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2. Factors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses.

Author

Bhasin, Shalender, Biggs, Mary, Cawthon, Peggy, Couper, David, Dobs, Adrian, Flicker, Leon, Handelsman, David, Hankey, Graeme, Hannemann, Anke, Haring, Robin, Hsu, Benjumin, Karlsson, Magnus, Martin, Sean, Matsumoto, Alvin, Mellström, Dan, Ohlsson, Claes, ONeill, Terence, Orwoll, Eric, Quartagno, Matteo, Shores, Molly, Steveling, Antje, Tivesten, Åsa, Travison, Thomas, Vanderschueren, Dirk, Wittert, Gary, Wu, Frederick, Yeap, Bu, Marriott, Ross, Murray, Kevin, Adams, Robert, Antonio, Leen, Ballantyne, Christie, and Bauer, Douglas

Subjects
Humans, Male, Adolescent, Young Adult, Adult, Middle Aged, Aged, Sex Hormone-Binding Globulin, Cross-Sectional Studies, Prospective Studies, Gonadal Steroid Hormones, Testosterone, Luteinizing Hormone
Abstract

BACKGROUND: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements. PURPOSE: To clarify factors associated with variations in sex hormone concentrations. DATA SOURCES: Systematic literature searches (to July 2019). STUDY SELECTION: Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry. DATA EXTRACTION: Individual participant data (IPD) (9 studies; n = 21 074) and aggregate data (2 studies; n = 4075). Sociodemographic, lifestyle, and health factors and concentrations of total testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone, and estradiol were extracted. DATA SYNTHESIS: Two-stage random-effects IPD meta-analyses found a nonlinear association of testosterone with age, with negligible change among men aged 17 to 70 years (change per SD increase about the midpoint, -0.27 nmol/L [-7.8 ng/dL] [CI, -0.71 to 0.18 nmol/L {-20.5 to 5.2 ng/dL}]) and decreasing testosterone levels with age for men older than 70 years (-1.55 nmol/L [-44.7 ng/dL] [CI, -2.05 to -1.06 nmol/L {-59.1 to -30.6 ng/dL}]). Testosterone was inversely associated with body mass index (BMI) (change per SD increase, -2.42 nmol/L [-69.7 ng/dL] [CI, -2.70 to -2.13 nmol/L {-77.8 to -61.4 ng/dL}]). Testosterone concentrations were lower for men who were married (mean difference, -0.57 nmol/L [-16.4 ng/dL] [CI, -0.89 to -0.26 nmol/L {-25.6 to -7.5 ng/dL}]); undertook at most 75 minutes of vigorous physical activity per week (-0.51 nmol/L [-14.7 ng/dL] [CI, -0.90 to -0.13 nmol/L {-25.9 to -3.7 ng/dL}]); were former smokers (-0.34 nmol/L [-9.8 ng/dL] [CI, -0.55 to -0.12 nmol/L {-15.9 to -3.5 ng/dL}]); or had hypertension (-0.53 nmol/L [-15.3 ng/dL] [CI, -0.82 to -0.24 nmol/L {-23.6 to -6.9 ng/dL}]), cardiovascular disease (-0.35 nmol/L [-10.1 ng/dL] [CI, -0.55 to -0.15 nmol/L {-15.9 to -4.3 ng/dL}]), cancer (-1.39 nmol/L [-40.1 ng/dL] [CI, -1.79 to -0.99 nmol/L {-51.6 to -28.5 ng/dL}]), or diabetes (-1.43 nmol/L [-41.2 ng/dL] [CI, -1.65 to -1.22 nmol/L {-47.6 to -35.2 ng/dL}]). Sex hormone-binding globulin was directly associated with age and inversely associated with BMI. Luteinizing hormone was directly associated with age in men older than 70 years. LIMITATION: Cross-sectional analysis, heterogeneity between studies and in timing of blood sampling, and imputation for missing data. CONCLUSION: Multiple factors are associated with variation in male testosterone, SHBG, and LH concentrations. Reduced testosterone and increased LH concentrations may indicate impaired testicular function after age 70 years. Interpretation of individual testosterone measurements should account particularly for age older than 70 years, obesity, diabetes, and cancer. PRIMARY FUNDING SOURCE: Medical Research Future Fund, Government of Western Australia, and Lawley Pharmaceuticals. (PROSPERO: CRD42019139668).

Published
2023

5. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Author

Phelps, Nowell H, Singleton, Rosie K, Zhou, Bin, Heap, Rachel A, Mishra, Anu, Bennett, James E, Paciorek, Christopher J, Lhoste, Victor PF, Carrillo-Larco, Rodrigo M, Stevens, Gretchen A, Rodriguez-Martinez, Andrea, Bixby, Honor, Bentham, James, Di Cesare, Mariachiara, Danaei, Goodarz, Rayner, Archie W, Barradas-Pires, Ana, Cowan, Melanie J, Savin, Stefan, Riley, Leanne M, Aguilar-Salinas, Carlos A, Baker, Jennifer L, Barkat, Amina, Bhutta, Zulfiqar A, Branca, Francesco, Caixeta, Roberta B, Cuschieri, Sarah, Farzadfar, Farshad, Ganapathy, Shubash, Ikeda, Nayu, Iotova, Violeta, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Lin, Hsien-Ho, Ma, Jun, Mbanya, Jean Claude N, Miranda, J Jaime, Pradeepa, Rajendra, Rodríguez-Artalejo, Fernando, Sorić, Maroje, Turley, Maria, Wang, Limin, Webster-Kerr, Karen, Aarestrup, Julie, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdeen, Ziad A, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Abubakar Garba, Jamila, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J, Adu-Afarwuah, Seth, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Ågren, Åsa, Aguenaou, Hassan, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lahou, Badreya, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Al Qaoud, Nawal M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A, Alexius, Sylvia, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkerwi, Ala'a, Alkhatib, Buthaina M, Allin, Kristine, Alomary, Shaker A, Alomirah, Husam F, Alshangiti, Arwa M, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assefa, Nega, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Aung, May Soe, Aurélio de Valois, Correia Júnior Marco, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Babu, Bontha V, Bacopoulou, Flora, Bæksgaard Jørgensen, Maja, Baharudin, Azli, Bahijri, Suhad, Bajramovic, Izet, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R, Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz, Bata, Iqbal, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berhane, Yemane, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Berrios Carrasola, Ximena, Bettiol, Heloísa, Beutel, Manfred E, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Biasch, Katia, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Anne A, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Blychfeld Magnazu, Moran, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boer, Jolanda MA, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Botomba, Steve, Bourne, Rupert RA, Bovet, Pascal, Boymatova, Khadichamo, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Braithwaite, Tasanee, Brajkovich, Imperia, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brophy, Sinead, Brug, Johannes, Bruno, Graziella, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de León, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, José, Can, Günay, Cândido, Ana Paula c, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajús, José A, Casanueva, Felipe F, Casas, Maribel, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Angelique, Chan, Queenie, Charchar, Fadi J, Charles, Marie-Aline, Chaturvedi, Himanshu K, Chaturvedi, Nish, Che Abdul Rahim, Norsyamlina, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Cojocaru, Cosmin R, Colorado-Yohar, Sandra, Compañ-Gabucio, Laura-María, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Cortés, Lilia Yadira, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Csányi, Tamás, Csilla, Semánová, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva, Alanna G, Dacica, Liliana, Dahm, Christina C, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Backer, Guy, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, De Neve, Jan-Walter, Duarte de Oliveira, Paula, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, de Sá, Ana Carolina MGN, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent Jr, Delisle, Hélène, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Dereń, Katarzyna, Deschamps, Valérie, Devrishov, Ruslan D, Dhimal, Meghnath, Di Castelnuovo, Augusto, Dias-da-Costa, Juvenal Soares, Díaz-Sánchez, María Elena, Diaz, Alejandro, Díaz Fernández, Pedro, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Dong, Yanhui, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Dörr, Marcus, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duleva, Vesselka L, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dwyer, Terence, Dyussupova, Azhar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ammari, Laila, El Ati, Jalila, Eldemire-Shearer, Denise, Elliott, Paul, Enang, Ofem, Endevelt, Ronit, Engle-Stone, Reina, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Evans, Roger G, Faeh, David, Fagherazzi, Guy, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farrugia Sant'Angelo, Victoria, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Fawzi, Wafaie W, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Gerson, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferreira, Haroldo S, Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Fras, Zlatko, Fraser, Brooklyn, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Gafencu, Mihai, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Gao, Pei, Garcia-de-la-Hera, Manoli, García Mérida, María José, García Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, George, Ronnie, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gieger, Christian, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Gogen, Sibel, Goldberg, Marcel, Goltzman, David, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Leon, Margot, González-Rivas, Juan P, González-Villalpando, Clicerio, González-Villalpando, María-Elena, Gonzalez, Angel R, Gottrand, Frederic, Graça, Antonio Pedro, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregg, Edward W, Gregor, Ronald D, Gregório, Maria João, Grøholt, Else Karin, Grøntved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Guajardo, Viviana, Gualdi-Russo, Emanuela, Guallar-Castillón, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerchet, Maëlenn, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gujral, Unjali P, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc J, Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurinović, Mirjana A, Gutiérrez González, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Gwee, Xinyi, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hanekom, Willem A, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hardy, Louise, Hari Kumar, Rachakulla, Harmer Lassen, Tina, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felső, Regina, Heier, Margit, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera-Cuenca, Marianella, Herrera, Victor M, Herter-Aeberli, Isabelle, Herzig, Karl-Heinz, Heshmat, Ramin, Heude, Barbara, Hill, Allan G, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Höfelmann, Doroteia A, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hoogendijk, Emiel, Hopman, Wilma M, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Huidumac Petrescu, Constanta, Husseini, Abdullatif, Huu, Chinh Nguyen, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Iakupova, Ellina M, Ibarluzea, Jesús, Ibrahim, Mohsen M, Ibrahim Wong, Norazizah, Igland, Jannicke, Ijoma, Chinwuba, Ikram, M Arfan, Iñiguez, Carmen, Irazola, Vilma E, Ishida, Takafumi, Isiguzo, Godsent C, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ittermann, Till, Ivanova-Pandourska, Ivaila Y, Iwasaki, Masanori, Jääskeläinen, Tuija, Jackson, Rod T, Jacobs, Jeremy M, Jadoul, Michel, Jafar, Tazeen, Jallow, Bakary, James, Kenneth, Jamil, Kazi M, Jamrozik, Konrad, Jan, Nataša, Jansson, Anna, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarnig, Gerald, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jennings, Garry, Jiang, Chao Qiang, Jimenez, Ramon O, Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Jonnagaddala, Jitendra, Jøran Kjerpeseth, Lars, Jørgensen, Torben, Joshi, Pradeep, Joshi, Rohina, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J, Judge, Debra S, Juolevi, Anne, Jurak, Gregor, Jurca Simina, Iulia, Juresa, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kadvan, Agnes L, Kafatos, Anthony, Kaj, Mónika, Kajantie, Eero O, Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kameli, Yves, Kanala, Kodanda R, Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Kårhus, Line L, Karki, Khem B, Karlsson, Omat, Kassi Anicet, Adoubi, Katchunga, Philippe B, Katibeh, Marzieh, Katz, Joanne, Katzmarzyk, Peter T, Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli M, Kaze, François F, Kazembe, Benson M, Ke, Calvin, Keil, Ulrich, Keinan Boker, Lital, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han CG, Keramati, Maryam, Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khaledifar, Arsalan, Khalili, Davood, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Khouw, Ilse MSL, Kiechl-Kohlendorfer, Ursula, Kiechl, Sophia J, Kiechl, Stefan, Killewo, Japhet, Kim, Hyeon Chang, Kim, Jeongseon, Kindblom, Jenny M, Kingston, Andrew, Klakk, Heidi, Klanarong, Suntara, Klanova, Jana, Klimek, Magdalena, Klimont, Jeannette, Klumbiene, Jurate, Knoflach, Michael, Kobel, Susanne, Koirala, Bhawesh, Kolle, Elin, Kolo, Sanda M, Kolsteren, Patrick, König, Jürgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Kouda, Katsuyasu, Koussoh Simone, Malik, Kovács, Éva, Kovacs, Viktoria Anna, Kovalskys, Irina, Kowlessur, Sudhir, Koziel, Slawomir, Kratenova, Jana, Kratzer, Wolfgang, Kriaucioniene, Vilma, Kriemler, Susi, Kristensen, Peter Lund, Krizan, Helena, Kroker-Lobos, Maria F, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S, Kruger, Ruan, Kryst, Łukasz, Kubinova, Ruzena, Kuciene, Renata, Kujala, Urho M, Kujundzic, Enisa, Kulaga, Zbigniew, Kulimbet, Mukhtar, Kulothungan, Vaitheeswaran, Kumar, R Krishna, Kumari, Meena, Kunešová, Marie, Kurjata, Pawel, Kusuma, Yadlapalli S, Kutsenko, Vladimir, Kuulasmaa, Kari, Kyobutungi, Catherine, La, Quang Ngoc, Laamiri, Fatima Zahra, Laatikainen, Tiina, Labadarios, Demetre, Lachat, Carl, Lackner, Karl J, Lai, Daphne, Laid, Youcef, Lall, Lachmie, Lam, Tai Hing, Landaeta Jimenez, Maritza, Landais, Edwige, Lankila, Tiina, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Larissa, Simo Pone, Lateva, Mina P, Latt, Tint Swe, Laurenzi, Martino, Lauria, Laura, Lazo-Porras, Maria, Le Coroller, Gwenaëlle, 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Alireza, Safarpour, Ali Reza, Safi, Sare, Safiri, Saeid, Saghi, Mohammad Hossien, Saidi, Olfa, Saieva, Calogero, Sakata, Satoko, Saki, Nader, Šalaj, Sanja, Salanave, Benoit, Salazar Martinez, Eduardo, Salhanova, Akkumis, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Samoutian, Margarita, Sánchez-Abanto, Jose, Sánchez Rodríguez, Inés, Sandjaja, Sans, Susana, Santa-Marina, Loreto, Santacruz, Ethel, Santos, Diana A, Santos, Ina S, Santos, Lèlita C, Santos, Maria Paula, Santos, Osvaldo, Santos, Rute, Santos, Tamara R, Saramies, Jouko L, Sardinha, Luis B, Sarrafzadegan, Nizal, Sathish, Thirunavukkarasu, Saum, Kai-Uwe, Savva, Savvas, Savy, Mathilde, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Schaffrath Rosario, Angelika, Schargrodsky, Herman, Schienkiewitz, Anja, Schindler, Karin, Schipf, Sabine, Schmidt, Börge, Schmidt, Carsten O, Schmidt, Ida Maria, Schneider, Andrea, Schnohr, Peter, Schöttker, Ben, Schramm, Sara, Schramm, Stine, Schröder, Helmut, Schultsz, Constance, Schultz, Gry, Schulze, Matthias B, Schutte, Aletta E, Sebert, Sylvain, Sedaghattalab, Moslem, Selamat, Rusidah, Sember, Vedrana, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Sequera, Guillermo, Serra-Majem, Luis, Servais, Jennifer, Ševčíková, Ľudmila, Sewpaul, Ronel, Shalnova, Svetlana, Shamah-Levy, Teresa, Shamshirgaran, Seyed Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K, Sharman, Almaz, Shaw, Jonathan E, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shimony, Tal, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M, Sidossis, Labros S, Silitrari, Natalia, Silva, Antonio M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Silva, Kelly Samara, Sim, Xueling, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöberg, Agneta, Sjöström, Michael, Skoblina, Elena V, Skoblina, Natalia A, Slazhnyova, Tatyana, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Söderberg, Stefan, Soekatri, Moesijanti YE, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Solovieva, Yuliya V, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Soofi, Sajid, Sørensen, Thorkild IA, Sørgjerd, Elin P, Sossa Jérome, Charles, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sousa-Poza, Alfonso, Sovic, Slavica, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Spencer, Phoebe R, Spinelli, Angela, Spiroski, Igor, Staessen, Jan A, Stamm, Hanspeter, Stang, Andreas, Starc, Gregor, Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Steinsbekk, Silje, Stergiou, George S, Stessman, Jochanan, Stevanović, Ranko, Stieber, Jutta, Stöckl, Doris, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Sturua, Lela, Suárez-Medina, Ramón, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Sugiyama, Mindy, Suka, Machi, Sulo, Gerhard, Sun, Chien-An, Sun, Liang, Sund, Malin, Sundström, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Sweis, Nabil William G, Swinburn, Boyd A, Sy, Rody G, Sylva, René Charles, Szponar, Lucjan, Tabone, Lorraine, Tai, E Shyong, Takuro, Furusawa, Tambalis, Konstantinos D, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanrygulyyeva, Maya, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Taxová Braunerová, Radka, Taylor, Anne, Taylor, Julie, Tchibindat, Félicité, Te Velde, Saskia, Tebar, William R, Tell, Grethe S, Tello, Tania, Tessema, Masresha, Tham, Yih Chung, Thankappan, KR, Theobald, Holger, Theodoridis, Xenophon, Thomas, Nihal, Thorand, Barbara, Thrift, Amanda G, Tichá, Ľubica, Timmermans, Erik J, Tjandrarini, Dwi Hapsari, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Tomaszewski, Maciej, Topbas, Murat, Topór-Mądry, Roman, Torheim, Liv Elin, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Tremblay, Mark S, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsintavis, Panagiotis, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Twig, Gilad, Tynelius, Per, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Udoji, Nwannedimma, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Varona-Pérez, Patricia, Vasan, Senthil K, Vasques, Daniel G, Vatasescu, Radu, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Viriyautsahakul, Napaphan, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Vourli, Georgia, Voutilainen, Ari, Vrijheid, Martine, Vrijkotte, Tanja GM, Vuletić, Silvije, Wade, Alisha N, Waldhör, Thomas, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid

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2024
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7. Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor – substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial

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David, Karel, Devos, Gaëtan, Narinx, Nick, Antonio, Leen, Devlies, Wout, Deboel, Ludo, Schollaert, Dieter, Eisenhauer, Anton, Cavalier, Etienne, Vanderschueren, Dirk, Claessens, Frank, Joniau, Steven, and Decallonne, Brigitte

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2023
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11. Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold

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Anand-Ivell, Ravinder, primary, Heng, Kee, additional, Antonio, Leen, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe F., additional, Maggi, Mario, additional, O’Neill, Terence W., additional, Punab, Margus, additional, Rastrelli, Giulia, additional, Slowikowska-Hilczer, Jolanta, additional, Tournoy, Jos, additional, Vanderschueren, Dirk, additional, Wu, Frederick CW., additional, Huhtaniemi, Ilpo T., additional, and Ivell, Richard, additional

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2024
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12. Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients

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De Smedt, Julie, primary, Aura, Claudia, additional, Van Kelst, Sofie, additional, Janssen, Laudine, additional, Marasigan, Vivien, additional, Boecxstaens, Veerle, additional, Stas, Marguerite, additional, Bogaerts, Kris, additional, Belmans, Ann, additional, Cleynen, Isabelle, additional, Vanderschueren, Dirk, additional, Vandenberghe, Katleen, additional, Bechter, Oliver, additional, Nikkels, Arjen, additional, Strobbe, Tinne, additional, Emri, Gabriella, additional, Lambrechts, Dieter, additional, and Garmyn, Marjan, additional

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2024
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13. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Author

Zhou, Bin, Carrillo-Larco, Rodrigo M, Danaei, Goodarz, Riley, Leanne M, Paciorek, Christopher J, Stevens, Gretchen A, Gregg, Edward W, Bennett, James E, Solomon, Bethlehem, Singleton, Rosie K, Sophiea, Marisa K, Iurilli, Maria LC, Lhoste, Victor PF, Cowan, Melanie J, Savin, Stefan, Woodward, Mark, Balanova, Yulia, Cifkova, Renata, Damasceno, Albertino, Elliott, Paul, Farzadfar, Farshad, He, Jiang, Ikeda, Nayu, Kengne, Andre P, Khang, Young-Ho, Kim, Hyeon Chang, Laxmaiah, Avula, Lin, Hsien-Ho, Margozzini Maira, Paula, Miranda, J Jaime, Neuhauser, Hannelore, Sundström, Johan, Varghese, Cherian, Widyahening, Indah S, Zdrojewski, Tomasz, Abarca-Gómez, Leandra, Abdeen, Ziad A, Abdul Rahim, Hanan F, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Adams, Robert J, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A, Agyemang, Charles, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmadizar, Fariba, Ahmed, Soheir H, Ahrens, Wolfgang, Ajlouni, Kamel, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Aly, Eman, Amarapurkar, Deepak N, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Ansong, Daniel, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assunção, Maria Cecília F, Auvinen, Juha, Avdićová, Mária, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V, Bahijri, Suhad, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Banadinović, Maja, Bandosz, Piotr, Banegas, José R, Baran, Joanna, Barbagallo, Carlo M, Barceló, Alberto, Barkat, Amina, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz D, Bata, Iqbal, Batieha, Anwar M, Batyrbek, Assembekov, Baur, Louise A, Beaglehole, Robert, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benet, Mikhail, Benson, Lowell S, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloísa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bhargava, Santosh K, Bia, Daniel, Biasch, Katia, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boeing, Heiner, Boggia, Jose G, Boissonnet, Carlos P, Bojesen, Stig E, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Bovet, Pascal, Boyer, Christopher B, Braeckman, Lutgart, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Brenner, Hermann, Brewster, Lizzy M, Briceño, Yajaira, Brito, Miguel, Bruno, Graziella, Bueno-de-Mesquita, H Bas, Bueno, Gloria, Bugge, Anna, Burns, Con, Bursztyn, Michael, Cabrera de León, Antonio, 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Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elosua, Roberto, Erasmus, Rajiv T, Erbel, Raimund, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Felix, Stephan B, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferreira, Haroldo S, Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fink, Günther, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Frikke-Schmidt, Ruth, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujita, Yuki, Fumihiko, Matsuda, Furdela, Viktoriya, Furer, Ariel, 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D, Grodzicki, Tomasz, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Guan, Ong Peng, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc J, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Ha, Seongjun, Hadaegh, Farzad, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hari Kumar, Rachakulla, Hashemi-Shahri, Seyed Mohammad, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Yuna, Heier, Margit, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herqutanto, Herrala, Sauli, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Holdsworth, Michelle, Homayounfar, Reza, Horasan Dinc, Gonul, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, 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Ben, Schramm, Sara, Schultsz, Constance, Schutte, Aletta E, Sebert, Sylvain, Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Servais, Jennifer, Shalnova, Svetlana A, Shamah-Levy, Teresa, Shamshirgaran, Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K, Shaw, Jonathan E, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shin, Dong Wook, Shirani, Majid, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöström, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobngwi, Eugène, Söderberg, Stefan, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Sørensen, Thorkild IA, Sørgjerd, Elin P, Sorić, Maroje, Sossa Jérome, Charles, Soumaré, Aïcha, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Staessen, Jan A, Starc, Gregor, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stessman, Jochanan, Stieber, Jutta, Stöckl, Doris, Stocks, Tanja, Stokwiszewski, Jakub, Stronks, Karien, Strufaldi, Maria Wany, Suka, Machi, Sun, Chien-An, Sung, Yn-Tz, Suriyawongpaisal, Paibul, Sy, Rody G, Syddall, Holly E, Sylva, René Charles, Szklo, Moyses, Tai, E Shyong, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarqui-Mamani, Carolina B, Taylor, Anne, Taylor, Julie, Tebar, William R, Tell, Grethe S, Tello, Tania, Tham, Yih Chung, Thankappan, KR, Theobald, Holger, Theodoridis, Xenophon, Thijs, Lutgarde, Thinggaard, Mikael, Thomas, Nihal, Thorand, Barbara, Thuesen, Betina H, Timmermans, Erik J, Tjandrarini, Dwi H, Tjonneland, Anne, Toft, Ulla, Tolonen, Hanna K, Tolstrup, Janne S, Topbas, Murat, Topór-Madry, Roman, Tormo, María José, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Touloumi, Giota, Traissac, Pierre, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsugane, Shoichiro, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L, Twig, Gilad, Tynelius, Per, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ulmer, Hanno, Uusitalo, Hannu MT, Valdivia, Gonzalo, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, van Zutphen, Elisabeth M, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Vasan, Senthil K, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Verschuren, WM Monique, Verstraeten, Roosmarijn, Victora, Cesar G, Viet, Lucie, Villalpando, Salvador, Vineis, Paolo, Vioque, Jesus, Virtanen, Jyrki K, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vlasoff, Tiina, Vollenweider, Peter, Voutilainen, Ari, Wade, Alisha N, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wei, Wenbin, Weres, Aneta, Werner, Bo, Whincup, Peter H, Widhalm, Kurt, Wiecek, Andrzej, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Emmanuel A, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Andrew, Wong, Tien Yin, Woo, Jean, Wu, Frederick C, Wu, Shouling, Wyszynska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yasuharu, Tabara, Ye, Xingwang, Yiallouros, Panayiotis K, Yoosefi, Moein, Yoshihara, Akihiro, You, San-Lin, Younger-Coleman, Novie O, Yusoff, Ahmad Faudzi, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zapata, Maria Elisa, Zaw, Ko Ko, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhen, Shiqi, Zheng, Yingfeng, Zholdin, Bekbolat, Zhu, Dan, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, and Ezzati, Majid

Published
2021
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17. THU652 Associations Of Testosterone, Dihydrotestosterone, Estradiol And Sex Hormone-binding Globulin With All-cause And Cardiovascular Mortality, And Incident Cardiovascular Events In Men: Individual Participant Data Meta-analyses

Author

Yeap, Bu Beng, primary, Marriott, Ross J, additional, Antonio, Leen, additional, Bhasin, Shalender, additional, Dobs, Adrian S, additional, Handelsman, David J, additional, Hankey, Graeme J, additional, Haring, Robin, additional, Matsumoto, Alvin M, additional, Ohlsson, Claes, additional, Orwoll, Eric S, additional, Vanderschueren, Dirk M, additional, Wittert, Gary Allen, additional, Wu, Frederick C, additional, and Murray, Kevin, additional

Published
2023
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19. OR25-04 Factors Affecting Testosterone Concentrations In Men: Individual Participant Data Meta-analyses From The Androgens In Men Study

Author

Marriott, Ross J, primary, Murray, Kevin, additional, Antonio, Leen, additional, Bhasin, Shalender, additional, Sandra Dobs, Adrian, additional, Handelsman, David J, additional, Hankey, Graeme J, additional, Haring, Robin, additional, Matsumoto, Alvin M, additional, Ohlsson, Claes, additional, Orwoll, Eric S, additional, Vanderschueren, Dirk M, additional, Allen Wittert, Gary, additional, Wu, Frederick C, additional, and Beng Yeap, Bu, additional

Published
2023
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20. Testosterone Restores Body Composition, Bone Mass, and Bone Strength Following Early Puberty Suppression in a Mouse Model Mimicking the Clinical Strategy in Trans Boys

Author

Dubois, Vanessa, primary, Ciancia, Silvia, additional, Doms, Stefanie, additional, El Kharraz, Sarah, additional, Sommers, Vera, additional, Kim, Na Ri, additional, David, Karel, additional, Van Dijck, Jolien, additional, Valle-Tenney, Roger, additional, Maes, Christa, additional, Antonio, Leen, additional, Decallonne, Brigitte, additional, Carmeliet, Geert, additional, Claessens, Frank, additional, Cools, Martine, additional, and Vanderschueren, Dirk, additional

Published
2023
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21. List of contributors

Author

Abrahamsen, Bo, primary, Adler, Robert A., additional, Ajjour, Sara, additional, Alemi, Mohammad Mehdi, additional, Anderson, Dennis E., additional, Arnett, Timothy R., additional, Assaad, Mariam A., additional, Ballane, Ghada T., additional, Baron, Roland, additional, Bassett, J.H. Duncan, additional, Bauer, Douglas C., additional, Bauman, William A., additional, Beavers, Kristen M., additional, Berry, Sarah D., additional, Bilezikian, John P., additional, Biver, Emmanuel, additional, Bliuc, Dana, additional, Bonewald, Lynda F., additional, Boskey, Adele L., additional, Bouxsein, Mary L., additional, Bravenboer, Nathalie, additional, Brown, Todd T., additional, Bukata, Susan V., additional, Burkhart, Katelyn, additional, Canalis, Ernesto, additional, Cardozo, Christopher, additional, Castillo, Alesha B., additional, Cauley, Jane A., additional, Center, Jacqueline R., additional, Chen, Julia C., additional, Civitelli, Roberto, additional, Cohen, Adi, additional, Cosman, Felicia, additional, Crandall, Carolyn J., additional, Crawford, Brooke M., additional, Cusano, Natalie E., additional, de Paula, Francisco J.A., additional, Delbaere, Kim, additional, Dempster, David W., additional, Diab, Dima L., additional, Dick-de-Paula, Ingrid, additional, DiMeglio, Linda A., additional, Drake, Matthew T., additional, Dubrovsky, Alanna M.K., additional, D’Onofrio, Luca, additional, Eastell, Richard, additional, Elder, Grahame J., additional, El-Hajj Fuleihan, Ghada A., additional, Ensrud, Kristine E., additional, Ferrari, Serge, additional, Freudenthal, Bernard, additional, Genant, Harry K., additional, Gerstenfeld, Louis C., additional, Giangregorio, Lora, additional, Gielen, Evelien, additional, Gold, Deborah T., additional, Goldring, Steven R., additional, Gordon, Catherine M., additional, Gori, Francesca, additional, Greendale, Gail A., additional, Griffith, James F., additional, Hadji, Peyman, additional, Hernandez, Christopher J., additional, Hoggatt, Jonathan, additional, Houston, Denise K., additional, Hussein, Amira I., additional, Jacobs, Christopher R., additional, Jiang, Xuezhi, additional, Johnston, James D., additional, Kagan, Risa, additional, Karim, Lamya, additional, Karvonen-Gutierrez, Carrie, additional, Katzman, Wendy B., additional, Kawai, Masanobu, additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Kontulainen, Saija A., additional, Kostenuik, Paul, additional, Krez, Alexandra, additional, Kronenberg, Henry, additional, Kumar, Rajiv, additional, Lane, Nancy E., additional, Langsetmo, Lisa, additional, Laurent, Michaël R., additional, Lawenius, L., additional, Leikin, Sergey, additional, Leslie, William D., additional, Lewiecki, E. Michael, additional, Liu, Minghao, additional, Liu, Yi, additional, Lord, Stephen R., additional, Lorenzo, Joseph, additional, Ma, Nina S., additional, Maalouf, Naim M., additional, Marcus, Robert, additional, McClung, Michael R., additional, Mendes, Marcela Moraes, additional, Miller, Paul D., additional, Misra, Madhusmita, additional, Mohseni, Mahshid, additional, Morgan, Elise F., additional, Morin, Suzanne N., additional, Mukaddam, Mona Al, additional, Mulder, Chris J.J., additional, Nair, Nandini, additional, Napoli, Nicola, additional, Nasomyont, Nat, additional, Nelson, Dorothy A., additional, Nieves, Jeri W., additional, Nissenson, Robert, additional, Ohlsson, Claes, additional, Oleson, Christina V., additional, Ortinau, Laura, additional, Orwoll, Eric, additional, Ott, Susan M., additional, Pacifici, Roberto, additional, Palermo, Andrea, additional, Parfitt, A.M., additional, Park, Dongsu, additional, Provot, Sylvain, additional, Randhawa, Sonia Bhandari, additional, Randolph, John F., additional, Rivadeneira, Fernando, additional, Robey, Pamela Gehron, additional, Robinson, Lauren, additional, Rogers-Soeder, Tara, additional, Roodman, G. David, additional, Rosen, Clifford J., additional, Saag, Kenneth G., additional, Sahni, Shivani, additional, Sakhaee, Khashayar, additional, Scadden, David T., additional, Schafer, Anne L., additional, Schipani, Ernestina, additional, Serra, Monica C., additional, Shapiro, Jay R., additional, Sherrington, Catherine, additional, Shikany, James M., additional, Silverberg, Shonni J., additional, Singer, Andrea J., additional, Sjögren, K., additional, Snyder, Peter J., additional, Stein, Emily M., additional, Swanson, Christine M., additional, Szulc, Pawel, additional, Taxel, Pamela, additional, Tebben, Peter J., additional, Twardowski, Sarah E., additional, Uitterlinden, André G., additional, Vaidya, Rachana, additional, Vallera, Cristianna, additional, van Bodegraven, Adriaan A., additional, van der Eerden, Bram C.J., additional, van der Meulen, Marjolein C.H., additional, van Wijnen, André J., additional, Vanderschueren, Dirk, additional, Wactawski-Wende, Jean, additional, Watts, Laura, additional, Watts, Nelson B., additional, Weaver, Ashley A., additional, Weinstein, Robert S., additional, Williams, Graham R., additional, Wu, Joy, additional, Wu, Karin C., additional, Yin, Michael T., additional, Yu, Elaine W., additional, and Zhou, Hua, additional

Published
2021
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23. Associations of 25‐Hydroxyvitamin D and 1,25‐Dihydroxyvitamin D With Bone Mineral Density, Bone Mineral Density Change, and Incident Nonvertebral Fracture

Author

Swanson, Christine M, Srikanth, Priya, Lee, Christine G, Cummings, Steven R, Jans, Ivo, Cauley, Jane A, Bouillon, Roger, Vanderschueren, Dirk, Orwoll, Eric S, Nielson, Carrie M, and Group, for the Osteoporotic Fractures in Men MrOS Study Research

Subjects
Physical Injury - Accidents and Adverse Effects, Aging, Prevention, Nutrition, Osteoporosis, Musculoskeletal, Aged, Aged, 80 and over, Bone Density, Follow-Up Studies, Hip Fractures, Humans, Incidence, Male, Radiography, Risk Factors, Vitamin D, Osteoporotic Fractures in Men MrOS Study Research Group, 1, 25-DIHYDROXYVITAMIN D, 25-HYDROXYVITAMIN D, BONE MINERAL DENSITY, CALCITRIOL, FRACTURE, Biological Sciences, Engineering, Medical and Health Sciences, Anatomy & Morphology
Abstract

Relationships between 1,25-dihydroxyvitamin D (1,25(OH)2 D) and skeletal outcomes are uncertain. We examined the associations of 1,25(OH)2 D with bone mineral density (BMD), BMD change, and incident non-vertebral fractures in a cohort of older men and compared them with those of 25-hydroxyvitamin D (25OHD). The study population included 1000 men (aged 74.6 ± 6.2 years) in the Osteoporotic Fractures in Men (MrOS) study, of which 537 men had longitudinal dual-energy X-ray absorptiometry (DXA) data (4.5 years of follow-up). A case-cohort design and Cox proportional hazards models were used to test the association between vitamin D metabolite levels and incident nonvertebral and hip fractures. Linear regression models were used to estimate the association between vitamin D measures and baseline BMD and BMD change. Interactions between 25OHD and 1,25(OH)2 D were tested for each outcome. Over an average follow-up of 5.1 years, 432 men experienced incident nonvertebral fractures, including 81 hip fractures. Higher 25OHD was associated with higher baseline BMD, slower BMD loss, and lower hip fracture risk. Conversely, men with higher 1,25(OH)2 D had lower baseline BMD. 1,25(OH)2 D was not associated with BMD loss or nonvertebral fracture. Compared with higher levels of calcitriol, the risk of hip fracture was higher in men with the lowest 1,25(OH)2 D levels (8.70 to 51.60 pg/mL) after adjustment for baseline hip BMD (hazard ratio [HR] = 1.99, 95% confidence interval [CI] 1.19-3.33). Adjustment of 1,25(OH)2 D data for 25OHD (and vice versa) had little effect on the associations observed but did attenuate the hip fracture association of both vitamin D metabolites. In older men, higher 1,25(OH)2 D was associated with lower baseline BMD but was not related to the rate of bone loss or nonvertebral fracture risk. However, with BMD adjustment, a protective association for hip fracture was found with higher 1,25(OH)2 D. The associations of 25OHD with skeletal outcomes were generally stronger than those for 1,25(OH)2 D. These results do not support the hypothesis that measures of 1,25(OH)2 D improve the ability to predict adverse skeletal outcomes when 25OHD measures are available. © 2015 American Society for Bone and Mineral Research.

Published
2015

24. Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.

Author

Moayyeri, Alireza, Hsu, Yi-Hsiang, Karasik, David, Estrada, Karol, Xiao, Su-Mei, Nielson, Carrie, Srikanth, Priya, Giroux, Sylvie, Wilson, Scott G, Zheng, Hou-Feng, Smith, Albert V, Pye, Stephen R, Leo, Paul J, Teumer, Alexander, Hwang, Joo-Yeon, Ohlsson, Claes, McGuigan, Fiona, Minster, Ryan L, Hayward, Caroline, Olmos, José M, Lyytikäinen, Leo-Pekka, Lewis, Joshua R, Swart, Karin MA, Masi, Laura, Oldmeadow, Chris, Holliday, Elizabeth G, Cheng, Sulin, van Schoor, Natasja M, Harvey, Nicholas C, Kruk, Marcin, del Greco M, Fabiola, Igl, Wilmar, Trummer, Olivia, Grigoriou, Efi, Luben, Robert, Liu, Ching-Ti, Zhou, Yanhua, Oei, Ling, Medina-Gomez, Carolina, Zmuda, Joseph, Tranah, Greg, Brown, Suzanne J, Williams, Frances M, Soranzo, Nicole, Jakobsdottir, Johanna, Siggeirsdottir, Kristin, Holliday, Kate L, Hannemann, Anke, Go, Min Jin, Garcia, Melissa, Polasek, Ozren, Laaksonen, Marika, Zhu, Kun, Enneman, Anke W, McEvoy, Mark, Peel, Roseanne, Sham, Pak Chung, Jaworski, Maciej, Johansson, Åsa, Hicks, Andrew A, Pludowski, Pawel, Scott, Rodney, Dhonukshe-Rutten, Rosalie AM, van der Velde, Nathalie, Kähönen, Mika, Viikari, Jorma S, Sievänen, Harri, Raitakari, Olli T, González-Macías, Jesús, Hernández, Jose L, Mellström, Dan, Ljunggren, Osten, Cho, Yoon Shin, Völker, Uwe, Nauck, Matthias, Homuth, Georg, Völzke, Henry, Haring, Robin, Brown, Matthew A, McCloskey, Eugene, Nicholson, Geoffrey C, Eastell, Richard, Eisman, John A, Jones, Graeme, Reid, Ian R, Dennison, Elaine M, Wark, John, Boonen, Steven, Vanderschueren, Dirk, Wu, Frederick CW, Aspelund, Thor, Richards, J Brent, Bauer, Doug, Hofman, Albert, Khaw, Kay-Tee, Dedoussis, George, Obermayer-Pietsch, Barbara, Gyllensten, Ulf, Pramstaller, Peter P, and Lorenc, Roman S

Subjects
Calcaneus, Humans, Osteoporosis, Genetic Predisposition to Disease, Ultrasonography, Cohort Studies, Bone Density, Polymorphism, Single Nucleotide, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Fractures, Bone, Genome-Wide Association Study, Young Adult, Human Genome, Genetics, Aging, 2.1 Biological and endogenous factors, Aetiology, Musculoskeletal, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.

Published
2014

25. Number of CAG repeats and mortality in middle aged and older men

Author

Heald, Adrian, primary, Cook, Michael J., additional, Antonio, Leen, additional, Tournoy, Jos, additional, Ghaffari, Parisa, additional, Mannan, Fahmida, additional, Fachim, Helene, additional, Vanderschueren, Dirk, additional, Laing, Ian, additional, Hackett, Geoff, additional, Casanueva, Felipe F., additional, Huhtaniemi, Ilpo T., additional, Maggi, Mario, additional, Rastrelli, Giulia, additional, Slowikowska‐Hilczer, Jolanta, additional, Wu, Fred, additional, and O'Neill, Terence W., additional

Published
2023
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26. Factors Associated With Circulating Sex Hormones in Men

Author

Marriott, Ross J., primary, Murray, Kevin, additional, Adams, Robert J., additional, Antonio, Leen, additional, Ballantyne, Christie M., additional, Bauer, Douglas C., additional, Bhasin, Shalender, additional, Biggs, Mary L., additional, Cawthon, Peggy M., additional, Couper, David J., additional, Dobs, Adrian S., additional, Flicker, Leon, additional, Handelsman, David J., additional, Hankey, Graeme J., additional, Hannemann, Anke, additional, Haring, Robin, additional, Hsu, Benjumin, additional, Karlsson, Magnus, additional, Martin, Sean A., additional, Matsumoto, Alvin M., additional, Mellström, Dan, additional, Ohlsson, Claes, additional, O'Neill, Terence W., additional, Orwoll, Eric S., additional, Quartagno, Matteo, additional, Shores, Molly M., additional, Steveling, Antje, additional, Tivesten, Åsa, additional, Travison, Thomas G., additional, Vanderschueren, Dirk, additional, Wittert, Gary A., additional, Wu, Frederick C.W., additional, and Yeap, Bu B., additional

Published
2023
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28. Time to onset of antifracture efficacy and year‐by‐year persistence of effect of zoledronic acid in women with osteoporosis

Author

Boonen, Steven, Eastell, Richard, Su, Guoqin, Mesenbrink, Peter, Cosman, Felicia, Cauley, Jane A, Reid, Ian R, Claessens, Frank, Vanderschueren, Dirk, Lyles, Kenneth W, and Black, Dennis M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Osteoporosis, Aging, Clinical Trials and Supportive Activities, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Aged, Aged, 80 and over, Algorithms, Bone Density, Bone Density Conservation Agents, Diphosphonates, Double-Blind Method, Female, Humans, Imidazoles, Osteoporosis, Postmenopausal, Osteoporotic Fractures, Placebos, Proportional Hazards Models, Risk, Time Factors, Zoledronic Acid, FRACTURES, POSTMENOPAUSAL OSTEOPOROSIS, REACTION TIME, ZOLEDRONIC ACID, BONE MINERAL DENSITY, Biological Sciences, Engineering, Medical and Health Sciences, Anatomy & Morphology, Biological sciences, Biomedical and clinical sciences
Abstract

Oral bisphosphonates reduce fracture risk in osteoporotic patients but are often associated with poor compliance, which may impair their antifracture effects. This post hoc analysis assessed the time to onset and persistence of the antifracture effect of zoledronic acid, a once-yearly bisphosphonate infusion, in women with osteoporosis. Data from 9355 women who were randomized in two placebo-controlled pivotal trials were included. Endpoints included reduction in the rate of any clinical fracture at 6, 12, 18, 24, and 36 months in the zoledronic acid group compared with placebo, and the year-by-year incidence of all clinical fractures over 3 years. Cox proportional hazards regression was used to determine the timing of onset of antifracture efficacy. A generalized estimating equation model was used to assess fracture reduction for the 3 consecutive years of treatment, thereby evaluating persistence of effect. Safety results from women in the two studies were collated. Zoledronic acid reduced the risk of all clinical fractures at 12 months (hazard ratio [HR] = 0.75, 95% confidence interval [CI] 0.61-0.92, p = 0.0050) with significant reductions maintained at all subsequent time points. Year-by-year analysis showed that zoledronic acid reduced the risk for all clinical fractures compared with the placebo group in each of the 3 years (year 1: odds ratio [OR] = 0.74, 95% CI 0.60-0.91, p = 0.0044; year 2: OR = 0.53, 95% CI 0.42-0.66, p < 0.0001; year 3: OR = 0.61, 95% CI 0.48-0.77, p < 0.0001). This antifracture effect was persistent over 3 years, with the reductions in years 2 and 3 slightly larger than in year 1 (p = 0.097). This analysis shows that zoledronic acid offered significant protection from clinical fractures as early as 12 months. When administered annually, its beneficial effects persisted for at least 3 years.

Published
2012

30. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

Author

Abarca-Gómez, Leandra, Abdeen, Ziad A, Hamid, Zargar Abdul, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Acuin, Cecilia, Adams, Robert J, Aekplakorn, Wichai, Afsana, Kaosar, Aguilar-Salinas, Carlos A, Agyemang, Charles, Ahmadvand, Alireza, Ahrens, Wolfgang, Ajlouni, Kamel, Akhtaeva, Nazgul, Al-Hazzaa, Hazzaa M, Al-Othman, Amani Rashed, Al-Raddadi, Rajaa, Al Buhairan, Fadia, Al Dhukair, Shahla, Ali, Mohamed M, Ali, Osman, Alkerwi, Ala'a, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amouyel, Philippe, Amuzu, Antoinette, Andersen, Lars Bo, Anderssen, Sigmund A, Andrade, Dolores S, Ängquist, Lars H, Anjana, Ranjit Mohan, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Aryal, Krishna K, Aspelund, Thor, Assah, Felix K, Assunção, Maria Cecília F, Aung, May Soe, Avdicová, Mária, Azevedo, Ana, Azizi, Fereidoun, Babu, Bontha V, Bahijri, Suhad, Baker, Jennifer L, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Barbagallo, Carlo M, Barceló, Alberto, Barkat, Amina, Barros, Aluisio JD, Barros, Mauro VG, Bata, Iqbal, Batieha, Anwar M, Batista, Rosangela L, Batyrbek, Assembekov, Baur, Louise A, Beaglehole, Robert, Romdhane, Habiba Ben, Benedics, Judith, Benet, Mikhail, Bennett, James E, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bhatti, Zaid, Bhutta, Zulfiqar A, Bi, Hongsheng, Bi, Yufang, Biehl, Anna, Bikbov, Mukharram, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boeing, Heiner, Boggia, Jose G, Boissonnet, Carlos P, Bonaccio, Marialaura, Bongard, Vanina, Bovet, Pascal, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, 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Woodward, Mark, Wu, Frederick C, Wu, Jianfeng, Wu, Shouling, Xu, Haiquan, Xu, Liang, Yamborisut, Uruwan, Yan, Weili, Yang, Xiaoguang, Yardim, Nazan, Ye, Xingwang, Yiallouros, Panayiotis K, Yngve, Agneta, Yoshihara, Akihiro, You, Qi Sheng, Younger-Coleman, Novie O, Yusoff, Faudzi, Yusoff, Muhammad Fadhli M, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zhussupov, Baurzhan, Zimmermann, Esther, Cisneros, Julio Zuñiga, Bentham, James, Di Cesare, Mariachiara, Bilano, Ver, Bixby, Honor, Zhou, Bin, Stevens, Gretchen A, Riley, Leanne M, Taddei, Cristina, Hajifathalian, Kaveh, Lu, Yuan, Savin, Stefan, Cowan, Melanie J, Paciorek, Christopher J, Kengne, Andre Pascal, Zhu, Aubrianna, and Ezzati, Majid

Published
2017
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32. Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: results from the phase 2, randomised, double-blind, placebo-controlled MANTA and MANTA-RAy studies

Author

Reinisch, Walter, primary, Hellstrom, Wayne, additional, Dolhain, Radboud J E M, additional, Sikka, Suresh, additional, Westhovens, René, additional, Mehta, Rajiv, additional, Ritter, Timothy, additional, Seidler, Ursula, additional, Golovchenko, Oleksandr, additional, Simanenkov, Vladimir, additional, Garmish, Olena, additional, Jeka, Sławomir, additional, Moravcová, Radka, additional, Rajendran, Vijay, additional, Le Brun, Franck-Olivier, additional, Arterburn, Sarah, additional, Watkins, Timothy R, additional, Besuyen, Robin, additional, and Vanderschueren, Dirk, additional

Published
2023
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33. Sarcopenia‐defining parameters, but not sarcopenia, are associated with cognitive domains in middle‐aged and older European men

Author

Amini, Nadjia, primary, Dupont, Jolan, additional, Lapauw, Laurence, additional, Vercauteren, Laura, additional, Antonio, Leen, additional, O'Neill, Terence W., additional, Vanderschueren, Dirk, additional, Pendleton, Neil, additional, Rastrelli, Giulia, additional, Maggi, Mario, additional, Casanueva, Felipe F., additional, Słowikowska‐Hilczer, Jolanta, additional, Punab, Margus, additional, Huhtaniemi, Ilpo T., additional, Wu, Frederick C.W., additional, Verschueren, Sabine, additional, Tournoy, Jos, additional, and Gielen, Evelien, additional

Published
2023
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35. Glycemia but not the Metabolic Syndrome is Associated with Cognitive Decline: Findings from the European Male Ageing Study

Author

Overman, Margot J., Pendleton, Neil, O'Neill, Terence W., Bartfai, Gyorgy, Casanueva, Felipe F., Forti, Gianni, Rastrelli, Giulia, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E.J., Punab, Margus, Lee, David M., Correa, Elon S., Ahern, Tomas, Laurent, Michaël R., Verschueren, Sabine M.P., Antonio, Leen, Gielen, Evelien, Rutter, Martin K., Vanderschueren, Dirk, Wu, Frederick C.W., and Tournoy, Jos

Published
2017
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37. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

Author

Zhou, Bin, Bentham, James, Di Cesare, Mariachiara, Bixby, Honor, Danaei, Goodarz, Cowan, Melanie J, Paciorek, Christopher J, Singh, Gitanjali, Hajifathalian, Kaveh, Bennett, James E, Taddei, Cristina, Bilano, Ver, Carrillo-Larco, Rodrigo M, Djalalinia, Shirin, Khatibzadeh, Shahab, Lugero, Charles, Peykari, Niloofar, Zhang, Wan Zhu, Lu, Yuan, Stevens, Gretchen A, Riley, Leanne M, Bovet, Pascal, Elliott, Paul, Gu, Dongfeng, Ikeda, Nayu, Jackson, Rod T, Joffres, Michel, Kengne, Andre Pascal, Laatikainen, Tiina, Lam, Tai Hing, Laxmaiah, Avula, Liu, Jing, Miranda, J Jaime, Mondo, Charles K, Neuhauser, Hannelore K, Sundström, Johan, Smeeth, Liam, Soric, Maroje, Woodward, Mark, Ezzati, Majid, Abarca-Gómez, Leandra, Abdeen, Ziad A, Rahim, Hanan Abdul, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Adams, Robert, Aekplakorn, Wichai, Afsana, Kaosar, Aguilar-Salinas, Carlos A, Agyemang, Charles, Ahmadvand, Alireza, Ahrens, Wolfgang, Al Raddadi, Rajaa, Al Woyatan, Rihab, Ali, Mohamed M, Alkerwi, Ala'a, Aly, Eman, Amouyel, Philippe, Amuzu, Antoinette, Andersen, Lars Bo, Anderssen, Sigmund A, Ängquist, Lars, Anjana, Ranjit Mohan, Ansong, Daniel, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arlappa, Nimmathota, Aryal, Krishna, Arveiler, Dominique, Assah, Felix K, Assunção, Maria Cecília F, Avdicová, Mária, Azevedo, Ana, Azizi, Fereidoun, Babu, Bontha V, Bahijri, Suhad, Balakrishna, Nagalla, Bandosz, Piotr, Banegas, José R, Barbagallo, Carlo M, Barceló, Alberto, Barkat, Amina, Barros, Aluisio J D, Barros, Mauro V, Bata, Iqbal, Batieha, Anwar M, Baur, Louise A, Beaglehole, Robert, Romdhane, Habiba Ben, Benet, Mikhail, Benson, Lowell S, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Yufang, Bikbov, Mukharram, Bjerregaard, Peter, Bjertness, Espen, Björkelund, Cecilia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boeing, Heiner, Boggia, Jose G, Boissonnet, Carlos P, Bongard, Vanina, Braeckman, Lutgart, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Brenner, Hermann, Brewster, Lizzy M, Bruno, Graziella, Bueno-de-Mesquita, H B(as), Bugge, Anna, Burns, Con, Bursztyn, Michael, de León, Antonio Cabrera, Cacciottolo, Joseph, Cameron, Christine, Can, Günay, Cândido, Ana Paula C, Capuano, Vincenzo, Cardoso, Viviane C, Carlsson, Axel C, Carvalho, Maria J, Casanueva, Felipe F, Casas, Juan-Pablo, Caserta, Carmelo A, Chamukuttan, Snehalatha, Chan, Angelique W, Chan, Queenie, Chaturvedi, Himanshu K, Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Dekkaki, Imane Cherkaoui, Chetrit, Angela, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Cho, Belong, Cho, Yumi, Chudek, Jerzy, Cifkova, Renata, Claessens, Frank, Clays, Els, Concin, Hans, Cooper, Cyrus, Cooper, Rachel, Coppinger, Tara C, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crujeiras, Ana B, Cruz, Juan J, D'Arrigo, Graziella, d'Orsi, Eleonora, Dallongeville, Jean, Damasceno, Albertino, Dankner, Rachel, Dantoft, Thomas M, Dauchet, Luc, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, De Smedt, Delphine, Deepa, Mohan, Dehghan, Abbas, Delisle, Hélène, Deschamps, Valérie, Dhana, Klodian, Di Castelnuovo, Augusto F, Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Dickerson, Ty T, Do, Ha T P, Dobson, Annette J, Donfrancesco, Chiara, Donoso, Silvana P, Döring, Angela, Doua, Kouamelan, Drygas, Wojciech, Dulskiene, Virginija, Džakula, Aleksandar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eggertsen, Robert, Ekelund, Ulf, El Ati, Jalila, Ellert, Ute, Elosua, Roberto, Erasmus, Rajiv T, Erem, Cihangir, Eriksen, Louise, de la Peña, Jorge Escobedo, Evans, Alun, Faeh, David, Fall, Caroline H, Farzadfar, Farshad, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrieres, Jean, Finn, Joseph D, Fischer, Krista, Föger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Forsner, Maria, Fortmann, Stephen P, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Franco, Oscar H, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Gavrila, Diana, Geleijnse, Johanna M, Ghasemian, Anoosheh, Ghimire, Anup, Giampaoli, Simona, Gianfagna, Francesco, Giovannelli, Jonathan, Goldsmith, Rebecca A, Gonçalves, Helen, Gross, Marcela Gonzalez, Rivas, Juan P González, Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dušan, Grajda, Aneta, Gregor, Ronald D, Grodzicki, Tomasz, Grøntved, Anders, Gruden, Grabriella, Grujic, Vera, Guan, Ong Peng, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc, Gupta, Prakash C, Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Hadaegh, Farzad, Halkjær, Jytte, Hambleton, Ian R, Hardy, Rebecca, Harikumar, Rachakulla, Hata, Jun, Hayes, Alison J, He, Jiang, Hendriks, Marleen Elisabeth, Henriques, Ana, Cadena, Leticia Hernandez, Herrala, Sauli, Heshmat, Ramin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Hofman, Albert, Dinc, Gonul Horasan, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Hu, Yonghua, Huerta, José María, Husseini, Abdullatif S, Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iannone, Anna G, Ibrahim, M Mohsen, Ikram, M Arfan, Irazola, Vilma E, Islam, Muhammad, Ivkovic, Vanja, Iwasaki, Masanori, Jacobs, Jeremy M, Jafar, Tazeen, Jamrozik, Konrad, Janszky, Imre, Jasienska, Grazyna, Jelakovic, Bojan, Jiang, Chao Qiang, Johansson, Mattias, Jonas, Jost B, Jørgensen, Torben, Joshi, Pradeep, Juolevi, Anne, Jurak, Gregor, Jureša, Vesna, Kaaks, Rudolf, Kafatos, Anthony, Kalter-Leibovici, Ofra, Kamaruddin, Nor Azmi, Kasaeian, Amir, Katz, Joanne, Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli, Keil, Ulrich, Boker, Lital Keinan, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kemper, Han C G, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khang, Young-Ho, Khaw, Kay-Tee, Kiechl, Stefan, Killewo, Japhet, Kim, Jeongseon, Klumbiene, Jurate, Kolle, Elin, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kouda, Katsuyasu, Koziel, Slawomir, Kristensen, Peter Lund, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S, Kubinova, Ruzena, Kuciene, Renata, Kuh, Diana, Kujala, Urho M, Kula, Krzysztof, Kulaga, Zbigniew, Kumar, R Krishna, Kurjata, Pawel, Kusuma, Yadlapalli S, Kuulasmaa, Kari, Kyobutungi, Catherine, Lachat, Carl, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Laugsand, Lars E, Bao, Khanh Le Nguyen, Le, Tuyen D, Leclercq, Catherine, Lee, Jeannette, Lee, Jeonghee, Lehtimäki, Terho, Lekhraj, Rampal, León-Muñoz, Luz M, Levitt, Naomi S, Li, Yanping, Lilly, Christa L, Lim, Wei-Yen, Lima-Costa, M Fernanda, Lin, Hsien-Ho, Lin, Xu, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Lorbeer, Roberto, Lotufo, Paulo A, Lozano, José Eugenio, Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lytsy, Per, Ma, Guansheng, Ma, Jun, Machado-Coelho, George L L, Machi, Suka, Maggi, Stefania, Magliano, Dianna J, Majer, Marjeta, Makdisse, Marcia, Malekzadeh, Reza, Malhotra, Rahul, Rao, Kodavanti Mallikharjuna, Malyutina, Sofia, Manios, Yannis, Mann, Jim I, Manzato, Enzo, Margozzini, Paula, Marques-Vidal, Pedro, Marrugat, Jaume, Martorell, Reynaldo, Mathiesen, Ellisiv B, Matijasevich, Alicia, Matsha, Tandi E, Mbanya, Jean Claude N, Posso, Anselmo J Mc Donald, McFarlane, Shelly R, McGarvey, Stephen T, McLachlan, Stela, McLean, Rachael M, McNulty, Breige A, Khir, Amir Sharifuddin Md, Mediene-Benchekor, Sounnia, Medzioniene, Jurate, Meirhaeghe, Aline, Meisinger, Christa, Menezes, Ana Maria B, Menon, Geetha R, Meshram, Indrapal I, Metspalu, Andres, Mi, Jie, Mikkel, Kairit, Miller, Jody C, Miquel, Juan Francisco, Mišigoj-Durakovic, Marjeta, Mohamed, Mostafa K, Mohammad, Kazem, Mohammadifard, Noushin, Mohan, Viswanathan, Yusoff, Muhammad Fadhli Mohd, Møller, Niels C, Molnár, Dénes, Momenan, Amirabbas, Monyeki, Kotsedi Daniel K, Moreira, Leila B, Morejon, Alain, Moreno, Luis A, Morgan, Karen, Moschonis, George, Mossakowska, Malgorzata, Mostafa, Aya, Mota, Jorge, Motlagh, Mohammad Esmaeel, Motta, Jorge, Muiesan, Maria L, Müller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Musil, Vera, Nagel, Gabriele, Naidu, Balkish M, Nakamura, Harunobu, Námešná, Jana, Nang, Ei Ei K, Nangia, Vinay B, Narake, Sameer, Navarrete-Muñoz, Eva Maria, Ndiaye, Ndeye Coumba, Neal, William A, Nenko, Ilona, Nervi, Flavio, Nguyen, Nguyen D, Nguyen, Quang Ngoc, Nieto-Martínez, Ramfis E, Niiranen, Teemu J, Ning, Guang, Ninomiya, Toshiharu, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A, Noorbala, Ahmad Ali, Noorbala, Teresa, Noto, Davide, Al Nsour, Mohannad, O'Reilly, Dermot, Oh, Kyungwon, Olinto, Maria Teresa A, Oliveira, Isabel O, Omar, Mohd Azahadi, Onat, Altan, Ordunez, Pedro, Osmond, Clive, Ostojic, Sergej M, Otero, Johanna A, Overvad, Kim, Owusu-Dabo, Ellis, Paccaud, Fred Michel, Padez, Cristina, Pahomova, Elena, Pajak, Andrzej, Palli, Domenico, Palmieri, Luigi, Panda-Jonas, Songhomitra, Panza, Francesco, Papandreou, Dimitrios, Parnell, Winsome R, Parsaeian, Mahboubeh, Pecin, Ivan, Pednekar, Mangesh S, Peer, Nasheeta, Peeters, Petra H, Peixoto, Sergio Viana, Pelletier, Catherine, Peltonen, Markku, Pereira, Alexandre C, Pérez, Rosa Marina, Peters, Annette, Petkeviciene, Janina, Pham, Son Thai, Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pitakaka, Freda, Plans-Rubió, Pedro, Polakowska, Maria, Polašek, Ozren, Porta, Miquel, Portegies, Marileen LP, Pourshams, Akram, Pradeepa, Rajendra, Prashant, Mathur, Price, Jacqueline F, Puiu, Maria, Punab, Margus, Qasrawi, Radwan F, Qorbani, Mostafa, Radic, Ivana, Radisauskas, Ricardas, Rahman, Mahfuzar, Raitakari, Olli, Raj, Manu, Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramos, Elisabete, Rampal, Sanjay, Reina, Daniel A Rangel, Rasmussen, Finn, Redon, Josep, Reganit, Paul Ferdinand M, Ribeiro, Robespierre, Riboli, Elio, Rigo, Fernando, de Wit, Tobias F Rinke, Ritti-Dias, Raphael M, Robinson, Sian M, Robitaille, Cynthia, Rodríguez-Artalejo, Fernando, Rodriguez-Perez del Cristo, María, Rodríguez-Villamizar, Laura A, Rojas-Martinez, Rosalba, Rosengren, Annika, Rubinstein, Adolfo, Rui, Ornelas, Ruiz-Betancourt, Blanca Sandra, Horimoto, Andrea R V Russo, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S, Saidi, Olfa, Sakarya, Sibel, Salanave, Benoit, Salazar Martinez, Eduardo, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Sánchez-Abanto, Jose, Sans, Susana, Santos, Diana, Santos, Ina S, dos Santos, Renata Nunes, Santos, Rute, Saramies, Jouko L, Sardinha, Luis B, Margolis, Giselle Sarganas, Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savva, Savvas C, Scazufca, Marcia, Schargrodsky, Herman, Schneider, Ione J, Schultsz, Constance, Schutte, Aletta E, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Sharma, Sanjib K, Shaw, Jonathan E, Shibuya, Kenji, Shin, Dong Wook, Shin, Youchan, Siantar, Rosalynn, Sibai, Abla M, Silva, Diego Augusto Santos, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöström, Michael, Skovbjerg, Sine, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smith, Margaret C, Snijder, Marieke B, So, Hung-Kwan, Sobngwi, Eugène, Söderberg, Stefan, Solfrizzi, Vincenzo, Sonestedt, Emily, Song, Yi, Sørensen, Thorkild IA, Jérome, Charles Sossa, Soumare, Aicha, Staessen, Jan A, Starc, Gregor, Stathopoulou, Maria G, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stessman, Jochanan, Stieber, Jutta, Stöckl, Doris, Stocks, Tanja, Stokwiszewski, Jakub, Stronks, Karien, Strufaldi, Maria Wany, Sun, Chien-An, Sung, Yn-Tz, Suriyawongpaisal, Paibul, Sy, Rody G, Tai, E Shyong, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tang, Line, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarqui-Mamani, Carolina B, Taylor, Anne, Theobald, Holger, Thijs, Lutgarde, Thuesen, Betina H, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Topbas, Murat, Topór-Madry, Roman, Tormo, María José, Torrent, Maties, Traissac, Pierre, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh T H, Trivedi, Atul, Tshepo, Lechaba, Tulloch-Reid, Marshall K, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L, Tynelius, Per, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ulmer, Hanno, Uusitalo, Hannu M T, Valdivia, Gonzalo, Valvi, Damaskini, van der Schouw, Yvonne T, Van Herck, Koen, van Rossem, Lenie, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Vatten, Lars, Vega, Tomas, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Verschuren, W M Monique, Verstraeten, Roosmarijn, Victora, Cesar G, Viet, Lucie, Viikari-Juntura, Eira, Vineis, Paolo, Vioque, Jesus, Virtanen, Jyrki K, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vollenweider, Peter, Voutilainen, Sari, Vrdoljak, Ana, Vrijheid, Martine, Wade, Alisha N, Wagner, Aline, Walton, Janette, Mohamud, Wan Nazaimoon Wan, Wang, Ming-Dong, Wang, Qian, Wang, Ya Xing, Wannamethee, S Goya, Wareham, Nicholas, Wedderkopp, Niels, Weerasekera, Deepa, Whincup, Peter H, Widhalm, Kurt, Widyahening, Indah S, Wiecek, Andrzej, Wijga, Alet H, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Emmanuel A, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong, Tien Yin, Wong-McClure, Roy A, Woo, Jean, Wu, Aleksander Giwercman, Wu, Frederick C, Wu, Shou Ling, Xu, Haiquan, Yan, Weili, Yang, Xiaoguang, Ye, Xingwang, Yiallouros, Panayiotis K, Yoshihara, Akihiro, Younger-Coleman, Novie O, Yusoff, Ahmad F, Yusoff, Muhammad Fadhli M, Zambon, Sabina, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Yingffeng, Zhu, Dan, Zimmermann, Esther, and Zuñiga Cisneros, Julio

Published
2017
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38. The effect of testosterone treatment on bone mineral density in Klinefelter syndrome: A retrospective cohort study.

Author

Willems, Stien, David, Karel, Decallonne, Brigitte, Marcq, Philippe, Antonio, Leen, and Vanderschueren, Dirk

Subjects
BONE density, KLINEFELTER'S syndrome, TREATMENT effectiveness, OSTEOPOROSIS, BONE health
Abstract

Background: Although Klinefelter syndrome (KS) is the most frequent sex‐hormone disorder, there is ongoing uncertainty about the often associated sex‐hormone deficiency, its impact on common comorbidities, and therefore about prevention and treatment. In this study, we focus on bone loss, reported to occur in over 40% of KS patients, and the impact of testosterone replacement therapy (TRT) on this comorbidity. Objectives: This single‐center retrospective cohort study in a tertiary hospital compared the effect of treatment with TRT to no TRT on evolution of bone mineral density (BMD) in KS patients. Methods: After a medical chart review, a total of 52 KS subjects were included in this study. BMD was measured by dual‐energy X‐ray absorptiometry (DXA) and expressed as T‐scores. Results: The subjects were divided into three groups, according to TRT. In the subgroup that only started TRT after baseline measurements (mean age 31 years), we observed significant gain in BMD T‐score at the lumbar spine (0.58 ± 0.60, p = 0.003; mean gain of 0.62% areal BMD per year) and total femur T‐score (0.24 ± 0.39, p = 0.041; mean gain of 0.25% areal BMD per year) after a mean follow‐up period of 7.5 years. Compared to untreated subjects, a significant difference in evolution was demonstrated at the lumbar level (+0.58 ± 0.60 vs. −0.14 ± 0.42, p = 0.007). In untreated subjects with normal testosterone levels, a loss of BMD (−0.27 ± 0.37, p = 0.029; mean loss of 0.49% areal BMD per year) at the femoral neck was measured. This decline was equal to the predicted loss seen in the general male population. Conclusion: TRT results in BMD gain in patients with KS with testosterone deficiency, mainly at the lumbar spine. However, this effect is limited (0.62% per year). Patients who were not treated with TRT because of sufficient endogenous testosterone levels, showed only the predicted age‐related bone loss during follow‐up. The need for TRT in maintaining bone health in KS should be evaluated on an individual basis according to the degree of sex steroid deficiency. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Methodological aspects of in vivo axial loading in rodents:a systematic review

Author

Nepal, Ashwini Kumar, van Essen, Hubertus W., de Jongh, Renate T., van Schoor, Natasja M., Otten, René H. J., Vanderschueren, Dirk, Lips, Paul, and Bravenboer, Nathalie

Abstract

Axial loading in rodents provides a controlled setting for mechanical loading, because load and subsequent strain, frequency, number of cycles and rest insertion between cycles, are precisely defined. These methodological aspects as well as factors, such as ovariectomy, aging, and disuse may affect the outcome of the loading test, including bone mass, structure, and bone mineral density. This review aims to overview methodological aspects and modifying factors in axial loading on bone outcomes. A systematic literature search was performed in bibliographic databases until December 2021, which resulted in 2183 articles. A total of 144 articles were selected for this review: 23 rat studies, 74 mouse studies, and 47 knock out (KO) mouse studies. Results indicated that peak load, frequency, and number of loading cycles mainly affected the outcomes of bone mass, structure, and density in both rat and mouse studies. It is crucial to consider methodological parameters and modifying factors such as age, sex-steroid deficiency, and disuse in loading protocols for the prediction of loading-related bone outcomes.

Published
2023

42. Androgen therapy does not prevent bone loss and arterial calcifications in male rats with CKD

Author

David, Karel, primary, Dubois, Vanessa, additional, Verhulst, Anja, additional, Sommers, Vera, additional, Schollaert, Dieter, additional, Deboel, Ludo, additional, Moermans, Karen, additional, Carmeliet, Geert, additional, D'Haese, Patrick, additional, Vanderschueren, Dirk, additional, Claessens, Frank, additional, Evenepoel, Pieter, additional, and Decallonne, Brigitte, additional

Published
2023
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43. Diminishing benefits of urban living for children and adolescents’ growth and development

Author

NCD Risk Factor Collaboration (NCD-RisC), [missing], Mishra, Anu, Zhou, Bin, Rodriguez-Martinez, Andrea, Bixby, Honor, Singleton, Rosie K., Carrillo-Larco, Rodrigo M., Sheffer, Kate E., Paciorek, Christopher J., Bennett, James E., Lhoste, Victor, Iurilli, Maria L. C., Di Cesare, Mariachiara, Bentham, James, Phelps, Nowell H., Sophiea, Marisa K., Stevens, Gretchen A., Danaei, Goodarz, Cowan, Melanie J., Savin, Stefan, Riley, Leanne M., Gregg, Edward W., Aekplakorn, Wichai, Ahmad, Noor Ani, Baker, Jennifer L., Chirita-Emandi, Adela, Farzadfar, Farshad, Fink, Günther, Heinen, Mirjam, Ikeda, Nayu, Kengne, Andre P., Khang, Young-Ho, Laatikainen, Tiina, Laxmaiah, Avula, Ma, Jun, Monroy-Valle, Michele, Mridha, Malay K., Padez, Cristina P., Reynolds, Andrew, Sorić, Maroje, Starc, Gregor, Wirth, James P., Abarca-Gómez, Leandra, Abdeen, Ziad A., Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Abdul Rahim, Hanan F., Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M., Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J., Adu-Afarwuah, Seth, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N., Agdeppa, Imelda A., Aghazadeh-Attari, Javad, Aguenaou, Hassan, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H., Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M., Al-Lahou, Badreya, Al-Raddadi, Rajaa, Al Hourani, Huda M., Al Qaoud, Nawal M., Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A., Alexius, Sylvia, Ali, Mohamed M., Alkandari, Abdullah, Alkerwi, Ala’a, Alkhatib, Buthaina M., Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N., Etxezarreta, Pilar Amiano, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A., Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E., Arlappa, Nimmathota, Aryal, Krishna K., Aseffa, Nega, Aspelund, Thor, Assah, Felix K., Assembekov, Batyrbek, Assunção, Maria Cecília F., Aung, May Soe, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V., Jørgensen, Maja Bæksgaard, Baharudin, Azli, Bahijri, Suhad, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R., Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M., Filho, Valter Barbosa, Barceló, Alberto, Baretić, Maja, Barkat, Amina, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio J. D., Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz D., Bata, Iqbal, Batieha, Anwar M., Batista, Aline P., Batista, Rosangela L., Battakova, Zhamilya, Baur, Louise A., Bayauli, Pascal M., Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Rolandi, Gilda Estela Benitez, Bere, Elling, Bergh, Ingunn Holden, Berhane, Yemane, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Carrasola, Ximena Berrios, Bettiol, Heloísa, Beutel, Manfred E., Beybey, Augustin F., Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Biasch, Katia, Lele, Elysée Claude Bika, Bikbov, Mukharram M., Bista, Bihungum, Bjelica, Dusko J., Bjerregaard, Anne A., Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Björkelund, Cecilia, Bloch, Katia V., Blokstra, Anneke, Magnazu, Moran Blychfeld, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boer, Jolanda M. A., Boggia, Jose G., Bogova, Elena, Boissonnet, Carlos P., Bojesen, Stig E., Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Bovet, Pascal, Boymatova, Khadichamo, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Briceño, Yajaira, Brinduse, Lacramioara, Brito, Miguel, Brophy, Sinead, Brug, Johannes, Bruno, Graziella, Bugge, Anna, Buntinx, Frank, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, de León, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Caixeta, Roberta B., Cama, Tilema, Cameron, Christine, Camolas, José, Can, Günay, Cândido, Ana Paula C., Cañete, Felicia, Capanzana, Mario V., Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C., Carlsson, Axel C., Carmuega, Esteban, Carvalho, Joana, Casajús, José A., Casanueva, Felipe F., Casas, Maribel, Celikcan, Ertugrul, Censi, Laura, Cervantes‐Loaiza, Marvin, Cesar, Juraci A., Chamukuttan, Snehalatha, Chan, Angelique, Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J., Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai J. M., Chinnock, Anne, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, María-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G., Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Cirillo, Massimo, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Compañ-Gabucio, Laura-María, Concin, Hans, Confortin, Susana C., Cooper, Cyrus, Coppinger, Tara C., Corpeleijn, Eva, Cortés, Lilia Yadira, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crampin, Amelia C., Cross, Amanda J., Crujeiras, Ana B., Cruz, Juan J., Csányi, Tamás, Csilla, Semánová, Cucu, Alexandra M., Cui, Liufu, Cureau, Felipe V., Cuschieri, Sarah, Czenczek-Lewandowska, Ewelina, D’Arrigo, Graziella, d’Orsi, Eleonora, Dacica, Liliana, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T., Dankner, Rachel, Dantoft, Thomas M., Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, de Assis, Maria Alice Altenburg, De Backer, Gui, De Bacquer, Dirk, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, de Oliveira, Paula Duarte, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R., De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D., DeGennaro, Vincent, Delisle, Hélène, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Dereń, Katarzyna, Deschamps, Valérie, Dhimal, Meghnath, Di Castelnuovo, Augusto, Dias-da-Costa, Juvenal Soares, Díaz-Sánchez, María Elena, Diaz, Alejandro, Fernández, Pedro Díaz, Ripollés, María Pilar Díez, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha T. P., Dobson, Annette J., Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Dong, Yanhui, Donoso, Silvana P., Döring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A., Duboz, Priscilla, Duleva, Vesselka L., Dulskiene, Virginija, Dumith, Samuel C., Dushpanova, Anar, Dyussupova, Azhar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Egbagbe, Eruke E., Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ammari, Laila, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Endevelt, Ronit, Engle-Stone, Reina, Erasmus, Rajiv T., Erbel, Raimund, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G., Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhradiyev, Ildar, Fakhretdinova, Albina A., Fall, Caroline H., Faramarzi, Elnaz, Farjam, Mojtaba, Sant’Angelo, Victoria Farrugia, Fattahi, Mohammad Reza, Fawwad, Asher, Fawzi, Wafaie W., Feigl, Edit, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandes, Romulo A., Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Gerson, Ferrari, Marika, Ferrario, Marco M., Ferreccio, Catterina, Ferreira, Haroldo S., Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fisberg, Mauro, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fouad, Heba M., Francis, Damian K., do Carmo Franco, Maria, Fras, Zlatko, Frontera, Guillermo, Fuchs, Flavio D., Fuchs, Sandra C., Fujiati, Isti I., Fujita, Yuki, Fumihiko, Matsuda, Furdela, Viktoriya, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Cuesta, Manuel Galán, Galbarczyk, Andrzej, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Gao, Pei, Garcia-de-la-Hera, Manoli, Mérida, María José García, Solano, Marta García, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M., George, Ronnie, Ghaderi, Ebrahim, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gieger, Christian, Gill, Tiffany K., Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Gluškova, Natalja, Godara, Ramesh, Godos, Justyna, Gogen, Sibel, Goldberg, Marcel, Goltzman, David, Gómez, Georgina, Gómez, Jesús Humberto Gómez, Gomez, Luis F., Gómez, Santiago F., Gomula, Aleksandra, da Silva, Bruna Gonçalves Cordeiro, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D., Gonzalez-Chica, David A., González-Gil, Esther M., Gonzalez-Gross, Marcela, González-Leon, Margot, González-Rivas, Juan P., González-Villalpando, Clicerio, González-Villalpando, María-Elena, Gonzalez, Angel R., Gottrand, Frederic, Graça, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Gregório, Maria João, Grøholt, Else Karin, Grøntved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Guajardo, Viviana, Gualdi-Russo, Emanuela, Guallar-Castillón, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F., Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Gunter, Marc J., Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C., Gupta, Rajeev, Gureje, Oye, González, Enrique Gutiérrez, Gutierrez, Laura, Gutzwiller, Felix, Gwee, Xinyi, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A., Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R., Hamzeh, Behrooz, Hanekom, Willem A., Hange, Dominique, Hanif, Abu A. M., Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Kumar, Rachakulla Hari, Lassen, Tina Harmer, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J., He, Jiang, He, Yuan, He, Yuna, Heidinger-Felső, Regina, Heier, Margit, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, dos Santos Henrique, Rafael, Henriques, Ana, Cadena, Leticia Hernandez, Herrala, Sauli, Herrera-Cuenca, Marianella, Herrera, Victor M., Herter-Aeberli, Isabelle, Herzig, Karl-Heinz, Heshmat, Ramin, Hill, Allan G., Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Höfelmann, Doroteia A., Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hopman, Wilma M., Horimoto, Andrea R. V. R., Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Petrescu, Constanta Huidumac, Huisman, Martijn, Husseini, Abdullatif, Huu, Chinh Nguyen, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Iakupova, Ellina M., Ibarluzea, Jesús M., Ibrahim, Mohsen M., Wong, Norazizah Ibrahim, Ikram, M. Arfan, Iñiguez, Carmen, Iotova, Violeta, Irazola, Vilma E., Ishida, Takafumi, Isiguzo, Godsent C., Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ivanova-Pandourska, Ivaila Y., Iwasaki, Masanori, Jääskeläinen, Tuija, Jackson, Rod T., Jacobs, Jeremy M., Jadoul, Michel, Jafar, Tazeen, Jallow, Bakary, James, Kenneth, Jamil, Kazi M., Jamrozik, Konrad, Jansson, Anna, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jennings, Garry, Jiang, Chao Qiang, Jimenez, Ramon O., Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J., Jonas, Jost B., Jonnagaddala, Jitendra, Jørgensen, Torben, Joshi, Pradeep, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J., Judge, Debra S., Juolevi, Anne, Jurak, Gregor, Simina, Iulia Jurca, Juresa, Vesna, Kaaks, Rudolf, Kaducu, Felix O., Kafatos, Anthony, Kaj, Mónika, Kajantie, Eero O., Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kameli, Yves, Kampmann, Freja B., Kanala, Kodanda R., Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Kårhus, Line L., Karki, Khem B., Katchunga, Philippe B., Katibeh, Marzieh, Katz, Joanne, Katzmarzyk, Peter T., Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli M., Kaze, François F., Ke, Calvin, Keil, Ulrich, Boker, Lital Keinan, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han C. G., Keramati, Maryam, Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khaledifar, Arsalan, Khalili, Davood, Khaw, Kay-Tee, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Khouw, Ilse M. S. L., Kiechl-Kohlendorfer, Ursula, Kiechl, Sophia J., Kiechl, Stefan, Killewo, Japhet, Kim, Hyeon Chang, Kim, Jeongseon, Kindblom, Jenny M., Kingston, Andrew, Klakk, Heidi, Klimek, Magdalena, Klimont, Jeannette, Klumbiene, Jurate, Knoflach, Michael, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, König, Jürgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Kouda, Katsuyasu, Kovács, Éva, Kovacs, Viktoria Anna, Kovalskys, Irina, Kowlessur, Sudhir, Koziel, Slawomir, Kratenova, Jana, Kratzer, Wolfgang, Kriaucioniene, Vilma, Kriemler, Susi, Kristensen, Peter Lund, Krizan, Helena, Kroker-Lobos, Maria F., Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S., Kruger, Ruan, Kryst, Łukasz, Kubinova, Ruzena, Kuciene, Renata, Kujala, Urho M., Kujundzic, Enisa, Kulaga, Zbigniew, Kulimbet, Mukhtar, Kumar, R. Krishna, Kunešová, Marie, Kurjata, Pawel, Kusuma, Yadlapalli S., Kutsenko, Vladimir, Kuulasmaa, Kari, Kyobutungi, Catherine, La, Quang Ngoc, Laamiri, Fatima Zahra, Lachat, Carl, Lackner, Karl J., Laid, Youcef, Lall, Lachmie, Lam, Tai Hing, Jimenez, Maritza Landaeta, Landais, Edwige, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Larissa, Simo Pone, Latt, Tint Swe, Laurenzi, Martino, Lauria, Laura, Lazo-Porras, Maria, Le Coroller, Gwenaëlle, Le Nguyen Bao, Khanh, Le Port, Agnès, Le, Tuyen D., Lee, Jeannette, Lee, Jeonghee, Lee, Paul H., Lehmann, Nils, Lehtimäki, Terho, Lemogoum, Daniel, Leskošek, Branimir, Leszczak, Justyna, Leth-Møller, Katja B., Leung, Gabriel M., Levitt, Naomi S., Li, Yanping, Liivak, Merike, Lilly, Christa L., Lim, Charlie, Lim, Wei-Yen, Lima-Costa, M. Fernanda, Lin, Hsien-Ho, Lin, Xu, Lin, Yi-Ting, Lind, Lars, Lingam, Vijaya, Linkohr, Birgit, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Liu, Jing, Liu, Lijuan, Lo, Wei-Cheng, Loit, Helle-Mai, Long, Khuong Quynh, Abril, Guadalupe Longo, Lopes, Luis, Lopes, Marcus V. V., Lopes, Oscar, Lopez-Garcia, Esther, Lopez, Tania, Lotufo, Paulo A., Lozano, José Eugenio, Lukrafka, Janice L., Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lunogelo, Charles, Lustigová, Michala, Łuszczki, Edyta, M’Buyamba-Kabangu, Jean-René, Ma, Guansheng, Ma, Xu, Machado-Coelho, George L. L., Machado-Rodrigues, Aristides M., Macia, Enguerran, Macieira, Luisa M., Madar, Ahmed A., Madsen, Anja L., Maestre, Gladys E., Maggi, Stefania, Magliano, Dianna J., Magnacca, Sara, Magriplis, Emmanuella, Mahasampath, Gowri, Maire, Bernard, Majer, Marjeta, Makdisse, Marcia, Mäki, Päivi, Malekzadeh, Fatemeh, Malekzadeh, Reza, Malhotra, Rahul, Rao, Kodavanti Mallikharjuna, Malyutina, Sofia K., Maniego, Lynell V., Manios, Yannis, Manix, Masimango Imani, Mann, Jim I., Mansour-Ghanaei, Fariborz, Manyanga, Taru, Manzato, Enzo, Marcil, Anie, Margozzini, Paula, Mariño, Joany, Markaki, Anastasia, Markey, Oonagh, Ioannidou, Eliza Markidou, Marques-Vidal, Pedro, Marques, Larissa Pruner, Marrugat, Jaume, Martin-Prevel, Yves, Martin, Rosemarie, Martorell, Reynaldo, Martos, Eva, Maruszczak, Katharina, Marventano, Stefano, Masala, Giovanna, Mascarenhas, Luis P., Masoodi, Shariq R., Mathiesen, Ellisiv B., Mathur, Prashant, Matijasevich, Alicia, Matłosz, Piotr, Matsha, Tandi E., Matsudo, Victor, Mavrogianni, Christina, Mazur, Artur, Mbanya, Jean Claude N., McFarlane, Shelly R., McGarvey, Stephen T., McKee, Martin, McLachlan, Stela, McLean, Rachael M., McLean, Scott B., McNairy, Margaret L., McNulty, Breige A., Benchekor, Sounnia Mediene, Medzioniene, Jurate, Mehdipour, Parinaz, Mehlig, Kirsten, Mehrparvar, Amir Houshang, Meirhaeghe, Aline, Meisfjord, Jørgen, Meisinger, Christa, Melgarejo, Jesus D., Melkumova, Marina, Mello, João, Méndez, Fabián, Mendivil, Carlos O., Menezes, Ana Maria B., Menon, Geetha R., Mensink, Gert B. M., Menzano, Maria Teresa, Meshram, Indrapal I., Meto, Diane T., Mi, Jie, Michaelsen, Kim F., Michels, Nathalie, Mikkel, Kairit, Miłkowska, Karolina, Miller, Jody C., Milushkina, Olga, Minderico, Cláudia S., Mini, G. K., Miquel, Juan Francisco, Miranda, J. Jaime, Mirjalili, Mohammad Reza, Mirkopoulou, Daphne, Mirrakhimov, Erkin, Mišigoj-Duraković, Marjeta, Mistretta, Antonio, Mocanu, Veronica, Modesti, Pietro A., Moghaddam, Sahar Saeedi, Mohajer, Bahram, Mohamed, Mostafa K., Mohamed, Shukri F., Mohammad, Kazem, Mohammadi, Mohammad Reza, Mohammadi, Zahra, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohan, Viswanathan, Mohanna, Salim, Yusoff, Muhammad Fadhli Mohd, Mohebbi, Iraj, Mohebi, Farnam, Moitry, Marie, Møllehave, Line T., Møller, Niels C., Molnár, Dénes, Momenan, Amirabbas, Mondo, Charles K., Montenegro Mendoza, Roger A., Monterrubio-Flores, Eric, Monyeki, Kotsedi Daniel K., Moon, Jin Soo, Moosazadeh, Mahmood, Mopa, Hermine T., Moradpour, Farhad, Moreira, Leila B., Morejon, Alain, Moreno, Luis A., Morey, Francis, Morgan, Karen, Morin, Suzanne N., Mortensen, Erik Lykke, Moschonis, George, Moslem, Alireza, Mossakowska, Malgorzata, Mostafa, Aya, Mostafavi, Seyed-Ali, Mota-Pinto, Anabela, Mota, Jorge, Motlagh, Mohammad Esmaeel, Motta, Jorge, Moura-dos-Santos, Marcos André, Movsesyan, Yeva, Msyamboza, Kelias P., Mu, Thet Thet, Muc, Magdalena, Muca, Florian, Mugoša, Boban, Muiesan, Maria L., Müller-Nurasyid, Martina, Münzel, Thomas, Mursu, Jaakko, Murtagh, Elaine M., Musa, Kamarul Imran, Milanović, Sanja Musić, Musil, Vera, Musinguzi, Geofrey, Muyer, Muel Telo M. C., Nabipour, Iraj, Naderimagham, Shohreh, Nagel, Gabriele, Najafi, Farid, Nakamura, Harunobu, Nalecz, Hanna, Námešná, Jana, Nang, Ei Ei K., Nangia, Vinay B., Nankap, Martin, Narake, Sameer, Nardone, Paola, Naseri, Take, Nauck, Matthias, Neal, William A., Nejatizadeh, Azim, Nekkantti, Chandini, Nelis, Keiu, Nenko, Ilona, Neovius, Martin, Nervi, Flavio, Ng, Tze Pin, Nguyen, Chung T., Nguyen, Nguyen D., Nguyen, Quang Ngoc, Ni, Michael Y., Nicolescu, Rodica, Nie, Peng, Nieto-Martínez, Ramfis E., Nikitin, Yury P., Ning, Guang, Ninomiya, Toshiharu, Nishi, Nobuo, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A., Nogueira, Helena, Nordendahl, Maria, Nordestgaard, Børge G., Noto, Davide, Nowak-Szczepanska, Natalia, Nsour, Mohannad Al, Nuhoğlu, Irfan, Nunes, Baltazar, Nurk, Eha, Nuwaha, Fred, Nyirenda, Moffat, O’Neill, Terence W., O’Reilly, Dermot, Obreja, Galina, Ochimana, Caleb, Ochoa-Avilés, Angélica M., Oda, Eiji, Odili, Augustine N., Oh, Kyungwon, Ohara, Kumiko, Ohlsson, Claes, Ohtsuka, Ryutaro, Olafsson, Örn, Olinto, Maria Teresa A., Oliveira, Isabel O., Omar, Mohd Azahadi, Omar, Saeed M., Onat, Altan, Ong, Sok King, Onland-Moret, N. Charlotte, Ono, Lariane M., Ordunez, Pedro, Ornelas, Rui, Ortiz, Ana P., Ortiz, Pedro J., Osler, Merete, Osmond, Clive, Ostojic, Sergej M., Ostovar, Afshin, Otero, Johanna A., Overvad, Kim, Owusu-Dabo, Ellis, Paccaud, Fred Michel, Pagkalos, Ioannis, Pahomova, Elena, de Paiva, Karina Mary, Pająk, Andrzej, Palloni, Alberto, Palmieri, Luigi, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Pandey, Arvind, Panza, Francesco, Paoli, Mariela, Papadopoulou, Sousana K., Papandreou, Dimitrios, Pareja, Rossina G., Park, Soon-Woo, Park, Suyeon, Parnell, Winsome R., Parsaeian, Mahboubeh, Pascanu, Ionela M., Pasquet, Patrick, Patel, Nikhil D., Pattussi, Marcos, Pavlyshyn, Halyna, Pechlaner, Raimund, Pećin, Ivan, Pednekar, Mangesh S., Pedro, João M., Peer, Nasheeta, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C., Peres, Marco A., Pérez, Cynthia M., Peterkova, Valentina, Peters, Annette, Petersmann, Astrid, Petkeviciene, Janina, Petrauskiene, Ausra, Kovtun, Olga Petrovna, Pettenuzzo, Emanuela, Peykari, Niloofar, Pfeiffer, Norbert, Phall, Modou Cheyassin, Pham, Son Thai, Pichardo, Rafael N., Pierannunzio, Daniela, Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pistelli, Francesco, Pitakaka, Freda, Piwonska, Aleksandra, Pizarro, Andreia N., Plans-Rubió, Pedro, Platonova, Alina G., Poh, Bee Koon, Pohlabeln, Hermann, Polka, Nadija S., Pop, Raluca M., Popovic, Stevo R., Porta, Miquel, Posch, Georg, Poudyal, Anil, Poulimeneas, Dimitrios, Pouraram, Hamed, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J., Price, Jacqueline F., Prista, Antonio, Providencia, Rui, Puder, Jardena J., Pudule, Iveta, Puiu, Maria, Punab, Margus, Qadir, Muhammed S., Qasrawi, Radwan F., Qorbani, Mostafa, Quintana, Hedley K., Quiroga-Padilla, Pedro J., Bao, Tran Quoc, Rach, Stefan, Radic, Ivana, Radisauskas, Ricardas, Rahimikazerooni, Salar, Rahman, Mahfuzar, Rahman, Mahmudur, Raitakari, Olli, Raj, Manu, Rajabov, Tamerlan, Rakhmatulloev, Sherali, Rakovac, Ivo, Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramadan, Otim P. C., Ramires, Virgílio V., Ramke, Jacqueline, Ramos, Elisabete, Ramos, Rafel, Rampal, Lekhraj, Rampal, Sanjay, Rangelova, Lalka S., Rarra, Vayia, Rascon-Pacheco, Ramon A., Rech, Cassiano Ricardo, Redon, Josep, Reganit, Paul Ferdinand M., Regecová, Valéria, Renner, Jane D. P., Repasy, Judit A., Reuter, Cézane P., Revilla, Luis, Rezaianzadeh, Abbas, Rho, Yeunsook, Ribas-Barba, Lourdes, Ribeiro, Robespierre, Riboli, Elio, Richter, Adrian, Rigo, Fernando, Rigotti, Attilio, Rinaldo, Natascia, Rinke de Wit, Tobias F., Rito, Ana I., Ritti-Dias, Raphael M., Rivera, Juan A., Roa, Reina G., Robinson, Louise, Robitaille, Cynthia, Roccaldo, Romana, Rodrigues, Daniela, Rodríguez-Artalejo, Fernando, del Cristo Rodriguez-Perez, María, Rodríguez-Villamizar, Laura A., Rodríguez, Andrea Y., Roggenbuck, Ulla, Rohloff, Peter, Rohner, Fabian, Rojas-Martinez, Rosalba, Rojroongwasinkul, Nipa, Romaguera, Dora, Romeo, Elisabetta L., Rosario, Rafaela V., Rosengren, Annika, Rouse, Ian, Rouzier, Vanessa, Roy, Joel G. R., Ruano, Maira H., Rubinstein, Adolfo, Rühli, Frank J., Ruidavets, Jean-Bernard, Ruiz-Betancourt, Blanca Sandra, Ruiz-Castell, Maria, Moreno, Emma Ruiz, Rusakova, Iuliia A., Jonsson, Kenisha Russell, Russo, Paola, Rust, Petra, Rutkowski, Marcin, Saamel, Marge, Sabanayagam, Charumathi, Sabbaghi, Hamideh, Sacchini, Elena, Sachdev, Harshpal S., Sadjadi, Alireza, Safarpour, Ali Reza, Safi, Sare, Safiri, Saeid, Saghi, Mohammad Hossien, Saidi, Olfa, Saki, Nader, Šalaj, Sanja, Salanave, Benoit, Martinez, Eduardo Salazar, Saleva, Calogero, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T., Salvetti, Massimo, Samoutian, Margarita, Sánchez-Abanto, Jose, Rodríguez, Inés Sánchez, Sandjaja, [missing], Sans, Susana, Marina, Loreto Santa, Santacruz, Ethel, Santos, Diana A., Santos, Ina S., Santos, Lèlita C., Santos, Maria Paula, Santos, Osvaldo, Santos, Rute, Santos, Tamara R., Saramies, Jouko L., Sardinha, Luis B., Sarrafzadegan, Nizal, Sathish, Thirunavukkarasu, Saum, Kai-Uwe, Savva, Savvas, Savy, Mathilde, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D., Rosario, Angelika Schaffrath, Schargrodsky, Herman, Schienkiewitz, Anja, Schindler, Karin, Schipf, Sabine, Schmidt, Carsten O., Schmidt, Ida Maria, Schneider, Andrea, Schnohr, Peter, Schöttker, Ben, Schramm, Sara, Schramm, Stine, Schröder, Helmut, Schultsz, Constance, Schulze, Matthias B., Schutte, Aletta E., Sebert, Sylvain, Sedaghattalab, Moslem, Selamat, Rusidah, Sember, Vedrana, Sen, Abhijit, Senbanjo, Idowu O., Sepanlou, Sadaf G., Sequera, Guillermo, Serra-Majem, Luis, Servais, Jennifer, Ševčíková, Ľudmila, Shalnova, Svetlana, Shamah-Levy, Teresa, Shamshirgaran, Seyed Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K., Shaw, Jonathan E., Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shimony, Tal, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M., Sidossis, Labros S., Silitrari, Natalia, Silva, Antonio M., de Moura Silva, Caroline Ramos, Silva, Diego Augusto Santos, Silva, Kelly S., Sim, Xueling, Simon, Mary, Simons, Judith, Simons, Leon A., Sjöberg, Agneta, Sjöström, Michael, Skoblina, Natalia A., Skodje, Gry, Slazhnyova, Tatyana, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Söderberg, Stefan, Soekatri, Moesijanti Y. E., Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Soofi, Sajid, Sørensen, Thorkild I. A., Sørgjerd, Elin P., Jérome, Charles Sossa, Soto-Rojas, Victoria E., Soumaré, Aïcha, Sousa-Poza, Alfonso, Sovic, Slavica, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Spencer, Phoebe R., Spinelli, Angela, Spiroski, Igor, Staessen, Jan A., Stamm, Hanspeter, Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D., Stergiou, George S., Stessman, Jochanan, Stevanović, Ranko, Stieber, Jutta, Stöckl, Doris, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Strufaldi, Maria Wany, Sturua, Lela, Suárez-Medina, Ramón, Suka, Machi, Sun, Chien-An, Sun, Liang, Sundström, Johan, Sung, Yn-Tz, Sunyer, Jordi, Suriyawongpaisal, Paibul, Sweis, Nabil William G., Swinburn, Boyd A., Sy, Rody G., Sylva, René Charles, Szklo, Moyses, Szponar, Lucjan, Tabone, Lorraine, Tai, E. Shyong, Tambalis, Konstantinos D., Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanrygulyyeva, Maya, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B., Braunerová, Radka Taxová, Taylor, Anne, Taylor, Julie, Tchibindat, Félicité, Te Velde, Saskia, Tebar, William R., Tell, Grethe S., Tello, Tania, Tham, Yih Chung, Thankappan, K. R., Theobald, Holger, Theodoridis, Xenophon, Thomas, Nihal, Thorand, Barbara, Thuesen, Betina H., Tichá, Ľubica, Timmermans, Erik J., Tjandrarini, Dwi H., Tjonneland, Anne, Tolonen, Hanna K., Tolstrup, Janne S., Topbas, Murat, Topór-Mądry, Roman, Torheim, Liv Elin, Tormo, María José, Tornaritis, Michael J., Torrent, Maties, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Tremblay, Mark S., Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh T. H., Trivedi, Atul, Tsao, Yu-Hsiang, Tshepo, Lechaba, Tsigga, Maria, Tsintavis, Panagiotis, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M., Tulloch-Reid, Marshall K., Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L., Twig, Gilad, Tynelius, Per, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ukoli, Flora A. M., Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu M. T., Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M., van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T., Van Herck, Koen, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M., van Valkengoed, Irene G. M., Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Varona-Pérez, Patricia, Vasan, Senthil K., Vasques, Daniel G., Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, W. M. Monique, Victora, Cesar G., Viegi, Giovanni, Viet, Lucie, Vik, Frøydis N., Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Virtanen, Jyrki K., Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Voutilainen, Ari, Vrijheid, Martine, Vrijkotte, Tanja G. M., Wade, Alisha N., Waldhör, Thomas, Walton, Janette, Wambiya, Elvis O. A., Bebakar, Wan Mohamad Wan, Mohamud, Wan Nazaimoon Wan, de Souza Wanderley Júnior, Rildo, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S. Goya, Wareham, Nicholas, Weber, Adelheid, Webster-Kerr, Karen, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D., Whincup, Peter H., Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S., Więcek, Andrzej, Wild, Philipp S., Wilks, Rainford J., Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wojciech, Rusek, Wojtyniak, Bogdan, Wolf, Kathrin, Wong-McClure, Roy A., Wong, Andrew, Wong, Emily B., Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C., Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, García, Martha Yépez, Yiallouros, Panayiotis K., Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O., Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A., Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A., Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Vrkic, Tajana Zeljkovic, Zeng, Yi, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V., Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Cisneros, Julio Zuñiga, Zuziak, Monika, Bhutta, Zulfiqar A., Black, Robert E., and Ezzati, Majid

Subjects
Developing world, Public health, Multidisciplinary, Science General, Paediatric research, Nutrition
Abstract

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was

Published
2023

45. The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort

Author

Ivell, Richard, primary, Heng, Kee, additional, Severn, Katie, additional, Antonio, Leen, additional, Bartfai, Gyorgy, additional, Casanueva, Felipe F., additional, Huhtaniemi, Ilpo T., additional, Giwercman, Aleksander, additional, Maggi, Mario, additional, O’Connor, Daryl B., additional, O’Neill, Terence W., additional, Punab, Margus, additional, Rastrelli, Giulia, additional, Slowikowska-Hilczer, Jolanta, additional, Tournoy, Jos, additional, Vanderschueren, Dirk, additional, Wu, Frederick C. W., additional, and Anand-Ivell, Ravinder, additional

Published
2022
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46. The influence of proteoforms: assessing the accuracy of total vitamin D-binding protein quantification by proteolysis and LC-MS/MS

Author

Kilpatrick, Lisa E., primary, Bouillon, Roger, additional, Davis, W. Clay, additional, Henderson, Clark M., additional, Hoofnagle, Andrew N., additional, Pauwels, Steven, additional, Vanderschueren, Dirk, additional, Waelkens, Etienne, additional, Wildiers, Hans, additional, Yen, James H., additional, and Phinney, Karen W., additional

Published
2022
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47. Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study

Author

Overman, Margot J., Pendleton, Neil, O’Neill, Terence W., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Rastrelli, Giulia, Giwercman, Aleksander, Han, Thang S., Huhtaniemi, Ilpo T., Kula, Krzysztof, Lean, Michael E. J., Punab, Margus, Lee, David M., Correa, Elon S., Ahern, Tomas, Verschueren, Sabine M. P., Antonio, Leen, Gielen, Evelien, Rutter, Martin K., Vanderschueren, Dirk, Wu, Frederick C. W., Tournoy, Jos, and The EMAS Study Group

Published
2017
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48. Changes in prevalence of obesity and high waist circumference over four years across European regions: the European male ageing study (EMAS)

Author

Han, Thang S., Correa, Elon, Lean, Michael E. J., Lee, David M., O’Neill, Terrence W., Bartfai, György, Forti, Gianni, Giwercman, Aleksander, Kula, Krzysztof, Pendleton, Neil, Punab, Margus, Rutter, Martin K., Vanderschueren, Dirk, Huhtaniemi, Ilpo T., Wu, Frederick C. W., Casanueva, Felipe F., and and the EMAS Study Group

Published
2017
Full Text
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