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261 results on '"VOHRA, NASREEN A."'

2. Pathobiologic Stratification of Oncotype DX Recurrence Scores and Comparative Validation of 3 Surrogate Models

Author

Mohamed, Anas, Kousar, Aisha, Wong, Jan, Vohra, Nasreen, Muzaffar, Mahvish, and Geradts, Joseph

Subjects
Cancer -- Relapse, Breast cancer -- Diagnosis -- Development and progression -- Care and treatment, Health
Abstract

* Context.--The Oncotype DX Recurrence Score (RS) predicts recurrence and chemotherapy benefit in early-stage estrogen receptor-positive breast cancer patients. Cost and unavailability are 2 major disadvantages of the assay. Multiple models have been developed to predict the RS. Objective.--To predict RS based on histopathologic and biomarker features, and to measure concordance and correlation with RS of the following 3 algorithms: breast cancer prognostic score, Magee0, and Magee2. Design.--Breast cancer cases with available RSs were reviewed (n = 442). RS categories were stratified by pathologic and biomarker variables. Histopathologic and biomarker data were abstracted from pathology reports, and RS was calculated by each model. Correlation and concordance between models and RS were calculated. Results.--Less than 5% of breast cancers with lobular features, low-grade tumors, carcinomas with high progesterone receptor content, or luminal A tumors had an RS greater than 25. Breast cancer prognostic score, Magee0, and Magee2 demonstrated correlation coefficients with RS of 0.63, 0.61, and 0.62, respectively. Two-step discordances were uncommon. When an RS of 25 was used to separate high-risk from non-high-risk cases, concordance rates of 86% to 88% were achieved. Conclusions.--High RS was observed only in a small percentage of pure or mixed lobular carcinomas, low-grade or luminal A tumors, and tumors with high progesterone receptor expression, suggesting that these cancers may not require Oncotype testing. All 3 surrogate models demonstrated comparable correlation and high concordance with the RS when a cutoff of 25 was used, suggesting their utility in cases where the actual RS is unavailable. doi: 10.5858/arpa.2021-0367-OA, Breast cancer is the most common cancer in women. Several multigene-based assays have been developed to predict the outcome of breast cancer and guide adjuvant systemic therapy. The Oncotype DX [...]

Published
2022
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5. Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival

Author

Singhal, Sandeep K., Byun, Jung S., Park, Samson, Yan, Tingfen, Yancey, Ryan, Caban, Ambar, Hernandez, Sara Gil, Hewitt, Stephen M., Boisvert, Heike, Hennek, Stephanie, Bobrow, Mark, Ahmed, Md Shakir Uddin, White, Jason, Yates, Clayton, Aukerman, Andrew, Vanguri, Rami, Bareja, Rohan, Lenci, Romina, Farré, Paula Lucia, De Siervi, Adriana, Nápoles, Anna María, Vohra, Nasreen, and Gardner, Kevin

Published
2021
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11. Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across tumor types

Author

Boykov, Ilya, primary, Montgomery, McLane, additional, Hagen, James, additional, Aruleba, Raphael, additional, McLaughlin, Kelsey, additional, Coalson, Hannah, additional, Nelson, Margaret, additional, Pereyra, Andrea, additional, Ellis, Jessica, additional, Zeczycki, Tonya, additional, Vohra, Nasreen, additional, Tan, Su-Fern, additional, Cabot, Myles, additional, and Fisher-Wellman, Kelsey, additional

Published
2023
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14. Supplemental Table 2 from Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival

Author

Byun, Jung S., primary, Singhal, Sandeep K., primary, Park, Samson, primary, Yi, Dae Ik, primary, Yan, Tingfen, primary, Caban, Ambar, primary, Jones, Alana, primary, Mukhopadhyay, Partha, primary, Gil, Sara M., primary, Hewitt, Stephen M., primary, Newman, Lisa, primary, Davis, Melissa B., primary, Jenkins, Brittany D., primary, Sepulveda, Jorge L., primary, De Siervi, Adriana, primary, Nápoles, Anna María, primary, Vohra, Nasreen A., primary, and Gardner, Kevin, primary

Published
2023
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15. Supplemental Figure 2 from Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival

Author

Byun, Jung S., primary, Singhal, Sandeep K., primary, Park, Samson, primary, Yi, Dae Ik, primary, Yan, Tingfen, primary, Caban, Ambar, primary, Jones, Alana, primary, Mukhopadhyay, Partha, primary, Gil, Sara M., primary, Hewitt, Stephen M., primary, Newman, Lisa, primary, Davis, Melissa B., primary, Jenkins, Brittany D., primary, Sepulveda, Jorge L., primary, De Siervi, Adriana, primary, Nápoles, Anna María, primary, Vohra, Nasreen A., primary, and Gardner, Kevin, primary

Published
2023
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16. Supplemental Figure 4 from Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival

Author

Byun, Jung S., primary, Singhal, Sandeep K., primary, Park, Samson, primary, Yi, Dae Ik, primary, Yan, Tingfen, primary, Caban, Ambar, primary, Jones, Alana, primary, Mukhopadhyay, Partha, primary, Gil, Sara M., primary, Hewitt, Stephen M., primary, Newman, Lisa, primary, Davis, Melissa B., primary, Jenkins, Brittany D., primary, Sepulveda, Jorge L., primary, De Siervi, Adriana, primary, Nápoles, Anna María, primary, Vohra, Nasreen A., primary, and Gardner, Kevin, primary

Published
2023
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17. Supplemental Figure 1 from Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival

Author

Byun, Jung S., primary, Singhal, Sandeep K., primary, Park, Samson, primary, Yi, Dae Ik, primary, Yan, Tingfen, primary, Caban, Ambar, primary, Jones, Alana, primary, Mukhopadhyay, Partha, primary, Gil, Sara M., primary, Hewitt, Stephen M., primary, Newman, Lisa, primary, Davis, Melissa B., primary, Jenkins, Brittany D., primary, Sepulveda, Jorge L., primary, De Siervi, Adriana, primary, Nápoles, Anna María, primary, Vohra, Nasreen A., primary, and Gardner, Kevin, primary

Published
2023
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18. Supplemental Figure 5 from Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival

Author

Byun, Jung S., primary, Singhal, Sandeep K., primary, Park, Samson, primary, Yi, Dae Ik, primary, Yan, Tingfen, primary, Caban, Ambar, primary, Jones, Alana, primary, Mukhopadhyay, Partha, primary, Gil, Sara M., primary, Hewitt, Stephen M., primary, Newman, Lisa, primary, Davis, Melissa B., primary, Jenkins, Brittany D., primary, Sepulveda, Jorge L., primary, De Siervi, Adriana, primary, Nápoles, Anna María, primary, Vohra, Nasreen A., primary, and Gardner, Kevin, primary

Published
2023
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19. Supplemental Figure 3 from Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival

Author

Byun, Jung S., primary, Singhal, Sandeep K., primary, Park, Samson, primary, Yi, Dae Ik, primary, Yan, Tingfen, primary, Caban, Ambar, primary, Jones, Alana, primary, Mukhopadhyay, Partha, primary, Gil, Sara M., primary, Hewitt, Stephen M., primary, Newman, Lisa, primary, Davis, Melissa B., primary, Jenkins, Brittany D., primary, Sepulveda, Jorge L., primary, De Siervi, Adriana, primary, Nápoles, Anna María, primary, Vohra, Nasreen A., primary, and Gardner, Kevin, primary

Published
2023
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20. Supplemental data from Racial Differences in the Association Between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival

Author

Byun, Jung S., primary, Singhal, Sandeep K., primary, Park, Samson, primary, Yi, Dae Ik, primary, Yan, Tingfen, primary, Caban, Ambar, primary, Jones, Alana, primary, Mukhopadhyay, Partha, primary, Gil, Sara M., primary, Hewitt, Stephen M., primary, Newman, Lisa, primary, Davis, Melissa B., primary, Jenkins, Brittany D., primary, Sepulveda, Jorge L., primary, De Siervi, Adriana, primary, Nápoles, Anna María, primary, Vohra, Nasreen A., primary, and Gardner, Kevin, primary

Published
2023
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21. Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein

Author

Byun, Jung S., Park, Samson, Yi, Dae Ik, Shin, Jee-Hye, Hernandez, Sara Gil, Hewitt, Stephen M., Nicklaus, Marc C., Peach, Megan L., Guasch, Laura, Tang, Binwu, Wakefield, Lalage M., Yan, Tingfen, Caban, Ambar, Jones, Alana, Kabbout, Mohamed, Vohra, Nasreen, Nápoles, Anna María, Singhal, Sandeep, Yancey, Ryan, De Siervi, Adriana, and Gardner, Kevin

Published
2019
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24. Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race

Author

Singhal, Sandeep K., primary, Byun, Jung S., additional, Yan, Tingfen, additional, Yancey, Ryan, additional, Caban, Ambar, additional, Gil Hernandez, Sara, additional, Bufford, Sediqua, additional, Hewitt, Stephen M., additional, Winfield, Joy, additional, Pradhan, Jaya, additional, Mustkov, Vesco, additional, McDonald, Jasmine A., additional, Pérez-Stable, Eliseo J., additional, Nápoles, Anna María, additional, Vohra, Nasreen, additional, De Siervi, Adriana, additional, Yates, Clayton, additional, Davis, Melissa B., additional, Yang, Mei, additional, Tsai, Yien Che, additional, Weissman, Allan M., additional, and Gardner, Kevin, additional

Published
2022
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25. Bioenergetic Phenotyping of DEN-Induced Hepatocellular Carcinoma Reveals a Link Between Adenylate Kinase Isoform Expression and Reduced Complex I-Supported Respiration

Author

McLaughlin, Kelsey L., primary, Nelson, Margaret A.M., additional, Coalson, Hannah S., additional, Hagen, James T., additional, Montgomery, McLane M., additional, Wooten, Ashley R., additional, Zeczycki, Tonya N., additional, Vohra, Nasreen A., additional, and Fisher-Wellman, Kelsey H., additional

Published
2022
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35. Race-Related Differences in the Clinical Presentation and Histopathologic Features of Phyllodes Tumor

Author

Johnson, Helen M., Mohamed, Anas, Hassan, Muhammad M., Geradts, Joseph, Geisel, Lauren, Vohra, Nasreen A., and Wong, Jan H.

Abstract

Background Phyllodes tumor (PT) is a rare fibroepithelial lesion of the breast with variable malignant potential. Black women have a higher incidence of a related benign tumor, fibroadenoma, but there are limited epidemiological data on PT. The aim of our study was to evaluate race-related differences in the clinicopathologic features and outcomes of PT.Methods Our institutional pathology database was queried for breast specimen reports from 01/2009 to 10/2019 to identify patients with a pathologic diagnosis of PT. Chart review and detailed slide review were performed to obtain clinical and histopathologic variables, respectively.Results Among twelve patients, two had malignant PT, three had borderline PT, and seven had benign PT. All patients with malignant and borderline PT were black, compared with 29% of those with benign PT. There were no apparent race-related differences in specific histopathologic features among black vs. non-black women with benign PT. Malignant and borderline PT were relatively larger than benign PT, with mean tumor sizes of 9.0 cm (standard deviation [SD] 4.7 cm), 12.2 cm (SD 9.4 cm), and 5.4 cm (SD 5.8 cm), respectively. Two women had a local recurrence, both of whom were black.Discussion In this single-institution retrospective study, we observed disproportionate rates of aggressive histopathologic features and disparate outcomes among black women with PT. A multi-institutional PT registry would facilitate improved knowledge about race-related differences in the presentation and outcomes of this rare tumor.

Published
2023
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42. Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Author

Nelson, Margaret AM, primary, McLaughlin, Kelsey L, additional, Hagen, James T, additional, Coalson, Hannah S, additional, Schmidt, Cameron, additional, Kassai, Miki, additional, Kew, Kimberly A, additional, McClung, Joseph M, additional, Neufer, P Darrell, additional, Brophy, Patricia, additional, Vohra, Nasreen A, additional, Liles, Darla, additional, Cabot, Myles C, additional, and Fisher-Wellman, Kelsey H, additional

Published
2021
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43. Author response: Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Author

Nelson, Margaret AM, primary, McLaughlin, Kelsey L, additional, Hagen, James T, additional, Coalson, Hannah S, additional, Schmidt, Cameron, additional, Kassai, Miki, additional, Kew, Kimberly A, additional, McClung, Joseph M, additional, Neufer, P Darrell, additional, Brophy, Patricia, additional, Vohra, Nasreen A, additional, Liles, Darla, additional, Cabot, Myles C, additional, and Fisher-Wellman, Kelsey H, additional

Published
2021
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44. A gp78/AMFR protein-driven gene signature that predicts breast cancer outcome.

Author

Singhal, Sandeep K., primary, Byun, Jung, additional, Park, Samson, additional, Yan, Tingfen, additional, Yancey, Ryan, additional, Caban, Ambar, additional, Yates, Clayton, additional, Farré, Paula Lucia, additional, Siervi, Adriana De, additional, Napoles, Anna, additional, Vohra, Nasreen A., additional, Weissman, Allan M., additional, Yang, Mei, additional, Tsai, Yien Che, additional, and Gardner, Kevin, additional

Published
2021
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45. Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia.

Author

Nelson, Margaret, primary, McLaughlin, Kelsey, additional, Hagen, James, additional, Coalson, Hannah, additional, Schmidt, Cameron, additional, Kassai, Miki, additional, Kew, Kimberly, additional, McClung, Joseph, additional, Neufer, P., additional, Brophy, Patricia, additional, Vohra, Nasreen, additional, Liles, Darla, additional, Cabot, Myles, additional, and Fisher-Wellman, Kelsey, additional

Published
2021
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47. Racial Disparity in the Surgical Management of Diverticular Disease.

Author

Akram, Warqaa M., Vohra, Nasreen, Irish, William, Zervos, Emmanuel E., and Wong, Jan

Subjects
*MINIMALLY invasive procedures, *COLECTOMY, *RETROSPECTIVE studies, *SURGICAL complications, *LAPAROSCOPY, *DIVERTICULITIS
Abstract

Introduction: Although minimally invasive surgery (MIS) has clearly been associated with improved colorectal surgery outcomes, not all populations benefit from this approach. Using a national database, we analyzed both, the trend in the utilization of MIS for diverticulitis and differences in utilization by race.Methods: Colon-targeted participant user files (PUFs) from 2012 to 18 were linked to respective PUFs in National Surgical Quality Improvement Project. Patients undergoing colectomy for acute diverticulitis or chronic diverticular disease were included. Surgical approach was stratified by race and year. To adjust for confounding and estimate the association of covariates with approach, data were fit using multivariable binary logistic regression main effects model. Using a joint effects model, we evaluated whether the odds of a particular approach over time was differentially affected by race.Results: Of the 46 713 patients meeting inclusion criteria, 83% were white, with 7% black and 10% other. Over the study period, there was a decrease in the rate of open colectomy of about 5% P < .001, and increase in the rate of utilization of laparoscopic and robotic approaches (RC) P < .0001. After adjusting for confounders, black race was associated with open surgery P < .0001.Conclusion: There is disparity in the utilization of MIS for diverticulitis. Further research into the reasons for this disparity is critical to ensure known benefits of MIC are realized across all races. [ABSTRACT FROM AUTHOR]

Published
2022
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50. List of Contributors

Author

Ahlgrimm-Siess, Verena, primary, Almquist, Samuel Fehring, additional, Amini, Sadegh, additional, Andtbacka, Robert H.I., additional, Antonovich, Diana D., additional, Arbiser, Jack L., additional, Baumann, Donald, additional, Berman, Brian, additional, Berrios, Ricardo L., additional, Bhambri, Avani, additional, Bhambri, Sanjay, additional, Bolognia, Jean L., additional, Bowles, Tawnya L., additional, Brown, Marc David, additional, Burnett, Christopher T., additional, Butow, Phyllis Nancy, additional, Callen, Jeffrey P., additional, Carucci, John A., additional, Cather, Jennifer Clay, additional, Ceilley, Roger I., additional, Cerroni, Lorenzo, additional, Chang, Jason, additional, Chen, Suephy C., additional, Chiang, Melissa, additional, Clayton, Anna Sancho, additional, Cockerell, Clay J., additional, Colegio, Oscar R., additional, Coleman King, Sallyann M., additional, Cooper, Jay S., additional, Curiel-Lewandowski, Clara, additional, Del Rosso, James Q., additional, Demierre, The late Marie-France, additional, Dinehart, Scott, additional, Driscoll, Marcia S., additional, Eide, Melody J., additional, Elston, Dirk M., additional, Fine, Jo-David, additional, Friedman, Robert J., additional, Gershenwald, Jeffrey E., additional, Gold, Kathryn A., additional, Goulart, Jacqueline M., additional, Grant-Kels, Jane M., additional, Guitart, Joan, additional, Hall-Jordan, Luke, additional, Halpern, Allan C., additional, Hanlon, Allison, additional, Heilman, Edward, additional, Hofmann-Wellenhof, Rainer, additional, Hufford, Drusilla, additional, Ibrahim, Sherrif F., additional, Iyer, Jayasri G., additional, Jiang, S. Brian, additional, Kanavy, Holly, additional, Kasparian, Nadine Angele, additional, Kerl, Helmut, additional, Kies, Merrill S., additional, Kirkwood, John M., additional, Kleinerman, Rebecca, additional, Kohlmann, Wendy, additional, Krathen, Michael, additional, Lacouture, Mario E., additional, Lang, Pearon G., additional, Lazar, Alexander J., additional, Leachman, Sancy, additional, LeBoit, Philip E., additional, Lebovitz, Peter J., additional, Lebwohl, Mark G., additional, Lee, Ken K., additional, Leffell, David J., additional, Leitenberger, Justin J., additional, Lim, Henry W., additional, Maize, John C., additional, Marghoob, Ashfaq A., additional, McLellan, Beth, additional, Miller, Michael K., additional, Mohan, Kriti, additional, Morton, Colin A., additional, Moschos, Stergios J., additional, Naldi, Luigi, additional, Nghiem, Paul, additional, Nino, Tanya, additional, Oganesyan, Gagik, additional, Oliviero, Margaret C., additional, Orlow, Seth J., additional, Ott, Patrick A., additional, Pandya, Amit G., additional, Pasquali, Paola, additional, Pavlick, Anna C., additional, Pilon-Thomas, Shari, additional, Polsky, David, additional, Price, Harper N., additional, Qureshi, Abrar A., additional, Rabinovitz, Harold S., additional, Requena, Luis, additional, Ricotti, Carlos, additional, Rigel, Darrell S., additional, Robert, Caroline, additional, Robinson, June K., additional, Rosen, Theodore, additional, Ross, Merrick, additional, Russak, Julie E., additional, Sacks, Justin M., additional, Sanchez, Miguel, additional, Sangueza, Omar P., additional, Santa Cruz, Daniel J., additional, Sarnaik, Amod A., additional, Schadt, Courtney R., additional, Schaffer, Julie V., additional, Scope, Alon, additional, Sobanko, Joseph F., additional, Sondak, Vernon K., additional, Spencer, James M., additional, Stasko, Thomas, additional, Stein, Jennifer, additional, Stockfleth, Eggert, additional, Strahan, Jamison, additional, Swanson, Neil A., additional, Tarhini, Ahmad, additional, Tawbi, Hussein, additional, Taylor, R. Stan, additional, Thibodeau, Renee, additional, Thiers, Bruce H., additional, Tierney, Emily, additional, Torres, Abel, additional, Tran, Kien T., additional, Upjohn, Edward, additional, Valins, Whitney Elizabeth, additional, Viera, Martha H., additional, Vohra, Nasreen, additional, Wachsman, William, additional, Walsh, Sarah N., additional, Wang, Steven Q., additional, Warner, Christina L., additional, Weinkle, Allison, additional, Weinstock, Martin A., additional, Wentzell, J. Michael, additional, Williams, Victoria, additional, Wisco, Oliver J., additional, Witmer, William K., additional, Xie, Wenfei, additional, and Zwischenberger, Brittany A., additional

Published
2011
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