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The objective : to provide pathogenetic justification for the need for extracorporeal blood purification in the new coronavirus infection. Results : the article analyzes guidelines and the first experience of using extracorporeal methods in the new coronavirus infection in different countries. It has been demonstrated that methods of extracorporeal blood purification have complex pleiotropic (multiple) effects and can quickly normalize the level of cytokines and other pathogenic factors, thereby preventing/reducing the severity of organ disorders. The article specifies the criteria for choosing an extracorporeal method, as well as indications for its early and late use.

In the development of life support systems for long-term space missions, the most important tasks are the absorption of carbon dioxide from the air, the production of carbon dioxide with a concentration above 98 %, and the production of oxygen from carbon dioxide by the Bosch – Sabatier process. To solve these problems, a regenerative carbon dioxide absorber adapted to space flight conditions is required. The article proposes a new method for the production of chemosorbents based on hydrated zirconium oxide using polyacrylates as a binder and polymer matrix. The regenerated absorber of carbon dioxide for its application in space flights must meet the regulatory requirements of sanitary-chemical and toxicological safety of materials intended for the equipment of inhabited sealed rooms, be resistant to radiation and to the effects of mold. In the study of the processes of “sorption – desorption” of carbon dioxide, we have established the relationship between the technological parameters of the synthesis of chemosorbents and the kinetic parameters of the processes of mass-sorption of sorbate in the “sorption – regeneration” cycles. It is found that the optimal weight ratio of the “adsorbent – filler/polymer matrix” 89÷94/11÷6 is optimal in terms of the performance characteristics of the developed absorbers. It is shown experimentally that the main operational characteristics of the developed materials do not change under experimental conditions during 2000 “sorption – regeneration” cycles. The resulting chemosorbents are investigated by physicochemical analysis. Employing methods of gas chromatography and chromatomass spectrometry, we have conducted sanitary and chemical studies and toxicological assessment of the quantitative and qualitative composition of the components of gas release of the developed regenerated carbon dioxide absorber and air-gas mixture formed during the regeneration of the regenerated carbon dioxide absorber. Also we have carried out microbiological tests of samples of the regenerated absorber of carbon dioxide for resistance of material to influence of mold mushrooms. The results obtained confirm the possibility of using the developed materials in life support systems of manned spacecraft for deep space exploration.

We studied the composition of circulating immune complexes precipitated in the presence of various concentrations of polyethylene glycol in patients with coronary heart disease (CHD) and high concentration of lipoprotein(a) - Lp(a). Precipitation of highly purified Lp(a) preparation with polyethylene glycol was evaluated. The contents of Lp(a), autoantibodies to Lp(a), IgG, and IgM in circulating immune complexes isolated from the sera of donors and CHD patients with normal and high levels of Lp(a) were measured. Circulating immune complexes containing Lp(a) were detected in the plasma of CHD patients with high Lp(a) concentrations. The presence of high concentrations of Lp(a), autoantibodies to Lp(a), and circulating immune complexes in CHD patients suggests that immunological factor contributes to high atherothrombogenicity of Lp(a).

Carbon dioxide absorber based on hydrated zirconium oxide was synthesized with ammonium carbonate and hydrogen peroxide. The effect of the molar ratio between ammonium carbonate and hydrogen peroxide on the sorption characteristics of the absorber was examined. The structural-sorption properties of the absorber were analyzed. It was shown tat the absorber has a high absorption capacity for CO2.