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2. Subclinical hypothyroidism predicts outcome in heart failure: insights from the T.O.S.CA. registry

Author

De Luca, Mariarosaria, D’Assante, Roberta, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, De Giorgi, Alfredo, Limongelli, Giuseppe, Masarone, Daniele, Volterrani, Maurizio, Mancini, Antonio, Passantino, Andrea, Perrone Filardi, Pasquale, Sciacqua, Angela, Vriz, Olga, Castello, Roberto, Campo, Michela, Lisco, Giuseppe, Modesti, Pietro Amedeo, Paolillo, Stefania, Suzuki, Toru, Salzano, Andrea, Marra, Alberto Maria, Bossone, Eduardo, and Cittadini, Antonio

Published
2024
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3. Correction: Subclinical hypothyroidism predicts outcome in heart failure: insights from the T.O.S.CA. registry

Author

De Luca, Mariarosaria, D’Assante, Roberta, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, De Giorgi, Alfredo, Limongelli, Giuseppe, Masarone, Daniele, Volterrani, Maurizio, Mancini, Antonio, Passantino, Andrea, Perrone Filardi, Pasquale, Sciacqua, Angela, Vriz, Olga, Castello, Roberto, Campo, Michela, Lisco, Giuseppe, Modesti, Pietro Amedeo, Paolillo, Stefania, Suzuki, Toru, Salzano, Andrea, Marra, Alberto Maria, Bossone, Eduardo, and Cittadini, Antonio

Published
2024
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6. The protective effect of Bergamot Polyphenolic Fraction on reno-cardiac damage induced by DOCA-salt and unilateral renal artery ligation in rats

Author

Carresi, Cristina, Cardamone, Antonio, Coppoletta, Anna Rita, Caminiti, Rosamaria, Macrì, Roberta, Lorenzo, Francesca, Scarano, Federica, Mollace, Rocco, Guarnieri, Lorenza, Ruga, Stefano, Nucera, Saverio, Musolino, Vincenzo, Gliozzi, Micaela, Palma, Ernesto, Muscoli, Carolina, Volterrani, Maurizio, and Mollace, Vincenzo

Published
2024
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7. Left ventricular ejection fraction digit bias and reclassification of heart failure with mildly reduced vs reduced ejection fraction based on the 2021 definition and classification of heart failure

Author

Savarese, Gianluigi, Gatti, Paolo, Benson, Lina, Adamo, Marianna, Chioncel, Ovidiu, Crespo-Leiro, Maria G., Anker, Stefan D., Coats, Andrew J.S., Filippatos, Gerasimos, Lainscak, Mitja, McDonagh, Theresa, Mebazaa, Alexandre, Metra, Marco, Piepoli, Massimo F., Rosano, Giuseppe M.C., Ruschitzka, Frank, Seferovic, Petar, Volterrani, Maurizio, Maggioni, Aldo P., and Lund, Lars H.

Published
2024
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8. Insulin-like growth factor-1 (IGF-1) as predictor of cardiovascular mortality in heart failure patients: data from the T.O.S.CA. registry

Author

De Giorgi, Alfredo, Marra, Alberto Maria, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, Cacciatore, Francesco, Maiello, Ciro, Limongelli, Giuseppe, Masarone, Daniele, Perticone, Francesco, Filardi, Pasquale Perrone, Paolillo, Stefania, Mancini, Antonio, Volterrani, Maurizio, Vriz, Olga, Castello, Roberto, Passantino, Andrea, Campo, Michela, Modesti, Pietro Amedeo, Salzano, Andrea, D’Assante, Roberta, Arcopinto, Michele, Raparelli, Valeria, Fabbian, Fabio, Sciacqua, Angela, Colao, Annamaria, Suzuki, Toru, Bossone, Eduardo, and Cittadini, Antonio

Published
2022
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9. Right heart failure with left ventricular assist devices: Preoperative, perioperative and postoperative management strategies. A clinical consensus statement of the Heart Failure Association (HFA) of the ESC

Author

Adamopoulos, Stamatis, primary, Bonios, Michael, additional, Ben Gal, Tuvia, additional, Gustafsson, Finn, additional, Abdelhamid, Magdy, additional, Adamo, Marianna, additional, Bayes‐Genis, Antonio, additional, Böhm, Michael, additional, Chioncel, Ovidiu, additional, Cohen‐Solal, Alain, additional, Damman, Kevin, additional, Di Nora, Concetta, additional, Hashmani, Shahrukh, additional, Hill, Loreena, additional, Jaarsma, Tiny, additional, Jankowska, Ewa, additional, Lopatin, Yury, additional, Masetti, Marco, additional, Mehra, Mandeep R., additional, Milicic, Davor, additional, Moura, Brenda, additional, Mullens, Wilfried, additional, Nalbantgil, Sanem, additional, Panagiotou, Chrysoula, additional, Piepoli, Massimo, additional, Rakisheva, Amina, additional, Ristic, Arsen, additional, Rivinius, Rasmus, additional, Savarese, Gianluigi, additional, Thum, Thomas, additional, Tocchetti, Carlo Gabriele, additional, Tops, Laurens F., additional, Van Laake, Linda W., additional, Volterrani, Maurizio, additional, Seferovic, Petar, additional, Coats, Andrew, additional, Metra, Marco, additional, and Rosano, Giuseppe, additional

Published
2024
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10. Differences in presentation, diagnosis and management of heart failure in women. A scientific statement of the Heart Failure Association of the ESC

Author

Rosano, Giuseppe M.C., primary, Stolfo, Davide, additional, Anderson, Lisa, additional, Abdelhamid, Magdy, additional, Adamo, Marianna, additional, Bauersachs, Johann, additional, Bayes‐Genis, Antoni, additional, Böhm, Michael, additional, Chioncel, Ovidiu, additional, Filippatos, Gerasimos, additional, Hill, Loreena, additional, Lainscak, Mitja, additional, Lambrinou, Ekaterini, additional, Maas, Angela H.E.M., additional, Massouh, Angela R., additional, Moura, Brenda, additional, Petrie, Mark C., additional, Rakisheva, Amina, additional, Ray, Robin, additional, Savarese, Gianluigi, additional, Skouri, Hadi, additional, Van Linthout, Sophie, additional, Vitale, Cristiana, additional, Volterrani, Maurizio, additional, Metra, Marco, additional, and Coats, Andrew J.S., additional

Published
2024
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11. How to tackle therapeutic inertia in heart failure with reduced ejection fraction. A scientific statement of the Heart Failure Association of the ESC

Author

Savarese, Gianluigi, primary, Lindberg, Felix, additional, Cannata, Antonio, additional, Chioncel, Ovidiu, additional, Stolfo, Davide, additional, Musella, Francesca, additional, Tomasoni, Daniela, additional, Abdelhamid, Magdy, additional, Banerjee, Debasish, additional, Bayes‐Genis, Antoni, additional, Berthelot, Emmanuelle, additional, Braunschweig, Frieder, additional, Coats, Andrew J.S., additional, Girerd, Nicolas, additional, Jankowska, Ewa A., additional, Hill, Loreena, additional, Lainscak, Mitja, additional, Lopatin, Yury, additional, Lund, Lars H., additional, Maggioni, Aldo P., additional, Moura, Brenda, additional, Rakisheva, Amina, additional, Ray, Robin, additional, Seferovic, Petar M., additional, Skouri, Hadi, additional, Vitale, Cristiana, additional, Volterrani, Maurizio, additional, Metra, Marco, additional, and Rosano, Giuseppe M.C., additional

Published
2024
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12. Changes in left atrial function following two regimens of combined exercise training in patients with ischemic cardiomyopathy: a pilot study

Author

Caminiti, Giuseppe, primary, Volterrani, Maurizio, additional, Iellamo, Ferdinando, additional, Marazzi, Giuseppe, additional, Manzi, Vincenzo, additional, D’Antoni, Valentino, additional, Vadalà, Sara, additional, Di Biasio, Deborah, additional, Catena, Matteo, additional, Morsella, Valentina, additional, and Perrone, Marco Alfonso, additional

Published
2024
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13. The impact of the COVID-19 pandemic on heart failure management: Global experience of the OPTIMIZE Heart Failure Care network

Author

Cowie, Martin R., Mourilhe-Rocha, Ricardo, Chang, Hung-Yu, Volterrani, Maurizio, Ban, Ha Ngoc, Campos de Albuquerque, Denilson, Chung, Edward, Fonseca, Cândida, Lopatin, Yuri, Magaña Serrano, José Antonio, Mircheva, Lilyana, Moncada-Paz, Gustavo Adolfo, Pagava, Zurab, Reyes, Eugenio B., Saldarriaga, Clara, Schwartzmann, Pedro, Sim Kheng Leng, David, Trivi, Marcelo, Yotov, Yoto Trifonov, and Zieroth, Shelley

Published
2022
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14. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial

Author

Voors, Adriaan A., Angermann, Christiane E., Teerlink, John R., Collins, Sean P., Kosiborod, Mikhail, Biegus, Jan, Ferreira, João Pedro, Nassif, Michael E., Psotka, Mitchell A., Tromp, Jasper, Borleffs, C. Jan Willem, Ma, Changsheng, Comin-Colet, Joseph, Fu, Michael, Janssens, Stefan P., Kiss, Robert G., Mentz, Robert J., Sakata, Yasushi, Schirmer, Henrik, Schou, Morten, Schulze, P. Christian, Spinarova, Lenka, Volterrani, Maurizio, Wranicz, Jerzy K., Zeymer, Uwe, Zieroth, Shelley, Brueckmann, Martina, Blatchford, Jonathan P., Salsali, Afshin, and Ponikowski, Piotr

Published
2022
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15. Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry

Author

Salzano, Andrea, D’Assante, Roberta, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, Cacciatore, Francesco, Maiello, Ciro, Limongelli, Giuseppe, Masarone, Daniele, Sciacqua, Angela, Filardi, Pasquale Perrone, Mancini, Antonio, Volterrani, Maurizio, Vriz, Olga, Castello, Roberto, Passantino, Andrea, Campo, Michela, Modesti, Pietro A., De Giorgi, Alfredo, Arcopinto, Michele, Gargiulo, Paola, Perticone, Maria, Colao, Annamaria, Milano, Salvatore, Garavaglia, Agnese, Napoli, Raffaele, Suzuki, Toru, Bossone, Eduardo, Marra, Alberto M., and Cittadini, Antonio

Published
2022
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16. New Therapeutics for Heart Failure Worsening: Focus on Vericiguat.

Author

Russo, Patrizia, Vitiello, Laura, Milani, Francesca, Volterrani, Maurizio, Rosano, Giuseppe M. C., Tomino, Carlo, and Bonassi, Stefano

Subjects
SECOND messengers (Biochemistry), NATRIURETIC peptides, ACE inhibitors, GUANYLATE cyclase, CARDIOVASCULAR system, HEART failure
Abstract

Heart failure (HF) is a syndrome characterized by signs and symptoms resulting from structural or functional cardiac abnormalities, confirmed by elevated natriuretic peptides or evidence of congestion. HF patients are classified according to left ventricular ejection fraction (LVEF). Worsening HF (WHF) is associated with increased short- and long-term mortality, re-hospitalization, and healthcare costs. The standard treatment of HF includes angiotensin-converting enzyme inhibitors, angiotensin receptor–neprilysin inhibitors, mineralocorticoid-receptor antagonists, beta-blockers, and sodium-glucose-co-transporter 2 inhibitors. To manage systolic HF by reducing mortality and hospitalizations in patients experiencing WHF, treatment with vericiguat, a direct stimulator of soluble guanylate cyclase (sGC), is indicated. This drug acts by stimulating sGC enzymes, part of the nitric oxide (NO)–sGC–cyclic guanosine monophosphate (cGMP) signaling pathway, regulating the cardiovascular system by catalyzing cGMP synthesis in response to NO. cGMP acts as a second messenger, triggering various cellular effects. Deficiencies in cGMP production, often due to low NO availability, are implicated in cardiovascular diseases. Vericiguat stimulates sGC directly, bypassing the need for a functional NO-sGC-cGMP axis, thus preventing myocardial and vascular dysfunction associated with decreased sGC activity in heart failure. Approved by the FDA in 2021, vericiguat administration should be considered, in addition to the four pillars of reduced EF (HFrEF) therapy, in symptomatic patients with LVEF < 45% following a worsening event. Cardiac rehabilitation represents an ideal setting where there is more time to implement therapy with vericiguat and incorporate a greater number of medications for the management of these patients. This review covers vericiguat's metabolism, molecular mechanisms, and drug–drug interactions. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Prevention and Rehabilitation After Heart Transplantation: A Clinical Consensus Statement of the European Association of Preventive Cardiology, Heart Failure Association of the ESC, and the European Cardio Thoracic Transplant Association, a Section of ESOT

Author

Simonenko, Maria, Hansen, Dominique, Niebauer, Josef, Volterrani, Maurizio, Adamopoulos, Stamatis, Amarelli, Cristiano, Ambrosetti, Marco, Anker, Stefan D., Bayes-Genis, Antonio, Gal, Tuvia Ben, Bowen, T. Scott, Cacciatore, Francesco, Caminiti, Giuseppe, Cavarretta, Elena, Chioncel, Ovidiu, Coats, Andrew J. S., Cohen-Solal, Alain, D'Ascenzi, Flavio, de Pablo Zarzosa, Carmen, and Gevaert, Andreas B.

Subjects
HEART transplantation, HEART failure, ARTIFICIAL blood circulation, HEART failure patients, REHABILITATION
Abstract

Little is known either about either physical activity patterns, or other lifestyle-related prevention measures in heart transplantation (HTx) recipients. The history of HTx started more than 50 years ago but there are still no guidelines or position papers highlighting the features of prevention and rehabilitation after HTx. The aims of this scientific statement are (i) to explain the importance of prevention and rehabilitation after HTx, and (ii) to promote the factors (modifiable/non-modifiable) that should be addressed after HTx to improve patients' physical capacity, quality of life and survival. All HTx team members have their role to play in the care of these patients and multidisciplinary prevention and rehabilitation programmes designed for transplant recipients. HTx recipients are clearly not healthy disease-free subjects yet they also significantly differ from heart failure patients or those who are supported with mechanical circulatory support. Therefore, prevention and rehabilitation after HTx both need to be specifically tailored to this patient population and be multidisciplinary in nature. Prevention and rehabilitation programmes should be initiated early after HTx and continued during the entire post-transplant journey. This clinical consensus statement focuses on the importance and the characteristics of prevention and rehabilitation designed for HTx recipients. [ABSTRACT FROM AUTHOR]

Published
2024
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18. The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension

Author

Caminiti, Rosamaria, primary, Carresi, Cristina, additional, Mollace, Rocco, additional, Macrì, Roberta, additional, Scarano, Federica, additional, Oppedisano, Francesca, additional, Maiuolo, Jessica, additional, Serra, Maria, additional, Ruga, Stefano, additional, Nucera, Saverio, additional, Tavernese, Annamaria, additional, Gliozzi, Micaela, additional, Musolino, Vincenzo, additional, Palma, Ernesto, additional, Muscoli, Carolina, additional, Rubattu, Speranza, additional, Volterrani, Maurizio, additional, Federici, Massimo, additional, Volpe, Massimo, additional, and Mollace, Vincenzo, additional

Published
2024
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19. Pulmonary embolism in patients with COVID-19: characteristics and outcomes in the Cardio-COVID Italy multicenter study

Author

Ameri, Pietro, Inciardi, Riccardo M., Di Pasquale, Mattia, Agostoni, Piergiuseppe, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Danzi, Giambattista, Dalla Vecchia, Laura, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Anita, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Sinagra, Gianfranco, Tedino, Chiara, Tomasoni, Daniela, Volterrani, Maurizio, Zaccone, Gregorio, Lombardi, Carlo Mario, Senni, Michele, and Metra, Marco

Published
2021
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20. Machine learning for prediction of in-hospital mortality in coronavirus disease 2019 patients: results from an Italian multicenter study

Author

Vezzoli, Marika, Inciardi, Riccardo Maria, Oriecuia, Chiara, Paris, Sara, Murillo, Natalia Herrera, Agostoni, Piergiuseppe, Ameri, Pietro, Bellasi, Antonio, Camporotondo, Rita, Canale, Claudia, Carubelli, Valentina, Carugo, Stefano, Catagnano, Francesco, Danzi, Giambattista, Dalla Vecchia, Laura, Giovinazzo, Stefano, Gnecchi, Massimiliano, Guazzi, Marco, Iorio, Anita, La Rovere, Maria Teresa, Leonardi, Sergio, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Merlo, Marco, Monzo, Luca, Mortara, Andrea, Nuzzi, Vincenzo, Pagnesi, Matteo, Piepoli, Massimo, Porto, Italo, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Senni, Michele, Sinagra, Gianfranco, Tomasoni, Daniela, Adamo, Marianna, Volterrani, Maurizio, Maroldi, Roberto, Metra, Marco, Lombardi, Carlo Mario, and Specchia, Claudia

Published
2022
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21. Sex-related differences in patients with coronavirus disease 2019: results of the Cardio-COVID-Italy multicentre study

Author

Lombardi, Carlo Mario, Specchia, Claudia, Conforti, Fabio, Rovere, Maria Teresa La, Carubelli, Valentina, Agostoni, Piergiuseppe, Carugo, Stefano, Danzi, Gian Battista, Guazzi, Marco, Mortara, Andrea, Piepoli, Massimo, Porto, Italo, Sinagra, Gianfranco, Volterrani, Maurizio, Ameri, Pietro, Gnecchi, Massimiliano, Leonardi, Sergio, Merlo, Marco, Iorio, Annamaria, Bellasi, Antonio, Canale, Claudia, Camporotondo, Rita, Catagnano, Francesco, Dalla Vecchia, Laura Adelaide, Di Pasquale, Mattia, Giovinazzo, Stefano, Maccagni, Gloria, Mapelli, Massimo, Margonato, Davide, Monzo, Luca, Nuzzi, Vincenzo, Oriecuia, Chiara, Pala, Laura, Peveri, Giulia, Pozzi, Andrea, Provenzale, Giovanni, Sarullo, Filippo, Adamo, Marianna, Tomasoni, Daniela, Inciardi, Riccardo Maria, Senni, Michele, and Metra, Marco

Published
2022
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22. The synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular inflammation and oxidative stress in non-alcoholic fatty liver disease

Author

Musolino, Vincenzo, Gliozzi, Micaela, Bombardelli, Ezio, Nucera, Saverio, Carresi, Cristina, Maiuolo, Jessica, Mollace, Rocco, Paone, Sara, Bosco, Francesca, Scarano, Federica, Scicchitano, Miriam, Macrì, Roberta, Ruga, Stefano, Zito, Maria Caterina, Palma, Ernesto, Gratteri, Santo, Ragusa, Monica, Volterrani, Maurizio, Fini, Massimo, and Mollace, Vincenzo

Published
2020
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23. Incidence, risk assessment and prevention of sudden cardiac death in cardiomyopathies

Author

Polovina, Marija, primary, Tschöpe, Carsten, additional, Rosano, Giuseppe, additional, Metra, Marco, additional, Crea, Filippo, additional, Mullens, Wilfried, additional, Bauersachs, Johann, additional, Sliwa, Karen, additional, de Boer, Rudolf A., additional, Farmakis, Dimitrios, additional, Thum, Thomas, additional, Corrado, Domenico, additional, Bayes‐Genis, Antoni, additional, Bozkurt, Biykem, additional, Filippatos, Gerasimos, additional, Keren, Andre, additional, Skouri, Hadi, additional, Moura, Brenda, additional, Volterrani, Maurizio, additional, Abdelhamid, Magdy, additional, Ašanin, Milika, additional, Krljanac, Gordana, additional, Tomić, Milenko, additional, Savarese, Gianluigi, additional, Adamo, Marianna, additional, Lopatin, Yuri, additional, Chioncel, Ovidiu, additional, Coats, Andrew J.S., additional, and Seferović, Petar M., additional

Published
2023
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24. LEFT VENTRICULAR EJECTION FRACTION DIGIT BIAS AND RECLASSIFICATION OF HEART FAILURE WITH MILDLY REDUCED VS. REDUCED EJECTION FRACTION BASED ON THE 2021 DEFINITION AND CLASSIFICATION OF HEART FAILURE

Author

Savarese, Gianluigi, primary, Gatti, Paolo, additional, Benson, Lina, additional, Adamo, Marianna, additional, Chioncel, Ovidiu, additional, Crespo-Leiro, Maria G., additional, Anker, Stefan D., additional, Coats, Andrew J.S., additional, Filippatos, Gerasimos, additional, Lainscak, Mitja, additional, McDonagh, Theresa, additional, Mebazaa, Alexandre, additional, Metra, Marco, additional, Piepoli, Massimo F., additional, Rosano, Giuseppe M.C., additional, Ruschitzka, Frank, additional, Seferovic, Petar, additional, Volterrani, Maurizio, additional, Maggioni, Aldo P., additional, and und, Lars, additional

Published
2023
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26. A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial).

Author

Anker, Stefan, Coats, Andrew, Cristian, Gabriel, Dragomir, Dinu, Pusineri, Enrico, Piredda, Massimo, Bettari, Luca, Dowling, Robert, Volterrani, Maurizio, Kirwan, Bridget-Anne, Filippatos, Gerasimos, Mas, Jean-Louis, Danchin, Nicolas, Solomon, Scott, Ahmann, Frank, Hinson, Andy, Sabbah, Hani, Mann, Douglas, and Lee, Randall

Subjects
Advanced chronic heart failure, Alginate-hydrogel, Exercise capacity, Safety, Symptoms, Alginates, Echocardiography, Exercise Test, Exercise Tolerance, Female, Glucuronic Acid, Heart Failure, Hexuronic Acids, Humans, Hydrogel, Polyethylene Glycol Dimethacrylate, Length of Stay, Male, Middle Aged, Oxygen Consumption, Patient Safety, Prospective Studies, Prostheses and Implants, Quality of Life, Treatment Outcome, Walking
Abstract

AIMS: AUGMENT-HF was an international, multi-centre, prospective, randomized, controlled trial to evaluate the benefits and safety of a novel method of left ventricular (LV) modification with alginate-hydrogel. METHODS: Alginate-hydrogel is an inert permanent implant that is directly injected into LV heart muscle and serves as a prosthetic scaffold to modify the shape and size of the dilated LV. Patients with advanced chronic heart failure (HF) were randomized (1 : 1) to alginate-hydrogel (n = 40) in combination with standard medical therapy or standard medical therapy alone (Control, n = 38). The primary endpoint of AUGMENT-HF was the change in peak VO2 from baseline to 6 months. Secondary endpoints included changes in 6-min walk test (6MWT) distance and New York Heart Association (NYHA) functional class, as well as assessments of procedural safety. RESULTS: Enrolled patients were 63 ± 10 years old, 74% in NYHA functional class III, had a LV ejection fraction of 26 ± 5% and a mean peak VO2 of 12.2 ± 1.8 mL/kg/min. Thirty-five patients were successfully treated with alginate-hydrogel injections through a limited left thoracotomy approach without device-related complications; the 30-day surgical mortality was 8.6% (3 deaths). Alginate-hydrogel treatment was associated with improved peak VO2 at 6 months-treatment effect vs. CONTROL: +1.24 mL/kg/min (95% confidence interval 0.26-2.23, P = 0.014). Also 6MWT distance and NYHA functional class improved in alginate-hydrogel-treated patients vs. Control (both P < 0.001). CONCLUSION: Alginate-hydrogel in addition to standard medical therapy for patients with advanced chronic HF was more effective than standard medical therapy alone for improving exercise capacity and symptoms. The results of AUGMENT-HF provide proof of concept for a pivotal trial. TRIAL REGISTRATION NUMBER: NCT01311791.

Published
2015

28. State‐of‐the‐art document on optimal contemporary management of cardiomyopathies

Author

Seferović, Petar M., primary, Polovina, Marija, additional, Rosano, Giuseppe, additional, Bozkurt, Biykem, additional, Metra, Marco, additional, Heymans, Stephane, additional, Mullens, Wilfried, additional, Bauersachs, Johann, additional, Sliwa, Karen, additional, de Boer, Rudolf A., additional, Farmakis, Dimitrios, additional, Thum, Thomas, additional, Olivotto, Iacopo, additional, Rapezzi, Claudio, additional, Linhart, Aleš, additional, Corrado, Domenico, additional, Tschöpe, Carsten, additional, Milinković, Ivan, additional, Bayes Genis, Antoni, additional, Filippatos, Gerasimos, additional, Keren, Andre, additional, Ašanin, Milika, additional, Krljanac, Gordana, additional, Maksimović, Ružica, additional, Skouri, Hadi, additional, Ben Gal, Tuvia, additional, Moura, Brenda, additional, Volterrani, Maurizio, additional, Abdelhamid, Magdy, additional, Lopatin, Yuri, additional, Chioncel, Ovidiu, additional, and Coats, Andrew J.S., additional

Published
2023
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29. Practical Algorithms for Early Diagnosis of Heart Failure and Heart Stress using NT‐proBNP: A Clinical Consensus Statement from the Heart Failure Association of the ESC

Author

Bayes‐Genis, Antoni, primary, Doherty, Kieran F, additional, Petrie, Mark C, additional, Januzzi, James L, additional, Mueller, Christian, additional, Andreson, Lisa, additional, Bozkurt, Biykem, additional, Butler, Javed, additional, Chioncel, Ovidiu, additional, Cleland, John GF, additional, Christodorescu, Ruxandra, additional, Del Prato, Stefano, additional, Gustafsson, Finn, additional, Lam, Carolyn S.P., additional, Moura, Brenda, additional, Pop‐Busui, Rodica, additional, Seferovic, Petar, additional, Volterrani, Maurizio, additional, Vaduganathan, Muthiah, additional, Metra, Marco, additional, and Rosano, Giuseppe, additional

Published
2023
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30. Acute Changes on Left Atrial Function during Incremental Exercise in Patients with Heart Failure with Mildly Reduced Ejection Fraction: A Case-Control Study

Author

Perrone, Marco Alfonso, primary, Iellamo, Ferdinando, additional, D’Antoni, Valentino, additional, Gismondi, Alessandro, additional, Di Biasio, Deborah, additional, Vadalà, Sara, additional, Marazzi, Giuseppe, additional, Morsella, Valentina, additional, Volterrani, Maurizio, additional, and Caminiti, Giuseppe, additional

Published
2023
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31. Patient phenotype profiling in heart failure with preserved ejection fraction to guide therapeutic decision making. A scientific statement of the Heart Failure Association, the European Heart Rhythm Association of the European Society of Cardiology, and the European Society of Hypertension

Author

Anker, Stefan D., primary, Usman, Muhammad Shariq, additional, Anker, Markus S., additional, Butler, Javed, additional, Böhm, Michael, additional, Abraham, William T., additional, Adamo, Marianna, additional, Chopra, Vijay K., additional, Cicoira, Mariantonietta, additional, Cosentino, Francesco, additional, Filippatos, Gerasimos, additional, Jankowska, Ewa A., additional, Lund, Lars H., additional, Moura, Brenda, additional, Mullens, Wilfried, additional, Pieske, Burkert, additional, Ponikowski, Piotr, additional, Gonzalez‐Juanatey, Jose R., additional, Rakisheva, Amina, additional, Savarese, Gianluigi, additional, Seferovic, Petar, additional, Teerlink, John R., additional, Tschöpe, Carsten, additional, Volterrani, Maurizio, additional, von Haehling, Stephan, additional, Zhang, Jian, additional, Zhang, Yuhui, additional, Bauersachs, Johann, additional, Landmesser, Ulf, additional, Zieroth, Shelley, additional, Tsioufis, Konstantinos, additional, Bayes‐Genis, Antoni, additional, Chioncel, Ovidiu, additional, Andreotti, Felicita, additional, Agabiti‐Rosei, Enrico, additional, Merino, Jose L., additional, Metra, Marco, additional, Coats, Andrew J.S., additional, and Rosano, Giuseppe M.C., additional

Published
2023
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32. Rationale and design of the CV-PREVITAL study: an Italian multiple cohort randomised controlled trial investigating innovative digital strategies in primary cardiovascular prevention

Author

Baldassarre, Damiano, primary, Iacoviello, Licia, additional, Baetta, Roberta, additional, Roncaglioni, Maria Carla, additional, Condorelli, Gianluigi, additional, Remuzzi, Giuseppe, additional, Gensini, Gianfranco, additional, Frati, Luigi, additional, Ricciardi, Walter, additional, Conaldi, Pier Giulio, additional, Uccelli, Antonio, additional, Blandini, Fabio, additional, Bosari, Silvano, additional, Scambia, Giovanni, additional, Fini, Massimo, additional, Di Malta, Antonio, additional, Amato, Mauro, additional, Veglia, Fabrizio, additional, Bonomi, Alice, additional, Klersy, Catherine, additional, Colazzo, Francesca, additional, Pengo, Martino, additional, Gorini, Francesca, additional, Auteri, Luciana, additional, Ferrante, Giuseppe, additional, Baviera, Marta, additional, Ambrosio, Giuseppe, additional, Catapano, Alberico, additional, Gialluisi, Alessandro, additional, Malavazos, Alexis Elias, additional, Castelvecchio, Serenella, additional, Corsi-Romanelli, Massimiliano Marco, additional, Cardani, Rosanna, additional, Rovere, Maria Teresa La, additional, Agnese, Valentina, additional, Pane, Bianca, additional, Prati, Daniele, additional, Spinardi, Laura, additional, Liuzzo, Giovanna, additional, Arbustini, Eloisa, additional, Volterrani, Maurizio, additional, Visconti, Marco, additional, Werba, José Pablo, additional, Genovese, Stefano, additional, Bilo, Grzegorz, additional, Invitti, Cecilia, additional, Di Blasio, Anna, additional, Lombardi, Carolina, additional, Faini, Andrea, additional, Rosa, Debora, additional, Ojeda-Fernández, Luisa, additional, Foresta, Andreana, additional, De Curtis, Amalia, additional, Di Castelnuovo, Augusto, additional, Scalvini, Simonetta, additional, Pierobon, Antonia, additional, Gorini, Alessandra, additional, Valenti, Luca, additional, Luzi, Livio, additional, Racca, Annarosa, additional, Bandi, Manuela, additional, Tremoli, Elena, additional, Menicanti, Lorenzo, additional, Parati, Gianfranco, additional, and Pompilio, Giulio, additional

Published
2023
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34. Worsening of chronic heart failure: definition, epidemiology, management and prevention. A clinical consensus statement by the Heart Failure Association of the European Society of Cardiology

Author

Metra, Marco, Tomasoni, Daniela, Adamo, Marianna, Bayes-Genis, Antoni, Filippatos, Gerasimos, Abdelhamid, Magdy, Adamopoulos, Stamatis, Anker, Stefan D, Antohi, Laura, Böhm, Michael, Braunschweig, Frieder, Gal, Tuvia Ben, Butler, Javed, Cleland, John G F, Cohen-Solal, Alain, Damman, Kevin, Gustafsson, Finn, Hill, Loreena, Jankowska, Ewa A, Lainscak, Mitja, Lund, Lars H, McDonagh, Theresa, Mebazaa, Alexandre, Moura, Brenda, Mullens, Wilfried, Piepoli, Massimo, Ponikowski, Piotr, Rakisheva, Amina, Ristic, Arsen, Savarese, Gianluigi, Seferovic, Petar, Sharma, Rajan, Tocchetti, Carlo Gabriele, Yılmaz, Mehmet Birhan, Vitale, Cristiana, Volterrani, Maurizio, von Haehling, Stephan, Chioncel, Ovidiu, Coats, Andrew J S, Rosano, Giuseppe, Metra, Marco, Tomasoni, Daniela, Adamo, Marianna, Bayes-Genis, Antoni, Filippatos, Gerasimo, Abdelhamid, Magdy, Adamopoulos, Stamati, Anker, Stefan D, Antohi, Laura, Böhm, Michael, Braunschweig, Frieder, Gal, Tuvia Ben, Butler, Javed, Cleland, John G F, Cohen-Solal, Alain, Damman, Kevin, Gustafsson, Finn, Hill, Loreena, Jankowska, Ewa A, Lainscak, Mitja, Lund, Lars H, Mcdonagh, Theresa, Mebazaa, Alexandre, Moura, Brenda, Mullens, Wilfried, Piepoli, Massimo, Ponikowski, Piotr, Rakisheva, Amina, Ristic, Arsen, Savarese, Gianluigi, Seferovic, Petar, Sharma, Rajan, Tocchetti, Carlo Gabriele, Yılmaz, Mehmet Birhan, Vitale, Cristiana, Volterrani, Maurizio, von Haehling, Stephan, Chioncel, Ovidiu, Coats, Andrew J S, and Rosano, Giuseppe

Subjects
Hospitalization, Emergency department visits, Intensification of oral therapy, Outpatients, Prognosis, Worsening heart failure, Prognosi, Outpatient, Emergency department visit, Cardiology and Cardiovascular Medicine
Abstract

Episodes of worsening symptoms and signs characterize the clinical course of patients with chronic heart failure (HF). These events are associated with poorer quality of life, increased risks of hospitalization and death and are a major burden on healthcare resources. They usually require diuretic therapy, either administered intravenously or by escalation of oral doses or with combinations of different diuretic classes. Additional treatments may also have a major role, including initiation of guideline-recommended medical therapy (GRMT). Hospital admission is often necessary but treatment in the emergency service or in outpatient clinics or by primary care physicians has become increasingly used. Prevention of first and recurring episodes of worsening HF is an essential component of HF treatment and this may be achieved through early and rapid administration of GRMT. The aim of the present clinical consensus statement by the Heart Failure Association of the European Society of Cardiology is to provide an update on the definition, clinical characteristics, management and prevention of worsening HF in clinical practice.

Published
2023

35. Optimizing outcomes in heart failure: 2022 and beyond

Author

Jankowska, Ewa A., Andersson, Tomas, Kaiser-Albers, Claudia, Bozkurt, Biykem, Chioncel, Ovidiu, Coats, Andrew J. S., Hill, Loreena, Koehler, Friedrich, Lund, Lars H., McDonagh, Theresa, Metra, Marco, Mittmann, Clemens, MULLENS, Wilfried, Siebert, Uwe, Solomon, Scott D., Volterrani, Maurizio, McMurray, John J. V., Jankowska, Ewa A., Andersson, Tomas, Kaiser-Albers, Claudia, Bozkurt, Biykem, Chioncel, Ovidiu, Coats, Andrew J. S., Hill, Loreena, Koehler, Friedrich, Lund, Lars H., McDonagh, Theresa, Metra, Marco, Mittmann, Clemens, MULLENS, Wilfried, Siebert, Uwe, Solomon, Scott D., Volterrani, Maurizio, and McMurray, John J. V.

Subjects
Multidisciplinary management, Heart failure, Medical decision making, Quality improvement, Health technology assessment, Clinical practice guidelines, Pharmacotherapy
Abstract

Although the development of therapies and tools for the improved management of heart failure (HF) continues apace, day-to-day management in clinical practice is often far from ideal. A Cardiovascular Round Table workshop was convened by the European Society of Cardiology (ESC) to identify barriers to the optimal implementation of therapies and guidelines and to consider mitigation strategies to improve patient outcomes in the future. Key challenges identified included the complexity of HF itself and its treatment, financial constraints and the perception of HF treatments as costly, failure to meet the needs of patients, suboptimal outpatient management, and the fragmented nature of healthcare systems. It was discussed that ongoing initiatives may help to address some of these barriers, such as changes incorporated into the 2021 ESC HF guideline, ESC Heart Failure Association quality indicators, quality improvement registries (e.g. EuroHeart), new ESC guidelines for patients, and the universal definition of HF. Additional priority action points discussed to promote further improvements included revised definitions of HF 'phenotypes' based on trial data, the development of implementation strategies, improved affordability, greater regulator/payer involvement, increased patient education, further development of patient-reported outcomes, better incorporation of guidelines into primary care systems, and targeted education for primary care practitioners. Finally, it was concluded that overarching changes are needed to improve current HF care models, such as the development of a standardized pathway, with a common adaptable digital backbone, decision-making support, and data integration, to ensure that the model 'learns' as the management of HF continues to evolve. This article was generated from discussions during a Cardiovascular Round Table workshop organized in September 2021 by the ESC. The ESC Cardiovascular Round Table is a strategic forum for high-level dialogue between 20 industry companies (pharmaceutical, devices, and diagnostics) and the ESC leadership to identify and discuss key strategic issues for the future of cardiovascular health in Europe. The authors would like to thank Emma Marshman [unaffiliated, supported by the European Society of Cardiology (ESC)] for assistance writing and editing the manuscript

Published
2023

36. The Improvement of Left Atrial Function after Twelve Weeks of Supervised Concurrent Training in Patients with Heart Failure with Mid-Range Ejection Fraction: A Pilot Study

Author

Caminiti, Giuseppe, primary, Perrone, Marco Alfonso, additional, D’Antoni, Valentino, additional, Marazzi, Giuseppe, additional, Gismondi, Alessandro, additional, Vadalà, Sara, additional, Di Biasio, Deborah, additional, Manzi, Vincenzo, additional, Iellamo, Ferdinando, additional, and Volterrani, Maurizio, additional

Published
2023
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37. Prevalence, clinical characteristics and outcomes of heart failure patients with or without isolated or combined mitral and tricuspid regurgitation: An analysis from the ESC‐HFA Heart Failure Long‐Term Registry

Author

Adamo, Marianna, primary, Chioncel, Ovidiu, additional, Benson, Lina, additional, Shahim, Bahira, additional, Crespo‐Leiro, Maria G., additional, Anker, Stefan D., additional, Coats, Andrew J.S., additional, Filippatos, Gerasimos, additional, Lainscak, Mitja, additional, McDonagh, Theresa, additional, Mebazaa, Alexander, additional, Piepoli, Massimo F., additional, Rosano, Giuseppe M.C., additional, Ruschitzka, Frank, additional, Savarese, Gianluigi, additional, Seferovic, Petar, additional, Shahim, Angiza, additional, Popescu, Bogdan A., additional, Iung, Bernard, additional, Volterrani, Maurizio, additional, Maggioni, Aldo P., additional, Metra, Marco, additional, and Lund, Lars H., additional

Published
2023
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38. Acute changes on atrial function during progressive exercise in patients with heart failure with mildly-reduced ejection fraction. A case-control study

Author

Iellamo, Ferdinando, primary, Caminiti, Giuseppe, additional, Perrone, Marco Alfonso, additional, D'Antoni, Valentino, additional, Gismondi, Alessandro, additional, Di Biasio, Deborah, additional, Vadala, Sara, additional, Marazzi, Giuseppe, additional, Morsella, Valentina, additional, and Volterrani, Maurizio, additional

Published
2023
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39. International validation of the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score in heart failure

Author

Adamopoulos, Stamatis, primary, Miliopoulos, Dimitris, additional, Piotrowicz, Ewa, additional, Snoek, Johan Aernout, additional, Panagopoulou, Niki, additional, Nanas, Serafim, additional, Niederseer, David, additional, Mazaheri, Reza, additional, Ma, Jing, additional, Chen, Yundai, additional, Popovic, Dejana, additional, Seferovic, Petar, additional, Girola, Davide, additional, Corrà, Ugo, additional, Coats, Andrew J S, additional, Metra, Marco, additional, Rosano, Giuseppe M C, additional, Volterrani, Maurizio, additional, Apostolo, Anna, additional, Campodonico, Jeness, additional, Salvioni, Elisabetta, additional, Agostoni, Piergiuseppe, additional, and Piepoli, Massimo, additional

Published
2023
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40. Prevalence, Characteristics and Prognostic Impact of Aortic Valve Disease in Patients with Heart Failure and Reduced, Mildly Reduced, and Preserved Ejection Fraction: An Analysis of the ESC Heart Failure Long‐Term Registry

Author

Shahim, Bahira, primary, Shahim, Angiza, additional, Adamo, Marianna, additional, Chioncel, Ovidiu, additional, Benson, Lina, additional, Shahim, Bahira, additional, Crespo‐Leiro, Maria G., additional, Anker, Stefan D., additional, Coats, Andrew J.S., additional, Filippatos, Gerasimos, additional, Lainscak, Mitja, additional, McDonagh, Theresa, additional, Mebazaa, Alexandre, additional, Piepoli, Massimo F., additional, Rosano, Giuseppe M.C., additional, Ruschitzka, Frank, additional, Savarese, Gianluigi, additional, Seferovic, Petar, additional, Volterrani, Maurizio, additional, Leiro, Marisa Crespo, additional, Cubero, Javier Segovia, additional, Amir, Offer, additional, Palic, Benjamin, additional, Maggioni, Aldo P., additional, Metra, Marco, additional, and Lund, Lars H., additional

Published
2023
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41. Pre‐discharge and early post‐discharge management of patients hospitalized for acute heart failure: a scientific statement by the Heart Failure Association ( HFA ) of the ESC

Author

Metra, Marco, primary, Adamo, Marianna, additional, Tomasoni, Daniela, additional, Mebazaa, Alexandre, additional, Bayes‐Genis, Antoni, additional, Abdelhamid, Magdy, additional, Adamopoulos, Stamatis, additional, Anker, Stefan D., additional, Bauersachs, Johann, additional, Belenkov, Yuri, additional, Böhm, Michael, additional, Gal, Tuvia Ben, additional, Butler, Javed, additional, Cohen‐Solal, Alain, additional, Filippatos, Gerasimos, additional, Gustafsson, Finn, additional, Hill, Loreena, additional, Jaarsma, Tiny, additional, Jankowska, Ewa A., additional, Lainscak, Mitja, additional, Lopatin, Yuri, additional, Lund, Lars, additional, McDonagh, Theresa, additional, Milicic, Davor, additional, Moura, Brenda, additional, Mullens, Wilfried, additional, Piepoli, Massimo, additional, Polovina, Marija, additional, Ponikowski, Piotr, additional, Rakisheva, Amina, additional, Ristic, Arsen, additional, Savarese, Gianluigi, additional, Seferovic, Petar, additional, Sharma, Rajan, additional, Thum, Thomas, additional, Tocchetti, Carlo G., additional, Van Linthout, Sophie, additional, Vitale, Cristiana, additional, Von Haehling, Stephan, additional, Volterrani, Maurizio, additional, Coats, Andrew JS, additional, Chioncel, Ovidiu, additional, and Rosano, Giuseppe, additional

Published
2023
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42. Comprehensive Characterization of Non-Cardiac Comorbidities in Acute Heart Failure- an analysis of ESC-HFA EORP Heart Failure Long-Term Registry

Author

Chioncel, Ovidiu, primary, Benson, Lina, additional, Crespo-Leiro, Maria G, additional, Anker, Stefan D, additional, Coats, Andrew J S, additional, Filippatos, Gerasimos, additional, McDonagh, Theresa, additional, Margineanu, Cornelia, additional, Mebazaa, Alexandre, additional, Metra, Marco, additional, Piepoli, Massimo F, additional, Adamo, Marianna, additional, Rosano, Giuseppe M C, additional, Ruschitzka, Frank, additional, Savarese, Gianluigi, additional, Seferovic, Petar, additional, Volterrani, Maurizio, additional, Ferrari, Roberto, additional, Maggioni, Aldo P, additional, and Lund, Lars H, additional

Published
2023
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43. Improvement of Left Atrial Function after Twelve-Weeks of Supervised Concurrent Training in Patients with Heart Failure with Mid-Range Ejection Fraction: A Pilot Study

Author

Caminiti, Giuseppe, primary, Iellamo, Ferdinando, additional, Perrone, Marco Alfonso, additional, D'Antoni, Valentino, additional, Gismondi, Alessandro, additional, Marazzi, Giuseppe, additional, Vadala, Sara, additional, Di Biasio, Deborah, additional, Manzi, Vincenzo, additional, and Volterrani, Maurizio, additional

Published
2023
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45. Worsening of chronic heart failure: definition, epidemiology, management and prevention. A clinical consensus statement by the Heart Failure Association ( HFA ) of the ESC

Author

Metra, Marco, primary, Tomasoni, Daniela, additional, Adamo, Marianna, additional, Bayes‐Genis, Antoni, additional, Filippatos, Gerasimos, additional, Abdelhamid, Magdy, additional, Adamopoulos, Stamatis, additional, Anker, Stefan D., additional, Antohi, Laura, additional, Böhm, Michael, additional, Braunschweig, Frieder, additional, Gal, Tuvia Ben, additional, Butler, Javed, additional, Cleland, John G.F., additional, Cohen‐Solal, Alain, additional, Damman, Kevin, additional, Gustafsson, Finn, additional, Hill, Loreena, additional, Jankowska, Ewa, additional, Lainscak, Mitja, additional, Lund, Lars H., additional, McDonagh, Theresa, additional, Mebazaa, Alexandre, additional, Moura, Brenda, additional, Mullens, Wilfried, additional, Piepoli, Massimo, additional, Ponikowski, Piotr, additional, Rakisheva, Amina, additional, Ristic, Arsen, additional, Savarese, Gianluigi, additional, Seferovic, Petar, additional, Sharma, Rajan, additional, Tocchetti, Carlo Gabriele, additional, Yılmaz, Mehmet Birhan, additional, Vitale, Cristiana, additional, Volterrani, Maurizio, additional, Von Haehling, Stephan, additional, Chioncel, Ovidiu, additional, Coats, Andrew JS, additional, and Rosano, Giuseppe, additional

Published
2023
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47. Optimizing outcomes in heart failure: 2022 and beyond

Author

Jankowska, Ewa A., primary, Andersson, Tomas, additional, Kaiser‐Albers, Claudia, additional, Bozkurt, Biykem, additional, Chioncel, Ovidiu, additional, Coats, Andrew J.S., additional, Hill, Loreena, additional, Koehler, Friedrich, additional, Lund, Lars H., additional, McDonagh, Theresa, additional, Metra, Marco, additional, Mittmann, Clemens, additional, Mullens, Wilfried, additional, Siebert, Uwe, additional, Solomon, Scott D., additional, Volterrani, Maurizio, additional, and McMurray, John J.V., additional

Published
2023
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