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We studied the blood and plasma viscosity and hematocrit in patients with ischemic stroke and in a control group. Patients with ischemic stroke had a marked hyperviscosity and elevated hematocrit levels which were correlated with arterial hypertension, alcohol consumption and tobacco smoking. In women aged 45-55 years, viscosity and hematocrit were correlated with age that may be explained by the hormonal changes. People with ischemic stroke had three variants of circadian patterns of viscosity and hematocrit with peaks at 9 am, 3 pm and 9 pm. In some patents a strong correlation between the time of stroke onset and circadian pattern was observed.

The study evaluates efficacy of two hyperbaric therapeutic regimes--1,-51,1 atm and 1,2 atm in patients with an acute ischemic stroke. Acid-base equilibrium dynamics of capillary and venous blood, whole blood and plasma, platelet aggregation and lipid peroxidation were investigated. An analysis of the data revealed that, comparing to the conventional method, barotherapy in stroke is accompanied by a marked therapeutic effect. Barotherapy or normoxic therapeutic compression is principally different from other methods of oxygen therapy, because it is not resultant in blood plasma hyperoxygenation and in lipid peroxidation augmenting. Activation of tissue respiration in barotherapy accompanied by normalization of lipid peroxidation process and CO2 resources restoration leads to renewal of MKT microcirculation and autoregulation, thus providing a stable therapeutic effect of the method in brain ischemia.

In 20 patients with ischemic stroke and moderate or severe arterial hypertension the effectiveness of eprosartan mesilat (Teveten, Solway Farma, Germany) for a period of 6 months was studied. Patients received 600 mg of eprosartan mesilat daily and in 4 cases hydrochlortyaside was also added. Monotherapy with eprosartan mesilat was effective in all patients with moderate arterial hypertension and in 43.6% in patients with severe arterial hypertension. Therapy with eprosartan mesilat was associated with significant hypotensive effect (more evident in patients with high systolic blood pressure), improvement in 24-hour blood pressure profile and quality of life, and lower probability of secondary stroke. Side effects were not observed.

Examination of 64 patients with prior pulmonary artery thromboembolism revealed high blood viscosity in 88% of males and 77% of females. Polycythemia and disturbed erythrocyte deformability were the causes of increased blood viscosity. The degree of disturbed blood viscosity correlated with the degree of hemodynamic disorders. The development of the blood hyperviscosity syndrome was determined by the extent of the affected lungs rather than by the duration of the disease.

Based on studying 34 patients, the authors made a conclusion that transfusion of UVI autoblood improves the pulmonary blood circulation, increases blood oxygenation and deformability of erythrocytes, decreases blood viscosity.

The rheologic blood properties were studied in patients with acute venous thrombosis during Arvin therapy. A marked correcting effect of the agent in removing the hemorheological disorders was demonstrated. It was found that the action of Arvin, linked with reduction of fibrinogen concentration, is attended by a decrease of blood viscosity, diminished aggregation of blood formed elements, and improvement of the functional condition of the microcirculatory bed during the whole course of treatment. The duration of the positive hemorheological effect of Arvin exceeds that in treatment by a complex of antithrombotic agents.

Reinfusion of the blood irradiated with the ultra-violet rays in patients with chronic insufficiency of the blood supply of the extremities leads to significant increase in the linear and volumetric blood flow rate in the damaged extremities, improvement in the microcirculation, reduction in the blood viscosity. The effect doesn't depend on the genesis of occlusion and degree of the impairement of circulation.

Examination of 38 patients with chronic postembolic pulmonary hypertension revealed gross hemorheological disorders: increased viscosity of blood, extreme aggregation activity of blood cells, diminished property or erythrocytes to undergo deformity when circulating through the capillaries. Small amounts of UV-irradiated autologous blood were infused repeatedly for the correction of these disorders. After a course of treatment the hemorheological indices were normalized in all the patients, which was attended by improvement of the general condition and positive hemodynamic shifts.

Examination of 138 patients with acute venous thrombosis of the lower limbs, which was complicated by thromboembolism of the pulmonary artery in 49 of them, showed the rheologic status to be disturbed to a greater extent in patients with pulmonary embolism than in those with acute venous thrombosis. An interrelationship between the rheologic properties and the coagulation system of the blood in various conditions of the hemostasis system was revealed. It is pointed out that pathogenetically grounded correction of the disorders of the blood coagulation and rheologic systems is necessary in choosing the method for treatment and prevention of acute venous thrombosis and pulmonary embolism.

Studies of orthostatic effects on the renal hemodynamics and excretory function of the dog showed an increase in the heart rate, a fall in the arterial and venous pressure and a decline of the Na and K concentrations in the urine. The studies demonstrated that changes in the renal excretory function were a compensatory hemodynamic reaction to the gravity effect associated wtih an alteration of the body position in space.

The rheological properties of blood (viscosity, thrombocyte and erythrocyte aggregation activity, ability of erythrocytes for deformation) were studied in 49 patients subjected to surgical operation of different duration and volume of blood loss. It was found that a surgical trauma causes alterations in rheological properties of blood. The degree of hemorheological deviations was shown to correlate with the severity of surgery. In order to reduce the amount of postoperative complications in the patients it is necessary to investigate the main rheological parameters and their correction.