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1. Three-dimensional cone beam computed tomography analysis protocols for condylar remodelling following orthognathic surgery: a systematic review

Author

Eman Shaheen, Sohaib Shujaat, L. Verstraete, P.-J. Verhelst, Reinhilde Jacobs, Constantinus Politis, Gwen R.J. Swennen, and V. Darche

Subjects
Cone beam computed tomography, medicine.medical_treatment, Orthognathic surgery, 3d model, computer.software_genre, Condyle, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, stomatognathic system, Voxel, 3d segmentation, medicine, Humans, Segmentation, Prospective Studies, three-dimensional analysis, Orthodontics, condylar remodelling, Orthognathic Surgical Procedures, business.industry, orthognathic surgery, Orthognathic Surgery, Mandibular Condyle, 030206 dentistry, cone beam computed tomography, Cone-Beam Computed Tomography, Temporomandibular joint, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, Surgery, Oral Surgery, business, computer
Abstract

Orthognathic surgery involving the mandible can lead to remodelling of the temporomandibular joint (TMJ). Cone beam computed tomography (CBCT) provides an easily accessible three-dimensional (3D) approach to study this entity. A systematic review of the literature was performed with the aim of identifying condylar remodelling analysis protocols using CBCT-derived 3D models. The search yielded 10 eligible studies. The systematic review identified three pillars of a condylar remodelling analysis protocol that were retrievable from each of the included studies: (1) registration, (2) segmentation, and (3) analysis. The studies lacked consensus on how these pillars should be transferred to their respective protocol. Through critical assessment, criteria for a universal condylar remodelling analysis are suggested: (1) performance of a regional voxel-based registration of baseline and postoperative CBCT scans using an anatomical region not prone to postoperative changes, (2) application of a (semi-)automated 3D segmentation algorithm, (3) performance of a combination of both volumetric and surface-based 3D condylar analysis, and (4) extensive validation of each step of the protocol. The homogenization of condylar remodelling analysis protocols and their incorporation into virtual planning software suites raises the potential for the inclusion of larger numbers of patients in future prospective studies in order to gain evidence-based data. ispartof: INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY vol:49 issue:2 pages:207-217 ispartof: location:Denmark status: published

Published
2020
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2. Osteonecrosis of the jaw in patients with inflammatory bowel disease treated with tumour necrosis factor alpha inhibitors

Author

Isabel Miclotte, Severine Vermeire, K. Brijs, Constantinus Politis, and V. Darche

Subjects
medicine.medical_specialty, Population, Tumour necrosis factor alpha, MRONJ, Gastroenterology, Inflammatory bowel disease, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, inflammatory bowel disease, Internal medicine, medicine, Humans, In patient, education, TNF-α inhibitors, education.field_of_study, Bone Density Conservation Agents, Diphosphonates, business.industry, Tumor Necrosis Factor-alpha, Osteonecrosis, 030206 dentistry, medicine.disease, Inflammatory Bowel Diseases, osteonecrosis of the jaw, Otorhinolaryngology, Sequestrectomy, 030220 oncology & carcinogenesis, Concomitant, Surgery, Bisphosphonate-Associated Osteonecrosis of the Jaw, Oral Surgery, Osteonecrosis of the jaw, business, Cohort study
Abstract

Previous reports have suggested a possible association between tumour necrosis factor alpha (TNF-α) inhibitors, used in the treatment of immune-mediated inflammatory diseases, and medication-related osteonecrosis of the jaw (MRONJ). However, a comprehensive assessment of the frequency and severity of MRONJ caused by these agents is lacking. The aim of this cohort study was to investigate the occurrence of MRONJ in a population of patients with inflammatory bowel disease (IBD) treated with TNF-α inhibitors at a tertiary care medical centre. A total of 2701 IBD patients under current or former treatment with TNF-α inhibitors were identified in an IBD registry covering the period 1994-2018. These patients were cross-matched with all patients diagnosed with MRONJ. This resulted in three patients with a definite diagnosis of MRONJ, without concomitant treatment with bisphosphonates. All three patients required surgical treatment with sequestrectomy. Mucosal healing occurred at 4-15 months and one patient developed recurrence. In conclusion, this study identified and described anti-TNF-α-related MRONJ occurring in a large cohort of IBD patients, and reported the severity and treatment strategies used. ispartof: INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY vol:49 issue:3 pages:317-324 ispartof: location:Denmark status: published

Published
2020

3. [Combination of successive free transplants and osseointegrated implants in the reconstruction of the upper jaw]

Author

V, Darche, P, Lejuste, and E, Piette

Subjects
Dental Implants, Male, Maxillary Neoplasms, Bone Transplantation, Esthetics, Dental Implantation, Endosseous, Skin Transplantation, Middle Aged, Surgical Flaps, Deglutition, Face, Maxilla, Humans, Mastication, Speech, Fascia, Muscle, Skeletal, Follow-Up Studies
Abstract

Various free flap transfers can be associated to reconstruct a defect after resections in the head and neck region. The use of these flaps can be synchronous (one-stage surgery) or metachronous (two-stage surgery) in order to correct or improve secondary residual deformities. A two-stage use of free flaps, first with an osteocutaneous scapular flap and second with a fascial radial forearm flap, is reported after total maxillectomy. The osteocutaneous scapular flap was used to restore function (swallowing, chewing, speech and cheek projection) and the radial forearm flap to improve esthetic facial morphology. Minor ancillary procedures were subsequently necessary to achieve the final result (brow lift, tarsal straightening and facial lift).

Published
1999

4. [A case of very late malignant degeneration of pleomorphic adenoma]

Author

V, Darche, J, Hustin, P, Lejuste, T, Robillard, and E, Piette

Subjects
Adult, Time Factors, Adenoma, Pleomorphic, Neoplasms, Second Primary, Radiotherapy Dosage, Adenocarcinoma, Prognosis, Salivary Gland Neoplasms, Combined Modality Therapy, Mixed Tumor, Malignant, Carcinoma, Squamous Cell, Humans, Female, Neoplasm Recurrence, Local, Follow-Up Studies
Abstract

Incomplete excision of a pleomorphic adenoma exposes to a high risk of recurrence and tumor spread, making secondary surgery more difficult or a malignant transformation with a poor vital prognosis likely. Three histological types of pleomorphic adenomas can be observed when the tumor undergoes a transformation, namely the carcinoma ex-pleomorphic adenoma, the true malignant mixed tumor and the benign metastasizing mixed tumour.

Published
1999

5. [Central odontogenic fibroma: apropos of a case]

Author

V, Darche, F, Lambert, E, Marbaix, and H, Reychler

Subjects
Adult, Male, Mandibular Neoplasms, Radiography, Panoramic, Humans, Odontogenic Tumors, Tomography, X-Ray Computed
Published
1995

6. [Medical symptomatology and integrated therapeutic planning at the level of handicapped children]

Author

C, Demars-Fremault, A, Fortpied, and V, Darche

Subjects
Adult, Epilepsy, Spinal Injuries, Brain Injuries, Intellectual Disability, Humans, Disabled Persons, Neuromuscular Diseases, Nervous System Diseases, Child, Cognition Disorders
Abstract

The knowledge of the neurological diseases is an essential factor to establish a relation between the practitioner and the child or the handicapped adult. The authors suggest to describe some pathologies with a particular attention for the keywords to realize a concerted management.

Published
1995

7. Osteonecrosis of the jaw in patients with inflammatory bowel disease treated with tumour necrosis factor alpha inhibitors.

Author

Brijs K, Miclotte I, Vermeire S, Darche V, and Politis C

Subjects
Cohort Studies, Diphosphonates, Humans, Tumor Necrosis Factor-alpha, Bisphosphonate-Associated Osteonecrosis of the Jaw, Bone Density Conservation Agents, Inflammatory Bowel Diseases, Osteonecrosis
Abstract

Previous reports have suggested a possible association between tumour necrosis factor alpha (TNF-α) inhibitors, used in the treatment of immune-mediated inflammatory diseases, and medication-related osteonecrosis of the jaw (MRONJ). However, a comprehensive assessment of the frequency and severity of MRONJ caused by these agents is lacking. The aim of this cohort study was to investigate the occurrence of MRONJ in a population of patients with inflammatory bowel disease (IBD) treated with TNF-α inhibitors at a tertiary care medical centre. A total of 2701 IBD patients under current or former treatment with TNF-α inhibitors were identified in an IBD registry covering the period 1994-2018. These patients were cross-matched with all patients diagnosed with MRONJ. This resulted in three patients with a definite diagnosis of MRONJ, without concomitant treatment with bisphosphonates. All three patients required surgical treatment with sequestrectomy. Mucosal healing occurred at 4-15 months and one patient developed recurrence. In conclusion, this study identified and described anti-TNF-α-related MRONJ occurring in a large cohort of IBD patients, and reported the severity and treatment strategies used., (Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Published
2020
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8. Accuracy of Computer-Aided Design/Computer-Aided Manufacturing-Assisted Mandibular Reconstruction With a Fibula Free Flap.

Author

Geusens J, Sun Y, Luebbers HT, Bila M, Darche V, and Politis C

Subjects
Aged, Computer-Aided Design, Female, Humans, Male, Mandible surgery, Middle Aged, Plastic Surgery Procedures, Surgery, Computer-Assisted methods, Tomography, X-Ray Computed, Fibula surgery, Free Tissue Flaps, Mandibular Reconstruction
Abstract

Background: The recent increase in computer-aided design and computer-aided manufacturing (CAD/CAM)-assisted surgery has warranted a thorough evaluation of the accuracy of virtual plan execution. Mandibular reconstructions with a fibula free flap were evaluated by comparing the fibular segments postoperatively with the virtual surgical plans., Methods: This study included computed tomography data for 20 patients (11 males; mean age 61.3 years, range 47-74) that received a mandibular reconstruction with a fibula free flap. Linear distances (superior and inferior borders) of 41 fibula segments and intercoronoid distances were measured., Results: The mean difference was 3.11 ± 2.80 mm for superior borders (range 0.02-12.20 mm), and 2.75 ± 2.61 mm for inferior borders (range 0.22-13.58 mm). The mean intercoronoid difference was 3.57 ± 1.80 mm (range 0.91-6.11 mm)., Conclusion: This study confirmed the presumed accuracy regarding the use of fibular and mandibular cutting guides. CAD/CAM is an attractive technique which enhances efficiency and assurance during surgery and preoperative planning.

Published
2019
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9. [The dentist, invaluable assistant in the diagnosis of Silverman Tardieu syndrome].

Author

Delheusy G, Darche V, and Demars Fremault C

Subjects
Child, Humans, Maxillofacial Injuries diagnosis, Professional Role, Syndrome, Child Abuse diagnosis, Dentists
Abstract

Many practitioners are still unawared of the oral and maxillo-facial pathology due to physical and sexual maltreatments of children. Yet more than fifty percent of those battered children show oro-facial injuries. Dentists ought to contribute to the diagnosis of the Silverman Syndrome and involve themselves in the taking care of battered children.

Published
2004

10. [A case of very late malignant degeneration of pleomorphic adenoma].

Author

Darche V, Hustin J, Lejuste P, Robillard T, and Piette E

Subjects
Adenocarcinoma radiotherapy, Adenocarcinoma surgery, Adenoma, Pleomorphic surgery, Adult, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell surgery, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Mixed Tumor, Malignant radiotherapy, Mixed Tumor, Malignant surgery, Neoplasm Recurrence, Local, Neoplasms, Second Primary radiotherapy, Neoplasms, Second Primary surgery, Prognosis, Radiotherapy Dosage, Salivary Gland Neoplasms radiotherapy, Salivary Gland Neoplasms surgery, Time Factors, Adenocarcinoma pathology, Adenoma, Pleomorphic pathology, Carcinoma, Squamous Cell pathology, Mixed Tumor, Malignant pathology, Neoplasms, Second Primary pathology, Salivary Gland Neoplasms pathology
Abstract

Incomplete excision of a pleomorphic adenoma exposes to a high risk of recurrence and tumor spread, making secondary surgery more difficult or a malignant transformation with a poor vital prognosis likely. Three histological types of pleomorphic adenomas can be observed when the tumor undergoes a transformation, namely the carcinoma ex-pleomorphic adenoma, the true malignant mixed tumor and the benign metastasizing mixed tumour.

Published
1998

11. [Combination of successive free transplants and osseointegrated implants in the reconstruction of the upper jaw].

Author

Darche V, Lejuste P, and Piette E

Subjects
Bone Transplantation, Deglutition physiology, Esthetics, Face surgery, Fascia transplantation, Follow-Up Studies, Humans, Male, Mastication physiology, Maxillary Neoplasms rehabilitation, Middle Aged, Muscle, Skeletal transplantation, Skin Transplantation, Speech physiology, Dental Implantation, Endosseous, Dental Implants, Maxilla surgery, Maxillary Neoplasms surgery, Surgical Flaps
Abstract

Various free flap transfers can be associated to reconstruct a defect after resections in the head and neck region. The use of these flaps can be synchronous (one-stage surgery) or metachronous (two-stage surgery) in order to correct or improve secondary residual deformities. A two-stage use of free flaps, first with an osteocutaneous scapular flap and second with a fascial radial forearm flap, is reported after total maxillectomy. The osteocutaneous scapular flap was used to restore function (swallowing, chewing, speech and cheek projection) and the radial forearm flap to improve esthetic facial morphology. Minor ancillary procedures were subsequently necessary to achieve the final result (brow lift, tarsal straightening and facial lift).

Published
1998

12. [Central odontogenic fibroma: apropos of a case].

Author

Darche V, Lambert F, Marbaix E, and Reychler H

Subjects
Adult, Humans, Male, Mandibular Neoplasms pathology, Mandibular Neoplasms surgery, Odontogenic Tumors pathology, Odontogenic Tumors surgery, Radiography, Panoramic, Tomography, X-Ray Computed, Mandibular Neoplasms diagnostic imaging, Odontogenic Tumors diagnostic imaging
Published
1995

13. [Medical symptomatology and integrated therapeutic planning at the level of handicapped children].

Author

Demars-Fremault C, Fortpied A, and Darche V

Subjects
Adult, Brain Injuries classification, Child, Cognition Disorders classification, Epilepsy classification, Humans, Intellectual Disability classification, Neuromuscular Diseases classification, Spinal Injuries classification, Persons with Disabilities classification, Nervous System Diseases classification
Abstract

The knowledge of the neurological diseases is an essential factor to establish a relation between the practitioner and the child or the handicapped adult. The authors suggest to describe some pathologies with a particular attention for the keywords to realize a concerted management.

Published
1995

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