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5. List of contributors

Author

Abe, Masashi, primary, Ahlstrom, Jon D., additional, Albon, Julie, additional, Allickson, Julie, additional, Almeida-Porada, Graça, additional, Altschuler, Richard A., additional, Anderson, Daniel G., additional, Annabi, Nasim, additional, Arcidiacono, Judith, additional, Ashammakhi, Nureddin, additional, Atala, Anthony, additional, Athanasiou, Kyriacos A., additional, Awad, Hani A., additional, Badylak, Stephen F, additional, Balachander, Gowri, additional, Balkan, Wayne, additional, Bara, Jennifer J., additional, Barry, Michael P., additional, Baskaran, Harihara, additional, Bedell, Matthew L., additional, Belcher, Donald Andrew, additional, Berry, David B., additional, Bhat, Hina, additional, Bhat, Zuhaib F., additional, Bhatia, Sangeeta N., additional, Blackburn, Catherine Clare, additional, Blocki, Anna, additional, Blum, Kevin M., additional, Bochenek, Matthew A., additional, Bonassar, Lawrence J., additional, Bonventre, Joseph V., additional, Borrelli, Mimi R., additional, Bowles, Robby D., additional, Bradshaw, Amy D., additional, Bratt-Leal, Andres M., additional, Breuer, Christopher K., additional, Brewster, Luke, additional, Brey, Eric M., additional, Briquez, Priscilla S., additional, Buckwalter, J.A., additional, Burg, Karen J.L., additional, Burg, Timothy C., additional, Byambaa, Batzaya, additional, Chandra, Prafulla K., additional, Chen, Amanda X., additional, Chen, Fa-Ming, additional, Chen, Shaochen, additional, Chesterman, Julian, additional, Chhabra, Arnav, additional, Chong, Seow Khoon, additional, Clark, Richard A.F., additional, Cleary, Muriel A., additional, Coleman, M., additional, Cotsarelis, George, additional, Crystal, Ronald G., additional, Dagnelie, Gislin, additional, Darabi, Mohammad Ali, additional, Davidson, Jeffrey M., additional, Davidson, Joseph, additional, De Coppi, Paolo, additional, Delcassian, Derfogail, additional, de Vos, Paul, additional, Dominijanni, Anthony, additional, Donahue, Ryan, additional, Drain, Allison P., additional, Duvall, Craig L., additional, Dziki, Jenna L., additional, Elgalad, Abdelmotagaly, additional, Eng, George, additional, Falanga, Vincent, additional, Farhang, Niloofar, additional, Ferreira, Lino, additional, Fink, Donald W., additional, Fleming, Heather E., additional, Fong, Peter, additional, Frey, Mark R., additional, Gay, Denise, additional, Gerecht, Sharon, additional, Gersbach, Charles A., additional, Gibbs, D.M.R., additional, Gidwani, Simran, additional, González Morales, Shaimar R., additional, Goyal, Ritu, additional, Grant, Maria B., additional, Gray, Andrea, additional, Greisler, Howard P., additional, Grikscheit, Tracy C., additional, Grosh, Karl, additional, Guilak, Farshid, additional, Guo, Jason L., additional, Han, Yingli, additional, Hare, Joshua M., additional, Hassanbhai, Ammar Mansoor, additional, Hatzistergos, Konstantinos, additional, Hay, David C., additional, He, Xiao-Tao, additional, Henderson, Timothy, additional, Hickerson, Darren, additional, Hickerson, Darren H.M., additional, Hmadcha, Abdelkrim, additional, Hochman-Mendez, Camila, additional, Huang, Chao, additional, Hubbell, Jeffrey A., additional, Huelsmann, Joern, additional, Huh, Jun Tae, additional, Hunsberger, Joshua G., additional, Iannucci, Leanne E., additional, Inoue, Haruhisa, additional, Jackson, John, additional, Jiang, Yangzi, additional, Kalinichenko, Vladimir V., additional, Kanczler, J.M., additional, Karp, Jeffrey M., additional, Kasper, F. Kurtis, additional, Khademhosseini, Ali, additional, Kim, Ji Hyun, additional, Kimbrel, Erin A., additional, Klimanskaya, Irina, additional, Kohn, Joachim, additional, Kumar, Sunil, additional, Kyriakides, Themis R., additional, Lake, Spencer P., additional, Lam, Johnny, additional, Langer, Robert, additional, Lanza, Robert, additional, Leach, Timothy S., additional, Lee, Benjamin W., additional, Lee, Iris, additional, Lee, Sang Jin, additional, Li, David, additional, Li, Linheng, additional, Liu, Qian, additional, Ljubimov, Alexander V., additional, Lo, Chi, additional, Longaker, Michael T., additional, López-Beas, Javier, additional, Loring, Jeanne F., additional, Luo, Ying, additional, MacArthur, Ben D., additional, Madigan, Nicolas N., additional, Madry, Henning, additional, Magalhaes, Renata S., additional, Manley, Nancy Ruth, additional, Mansbridge, Jonathan, additional, Mao, Jeremy J., additional, Marshall, K.M., additional, Martin, J.A., additional, Martins-Green, M., additional, Maselli, Kathryn M., additional, Maxfield, Mark W., additional, McCracken, Kyle W., additional, Melville, James, additional, Mikos, Antonios G., additional, Millán, José del R., additional, Mirotsou, Maria, additional, Montoro, Daniel T., additional, Murphy, Matthew P., additional, Murphy, Sean V., additional, Musillo, Michael, additional, Muthukumaran, Padmalosini, additional, Navara, Adam M., additional, Nelson, Christopher E., additional, Niklason, Laura E., additional, Nowell, Craig Scott, additional, O’Keefe, Regis J., additional, O’Neill, Kathy E., additional, Oreffo, Richard O.C., additional, Ortiz, Ophir, additional, Palmer, Andre Francis, additional, Perdikis, Serafeim, additional, Petreaca, M., additional, Plikus, Maksim V., additional, Porada, Christopher D., additional, Post, Mark, additional, Prokop, Aleš, additional, Puri, Raj K., additional, Qian, Pengxu, additional, Radisic, Milica, additional, Raredon, Micha Sam Brickman, additional, Richie, Ellen Rothman, additional, Rouse, Paul, additional, Sadri-Ardekani, Hooman, additional, Saltzman, W. Mark, additional, Sampaio, Luiz C., additional, Schlieve, Christopher R., additional, Sha, Su-Hua, additional, Sharpe, Paul T., additional, Shastri, V. Prasad, additional, Shi, Yanhong, additional, Shupe, Thomas, additional, Sirabella, Dario, additional, Skardal, Aleksander, additional, Slack, J.M.W., additional, Sloan, Stephen R., additional, Soker, Shay, additional, Soria, Bernat, additional, Soria-Juan, Bárbara, additional, Stockdale, Frank E., additional, Stover, Josh, additional, Stransky, Thomas, additional, Stronks, H. Christiaan, additional, Stumpf, Patrick S., additional, Sung, Kyung Eun, additional, Swarr, Daniel, additional, Szkolnicka, Dagmara, additional, Takahashi, Jun, additional, Tang, D.K.O., additional, Tang, Winson, additional, Taylor, Doris A., additional, Teng, Yao, additional, Teoh, Swee Hin, additional, Smith, Anthony J., additional, Treffeisen, Elsa, additional, Tuan, Rocky S., additional, Vacanti, Joseph P., additional, van der Weele, Cor, additional, Vincent, Matthew, additional, Vunjak-Novakovic, Gordana, additional, Wahlberg, Lars U., additional, Wan, Derrick C., additional, Wang, Anne, additional, Wang, Dan, additional, Wang, Qiwei, additional, Wang, Yanling, additional, Wang, Yu-li, additional, Wang, Zhanwen, additional, Weaver, Valerie M., additional, Wells, J.A., additional, Welter, Jean F., additional, Wen, Feng, additional, Weston, Jake, additional, Whitsett, Jeffrey A., additional, Williams, James K., additional, Windebank, Anthony J., additional, Wong, Mark Eu-Kien, additional, Worgall, Stefan, additional, Wu, Iwen, additional, Wu, Rui-Xin, additional, Xie, Virginia Y., additional, Xing, Malcolm, additional, Yamada, Kenneth M., additional, Yamanaka, Shinya, additional, Yoo, James J., additional, Young, Simon, additional, Yu, Claire, additional, Yu, Hanry, additional, Yuan, Yifan, additional, Zacharias, William, additional, Zakko, Jason, additional, Zhang, Ai, additional, Zhang, Yuanyuan, additional, Zhang, Zheng, additional, Zhao, Chunfeng, additional, Zhao, Yimu, additional, and Zoloth, Laurie, additional

Published
2020
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16. Engineered Vascularized Bone Grafts

Author

Tsigkou, Olga, Pomerantseva, Irina, Spencer, Joel A., Redondo, Patricia A., Hart, Alison R., O'Doherty, Elisabeth, Lin, Yunfeng, Friedrich, Claudia C., Daheron, Laurence, Lin, Charles P., Sundback, Cathryn A., Vacanti, Joseph P., Neville, Craig, and Badylak, Stephen F.

Published
2010
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26. Regeneration and experimental orthotopic transplantation of a bioengineered kidney

Author

Song, Jeremy J, Guyette, Jacques P, Gilpin, Sarah E, Gonzalez, Gabriel, Vacanti, Joseph P, and Ott, Harald C

Subjects
Kidneys -- Transplantation, Chronic kidney failure -- Care and treatment, Biological sciences, Health
Abstract

Building on their earlier work on heart and lung organ engineering, Jeremy Song and his colleagues have now adapted the technology of using decellularized scaffolds to develop bioengineered kidneys for transplantation. When reseeded with endothelial and epithelial cells, and after orthotopic transplantation in rats, the grafts became perfused by the recipient's circulation, produced urine and provided clearance of metabolites. Approximately 100,000 individuals in the United States currently await kidney transplantation, and 400,000 individuals live with end-stage kidney disease requiring hemodialysis. The creation of a transplantable graft to permanently replace kidney function would address donor organ shortage and the morbidity associated with immunosuppression. Such a bioengineered graft must have the kidney's architecture and function and permit perfusion, filtration, secretion, absorption and drainage of urine. We decellularized rat, porcine and human kidneys by detergent perfusion, yielding acellular scaffolds with vascular, cortical and medullary architecture, a collecting system and ureters. To regenerate functional tissue, we seeded rat kidney scaffolds with epithelial and endothelial cells and perfused these cell-seeded constructs in a whole-organ bioreactor. The resulting grafts produced rudimentary urine in vitro when perfused through their intrinsic vascular bed. When transplanted in an orthotopic position in rat, the grafts were perfused by the recipient's circulation and produced urine through the ureteral conduit in vivo., Author(s): Jeremy J Song [sup.1] [sup.2] , Jacques P Guyette [sup.1] [sup.2] , Sarah E Gilpin [sup.1] [sup.2] , Gabriel Gonzalez [sup.1] [sup.2] , Joseph P Vacanti [sup.1] [sup.2] [sup.3] [...]

Published
2013
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27. List of Contributors

Author

Afroze, Syeda H., primary, Alpini, Gianfranco, additional, Anderson, Eric C., additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Baiguera, Silvia, additional, Baiocchi, Leonardo, additional, Baptista, Pedro M., additional, Bejarano-Pineda, Lorena, additional, Benedetti, Enrico, additional, Beraldi, Rosanna, additional, Berdichevski, Alexandra, additional, Bhuyan, Mohammod, additional, Bishop, Alex G., additional, Bitar, Khalil N., additional, Blose, Kory J., additional, Brasile, Lauren, additional, Braza, Faouzi, additional, Breuer, Christopher K., additional, Brouard, Sophie, additional, Brown, Bryan N., additional, Burke, George W., additional, Butler, Peter E., additional, Butler, Colin R., additional, Calderon, Damelys, additional, Cancedda, Ranieri, additional, Cantero Peral, Susana, additional, Carbone, Marco, additional, Castanares-Zapatero, Diego, additional, Castro Santa, Edward, additional, Chatenoud, Lucienne, additional, Chawla, Reema, additional, Chen, Linda, additional, Chiono, Valeria, additional, Ciancio, Gaetano, additional, Ciardelli, Gianluca, additional, Ciccarelli, Olga, additional, Collienne, Christine, additional, Corradini, Francesca, additional, Cortiella, Joaquin, additional, Cravedi, Paolo, additional, Cypel, Marcelo, additional, Da Sacco, Stefano, additional, Date, Hiroshi, additional, Davies, Paige S., additional, De Coppi, Paolo, additional, De Luca, Michele, additional, Dean, Ethan W., additional, Degauque, Nicolas, additional, Domínguez-Bendala, Juan, additional, Dubernard, Jean Michel, additional, ElBackly, Rania M., additional, English, Karen, additional, Fändrich, Fred, additional, Farney, Alan C., additional, Faulk, Denver M., additional, García-Arrarás, José E., additional, Gianello, Pierre, additional, Giangreco, Adam, additional, Glaser, Shannon S., additional, Gobble, Ryan, additional, Goldstein, Aaron S., additional, Grant, Christa N., additional, Grikscheit, Tracy C., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, Guillot, Pascale V., additional, Hamilton, Nicholas, additional, Hantson, Philippe, additional, Hemal, Sij, additional, Hematti, Peiman, additional, Hynds, Robert E., additional, Inverardi, Luca, additional, Jacquet, Luc M., additional, Janes, Sam M., additional, Jell, Gavin, additional, Jensen, Kendal, additional, Jochmans, Ina, additional, Kanai, Nobuo, additional, Katari, Ravi, additional, Keshavjee, Shaf, additional, Kim, Jaehyup, additional, Kim, Yeonhee, additional, King, Nancy M.P., additional, Kobayashi, Eiji, additional, Koshiba, Takaaki, additional, Krawiec, Jeffrey T., additional, Kurobe, Hirotsugu, additional, Lai, Quirino, additional, Lanzoni, Giacomo, additional, Laterre, Pierre-François, additional, Lerut, Jan P., additional, Lerut, Toni, additional, Li, Ou, additional, Macchiarini, Paolo, additional, Maghsoudlou, Panagiotis, additional, Mamode, Nizam, additional, Manzia, Tommaso M., additional, Martinez-Fernandez, Almudena, additional, Martovetsky, Gleb, additional, Mastrogiacomo, Maddalena, additional, Masuda, Shigeo, additional, McQuilling, John P., additional, Mehra, Mandeep R., additional, Menasché, Philippe, additional, Meng, Fanyin, additional, Mironi-Harpaz, Iris, additional, Mirzazadeh, Majid, additional, Moiemen, Naiem S., additional, Moran, Emma, additional, Muiesan, Paolo, additional, Nardo, Tiziana, additional, Nelson, Timothy J, additional, Netti, Paolo A., additional, Neuberger, James M., additional, Nigam, Sanjay K., additional, Ohe, Hidenori, additional, Okano, Teruo, additional, Opara, Emmanuel C., additional, Orgill, Dennis P., additional, Otte, Jean-Bernard, additional, Ozer, Sinan, additional, Pareta, Rajesh A., additional, Patel, Timil, additional, Pellegrini, Graziella, additional, Peloso, Andrea, additional, Perin, Laura, additional, Petruzzo, Palmina, additional, Pinheiro, Rafael S., additional, Pirenne, Jacques, additional, Poindexter, Lauren K., additional, Pucéat, Michel, additional, Pugliese, Alberto, additional, Raghavan, Shreya, additional, Rahal, Kinan, additional, Rama, Paolo, additional, Remuzzi, Andrea, additional, Remuzzi, Giuseppe, additional, Reyna-Soriano, Daniel, additional, Rico Juri, Juan M., additional, Ricordi, Camillo, additional, Roberts, Keith J., additional, Rocco, Kevin A., additional, Rodriguez-Devora, Jorge I., additional, Rogers, Jeffrey, additional, Rudnick, David A., additional, Ruggenenti, Piero, additional, Sageshima, Junichiro, additional, Salvatori, Marcus, additional, Samavedi, Satyavrata, additional, Sannino, Alessandro, additional, Scalera, Irene, additional, Sedaghati, Tina, additional, Sedrakyan, Sargis, additional, Seifalian, Alexander M., additional, Seifalian, Amelia, additional, Seliktar, Dror, additional, Selvaggi, Gennaro, additional, Shapira-Schweitzer, Keren, additional, Shinoka, Toshiharu, additional, Shupe, Thomas, additional, Smith, Nicholas R., additional, Soulillou, Jean-Paul, additional, Spinelli, Valentina, additional, Sutherland, David E.R., additional, Tara, Shuhei, additional, Teratani, Takumi, additional, Terzic, Andre, additional, Thomas, Sunu S., additional, Tisone, Giuseppe, additional, Totonelli, Giorgia, additional, Tzakis, Andreas, additional, Tzvetanov, Ivo G., additional, Udelsman, Brooks V., additional, Uygun, Basak E., additional, Vacanti, Joseph P., additional, Van Caenegem, Olivier, additional, Van Dyke, Mark, additional, Van Raemdonck, Dirk E., additional, Vorp, David A., additional, Vyas, Dipen, additional, Wang, Kun, additional, Weinbaum, Justin S., additional, Wertheim, Jason A., additional, Williams, David F., additional, Wittebole, Xavier, additional, Wong, Melissa H., additional, Wood, Kathryn J., additional, Xu, Tao, additional, Yamato, Masayuki, additional, You, Sylvaine, additional, Yuan, Yuyu, additional, Zambon, Joao Paulo, additional, Zattoni, Michela, additional, and Zhu, Lei, additional

Published
2014
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29. List of Contributors

Author

Bowles, Robby D., primary, (Tony) Smith, Anthony J., additional, Ahlstrom, Jon D., additional, Albon, Julie, additional, Alexander, Peter G., additional, Altschuler, Richard A., additional, Alvarez, Pedro, additional, Amendola, A., additional, Anatol, Rachael, additional, Annabi, Nasim, additional, Anversa, Piero, additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Athanasiou, Kyriacos A., additional, Auger, François A., additional, Auguste, Debra T., additional, Awad, Hani A., additional, Badylak, Stephen F., additional, Bailey, Alexander M., additional, Barry, Michael P., additional, Becker, Daniel, additional, Belegu, Visar, additional, Bernhard, Jonathan, additional, Bertram, Timothy, additional, Besnard, Valérie, additional, Bhat, Z.F., additional, Bhat, Hina, additional, Bhatia, Sangeeta N., additional, Bhumiratana, Sarindr, additional, Bianco, Paolo, additional, Blackburn, Catherine Clare, additional, Bollenbach, Thomas, additional, Bonassar, Lawrence A., additional, Boulton, Mike, additional, Bradshaw, Amy D., additional, Breuer, Christopher K., additional, Brewster, Luke, additional, Brey, Eric M., additional, Brittan, Mairi, additional, Brown, Bryan N., additional, Brown, T., additional, Buckwalter, J.A., additional, Buffington, Deborah, additional, Burg, Karen J.L., additional, Burg, Timothy C., additional, Chabaud, Stéphane, additional, Swi Chang, Thomas Ming, additional, Chang, Yunchao, additional, Chapman, Robert G., additional, Chen, Fa-Ming, additional, Chen, Una, additional, Cimetta, Elisa, additional, Clark, Richard A.F., additional, Clark, Karen L., additional, Cleary, Muriel A., additional, Cloutier, Réjean, additional, Colton, Clark K., additional, Cotsarelis, George, additional, Crystal, Ronald G., additional, Dagnelie, Gislin, additional, da Silva Ferreira, Lino, additional, Davidson, Jeffrey M., additional, Deuel, Thomas F., additional, Direkze, Natalie, additional, Dressler, Gregory R., additional, Durfor, Charles N., additional, Duvall, Craig L., additional, Eng, George, additional, Engelmayr, George, additional, Eschenhagen, Thomas, additional, Eu-Kien Wong, Mark, additional, Falanga, Vincent, additional, Faria, Katie, additional, Faustman, Denise L., additional, Fauza, Dario O., additional, Feng, Qiang, additional, Ferreira, Lino, additional, Fink, Donald W., additional, Fissell, William, additional, Freed, Lisa E., additional, Furth, Mark E., additional, Gay, Denise, additional, Gerecht-Nir, Sharon, additional, Germain, Lucie, additional, Gersbach, Charles A., additional, Goulet, Francine, additional, Goyal, Ritu, additional, Grant, Maria B., additional, Greisler, Howard P., additional, Guilak, Farshid, additional, Harley, Brendan A.C., additional, Hart, David A., additional, Hmadcha, Abdelkrim, additional, Hodges, Steve J., additional, Hofer, Heidi R., additional, Hollinger, Jeffrey O., additional, Holobaugh, Patricia, additional, Hubbell, Jeffrey A., additional, Humes, H. David, additional, Ingber, Donald E., additional, Inskeep, Beau, additional, Jiang, Xingyu, additional, Kajstura, Jan, additional, Kane, Ravi S., additional, Karp, Jeffrey M., additional, Kasper, F. Kurtis, additional, Khademhosseini, Ali, additional, Kili, Sven, additional, Kimbrel, Erin A., additional, Klimanskaya, Irina, additional, Kohn, Joachim, additional, Kunisaki, Shaun M., additional, Kyriakides, Themis R., additional, Lagasse, Eric, additional, Lamontagne, Jean, additional, Langer, Robert, additional, Lanza, Robert, additional, Lecht, Shimon, additional, Lee, Benjamin W., additional, Lee, Chang H., additional, Lee, Mark H., additional, Lelkes, Peter I., additional, Leri, Annarosa, additional, Levine, David W., additional, Li, Feng, additional, Longaker, Michael T., additional, López, Javier, additional, Lu, Shi-Jiang, additional, Luo, Ying, additional, MacArthur, Ben D., additional, Manley, Nancy Ruth, additional, Manohar, Rohan, additional, Mansbridge, Jonathan, additional, Mantalaris, Athanasios, additional, Mao, Jeremy J., additional, Marsh, J.L., additional, Martin, David C., additional, Martin, J.A., additional, Martins-Green, M., additional, Masuda, Koichi, additional, Maxfield, Mark W., additional, McCabe, Kathryn L., additional, McDonald, John W., additional, McFarland, Richard, additional, Mikos, Antonios G., additional, Millán, José del R., additional, Miller, Josef M., additional, Mills, Shari, additional, Moffat, Kristen L., additional, Mondrinos, Mark J., additional, Montoro, Daniel T., additional, Moore, Malcolm A.S., additional, Neal, Rebekah A., additional, Nerem, Robert M., additional, Ng, Shengyong, additional, Nowell, Craig Scott, additional, Obokata, Haruko, additional, Olsen, Bjorn Reino, additional, Oreffo, Richard O.C., additional, O’Keefe, Regis J., additional, O’Neill, Kathy, additional, Ortiz, Ophir, additional, Pan, Carolyn K., additional, Pathak, Vikas, additional, Petreaca, M., additional, Pezzolla, Daniela, additional, Plikus, Maksim V., additional, Polak, Julia M., additional, Post, Mark, additional, Preston, Sean, additional, Prokop, Aleš, additional, Radisic, Milica, additional, Ranghini, Egon, additional, Raphael, Yehoash, additional, Reddi, A.H., additional, Reichenspurner, Herrmann, additional, Richie, Ellen, additional, Robey, Pamela Gehron, additional, Robinson, Becky, additional, Rojas, Anabel, additional, Roy, Shuvo, additional, Russell, Alan J., additional, Saigal, Rajiv, additional, Saltzman, W. Mark, additional, Samadikuchaksaraei, Ali, additional, Sambanis, Athanassios, additional, Schacht, Jochen, additional, Schutte, Stacey C., additional, Schutte, Lyndsey, additional, Schwartz, Steven D., additional, Schwartz, Robert E., additional, Setton, Lori A., additional, Sha, Su-Hua, additional, Shan, Jing, additional, Sharpe, Paul T., additional, Shi, Songtao, additional, Shrivats, Arun R., additional, Simon, Franck, additional, Sirabella, Dario, additional, Slack, J.M.W., additional, Soria, Bernat, additional, Spicer, Patrick, additional, Stevens, Kelly R., additional, Stockdale, Frank E., additional, Christiaan Stronks, H., additional, Studer, Lorenz, additional, Takayama, Shuichi, additional, Thomson, James A., additional, Trachtenberg, Jordan E., additional, Treffeisen, Elsa, additional, Tuan, Rocky S., additional, Vacanti, Charles A., additional, Vacanti, Joseph P., additional, van der Weele, Cor, additional, Vincent, Matthew, additional, Vunjak-Novakovic, Gordana, additional, Wahlberg, Lars U., additional, Wan, Derrick C., additional, Wang, Anne, additional, Westover, Angela J., additional, Whitesides, George M., additional, Whitsett, Jeffrey A., additional, Winitsky, Steve, additional, Witten, Celia, additional, Worgall, Stefan, additional, Wright, Nicholas A., additional, Yannas, Ioannis V., additional, Young, Simon, additional, Yu, Junying, additional, Zhang, Zheng, additional, Zheng, Wenfu, additional, Zimmermann, Wolfram Hubertus, additional, and Zoloth, Laurie, additional

Published
2014
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30. Introduction

Author

Vacanti, Joseph P., primary, Otte, Jean-Bernard, additional, and Wertheim, Jason A., additional

Published
2014
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32. Preface

Author

Lanza, Robert, primary, Langer, Robert, additional, and Vacanti, Joseph P., additional

Published
2014
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39. Elastic averaging for assembly of three-dimensional constructs from elastomeric micromolded layers

Author

Marentis, Theodore C., Vacanti, Joseph P., Hsiao, James C., and Borenstein, Jeffrey T.

Subjects
Microfluidics -- Research, Elastomers -- Properties, Embedded systems -- Design and construction, Tissue engineering -- Research, Machining -- Methods, Embedded system, System on a chip, Engineering and manufacturing industries, Science and technology
Abstract

Precision engineering has been used in the macro-world and in the microscale only with rigid materials. Soft flexible materials commonly used for microfluidics and other bio-MEMS applications have not been aligned with elastic averaging. We report the use of complementary raised and recessed circular features to align polymer layers and demonstrate alignment accuracy and repeatability. The alignment is accomplished in a Petri dish with a thin layer of liquid between the two surfaces of micro-molded elastomeric polymer sheets. The layers are aligned with simple hand-eye manipulation. We test circular geometries of varying diameters, obtaining accuracy and repeatability values in the range of 1-3 [micro]m across thin polymer sheets molded from silicon masters. This is a significant improvement over existing manual, moving stage, and self-alignment techniques and a novel proof of concept that paves the way for complex 3-D polymer constructs. [2008-0093] Index Terms--Alignment, biomedical engineering, elastic averaging, lab-on-a-chip, microassembly, microfluidics, micromachining, poly-(dimethylsiloxane) (PDMS), precision engineering, silicone rubbers, surface fitting, tissue engineering.

Published
2009

43. Contributors

Author

Adams, Mark C., primary, Adibe, Obinna O., additional, Adler, Jeremy, additional, Adzick, N. Scott, additional, Albanese, Craig T., additional, Andrews, Walter S., additional, Applebaum, Harry, additional, Arca, Marjorie J., additional, Aronson, Daniel C., additional, Azizkhan, Richard G., additional, Baird, Robert, additional, Barnett, Sean, additional, Barnhart, Douglas C., additional, Barsness, Katherine A., additional, Bartlett, Robert H., additional, Baskin, Laurence S., additional, Beasley, Spencer W., additional, Bentz, Michael L., additional, Billmire, Deborah F., additional, Boulanger, Scott C., additional, Brandt, Mary L., additional, Brock, John W., additional, Brown, Rebeccah L., additional, Btaiche, Imad F., additional, Busuttil, Ronald W., additional, Caldamone, Anthony A., additional, Caniano, Donna A., additional, Caty, Michael G., additional, Chardot, Christophe, additional, Chung, Dai H., additional, Cilley, Robert E., additional, Colon, Nadja C., additional, Columbani, Paul M., additional, Coran, Arnold G., additional, Cotton, Robin T., additional, Cowles, Robert A., additional, Cox,, Charles S., additional, Dassinger, Melvin S., additional, Davidoff, Andrew M., additional, Davidson, Richard S., additional, Coppi, Paolo De, additional, Dicken, Bryan J., additional, Didelot, William, additional, DiFiore, John W., additional, Dillon, Patrick A., additional, Dillon, Peter W., additional, Donahoe, Patricia K., additional, Duchossois, Gina P., additional, Dunn, James C.Y., additional, Dutta, Sanjeev, additional, Eaton, Simon, additional, Ehrlich, Peter F., additional, Eichelberger, Martin R., additional, Elden, Lisa M., additional, Eliason, Jonathan L., additional, Emil, Sherif, additional, Escobar, Mauricio A., additional, Falcone,, Richard A., additional, Fallat, Mary E., additional, Farmer, Diana L., additional, Farmer, Douglas G., additional, Faro, Albert, additional, Fisher, Michael J., additional, Fishman, Steven J., additional, Fitzgerald, Tamara N., additional, Flake, Alan W., additional, Foglia, Robert P., additional, Ford, Henri R., additional, Franklin, Andrew, additional, Frischer, Jason S., additional, Fuller, Stephanie M.P., additional, Gandhi, Sanjiv K., additional, Garcia, Victor F., additional, Gatti, John M., additional, Gauderer, Michael W.L., additional, Geiger, James D., additional, Georgeson, Keith E., additional, Gingalewski, Cynthia A., additional, Glassberg, Kenneth I., additional, Glick, Philip L., additional, Gonzales, Kelly D., additional, Grikscheit, Tracy C., additional, Grosfeld, Jay L., additional, Groth, Travis W., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, Gutierrez, Ivan M., additional, Guzzetta,, Philip C., additional, J. Hall, Jason, additional, Hamilton, Thomas E., additional, Harmon, Carroll M., additional, Harrison, Michael R., additional, Hayes-Jordan, Andrea, additional, Hays, Stephen R., additional, Healey, John H., additional, Hendren, W. Hardy, additional, Hering, Bernhard J., additional, Herndon, David N., additional, Hirose, Shinjiro, additional, Hirsch, Jennifer C., additional, Hirschl, Ronald B., additional, Hoganson, David M., additional, Holcomb, George W., additional, Höllwarth, Michael E., additional, Horn, B. David, additional, Huddleston, Charles B., additional, Hutchinson, Raymond J., additional, Hutson, John M., additional, Hyun, Grace, additional, Inge, Thomas H., additional, Jaksic, Tom, additional, Jea, Andrew, additional, Kaefer, Martin, additional, Kang, Kuang Horng, additional, Karsanac, Christopher J., additional, Kayes, Kosmas, additional, Kelly, Robert E., additional, Kiely, Edward M., additional, Klein, Michael D., additional, Krasin, Matthew J., additional, Krummel, Thomas M., additional, Kulungowski, Ann M., additional, Laberge, Jean-Martin, additional, Landsman, Ira S., additional, Langer, Jacob C., additional, La Quaglia, Michael P., additional, Laufer, Marc R., additional, Lee, Hanmin, additional, Lelli, Joseph L., additional, Levitt, Marc A., additional, Liau, James Y., additional, Lillehei, Craig, additional, Lindahl, Harry, additional, Liu, Gigi Y., additional, Lorenz, H. Peter, additional, Luerssen, Thomas G., additional, Lukish, Jeffrey R., additional, Lund, Dennis P., additional, Magee, John C., additional, McGahren, Eugene D., additional, McLaughlin, Eamon J., additional, McQuiston, Leslie T., additional, Meyers, Rebecka L., additional, Millar, Alastair J.W., additional, Minevich, Eugene, additional, Miranda, Edward P., additional, Mitchell, Michael E., additional, Mollen, Kevin P., additional, Moss, R. Lawrence, additional, Mouriquand, Pierre, additional, Murase, Noriko, additional, Murphy, J. Patrick, additional, Murphy, Joseph T., additional, Nance, Michael L., additional, Nathan, Saminathan S., additional, Newman, Kurt D., additional, Numanoglu, Alp, additional, Nwomeh, Benedict C., additional, Ohye, Richard G., additional, Oldham, Keith T., additional, O'Neill, James A., additional, Pakarinen, Mikko P., additional, Panait, Nicoleta, additional, Pearl, Richard H., additional, Peña, Alberto, additional, Pieretti, Rafael V., additional, Pierro, Agostino, additional, Piper, Hannah G., additional, Potsic, William P., additional, Pryor, Howard I., additional, Puligandla, Pramod S., additional, Puri, Prem, additional, Qureshi, Faisal G., additional, Rescorla, Frederick J., additional, Révillon, Yann, additional, Reyes, Jorge, additional, Reynolds, Marleta, additional, Rhee, Audrey C., additional, Rich, Barrie S., additional, Ricketts, Richard R., additional, Rink, Richard C., additional, Rintala, Risto J., additional, Rocchini, Albert P., additional, Rodeberg, David A., additional, Sadove, A. Michael, additional, Saggi, Bob H., additional, Scherer, L.R., additional, Schmid, Daniel B., additional, Scholz, Stefan, additional, Schwartz, Marshall Z., additional, Shamberger, Robert C., additional, Shapiro, Nina L., additional, Sheldon, Curtis A., additional, Shochat, Stephen J., additional, Sidell, Douglas, additional, Skinner, Michael A., additional, Smith, Jodi L., additional, Smith, Samuel D., additional, Snyder, Charles L., additional, Speer, Allison L., additional, Spitz, Lewis, additional, Spray, Thomas L., additional, Stanley, James C., additional, Starzl, Thomas E., additional, Stehr, Wolfgang, additional, Stolar, Charles J.H., additional, Storm, Phillip B., additional, Stylianos, Steven, additional, Subramaniam, Ramnath, additional, Superina, Riccardo, additional, Sutherland, David E.R., additional, Sutton, Leslie N., additional, Sydorak, Roman, additional, Sylvester, Karl G., additional, Teitelbaum, Daniel H., additional, Tepas, Joseph J., additional, Thomas, John C., additional, Thompson, Dana Mara, additional, Tovar, Juan A., additional, Upperman, Jeffrey S., additional, Vacanti, Joseph P., additional, van Aalst, John A., additional, Vane, Dennis W., additional, Allmen, Daniel Von, additional, Walkovich, Kelly, additional, Walsh, Danielle S., additional, Warner, Brad W., additional, Weber, Thomas R., additional, Weldon, Christopher B., additional, Wesson, David E., additional, Wetmore, Ralph F., additional, Willging, J. Paul, additional, Wilson, Jay M., additional, Woo, Lynn L., additional, Woo, Russell K., additional, Yerkes, Elizabeth B., additional, Ziegler, Moritz M., additional, and Zimmermann, Arthur, additional

Published
2012
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45. Regenerative medicine: postnatal approaches

Author

Tam, Paul Kwong Hang, Wong, Kenneth Kak Yuen, Atala, Anthony, Giobbe, Giovanni Giuseppe, Booth, Claire, Gruber, Peter J, Mononen, Mimmi, Rafii, Shahin, Rando, Thomas A, Vacanti, Joseph, Comer, Carly D, Elvassore, Nicola, Grikscheit, Tracy, and de Coppi, Paolo

Abstract

Paper 2 of the paediatric regenerative medicine Series focuses on recent advances in postnatal approaches. New gene, cell, and niche-based technologies and their combinations allow structural and functional reconstitution and simulation of complex postnatal cell, tissue, and organ hierarchies. Organoid and tissue engineering advances provide human disease models and novel treatments for both rare paediatric diseases and common diseases affecting all ages, such as COVID-19. Preclinical studies for gastrointestinal disorders are directed towards oesophageal replacement, short bowel syndrome, enteric neuropathy, biliary atresia, and chronic end-stage liver failure. For respiratory diseases, beside the first human tracheal replacement, more complex tissue engineering represents a promising solution to generate transplantable lungs. Genitourinary tissue replacement and expansion usually involve application of biocompatible scaffolds seeded with patient-derived cells. Gene and cell therapy approaches seem appropriate for rare paediatric diseases of the musculoskeletal system such as spinal muscular dystrophy, whereas congenital diseases of complex organs, such as the heart, continue to challenge new frontiers of regenerative medicine.

Published
2022
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46. Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine

Author

Ramsanahie, Anthony, Duxbury, Mark S., Grikscheit, Tracy C., Perez, Alexander, Rhoads, David B., Gardner-Thorpe, James, Ogilvie, Jennifer, Ashley, Stanley W., Vacanti, Joseph P., and Whang, Edward E.

Subjects
Tissue engineering -- Research, Biological sciences
Abstract

Using tissue-engineering techniques, we have developed a neointestine that regenerates the structural and dynamic features of native small intestine. In this study, we tested neointestinal responsiveness to glucagon-like peptide 2 (GLP-2). Neointestinal cysts were engineered by seeding biodegradable polymers with neonatal rat intestinal organoid units. The cysts were matured and anastomosed to the native jejunum of syngeneic adult recipients. Animals were treated with GLP-2 [[Gly.sup.2]] (twice daily, 1 [micro]g/g body wt) or vehicle alone (control) for 10 days. Rats were then killed, and tissues were harvested for analysis. [Na.sup.+]-glucose cotransporter (SGLT1) mRNA expression was assessed with Northern blotting and in situ hybridization. SGLT1 protein was localized by using immunofluorescence. GLP-2 administration resulted in 1.8- and 1.7-fold increases (P < 0.05) in neointestinal villus height and crypt depth, respectively. GLP-2 administration also resulted in a 2.4-fold increase (P < 0.01) in neomucosal SGLT1 mRNA expression. SGLT1 mRNA expression was localized to enterocytes throughout the villi, and SGLT1 protein was localized to the brush border of enterocytes along the entire length of villi from the neointestine of GLP-2-treated animals. The response of tissue-engineered neointestine to exogenous GLP-2 includes mucosal growth and enhanced SGLT1 expression. Therefore, tissue-engineering principles may help in dissecting the regulatory mechanisms mediating complex processes in the intestinal epithelium. tissue engineering; neomucosa; glucagon-like peptide-2; sodium-glucose cotransporter 1

Published
2003

50. Contributors

Author

Aboody, Karen S., primary, Ali, Omar A., additional, Amable, Rose, additional, Barakat, D.J., additional, Bjerkvig, Rolf, additional, Le Blanc, Katarina, additional, Bonner-Weir, Susan, additional, Borlongan, Cesario V., additional, Burns, Justin M., additional, Cai, Jingli, additional, Cameron, Don F., additional, Casingal, Vince P., additional, Castellanos, Daniel A., additional, Colton, Clark K., additional, Davis, Bryce H., additional, Déglon, Nicole, additional, Dunnett, Stephen B., additional, El-Badri, Nagwa S., additional, Emerich, Dwaine F., additional, Enger, Per Oyvind, additional, English, Denis K., additional, Escartin, Carole, additional, Eto, Yoshikatsu, additional, Freed, William J., additional, Gajavelli, Shyam, additional, Garbuzova-Davis, Svitlana, additional, Gómez-Vargas, Andrew, additional, Gores, Paul F., additional, Granholm, Ann-Charlotte, additional, Hakki, Amal, additional, Halberstadt, Craig, additional, Hammerman, Marc R., additional, Hantraye, Philippe, additional, Hara, Koichi, additional, Hedger, Mark P., additional, Henning, Robert, additional, Hess, David C., additional, Hortelano, Gonzalo, additional, Huard, Johnny, additional, Humes, David H., additional, Kin, Tatsuya, additional, Klasko, Stephen K., additional, Kojima, Koji, additional, Krebs, Nicholas J., additional, Lakey, Jonathan R.T., additional, Lavasani, Mitra, additional, Lee, Chun-Ting, additional, Matsukawa, Noriyuki, additional, Mirbolooki, Mohammadreza, additional, Mooney, David J., additional, Neville, Craig, additional, Ohashi, Toya, additional, Omer, Abdulkadir, additional, O'Neil, Jack J., additional, Ott, Harald C., additional, Papas, Klearchos K., additional, Pearse, D.D., additional, Pisania, Anna, additional, Platt, Jeffrey L., additional, Pollett, Jonathan, additional, Pollinger, Harrison S., additional, Powers, Daryl E., additional, Rao, Mahendra, additional, Rappel, Michael J., additional, Rosser, Anne E., additional, Sagen, Jacqueline, additional, Sanberg, Paul R., additional, Sanchez, Joseph F., additional, Scharp, David W., additional, Schoen, Cynthia, additional, Schwartz, Catherine, additional, Senior, Peter A., additional, Shapiro, James A.M., additional, Sonntag, Kai-Christian, additional, Stahl, Christine E., additional, Taylor, Doris A., additional, Terzis, A.J.A., additional, Thanos, Chris, additional, Tiranathanagul, Khajohn, additional, Tyndall, Alan, additional, Vacanti, Charles A., additional, Vacanti, Joseph P., additional, Vasconcellos, Alfred V., additional, Vazin, Tandis, additional, Wang, Jian, additional, Wang, Yun, additional, Weir, Gordon, additional, Willing, Alison E., additional, White, David, additional, Xu, Lin, additional, Yasuhara, Takao, additional, Yu, Guolong, additional, and Zeng, Xianmin, additional

Published
2007
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