519 results on '"Vacca, Michele"'
Search Results
2. Exploring the impact of the PNPLA3 I148M variant on primary human hepatic stellate cells using 3D extracellular matrix models
- Author
-
Caon, Elisabetta, Martins, Maria, Hodgetts, Harry, Blanken, Lieke, Vilia, Maria Giovanna, Levi, Ana, Thanapirom, Kessarin, Al-Akkad, Walid, Abu-Hanna, Jeries, Baselli, Guido, Hall, Andrew R., Luong, Tu Vinh, Taanman, Jan-Willem, Vacca, Michele, Valenti, Luca, Romeo, Stefano, Mazza, Giuseppe, Pinzani, Massimo, and Rombouts, Krista
- Published
- 2024
- Full Text
- View/download PDF
3. β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development.
- Author
-
Rao, Shuyun, Yang, Xiaochun, Ohshiro, Kazufumi, Zaidi, Sobia, Wang, Zhanhuai, Shetty, Kirti, Xiang, Xiyan, Hassan, Md, Mohammad, Taj, Latham, Patricia, Nguyen, Bao-Ngoc, Wong, Linda, Yu, Herbert, Al-Abed, Yousef, Mishra, Bibhuti, Vacca, Michele, Guenigault, Gareth, Allison, Michael, Vidal-Puig, Antonio, Benhammou, Jihane, Alvarez, Marcus, Pajukanta, Päivi, Pisegna, Joseph, and Mishra, Lopa
- Subjects
Animals ,Diet ,High-Fat ,Liver ,Mice ,Mice ,Inbred C57BL ,Neoplasms ,Non-alcoholic Fatty Liver Disease ,Spectrin - Abstract
The prevalence of nonalcoholic steatohepatitis (NASH) and liver cancer is increasing. De novo lipogenesis and fibrosis contribute to disease progression and cancerous transformation. Here, we found that β2-spectrin (SPTBN1) promotes sterol regulatory element (SRE)–binding protein (SREBP)–stimulated lipogenesis and development of liver cancer in mice fed a high-fat diet (HFD) or a western diet (WD). Either hepatocyte-specific knockout of SPTBN1 or siRNA-mediated therapy protected mice from HFD/WD-induced obesity and fibrosis, lipid accumulation, and tissue damage in the liver. Biochemical analysis suggested that HFD/WD induces SPTBN1 and SREBP1 cleavage by CASPASE-3 and that the cleaved products interact to promote expression of genes with sterol response elements. Analysis of human NASH tissue revealed increased SPTBN1 and CASPASE-3 expression. Thus, our data indicate that SPTBN1 represents a potential target for therapeutic intervention in NASH and liver cancer.
- Published
- 2021
4. Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis
- Author
-
Anstee, Quentin M, Daly, Ann K, Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J, Day, Christopher P, Wonders, Kristy, Missier, Paolo, McTeer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M, Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G, Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M, Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K, Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioannis, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J, Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, McGlinchey, Aiden, Mato, Jose M, Millet, Óscar, Dufour, Jean-François, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Rasmussen, Daniel Guldager Kring, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattias, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M P, Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andreas, Trautwein, Christian, Reißing, Johanna, Aithal, Guruprasad P, Francis, Susan, Palaniyappan, Naaventhan, Bradley, Christopher, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W, Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, McLeod, Euan James, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Coxson, Harvey, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Kjær, Mette Skalshøi, Harder, Lea Mørch, Davidsen, Peter, Ellegaard, Jens, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Douglas, Shankar, Sudha, Torstenson, Richard, Lindén, Daniel, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D, Billin, Andrew, Doward, Lynda, Twiss, James, Thakker, Paresh, Derdak, Zoltan, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, Mózes, Ferenc E, Lee, Jenny A, Alzoubi, Osama, Staufer, Katharina, Trauner, Michael, Paternostro, Rafael, Stauber, Rudolf E, van Dijk, Anne-Marieke, Mak, Anne Linde, de Saint Loup, Marc, Shima, Toshihide, Gaia, Silvia, Shalimar, Lupșor-Platon, Monica, Wong, Vincent Wai-Sun, Li, Guanlin, Wong, Grace Lai-Hung, Karlas, Thomas, Wiegand, Johannes, Sebastiani, Giada, Tsochatzis, Emmanuel, Liguori, Antonio, Yoneda, Masato, Nakajima, Atsushi, Hagström, Hannes, Akbari, Camilla, Hirooka, Masashi, Chan, Wah-Kheong, Mahadeva, Sanjiv, Rajaram, Ruveena, Zheng, Ming-Hua, George, Jacob, Eslam, Mohammed, Viganò, Mauro, Ridolfo, Sofia, Aithal, Guruprasad Padur, Lee, Dae Ho, Nasr, Patrik, Cassinotto, Christophe, de Lédinghen, Victor, Mendoza, Yuly P, Noureddin, Mazen, Truong, Emily, and Harrison, Stephen A
- Published
- 2023
- Full Text
- View/download PDF
5. Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
- Author
-
Seyres, Denis, Cabassi, Alessandra, Lambourne, John J., Burden, Frances, Farrow, Samantha, McKinney, Harriet, Batista, Joana, Kempster, Carly, Pietzner, Maik, Slingsby, Oliver, Cao, Thong Huy, Quinn, Paulene A., Stefanucci, Luca, Sims, Matthew C., Rehnstrom, Karola, Adams, Claire L., Frary, Amy, Ergüener, Bekir, Kreuzhuber, Roman, Mocciaro, Gabriele, D’Amore, Simona, Koulman, Albert, Grassi, Luigi, Griffin, Julian L., Ng, Leong Loke, Park, Adrian, Savage, David B., Langenberg, Claudia, Bock, Christoph, Downes, Kate, Wareham, Nicholas J., Allison, Michael, Vacca, Michele, Kirk, Paul D. W., and Frontini, Mattia
- Published
- 2022
- Full Text
- View/download PDF
6. Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle
- Author
-
McNally, Ben D., Ashley, Dean F., Hänschke, Lea, Daou, Hélène N., Watt, Nicole T., Murfitt, Steven A., MacCannell, Amanda D. V., Whitehead, Anna, Bowen, T. Scott, Sanders, Francis W. B., Vacca, Michele, Witte, Klaus K., Davies, Graeme R., Bauer, Reinhard, Griffin, Julian L., and Roberts, Lee D.
- Published
- 2022
- Full Text
- View/download PDF
7. RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
- Author
-
Belenguer, Germán, Mastrogiovanni, Gianmarco, Pacini, Clare, Hall, Zoe, Dowbaj, Anna M., Arnes-Benito, Robert, Sljukic, Aleksandra, Prior, Nicole, Kakava, Sofia, Bradshaw, Charles R., Davies, Susan, Vacca, Michele, Saeb-Parsy, Kourosh, Koo, Bon-Kyoung, and Huch, Meritxell
- Published
- 2022
- Full Text
- View/download PDF
8. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance
- Author
-
Clark, James, Cordell, Heather J., Darlay, Rebecca, Day, Christopher P., Hardy, Tim, Liu, Yang-Lin, Oakley, Fiona, Palmer, Jeremy, Queen, Rachel, Wonders, Kristy, Bossuyt, Patrick M., Holleboom, Adriaan G., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Clement, Karine, Pais, Raluca, Schuppan, Detlef, Allison, Michael, Cuenca, Sergio Rodriguez, Pellegrinelli, Vanessa, Vacca, Michele, Vidal-Puig, Antonio, Hyötyläinen, Tuulia, McGlinchey, Aidan, Orešič, Matej, Sen, Partho, Mato, Jose, Millet, Óscar, Dufour, Jean-Francois, Harrison, Stephen, Neubauer, Stefan, Pavlides, Michael, Mozes, Ferenc, Akhtar, Salma, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Erpicum, Charlotte, Romero-Gomez, Manuel, Gallego-Durán, Rocío, Fernández, Isabel, Karsdal, Morten, Leeming, Diana, Fisker, Mette Juul, Erhardtsen, Elisabeth, Rasmussen, Daniel, Qvist, Per, Sinisi, Antonia, Sandt, Estelle, Tonini, Maria Manuela, Parola, Maurizio, Rosso, Chiara, Marra, Fabio, Gastaldelli, Amalia, Francque, Sven, Kechagias, Stergios, Yki-Järvinen, Hannele, Porthan, Kimmo, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Valenti, Luca, Petta, Salvatore, Miele, Luca, Geier, Andreas, Trautwein, Christian, Hockings, Paul, Newsome, Phil, Wenn, David, Pereira Rodrigues, Cecília Maria, Hanf, Rémy, Chaumat, Pierre, Rosenquist, Christian, Trylesinski, Aldo, Ortiz, Pablo, Duffin, Kevin, Yunis, Carla, Miller, Melissa, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Alexander, Leigh, Ostroff, Rachel, Kjær, Mette Skalshøi, Mikkelsen, Lars Friis, Brass, Clifford, Jennings, Lori, Balp, Maria-Magdalena, Martic, Miljen, Hanauer, Guido, Shankar, Sudha, Torstenson, Richard, Fournier, Céline, Ehman, Richard, Kalutkiewicz, Michael, Pepin, Kay, Myers, Joel, Shevell, Diane, Ho, Gideon, Landgren, Henrik, Myers, Rob, Doward, Lynda, Whalley, Diane, Twiss, James, Johnson, Katherine, Leary, Peter J., Govaere, Olivier, Barter, Matthew J., Charlton, Sarah H., Cockell, Simon J., Tiniakos, Dina, Zatorska, Michalina, Bedossa, Pierre, Brosnan, M. Julia, Cobbold, Jeremy F., Ekstedt, Mattias, Aithal, Guruprasad P., Clément, Karine, Schattenberg, Jörn M., Boursier, Jerome, Ratziu, Vlad, Bugianesi, Elisabetta, Anstee, Quentin M., and Daly, Ann K.
- Published
- 2022
- Full Text
- View/download PDF
9. Innovation in hematopoietic stem cell cryopreservation and cold chain management
- Author
-
Prisciandaro, Michele, primary, Santodirocco, Michele, additional, Fania, Giuseppe, additional, and Vacca, Michele, additional
- Published
- 2024
- Full Text
- View/download PDF
10. Stem Cells Collection and Mobilization in Adult Autologous/Allogeneic Transplantation: Critical Points and Future Challenges
- Author
-
Prisciandaro, Michele, primary, Santinelli, Enrico, additional, Tomarchio, Valeria, additional, Tafuri, Maria Antonietta, additional, Bonchi, Cecilia, additional, Palazzo, Gloria, additional, Nobile, Carolina, additional, Marinucci, Alessandra, additional, Mele, Marcella, additional, Annibali, Ombretta, additional, Rigacci, Luigi, additional, and Vacca, Michele, additional
- Published
- 2024
- Full Text
- View/download PDF
11. Intracoronary monocyte expression pattern and HDL subfractions after non-ST elevation myocardial infarction
- Author
-
Cariello, Marica, Salvia, Roberto, Härdfeldt, Jennifer, Piglionica, Marilidia, Rutigliano, David, Caldarola, Pasquale, Ossoli, Alice, Vacca, Michele, Graziano, Giusi, Battaglia, Stefano, Zerlotin, Roberta, Arconzo, Maria, Crudele, Lucilla, Sabbà, Carlo, Calabresi, Laura, and Moschetta, Antonio
- Published
- 2021
- Full Text
- View/download PDF
12. NASH limits anti-tumour surveillance in immunotherapy-treated HCC
- Author
-
Pfister, Dominik, Núñez, Nicolás Gonzalo, Pinyol, Roser, Govaere, Olivier, Pinter, Matthias, Szydlowska, Marta, Gupta, Revant, Qiu, Mengjie, Deczkowska, Aleksandra, Weiner, Assaf, Müller, Florian, Sinha, Ankit, Friebel, Ekaterina, Engleitner, Thomas, Lenggenhager, Daniela, Moncsek, Anja, Heide, Danijela, Stirm, Kristin, Kosla, Jan, Kotsiliti, Eleni, Leone, Valentina, Dudek, Michael, Yousuf, Suhail, Inverso, Donato, Singh, Indrabahadur, Teijeiro, Ana, Castet, Florian, Montironi, Carla, Haber, Philipp K., Tiniakos, Dina, Bedossa, Pierre, Cockell, Simon, Younes, Ramy, Vacca, Michele, Marra, Fabio, Schattenberg, Jörn M., Allison, Michael, Bugianesi, Elisabetta, Ratziu, Vlad, Pressiani, Tiziana, D’Alessio, Antonio, Personeni, Nicola, Rimassa, Lorenza, Daly, Ann K., Scheiner, Bernhard, Pomej, Katharina, Kirstein, Martha M., Vogel, Arndt, Peck-Radosavljevic, Markus, Hucke, Florian, Finkelmeier, Fabian, Waidmann, Oliver, Trojan, Jörg, Schulze, Kornelius, Wege, Henning, Koch, Sandra, Weinmann, Arndt, Bueter, Marco, Rössler, Fabian, Siebenhüner, Alexander, De Dosso, Sara, Mallm, Jan-Philipp, Umansky, Viktor, Jugold, Manfred, Luedde, Tom, Schietinger, Andrea, Schirmacher, Peter, Emu, Brinda, Augustin, Hellmut G., Billeter, Adrian, Müller-Stich, Beat, Kikuchi, Hiroto, Duda, Dan G., Kütting, Fabian, Waldschmidt, Dirk-Thomas, Ebert, Matthias Philip, Rahbari, Nuh, Mei, Henrik E., Schulz, Axel Ronald, Ringelhan, Marc, Malek, Nisar, Spahn, Stephan, Bitzer, Michael, Ruiz de Galarreta, Marina, Lujambio, Amaia, Dufour, Jean-Francois, Marron, Thomas U., Kaseb, Ahmed, Kudo, Masatoshi, Huang, Yi-Hsiang, Djouder, Nabil, Wolter, Katharina, Zender, Lars, Marche, Parice N., Decaens, Thomas, Pinato, David J., Rad, Roland, Mertens, Joachim C., Weber, Achim, Unger, Kristian, Meissner, Felix, Roth, Susanne, Jilkova, Zuzana Macek, Claassen, Manfred, Anstee, Quentin M., Amit, Ido, Knolle, Percy, Becher, Burkhard, Llovet, Josep M., and Heikenwalder, Mathias
- Published
- 2021
- Full Text
- View/download PDF
13. Economic performance of an accredited laboratory for cell manipulation in a public health setting.
- Author
-
Pierelli, Luca and Vacca, Michele
- Subjects
- *
STEM cell transplantation , *ECONOMIC indicators , *HEMATOPOIETIC stem cell transplantation , *HEMATOPOIETIC stem cells - Abstract
This article examines the economic performance of a certified laboratory that specializes in cell manipulation in a public health setting. The laboratory follows international standards for transplantation and related therapies to ensure high quality and patient safety. However, there are challenges in determining reimbursements for the costs associated with these standards. The authors analyze the laboratory's costs and incomes and find that it is experiencing a significant economic loss. To address this issue, the authors propose implementing charges for activities that are not economically recognized. Additionally, the article discusses the economic aspects of processing and storing autologous hematopoietic stem cell collections for transplantation. The current policies of disposing of unused products and the lack of specific reimbursement for long-term storage make processing laboratories financially unsustainable. The authors suggest that the affordability of cell therapies should be assessed using dedicated modeling strategies. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
14. Platelet-Rich Plasma for Patients with Olfactory Dysfunction: Myth or Reality? A Systematic Review
- Author
-
Moffa, Antonio, primary, Nardelli, Domiziana, additional, Giorgi, Lucrezia, additional, Di Giovanni, Simone, additional, Carnuccio, Luca, additional, Mangino, Carmen, additional, Baptista, Peter, additional, Vacca, Michele, additional, and Casale, Manuele, additional
- Published
- 2024
- Full Text
- View/download PDF
15. Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis
- Author
-
Vacca, Michele, Leslie, Jack, Virtue, Samuel, Lam, Brian Y. H., Govaere, Olivier, Tiniakos, Dina, Snow, Sophie, Davies, Susan, Petkevicius, Kasparas, Tong, Zhen, Peirce, Vivian, Nielsen, Mette Juul, Ament, Zsuzsanna, Li, Wei, Kostrzewski, Tomasz, Leeming, Diana Julie, Ratziu, Vlad, Allison, Michael E. D., Anstee, Quentin M., Griffin, Julian L., Oakley, Fiona, and Vidal-Puig, Antonio
- Published
- 2020
- Full Text
- View/download PDF
16. SMIM1 absence is associated with reduced energy expenditure and excess weight
- Author
-
Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor, Jensen, Bitten Aagaard, Kaspersen, Katrine, Kjerulff, Bertram Dalskov, Kogelman, Lisette, Hørup Larsen, Margit Anita, Louloudis, Ioannis, Lundgaard, Agnete, Susan, Mikkelsen, Christina, Nissen, Ioanna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Henriksen, Alexander Pil, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Stefansson, Kari, Stefánsson, Hreinn, Sørensen, Erik, þorsteinsdóttir, Unnur, Thørner, Lise Wegner, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Katie Chan, Kei Hang, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Loz, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V.R., Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P., Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Southam, Lorraine, Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J.L., Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J.C., Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M. Arfan, Johnson, W. Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R.H.J., Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, Van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Goncalo R., Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Ida Chen, Yii-Der, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, Janaka de Silva, H., Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J. Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L.R., Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J.F., Magnusson, Patrik K.E., Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N.A., Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P. Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I.A., Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E. Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G.M., Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C.J., Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Võsa, Urmo, Burling, Keith, Walker, Lindsay, Ord, John, Barker, Peter, Warner, James, Frary, Amy, Renhstrom, Karola, Ashford, Sofie E., Piper, Jo, Biggs, Gail, Erber, Wendy N., Hoffman, Gary J., Schoenmakers, Nadia, Rieneck, Klaus, Dziegiel, Morten H., Azzu, Vian, Vacca, Michele, Aparicio, Hugo Javier, Hui, Qin, Cho, Kelly, Sun, Yan V., Wilson, Peter W., Bayraktar, Omer A., Vidal-Puig, Antonio, Ostrowski, Sisse R., Astle, William J., Olsson, Martin L., Storry, Jill R., Pedersen, Ole B., Ouwehand, Willem H., Chatterjee, Krishna, Vuckovic, Dragana, and Frontini, Mattia
- Published
- 2024
- Full Text
- View/download PDF
17. Oxidised serum peptidome characterises metabolic dysfunction-associated steatotic liver disease.
- Author
-
Mocciaro, Gabriele, George, Amy, Allison, Michael, Frontini, Mattia, Huang-Doran, Isabel, Gribble, Fiona, Reiman, Frank, Vidal-Puig, Antonio, Griffin, Julian, Azzu, Vian, Kay, Richard, and Vacca, Michele
- Published
- 2024
- Full Text
- View/download PDF
18. Effects of growth hormone-releasing hormone gene targeted ablation on ghrelin-induced feeding
- Author
-
Recinella, Lucia, Leone, Sheila, Ferrante, Claudio, Chiavaroli, Annalisa, Shohreh, Rugia, Di Nisio, Chiara, Vacca, Michele, Orlando, Giustino, Salvatori, Roberto, and Brunetti, Luigi
- Published
- 2017
- Full Text
- View/download PDF
19. Emotional disorders induced by Hemopressin and RVD-hemopressin(α) administration in rats
- Author
-
Leone, Sheila, Recinella, Lucia, Chiavaroli, Annalisa, Martinotti, Sara, Ferrante, Claudio, Mollica, Adriano, Macedonio, Giorgia, Stefanucci, Azzurra, Dvorácskó, Szabolcs, Tömböly, Csaba, De Petrocellis, Luciano, Vacca, Michele, Brunetti, Luigi, and Orlando, Giustino
- Published
- 2017
- Full Text
- View/download PDF
20. Anorexigenic effects induced by RVD-hemopressin(α) administration
- Author
-
Ferrante, Claudio, Recinella, Lucia, Leone, Sheila, Chiavaroli, Annalisa, Di Nisio, Chiara, Martinotti, Sara, Mollica, Adriano, Macedonio, Giorgia, Stefanucci, Azzurra, Dvorácskó, Szabolcs, Tömböly, Csaba, De Petrocellis, Luciano, Vacca, Michele, Brunetti, Luigi, and Orlando, Giustino
- Published
- 2017
- Full Text
- View/download PDF
21. Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)
- Author
-
Mocciaro, Gabriele, primary, Allison, Michael, additional, Jenkins, Benjamin, additional, Azzu, Vian, additional, Huang-Doran, Isabel, additional, Herrera-Marcos, Luis Vicente, additional, Hall, Zoe, additional, Murgia, Antonio, additional, Susan, Davies, additional, Frontini, Mattia, additional, Vidal-Puig, Antonio, additional, Koulman, Albert, additional, Griffin, Julian L., additional, and Vacca, Michele, additional
- Published
- 2023
- Full Text
- View/download PDF
22. Corrigendum to: “Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆” [J Hepatol (2020) 505–515]
- Author
-
Anstee, Quentin M., primary, Darlay, Rebecca, additional, Cockell, Simon, additional, Meroni, Marica, additional, Govaere, Olivier, additional, Tiniakos, Dina, additional, Burt, Alastair D., additional, Bedossa, Pierre, additional, Palmer, Jeremy, additional, Liu, Yang-Lin, additional, Aithal, Guruprasad P., additional, Allison, Michael, additional, Yki-Järvinen, Hannele, additional, Vacca, Michele, additional, Dufour, Jean-Francois, additional, Invernizzi, Pietro, additional, Prati, Daniele, additional, Ekstedt, Mattias, additional, Kechagias, Stergios, additional, Francque, Sven, additional, Petta, Salvatore, additional, Bugianesi, Elisabetta, additional, Clement, Karine, additional, Ratziu, Vlad, additional, Schattenberg, Jörn M., additional, Valenti, Luca, additional, Day, Christopher P., additional, Cordell, Heather J., additional, and Daly, Ann K., additional
- Published
- 2023
- Full Text
- View/download PDF
23. Circulating endothelial cell (CEC) kinetic in patients with Multiple Myeloma (MM) who receive Au-HSCT (Autologous Hematopoietic Stem Cell Transplantation)
- Author
-
Annibali, Ombretta, primary, Tomarchio, Valeria, additional, Gregorj, Chiara, additional, Di Cerbo, Melania, additional, Armiento, Daniele, additional, Antonelli, Lara, additional, Vincenzi, Bruno, additional, Nobile, Carolina, additional, Vacca, Michele, additional, Tirindelli, Maria Cristina, additional, and Avvisati, Giuseppe, additional
- Published
- 2023
- Full Text
- View/download PDF
24. Correction: Genome-wide association study of non- alcoholic fatty liver and steatohepatitis in a histologically characterised cohort ( vol 73, pp 505-515 , 2020 )
- Author
-
Anstee, Quentin M., Darlay, Rebecca, Cockell, Simon, Meroni, Marica, Govaere, Olivier, Tiniakos, Dina, Burt, Alastair D., Bedossa, Pierre, Palmer, Jeremy, Liu, Yang-Lin, Aithal, Guruprasad P., Allison, Michael, Yki-Jarvinen, Hannele, Vacca, Michele, Dufour, Jean-Francois, Invernizzi, Pietro, Prati, Daniele, Ekstedt, Mattias, Kechagias, Stergios, Francque, Sven, Petta, Salvatore, Bugianesi, Elisabetta, Clement, Karine, Ratziu, Vlad, Schattenberg, Joern M., Valenti, Luca, Day, Christopher P., Cordell, Heather J., Daly, Ann K., Anstee, Quentin M., Darlay, Rebecca, Cockell, Simon, Meroni, Marica, Govaere, Olivier, Tiniakos, Dina, Burt, Alastair D., Bedossa, Pierre, Palmer, Jeremy, Liu, Yang-Lin, Aithal, Guruprasad P., Allison, Michael, Yki-Jarvinen, Hannele, Vacca, Michele, Dufour, Jean-Francois, Invernizzi, Pietro, Prati, Daniele, Ekstedt, Mattias, Kechagias, Stergios, Francque, Sven, Petta, Salvatore, Bugianesi, Elisabetta, Clement, Karine, Ratziu, Vlad, Schattenberg, Joern M., Valenti, Luca, Day, Christopher P., Cordell, Heather J., and Daly, Ann K.
- Abstract
Funding Agencies|Economic and Social Research Council
- Published
- 2023
- Full Text
- View/download PDF
25. Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study
- Author
-
Jenny, Lee, Max, Westphal, Yasaman, Vali, Jerome, Boursier, Salvatorre, Petta, Rachel, Ostroff, Leigh, Alexander, Yu, Chen, Celine, Fournier, Andreas, Geier, Sven, Francque, Kristy, Wonder, Dina, Tiniako, Pierre, Bedossa, Mike, Allison, Georgios, Papatheodoridi, Helena, Cortez-Pinto, Raluca, Pai, Jean-Francois, Dufour, Diana Julie, Leeming, Stephen, Harrison, Jeremy, Cobbold, Adriaan G, Holleboom, Hannele, Yki-Järvinen, Javier, Crespo, Mattias, Ekstedt, Guruprasad P, Aithal, Elisabetta, Bugianesi, Manuel, Romero-Gomez, Richard, Torstenson, Morten, Karsdal, Carla, Yuni, Jörn M, Schattenberg, Detlef, Schuppan, Vlad, Ratziu, Clifford, Bra, Kevin, Duffin, Koos, Zwinderman, Michael, Pavlide, Quentin M, Anstee, Patrick M, Bossuyt, Anstee, Quentin M., Daly, Ann K., Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J., Day, Christopher P., Wonders, Kristy, Missier, Paolo, Mcteer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G., Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M., Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K., Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioanni, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J., Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, Mcglinchey, Aiden, Mato, Jose M., Millet, Óscar, Dufour, Jean-Françoi, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Guldager Kring Rasmussen, Daniel, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattia, Kechagias, Stergio, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M. P., Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andrea, Trautwein, Christian, Aithal, Guruprasad P., Francis, Susan, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W., Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, Mcleod, Euan Jame, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Skalshøi Kjær, Mette, Mørch Harder, Lea, Davidsen, Peter, Mikkelsen, Lars Frii, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Dougla, Shankar, Sudha, Torstenson, Richard, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D., Billin, Andrew, Doward, Lynda, Twiss, Jame, Thakker, Paresh, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, Luca, Miele (ORCID:0000-0003-3464-0068), Jenny, Lee, Max, Westphal, Yasaman, Vali, Jerome, Boursier, Salvatorre, Petta, Rachel, Ostroff, Leigh, Alexander, Yu, Chen, Celine, Fournier, Andreas, Geier, Sven, Francque, Kristy, Wonder, Dina, Tiniako, Pierre, Bedossa, Mike, Allison, Georgios, Papatheodoridi, Helena, Cortez-Pinto, Raluca, Pai, Jean-Francois, Dufour, Diana Julie, Leeming, Stephen, Harrison, Jeremy, Cobbold, Adriaan G, Holleboom, Hannele, Yki-Järvinen, Javier, Crespo, Mattias, Ekstedt, Guruprasad P, Aithal, Elisabetta, Bugianesi, Manuel, Romero-Gomez, Richard, Torstenson, Morten, Karsdal, Carla, Yuni, Jörn M, Schattenberg, Detlef, Schuppan, Vlad, Ratziu, Clifford, Bra, Kevin, Duffin, Koos, Zwinderman, Michael, Pavlide, Quentin M, Anstee, Patrick M, Bossuyt, Anstee, Quentin M., Daly, Ann K., Govaere, Olivier, Cockell, Simon, Tiniakos, Dina, Bedossa, Pierre, Burt, Alastair, Oakley, Fiona, Cordell, Heather J., Day, Christopher P., Wonders, Kristy, Missier, Paolo, Mcteer, Matthew, Vale, Luke, Oluboyede, Yemi, Breckons, Matt, Bossuyt, Patrick M., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Nieuwdorp, Max, Holleboom, Adriaan G., Verheij, Joanne, Ratziu, Vlad, Clément, Karine, Patino-Navarrete, Rafael, Pais, Raluca, Paradis, Valerie, Schuppan, Detlef, Schattenberg, Jörn M., Surabattula, Rambabu, Myneni, Sudha, Straub, Beate K., Vidal-Puig, Toni, Vacca, Michele, Rodrigues-Cuenca, Sergio, Allison, Mike, Kamzolas, Ioanni, Petsalaki, Evangelia, Campbell, Mark, Lelliott, Chris J., Davies, Susan, Orešič, Matej, Hyötyläinen, Tuulia, Mcglinchey, Aiden, Mato, Jose M., Millet, Óscar, Dufour, Jean-Françoi, Berzigotti, Annalisa, Masoodi, Mojgan, Pavlides, Michael, Harrison, Stephen, Neubauer, Stefan, Cobbold, Jeremy, Mozes, Ferenc, Akhtar, Salma, Olodo-Atitebi, Seliat, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Andersson, Anneli, Wigley, Ioan, Romero-Gómez, Manuel, Gómez-González, Emilio, Ampuero, Javier, Castell, Javier, Gallego-Durán, Rocío, Fernández, Isabel, Montero-Vallejo, Rocío, Karsdal, Morten, Guldager Kring Rasmussen, Daniel, Leeming, Diana Julie, Sinisi, Antonia, Musa, Kishwar, Sandt, Estelle, Tonini, Manuela, Bugianesi, Elisabetta, Rosso, Chiara, Armandi, Angelo, Marra, Fabio, Gastaldelli, Amalia, Svegliati, Gianluca, Boursier, Jérôme, Francque, Sven, Vonghia, Luisa, Driessen, Ann, Ekstedt, Mattia, Kechagias, Stergio, Yki-Järvinen, Hannele, Porthan, Kimmo, Arola, Johanna, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Rodrigues, Cecilia M. P., Valenti, Luca, Pelusi, Serena, Petta, Salvatore, Pennisi, Grazia, Miele, Luca, Geier, Andrea, Trautwein, Christian, Aithal, Guruprasad P., Francis, Susan, Hockings, Paul, Schneider, Moritz, Newsome, Philip, Hübscher, Stefan, Wenn, David, Rosenquist, Christian, Trylesinski, Aldo, Mayo, Rebeca, Alonso, Cristina, Duffin, Kevin, Perfield, James W., Chen, Yu, Yunis, Carla, Tuthill, Theresa, Harrington, Magdalena Alicia, Miller, Melissa, Chen, Yan, Mcleod, Euan Jame, Ross, Trenton, Bernardo, Barbara, Schölch, Corinna, Ertle, Judith, Younes, Ramy, Oldenburger, Anouk, Ostroff, Rachel, Alexander, Leigh, Biegel, Hannah, Skalshøi Kjær, Mette, Mørch Harder, Lea, Davidsen, Peter, Mikkelsen, Lars Frii, Balp, Maria-Magdalena, Brass, Clifford, Jennings, Lori, Martic, Miljen, Löffler, Jürgen, Applegate, Dougla, Shankar, Sudha, Torstenson, Richard, Fournier-Poizat, Céline, Llorca, Anne, Kalutkiewicz, Michael, Pepin, Kay, Ehman, Richard, Horan, Gerald, Ho, Gideon, Tai, Dean, Chng, Elaine, Patterson, Scott D., Billin, Andrew, Doward, Lynda, Twiss, Jame, Thakker, Paresh, Landgren, Henrik, Lackner, Carolin, Gouw, Annette, Hytiroglou, Prodromos, and Luca, Miele (ORCID:0000-0003-3464-0068)
- Abstract
Background and aims: Detecting NASH remains challenging, while at-risk NASH (steatohepatitis and F≥ 2) tends to progress and is of interest for drug development and clinical application. We developed prediction models by supervised machine learning techniques, with clinical data and biomarkers to stage and grade patients with NAFLD. Approach and results: Learning data were collected in the Liver Investigation: Testing Marker Utility in Steatohepatitis metacohort (966 biopsy-proven NAFLD adults), staged and graded according to NASH CRN. Conditions of interest were the clinical trial definition of NASH (NAS ≥ 4;53%), at-risk NASH (NASH with F ≥ 2;35%), significant (F ≥ 2;47%), and advanced fibrosis (F ≥ 3;28%). Thirty-five predictors were included. Missing data were handled by multiple imputations. Data were randomly split into training/validation (75/25) sets. A gradient boosting machine was applied to develop 2 models for each condition: clinical versus extended (clinical and biomarkers). Two variants of the NASH and at-risk NASH models were constructed: direct and composite models.Clinical gradient boosting machine models for steatosis/inflammation/ballooning had AUCs of 0.94/0.79/0.72. There were no improvements when biomarkers were included. The direct NASH model produced AUCs (clinical/extended) of 0.61/0.65. The composite NASH model performed significantly better (0.71) for both variants. The composite at-risk NASH model had an AUC of 0.83 (clinical and extended), an improvement over the direct model. Significant fibrosis models had AUCs (clinical/extended) of 0.76/0.78. The extended advanced fibrosis model (0.86) performed significantly better than the clinical version (0.82). Conclusions: Detection of NASH and at-risk NASH can be improved by constructing independent machine learning models for each component, using only clinical predictors. Adding biomarkers only improved the accuracy of fibrosis.
- Published
- 2023
26. Increased locomotor and thermogenic activity in mice with targeted ablation of the GHRH gene
- Author
-
Leone, Sheila, Chiavaroli, Annalisa, Shohreh, Rugia, Ferrante, Claudio, Ricciuti, Adriana, Manippa, Fabio, Recinella, Lucia, Di Nisio, Chiara, Orlando, Giustino, Salvatori, Roberto, Vacca, Michele, and Brunetti, Luigi
- Published
- 2015
- Full Text
- View/download PDF
27. Behavioural phenotyping of male growth hormone-releasing hormone (GHRH) knockout mice
- Author
-
Leone, Sheila, Shohreh, Rugia, Manippa, Fabio, Recinella, Lucia, Ferrante, Claudio, Orlando, Giustino, Salvatori, Roberto, Vacca, Michele, and Brunetti, Luigi
- Published
- 2014
- Full Text
- View/download PDF
28. Central venous catheter insertion in peripheral blood hematopoietic stem cell sibling donors: The SIdEM (Italian Society of Hemapheresis and Cell Manipulation) point of view
- Author
-
Vacca, Michele, Perseghin, Paolo, Accorsi, Patrizia, and Pierelli, Luca
- Published
- 2014
- Full Text
- View/download PDF
29. Pericardial Adipose Tissue Regulates Granulopoiesis, Fibrosis, and Cardiac Function After Myocardial Infarction
- Author
-
Horckmans, Michael, Bianchini, Mariaelvy, Santovito, Donato, Megens, Remco T.A., Springael, Jean-Yves, Negri, Irene, Vacca, Michele, Di Eusanio, Marco, Moschetta, Antonio, Weber, Christian, Duchene, Johan, and Steffens, Sabine
- Published
- 2018
- Full Text
- View/download PDF
30. Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption
- Author
-
Sanders, Francis W. B., Acharjee, Animesh, Walker, Celia, Marney, Luke, Roberts, Lee D., Imamura, Fumiaki, Jenkins, Benjamin, Case, Jack, Ray, Sumantra, Virtue, Samuel, Vidal-Puig, Antonio, Kuh, Diana, Hardy, Rebecca, Allison, Michael, Forouhi, Nita, Murray, Andrew J., Wareham, Nick, Vacca, Michele, Koulman, Albert, and Griffin, Julian L.
- Published
- 2018
- Full Text
- View/download PDF
31. The 'Hemolysis Model' for the Study of Cyto-Toxicity and Cyto-Protection by Bile Salts and Phospholipids
- Author
-
Portincasa, Piero, Moschetta, Antonio, Petruzzelli, Michele, Vacca, Michele, Krawczyk, Marcin, Minerva, Francesco, Palmieri, Vincenzo O., Palasciano, Giuseppe, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Cicco, Giuseppe, editor, Bruley, Duane F., editor, Ferrari, Marco, editor, and Harrison, David K., editor
- Published
- 2006
- Full Text
- View/download PDF
32. Effects of isolated GH deficiency on adipose tissue, feeding and adipokines in mice
- Author
-
Recinella, Lucia, Shohreh, Rugia, Salvatori, Roberto, Orlando, Giustino, Vacca, Michele, and Brunetti, Luigi
- Published
- 2013
- Full Text
- View/download PDF
33. Age-related changes in basal substrate oxidation and visceral adiposity and their association with metabolic syndrome
- Author
-
Siervo, Mario, Lara, Jose, Celis-Morales, Carlos, Vacca, Michele, Oggioni, Clio, Battezzati, Alberto, Leone, Alessandro, Tagliabue, Anna, Spadafranca, Angela, and Bertoli, Simona
- Published
- 2016
- Full Text
- View/download PDF
34. Metabolic dysfunction and cancer in HCV: Shared pathways and mutual interactions
- Author
-
Leslie, Jack, primary, Geh, Daniel, additional, Elsharkawy, Ahmed M., additional, Mann, Derek A., additional, and Vacca, Michele, additional
- Published
- 2022
- Full Text
- View/download PDF
35. Non-alcoholic fatty liver disease features a reduced reverse polyunsaturated fatty acid transport (free fatty acids/high-density lipoprotein) from the periphery to the liver
- Author
-
Mocciaro, Gabriele, primary, Allison, Michael, additional, Jenkins, Benjamin, additional, Azzu, Vian, additional, Huang-Doran, Isabel, additional, Kay, Richard, additional, Murgia, Antonio, additional, Susan, Davies, additional, Frontini, Mattia, additional, Vidal-Puig, Antonio, additional, Koulman, Albert, additional, Griffin, Julian L., additional, and Vacca, Michele, additional
- Published
- 2022
- Full Text
- View/download PDF
36. Is there a murine model that fully recapitulates human NASH? An unbiased bioinformatics approach to rank pre-clinical models based on proximity to human disease
- Author
-
Vacca, Michele, primary, Kamzolas, Ioannis, additional, Harder, Lea Mørch, additional, Oakley, Fiona, additional, Trautwein, Christian, additional, Hatting, Maximilian, additional, Ross, Trenton, additional, Bernardo, Barbara, additional, Oldenburger, Anouk, additional, Hjuler, Sara Toftegaard, additional, Ksiazek, Iwona, additional, Linden, Daniel, additional, Schuppan, Detlef, additional, Rodriguez-Cuenca, Sergio, additional, Tonini, Maria Manuela, additional, Kannt, Aimo, additional, Rodriguez-Castaneda, Tamara, additional, Rodrigues, Cecília M.P, additional, Cockell, Simon, additional, Govaere, Olivier, additional, Daly, Ann K., additional, Allison, Michael, additional, de Lichtenberg, Kristian Honnens, additional, Kim, Yong Ook, additional, Lindblom, Anna, additional, Oldham, Stephanie, additional, Andréasson, Anne-Christine, additional, Schlerman, Franklin, additional, Marioneaux, Jonathon, additional, Sanyal, Arun, additional, Afonso, Marta B., additional, Rinaldi, Anthony, additional, Amano, Yuichiro, additional, Paradis, Valérie, additional, Burt, Alastair, additional, Susan, Davies, additional, Driessen, Ann, additional, Yashiro, Hiroaki, additional, Brosnan, M.Juli, additional, Yunis, Carla, additional, Bedossa, Pierre, additional, Tiniakos, Dina, additional, Anstee, Quentin, additional, Petsalaki, Evangelia, additional, Davidsen, Peter, additional, Perfield, Jim, additional, and Vidal-Puig, Antonio, additional
- Published
- 2022
- Full Text
- View/download PDF
37. Transcriptomic analysis confirms that PNPLA3 I148M variant is associated with impaired mitochondrial function and antioxidant response in 3D cultured human hepatic stellate cells and liver tissue of patients with NAFLD
- Author
-
Caon, Elisabetta, primary, Martins, Maria, additional, Thanapirom, Kessarin, additional, Levi, Ana, additional, Al-Akkad, Walid, additional, Abu-Hanna, Jeries, additional, Juhl, Pernille, additional, Villesen, Ida, additional, Leeming, Diana, additional, Baselli, Guido Alessandro, additional, Taanman, Jan-Willem, additional, Vacca, Michele, additional, Valenti, Luca, additional, Romeo, Stefano, additional, Mazza, Giuseppe, additional, Pinzani, Massimo, additional, and Rombouts, Krista, additional
- Published
- 2022
- Full Text
- View/download PDF
38. Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome
- Author
-
Mocciaro, Gabriele, primary, D’Amore, Simona, additional, Jenkins, Benjamin, additional, Kay, Richard, additional, Murgia, Antonio, additional, Herrera-Marcos, Luis Vicente, additional, Neun, Stefanie, additional, Sowton, Alice P., additional, Hall, Zoe, additional, Palma-Duran, Susana Alejandra, additional, Palasciano, Giuseppe, additional, Reimann, Frank, additional, Murray, Andrew, additional, Suppressa, Patrizia, additional, Sabbà, Carlo, additional, Moschetta, Antonio, additional, Koulman, Albert, additional, Griffin, Julian L., additional, and Vacca, Michele, additional
- Published
- 2022
- Full Text
- View/download PDF
39. Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease
- Author
-
Govaere, Olivier, Kragh Petersen, Sine, Martinez-Lopez, Nuria, Wouters, Jasper, Van Haele, Matthias, Mancina, Rosellina M., Jamialahmadi, Oveis, Bilkei-Gorzo, Orsolya, Bel Lassen, Pierre, Darlay, Rebecca, Peltier, Julien, Palmer, Jeremy M., Younes, Ramy, Tiniakos, Dina, Aithal, Guruprasad P., Allison, Michael, Vacca, Michele, Berlinguer-Palmini, Rolando, Clark, James E., Drinnan, Michael J., Dufour, Jean-Francois, Ekstedt, Mattias, Francque, Sven, Petta, Salvatore, Bugianesi, Elisabetta, Day, Christopher P., Cordell, Heather J., Topal, Baki, Romeo, Stefano, Ratziu, Vlad, Roskams, Tania, Daly, Ann K., Anstee, Quentin M., and Trost, Matthias
- Subjects
macrophages, immunometabolism, NASH, inflammation - Abstract
Background & Aims: Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of macrophage scavenger receptor 1 (MSR1, CD204) remains incompletely understood. Methods: 170 NAFLD liver biopsies were processed for transcriptomic analysis and correlated with clinicopathological features. Msr1-/- and WT mice were submitted to a 16 week high-fat and high-cholesterol diet. Therapeutic intervention with monoclonal antibody against MSR1 was performed in mice and ex vivo human liver slices. Genetic susceptibility was assessed using GWAS data from 1,483 NAFLD patients and 430,101 participants of the UKBiobank. Results: MSR1 expression was associated with the occurrence of hepatic lipid-laden foamy macrophages and correlated with the degree of steatosis and steatohepatitis in NAFLD patients. Mice lacking Msr1 were protected against diet-induced metabolic disorder, showing fewer hepatic foamy macrophages, less hepatic inflammation, improved dyslipidemia and glucose tolerance, while showing altered hepatic lipid metabolism. MSR1 induced a pro-inflammatory response via the JNK signalling pathway upon triggering by saturated fatty acids. In vitro blockade of the receptor prevented the accumulation of lipids in primary macrophages which inhibited the switch towards a pro-inflammatory phenotype and the release of cytokines such as TNF-?. Targeting MSR1 using monoclonal antibody therapy in an obesity-associated NAFLD mouse model and human liver slices resulted in the prevention of foamy macrophage formation and inflammation. Moreover, we identified that rs41505344, a polymorphism in the upstream transcriptional region of MSR1, was associated with altered serum triglycerides and aspartate transaminase levels in a cohort of over 400,000 patients. Conclusions: Taken together, our data suggest a critical role for MSR1 in lipid-induced inflammation and a potential therapeutic target for the treatment of NAFLD.
- Published
- 2022
40. Circulating Endothelial Cell Kinetic in Patients with Multiple Myeloma Who Receive Autologous Hematopoietic Stem Cell Transplantation.
- Author
-
Annibali, Ombretta, Tomarchio, Valeria, Gregorj, Chiara, Di Cerbo, Melania, Armiento, Daniele, Antonelli, Lara, Vincenzi, Bruno, Nobile, Carolina, Vacca, Michele, Tirindelli, Maria Cristina, and Avvisati, Giuseppe
- Subjects
STEM cell transplantation ,HEMATOPOIETIC stem cell transplantation ,MULTIPLE myeloma ,ENDOTHELIAL cells ,MONOCLONAL gammopathies ,PLASMACYTOMA - Abstract
Introduction: Neoangiogenesis has a crucial role in multiple myeloma (MM), and circulating endothelial cells (CECs) contribute to neovascularization by inducing tumor progression and metastasis and by repairing damage to bone marrow vasculature after stem cell transplantation (HSC). We recently proved in a national multicenter study the possibility to reach a high-level standardization in CEC count and analysis based on a polychromatic flow cytometry Lyotube (BD). Our study aimed at assessing the kinetics of CECs in patients with MM undergoing autologous hematopoietic stem cell transplantation (Au-HSCT). Methods: Blood samples for analysis were collected at different time points before (T0, T1) and after (T2, T3, T4) Au-HSCT. For each sample, 20 × 10
6 leukocytes were processed as already described (Lanuti 2016 e 2018) through a multistep procedure. CECs were eventually identified as 7-ADDneg/Syto16pos/CD45neg/CD34pos/CD146pos. Results: Twenty-six MM patients were enrolled in the study. Overall, we observed a constant increase of CECs values from T0 to T3 (day of neutrophil engraftment) followed by decrease at T4 (100 days after transplantation). Using the median value of CECs at T3, we could define a cut-off concentration of 618/mL, with patients with more infective complications having CECs above that value (9/13 vs. 2/13; p = 0.005). Conclusion: CECs value may be a function of endothelial damage caused by conditioning regimen, as suggested by the increase of their level during the engraftment period. A more severe endothelial damage is reflected by the increase of infective complications in patients with higher CECs value at T3. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
41. Poor mobilizer: A retrospective study on proven and predicted incidence according to GITMO criteria
- Author
-
Piccirillo, Nicola, Vacca, Michele, Lanti, Alessandro, Ipsevich, Francesco, Maresca, Maddalena, Fiorelli, Elena, Bianchi, Maria, Adorno, Gaspare, Pierelli, Luca, Majolino, Ignazio, Leone, Giuseppe, and Zini, Gina
- Published
- 2012
- Full Text
- View/download PDF
42. Global multi-stakeholder endorsement of the MAFLD definition
- Author
-
Abate, Maria Lorena, Abbas, Bahaa, Abbassy, Ahmed Amr, Abd El Ghany, Waleed, Abd Elkhalek, Amira, Abd ElMajeed, Emad, Abdalgaber, Mohammad, AbdAllah, Mohamed, Abdallah, Marwa, Abdallah, Nourhan, Abdelaleem, Shereen, Abdelghani, Yasser, Abdelghany, Wael, Abdelhalim, Safaa Mohamed, Abdelhamid, Wafaa, Abdelhamid, Nehal, Abdelkader, Nadia A., Abdelkreem, Elsayed, Abdelmohsen, Aly Mohamed, Abdelrahman, Awny Ali, Abd-elsalam, Sherief M, Abdeltawab, Doaa, Abduh, Abdulbaset, Abdulhakam, Nada, Abdulla, Maheeba, Abedpoor, Navid, Abenavoli, Ludovico, Åberg, Fredrik, Ablack, Omala, Abo elftouh, Mostafa, Abo-Amer, Yousry Esam-Eldin, Aboubkr, Ashraf, Aboud, Alaa, Abouelnaga, Amr M., Aboufarrag, Galal A., Aboutaleb, Ashraf, Abundis, Leticia, Adalı, Gupse, Adames, Enrique, Adams, Leon, Adda, Danjuma, Adel, Noor, Adel, Nada, Adel Sayed, Muhammad, Afaa, Taiba Jibril, Afredj, Nawal, Aghayeva, Gulnara, Aghemo, Alessio, Aguilar-Salinas, Carlos A., Ahlenstiel, Golo, Ahmady, Walid, Ahmed, Wafaa, Ahmed, Amira, Ahmed, Samah Nasser, Ahmed, Heba Mostafa, Ahmed, Rasha, Aigner, Elmar, Akarsu, Mesut, Akroush, Maisam, Akyuz, Umit, Al Mahtab, Mamun, Al Qadiri, Tahani, Al Rawahi, Yusriya, AL rubaee, Razzaq, Al Saffar, Muna, Alam, Shahinul, Al-Ani, Zaid, Albillos, Agustín, Alboraie, Mohamed, Al-Busafi, Said, Al-Emam, Mohamed, Alharthi, Jawaher, Ali, Kareem, Ali, Basma Abdelmoez, Ali, Mohammad, Ali, Raja Affendi Raja, Alisi, Anna, AL-Khafaji, Ali Raad, Alkhatry, Maryam, Aller, Rocio, Almansoury, Yahya, Al-Naamani, Khalid, Alnakeeb, Alaa, Alonso, Anna, Alqahtani, Saleh A., Alrabadi, Leina, Alswat, Khalid, Altaher, Mahir, Altamimi, Turki, Altamirano, Jose, Alvares-da-Silva, Mario R., Aly, Elsragy Adel M., Alzahaby, Amgad, Alzamzamy, Ahmed, Amano, Keisuke, Amer, Maysa A., Amin, Mona A., Amin, Sayed A., Amir, Ashraf A., Ampuero, Javier, Anas, Noha, Andreone, Pietro, Andriamandimby, Soa Fy, Anees, Mahmoud, Angela, Peltec, Antonios, Manal, Arafat, Wael, Araya, Jose Moreno, Armendariz-Borunda, Juan, Armstrong, Matthew J., Ashktorab, Hassan, Aspichueta, Patricia, Assal, Fathia, Atef, Mira, Attia, Dina, Atwa, Hoda, Awad, Reham, Awad, Mohyeldeen Abd Elaziz, Awny, Sally, Awolowo, Obafemi, Awuku, Yaw Asante, Ayada, Ibrahim, Aye, Than Than, Ayman, Sherif, Ayman, Hedy, Ayoub, Hesham, Azmy, Hosny M., Babaran, Romiro P., Badreldin, Omneya, Badry, Ahmed, Bahçecioğlu, İbrahim Halil, Bahour, Amira, Bai, Jiajia, Balaban, Yasemin, Balasubramanyam, Muthuswamy, Bamakhrama, Khaled, Banales, Jesus M, Bangaru, Babu, Bao, Jianfeng, Barahona, Jorge Suazo, Barakat, Salma, Barbalho, Sandra Maria, Barbra, Bikwa, Barranco, Beatriz, Barrera, Francisco, Baumann, Ulrich, Bazeed, Shamardan, Bech, Eva, Benayad, Aourarh, Benesic, Andreas, Bernstein, David, Bessone, Fernando, Birney, Susie, Bisseye, Cyrille, Blake, Martin, Bobat, Bilal, Bonfrate, Leonilde, Bordin, Dmitry S, Bosques-Padilla, Francisco, Boursier, Jerome, Boushab, Boushab Mohamed, Bowen, David, Bravo, Patricia Medina, Brennan, Paul N, Bright, Bisi, Broekaert, Ilse, Buque, Xabier, Burgos-Santamaría, Diego, Burman, Julio, Busetto, Luca, Byrne, Chris D., Cabral-Prodigalidad, Patricia Anne I., Cabrera-Alvarez, Guillermo, Cai, Wei, Cainelli, Francesca, Caliskan, Ali Riza, Canbay, Ali, Cano-Contreras, Ana, Cao, Hai-Xia, Cao, Zhujun, Carrion, Andres, Carubbi, Francesca, Casanovas, Teresa, Castellanos Fernández, Marlen Ivón, Chai, Jin, Chan, Siew Pheng, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chayama, Kazuaki, Chen, Jinjun, Chen, Lin, Chen, Zhong-Wei, Chen, Huiting, Chen, Sui-Dan, Chen, Qiang, Chen, Yaxi, Chen, Gang, Chen, En-Quang, Chen, Fei, Chen, Pei-Jer, Cheng, Robert, Cheng, Wendy, Chieh, Jack Tan Wei, Chokr, Imad, Cholongitas, Evangelos, Choudhury, Ashok, Chowdhury, Abhijit, Chukwudike, Evaristus Sunday, Ciardullo, Stefano, Clayton, Michelle, Clement, Karine, Cloa, Marie Michelle, Coccia, Cecilia, Collazos, Cristina, Colombo, Massimo, Cosar, Arif Mansur, Cotrim, Helma Pinchemel, Couillerot, Joris, Coulibaly, Alioune, Crespo, Gonzalo, Crespo, Javier, Cruells, Maria, Cua, Ian Homer Y., Dabbous, Hesham K., Dalekos, George N, D'Alia, Patricia, Dan, Li, Dao, Viet Hang, Darwish, Mostafa, Datz, Christian, Davalos-Moscol, Milagros B, Dawoud, Heba, de Careaga, Blanca Olaechea, de Knegt, Robert, de Ledinghen, Victor, de Silva, Janaka, Debzi, Nabil, Decraecker, Marie, Del Pozo, Elvira, Delgado, Teresa C, Delgado-Blanco, Manuel, Dembiński, Łukasz, Depina, Adilson, Derbala, Moutaz, Desalegn, Hailemichael, Desbois-Mouthon, Christèle, Desoky, Mahmoud, Dev, Anouk, Di Ciaula, Agostino, Diago, Moisés, Diallo, Ibrahima, Díaz, Luis Antonio, Dirchwolf, Melisa, Dongiovanni, Paola, Dorofeyev, Andrriy, Dou, Xiaoguang, Douglas, Mark W., Doulberis, Michael, Dovia, Cecil K., Doyle, Adam, Dragojević, Ivana, Drenth, Joost PH, Duan, Xuefei, Dulskas, Audrius, Dumitrascu, Dan L, Duncan, Oliver, Dusabejambo, Vincent, Dwawhi, Rev. Shem N.A., Eiketsu, Sho, El Amrousy, Doaa, El Deeb, Ahmed, El Deriny, Ghada, El Din, Hesham Salah, El Kamshishy, Salwa, El Kassas, Mohamed, El Raziky, Maissa, Elagamy, Osama A, Elakel, Wafaa, Elalfy, Dina, Elaraby, Hanaa, ElAwady, Heba, Elbadawy, Reda, Eldash, Hanaa Hassan, Eldefrawy, Manal S., Elecharri, Carol Lezama, Elfaramawy, Amel, Elfatih, Mohammed, Elfiky, Mahmoud, Elgamsy, Mohamed, Elgendy, Mohamed, El-Guindi, Mohamed A., Elhussieny, Nagi, Eliwa, Ahmed Maher, Elkabbany, Zeineb, El-Khayat, Hesham, El-Koofy, Nehal M., Elmetwalli, Alaa, Elrabat, Amr, El-Raey, Fathiya, Elrashdy, Fatma, Elsahhar, Medhat, Elsaid, Esraa M., Elsayed, Shimaa, Elsayed, Hany, Elsayed, Aly, Elsayed, Amr M., Elsayed, Hamdy, El-Serafy, Magdy, Elsharkawy, Ahmed M., Elsheemy, Reem Yehia, Elshemy, Eman Elsayed, Elsherbini, Sara, Eltoukhy, Naglaa, Elwakil, Reda, Emad, Ola, Emad, Shaimaa, Embabi, Mohamed, Ergenç, Ilkay, Ermolova, Tatiana, Esmat, Gamal, Esmat, Doaa M., Estupiñan, Enrique Carrera, Ettair, Said, Eugen, Tcaciuc, Ezz-Eldin, Mohammed, Falcón, Lidia Patricia Valdivieso, Fan, Yu-Chen, Fandari, Samah, Farag, Mahmoud, Farahat, Taghreed Mohamed, Fares, Eman M., Fares, Michael, Fassio, Eduardo, Fathy, Hayam, Fathy, Dina, Fathy, Wael, Fayed, Soheir, Feng, Dan, Feng, Gong, Fernández-Bermejo, Miguel, Ferreira, Cristina Targa, Ferrer, Javier Díaz, Forbes, Alastair, Fouad, Rabab, Fouad, Hanan M., Frisch, Tove, Fujii, Hideki, Fukunaga, Shuhei, Fukunishi, Shinya, Fulya, Hacer, Furuhashi, Masato, Gaber, Yasmine, Galang, Augusto Jose G., Gallardo, Jacqueline Cordova, Galloso, Rocío, Gamal, Mahmoud, Gamal, Reham, Gamal, Hadeel, Gan, Jian, Ganbold, Anar, Gao, Xin, Garas, George, Garba, Tony, García-Cortes, Miren, García-Monzón, Carmelo, García-Samaniego, Javier, Gastaldelli, Amalia, Gatica, Manuel, Gatley, Elizabeth, Gegeshidze, Tamar, Geng, Bin, Ghazinyan, Hasmik, Ghoneem, Salma, Giacomelli, Luca, Giannelli, Gianluigi, Giannini, Edoardo G., Giefer, Matthew, Ginès, Pere, Girala, Marcos, Giraudi, Pablo J, Goh, George Boon-Bee, Gomaa, Ahmed Ali, Gong, Benbingdi, Gonzales, Dina Hilda C., Gonzalez, Humberto C., Gonzalez-Huezo, Maria Saraí, Graupera, Isabel, Grgurevic, Ivica, Grønbæk, Henning, Gu, Xuelian, Guan, Lin, Gueye, Ibrahima, Guingané, Alice Nanelin, Gul, Ozen Oz, Gul, Cuma Bulent, Guo, Qing, Gupta, Pramendra Prasad, Gurakar, Ahmet, Gutierrez, Juan Carlos Restrepo, Habib, Ghada, Hafez, Azaa, Hagman, Emilia, Halawa, Eman, Hamdy, Osama, Hamed, Abd Elkhalek, Hamed, Dina H., Hamid, Saeed, Hamoudi, Waseem, Han, Yu, Haridy, James, Haridy, Hanan, Harris, David C H Harris, Hart, Michael, Hasan, Fuad, Hashim, Almoutaz, Hassan, Israa, Hassan, Ayman, Hassan, Essam Ali, Hassan, Adel Ahmed, Hassan, Magda Shehata, Hassanin, Fetouh, Hassnine, Alshymaa, Haukeland, John Willy, Hawal, Amr Ismael M., He, Jinfan, He, Qiong, He, Yong, He, Fang-Ping, Hegazy, Mona, Hegazy, Adham, Henegil, Osama, Hernández, Nelia, Hernández-Guerra, Manuel, Higuera-de-la-Tijera, Fatima, Hindy, Ibrahim, Hirota, Keisuke, Ho, Lee Chi, Hodge, Alexander, Hosny, Mohamed, Hou, Xin, Huang, Jiao-Feng, Huang, Yan, Huang, Zhifeng, Huang, Yuan, Huang, Ang, Huang, Xiao-Ping, Hui-ping, Sheng, Hunyady, Bela, Hussein, Mennatallah A., Hussein, Osama, Hussien, Shahinaz Mahmoud, Ibáñez-Samaniego, Luis, Ibdah, Jamal, Ibrahim, Luqman, Ibrahim, Miada, Ibrahim, Ibrahim, Icaza-Chávez, Maria E., Idelbi, Sahar, Idilman, Ramazan Idilman, Ikeda, Mayumi, Indolfi, Giuseppe, Invernizzi, Federica, Irshad, Iram, Isa, Hasan Mohamed Ali, Iskandar, Natacha Jreige, Ismaiel, Abdulrahman, Ismail, Mariam, Ismail, Zulkifli, Ismail, Faisal, Iwamoto, Hideki, Jack, Kathryn, Jacob, Rachael, Jafarov, Fuad, Jafri, Wasim, Jahshan, Helen, Jalal, Prasun K, Jancoriene, Ligita, Janicko, Martin, Jayasena, Hiruni, Jefferies, Meryem, Jha, Vivekanand, Ji, Fanpu, Ji, Yaqiu, Jia, Jidong, Jiang, Changtao, Jiang, Ni, Jiang, Zong-zhe, Jin, Xing, Jin, Yi, Jing, Xu, Jingyu, Qian, Jinjolava, Maia, Jong, FX Himawan Haryanto, Jucov, Alina, Julius, Ibecheole, Kaddah, Mona, Kamada, Yoshihiro, kamal, Abobakr, Kamal, Enas Mohamed, Kamel, Ashraf Sayed, Kao, Jia-Horng, Karin, Maja, Karlas, Thomas, Kashwaa, Mohammad, Katsidzira, Leolin, Kaya, Eda, Kayasseh, M.Azzam, Keenan, Bernadette, Keklikkiran, Caglayan, Keml, William, Khalaf, Deia K., Khalefa, Rofida, Khamis, Sherin, Khater, Doaa, khattab, Hamed, Khavkin, Anatoly, Khlynova, Olga, Khmis, Nabil, Kobyliak, Nazarii, Koffas, Apostolos, Koike, Kazuhiko, Kok, Kenneth Y.Y., Koller, Tomas, Komas, Narcisse Patrice, Korochanskaya, Nataliya V., Koulla, Yannoula, Koya, Shunji, Kraft, Colleen, Kraja, Bledar, Krawczyk, Marcin, Kuchay, Mohammad Shafi, Kulkarni, Anand V, Kumar, Ashish, Kumar, Manoj, Lakoh, Sulaiman, Lam, Philip, Lan, Ling, Lange, Naomi F., Lankarani, Kamran Bagheri, Lanthier, Nicolas, Lapshyna, Kateryna, Lashen, Sameh A., Laure, Konang Nguieguia Justine, Lazebnik, Leonid, Lebrec, Didier, Lee, Samuel S., Lee, Way Seah, Lee, Yeong Yeh, Leeming, Diana Julie, Leite, Nathalie Carvalho, Leon, Roberto, Lesmana, Cosmas Rinaldi Adithya, Li, Junfeng, Li, Qiong, Li, Jun, Li, Yang-Yang, Li, Yufang, Li, Lei, Li, Min, li, Yiling, Liang, Huiqing, Lijuan, Tang, Lim, Seng Gee, Lim, Lee-Ling, Lin, Shumei, Lin, Han-Chieh, Lin, Rita, Lithy, Rania, Liu, Yaru, Liu, Yuanyuan, Liu, Xin, Liu, Wen-Yue, Liu, Shourong, Liu, Ken, Liu, Tian, Lonardo, Amedeo, López, Mariana Bravo, López-Benages, Eva, Lopez-Jaramillo, Patricio, Lu, Huimin, Lu, Lun Gen, Lu, Yan, Lubel, John, Lui, Rashid, Lupasco, Iulianna, Luzina, Elena, Lv, Xiao-Hui, Lynch, Kate, Ma, Hong-Lei, Machado, Mariana Verdelho, Maduka, Nonso, Madzharova, Katerina, Magdaong, Russellini, Mahadeva, Sanjiv, Mahfouz, Amel, Mahmood, Nik Ritza Kosai Nik, Mahmoud, Eman, Mahrous, Mohamed, Maiwall, Rakhi, Majeed, Ammar, Majumdar, Avik, Mak, Loey, Maklouf, Madiha M, Malekzadeh, Reza, Mandato, Claudia, Mangia, Alessandra, Mann, Jake, Mansour, Hala Hussien, Mansouri, Abdellah, Mantovani, Alessandro, Mao, Jun qian, Maramag, Flor, Marchesini, Giulio, Marcus, Claude, Marinho, Rui António Rocha Tato, Martinez-Chantar, Maria L, Martins, Antonieta A. Soares, Marwan, Rana, Mason, Karen Frances, Masoud, Ghadeer, Massoud, Mohamed Naguib, Matamoros, Maria Amalia, Mateos, Rosa Martín, Mawed, Asmaa, Mbanya, Jean Claude, Mbendi, Charles, McColaugh, Lone, McLeod, Duncan, Medina, Juan Francisco Rivera, Megahed, Ahmed, Mehrez, Mai, Memon, Iqbal, Merat, Shahin, Mercado, Randy, Mesbah, Ahmed, Meskini, Taoufik, Metwally, Mayada, Metwaly, Rasha, Miao, Lei, Micah, Eileen, Miele, Luca, Milivojevic, Vladimir, Milovanovic, Tamara, Mina, Yvonne L., Mishkovik, Milan, Mishriki, Amal, Mitchell, Tim, Mohamed, Alshaimaa, Mohamed, Mona, Mohamed, Sofain, Mohammed, Shady, Mohammed, Ahmed, Mohan, Viswanathan, Mohie, Sara, Mokhtar, Aalaa, Moniem, Reham, Montilla, Mabel Segura, Morales, Jose Antonio Orozco, Morata, María María Sánchez, Moreno-Planas, Jose Maria, Morise, Silvia, Mosaad, Sherif, Moselhy, Mohamed, Mostafa, Alaa Mohamed, Mostafa, Ebraheem, Mouane, Nezha, Mousa, Nasser, Moustafa, Hamdy Mahfouz, Msherif, Abeer, Muller, Kate, Munoz, Christopher, Muñoz-Urribarri, Ana Beatriz, Murillo, Omar Alfaro, Mustapha, Feisul Idzwan, Muzurović, Emir, Nabil, Yehia, Nafady, Shaymaa, Nagamatsu, Ayu, Nakajima, Atsushi, Nakano, Dan, Nan, Yuemin, Nascimbeni, Fabio, Naseef, Mirella S., Nashat, Nagwa, Natalia, Taran, Negro, Francesco, Nersesov, Alexander V., Neuman, Manuela, Ng'wanasayi, Masolwa, Ni, Yan, Nicoll, Amanda, Niizeki, Takashi, Nikolova, Dafina, Ningning, Wang, Niriella, Madunil, Nogoibaeva, K.A, Nordien, Rozeena, O Sullivan, Catherine, O'Beirne, James, Obekpa, Solomon, Ocama, Ponsiano, Ochwoto, Missiani, Ogolodom, Michael Promise, Ojo, Olusegun, Okrostsvaridze, Nana, Oliveira, Claudia P., Omaña, Raul Contreras, Omar, Omneya M., Omar, Hanaa, Omar, Mabroka, Omran, Salma, Omran, Reham, Osman, Marian Muse, Owise, Nevin, Owusu-Ansah, Theobald, Padilla- Machaca, P. Martín, Palle, Sirish, Pan, Ziyan, Pan, Xiao-Yan, Pan, Qiuwei, Papaefthymiou, Apostolis, Paquissi, Feliciano Chanana, Par, Gabriella, Parkash, Arit, Payawal, Diana, Peltekian, Kevork M., Peng, Xuebin, Peng, Liang, Peng, Ying, Pengoria, Rahul, Perez, Martina, Pérez, José Luis, Pérez, Norma Marlene, Persico, Marcello, Pessoa, Mário Guimarães, Petta, Salvatore, Philip, Mathew, Plaz Torres, Maria Corina, Polavarapu, Naveen, Poniachik, Jaime, Portincasa, Piero, Pu, Chunwen, Pürnak, Tuğrul, Purwanto, Edhie, Qi, Xiaolong, Qi, Xingshun, Qian, Zibing, Qiang, Zhao, Qiao, Zengpei, Qiao, Liang, Queiroz, Alberto, Rabiee, Atoosa, Radwan, Manal, Rahetilahy, Alain Marcel, Ramadan, Yasmin, Ramadan, Dina, Ramli, Anis Safura, Ramm, Grant A., Ran, Ao, Rankovic, Ivan, RAO, Huiying, Raouf, Sara, Ray, Sayantan, Reau, Nancy, Refaat, Ahmed, Reiberger, Thomas, Remes-Troche, Jose M, Reyes, Eira Cerda, Richardson, Ben, Ridruejo, Ezequiel, Riestra Jimenez, Sergio, Rizk, Ibrahim, Roberts, Stuart, Roblero, Juan Pablo, Robles, Jorge Alberto Prado, Rockey, Don, Rodríguez, Manuel, Rodríguez Hernández, Heriberto, Román, Eva, Romeiro, Fernando Gomes, Romeo, Stefano, Rosales-Zabal, Jose Miguel, Roshdi, Georgina R., Rosso, Natalia, Ruf, Andres, Ruiz, Patricia Cordero, Runes, Nelia R., Ruzzenente, Andrea, Ryan, Marno, Saad, Ahmed, Sabbagh, Eman BE, Sabbah, Meriam, Saber, Shimaa, Sabrey, Reham, Sabry, Ramy, Saeed, Maysaa Abdallah, Said, Dina, Said, Ebada M, Sakr, Mohammad Amin, Salah, Yara, Salama, Rabab Maamoun, Salama, Asmaa, Saleh, Hussein, Saleh, Ahmed, Salem, Ahmed, Salem, Ahmed Thabet, Salifou, Alkassoum, Salih, Aso Faeq, Salman, Abdallah, Samouda, Hanen, Sanai, Faisal, Sánchez-Ávila, Juan Francisco, Sanker, Lakshumanan, Sano, Tomoya, Sanz, Miquel, Saparbu, Tobokalova, Sawhney, Rohit, Sayed, Fatma, Sayed, Sayed A., Sayed, Ashraf Othman, Sayed, Manar, Sebastiani, Giada, Secadas, Laura, Sediqi, Khawaja Qamaruddin, Seif, Sameh, Semida, Nady, Şenateş, Ebubekir, Serban, Elena Daniela, Serfaty, Lawrence, Seto, Wai-Kay, Sghaier, Ikram, Sha, Min, Shabaan, Hamada M., Shalaby, Lobna, Shaltout, Inass, Sharara, Ala I., Sharma, Vishal, Shawa, Isaac Thom, Shawkat, Ahmed, Shawky, Nehal, Shehata, Osama, Sheils, Sinead, Shewaye, Abate Bane, Shi, Guojun, Shi, Junping, Shimose, Shigeo, Shirono, Tomotake, Shou, Lan, Shrestha, Ananta, Shui, Guanghou, Sievert, William, Sigurdardottir, Solveig, Sira, Mostafa Mohamed, Siradj, Riyadh, Sison, Cecilia, Smyth, Linda, Soliman, Reham, Sollano, Jose D, Sombie, Roger, Sonderup, Mark, Sood, Siddharth, Soriano, German, Stedman, Catherine A M, Stefanyuk, Oksana, Štimac, Davor, Strasser, Simone, Strnad, Pavel, Stuart, Katherine, Su, Wen, Su, Minghua, Sumida, Yoshio, Sumie, Shuji, Sun, Dan-Qin, Sun, Jing, Suzuki, Hiroyuki, Svegliati-Baroni, Gianluca, Swar, Mohamed Osman, TAHARBOUCHT, S., Taher, Zenab, Takamura, Saori, Tan, Lin, Tan, Soek-Siam, Tanwandee, Tawesak, Tarek, Sara, Tatiana, Ghelimici, Tavaglione, Federica, Tecson, Gina Y., Tee, Hoi-Poh, Teschke, Rolf, Tharwat, Mostafa, Thong, Vo Duy, Thursz, Mark, Tine, Tulari, Tiribelli, Claudio, Tolmane, Ieva, Tong, Jing, Tongo, Marco, Torkie, Mamdouh, Torre, Aldo, Torres, Esther A, Trajkovska, Meri, Treeprasertsuk, Sombat, Tsutsumi, Tsubasa, Tu, Thomas, Tur, Josep A., Turan, Dilara, Turcan, Svetlana, Turkina, Svetlana, Tutar, Engin, Tzeuton, Christian, Ugiagbe, Rose, Uygun, Ahmet, Vacca, Michele, Vajro, Pietro, Van der Poorten, David, Van Kleef, Laurens A., Vashakidze, Eliza, Velazquez, Carlos Moctezuma, Velazquez, Mirtha Infante, Vento, Sandro, Verhoeven, Veronique, Vespasiani-Gentilucci, Umberto, Vethakkan, Shireene Ratna, Vilaseca, Josep, Vítek, Libor, Volkanovska, Ance, Wallace, Michael, Wan, Wang, Wang, Yan, Wang, Ying, Wang, Xiaolin, Wang, Xuemei, Wang, Chengyan, Wang, Chunjiong, Wang, Mingjie, Wangchuk, Pelden, Weltman, Martin, White, MaryFrances, Wiegand, Johannes, Wifi, Mohamed-Naguib, Wigg, Alan, Wilhelmi, Markus, William, Remon, Wittenburg, Henning, Wu, Shengjie, Wubeneh, Abdu Mohammed, Xia, Hongping, Xiao, Jian, Xiao, Xiao, Xiaofeng, Wang, Xiong, Wanyuan, Xu, Liang, Xu, Jie, Xu, Weiguo, Xu, Jing-Hang, Xu, Keshu, Xu, Yumin, Xu, Shi-Hao, Xu, Meng, Xu, Aimin, Xu, Chengfu, Yan, Hongmei, Yang, Jingyi, Yang, Rui-Xu, Yang, Yating, Yang, Qinhe, Yang, Naibin, Yao, Jia, Yara, Justine, Yaraş, Serkan, Yılmaz, Nimet, Younes, Ramy, younes, Huda, Young, Sona, Youssef, Farah, Yu, Yanyan, Yu, Ming-Lung, Yuan, Jing, Yue, Zhang, Yuen, Man-Fung, Yun, Wang, Yurukova, Nonka, Zakaria, Serag, Zaky, Samy, Zaldastanishvili, Maia, Zapata, Rodrigo, Zare, Nazanin, Zerem, Enver, Zeriban, Nema, Zeshuai, Xu, Zhang, Huijie, Zhang, Xuemei, Zhang, Yupei, Zhang, Wen-Hua, Zhang, Xuchen, Zhang, Yon-ping, Zhang, Yuexin, Zhang, Zhan-qing, Zhao, Jingmin, Zhao, Rong-Rong, Zhao, Hongwei, Zheng, Chao, Zheng, Yijie, Zheng, Ruidan, Zheng, Tian-Lei, Zheng, Kenneth, Zhou, Xi Qiao, Zhou, Yongjian, Zhou, Yu-Jie, Zhou, Hong, Zhou, Ling, Zhou, Yongning, Zhu, Long dong, Zhu, Yong Fen, Zhu, Yueyong, Zhu, Pei-Wu, Ziada, Ebtesam, Ziring, David, Ziyi, Li, Zou, Shanshan, Zou, Zhengsheng, Zou, Huaibin, Zuart Ruiz, Roberto, Méndez-Sánchez, Nahum, Bugianesi, Elisabetta, Gish, Robert G, Lammert, Frank, Tilg, Herbert, Nguyen, Mindie H, Sarin, Shiv K, Fabrellas, Núria, Zelber-Sagi, Shira, Fan, Jian-Gao, Shiha, Gamal, Targher, Giovanni, Zheng, Ming-Hua, Chan, Wah-Kheong, Vinker, Shlomo, Kawaguchi, Takumi, Castera, Laurent, Yilmaz, Yusuf, Korenjak, Marko, Spearman, C Wendy, Ungan, Mehmet, Palmer, Melissa, El-Shabrawi, Mortada, Gruss, Hans-Juergen, Dufour, Jean-François, Dhawan, Anil, Wedemeyer, Heiner, George, Jacob, Valenti, Luca, Fouad, Yasser, Romero‐Gomez, Manuel, and Eslam, Mohammed
- Published
- 2022
- Full Text
- View/download PDF
43. Adoptive immunotherapy with cytokine-induced killer cells generated with a new good manufacturing practice-grade protocol
- Author
-
Rutella, Sergio, Iudicone, Paola, Bonanno, Giuseppina, Fioravanti, Daniela, Procoli, Annabella, Lavorino, Claudio, Foddai, Maria Laura, Lorusso, Domenica, Martinelli, Enrica, Vacca, Michele, Ipsevich, Francesco, Nuti, Marianna, Scambia, Giovanni, and Pierelli, Luca
- Published
- 2012
- Full Text
- View/download PDF
44. Tu1305: USING A HUMAN 3-D COCULTURE SYSTEM TO EXPLORE SPTBN1 AS A THERAPEUTIC NASH TARGET
- Author
-
Gough, Nancy R., primary, Xiang, Xiyan, additional, Rao, Shuyun, additional, Yang, Xiaochun, additional, Ohshiro, Kazufumi, additional, Latham, Patricia S., additional, Jogunoori, Wilma, additional, Shetty, Kirti, additional, Vacca, Michele, additional, Vidal-Puig, Antonio, additional, Guenigault, Gareth, additional, and Mishra, Lopa, additional
- Published
- 2022
- Full Text
- View/download PDF
45. Global multi-stakeholder endorsement of the MAFLD definition
- Author
-
Méndez-Sánchez, Nahum, primary, Bugianesi, Elisabetta, additional, Gish, Robert G, additional, Lammert, Frank, additional, Tilg, Herbert, additional, Nguyen, Mindie H, additional, Sarin, Shiv K, additional, Fabrellas, Núria, additional, Zelber-Sagi, Shira, additional, Fan, Jian-Gao, additional, Shiha, Gamal, additional, Targher, Giovanni, additional, Zheng, Ming-Hua, additional, Chan, Wah-Kheong, additional, Vinker, Shlomo, additional, Kawaguchi, Takumi, additional, Castera, Laurent, additional, Yilmaz, Yusuf, additional, Korenjak, Marko, additional, Spearman, C Wendy, additional, Ungan, Mehmet, additional, Palmer, Melissa, additional, El-Shabrawi, Mortada, additional, Gruss, Hans-Juergen, additional, Dufour, Jean-François, additional, Dhawan, Anil, additional, Wedemeyer, Heiner, additional, George, Jacob, additional, Valenti, Luca, additional, Fouad, Yasser, additional, Romero‐Gomez, Manuel, additional, Eslam, Mohammed, additional, Abate, Maria Lorena, additional, Abbas, Bahaa, additional, Abbassy, Ahmed Amr, additional, Abd El Ghany, Waleed, additional, Abd Elkhalek, Amira, additional, Abd ElMajeed, Emad, additional, Abdalgaber, Mohammad, additional, AbdAllah, Mohamed, additional, Abdallah, Marwa, additional, Abdallah, Nourhan, additional, Abdelaleem, Shereen, additional, Abdelghani, Yasser, additional, Abdelghany, Wael, additional, Abdelhalim, Safaa Mohamed, additional, Abdelhamid, Wafaa, additional, Abdelhamid, Nehal, additional, Abdelkader, Nadia A., additional, Abdelkreem, Elsayed, additional, Abdelmohsen, Aly Mohamed, additional, Abdelrahman, Awny Ali, additional, Abd-elsalam, Sherief M, additional, Abdeltawab, Doaa, additional, Abduh, Abdulbaset, additional, Abdulhakam, Nada, additional, Abdulla, Maheeba, additional, Abedpoor, Navid, additional, Abenavoli, Ludovico, additional, Åberg, Fredrik, additional, Ablack, Omala, additional, Abo elftouh, Mostafa, additional, Abo-Amer, Yousry Esam-Eldin, additional, Aboubkr, Ashraf, additional, Aboud, Alaa, additional, Abouelnaga, Amr M., additional, Aboufarrag, Galal A., additional, Aboutaleb, Ashraf, additional, Abundis, Leticia, additional, Adalı, Gupse, additional, Adames, Enrique, additional, Adams, Leon, additional, Adda, Danjuma, additional, Adel, Noor, additional, Adel, Nada, additional, Adel Sayed, Muhammad, additional, Afaa, Taiba Jibril, additional, Afredj, Nawal, additional, Aghayeva, Gulnara, additional, Aghemo, Alessio, additional, Aguilar-Salinas, Carlos A., additional, Ahlenstiel, Golo, additional, Ahmady, Walid, additional, Ahmed, Wafaa, additional, Ahmed, Amira, additional, Ahmed, Samah Nasser, additional, Ahmed, Heba Mostafa, additional, Ahmed, Rasha, additional, Aigner, Elmar, additional, Akarsu, Mesut, additional, Akroush, Maisam, additional, Akyuz, Umit, additional, Al Mahtab, Mamun, additional, Al Qadiri, Tahani, additional, Al Rawahi, Yusriya, additional, AL rubaee, Razzaq, additional, Al Saffar, Muna, additional, Alam, Shahinul, additional, Al-Ani, Zaid, additional, Albillos, Agustín, additional, Alboraie, Mohamed, additional, Al-Busafi, Said, additional, Al-Emam, Mohamed, additional, Alharthi, Jawaher, additional, Ali, Kareem, additional, Ali, Basma Abdelmoez, additional, Ali, Mohammad, additional, Ali, Raja Affendi Raja, additional, Alisi, Anna, additional, AL-Khafaji, Ali Raad, additional, Alkhatry, Maryam, additional, Aller, Rocio, additional, Almansoury, Yahya, additional, Al-Naamani, Khalid, additional, Alnakeeb, Alaa, additional, Alonso, Anna, additional, Alqahtani, Saleh A., additional, Alrabadi, Leina, additional, Alswat, Khalid, additional, Altaher, Mahir, additional, Altamimi, Turki, additional, Altamirano, Jose, additional, Alvares-da-Silva, Mario R., additional, Aly, Elsragy Adel M., additional, Alzahaby, Amgad, additional, Alzamzamy, Ahmed, additional, Amano, Keisuke, additional, Amer, Maysa A., additional, Amin, Mona A., additional, Amin, Sayed A., additional, Amir, Ashraf A., additional, Ampuero, Javier, additional, Anas, Noha, additional, Andreone, Pietro, additional, Andriamandimby, Soa Fy, additional, Anees, Mahmoud, additional, Angela, Peltec, additional, Antonios, Manal, additional, Arafat, Wael, additional, Araya, Jose Moreno, additional, Armendariz-Borunda, Juan, additional, Armstrong, Matthew J., additional, Ashktorab, Hassan, additional, Aspichueta, Patricia, additional, Assal, Fathia, additional, Atef, Mira, additional, Attia, Dina, additional, Atwa, Hoda, additional, Awad, Reham, additional, Awad, Mohyeldeen Abd Elaziz, additional, Awny, Sally, additional, Awolowo, Obafemi, additional, Awuku, Yaw Asante, additional, Ayada, Ibrahim, additional, Aye, Than Than, additional, Ayman, Sherif, additional, Ayman, Hedy, additional, Ayoub, Hesham, additional, Azmy, Hosny M., additional, Babaran, Romiro P., additional, Badreldin, Omneya, additional, Badry, Ahmed, additional, Bahçecioğlu, İbrahim Halil, additional, Bahour, Amira, additional, Bai, Jiajia, additional, Balaban, Yasemin, additional, Balasubramanyam, Muthuswamy, additional, Bamakhrama, Khaled, additional, Banales, Jesus M, additional, Bangaru, Babu, additional, Bao, Jianfeng, additional, Barahona, Jorge Suazo, additional, Barakat, Salma, additional, Barbalho, Sandra Maria, additional, Barbra, Bikwa, additional, Barranco, Beatriz, additional, Barrera, Francisco, additional, Baumann, Ulrich, additional, Bazeed, Shamardan, additional, Bech, Eva, additional, Benayad, Aourarh, additional, Benesic, Andreas, additional, Bernstein, David, additional, Bessone, Fernando, additional, Birney, Susie, additional, Bisseye, Cyrille, additional, Blake, Martin, additional, Bobat, Bilal, additional, Bonfrate, Leonilde, additional, Bordin, Dmitry S, additional, Bosques-Padilla, Francisco, additional, Boursier, Jerome, additional, Boushab, Boushab Mohamed, additional, Bowen, David, additional, Bravo, Patricia Medina, additional, Brennan, Paul N, additional, Bright, Bisi, additional, Broekaert, Ilse, additional, Buque, Xabier, additional, Burgos-Santamaría, Diego, additional, Burman, Julio, additional, Busetto, Luca, additional, Byrne, Chris D., additional, Cabral-Prodigalidad, Patricia Anne I., additional, Cabrera-Alvarez, Guillermo, additional, Cai, Wei, additional, Cainelli, Francesca, additional, Caliskan, Ali Riza, additional, Canbay, Ali, additional, Cano-Contreras, Ana, additional, Cao, Hai-Xia, additional, Cao, Zhujun, additional, Carrion, Andres, additional, Carubbi, Francesca, additional, Casanovas, Teresa, additional, Castellanos Fernández, Marlen Ivón, additional, Chai, Jin, additional, Chan, Siew Pheng, additional, Charatcharoenwitthaya, Phunchai, additional, Chavez-Tapia, Norberto, additional, Chayama, Kazuaki, additional, Chen, Jinjun, additional, Chen, Lin, additional, Chen, Zhong-Wei, additional, Chen, Huiting, additional, Chen, Sui-Dan, additional, Chen, Qiang, additional, Chen, Yaxi, additional, Chen, Gang, additional, Chen, En-Quang, additional, Chen, Fei, additional, Chen, Pei-Jer, additional, Cheng, Robert, additional, Cheng, Wendy, additional, Chieh, Jack Tan Wei, additional, Chokr, Imad, additional, Cholongitas, Evangelos, additional, Choudhury, Ashok, additional, Chowdhury, Abhijit, additional, Chukwudike, Evaristus Sunday, additional, Ciardullo, Stefano, additional, Clayton, Michelle, additional, Clement, Karine, additional, Cloa, Marie Michelle, additional, Coccia, Cecilia, additional, Collazos, Cristina, additional, Colombo, Massimo, additional, Cosar, Arif Mansur, additional, Cotrim, Helma Pinchemel, additional, Couillerot, Joris, additional, Coulibaly, Alioune, additional, Crespo, Gonzalo, additional, Crespo, Javier, additional, Cruells, Maria, additional, Cua, Ian Homer Y., additional, Dabbous, Hesham K., additional, Dalekos, George N, additional, D'Alia, Patricia, additional, Dan, Li, additional, Dao, Viet Hang, additional, Darwish, Mostafa, additional, Datz, Christian, additional, Davalos-Moscol, Milagros B, additional, Dawoud, Heba, additional, de Careaga, Blanca Olaechea, additional, de Knegt, Robert, additional, de Ledinghen, Victor, additional, de Silva, Janaka, additional, Debzi, Nabil, additional, Decraecker, Marie, additional, Del Pozo, Elvira, additional, Delgado, Teresa C, additional, Delgado-Blanco, Manuel, additional, Dembiński, Łukasz, additional, Depina, Adilson, additional, Derbala, Moutaz, additional, Desalegn, Hailemichael, additional, Desbois-Mouthon, Christèle, additional, Desoky, Mahmoud, additional, Dev, Anouk, additional, Di Ciaula, Agostino, additional, Diago, Moisés, additional, Diallo, Ibrahima, additional, Díaz, Luis Antonio, additional, Dirchwolf, Melisa, additional, Dongiovanni, Paola, additional, Dorofeyev, Andrriy, additional, Dou, Xiaoguang, additional, Douglas, Mark W., additional, Doulberis, Michael, additional, Dovia, Cecil K., additional, Doyle, Adam, additional, Dragojević, Ivana, additional, Drenth, Joost PH, additional, Duan, Xuefei, additional, Dulskas, Audrius, additional, Dumitrascu, Dan L, additional, Duncan, Oliver, additional, Dusabejambo, Vincent, additional, Dwawhi, Rev. Shem N.A., additional, Eiketsu, Sho, additional, El Amrousy, Doaa, additional, El Deeb, Ahmed, additional, El Deriny, Ghada, additional, El Din, Hesham Salah, additional, El Kamshishy, Salwa, additional, El Kassas, Mohamed, additional, El Raziky, Maissa, additional, Elagamy, Osama A, additional, Elakel, Wafaa, additional, Elalfy, Dina, additional, Elaraby, Hanaa, additional, ElAwady, Heba, additional, Elbadawy, Reda, additional, Eldash, Hanaa Hassan, additional, Eldefrawy, Manal S., additional, Elecharri, Carol Lezama, additional, Elfaramawy, Amel, additional, Elfatih, Mohammed, additional, Elfiky, Mahmoud, additional, Elgamsy, Mohamed, additional, Elgendy, Mohamed, additional, El-Guindi, Mohamed A., additional, Elhussieny, Nagi, additional, Eliwa, Ahmed Maher, additional, Elkabbany, Zeineb, additional, El-Khayat, Hesham, additional, El-Koofy, Nehal M., additional, Elmetwalli, Alaa, additional, Elrabat, Amr, additional, El-Raey, Fathiya, additional, Elrashdy, Fatma, additional, Elsahhar, Medhat, additional, Elsaid, Esraa M., additional, Elsayed, Shimaa, additional, Elsayed, Hany, additional, Elsayed, Aly, additional, Elsayed, Amr M., additional, Elsayed, Hamdy, additional, El-Serafy, Magdy, additional, Elsharkawy, Ahmed M., additional, Elsheemy, Reem Yehia, additional, Elshemy, Eman Elsayed, additional, Elsherbini, Sara, additional, Eltoukhy, Naglaa, additional, Elwakil, Reda, additional, Emad, Ola, additional, Emad, Shaimaa, additional, Embabi, Mohamed, additional, Ergenç, Ilkay, additional, Ermolova, Tatiana, additional, Esmat, Gamal, additional, Esmat, Doaa M., additional, Estupiñan, Enrique Carrera, additional, Ettair, Said, additional, Eugen, Tcaciuc, additional, Ezz-Eldin, Mohammed, additional, Falcón, Lidia Patricia Valdivieso, additional, Fan, Yu-Chen, additional, Fandari, Samah, additional, Farag, Mahmoud, additional, Farahat, Taghreed Mohamed, additional, Fares, Eman M., additional, Fares, Michael, additional, Fassio, Eduardo, additional, Fathy, Hayam, additional, Fathy, Dina, additional, Fathy, Wael, additional, Fayed, Soheir, additional, Feng, Dan, additional, Feng, Gong, additional, Fernández-Bermejo, Miguel, additional, Ferreira, Cristina Targa, additional, Ferrer, Javier Díaz, additional, Forbes, Alastair, additional, Fouad, Rabab, additional, Fouad, Hanan M., additional, Frisch, Tove, additional, Fujii, Hideki, additional, Fukunaga, Shuhei, additional, Fukunishi, Shinya, additional, Fulya, Hacer, additional, Furuhashi, Masato, additional, Gaber, Yasmine, additional, Galang, Augusto Jose G., additional, Gallardo, Jacqueline Cordova, additional, Galloso, Rocío, additional, Gamal, Mahmoud, additional, Gamal, Reham, additional, Gamal, Hadeel, additional, Gan, Jian, additional, Ganbold, Anar, additional, Gao, Xin, additional, Garas, George, additional, Garba, Tony, additional, García-Cortes, Miren, additional, García-Monzón, Carmelo, additional, García-Samaniego, Javier, additional, Gastaldelli, Amalia, additional, Gatica, Manuel, additional, Gatley, Elizabeth, additional, Gegeshidze, Tamar, additional, Geng, Bin, additional, Ghazinyan, Hasmik, additional, Ghoneem, Salma, additional, Giacomelli, Luca, additional, Giannelli, Gianluigi, additional, Giannini, Edoardo G., additional, Giefer, Matthew, additional, Ginès, Pere, additional, Girala, Marcos, additional, Giraudi, Pablo J, additional, Goh, George Boon-Bee, additional, Gomaa, Ahmed Ali, additional, Gong, Benbingdi, additional, Gonzales, Dina Hilda C., additional, Gonzalez, Humberto C., additional, Gonzalez-Huezo, Maria Saraí, additional, Graupera, Isabel, additional, Grgurevic, Ivica, additional, Grønbæk, Henning, additional, Gu, Xuelian, additional, Guan, Lin, additional, Gueye, Ibrahima, additional, Guingané, Alice Nanelin, additional, Gul, Ozen Oz, additional, Gul, Cuma Bulent, additional, Guo, Qing, additional, Gupta, Pramendra Prasad, additional, Gurakar, Ahmet, additional, Gutierrez, Juan Carlos Restrepo, additional, Habib, Ghada, additional, Hafez, Azaa, additional, Hagman, Emilia, additional, Halawa, Eman, additional, Hamdy, Osama, additional, Hamed, Abd Elkhalek, additional, Hamed, Dina H., additional, Hamid, Saeed, additional, Hamoudi, Waseem, additional, Han, Yu, additional, Haridy, James, additional, Haridy, Hanan, additional, Harris, David C H Harris, additional, Hart, Michael, additional, Hasan, Fuad, additional, Hashim, Almoutaz, additional, Hassan, Israa, additional, Hassan, Ayman, additional, Hassan, Essam Ali, additional, Hassan, Adel Ahmed, additional, Hassan, Magda Shehata, additional, Hassanin, Fetouh, additional, Hassnine, Alshymaa, additional, Haukeland, John Willy, additional, Hawal, Amr Ismael M., additional, He, Jinfan, additional, He, Qiong, additional, He, Yong, additional, He, Fang-Ping, additional, Hegazy, Mona, additional, Hegazy, Adham, additional, Henegil, Osama, additional, Hernández, Nelia, additional, Hernández-Guerra, Manuel, additional, Higuera-de-la-Tijera, Fatima, additional, Hindy, Ibrahim, additional, Hirota, Keisuke, additional, Ho, Lee Chi, additional, Hodge, Alexander, additional, Hosny, Mohamed, additional, Hou, Xin, additional, Huang, Jiao-Feng, additional, Huang, Yan, additional, Huang, Zhifeng, additional, Huang, Yuan, additional, Huang, Ang, additional, Huang, Xiao-Ping, additional, Hui-ping, Sheng, additional, Hunyady, Bela, additional, Hussein, Mennatallah A., additional, Hussein, Osama, additional, Hussien, Shahinaz Mahmoud, additional, Ibáñez-Samaniego, Luis, additional, Ibdah, Jamal, additional, Ibrahim, Luqman, additional, Ibrahim, Miada, additional, Ibrahim, Ibrahim, additional, Icaza-Chávez, Maria E., additional, Idelbi, Sahar, additional, Idilman, Ramazan Idilman, additional, Ikeda, Mayumi, additional, Indolfi, Giuseppe, additional, Invernizzi, Federica, additional, Irshad, Iram, additional, Isa, Hasan Mohamed Ali, additional, Iskandar, Natacha Jreige, additional, Ismaiel, Abdulrahman, additional, Ismail, Mariam, additional, Ismail, Zulkifli, additional, Ismail, Faisal, additional, Iwamoto, Hideki, additional, Jack, Kathryn, additional, Jacob, Rachael, additional, Jafarov, Fuad, additional, Jafri, Wasim, additional, Jahshan, Helen, additional, Jalal, Prasun K, additional, Jancoriene, Ligita, additional, Janicko, Martin, additional, Jayasena, Hiruni, additional, Jefferies, Meryem, additional, Jha, Vivekanand, additional, Ji, Fanpu, additional, Ji, Yaqiu, additional, Jia, Jidong, additional, Jiang, Changtao, additional, Jiang, Ni, additional, Jiang, Zong-zhe, additional, Jin, Xing, additional, Jin, Yi, additional, Jing, Xu, additional, Jingyu, Qian, additional, Jinjolava, Maia, additional, Jong, FX Himawan Haryanto, additional, Jucov, Alina, additional, Julius, Ibecheole, additional, Kaddah, Mona, additional, Kamada, Yoshihiro, additional, kamal, Abobakr, additional, Kamal, Enas Mohamed, additional, Kamel, Ashraf Sayed, additional, Kao, Jia-Horng, additional, Karin, Maja, additional, Karlas, Thomas, additional, Kashwaa, Mohammad, additional, Katsidzira, Leolin, additional, Kaya, Eda, additional, Kayasseh, M.Azzam, additional, Keenan, Bernadette, additional, Keklikkiran, Caglayan, additional, Keml, William, additional, Khalaf, Deia K., additional, Khalefa, Rofida, additional, Khamis, Sherin, additional, Khater, Doaa, additional, khattab, Hamed, additional, Khavkin, Anatoly, additional, Khlynova, Olga, additional, Khmis, Nabil, additional, Kobyliak, Nazarii, additional, Koffas, Apostolos, additional, Koike, Kazuhiko, additional, Kok, Kenneth Y.Y., additional, Koller, Tomas, additional, Komas, Narcisse Patrice, additional, Korochanskaya, Nataliya V., additional, Koulla, Yannoula, additional, Koya, Shunji, additional, Kraft, Colleen, additional, Kraja, Bledar, additional, Krawczyk, Marcin, additional, Kuchay, Mohammad Shafi, additional, Kulkarni, Anand V, additional, Kumar, Ashish, additional, Kumar, Manoj, additional, Lakoh, Sulaiman, additional, Lam, Philip, additional, Lan, Ling, additional, Lange, Naomi F., additional, Lankarani, Kamran Bagheri, additional, Lanthier, Nicolas, additional, Lapshyna, Kateryna, additional, Lashen, Sameh A., additional, Laure, Konang Nguieguia Justine, additional, Lazebnik, Leonid, additional, Lebrec, Didier, additional, Lee, Samuel S., additional, Lee, Way Seah, additional, Lee, Yeong Yeh, additional, Leeming, Diana Julie, additional, Leite, Nathalie Carvalho, additional, Leon, Roberto, additional, Lesmana, Cosmas Rinaldi Adithya, additional, Li, Junfeng, additional, Li, Qiong, additional, Li, Jun, additional, Li, Yang-Yang, additional, Li, Yufang, additional, Li, Lei, additional, Li, Min, additional, li, Yiling, additional, Liang, Huiqing, additional, Lijuan, Tang, additional, Lim, Seng Gee, additional, Lim, Lee-Ling, additional, Lin, Shumei, additional, Lin, Han-Chieh, additional, Lin, Rita, additional, Lithy, Rania, additional, Liu, Yaru, additional, Liu, Yuanyuan, additional, Liu, Xin, additional, Liu, Wen-Yue, additional, Liu, Shourong, additional, Liu, Ken, additional, Liu, Tian, additional, Lonardo, Amedeo, additional, López, Mariana Bravo, additional, López-Benages, Eva, additional, Lopez-Jaramillo, Patricio, additional, Lu, Huimin, additional, Lu, Lun Gen, additional, Lu, Yan, additional, Lubel, John, additional, Lui, Rashid, additional, Lupasco, Iulianna, additional, Luzina, Elena, additional, Lv, Xiao-Hui, additional, Lynch, Kate, additional, Ma, Hong-Lei, additional, Machado, Mariana Verdelho, additional, Maduka, Nonso, additional, Madzharova, Katerina, additional, Magdaong, Russellini, additional, Mahadeva, Sanjiv, additional, Mahfouz, Amel, additional, Mahmood, Nik Ritza Kosai Nik, additional, Mahmoud, Eman, additional, Mahrous, Mohamed, additional, Maiwall, Rakhi, additional, Majeed, Ammar, additional, Majumdar, Avik, additional, Mak, Loey, additional, Maklouf, Madiha M, additional, Malekzadeh, Reza, additional, Mandato, Claudia, additional, Mangia, Alessandra, additional, Mann, Jake, additional, Mansour, Hala Hussien, additional, Mansouri, Abdellah, additional, Mantovani, Alessandro, additional, Mao, Jun qian, additional, Maramag, Flor, additional, Marchesini, Giulio, additional, Marcus, Claude, additional, Marinho, Rui António Rocha Tato, additional, Martinez-Chantar, Maria L, additional, Martins, Antonieta A. Soares, additional, Marwan, Rana, additional, Mason, Karen Frances, additional, Masoud, Ghadeer, additional, Massoud, Mohamed Naguib, additional, Matamoros, Maria Amalia, additional, Mateos, Rosa Martín, additional, Mawed, Asmaa, additional, Mbanya, Jean Claude, additional, Mbendi, Charles, additional, McColaugh, Lone, additional, McLeod, Duncan, additional, Medina, Juan Francisco Rivera, additional, Megahed, Ahmed, additional, Mehrez, Mai, additional, Memon, Iqbal, additional, Merat, Shahin, additional, Mercado, Randy, additional, Mesbah, Ahmed, additional, Meskini, Taoufik, additional, Metwally, Mayada, additional, Metwaly, Rasha, additional, Miao, Lei, additional, Micah, Eileen, additional, Miele, Luca, additional, Milivojevic, Vladimir, additional, Milovanovic, Tamara, additional, Mina, Yvonne L., additional, Mishkovik, Milan, additional, Mishriki, Amal, additional, Mitchell, Tim, additional, Mohamed, Alshaimaa, additional, Mohamed, Mona, additional, Mohamed, Sofain, additional, Mohammed, Shady, additional, Mohammed, Ahmed, additional, Mohan, Viswanathan, additional, Mohie, Sara, additional, Mokhtar, Aalaa, additional, Moniem, Reham, additional, Montilla, Mabel Segura, additional, Morales, Jose Antonio Orozco, additional, Morata, María María Sánchez, additional, Moreno-Planas, Jose Maria, additional, Morise, Silvia, additional, Mosaad, Sherif, additional, Moselhy, Mohamed, additional, Mostafa, Alaa Mohamed, additional, Mostafa, Ebraheem, additional, Mouane, Nezha, additional, Mousa, Nasser, additional, Moustafa, Hamdy Mahfouz, additional, Msherif, Abeer, additional, Muller, Kate, additional, Munoz, Christopher, additional, Muñoz-Urribarri, Ana Beatriz, additional, Murillo, Omar Alfaro, additional, Mustapha, Feisul Idzwan, additional, Muzurović, Emir, additional, Nabil, Yehia, additional, Nafady, Shaymaa, additional, Nagamatsu, Ayu, additional, Nakajima, Atsushi, additional, Nakano, Dan, additional, Nan, Yuemin, additional, Nascimbeni, Fabio, additional, Naseef, Mirella S., additional, Nashat, Nagwa, additional, Natalia, Taran, additional, Negro, Francesco, additional, Nersesov, Alexander V., additional, Neuman, Manuela, additional, Ng'wanasayi, Masolwa, additional, Ni, Yan, additional, Nicoll, Amanda, additional, Niizeki, Takashi, additional, Nikolova, Dafina, additional, Ningning, Wang, additional, Niriella, Madunil, additional, Nogoibaeva, K.A, additional, Nordien, Rozeena, additional, O Sullivan, Catherine, additional, O'Beirne, James, additional, Obekpa, Solomon, additional, Ocama, Ponsiano, additional, Ochwoto, Missiani, additional, Ogolodom, Michael Promise, additional, Ojo, Olusegun, additional, Okrostsvaridze, Nana, additional, Oliveira, Claudia P., additional, Omaña, Raul Contreras, additional, Omar, Omneya M., additional, Omar, Hanaa, additional, Omar, Mabroka, additional, Omran, Salma, additional, Omran, Reham, additional, Osman, Marian Muse, additional, Owise, Nevin, additional, Owusu-Ansah, Theobald, additional, Padilla- Machaca, P. Martín, additional, Palle, Sirish, additional, Pan, Ziyan, additional, Pan, Xiao-Yan, additional, Pan, Qiuwei, additional, Papaefthymiou, Apostolis, additional, Paquissi, Feliciano Chanana, additional, Par, Gabriella, additional, Parkash, Arit, additional, Payawal, Diana, additional, Peltekian, Kevork M., additional, Peng, Xuebin, additional, Peng, Liang, additional, Peng, Ying, additional, Pengoria, Rahul, additional, Perez, Martina, additional, Pérez, José Luis, additional, Pérez, Norma Marlene, additional, Persico, Marcello, additional, Pessoa, Mário Guimarães, additional, Petta, Salvatore, additional, Philip, Mathew, additional, Plaz Torres, Maria Corina, additional, Polavarapu, Naveen, additional, Poniachik, Jaime, additional, Portincasa, Piero, additional, Pu, Chunwen, additional, Pürnak, Tuğrul, additional, Purwanto, Edhie, additional, Qi, Xiaolong, additional, Qi, Xingshun, additional, Qian, Zibing, additional, Qiang, Zhao, additional, Qiao, Zengpei, additional, Qiao, Liang, additional, Queiroz, Alberto, additional, Rabiee, Atoosa, additional, Radwan, Manal, additional, Rahetilahy, Alain Marcel, additional, Ramadan, Yasmin, additional, Ramadan, Dina, additional, Ramli, Anis Safura, additional, Ramm, Grant A., additional, Ran, Ao, additional, Rankovic, Ivan, additional, RAO, Huiying, additional, Raouf, Sara, additional, Ray, Sayantan, additional, Reau, Nancy, additional, Refaat, Ahmed, additional, Reiberger, Thomas, additional, Remes-Troche, Jose M, additional, Reyes, Eira Cerda, additional, Richardson, Ben, additional, Ridruejo, Ezequiel, additional, Riestra Jimenez, Sergio, additional, Rizk, Ibrahim, additional, Roberts, Stuart, additional, Roblero, Juan Pablo, additional, Robles, Jorge Alberto Prado, additional, Rockey, Don, additional, Rodríguez, Manuel, additional, Rodríguez Hernández, Heriberto, additional, Román, Eva, additional, Romeiro, Fernando Gomes, additional, Romeo, Stefano, additional, Rosales-Zabal, Jose Miguel, additional, Roshdi, Georgina R., additional, Rosso, Natalia, additional, Ruf, Andres, additional, Ruiz, Patricia Cordero, additional, Runes, Nelia R., additional, Ruzzenente, Andrea, additional, Ryan, Marno, additional, Saad, Ahmed, additional, Sabbagh, Eman BE, additional, Sabbah, Meriam, additional, Saber, Shimaa, additional, Sabrey, Reham, additional, Sabry, Ramy, additional, Saeed, Maysaa Abdallah, additional, Said, Dina, additional, Said, Ebada M, additional, Sakr, Mohammad Amin, additional, Salah, Yara, additional, Salama, Rabab Maamoun, additional, Salama, Asmaa, additional, Saleh, Hussein, additional, Saleh, Ahmed, additional, Salem, Ahmed, additional, Salem, Ahmed Thabet, additional, Salifou, Alkassoum, additional, Salih, Aso Faeq, additional, Salman, Abdallah, additional, Samouda, Hanen, additional, Sanai, Faisal, additional, Sánchez-Ávila, Juan Francisco, additional, Sanker, Lakshumanan, additional, Sano, Tomoya, additional, Sanz, Miquel, additional, Saparbu, Tobokalova, additional, Sawhney, Rohit, additional, Sayed, Fatma, additional, Sayed, Sayed A., additional, Sayed, Ashraf Othman, additional, Sayed, Manar, additional, Sebastiani, Giada, additional, Secadas, Laura, additional, Sediqi, Khawaja Qamaruddin, additional, Seif, Sameh, additional, Semida, Nady, additional, Şenateş, Ebubekir, additional, Serban, Elena Daniela, additional, Serfaty, Lawrence, additional, Seto, Wai-Kay, additional, Sghaier, Ikram, additional, Sha, Min, additional, Shabaan, Hamada M., additional, Shalaby, Lobna, additional, Shaltout, Inass, additional, Sharara, Ala I., additional, Sharma, Vishal, additional, Shawa, Isaac Thom, additional, Shawkat, Ahmed, additional, Shawky, Nehal, additional, Shehata, Osama, additional, Sheils, Sinead, additional, Shewaye, Abate Bane, additional, Shi, Guojun, additional, Shi, Junping, additional, Shimose, Shigeo, additional, Shirono, Tomotake, additional, Shou, Lan, additional, Shrestha, Ananta, additional, Shui, Guanghou, additional, Sievert, William, additional, Sigurdardottir, Solveig, additional, Sira, Mostafa Mohamed, additional, Siradj, Riyadh, additional, Sison, Cecilia, additional, Smyth, Linda, additional, Soliman, Reham, additional, Sollano, Jose D, additional, Sombie, Roger, additional, Sonderup, Mark, additional, Sood, Siddharth, additional, Soriano, German, additional, Stedman, Catherine A M, additional, Stefanyuk, Oksana, additional, Štimac, Davor, additional, Strasser, Simone, additional, Strnad, Pavel, additional, Stuart, Katherine, additional, Su, Wen, additional, Su, Minghua, additional, Sumida, Yoshio, additional, Sumie, Shuji, additional, Sun, Dan-Qin, additional, Sun, Jing, additional, Suzuki, Hiroyuki, additional, Svegliati-Baroni, Gianluca, additional, Swar, Mohamed Osman, additional, TAHARBOUCHT, S., additional, Taher, Zenab, additional, Takamura, Saori, additional, Tan, Lin, additional, Tan, Soek-Siam, additional, Tanwandee, Tawesak, additional, Tarek, Sara, additional, Tatiana, Ghelimici, additional, Tavaglione, Federica, additional, Tecson, Gina Y., additional, Tee, Hoi-Poh, additional, Teschke, Rolf, additional, Tharwat, Mostafa, additional, Thong, Vo Duy, additional, Thursz, Mark, additional, Tine, Tulari, additional, Tiribelli, Claudio, additional, Tolmane, Ieva, additional, Tong, Jing, additional, Tongo, Marco, additional, Torkie, Mamdouh, additional, Torre, Aldo, additional, Torres, Esther A, additional, Trajkovska, Meri, additional, Treeprasertsuk, Sombat, additional, Tsutsumi, Tsubasa, additional, Tu, Thomas, additional, Tur, Josep A., additional, Turan, Dilara, additional, Turcan, Svetlana, additional, Turkina, Svetlana, additional, Tutar, Engin, additional, Tzeuton, Christian, additional, Ugiagbe, Rose, additional, Uygun, Ahmet, additional, Vacca, Michele, additional, Vajro, Pietro, additional, Van der Poorten, David, additional, Van Kleef, Laurens A., additional, Vashakidze, Eliza, additional, Velazquez, Carlos Moctezuma, additional, Velazquez, Mirtha Infante, additional, Vento, Sandro, additional, Verhoeven, Veronique, additional, Vespasiani-Gentilucci, Umberto, additional, Vethakkan, Shireene Ratna, additional, Vilaseca, Josep, additional, Vítek, Libor, additional, Volkanovska, Ance, additional, Wallace, Michael, additional, Wan, Wang, additional, Wang, Yan, additional, Wang, Ying, additional, Wang, Xiaolin, additional, Wang, Xuemei, additional, Wang, Chengyan, additional, Wang, Chunjiong, additional, Wang, Mingjie, additional, Wangchuk, Pelden, additional, Weltman, Martin, additional, White, MaryFrances, additional, Wiegand, Johannes, additional, Wifi, Mohamed-Naguib, additional, Wigg, Alan, additional, Wilhelmi, Markus, additional, William, Remon, additional, Wittenburg, Henning, additional, Wu, Shengjie, additional, Wubeneh, Abdu Mohammed, additional, Xia, Hongping, additional, Xiao, Jian, additional, Xiao, Xiao, additional, Xiaofeng, Wang, additional, Xiong, Wanyuan, additional, Xu, Liang, additional, Xu, Jie, additional, Xu, Weiguo, additional, Xu, Jing-Hang, additional, Xu, Keshu, additional, Xu, Yumin, additional, Xu, Shi-Hao, additional, Xu, Meng, additional, Xu, Aimin, additional, Xu, Chengfu, additional, Yan, Hongmei, additional, Yang, Jingyi, additional, Yang, Rui-Xu, additional, Yang, Yating, additional, Yang, Qinhe, additional, Yang, Naibin, additional, Yao, Jia, additional, Yara, Justine, additional, Yaraş, Serkan, additional, Yılmaz, Nimet, additional, Younes, Ramy, additional, younes, Huda, additional, Young, Sona, additional, Youssef, Farah, additional, Yu, Yanyan, additional, Yu, Ming-Lung, additional, Yuan, Jing, additional, Yue, Zhang, additional, Yuen, Man-Fung, additional, Yun, Wang, additional, Yurukova, Nonka, additional, Zakaria, Serag, additional, Zaky, Samy, additional, Zaldastanishvili, Maia, additional, Zapata, Rodrigo, additional, Zare, Nazanin, additional, Zerem, Enver, additional, Zeriban, Nema, additional, Zeshuai, Xu, additional, Zhang, Huijie, additional, Zhang, Xuemei, additional, Zhang, Yupei, additional, Zhang, Wen-Hua, additional, Zhang, Xuchen, additional, Zhang, Yon-ping, additional, Zhang, Yuexin, additional, Zhang, Zhan-qing, additional, Zhao, Jingmin, additional, Zhao, Rong-Rong, additional, Zhao, Hongwei, additional, Zheng, Chao, additional, Zheng, Yijie, additional, Zheng, Ruidan, additional, Zheng, Tian-Lei, additional, Zheng, Kenneth, additional, Zhou, Xi Qiao, additional, Zhou, Yongjian, additional, Zhou, Yu-Jie, additional, Zhou, Hong, additional, Zhou, Ling, additional, Zhou, Yongning, additional, Zhu, Long dong, additional, Zhu, Yong Fen, additional, Zhu, Yueyong, additional, Zhu, Pei-Wu, additional, Ziada, Ebtesam, additional, Ziring, David, additional, Ziyi, Li, additional, Zou, Shanshan, additional, Zou, Zhengsheng, additional, Zou, Huaibin, additional, and Zuart Ruiz, Roberto, additional
- Published
- 2022
- Full Text
- View/download PDF
46. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance
- Author
-
Johnson, Katherine, Leary, Peter J., Govaere, Olivier, Barter, Matthew J., Charlton, Sarah H., Cockell, Simon J., Tiniakos, Dina, Zatorska, Michalina, Bedossa, Pierre, Brosnan, M. Julia, Cobbold, Jeremy F., Ekstedt, Mattias, Aithal, Guruprasad P., Boursier, Jerome, Ratziu, Vlad, Bugianesi, Elisabetta, Anstee, Quentin M., Daly, Ann K., Clark, James, Cockell, Simon, Cordell, Heather J., Darlay, Rebecca, Day, Christopher P., Hardy, Tim, Liu, Yang-Lin, Oakley, Fiona, Palmer, Jeremy, Queen, Rachel, Wonders, Kristy, Bossuyt, Patrick M., Holleboom, Adriaan G., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Clement, Karine, Pais, Raluca, Schuppan, Detlef, Allison, Michael, Cuenca, Sergio Rodriguez, Pellegrinelli, Vanessa, Vacca, Michele, Vidal-Puig, Antonio, McGlinchey, Aidan, Sen, Partho, Mato, Jose, Dufour, Jean-Francois, Harrison, Stephen, Neubauer, Stefan, Pavlides, Michael, Mozes, Ferenc, Akhtar, Salma, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Erpicum, Charlotte, Romero-Gomez, Manuel, Karsdal, Morten, Leeming, Diana, Fisker, Mette Juul, Erhardtsen, Elisabeth, Rasmussen, Daniel, Qvist, Per, Sinisi, Antonia, Sandt, Estelle, Tonini, Maria Manuela, Parola, Maurizio, Rosso, Chiara, Marra, Fabio, Gastaldelli, Amalia, Francque, Sven, Kechagias, Stergios, Porthan, Kimmo, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Valenti, Luca, Petta, Salvatore, Miele, Luca, Geier, Andreas, Trautwein, Christian, Hockings, Paul, Newsome, Phil, Wenn, David, Chaumat, Pierre, Rosenquist, Christian, Trylesinski, Aldo, Ortiz, Pablo, Duffin, Kevin, Yunis, Carla, Miller, Melissa, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Alexander, Leigh, Ostroff, Rachel, Mikkelsen, Lars Friis, Brass, Clifford, Jennings, Lori, Balp, Maria-Magdalena, Martic, Miljen, Hanauer, Guido, Shankar, Sudha, Torstenson, Richard, Ehman, Richard, Kalutkiewicz, Michael, Pepin, Kay, Myers, Joel, Shevell, Diane, Ho, Gideon, Landgren, Henrik, Myers, Rob, Doward, Lynda, Whalley, Diane, and Twiss, James
- Subjects
Hepatology ,Gastroenterology ,Internal Medicine ,Immunology and Allergy ,digestive system diseases - Abstract
Background & Aims: Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods: We profiled 2,083 serum miRNAs in a discovery cohort (183 cases with NAFLD representing the complete NAFLD spectrum and 10 population controls). miRNA libraries generated by HTG EdgeSeq were sequenced by Illumina NextSeq. Selected serum miRNAs were profiled in 372 additional cases with NAFLD and 15 population controls by quantitative reverse transcriptase PCR. Results: Levels of 275 miRNAs differed between cases and population controls. Fewer differences were seen within individual NAFLD stages, but miR-193a-5p consistently showed increased levels in all comparisons. Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2–4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5–8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2–4 compared with lower SAF activity. The significant findings for miR-193a-5p were replicated in the additional cohort with NAFLD. Studies in Hep G2 cells showed that following palmitic acid treatment, miR-193a-5p expression decreased significantly. Gene targets for miR-193a-5p were investigated in liver RNAseq data for a case subgroup (n = 80); liver GPX8 levels correlated positively with serum miR-193a-5p. Conclusions: Serum miR-193a-5p levels correlate strongly with NAFLD activity grade and fibrosis stage. MiR-193a-5p may have a role in the hepatic response to oxidative stress and is a potential clinically tractable circulating biomarker for progressive NAFLD. Lay summary: MicroRNAs (miRNAs) are small pieces of nucleic acid that may turn expression of genes on or off. These molecules can be detected in the blood circulation, and their levels in blood may change in liver disease including non-alcoholic fatty liver disease (NAFLD). To see if we could detect specific miRNA associated with advanced stages of NAFLD, we carried out miRNA sequencing in a group of 183 patients with NAFLD of varying severity together with 10 population controls. We found that a number of miRNAs showed changes, mainly increases, in serum levels but that 1 particular miRNA miR-193a-5p consistently increased. We confirmed this increase in a second group of cases with NAFLD. Measuring this miRNA in a blood sample may be a useful way to determine whether a patient has advanced NAFLD without an invasive liver biopsy.
- Published
- 2022
47. Additional file 1 of Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
- Author
-
Seyres, Denis, Cabassi, Alessandra, Lambourne, John J., Burden, Frances, Farrow, Samantha, McKinney, Harriet, Batista, Joana, Kempster, Carly, Pietzner, Maik, Slingsby, Oliver, Cao, Thong Huy, Quinn, Paulene A., Stefanucci, Luca, Sims, Matthew C., Rehnstrom, Karola, Adams, Claire L., Frary, Amy, Erg��ener, Bekir, Kreuzhuber, Roman, Mocciaro, Gabriele, D���Amore, Simona, Koulman, Albert, Grassi, Luigi, Griffin, Julian L., Ng, Leong Loke, Park, Adrian, Savage, David B., Langenberg, Claudia, Bock, Christoph, Downes, Kate, Wareham, Nicholas J., Allison, Michael, Vacca, Michele, Kirk, Paul D. W., and Frontini, Mattia
- Abstract
Additional file 1: Fig. S1. Overview of experimental design. A. Parameters used to define lean individuals amongst blood donors and controls. B. Overview of the analysis set-up to determine the effects of bariatric surgery. To minimise batch effects, 20 additional blood donors ("Controls") were recruited and were not previously present in the original BluePrint cohort. We applied a set of filters (METHODS) to identify low risk individuals within the 20 Controls, designed hereafter as "Lean-Control". C. Overview of multi-omics integration. In brief, data from 202 individuals identified as blood donors ("BD") in the present study, were collected from BluePrint consortium. It included, for monocytes and neutrophils, H3K27ac ChIP-seq, RNA-seq and 450K methylation arrays. Additionally, we obtained anthropometric measurements (BW, BMI) and generated plasma biochemistry assays, plasma metabolomics, plasma lipidomics on samples collected from the same individuals at the same time. Case groups were composed of obese individuals referred for bariatric surgery and lipodystrophy patients. Data for these groups were generated in this study. We applied a set of filters (METHODS) to identify low risk individuals within the 202 blood donors, designed hereafter as "Lean-BD".
- Published
- 2022
- Full Text
- View/download PDF
48. Additional file 6 of Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
- Author
-
Seyres, Denis, Cabassi, Alessandra, Lambourne, John J., Burden, Frances, Farrow, Samantha, McKinney, Harriet, Batista, Joana, Kempster, Carly, Pietzner, Maik, Slingsby, Oliver, Cao, Thong Huy, Quinn, Paulene A., Stefanucci, Luca, Sims, Matthew C., Rehnstrom, Karola, Adams, Claire L., Frary, Amy, Erg��ener, Bekir, Kreuzhuber, Roman, Mocciaro, Gabriele, D���Amore, Simona, Koulman, Albert, Grassi, Luigi, Griffin, Julian L., Ng, Leong Loke, Park, Adrian, Savage, David B., Langenberg, Claudia, Bock, Christoph, Downes, Kate, Wareham, Nicholas J., Allison, Michael, Vacca, Michele, Kirk, Paul D. W., and Frontini, Mattia
- Abstract
Additional file 6. Extended methods describing biochemical profiling.
- Published
- 2022
- Full Text
- View/download PDF
49. Additional file 4 of Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
- Author
-
Seyres, Denis, Cabassi, Alessandra, Lambourne, John J., Burden, Frances, Farrow, Samantha, McKinney, Harriet, Batista, Joana, Kempster, Carly, Pietzner, Maik, Slingsby, Oliver, Cao, Thong Huy, Quinn, Paulene A., Stefanucci, Luca, Sims, Matthew C., Rehnstrom, Karola, Adams, Claire L., Frary, Amy, Erg��ener, Bekir, Kreuzhuber, Roman, Mocciaro, Gabriele, D���Amore, Simona, Koulman, Albert, Grassi, Luigi, Griffin, Julian L., Ng, Leong Loke, Park, Adrian, Savage, David B., Langenberg, Claudia, Bock, Christoph, Downes, Kate, Wareham, Nicholas J., Allison, Michael, Vacca, Michele, Kirk, Paul D. W., and Frontini, Mattia
- Abstract
Additional file 4: Fig. S4. Related to Figure 3���Multi-omic signatures of extreme phenotype groups and their use in prediction. A. Plots showing individuals ranked by their predicted probability of belonging to the obese group. As in Figure 3C, but for the Methylation (monocytes), RNA-Seq (monocytes), Metabolites, and ChIP-Seq (monocytes) data layers. B. Multi-omic model trained using lipodystrophy patients often predicts obese individuals to belong to the lipodystrophy group. As in Figure 3C (final plot), but training the multi-layer model using the Lipodystrophy and Lean-BD groups (rather than the Obese and Lean-BD groups). Using this model, Obese individuals were often predicted as belonging to the Lipodystrophy group.
- Published
- 2022
- Full Text
- View/download PDF
50. Additional file 5 of Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
- Author
-
Seyres, Denis, Cabassi, Alessandra, Lambourne, John J., Burden, Frances, Farrow, Samantha, McKinney, Harriet, Batista, Joana, Kempster, Carly, Pietzner, Maik, Slingsby, Oliver, Cao, Thong Huy, Quinn, Paulene A., Stefanucci, Luca, Sims, Matthew C., Rehnstrom, Karola, Adams, Claire L., Frary, Amy, Erg��ener, Bekir, Kreuzhuber, Roman, Mocciaro, Gabriele, D���Amore, Simona, Koulman, Albert, Grassi, Luigi, Griffin, Julian L., Ng, Leong Loke, Park, Adrian, Savage, David B., Langenberg, Claudia, Bock, Christoph, Downes, Kate, Wareham, Nicholas J., Allison, Michael, Vacca, Michele, Kirk, Paul D. W., and Frontini, Mattia
- Subjects
digestive system diseases ,health care economics and organizations - Abstract
Additional file 5: Fig. S5. Related to Figure 3���A common pattern of associations between the prioritised lipid species and known CMS risk factors. The pattern of association between the prioritised lipids and known CMS risk factors in the NASH cohort (NASH cohort; left) agrees with the results from the present study (BD cohort; right).
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.