher in the 3 papers reported in my previous email,all of them were multicentric,so as of definition they involve diverse Institutions and Authors.In the list of Authors reported,members of the ProINF-AISP study group are citated under the voice "the members of the ProInf-AISP Study Group" who obviously do not correspond to a single unit.The single members of the citated group,amongst them the writer,are citated singularly on the last page's appendix ("G. Mosella, G. Benassai Policlinico Universitario Federico II") Napoli. The non citation of this partecipation of the Naples University Federico II comes with a problem regarding the financiation of the department,and also a discrimination on the evaluation of my personal profile as a researcher about the calculation of the citations in the H index. Furthermore in other circumstances i was citated as a participant in group studies of multicenter works,such as "Imipenem/cilastatina (1,5gr/die) versus meropenem (3,0gr/die) in pazienti con infezioni intra-addominali:risultati di uno studio clinico multicentrico,randomizzato,prospettico" publicated on Scandinavian Journal of Infectious Diseases 29:503-508,1997.I believe you have an original PDF file of this work and not a copy,therefore i result citated on scopus as a participant of the group study "Gruppo di studio Italiano" Thank you for your courtesy and interest,given the importance of the query. Trustfully yours, Prof. Giacomo Benassai Elsevier B.V. Registered Office: Radarweg 29, 1043 NX Amsterdam, The Netherlands, Registration No. 33156677 (The Netherlands) http://www.ncbi.nlm.nih.gov/pubmed/17602904 http://www.scopus.com/record/display.url?eid=2-s2.0-34547668852&origin=resultslist&sort=plf-f&src=s&st1=a+prospective+multicentre+survey+on+the+treatment+of+acute&sid=oNVoDQG_UHipYnJz9G131SP%3a630&sot=q&sdt=b&sl=78&s=TITLE-ABS-KEY-AUTH%28a+prospective+multicentre+survey+on+the+treatment+of+acute%29&relpos=9&relpos=9&searchTerm=TITLE-ABS-KEY-AUTH(a prospective multicentre survey on the treatment of acute) BACKGROUND: The Italian Association for the Study of the Pancreas released a diagnostic and therapeutic algorithm for acute pancreatitis in 1999. AIM: This study focused on the analysis of the therapeutic approach for the treatment of acute pancreatitis in Italy. PATIENTS: One thousand, one hundred and seventy-three patients were recruited: 1006 patients (85.8%) had mild acute pancreatitis (MAP) and 167 (14.2%) had the severe acute pancreatitis (SAP); 161 patients showed pancreatic necrosis at computed tomography; 121 patients (10.3%) had sequelae and 36 (3.1%) died. RESULTS: Non-steroidal anti-inflammatory drugs and tramadol were used more frequently in patients with the MAP whereas opioids and the association schedules were used more frequently in patients with the SAP (P
Published: 2007

28. EFFECTS OF CRYOPRESERVATION ON IN VITRO AND IN VIVO LONG-TERM FUNCTION OF HUMAN ISLETS1

Author: V. Di Carlo, Federico Bertuzzi, Biagio Eugenio Leone, Guido Pozza, Rita Nano, Carlo Socci, and Lorenzo Piemonti
Subjects: endocrine system, Transplantation, medicine.medical_specialty, geography, Glucose tolerance test, geography.geographical_feature_category, endocrine system diseases, medicine.diagnostic_test, Glucagon secretion, Biology, Islet, Glucagon, Cryopreservation, Endocrinology, Tolbutamide, In vivo, Internal medicine, medicine, medicine.drug
Abstract: Background. The possibility of performing transplantation several days after explant seems to be a peculiarity of islet grafts, and the opportunity to cryopreserve human islets may permit an indefinite period for modulating the recipient immune system. The aim of the present study was the evaluation of in vitro and in vivo functional properties of cryopreserved human islets. Methods. We used six consecutive human islet preparations not suitable for an immediate transplantation in diabetic patients because the limited islet mass separated. The in vitro function of cryo and fresh islets was studied by determination of insulin and glucagon secretion in response to such classical stimuli as glucose (16.7 mM), glucose (16.7 mM) + 3-isobutyl-1-methylxanthine (0.1 mM), arginine (10 mM), and tolbutamide (100 μM). In vivo islet function was assessed through intravenous glucose tolerance tests performed at 15, 30, 60, and 90 days after transplantation of 1000 hand-picked fresh or cryopreserved islets in nude mice. Results. Basal secretion of true insulin was significantly higher in cryopreserved islets than in fresh ones. The response of cryopreserved islets to arginine and glucose + isobutyl-1-methylxanthine seemed partially impaired. Proinsulin-like molecule secretion seemed higher in cryopreserved than in fresh islets in response to all secretagogues used, and the difference was statistically significant for arginine. The capacity of human cryopreserved islets to maintain a correct metabolic control in diabetic nude mice was progressively lost in 3 months. Conclusions. These findings showed that cryopreservation affects the function of isolated human islets, maintaining in vivo function for a limited period of time.
Published: 1999
Full Text: View/download PDF

29. Pylorus-preserving Pancreaticoduodenectomy versus Conventional Whipple Operation

Author: Alessandro Zerbi, V. Di Carlo, Gianpaolo Balzano, and V Corso
Subjects: medicine.medical_specialty, Pancreatic disease, medicine.medical_treatment, Adenocarcinoma, Gastroenterology, Pancreaticoduodenectomy, Internal medicine, medicine, Humans, Gastric emptying, business.industry, Stomach, digestive, oral, and skin physiology, medicine.disease, Pylorus, digestive system diseases, Surgery, Pancreatic Neoplasms, Treatment Outcome, medicine.anatomical_structure, Chemotherapy, Adjuvant, Pancreatectomy, Radiotherapy, Adjuvant, Pancreas, business, Abdominal surgery
Abstract: During 1990 to 1997 a series of 39 patients underwent a classic pancreaticoduodenectomy and 74 a pylorus-preserving pancreaticoduodenectomy for pancreatic adenocarcinoma. The two groups had similar tumor characteristics and received comparable adjuvant treatments. No significant differences were found between the two groups in terms of mortality, morbidity, gastric emptying, food intake resumption, and hospital stay. Postoperative survival was not affected by the preservation of the pylorus, determined by both univariate and multivariate analyses. Postoperative nutritional outcome was similar in the two groups, although patients receiving adjuvant chemotherapy had a better nutritional recovery if the whole stomach was preserved. In our opinion pylorus-preserving pancreatoduodenectomy is the treatment of choice of pancreatic head cancer.
Published: 1999
Full Text: View/download PDF

30. Splenectomy for idiopathic thrombocytopenic purpura

Author: W. Zuliani, A. Vignali, Luca Gianotti, E. Biguzzi, C. Bergamo, V. Di Carlo, A. Marassi, Marassi, A, Vignali, A, Zuliani, W, Biguzzi, E, Bergamo, C, Gianotti, L, Di Carlo, V, Vignali, Andrea, and Di Carlo, V.
Subjects: Adult, Male, Laparoscopic surgery, medicine.medical_specialty, medicine.medical_treatment, Splenectomy, Normal Distribution, Thrombotic thrombocytopenic purpura, Statistics, Nonparametric, Follow-Up Studie, immune system diseases, hemic and lymphatic diseases, Laparotomy, medicine, Humans, Laparoscopy, Aged, Purpura, Thrombocytopenic, Idiopathic, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Thrombocytopenic purpura, Surgery, Treatment Outcome, Hematologic disease, Female, business, Spleen, Human, Follow-Up Studies, Abdominal surgery
Abstract: This study aimed to compare the safety, efficacy, and clinical benefits of laparoscopic splenectomy (LS) to open splenectomy (OS) in patients with idiopathic thrombocytopenic purpura (ITP).The results from 14 consecutive patients who underwent LS for ITP were reviewed and compared with the results from patients who underwent OS for the same disease. Demographics, concomitant disease on admission, and platelet counts were evaluated, as were details of the surgical procedure, postoperative physiologic status, and hospital stay.Mean operative time was 88.3 min for OS and 146.4 min in LS group (p0.05). The conversion rate to open splenectomy was 7.1. Therapeutic response to splenectomy was 92.8% in the LS group and 86.6% in the OS group. Bowel canalization, return to liquid diet, and length of hospital stay were all significantly delayed in the OS group as compared with those who underwent LS (p = 0.01, p = 0.02, p = 0.005, respectively). In the OS group the morbidity rate was 13.3%, whereas in the LS group it was 7.1%.Laparoscopic splenectomy represents a valid alternative to conventional splenectomy in the treatment of ITP.
Published: 1999
Full Text: View/download PDF

31. Spontaneous hypoglycaemia after pancreas transplantation in Type 1 diabetes mellitus

Author: Giliola Calori, V. Di Carlo, A. Elli, Antonio Secchi, Doretta Bonfatti, Livio Luzi, Guido Pozza, Vincenzo Mazzaferro, Stefano Benedini, Alberto Battezzati, Rossana Caldara, Battezzati, A, Bonfatti, D, Benedini, S, Calori, G, Caldara, R, Mazzaferro, V, Elli, A, Secchi, Antonio, Di Carlo, V, Pozza, G, and Luzi, L.
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Hypoglycemia, Pancreas transplantation, Postoperative Complications, Endocrinology, Internal medicine, Internal Medicine, medicine, Humans, Insulin, Diabetic Nephropathies, Pancreatic hormone, Type 1 diabetes, C-Peptide, business.industry, medicine.disease, Kidney Transplantation, Liver Transplantation, Transplantation, Diabetes Mellitus, Type 1, Postprandial, medicine.anatomical_structure, Kidney Failure, Chronic, Female, Pancreas Transplantation, Pancreas, business
Abstract: Hypoglycaemia is an important complication of insulin treatment in Type 1 diabetes mellitus (DM). Pancreas transplantation couples glucose sensing and insulin secretion, attaining a distinctive advantage over insulin treatment. We tested whether successful transplantation can avoid hypoglycaemia in Type 1 DM. Combined kidney and pancreas transplanted Type 1 DM who complied with good function criteria (KP-Tx, n = 55), and isolated kidney or liver transplanted non-diabetic subjects on the same immunosuppressive regimen (CON-Tx, n = 14), underwent 1-day metabolic profiles in the first 3 years after transplantation, sampling plasma glucose (PC) and pancreatic hormones every 2 hours. KP-Tx had lower PG than CON-Tx in the night and in the morning and higher insulin concentrations throughout the day. KP-Tx had lower PC nadirs than CON-Tx (4.40 +/- 0.05 vs 4.96 +/- 0.16 mmol l(-1), ANOVA p = 0.001). Nine per cent of KP-Tx had hypoglycaemic values (PG less than or equal to 3.0 mmol l(-1)) in the profiles, both postprandial and postabsorptive, whereas none of CON-Tx did (p < 0.02). In conclusion, after pancreas transplantation, mild hypoglycaemia is frequent, although its clinical impact is limited. Compared to insulin treatment in Type 1 DM, pancreas transplantation improves but cannot eliminate hypoglycaemia. (C) 1998 John Wiley & Sons, Ltd.
Published: 1998
Full Text: View/download PDF

32. Mono-oligoclonal immunoglobulin abnormalities in diabetic patients after kidney transplantation: influence of simultaneous pancreas graft

Author: R. Castoldi, M. Bernardi, Antonio Secchi, V. Di Carlo, D. Giudici, Rossana Caldara, E. La Rocca, S. Furiani, Guido Pozza, Bernardi, M, LA ROCCA, E, Castoldi, R, DI CARLO, V, Caldara, R, Furiani, S, Giudici, D, Pozza, G, and Secchi, Antonio
Subjects: Adult, Graft Rejection, Male, Immunofixation, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Islets of Langerhans Transplantation, Pancreas transplantation, Gastroenterology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Kidney transplantation, Immunosuppression Therapy, Kidney, biology, business.industry, Antibodies, Monoclonal, Immunosuppression, Middle Aged, medicine.disease, Kidney Transplantation, Transplantation, medicine.anatomical_structure, Cytomegalovirus Infections, Immunology, Monoclonal, biology.protein, Female, Pancreas Transplantation, business
Abstract: Monoclonal components (MC) are detected in as high as 30 % of renal transplant recipients. Our aim was to evaluate the incidence, relevance and consequence of monoclonal components in patients with Type I (insulin-dependent) diabetes who received kidney (n = 22), kidney and whole pancreas (n = 41), kidney and segmental pancreas (n = 24) and kidney and islets (n = 12) transplants. Immunosuppression was based on prophylactic anti-lymphocyte globulins, corticosteroids, azathioprine and cyclosporin in all patients; acute rejection was treated with steroids or anti-lymphocyte monoclonal immunoglobulin therapy (OKT3) or both. Serum immunofixation was carried out in all patients before transplantation and then after at 6 months and then yearly. Monoclonal components were detected in 81 of 99 patients (82 %); 52 patients (52 %) developed them within 6 months of transplantation, 15 (15 %) between 6 and 12 months, with a peak prevalence at 1 year post-transplant (58 %) and a decrease thereafter (10 % at 9 years). Kidney recipients showed a lower incidence of monoclonal components when compared with those who received kidneys and segmental pancreases and those who received kidneys and whole pancreases. Monoclonal components were more often detected in patients who had previously experienced an acute renal rejection. Cytomegalovirus infection and acute rejection occurring in the same patient further increased the risk of developing monoclonal components, the development of which did not correlate with OKT3 treatment. A Post-transplant lymphoproliferative disorder was developed by two patients (2 %), one with 5 and the other with 6 monoclonal components. In conclusion, diabetic patients receiving kidney and/or Pancreas transplantation, experiencing both cytomegalovirus infection and acute rejection, are at greatest risk of developing monoclonal components but they appear to be benign and transient; multiple band detection is a marker for the subsequent development of post-transplant lymphoprolifertive disorder. [Diabetologia (1998) 41: 1176–1179]
Published: 1998
Full Text: View/download PDF

33. Pancreatic cancer resection in elderly patients

Author: Gianpaolo Balzano, Eugenio Villa, Alessandro Zerbi, and V. Di Carlo
Subjects: Adult, medicine.medical_specialty, Pancreatic disease, Adenocarcinoma, Weight Gain, Pancreaticoduodenectomy, Eating, Pancreatic cancer, Humans, Medicine, Grading (tumors), Aged, Aged, 80 and over, Geriatrics, Univariate analysis, business.industry, Middle Aged, medicine.disease, Survival Analysis, Surgery, Pancreatic Neoplasms, Treatment Outcome, medicine.anatomical_structure, Multivariate Analysis, Complication, business, Pancreas
Abstract: BackgroundPancreatic cancer resection is considered a high-risk procedure in patients aged 70 years or older.MethodsSome 398 patients with pancreatic adenocarcinoma, observed between 1990 and 1995, were reviewed. Operative outcome and survival of 33 patients aged 70 years or more were compared with findings in 85 younger patients who underwent resection.ResultsResectability was not significantly different between the elderly and younger patients; neither were mortality or overall morbidity. However, patients aged 70 years or more had more relaparotomies (P < 0·01) and more haemorrhagic complications (P < 0·001). Nutritional recovery after resection was satisfying even for elderly patients (body-weight gain and increase in serum albumin concentrations, P < 0·05). Univariate analysis showed a moderately poorer survival in the elderly (P = 0·09). Multivariate analysis demonstrated that tumour diameter, grading and Union Internacional Contra la Cancrum stage were independent prognostic factors, whereas age was not.ConclusionPatients aged 70 years or more can benefit from pancreatic cancer resection similarly to younger patients.
Published: 1998
Full Text: View/download PDF

34. Techniques of Pancreas Transplantation Through the World: An IPITA Center Survey

Author: Guido Pozza, Giuliana Ferrari, A. Baldi, B. Molteni, Renato Castoldi, Carlo Socci, M. Cristallo, V. Di Carlo, Antonio Secchi, Di Carlo, V, Castoldi, R, Cristallo, M, Ferrari, G, Socci, C, Baldi, A, Molteni, B, Secchi, Antonio, and Pozza, G.
Subjects: Transplantation, medicine.medical_specialty, business.industry, Data Collection, medicine.medical_treatment, General surgery, Professional practice, Pancreas transplantation, Exocrine secretion, Surveys and Questionnaires, medicine, Humans, Surgery, Center (algebra and category theory), Pancreas Transplantation, business
Published: 1998
Full Text: View/download PDF

35. Effects of Pancreas Transplantation on Quality of Life in Type I Diabetic Patients Undergoing Kidney Transplantation

Author: D Giudici, V. Di Carlo, Guido Pozza, S Martinenghi, R. Castoldi, Antonio Secchi, Secchi, Antonio, Martinenghi, S, Castoldi, R, Giudici, D, Di Carlo, V, and Pozza, G.
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Pancreas transplantation, Gastroenterology, Quality of life, Immunopathology, Internal medicine, medicine, Humans, Kidney transplantation, Uremia, Autoimmune disease, Transplantation, Kidney, business.industry, Patient Selection, Middle Aged, medicine.disease, Kidney Transplantation, Surgery, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Quality of Life, Female, Pancreas Transplantation, Pancreas, business
Published: 1998
Full Text: View/download PDF

36. Color Doppler imaging in the assessment of vascular involvement by pancreatic carcinoma

Author: Massimo Venturini, Sandro Sironi, Alessandro Zerbi, E. Angeli, M. Castrucci, Angelo Vanzulli, Marco Salvioni, A. Del Maschio, V. Di Carlo, Angeli, E, Venturini, M, Vanzulli, A, Sironi, S, Castrucci, M, Salvioni, M, Zerbi, A, Di Carlo, V, Del Maschio, A, and DEL MASCHIO, Alessandro
Subjects: Male, medicine.medical_specialty, Pancreatic disease, Sensitivity and Specificity, Predictive Value of Tests, medicine, Humans, Neoplasm Invasiveness, Radiology, Nuclear Medicine and imaging, Prospective Studies, Ultrasonography, Doppler, Color, Aged, business.industry, Vascular disease, General Medicine, Color doppler, Middle Aged, medicine.disease, Thrombosis, Vascular Neoplasms, Pancreatic Neoplasms, color doppler imaging, medicine.anatomical_structure, Adenocarcinoma, Female, Radiology, Complication, business, Pancreas, Blood vessel
Abstract: OBJECTIVE: The aim of our study was to assess the accuracy of color Doppler imaging in diagnosing the involvement of peripancreatic vessels by pancreatic carcinoma. SUBJECTS AND METHODS: We prospectively evaluated the color Doppler images of 61 patients with pancreatic carcinoma. Our evaluations occurred before surgery and focused on vascular involvement. Absence of contact or a short contiguity (< or = 2 cm) between tumors and peripancreatic vessels was considered to be a sign of resectability on color Doppler imaging; a long contiguity (> 2 cm), compression, encasement, or thrombosis was considered to be a sign of unresectability. In all patients, the sonographic diagnosis was compared with the surgical results. RESULTS: With color Doppler imaging, we detected signs of vascular involvement in 26 of 33 patients in whom vascular involvement was found at surgery. We detected no vascular involvement in 25 of 28 patients in whom no vascular involvement was found at surgery. No false-positive diagnoses occurred when vascular encasement was revealed by color Doppler imaging. For diagnosis of vascular involvement, the sensitivity, specificity, and overall accuracy of color Doppler imaging were 79%, 89%, and 84%, respectively; positive and negative predictive values were 89% and 79%, respectively. CONCLUSION: Color Doppler imaging is a sensitive and highly specific technique in assessing vascular involvement by pancreatic cancer when absence of contact or vascular encasement is seen. When vascular encasement is detected by color Doppler imaging, a definitive diagnosis of unresectability can be made, and further diagnostic procedures can be avoided. When sonography is used in the initial evaluation of pancreatic cancer, color Doppler imaging can improve the selection of patients for further diagnostic examinations or surgical exploration.
Published: 1997
Full Text: View/download PDF

37. Pancreas and Islet Transplantation: Current Progresses, Problems and Perspectives

Author: V. Di Carlo, Guido Pozza, Antonio Secchi, Secchi, Antonio, Dicarlo, V, and Pozza, G.
Subjects: medicine.medical_specialty, geography, geography.geographical_feature_category, business.industry, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Islets of Langerhans Transplantation, General Medicine, Islet, Bioinformatics, Kidney Transplantation, Biochemistry, Transplantation, Diabetes Mellitus, Type 1, Endocrinology, medicine.anatomical_structure, Transplantation Immunology, Internal medicine, Humans, Medicine, Pancreas Transplantation, Current (fluid), business, Pancreas
Published: 1997
Full Text: View/download PDF

38. Experimental gut-derived endotoxaemia and bacteraemia are reduced by systemic administration of monoclonal anti-LPS antibodies

Author: F. Almondo, Marco Braga, V. Di Carlo, R. Vaiani, Luca Gianotti, Gianotti, L, Braga, Marco, Vaiani, R, Almondo, F, Dicarlo, V., Braga, M, and Di Carlo, V
Subjects: medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Immunoglobulins, Bacteremia, Critical Care and Intensive Care Medicine, Monoclonal antibody, Sepsis, Mice, Endotoxin, Internal medicine, medicine, Animals, Mesenteric lymph nodes, Saline, Analysis of Variance, Mice, Inbred BALB C, biology, Animal, business.industry, Antibodies, Monoclonal, General Medicine, medicine.disease, Endotoxins, Endocrinology, medicine.anatomical_structure, Monoclonal, Immunology, Emergency Medicine, Systemic administration, biology.protein, Female, Surgery, Antibody, business
Abstract: This study aimed to investigate the effects and mechanisms of action of systemic administration of monoclonal antibodies, anti-endotoxin (HA-1A), in an animal model of gut-origin sepsis. In the first experiment, Balb/c mice were transfused with allogeneic blood (C3H/HeJ mice). Five days post-transfusion the animals were gavaged with 1 x 10(9) Escherichia coli and randomized into three groups (n = 22 each) to receive a sham burn (SB group) or a 20 per cent TBSA thermal injury, immediately followed by the systemic administration of monoclonal antibodies (3 mg/kg) (HA-1A group) or aliquots of sterile saline (Control group). The animal survival rate was observed for 10 days postburn. In the second experiment transfusion and burn injury were reproduced but the mice (n = 8/group) were gavaged with 10(9) E.coli labelled with 111indium oxine. Four hours after the burn the mesenteric lymph nodes, liver, lungs and blood were harvested to determine plasma endotoxin levels and the magnitude of translocation of labelled bacteria measured by the residual radioactivity in the organs. Circulating endotoxin levels were determined by limulus assay. The mortality rate of the HA-1A group (9 per cent) was similar to the SB group (0 per cent) and significantly lower than the control group (59 per cent) (P < 0.05). Both plasma endotoxin levels and degree of bacterial translocation in all extraintestinal tissues were significantly lower (by approximately 50 per cent) in the HA-1A group than in the control group (P < 0.05). Systemic administration of HA-1A exerts a beneficial effect by reducing the circulating levels of endotoxin and by increasing the gut barrier function to translocating microorganisms.
Published: 1996
Full Text: View/download PDF

39. Management of papillary microcarcinoma of the thyroid gland

Author: Elena Orsenigo, L. Invernizzi, P. Veronesi, P. Gini, Elena Beretta, Paolo Fiorina, Enrico Fiacco, Francesca Scaltrini, and V. Di Carlo
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Group ii, Risk Assessment, Actuarial Analysis, medicine, Humans, In patient, Thyroid Neoplasms, Thyroid cancer, Neoplasm Staging, Proportional Hazards Models, Retrospective Studies, Total thyroidectomy, business.industry, Thyroid, Neck dissection, General Medicine, Prognosis, medicine.disease, Carcinoma, Papillary, Surgery, Survival Rate, Dissection, Treatment Outcome, medicine.anatomical_structure, Oncology, Lymphatic Metastasis, Thyroidectomy, Papillary microcarcinoma, Lymph Node Excision, Female, Neoplasm Recurrence, Local, business, Neck, Follow-Up Studies
Abstract: Design To investigate the frequency, treatment and clinical behaviour of differentiated microcarcinoma of the thyroid gland (PTMC). Patients and methods Out of 376 patients submitted to surgical treatment for differentiated thyroid cancer from June 1980 to October 2003, 77 had been identified has having a PTMC (63 females, 14 males; mean age 43±13 years). Sixty-seven patients (87%) met the AMES risk definition for low (group I) and 10 (13%) for high-risk (group II) definition. The surgical procedures were lobo-isthmusectomy ( n =14) or subtotal thyroidectomy ( n =20) and total thyroidectomy ( n =43) with node dissection in 15 cases. Follow-up ranging from 9 to 274 months (mean 124±84). Results Overall patient survival rates were 100 and 94% at 20 years in groups I and II, respectively ( p =ns). There were no significant differences in surgical complications and in survival in patients submitted to total thyroidectomy when compared to partial thyroid resection. The presence of cervical node metastasis did not affect patient survival ( p =0.8). The overall mean survival time was 266 months. Conclusions Despite the overall excellent prognosis, PTMC was associated with a 1% disease-related mortality, a 2.5% local recurrence rate, 1% lymph-node recurrence rate, and 1% distant metastasis rate. We recommend total thyroidectomy accompanied by modified neck dissection if enlarged nodes are diagnosed.
Published: 2004
Full Text: View/download PDF

40. IN VIVO EVALUATION OF TIMING, DEGREE, AND DISTRIBUTION OF BACTERIAL TRANSLOCATION FOLLOWING EXPERIMENTAL SMALL BOWEL TRANSPLANTATION

Author: Marco Braga, F. Mangili, Luca Gianotti, V Baraldini, Carlo Socci, Massimo Locatelli, C. Bergamo, P Magnani, V. Di Carlo, Gianotti, L, Bergamo, C, Braga, Marco, Socci, C, Baraldini, V, Magnani, P, Mangili, F, Locatelli, M, Dicarlo, V., Braga, M, and Di Carlo, V
Subjects: Male, medicine.medical_specialty, Pathology, Time Factors, Time Factor, Isograft, Escherichia coli Infection, Chromosomal translocation, Biology, Gastroenterology, Permeability, Lactulose, Postoperative Complications, Indium Radioisotope, In vivo, Internal medicine, Intestine, Small, Escherichia coli, Organometallic Compounds, medicine, Animals, Mannitol, Lung, Escherichia coli Infections, Organometallic Compound, Transplantation, Intestinal permeability, Animal, Graft Survival, Indium Radioisotopes, Oxyquinoline, medicine.disease, Small intestine, Rats, Transplantation, Isogeneic, medicine.anatomical_structure, Liver, Rats, Inbred Lew, Rat, Postoperative Complication, medicine.drug
Abstract: These studies were designed to evaluate the correlation between morphologic and functional changes after heterotopic auxiliary small bowel isograft with systemic venous drainage and two ostomies in 20 Lewis rats. Morphologic damage of the graft was scored by full-thickness biopsies before surgery and 1, 3, 5, and 7 days after transplant. Functional evaluation of the graft was done, at the same time points, by urinary excretion of lactulose and mannitol injected in the proximal ostomy. The intestinal permeability was also studied by injecting Escherichia coli labeled with indium-111 oxine in the proximal ostomy. Translocation of radiolabeled bacteria was quantitated in extraintestinal tissues by radionuclide counts and number of viable organisms and in vivo by scintigraphic imaging. One day after transplant, significant graft damage (score 17.2 +/- 4.2) was observed when compared with the pretransplant value (7.3 +/- 2.6). The degree of tissue injury was similar on days 3 (15.8 +/- 3.5) and 5 (16.1 +/- 3.9) after transplant and remained high on day 7 (11.8 +/- 2.8). The lactulose to mannitol ratio showed a significantly increased permeability on day 1 (17.5) versus pretransplant values (2.6), remained high on day 3 (8.6), and returned to normal values on day 5 (2.8). Translocation of bacteria to distant organs, as measured by both radionuclide counts and number of viable organisms, was strikingly enhanced on day 1 after transplantation, compared with control animals, but returned to the pretransplant value on day 3. A good qualitative and quantitative correlation was observed between radionuclide counts in the extraintestinal organs and in vivo images obtained by scintigraphic scanning. In conclusion, in this model, timing and degree of bacterial translocation do not seem to correlate well, with the exception of the acute post-transplantation phase, with morphologic and permeability changes of the graft. Evaluation of translocation by scintigraphic imaging appears a suitable approach to study in vivo the kinetics and distribution of this process.
Published: 1995
Full Text: View/download PDF

41. Comparison between pylorus-preserving and Whipple pancreatoduodenectomy

Author: Giliola Calori, G. Balzano, Marco Braga, R. Patuzzo, V. Di Carlo, Alessandro Zerbi, Zerbi, A, Balzano, G, Patuzzo, R, Calori, G, Braga, Marco, Dicarlo, V., Braga, M, and Dicarlo, V
Subjects: Adult, Male, medicine.medical_specialty, Gastroenterology, Pancreaticoduodenectomy, Internal medicine, medicine, Humans, pancreaticoduodenenctomy, Pylorus, Serum Albumin, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Stomach, Body Weight, Operative mortality, Significant difference, Retrospective cohort study, Middle Aged, After discharge, medicine.disease, Survival Analysis, Surgery, Pancreatic Neoplasms, Treatment Outcome, Periampullary Adenocarcinoma, medicine.anatomical_structure, Multivariate Analysis, Adenocarcinoma, Female, business
Abstract: Between 1989 and 1993, 62 patients underwent Whipple pancreatoduodenectomy and 75 pylorus-preserving pancreatoduodenectomy (PPPD); 35 patients in the first group and 37 in the second had pancreatic adenocarcinoma while 17 and 21 patients respectively had periampullary adenocarcinoma. The aim of this retrospective study was the comparison of operative outcome, nutritional recovery and survival of patients who underwent these two operations. No significant differences were found between the two groups in operative mortality or morbidity, duration of gastric aspiration and time to start of solid meals. Patients who underwent PPPD had a better nutritional recovery: the increase of both body-weight and serum albumin level at 6 months after discharge was significantly higher for those who had preservation of the whole stomach (P < 0.001 and P < 0.05 respectively). No significant difference in survival was found between the two procedures when patients with pancreatic or periampullary adenocarcinoma were analysed separately.
Published: 1995
Full Text: View/download PDF

42. Benefits of Early Postoperative Enteral Feeding in Cancer Patients

Author: A. Vignali, Luca Gianotti, V. Di Carlo, A. Cestari, M. Profili, Marco Braga, Braga, M, Vignali, A, Gianotti, L, Cestari, A, Profili, M, and Di Carlo, V
Subjects: Male, medicine.medical_specialty, Randomization, Critical Care, Arginine, Gastroenterology, Enteral administration, Blood Urea Nitrogen, Enteral Nutrition, Postoperative Complications, Blood Protein, Stomach Neoplasm, Risk Factors, Stomach Neoplasms, Intensive care, Internal medicine, Fatty Acids, Omega-3, medicine, Humans, Surgical Wound Infection, Immunology and Allergy, Blood urea nitrogen, Aged, Food, Formulated, Postoperative Care, business.industry, Risk Factor, Pancreatic Neoplasm, Cancer, Blood Proteins, Hematology, Length of Stay, Middle Aged, medicine.disease, Surgery, Pancreatic Neoplasms, Regimen, Parenteral nutrition, Standard enteral formula, RNA, Female, Postoperative Complication, Energy Intake, business, Human
Abstract: Objective: To evaluate the effect of the early postoperative administration of an enriched enteral diet in cancer patients. Design: Randomised controlled study. Setting: Surgical intensive care unit of a university hospital. Patients: 77 consecutive patients undergoing curative surgery for gastric or pancreatic cancer. Interventions: Patients were randomised into 3 groups to receive: a standard enteral formula (n = 24); the same formula enriched with arginine, RNA, and omega-3 fatty acids (n = 26); isonitrogen isocaloric total parenteral nutrition (n = 27). Enteral nutrition was started within 12 h following surgery. Infusion rate was progressively increased reaching the full regimen on postoperative day (POD) 4. On admission and on POD 1 and 8, the following measurements were performed: serum level of total iron-binding capacity, albumin, prealbumin, retinol-binding protein (RBP), and cholinesterase. Delayed hypersensitivity response (DHR), IgG, IgM, IgA, lymphocyte subsets, and monocyte phagocytosis ability were also evaluated. Bioelectrical impedance analysis was performed preoperatively and on POD 2, 7, and 11. The rate and severity of postoperative infections and the length of hospital stay were evaluated. Results: In all patients, a significant drop of nutritional and immunologic parameters was observed on POD 1. A significant increase of prealbumin (p < 0.02), RBP (p < 0.005), monocyte phagocytosis ability (p < 0.001), and DHR (p < 0.005) was found on POD 8 only in the group fed with the enriched diet. A significant reduction of severity of postoperative infections and length of postoperative stay was found in the group with the enriched diet compared to the other groups. Conclusions: These data are suggestive of an improvement of the nutritional and immunologic status and clinical outcome in cancer patients who receive an enriched enteral diet in the early postoperative course.
Published: 1995
Full Text: View/download PDF

43. Cardiovascular outcomes after kidney-pancreas and kidney alone transplantation

Author: E. LA ROCCA, P. FIORINA, C. ROSSETTI, G. LUSIGNANI, F. FAZIO, D. GIUDICI, R. CASTOLDI, G. BIANCHI, V. DI CARLO, G. POZZA, SECCHI , ANTONIO, E., LA ROCCA, P., Fiorina, C., Rossetti, G., Lusignani, F., Fazio, D., Giudici, R., Castoldi, G., Bianchi, V., DI CARLO, G., Pozza, and Secchi, Antonio
Published: 2001

44. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author: H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. D'Angelo, N. Baumann, S. Yorifuji, H. P. Endtz, M. A. Cassatella, R. A. C. Hughes, V. Golzi, A. Bittencourt, A. Ferreira, M. Sanson, C. Alper, M. Vermeulen, M. A. A. van Walderveen, E. Alexiou, C. H. Lucas, M. Fiorelli, Y. N. Debbink, R. Gil, S. Congia, T. Banerjee, J. M. Bouchard, A. N. Pinto, A. Ceballos-Baumann, G. Grollier, P. I. M. Schmitz, M. D. Catata, N. Lahat, N. S. Rao, P. Papathanasopoulos, J. Valls-Solé, D. Claus, G. Schroter, A. Castro, C. Videbaek, R. Martinez Dreke, A. D. Platts, M. Hermesl, A. C. PeÇanha-Martins, M. Cardoso Silva, P. Masnou, M. J. A. Tanner, Ch. Confavreux, B. Mishu, H. Rasmussen, L. Valenciano, Carlo Pozzilli, S. W. Li, V. Salzman, Y. Vashtang, Massimo Franceschi, M. Severo, G. Deuschl, S. Setien, G. Mariani, A. Protti, J. Castillo, M. J. B. Taphoorn, M. Frontali, I. Milonas, D. Decoq, J. A. Navarro, S. Castellvi-Pel, C. Ertikin, M. Urtasun, Y. Lajat, B. E. Kendall, E. Verdu, B. Gueguen, E. Boisen, R. Couderc, A Danek, JM Stevens, F. Nicoli, L. Feltri, M. L. Vazquez-Andre, J. A. Morgan-Hughes, L. D'Angelo, F. Y. Liew, L. F. Pascual, J. Patrignani Ochoa, Vittorio Martinelli, J. Cophignon, L. Zhang, S. Martin, J. F. Meder, H. C. Buschmann, L. Bertin, J. van Gijn, A. Barreiro, A. Cools, C. Leon, A. Berod, E. A. Anllo, E. Zanette, L. Petrov, R. Barona, B. Gallicchio, P. J. Cozzone, N. Diederich, G. Cancel, L. Schelosky, P. Orizaola, K. Yulug, S. Ozer, Valeria A. Sansone, B. Guiraud-Chaumeil, K. Voigt, P. Labauge, M. Eoli, J. Zhu, J. Aguirre, M. Ferrarini, B. Zyluk, E. Planas, A. Cadilha, C. Tortorella, H. Bismuth, C. E. Counsell, A. Laun, A. Ferlini, Rio J. Montalban, N. Biary, L. Becker, M. Fardeau, M. Poloni, V. M. S. de Bruin, C. Fornada, J. Barros, E. Ganzmann, E. Touze, D. Wallach, J. Peila, H. Fujimura, M. T. Iba-Zizen, G. Macchi, C. Villoslada, R. Gouider, Ph. Rondepierre, P. Grummich, P. Chiodi, C. Conte, M. Michels, P. Annunziata, G. Semana, C. Sommer, J. Vajsar, D. Zekin, J. Kulisevsky, David G. Munoz, B. Jacotot, M. Magoni, A. Luxen, T. Garcia-Silva, S. Di Cesare, Christophe Tzourio, M. Gomori, I. Picomell, L. Santoro, F. Villa, Giovanni Pennisi, T. Ribalta, J. M. Molto, L. Marzorati, P. Loiseau, F. Gemignani, A. Gironell, J. Wissel, A. Prusinski, F. Cailloux, P. Villanueva-Hemandez, P. Cozzone, T. Del Ser, J. Sans-Sabrafen, M. Zappia, P. W. A. Willems, G. Tchernia, D. Gardeur, R. Bauer, F. Palomo, H. Metz, S. Lamoureux, C. Chastang, I. Reinhard, A. Goldfarb, S. Harder, Jordi Río, C. Ozkara, E. Tekinsoy, P. Vontobell, J. De Recondo, M. Rabasa, L. Lacomblez, F. Boon, Dgt Thomas, V. Palma, Renato Mantegazza, A. Dervis, M. Nueckel, B. YalÇinerner, I. Duran, G. Dalla Volta, A. Zubimendi, J. Pinheiro, A. Marbini, Xavier Montalban, H. Wekerle, X. Pereira Monteino, F. Crespo, F. Koskas, N. Battistini, C. Ruiz, H. Offner, J. de Pommery, P. Kanovsky, J. Y. Barnett, J. Pardo, G. Tomei, R. Rene, H. M. Lokhorst, P. Thajeb, H. Bilgin, D. McGehee, R. Fahsold, L. Morgante, Katie Sidle, C. Delwaide, M. N. Diaye, P. H. Rice, A. Creange, C. Sabev, K. Stephan, K. WeilBenborn, G. Magnani, L. Grymonprez, F. Cardellach, M. Kaps, N. G. Meco, F. Vega, V. Bonifati, A. Desomer, M. Baldy-Moulinier, G. Kvale, F. J. Authier, B. Yegen, T. Ho, J. M. Rozet, E. A. Cabanis, L. Bruce, L. Ambrosoli, M. A. Petrella, M. Hernandez, P. Timmings, H. B. van der Worp, F. Mahieux, A. Urbano-Marquez, D. A. Krendel, A. A. Garcia, R. Divari, R. Michalowicz, M. R. Piedmonte, M. Bondavalli, M. Zanca, P. F. Ippel, Onofre Combarros, B. Tavitian, E. Hirsch, I. Anastasopoulos, A. Roses, A. Köhler, P. Vienna, V. Timmerman, P. Sergi, F. Cornelio, A. Di Pasquale, R. Verleger, S. Castellvirel, J. Proano, B. van Moll, F. Rubio, W. Hacke, I. Lavenu, L. Zetta, M. W. Tas, N. Bittmann, M. Bonamini, O. R. Hommes, V. Dousset, N. Afsar, S. Belal, R. R. Myers, J. Goes, Giuseppe Vita, E. Clementi, V. G. Karepov, M. Jueptner, A Vincent, P. Emmrich, Th. Heb, A. Caballo, J. Gallego, T. Mokrusch, C. Perla, L. Gebuhrer, O. Titlbach, Alessandro Prelle, A. Czlonkowska, M. Russo, D. Hadjiev, T. S. Chkhikvishvili, M. Oehlschlager, G. Becker, I. Günther, E. N. Stenager, J. Garcia Agundez, J. Casademont, J. Batlle, S. Podobnik-Sarkanji, C. Alonso-Villaverde, B. Delaguillaume, B. Genc, B. Mazoyer, A. Rodriguez-Al-barino, Ch. Hilger, B. Ferrero, R. Price, W. Grisold, L. Fuhry, D. Oulbani, D. Ewing, A. Petkov, W. Walther, A. Gokyigit, John Newsom-Davis, J. Tayot, D. Seliak, G. Pelliccioni, D. Campagne, K. Kessler, F. Boureau, D. Perani, J. P. N'Guyen, N. Tchalucova, B. A. Antin-Ozerkis, C. Lacroix, B. D. Aronovich, I. H. Jenkins, E. A. dos Reis, M. Hortells, H. M. Meinck, H. Ch. Buschmann, S. C. J. M. Jacobs, T. Wetter, P. Creissard, N. Martinez, J. Weidenfeldl, H. J. Sturenburg, G. Damlacik, V. Gracia, J. C. Turpin, A. Pou-Serradell, J. P. Vincent, T. Gagoshidze, U. Ozkutlu, M. McLeod, K. Siegfried, I. Tchaoussoglou, J. Hildebrand, S. Kowalska, M. C. Picot, G. Galardin, L. Crevits, F. Andreetta, S. Larumbe-Lobalde, G. de la Sierra, J. C. Alvarez-Cermeno, R. J. Seitz, P. L. Oey, L. Ptacek, A. M. J. Paans, A. Wirrwar, A. Schmied, J. Uilchez, H. Tounsi, D. Hipola, V. Avoledo, Y. Hirata, P. Vermersch, T. M. Aisonobe, J. Valls-SoIè, H. Staunton, J. Dichgans, R. Karabudak, I. Dones, G. Porta, E. Janssens, Maria Martinez, J. M. Fernandez-Real, R. Villagra, Y. Yoshino, C. Kabus, K. Schimrigk, I. Girard-Buttaz, F. Piccoli, F. Aichner, P. Zuchegna, S. M. Al Deeb, F. Bono, N. Busquets, A. Jobert, Patrizia Ciscato, M. Martin, L. Polman, S. Darbra, V. Le Cam-Duchez, F. Baldissera, B. Baykan-Kurt, D. Guez, M. Bratoeva, H. Matsui, M. Mila, H. Perron, L. Bjorge, G. Husby, Steven T. DeKosky, D. R. Cornblath, J. M. Gabriel, J. J. Poza, Y. Wu, A. Toscano, R. P. Kleyweg, J. Kuhnen, S. O. Confort-Gouny, A. Barcelo, A. M. Conti, C. Fiol, C. Steichen-Wiehn, J. Rodes, M. Cavenaile, C. Vedeler, M. Drlicek, C. Argentino, M. L. Peris, A. Cervello, A. Z. GinaÏ, S. Yancheva, D. Passingham, S. Aoba, D. L. Lopez, T. Rechlin, K. Sonka, L. Grazzi, V. Folnegovic-Smalc, Maurizio Moggio, S. Rivaud, F. G. I. Jennekens, C. H. Hartard, H. Meierkord, G. Stocklin, M. D. Catala, W. C. McKay, E. Salmon, C. Navarro, I. Pastor, L. Canafoglia, M. De Braekeleer, P. K. Thomas, C. Mocellini, C. Pierre-Jerome, M. C. Dalakas, P. Pollak, M. Levivier, Niall Quinn, G. E. Rivolta, Z. Tunca, H. Zeumer, J. Garcia Tena, St. Guily, P. Gaudray, Johannes Kornhuber, V. Petrunjashev, R. Montesanti, R. J. Abbott, H. Petit, G. Kiteva-Trencevska, F. Carletto, C. Ramo, I. M. Pino, P. Beau, G. F. Mennuni, F. Moschian, F. Meneghini, B. Zdziarska, B. Fontaine, C. Stephens, G. Meco, K. Reiners, G. Badlan, M. Sessa, I. Degaey, S. M. Hassan, C. Albani, F. Caroeller, M. Schroeder, G. Savettieri, A. Novelletto, R. Kurita, P. Oschmann, I. Plaza, M. Oliveres, Simone Spuler, A. Molins, M. Schwab, J. R. Kalden, C. P. Gennaula, Y. Baklan, O. Picard, J. M. Léger, B. Mokri, E. Ghidoni, M. Jacob, D. Deplanque, W. JÄnisch, C. De Andres, P. De Deyn, G. Guomundsson, B. Herron, J. Barado, J. L. Gastaut, Guglielmo Scarlato, F. Poron, Nicola Jones, H. Teisserenc, C. P. Hawkins, A. J. Steck, H. C. Chandler, S. Blanc, J. H. Faiss, Jm. Soler Insa, I. Sarova-Ponchas, M. Malberin, A. Sackmann, G. De Vuono, K. Kaiser-Rub, K. Badhia, E. Szwabowska-Orzeszko, S. Ramm, C. Jodice, G. Franck, J. Marta-Moreno, R. Sciolla, C. Fritz, A. Attaccalite, F. Weber, E. Neuman, M. Cannata, A. Rodriguez, I. Nachainkin, R. Raffaele, T. S. Yu, N. Losseff, E. Fabrizio, C. Khati, M. Keipes, M. P. Ortega, M. Ramos-Alvarez, E. Brambilla, A. Tarasov, K. H. Wollinsky, O. B. Paulson, F. Boller, G. Bozzato, H. Wagnur, R. Canton, D. Testa, E. Kutluaye, M. Calopa, D. Smadja, G. Malatesta, F. Baggi, A. Stracciari, G. Daral, G. Avanzini, J. Perret, J. Arenas, P. Boon, I. Gomes, A. Vortmeyer, P. Cesaro, S. Venz, E. Bernd Ringelstein, N. Milani, D. Laplane, P. Seibel, E. Tournier-Lasserve, Alexis Brice, L. Motti, E. Wascher, R. J. Abbot, F. Miralles, A. Turon, P. De Camilli, G. Luz, G. C. Guazzi, S. Tekin, F. Lesoin, T. Kryst, N. Lannoy, F. Gerstenbrand, S. Ballivet, H. A. M. van Diemen, J. Lopez-ArLandis, P. Bell, A. Silvani, M. A. Garcia, S. Vorstrup, D. Langdon, S. Ueno, B. Sander, V. Ozurk, C. Gurses, P. Berlit, J. M. Martinez-Lage, M. Treacy, S. O. Rodiek, S. Cherninkova, J. Grimaud, P. Marozzi, K. Hasert, S. Goldman, S. H. Ingwersen, A. Taghavy, T. Roig, R. Harper, I. Sarova-Pinchas, Anthony H.V. Schapira, R. Lebtahi, A. Vidaller, B. Stankov, D. Link, J. p. Malin, V. Petrova, Ludwig Kappos, J. L. Ochoa, T. Torbergsen, M. Carpo, M. Donato, Simon Shorvon, J. Mieszkowski, J. Perez-Serra, Raymond Voltz, G. Comi, S. Rafique, A. Perez-Sempere, N. Khalfallah, S. Bailleul, M. Borgers, S. Banfi, S. Mossman, A. Laihinen, G. Filippini, R. A. Grunewald, E. Stern, H. D. Herrmann, A. G. Droogan, P. Xue, A. Grilo, L. La Mantia, J. H. J. Wokke, S. Pizzul, Kie Kian Ang, S. Rapaport, W. Szaplyko, B. Romero, P. Brunet, A. Albanese, C. Davie, V. Crespi, F. Birklein, H. Sharif, L. Jose, D. Auer, N. Heye, Martin N. Rossor, C. E. Henderson, M. J. Koepp, J. Rubio, P. L. Baron, S. Mahal, Juha O. Rinne, J. I. Emparanza, S. E. C. Davies, Frederik Barkhof, M. Riva, R. E. Brenner, B. A. Pope, Lemaire, E. Dupont, D. Ulbricht, G. C. Pastorino, R. Retska, E. Chroni, A. Danielli, V. Malashkhia, T. Canet, J. C. Garcia-Valdecasas, J. Serena, R. A. Pfeiffer, B. Wirk, B. Muzzetto, V. Caruso, M. L. Giros, A. Ming Wang, E. L. E. Guern, F. Bille-Turg, Y. Satoh, C. H. Franke, M. Ait-Kaci-Ahmed, D. Genis, T. Pasierski, D. Riva, M. Panisset, A. Chamorro, P.A. van Doorn, S. Schellong, H. Hamer, F. Durif, P. Krauseneck, Y. Bahou, B. A. Pickut, M. Rijnites, H. Nyland, G. Jager, L. L. Serra, A. Rohl, X. P. Li, O. Arena, Hubert Kwieciński, N. Milpied, M. C. Bourdel, S. Assami, L. Law, J. Moszkowski, J. W. Thorpe, M. Aguennouz, R. Martin, D. Hoffmann, P. Morris, A. Destée, D. J. Charron, U. Senin, A. P. SempereE, M. Dreyfus, A. L. Benabid, M. Gomez, S. Heindle, M. C. Morel-Kopp, M. Hennerici, A. I. Santos, M. Djannelidze, N. Artemis, John Collinge, T. Rundek, M. Y. Voloshin, P. de Castro, Th. Wiethege, D. A. S. Compston, D. Schiffer, A. J. Hughes, D. Jimenez, V. Parlato, A. Papadimitriou, J. M. Gergaud, R. Sterzi, J. Arpa, G. de Pinieux, F. Buggle, P. Gimbergues, H. Ruottinen, R. Marzella, W. Koehler, Y. Yurekli, A. Haase, Z. Privorkin, G. K. Harvey, B. Chave, A. J. Grau, E. M. Stadlan, J. List, C. Zorzi, B.W. van Oosten, P. Derkinderen, B. Casati, J. M. Maloteaux, K. Vahedi, W. L. J. van Putten, J. C. Sabourin, D. Lorenzetti, Plenevaux, J. W. B. Moll, A. Morento Fernandez, M. Lema, M. A. Horsfleld, P. De Jongh, S. Gikova, K. Kutluk, Monique M.B. Breteler, P. Saddier, A. Berbinschi, R. E. Cull, P. Echaniz, H. Kober, C. Minault, V. Kramer, A. L. Edal, S. Passero, T. Eckardt, K. E. Davies, A. Salmaggi, R. Kaiser, A. A. Grasso, Claudio Mariani, G. Egersbach, Hakan Gurvit, O. Dereeper, C. Vital, L. Wrabetz, A. Vecino, M. Aguilar, G. Bielicki, H. Becher, J. Castro, S. Iotti, M. G. Natali-Sora, E. Berta, S. Carlomagno, L. Ayuso-Peralta, P. H. Rondepierre, I. Bonaventura, B. V. Deuren, N. Van Blercom, M. Sciaky, J. Faber, M. Alberoni, M. Nieto, F. Sellal, C. Stelmasiak, M. Takao, J. Bradley, D. Zegers de Beyl, H. Porsche, G. Goi, H. Pongratz, F. Chapon, S. Happe, Robin S. Howard, B. Weder, S. Vlaski-Jekic, J. M. Ferro, R. Nemni, A. Daif, Herbert Budka, W. Van Paesschen, B. Waldecker, F. Carceller, J. Lacau, F. Soga, J. Peres Serra, E. Timmerman, A. M. vd Vliet, J. L. Emparanza, N. Vanacore, A. Pizzuti, N. Marti, A. Davalos, N. Ayraud, U. Zettl, J. Vivancos, Z. Katsarou, H. M. Mehdorn, G. Geraud, M. Merlini, M. Schröter, A. Ebner, M. Lanteri-Minet, R. Soler, G. P. Anzola, S. L. Hauser, L. Cahalon, S. DiDonato, R. Cantello, M. Marchau, J. Gioanni, F. Heidenreich, J. Manuel Martinez Lage, P. Descoins, F. Woimant, J. F. Campo, M. H. Verdier-taillefer, M. S. F. Barkhof, G. J. Kemp, A. O. Ceballos-Baumann, J. Berciano, M. Guidi, Tarek A. Yousry, B. Chandra, A. Rapoport, P. Canhao, A. Spitzer, T. Maeda, J. M. Pereira Monteiro, V. Paquis, Th. Mokrusch, F. J. Arrieta, I. Sangla, F. Canizares-Liebana, Lang Chr, André Delacourte, V. Fetoni, P. Kovachev, D. Kidd, L. Ferini-Strambi, E. Donati, E. Idman, A. Chio, C. Queiros, D. Michaelis, S. Boyacigil, A. Rodrigo, S. M. Yelamos, B. Chassande, P. Louwen, C. Tranchant, E. Ciafalon, A. Lombardo, A. Twijnstra, A. L. Fernandez, H. Kott, A. Cannas, N. Zsurger, T. Zileli, E. Metin, P. C. Bain, G. Fromont, B. Tedesi, A. Liberani, X. Navarro, M. C. Rowbotham, V. Hachinski, F. Cavalcanti, W. Rostene, R. M. Gardiner, F. Gonzalez, B. Köster, E. A. van der Veen, J. P. Lefaucheur, C. Marescaux, D. Boucquey, E. Parati, S. Yamaguchi, A. S. Orb, R. Grant, G. D. P. Smith, P. Goethals, M. Haguenau, G. Georgiev, I. N. van Schaik, Guy A. Rouleau, E. Iceman, G. Fayet, M. G. Kaplitt, C. Baracchini, H. Magnusson, G. Meneghetti, N. Malichard, M. L. Subira, D. Mancia, A. Berenguer, D. Navarrete Palau, H. Franssen, G. Kiziltan, M. P. Lopez, J. Montalt, S. Norby, R. Piedra Crespo, T. L. Rothstein, R. Falip, B. YalÇiner, F. Chedru, I. W. Thorpe, F. W. Heatley, D. S. C. Ochoa, C. Labaune, M. Devoti, O. Lider, Jakob Korf, N. Suzuki, E. A. Maguire, A. Moulignier, J. C. van Swieten, F. Monaco, J. Cartron, A. Steck, B. Uludag, M. Alexandra, H. Reichmann, T. Rossi, L. E. Claveria, A. M. Crouzel, M. A. Mena, J. Gasnault, J. W. Kowalski, S. I. Mellgren, V. Feigin, L. Demisch, J. Montalban, J. Renato, J. Mathieu, N. Goebels, L. Bava, K. Kunre, M. Pulik, S. Di Donato, C. Tzekov, H. Veldman, S. Giménez-Roldan, B. Lechevalier, L. Redondo, B. Pillon, M. Gugenheim, E. Roullet, J. M. Valdueza, C. Gori, H. J. Friedrich, L. de Saint Martin, F. Block, E. Basart, M. Heilmann, B. Becq Giraudon, C. Rodolico, G. Stevanin, Elizabeth K. Warrington, A. T. M. Willemsen, K. Kunze, C. Ben Hamida, M. Alam, J. R. ùther, A. Battistel, G. Della Marca, Richard S. J. Frackowiak, F. Palau, T. Brandt, Chicoutimi, L. Bove, L. Callea, A. Jaspert, T. Klopstock, K. Fassbender, Alan J. Thomas, A. Ferbert, V. Nunes, Douglas Russell, P. Garancini, C. Sanz-Sebastian, O. Santiag, G. Dhaenens, G. Seidel, I. Savic, A. Florea-Strat, M. Rousseaux, N. Catala, E. O'Sullivan, M. J. Manifacier, H. Kurtel, T. Mendel, P. Chariot, M. Salas, D. Brenton, R. Lopez, J. Thorpe, Jimmy D. Bell, E. Hofmann, E. Botia, J. Pacquereau, A. Struppler, C. d'Aniello, D. Conway, A. Garcia-Merino, K. Toyooka, S. Hodgkinson, E. Ciusani, Stefano Bastianello, A. Andrade Filho, M. Zaffaroni, G. Pleiffer, F. Coria, A. Schwartz, D. Baltadjiev, I. Rother, K. Joussen, J. Touchon, K. Kutlul, P. Praamstra, H. Sirin, S. Richard, C. Mariottu, L. Frattola, S. T. Dekesky, G. Wieneke, M. Chatel, O. Godefroy, C. Desnuelle, S. OzckmekÇi, C. H. Zielinski, P. van Deventer, S. Jozwiak, I. Galan, J. M. Grau, V. Vieira, T. A. Treves, S. Ertan, A. Pujol, S. Blecic, E. M. Zanette, F. Ceriani, W. Camu, L. Aquilone, A. Benomar, F. Greco, A. Pascual-Leone Pascual, T. Yanagihara, F. A. Delfino, R. Damels, S. Merkelbach, J. Beltran, A. Barrientos, S. Brugge, B. Hildebrandt-Müller, M. H. Nascimento, M. Rocchi, F. Cervantes, E. Castelli, R. M. Pressler, S. Yeil, A. del Olmo, J. L. Herranz, L. J. Kappelle, Y. Demir, N. Inoue, R. Hershkoviz, A. Luengo, S. Bien, F. Viallet, P. Malaspina, G. De Michele, G. Nolfe, P. Adeleine, T. Liehr, G. Fenelon, H. Masson, Kailash P. Bhatia, W. Haberbosch, S. Mederer, R. S. J. Frackowiak, Tanya Stojkovic, S. Previtali, A. E. Harding, W. Kohler, N. P. Quin, T. R. Marra, J. P. Moisan, A. Melchor, M. L. Viguera, Mary G. Sweeney, G. L. Romani, J. Hezel, R. A. Dierckx, R. Torta, A. Kratzer, T. Pauwels, D. Decoo, Adriana Campi, Neil Kitchen, J. Haas, U. Neubauer, J. J. Merland, A. Yagiz, A. Antonuzzo, A. Zangaladze, J. Parra, Pablo Martinez-Lage, D. J. Brooks, S. Hauser, R. Di Pierri, M. Campero, R. Caldarelli-Stefano, A. M. Colangelo, J. L. Pozo, C. Estol, F. Picard, A. Palmieri, J. Massons, JT Phillips, G. B. Groozman, R. Pentore, L. M. Ossege, C. Bayon, Hans-Peter Hartung, R. Konyalioglu, R. Lampis, D. Ancri, M. Miletta, F. J. Claramonte, W. Retz, F. Hentges, JM Cooper, M. Cordes, M. Limburg, M. Brock, G. R. Coulton, K. Helmke, Rosa Larumbe, A. Ohly, F. Landgraf, A. M. Drewes, Claudia Trenkwalder, M. Keidel, T. Segura, C. Scholz, J. HÄgele, D. Baudoin-Martin, P. Manganelli, J. Valdueza, M. Farinotti, U. Zwiener, M. P. Schiavalla, Y. P. Young, O. Barlas, G. Hertel, E. H. Weiss, M. Eiselt, A. Lossos, M. Bartoli, L. Krolicki, W. Villafana, W. Peterson, Nicoletta Meucci, C. Agbo, R. Luksch, F. Fiacco, G. Ponsot, M. Lopez, Howard L. Weiner, M. D. Alonso, K. Petry, Sanjay M. Sisodiya, P. Giustini, S. Tyrdal, R. Poupon, J. Blanke, P. Oubary, A. A. Kruize, H. Trabucchi, R. R. C. Stewart, H. Grehl, B. M. Kulig, V. Vinhas, D. Spagnoli, B. Mahe, J. Tatay, C. Hess, M. D. Albadalejo, G. Birbamer, M. Alonso, F. Valldeoriola, J. Figols, I. Wirguin, E. Diez Tejedor, C. S. Weiller, L.H. van den Berg, P. Barreiro, L. Pianese, S. Cocozza, R. Kohnen, E. Redolfi, F. Faralli, G. Gosztonyl, A. J. Gur, A. Keyser, V. Fichter-Gagnepain, B. Wildemann, E. Omodeo-Zorini, Gregoire, J. Schopohl, F. Fraschini, G. Wunderlich, B. Jakubowska, F. P. Serra, N. B. Jensen, O. Delattre, C. Leno, A. Dario, P. Grafe, F. Graus, M. C. Vigliani, J. L. Dobato, Philip N. Hawkins, R. Marés, A. Rimola, N. Meussi, G. Aimard, W. Hospers, A. M. Robertson, C. Kaplan, W. Lamadé, Karen E. Morrison, Amadio, E. Kieffer, F. Dromer, P. Bernasconi, M. Repeto, Davide Pareyson, Jeremy Rees, A. Guarneri, P. Odin, P. Bouche, L. Nogueira, J. Munoz, L. Leocani, M. J. Arcusa, R. S. J. Frackowiack, John S. Duncan, D. Karacostas, D. Edwin, I. Costa, M. Menetrey, P. Grieb, A. M. Salvan, S. Cunha, P. Merel, P. Pfeiffer, A. Astier, F. Federico, A. Mrabet, M. G. Buzzi, L. Knudsen, I. F. Pye, L. Falqui, C. R. Hornig, C. E. Shaw, C. Brigel, T. C. Britton, R. Codoceo, T. Pampols, Vincent J. Cunningham, N. Archidiacono, G. Chazot, J. B. Posner, L. L. O. Befalo, M. Monclus, C. Cabezas, H. Moser, H. Stodal, J. Ley-Pozo, L. Brusa, R. Di Mascio, P. Giannini, J. Fernandez, R. Santiago Luis, J. Garcia Tigera, J. Wilmink, P. Pignatelli, M. El Amrani, V. Lucivero, M. Baiget, R. Lodi, P. H. Cabre, L. Grande, A. Korczyn, R. Fahlbusch, C. Milanese, W. Huber, J. Susseve, H. C. Nahser, K. Mondrup, X. O. Breakefield, J. Sarria, T. H. Vogt, A. Alessandri, M. Daffertshofer, I. Nelson, M. L. Monticelli, O. Dammann, G. G. Farnarier, G. Felisari, A. Quattrini, A. Boiardi, P. Mazetti, H. Liu, J. Duarte, M. E. Gaunt, H. Strik, N. Yulug, A. Urman, J. Posner, Aida Suarez Gonzalez, Ma. L. Giros, Z. Matkovic, D. Kompf, A. D. Korczyn, A. Steinbrecher, R. Wenzel, M. C. de Rijk, R. Doronzo, J. Julien, O. Hasegawa, M. Kramer, V. Collado-Scidel, M. Alonso de Lecinana, L. Dell'Arciprete, S. Rapuzzi, S. Bahar, H. Willison, M. T. Ramacci, J.J. Martin, Lopez-Bresnahan, C. Malapani, R. Haaxma, T. Rosenberg, J. Patrignani, R. Vichi, Martin R. Farlow, J. Roquer, L. Krols, M. Pimenta, C. Bucka, U. Klose, M. Roberts, J. Salas-Puig, R. Ghnassia, A. Mercuri, C. Maltempo, I. Tournev, P. Homeyer, D. Caparros-Lefevre, E. P. O. Sullivan, T. Vashadze, Ph. Lyrer, A. Deltoro, H. Kondo, M. Steinling, A. Graham, G. C. Miescher, A. Pace, D. Branca, G. Avello, H. H. Kornhuber, D. Fernandes, H. Friedrich, R. Chorao, H. O. Lüders, R. T. Bax, J. A. Macias, N. Yilmaz, J. Veroust, M. Miller, S. Confort-Gouny, J. L. Sastre, D. Servello, G. Boysen, S. Koeppen, V. Planté-Bordeneuve, H. Albrecht, R. H. M. King, G. Orkodashili, R. Doornbos, H. Toyooka, V. Larrue, M. Sabatelli, K. Williams, M. Stevens, V. Maria, M. Comabella, C. Lammers, R. M. L. Poublon, E. Tizzano, P. Pazzaglia, F. Zoeller, M. B. Delisle, J. P. Goument, J. M. Minderhoud, A. Sghirlanzoni, V. Meininger, M. Al Deeb, C. Bertelt, A. Cagni, A. Algra, F. Morales, K. A. Flugel, M. Maidani, M. Noya, Z. Seidl, U. Roelcke, D. Cannata, E. Katiane EmbiruÇu, E. M. Wicklein, K. Willmes, L. Hanoglu, J. F. Pellissier, Yves Agid, E. Cuadrado, S. Brock, D. Maimone, Z. G. Nadareishvili, E. Matta, S. Hilmi, V. Assuerus, F. Lomena, R. Springer, F. Cabrera-Valdivia, Oscar L. Lopez, M. Casazza, F. Vivancos, Ralf Gold, T. Crawford, B. Moulard, M. Poisson, W. l. McDonald, D. E. Grobbe, Alan Connelly, H. Ozcan, S. Abeta, H. Severo Ochoa, A. C. van Loenen, E. Libson, M. J. Marti, B. George, C. Ferrarese, B. Jacobs, L. Divano, T. Ben-Hur, A. L. Bootsma, V. Martinez, A. Conti, R. P. Maguire, B. Schmidt, D. M. Campos, D. A. Guzman, E. Meary, C. Richart, P. B. Christensen, T. Schroeder, Massimo Zeviani, K. Jensen, R. Aliaga, S. Seitz-Dertinger, J. W. Griffin, C. Fryze, H. Baas, S. Braun, A. M. Porrini, B. Yemez, M. J. Sedano, C. Creisson, A. Del Santo, A. Mainz, R. Kay, S. Livraghi, R. de Waal, D. Macgregor, H. Hefter, R. Garghentino, U. Ruotsalainen, M. Matsumoto, M. G. Beaudry, P. M. Morrison, J. C. Petit, C. Walon, Ph. Chemouilli, F. Henderson, R. Massa, A. Cruz Martinez, U. Liska, F. Hecht, Ernst Holler, V. S. de Bruin, B. B. Sheitman, S. M. Bentzen, C. Bayindir, F. Pallesta, P. E. Roland, J. Parrilla, P. Zunker, L. F. Burchinskaya, G. Mellino, S. Ben Ayed, D. Bonneau, P. Nowacki, M. Goncalves, P. Riederer, N. Mavroudakis, J. Togores, L. Rozewicz, S. Robeck, Y. Perez Gilabert, L. Rampello, A. Rogopoulos, S. Martinez, F. Schildermans, C. Radder, P. B. Hedlund, J. Cambier, M. Aabed, G. D. Jackson, P. Gasparini, P. Santacruz, J. Vandevivere, H. Dural, A. Mantel, W. Dorndorf, N. Ediboglu, A. Lofgren, J. Bogousslavsky, P. Thierauf, L. Goullard, R. Maserati, B. Moering, M. Ryba, J. Serra, G. G. Govan, A. Pascual-Leone, S. Schaeffer, M. R. Rosenfeld, A. P. Correia, K. Ray Chaudhuri, L. Campbell, R. Spreafico, B. Genetet, A. M. Tantot, R. A. G. Hughes, J. A. Vidal, G. Erkol, J. Y. Delattre, B. Yaqub, B. K. Hecht, E. Mayayo, Ph. Scheltens, J. Corral, M. Calaf, L. Henderson, C. Y. Li, U. Bogdahn, R. Sanchez-Roy, M. Navasa, J. Ballabriga, G. Broggi, T. Gudeva, C. Rose, J. Vion-Dury, J. A. Gastaut, J. Pniewski, Nicola J. Robertson, G. Kohncke, M. Billot, S. Gok, E. Castellli, F. Denktas, P. Bazzi, F. Spinelli, I. F. Moseley, C. D. Mardsen, B. Barbiroli, O. M. Koriech, A. Miller, Hiroaki Yoshikawa, F. X. Borruat, J. Zielasek, P. Le Coz, J. Pascual, A. Drouet, L. T. Giron, F. Schondube, R. Midgard, M. Alizadeh, M. Liguori, Lionel Ginsberg, L. Harms, C. Tilgner, G. Tognoni, F. Molteni, Mar Tintoré, M. Psylla, C. Goulon-Goeau, M. V. Aguilar, Massimo Filippi, K. H. Mauritz, Thomas V. Fernandez, C. Basset, S. Rossi, P. Meneses, B. Jandolo, T. Locatelli, D. Shechtcr, C. Magnani, R. Ferri, Bruno Dubois, J. M. Warier, S. Berges, F. Idiman, M. Schabet, R. R. Diehl, P. D'aurelio, M. Musior, Reinhard Hohlfeld, P. Smeyers, M. Olivé, A. Riva, C. A. Broere, N. Egund, S. Franceschetti, V. Bonavita, Nicola Canal, E. Timmermans, M. Ruiz, S. Barrandon, G. Vasilaski, B. Deweer, L. Galiano, S. F. T. M. de Bruijn, L. Masana, A. Goossens, B. Heye, K. Lauer, Heinz Gregor Wieser, Stephen R. Williams, B. Garavaglia, A. P. Sempere, F. Grigoletto, P. Poindron, R. Lopez-Pajares, I. Leite, T. A. McNell, C. Caucheteur, J. M. Giron, A. D. Collins, P. Freger, J. Sanhez Del Rio, D. A. Harn, K. Lindner, S. S. Scherer, G. Serve, M. Juncadella, X. Estivill, R. Binkhorst, M. Anderson, B. Tekinsoy, C. Sagan, T. Anastopoulos, G. Japaridze, S. Guillou, F. Erminio, Jon Sussman, P. G. Oomes, D. S. Rust, S. Mascheroni, O. Berger, M. Peresson, K. V. Toyka, T. W. Polder, M. Huberman, B. Arpaci, H. Ramtami, I. Martinez, Ph. Violon, P. P. Gazzaniga Pozzill, R. Ruda, P. Auzou, J. Parker, S. P. Morrissey, Jiahong Zhu, F. Rotondi, P. Baron, W. Schmid, P. Doneda, M. Spadaro, M. C. Nargeot, I. Banchs, J.S.P. van den Berg, R. Ferrai, M. Robotti, M. Fredj, Pedro M. Rodríguez Cruz, B. Erne, D. G. Piepgras, M. C. Arne-Bes, J. Escudero, C. Goetz, A. R. Naylor, M. Hallett, O. Abramsky, E. Bonifacio, L. E. Larsson, R. Pellikka, P. Valalentino, D. Guidetti, B. Buchwald, C. H. Lücking, D. Gauvreau, F. Pfaff, A. Ben Younes-Chennoufi, R. Kiefer, R. Massot, K. A. Hossmann, L. Werdelin, P. J. Baxter, U. Ziflo, S. Allaria, C. D. Marsden, M. Cabaret, S. P. Mueller, E. Calabrese, R. Colao, S. I. Bekkelund, M. Yilmaz, O. Oktem-Tanor, R. Gine, M. E. Scheulen, J. Beuuer, A. Melo, Z. Gulay, M. D. Have, C. Frith, D. Liberati, J. Gozlan, P. Rondot, Ch. Brunholzl, M. Pocchiari, J. Pena, L. Moiola, C. Salvadori, A. Cabello, T. Catarci, S. Webb, C. Dettmers, N. A. Gregson, Alexandra Durr, F. Iglesias, U. Knorr, L. Ferrini-Strambi, F. Kruggel, P. Allard, A. Coquerel, P. Genet, F. Vinuels, C. Oberwittler, A. Torbicki, P. Leffers, B. Renault, B. Fauser, C. Ciano, G. Uziel, J. M. Gibson, F. Anaya, C. Derouesné, C. N. Anagnostou, M. Kaido, W. Eickhoff, G. Talerico, M. L. Berthier, A. Capdevila, M. Alons, D. Rezek, E. Wondrusch, U. Kauerz, D. Mateo, M. A. Chornet, Holon, N. Pinsard, I. Doganer, E. Paoino, H. Strenge, C. Diaz, J. R. Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg
Subjects: Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published: 1994
Full Text: View/download PDF

45. Contents, Vol. 11, 1994

Author: M.W. Büchler, P. Vock, L. Fernández-Cruz, St. Hürlimann, Michael S. Kobrin, Dik J. Kwekkeboom, Holger Kalthoff, H.G. Beger, Rudolf W. Ammann, H. Friess, S. Gonzalez, H. Frieß, Myriam Delhaye, Alain Vandermeeren, Wolff Schmiegel, Jacques Devière, L. Salvador, Ch.A. Seller, V. Di Carlo, M. Prados, S.R. Bramhall, Markus W. Büchler, Sven N. Reske, Leslie I. Gold, Jean Claude Reubi, K.-H. Link, Jakob R. Izbicki, M. Wagner, Parviz M. Pour, Gerhard Glatting, W. Uhl, K. Gyr, J.E.J. Krige, Helmut Friess, Dale E. Bockman, Canton J. Young, Jens C. Stollfuss, M. Falconi, Guido Adler, L. De Santis, Gisli H. Sigurdsson, I.M. Modlin, Michael G. Sarr, Jon S. Odorico, K.E. Gyr, H.U. Baer, Waldemar Uhl, Nicholas A. Wright, Michel Cremer, Hans Weidenbach, J. Lange, David L. Can-Locke, P. Aeberhard, Jan Axelson, R.F. Meier, E. Caldiron, C.W. Imrie, Arthur Zimmermann, Peter Malfertheiner, G.P. Lawton, Ch. Stoupis, P. Pederzoli, Christian Roeder, Günter Klöppel, Ch. Becker, J. Pillasch, M. Ebert, M. Thumshirn, Gregor Dornschneider, Adrian Schmassmann, Jürgen Triller, B. Hofbauer, Wolfram T. Knoefel, Susanne Liptay, E. Astudillo, Eugene P. DiMagno, S.A. Sgambati, Werner Inauen, P.C. Bornman, A.M. Wheatley, J.P. Neoptolemos, Peter A. Banks, Jean-Marc Dumonceau, Ulrich Scheurer, Wilker Dk, S. Navarro, F. Largiadèr, Michel Baize, Hans G. Beger, N. Sartori, N. Rilinger, Enrique Domínguez-Muñoz, Ingemar Ihse, Michael W. Müller, C. Bassi, Jan Schmielau, Howard A. Reber, Charles F. Frey, Roland M. Schmid, Larry K. Kvols, Murray Korc, Katsumi Amikura, M.M. Lerch, Hans W. Sollinger, F. Halter, G. Adler, Nicholas R. Lemoine, Kurt G. Grillenberger, Fred Halter, H.-J. Schrag, F. Gansauge, Andrzej S. Tarnawski, Åke Andrén-Sandberg, C. Socci, T. Obeid, Eric P. Krenning, Christian Bloechle, Khalid Al-Sharaf, A. Saenz, Stanislas Pauwels, and Christoph E. Broelsch
Subjects: Traditional medicine, business.industry, Gastroenterology, Medicine, Surgery, business
Published: 1994
Full Text: View/download PDF

46. Islet Cell Transplantation

Author: V. Di Carlo and Carlo Socci
Subjects: endocrine system, Islet cell transplantation, geography, geography.geographical_feature_category, endocrine system diseases, Mechanism (biology), business.industry, medicine.medical_treatment, Gastroenterology, Immunosuppression, Islet, Immunology, medicine, Surgery, business
Abstract: The important advances made in islet separation techniques, in understanding the immunological mechanism of islet rejection, in immunosuppression strategies made it possible to start clinical trials o
Published: 1994
Full Text: View/download PDF

47. Pancreas and kidney transplantation: the San Raffaele Hospital (Milan, Italy) experience

Author: S. Martinenghi, V. Di Carlo, G. Gallioli, Michele Carlucci, Renato Castoldi, Carlo Staudacher, Antonio Secchi, Rossana Caldara, E. La Rocca, M. Cristallo, Giuliana Ferrari, G. Torri, C. Martani, Guido Pozza, V., Di Carlo, C., Staudacher, M., Cristallo, G., Ferrari, M., Carlucci, R., Castoldi, Secchi, Antonio, E., La Rocca, S., Martinenghi, R., Caldara, G., Gallioli, C., Martani, G., Torri, and G., Pozza
Subjects: Adult, Graft Rejection, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Postoperative Complications, Internal Medicine, Humans, Medicine, In patient, Kidney transplantation, Immunosuppression Therapy, Kidney, business.industry, General surgery, Follow up studies, Immunosuppression, Human physiology, medicine.disease, Kidney Transplantation, Thrombosis, Surgery, Diabetes Mellitus, Type 1, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, Italy, business, Pancreas, Follow-Up Studies
Abstract: Results of 33 simultaneous pancreas and kidney transplantations performed at the San Raffaele Hospital, Milan, Italy are presented. In 26 cases segmental neoprene duct-injected grafts were transplanted and in seven cases, duodenopancreatic bladder-drained grafts. Five-year patient, kidney and pancreas survival were respectively, 89%, 72% and 58%. Five-year survival in patients with technically successful pancreas transplants was 73%. Thrombosis occurred in 20% of cases. Mortality was 6% and overall morbidity 76%. Surgical complications were present in 51% of cases.
Published: 1991
Full Text: View/download PDF

48. Pancreata From Pediatric Donors Restore Insulin Independence in Adult Insulin-Dependent Diabetes Mellitus Recipients

Author: Andrea Caumo, Elena Orsenigo, Carlo Staudacher, Matteo Frasson, R. Castoldi, Luca Ghirardelli, V. Di Carlo, D. Parolini, M. Carvello, I. Santagostino, Antonio Secchi, Carlo Socci, Rossana Caldara, Luca Aldrighetti, Socci, C., Orsenigo, E., Santagostino, I., Caumo, A., Caldera, R., Parolini, D., Aldrighetti, L, Castoldi, R., Frasson, M., Carvello, M., Ghirardelli, L., Secchi, A., Di Carlo, V., and Staudacher, C.
Subjects: Adult, Blood Glucose, medicine.medical_specialty, Time Factors, Adolescent, medicine.medical_treatment, Population, Islets of Langerhans Transplantation, Pancreas transplantation, Gastroenterology, Tacrolimus, Internal medicine, Diabetes mellitus, Insulin Secretion, medicine, Humans, Insulin, education, Child, Survival rate, Transplantation, Type 1 diabetes, education.field_of_study, Glucose tolerance test, medicine.diagnostic_test, business.industry, Graft Survival, Glucose Tolerance Test, Mycophenolic Acid, medicine.disease, Tissue Donors, Surgery, Survival Rate, Diabetes Mellitus, Type 1, Pancreas Transplantation, business, Immunosuppressive Agents, Follow-Up Studies
Abstract: Context The use of pediatric donors can increase the number of donors available for pancreas transplantation. Aim The aim of this study was to verify if pancreas transplantation from pediatric donors is as effective as transplantation from adult donors to restore metabolic control in type 1 diabetic patients. Materials and Methods From 2000 to April 2009 we performed 17 pancreas transplantations from pediatric donors: 9 simultaneous kidney-pancreas (SPK), 6 pancreas transplantation alone (PTA), and 2 pancreas after kidney (PAK). All subjects received whole organs with enteric diversion of exocrine secretions; 11 underwent systemic and 6 underwent portal venous graft drainage. The immunosuppressive therapy was as follows: prednisone, mycophenolate mofetil, anti-thymocyte globulin (ATG), and cyclosporine or tacrolimus. The pediatric donor population had a mean age of 15.3 years (range, 12–17), a mean weight of 60.1 kg (range, 42–75), and a mean body mass index (BMI) of 21 (range, 17.9–23.4). Results After 9 years the overall patient survival rate was 94.12%, whereas the graft survival rate was 63.35%. Normal glucose and insulin levels were maintained either fasting or during oral glucose tolerance test (OGTT). The group of recipients of pediatric organs was compared with patients receiving organs from adult donors (n = 125); the mean glucose values were lower in the pediatric group, whereas insulin production was higher in the adult patients. Early venous thrombosis was 17.6% in the pediatric group and 20% in adult recipients (Fisher exact test, P = not significant [NS]). Conclusion Pediatric donors restored insulin independence in adult diabetic recipients, representing a valid source of organs for pancreas transplantation.
Published: 2010

49. Randomized clinical trial of laparoscopic versus open left colonic resection

Author: N. Pecorelli, Matteo Frasson, V. Di Carlo, Walter Zuliani, Marco Braga, Andrea Vignali, Braga, Marco, Frasson, M, Zuliani, W, Vignali, Andrea, Pecorelli, N, Di Carlo, V., Braga, M, Vignali, A, and Di Carlo, V
Subjects: Male, medicine.medical_specialty, Randomization, Colon, medicine.medical_treatment, Cost-Benefit Analysis, Kaplan-Meier Estimate, Disease-Free Survival, law.invention, Postoperative Complications, Randomized controlled trial, law, Colon surgery, medicine, Humans, Cost-Benefit Analysi, Laparoscopy, Survival rate, Colectomy, Colonic Neoplasm, medicine.diagnostic_test, business.industry, Mortality rate, Length of Stay, Middle Aged, Surgery, Clinical trial, Colonic Neoplasms, Quality of Life, Female, Postoperative Complication, business, Human
Abstract: Background The main aim of this study was to compare short-term results and long-term outcomes of patients undergoing laparoscopic versus open left colonic resection. Methods Between February 2000 and December 2004, all adult patients undergoing elective left colonic resection were assessed for eligibility to the study. The protocol for postoperative care was the same in both groups. Cost–benefit analysis was based on hospital costs. Quality of life, long-term morbidity and 5-year survival were also evaluated. Results Some 268 patients undergoing left colonic resection were assigned randomly to the laparoscopic (n = 134) or open (n = 134) approach. The short-term morbidity rate was 20·1 per cent in the open group and 11·9 per cent in the laparoscopic group (P = 0·094). Hospital stay was longer in the open group (8·7 versus 7·0 days for the laparoscopic approach; P = 0·002). Cost–benefit analysis showed an additional cost of €66 per patient randomly allocated to the laparoscopic group. Quality of life was significantly improved in the laparoscopic group 6 months after surgery, but no difference was found subsequently. The long-term morbidity rate was 11·9 per cent in the open group and 7·5 per cent in the laparoscopic group (P = 0·413). The 5-year survival rate of patients with cancer was 66 and 72 per cent for open and laparoscopic groups respectively (P = 0·321). Conclusion Laparoscopic left colonic resection resulted in an earlier recovery after surgery. As cost–benefit analysis and long-term follow-up showed similar results, the laparoscopic approach should be preferred to open surgery. Registration number: NCT00894725 (http://clinicaltrials.gov).
Published: 2010

50. Evaluation of the Predictive Performance of Nutritional Indicators by Receiver-Operating Characteristic Curve Analysis

Author: S. Dal Cin, Luca Gianotti, M. Cristallo, Marco Braga, Giovanni Radaelli, V. Di Carlo, P. Baccari, Braga, M, Gianotti, L, Radaelli, G, Cristallo, M, Baccari, P, Dal Cin, S, and Di Carlo, V
Subjects: Male, Esophageal Neoplasms, 030309 nutrition & dietetics, Youden's J statistic, Medicine (miscellaneous), Gastroenterology, Leukocyte Count, 0302 clinical medicine, Weight loss, Neoplasms, Cholinesterases, Cutoff, Lymphocytes, Esophageal Neoplasm, Aged, 80 and over, Colonic Neoplasm, 0303 health sciences, Nutrition and Dietetics, Serum cholinesterase, Pancreatic Neoplasm, Nutritional status, Middle Aged, Prognosis, Nutritional Statu, Colonic Neoplasms, Lymphocyte, Female, 030211 gastroenterology & hepatology, medicine.symptom, Human, Protein Binding, Adult, medicine.medical_specialty, Prognosi, Iron, Nutritional Status, 03 medical and health sciences, Stomach Neoplasm, Stomach Neoplasms, Internal medicine, Weight Loss, medicine, Humans, Serum Albumin, Aged, Rectal Neoplasm, Receiver operating characteristic, Rectal Neoplasms, business.industry, Perioperative, Cholinesterase, Weight Lo, Pancreatic Neoplasms, Parenteral nutrition, Endocrinology, Neoplasm, business
Abstract: Four hundred twenty-two cancer patients who underwent major surgery were studied. At admission, nutritional status was evaluated in all patients by assessing serum albumin (SA), total iron-binding capacity (TIBC), total lymphocyte count (TLC), serum cholinesterase activity (CHE), and weight loss (WL). All patients received perioperative short-term antibiotic prophylaxis and postoperative total parenteral nutrition. Prognostic ability of nutritional indicators was assessed by receiver-operating characteristic (ROC) curve analysis. The area beneath the ROC curve (Az) is an index of predictor performance when its value ranges from 0.5 (chance performance) to 1 (perfect prediction). Specificity, sensitivity, Youden index, and predictive values were determined for each nutritional parameter within a wide range of potential threshold values. Postoperative septic complications were observed in 85 (20.14%) patients. The Az values for the considered nutritional parameters ranged from 0.52 to 0.57 and that showed the low predictive ability of the parameters. When sensitivity and specificity for each nutritional parameter were examined at different thresholds, a clearly more predictive cutpoint was not observed, but ranges of values with a similar predictivity were observed. Significant ranges of predictivity were found for SA (33 to 35 g/L), for TIBC (2200 to 2300 micrograms/L), for TLC (2100 to 2200 million/L), for CHE (1700 to 1900 U/L), and for WL (7% to 12%). The higher values of Youden index were as follows: 1.183 for WL (cutoff 11%), 1.150 for TLC (cutoff 2100 million/L), and 1.145 for SA (cutoff 35 g/L). In conclusion, ROC curve analysis showed that the nutritional parameters had a low predictive ability.(ABSTRACT TRUNCATED AT 250 WORDS)
Published: 1991
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

694 results on '"V (Di, Carlo"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources