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1,035 results on '"Vajpayee, Rasik B"'

1. Infectious corneal ulceration: a proposal for neglected tropical disease status

Author

Ung, Lawson, Acharya, Nisha R, Agarwal, Tushar, Alfonso, Eduardo C, Bagga, Bhupesh, Bispo, Paulo JM, Burton, Matthew J, Dart, John KG, Doan, Thuy, Fleiszig, Suzanne MJ, Garg, Prashant, Gilmore, Michael S, Gritz, David C, Hazlett, Linda D, Iovieno, Alfonso, Jhanji, Vishal, Kempen, John H, Lee, Cecilia S, Lietman, Thomas M, Margolis, Todd P, McLeod, Stephen D, Mehta, Jod S, Miller, Darlene, Pearlman, Eric, Prajna, Lalitha, Prajna, N Venkatesh, Seitzman, Gerami D, Shanbhag, Swapna S, Sharma, Namrata, Sharma, Savitri, Srinivasan, Muthiah, Stapleton, Fiona, Tan, Donald TH, Tandon, Radhika, Taylor, Hugh R, Tu, Elmer Y, Tuli, Sonal S, Vajpayee, Rasik B, Van Gelder, Russell N, Watson, Stephanie L, Zegans, Michael E, and Chodosh, James

Subjects
Anti-Bacterial Agents, Bacterial Infections, Corneal Ulcer, Developing Countries, Global Health, Health Promotion, Humans, Leprosy, Neglected Diseases, Onchocerciasis, Ocular, Trachoma, Medical and Health Sciences, Tropical Medicine
Published
2019

19. Post-penetrating keratoplasty astigmatism

Author

Deshmukh, Rashmi, primary, Nair, Sridevi, additional, Vaddavalli, Pravin K, additional, Agrawal, Tushar, additional, Rapuano, Christopher J, additional, Beltz, Jacqueline, additional, and Vajpayee, Rasik B., additional

Published
2022
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23. Management of corneal perforations in dry eye disease: Preferred practice pattern guidelines.

Author

Kate, Anahita, Deshmukh, Rashmi, Donthineni, Pragnya R., Sharma, Namrata, Vajpayee, Rasik B., and Basu, Sayan

Subjects
DRY eye syndromes, CORNEA injuries, EYE diseases, AMNION, TOPICAL drug administration, WOUND healing, EVIDENCE-based management
Abstract

Corneal perforations in eyes with dry eye disease (DED) are difficult to manage due to the interplay of several factors such as the unstable tear film, surface inflammation, and the underlying systemic disease affecting the wound healing process, and the eventual outcome. A careful preoperative examination is required to identify the underlying pathology, and status of ocular surface and adnexa, rule out microbial keratitis, and order appropriate systemic workup in addition to assessing the perforation itself. Several surgical options are available, which include tissue adhesives, multilayered amniotic membrane grafting (AMT), tenon patch graft (TPG), corneal patch graft (CPG), and penetrating keratoplasty (PK). The choice of procedure depends upon the size, location, and configuration of the perforation. In eyes with smaller perforations, tissue adhesives are effective treatment modalities, whereas AMT, TPG, and CPG are viable options in moderate‑sized perforations. AMT and TPG are also preferable in cases where the placement of a bandage contact lens may be a challenge. Large perforations require a PK, with additional procedures such as tarsorrhaphy to protect the eyes from the associated epithelial healing issues. Conjunctival flaps are considered in eyes with poor visual potential. The management of the acute condition is carried out in conjunction with measures to improve the tear volume bearing in mind the chances of delayed epithelialization and re‑perforation in these cases. Administration of topical and systemic immunosuppression, when indicated, helps improve the outcome. This review aims to facilitate clinicians in instituting a synchronized multifaceted therapy for the successful management of corneal perforations in the setting of DED. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Prognostic significance of matrix metalloproteinase 9 in COMET operated chronic ocular Stevens-Johnson syndrome.

Author

Venugopal, Renu, Sharma, Namrata, Sen, Seema, Mohanty, Sujata, Kashyap, Seema, Agarwal, Tushar, Kaur, Jasbir, and Vajpayee, Rasik B.

Abstract

Purpose Molecular pathogenesis underlying persistent ocular surface inflammation in chronic Stevens-Johnson syndrome (SJS) still remains largely unexplored. The present study investigates the expression of matrix metalloproteinase 2 (MMP2), MMP3, MMP9, MMP11 and TIMP1 (tissue inhibittor of matrix metalloproteinase 1) in pannus tissues of chronic ocular SJS undergoing cultivated oral mucosal epithelial transplantation (COMET) and their prognostic relevance. Methods In this prospective study, 45 eyes with chronic SJS underwent COMET for visual and anatomical rehabilitation. Preoperative and postoperative clinical parameters were documented. MMP2, MMP3, MMP9, MMP11 and TIMP1 expression were assessed using immunohistochemistry and quantitative real time PCR. Inflammadry MMP9 assay was performed at 1-year follow-up. Kaplan-Meier curves and Cox proportional hazard models were used to correlate protein expression with clinicopathological parameters and COMET graft survival outcomes. Results MMP9 and MMP11 positivity was seen in both pannus epithelia (48% and 55%, respectively) and in stromal layer (57% and 33%, respectively) while MMP2 and MMP3 showed only pannus epithelial positivity in 35% and 51% cases, respectively. High MMP9 stromal expression was significantly associated with preoperative corneal keratinisation (p=0.011), conjunctival hyperaemia (p=0.014), symblepharon (p=0.028). High MMP9 and MMP3 epithelial expression were found to be independent risk factors for poor best-corrected visual acuity (BCVA) outcomes post-COMET (p=0.022 and p=0.048). Multivariate analysis revealed MMP9 to be the best prognostic marker (p=0.050). Conclusion Our findings suggest that differential expression of MMPs and TIMP1 is seen in SJS in chronic stage. Emergence of MMP9 as a poor prognostic predictor of BCVA post COMET and postoperative MMP9 immunoassay positivity could be a useful tool in further studies to understand the unresolved ocular surface inflammation seen in SJS. [ABSTRACT FROM AUTHOR]

Published
2023
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45. A Comparison of Refractive Accuracy Between Conventional and Femtosecond Laser Cataract Surgery Techniques Using Modern IOL Formulas

Author

Connell,Benjamin J, Kane,Jack X, Vajpayee,Rasik B, Connell,Benjamin J, Kane,Jack X, and Vajpayee,Rasik B

Abstract

Benjamin J Connell,1,2 Jack X Kane,2 Rasik B Vajpayee2– 4 1Eye Surgery Associates, Melbourne, Victoria, Australia; 2Corneal Unit, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; 3Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia; 4Vision Eye Institute, Melbourne, Victoria, AustraliaCorrespondence: Benjamin J ConnellEye Surgery Associates, 2/232 Victoria Pde, East Melbourne, VIC, 3002, AustraliaTel +61 9416 0695Fax +61 9416 1816Email benconnell@outlook.com.auPurpose: To compare the refractive outcome prediction accuracy between conventional (CCS) and femtosecond laser assisted (FLACS) cataract surgery techniques using optimized lens constants for modern intraocular lens (IOL) formulas.Patients and Methods: Our retrospective, comparative, interventional case series, compared data from 196 eyes undergoing CCS and 456 eyes undergoing FLACS with Acrysof IOL (Alcon laboratories, Inc) implantation. After optimizing IOL constants, the predicted refractive outcome was calculated for all formulas for each case. This was compared to the actual refractive outcome to provide the prediction error. The performance of CCS and FLACS was compared by the absolute prediction error and percentage of eyes within 0.25D, 0.5D and 1.0D of anticipated refractive outcome.Results: There was no statistically significant difference in median absolute error between the CCS and LACS groups for the Kane (0.256, 0.236; p=0.389), SRK T (0.298, 0.302, p=0.910), Holladay (0.312, 0.275; p=0.090), Hoffer Q (0.314, 0.289; p=0.330), Haigis (0.309, 0.258; p=0.177), Barrett Universal 2(0.250, 0.250; p=0.866), Holladay 2 (0.250, 0.258; p=0.860) and Olsen (0.260, 0.255; p=0.570) formulas. Similarly, there was no consistent difference between the two techniques for percentage of patients within 0.25, 0.50 and 1.0D of predicted refractive outcome for each formula.Conclusion: There was no difference in refractive outcome prediction accuracy

Published
2021

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