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In the course of searching new highly active substances which are prospective for treating tumors and some other types of widespread diseases the synthesis of protoporphyrin IX bearing the benzodiazepine residue, was performed. It was found that the use of porphyrins containing acetylacetonate residues in the heterocyclic synthesis leads to ketone splitting of the acetylacetonate moiety under the mild conditions of regioselective synthesis of benzodiazepine in addition to the formation of porphyrin-benzodiazepines.

Any variant of acute leukemia is characterized by a severe course of the disease, a high incidence of complications and mortality. For a long time, there was an opinion that when verifying hemoblastoses during pregnancy, its termination is required. Currently, studies and experience accumulated have shown that in most cases, a complete treatment of hemoblastosis can be carried out during pregnancy without the risk for developing any complications for both a mother and a fetus. The entire range of diagnostic studies is also carried out fully. The safety of pregnant women performing such diagnostically significant procedures as bone marrow puncture biopsy has been repeatedly confirmed. In most cases, a lumbar puncture with a study of the cerebrospinal fluid is also feasible to rule out leukemic lesions of the central nervous system. The choice of treatment tactics is carried out by a doctor depending on the type of hemoblastosis and its stage. The main methods of treatment include multicomponent chemotherapy, supportive treatment, replacement transfusion therapy, extracorporeal methods. In the first trimester, there is a high probability of an unfavorable outcome of pregnancy for both the mother and the fetus. But currently, polychemotherapy schemes have been developed that can be used in this period of pregnancy. The delivery period in patients with acute leukemia is determined individually. The resumption of special therapy is recommended not earlier than 3-4 weeks after birth in order to minimize the risk of developing infectious and hemorrhagic complications in the postpartum period. If it is necessary to continue chemotherapy in the postpartum period, lactation should be suppressed in the patient, since most drugs penetrate into mother's milk. The specific chemotherapy carried out does not exclude the possibility of developing various pathological conditions that can be regarded as complications of cytostatic therapy, because these conditions can also occur during a healthy pregnancy as a result of spontaneous mutations and the development of congenital anomalies in the fetus. In the 2ndand 3d trimesters, polychemotherapy is used with the drugs that are not able to overcome the hematoplacental barrier. Thus, the management of pregnancy in patients with acute leukemia is a difficult task, which is addressed by the joint efforts of hematologists and obstetricians and gynecologists.

Anemic syndrome is very widespread among the population. Among the pathogenetic variants, anemia of chronic diseases ranks second among various pathogenetic processes, such as prolonged inflammatory processes. This type of anemia occurs in 27% of cases among other anemias, but it should be noted that the incidence of this anemia in some chronic diseases can reach 100%. The article provides basic information about the leading links in the pathogenesis and treatment of anemia of chronic diseases. The pathogenesis is based on a violation of iron metabolism: the exchange of hepcidin, ferroportin, factors that stimulate the production of hepcidin, inflammatory cytokines. To diagnose this type of anemia, it is necessary to carefully collect anamnesis and search for a long-term chronic illness, assess the state of iron metabolism and the level of transferrin, and it is also necessary to differentiate this type of anemia from iron deficiency. The difference between anemia of chronic disease and iron deficiency is that the latter is characterized by an absolute lack of iron, and it is inaccessible to young erythroid precursors. A significant factor is the determination of the type of iron deficiency after the diagnosis of anemia of chronic disease. The basis of the therapeutic approach to the treatment of anemia of chronic disease is the treatment of the underlying disease. In the case when this is not possible, it is necessary to compensate for the anemia by other methods. Modern medicine offers 4 rational approaches to the treatment of anemia of chronic disease: replacement therapy with blood components; ferrotherapy; the use of erythropoiesis stimulants; targeted cytokine therapy.

The article presents the possible features of the clinical course of paraneoplastic syndrome and its similarity to other diseases, which, considering modern diagnostic accessibility, will reveal the tumor long before its clinical manifestation.

Most cardiovascular diseases (CVD) are of atherosclerotic origin, and lipid disorders play significant role, setting up the cardiovascular continuum, together with other risk factors. It also known that decrease of low density lipoproteins cholesterol (CLDL) level leads to decreased occurrence of CVDs in primary and secondary prevention of the diseases. Statins, at the moment, are a standard of medical care. However, two problems remain on the way to cardiovascular risk reduction — insufficient statins prescription and low rate of archived target levels of cholesterol and CLDL. In the end of October 2017, by the initiative of Sandoz LLC, in Kazan an educational seminar was conducted, where the representatives from 12 regions discussed the issues on statin therapy adherence improvement. Seminar program included lectures, practical interactive events and general discussion. As a specifics of the seminar, the participants not only listened to lectures, but prepared proposals in interactive regimen, discussed them with the colleagues, presented and defended projects. So, every participant was merged into the problem and directly influenced the discussion. Among the participants were internists, cardiologists, neurologists. Seminar vector was directed to revealing and overcoming such barriers for statin adherence as the so­called barriers of consent, understanding and availability, that depend on clinician as well as patient and healthcare system. Also the issues were discussed on the Internet influence on “antistatin” behavior, that prefers “good” bioactive compounds for “vile” statins.

Abstract A preparative procedure is proposed for the synthesis of α-aminophosphonates of natural porphyrins by the microwave-assisted Kabachnik—Fields reaction. [ABSTRACT FROM AUTHOR]

The purpose of the study. To examine the relationship of severity of stenosis of carotid arteries and constitutional types in women with ischemic stroke Materials and methods. Patients evaluated the presence of cardiovascular disease, previous cardiovascular events, type, and subtype of stroke, neurological status was determined according to neurological scales. Anthropometric methods included the determination of constitutional types, different techniques. To assess the presence of atherosclerosis performed color duplex scanning of brachycephalic arteries and laboratory testing (estradiol, hCRP, lipid profile). Results. In the present study in women with ischemic stroke stenosis of carotid artery more than 50 % were found in 13.3 % of cases, less severe stenoses - in 36,0 % of cases. Differences in constitutional characteristics in groups with different severity of stenosis in the carotid arteria identified, although in separate subgroups revealed a weak but statistically significant correlation with certain constitutional types: in the group without stenosis KA - with asthenicmnarrow bone constitutional type (r=0,13) and endomorph constitutional type (r=-0,13); in the group of stenosis KA (to 49 %), asthenic (r=0,13), ectomorphy (r=0,13) and metaplasticity (r=0.14) constitutional types. At the same time, association of the severity of carotid stenosis with laboratory parameters such as the level of estradiol, CRP, the presence of dyslipidemia. Conclusion. In our study there were no differences in constitutional characteristics in groups with different severity of stenosis of the carotid arteries, although in separate subgroups revealed a weak but statistically significant correlation with certain constitutional types. It is advisable to continue the study of the constitutional characteristics, but with other clinical indicators (the relationship of genetic and constitutional factors).