1. LXR agonism for CNS diseases: promises and challenges
- Author
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Ruiyi Zhang, Emily Wuerch, V. Wee Yong, and Mengzhou Xue
- Subjects
Liver X receptor ,Neurological diseases ,Neuroinflammation ,Cholesterol metabolism ,Tissue regeneration ,Clinical translation ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regulate both processes due to its pivotal role in cholesterol metabolism and inflammatory response, and thus receives increasing attentions from neuroscientists and clinicians. Here, we summarize the signal transduction of LXR pathway, discuss the therapeutic potentials of LXR agonists based on preclinical data using different disease models, and analyze the dilemma and possible resolutions for clinical translation to encourage further investigations of LXR related therapies in CNS disorders. Graphical Abstract
- Published
- 2024
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