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The aquaculture industry heavily relies on fishmeal and fish oil, which are derived from wild fish stocks. With concerns about overfishing and limited marine resources, finding alternative and sustainable feed sources is crucial. Plantbased protein source commonly used in aquaculture feeds. It is rich in protein and has a balanced amino acid profile. However, anti-nutritional factors in plant-based protein sources may impact digestibility in certain species, and plant cultivation practices also raise environmental concerns. Therefore, other sources of feedstuffs need to be investigated to substitute fish meal, fish oil and plant-based protein in aquafeeds without any effect on production. So, Insect Meal is gaining attention as a sustainable and nutritious protein source for aquaculture feeds. They have a high protein content and favourable amino acid profiles and can be produced using organic waste. Due to increasing prices of fish meal and oil, more plant-based material from legumes, oilseeds or cereal gluten has been used in the feed. But, it is difficult to substitute large amounts of fish meal and fish oil with plant-based material. For this reason, insect meal could be beneficial and could replace fish meal or plant content. An alternative to fish meal and soya bean has been found in insect meal. Insects generally consist of 40 to 60% protein. Insect meals can replace fish meals and plant-based ingredients in feed. Insects require less space and utilize less energy for cultivation. Insect meal can be mixed with other feed components to form a mixture of a balanced composition and then pressed into pellets for better and more convenient feeding to cultured species. [ABSTRACT FROM AUTHOR]

The primary focus of this study is to provide classical taxonomic analysis and a detailed description of Paranibea semiluctuosa, a specimen obtained through trawling operations and subsequently brought to the Umargaon fish landing center. A total of 43 morphometric parameters and 21 meristic characters were documented and identified with standard identification keys and the original species descriptions. While, prior reports had identified P. semiluctuosa from the Gulf of Kutch, this study marks a significant milestone as it represents the first documented occurrence of the species from Umargaon. This expanded geographical insight enhances understanding of the species distribution and the importance of its taxonomic description and contributes to the broader knowledge of the regional marine biodiversity of Gujarat. [ABSTRACT FROM AUTHOR]

The present study evaluated the effect of different levels of salinities on growth and survival of Sillago sihama fish fry, commonly known as lady fish. Sillago fish fry were stocked at seven different salinities levels i.e., 0, 10, 20, 30, 40 50 and 60 ppt (T1, T2, T3 T4, T5, T6 and T7, respectively) and reared for a period of 60 days. Fish weighing 2.11 ± 0.02 g were stocked into twenty one 50-litres rectangular crates (triplicates) with 10 fish/crate. Filtered and disinfected rainwater was added to seawater in order to achieve different treatment salinities. During the experimental period, the fish were fed twice daily with a formulated diet (30% crude protein (CP) diet) @ 10% body weight. Growth in terms of body weight (g) and length (cm) were monitored fortnightly and survival (%) was estimated by counting fish from individual crate. A significant (p<0.05) decrease in growth and survival rates relative to the higher and lower salinities level was observed. Increase in salinity levels led to a significant reduction (p<0.05) in body weight and survival of the fish fry. At the end of the experimental period, treatment T4 and T3 recorded higher mean body weight (5.080 and 4.693 g) and higher periodical mean survival rate (96.67% and 93.33%), as compared to rest of the treatments. Similar trend was observed for fish body length, which was positively correlated (r2 = 0.993) with fish body weight. Lowest survival was observed in treatment T1 (0 ppt) and T7 (60 ppt). Fish reared in 20-30 ppt showed better growth and survival which might be due to improved osmoregulation. Results of the study also indicate that rearing of fish is not viable at lower salinities and higher salinities. [ABSTRACT FROM AUTHOR]

The study was carried out to determine clinical signs, hematological and therapeutic efficacy in T. equi infected horses. Clinical signs were pyrexia, anemia, icteric mucus membrane and fetlock swelling. Hematological examination revealed significantly decreased hemoglobin, packed cell volume, RBC and WBC count. The diseased horses were treated with Buparvaquone 4-6 mg/kg b.wt. intramuscularly along with hematinics and fluid therapy. [ABSTRACT FROM AUTHOR]

Purpose: Due to the Corona virus pandemic in 2019, all around the world people had to spend a long time in quarantine. The effect of this life style on the sexual behaviors of couples is an important issue that needs further investigation. The present study mainly aimed to investigate the effects of the COVID-19 outbreak on the sexual behaviors of married couples.Methods: In total, 740 participants completed questionnaires through different online social platforms. The participants were married men and women over 18 years old. The required data were obtained from the sexual behaviors of couple’s questionnaire (Iranian version), Kansas Marital Satisfaction Scale, and demographic variables questionnaire.Results: Data analysis revealed that 56.1% and 49.7% of the participants experienced no changes in their sexual and desire sexual frequency, respectively. According to multiple regression analysis, it was found that satisfaction with the partner, satisfaction with marriage, economic status, emotional relationship, tobacco use, psychiatric disorders have significant relationships with sexual frequency in couples.Conclusions: According to the results, it can be concluded that there were no significant differences in sexual desire, frequency, pleasure and request in married couples during the COVID-19 outbreak.

Objective: To evaluate the presence/severity of depression, anxiety, and stress among health care workers(HCWs) who work on the specially allocated COVID-19 ward (Group A) and HCWs on the other wards(Group B).Methods: This questionnaire-based study was conducted from January 25 to February 28, 2021. The mentalstatus was assessed using the Persian version of the 42-item Depression, Anxiety, and Stress score (DASS-42).Gathered data was analyzed using SPSS version 25. The independent T-test and Chi-square tests were used tocompare quantitative and qualitative variables.Results: Two-hundred and twenty two questionnaires were eligible for analysis. Group A consisted of 33HCWs, and 189 (85.1%) individuals were working on the other wards. No statistically significant differenceswere seen regarding the Socio-demographic features except for the marital status (p=0.005). The depressions’mean score was comparable between group A and B (p=0.102). The mean scores of anxiety and stress weresignificantly lower in group A than group B (p=0.006), although the frequency of DASS-42 parameters did notdiffer between these two groups (p>0.05).Conclusion: Contrary to our assumptions, this study showed that the DASS-42 parameters were not higher inHCWs working on the COVID-19 wards. This might be justified by developing coping mechanisms, being onthe honeymoon phase of the disaster, compassion satisfaction, promising vaccine news, and working on theless impacted hospital.

Graphene oxide (GO) have been synthesized and doped with nickel metal salt under differ thermal conditions. The doped graphene oxides obtained were characterized by Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Raman spectroscopy, and Atomic force spectroscopy AFM). The results obtained indicate difference between the crystallinity pattern of microwave and the conventional heating system of the materials and the progressive formation of transparent and decorated graphene with nickel particles which increases with temperature. [ABSTRACT FROM AUTHOR]

In this paper, we report the synthesis of metal organic framework of uranium 1,2,4,5-benzene tetracarboxylic acid (U-H4btec MOF) by solvothermal method. The obtained MOF was characterized by Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray diffraction spectroscopy (XRD), Energy dispersive spectroscopy (EDS), thermogravimetric and differential thermogravimetric analysis (TGA/DTA). The morphology of the uranium 1,2,4,5-benzene tetracarboxylic acid MOF observed by SEM, revealed the presence of flaky porous structure. Adsorption of Cr3+ from aqueous solution onto the uranium 1,2,4,5-benzene tetracarboxylic acid MOF was systematically studied. Langmuir and Freundlich adsorption isotherms were applied to determine the adsorption capacity of the MOF to form a monolayer. Kinetic determination of the adsorption of Cr3+ suggested both chemisorption and physisorption probably due to the presence of carbonyl groups within the MOF and its porous structure.

Nitrogen doped carbon nanotubes were synthesized using cobalt and silver co-catalyst on magnesium oxide support. Their morphological features were studied using Raman spectroscopy, energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction spectroscopy. Equilibrium and thermodynamic batch sorption experiments were carried using concentration, time and temperature effects respectively. The morphological images showed amorphous multiwall nanotubes with crystalline regions that are attributable to the doping of carbon nanotube with nitrogen. The sorption studies indicated a rapid uptake of Cr3+ by the nitrogen doped carbon nanotubes which was mainly diffusion controlled. The thermodynamic study suggests relatively low temperature (low energy) favoured sorption which is exothermic with a physic-sorption mechanism. [ABSTRACT FROM AUTHOR]

Purpose: To examine disease profile of tubercular uveitis (TBU) in Paediatric population. Methods: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed. Results: Mean age of disease presentation was 12.8 (range 4-18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference ( P =.006 ). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21). Conclusions: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome.

Purpose : To report the clinical findings, anatomical features, and treatment outcomes in subjects with ocular tuberculosis (OTB) at 24 months in the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods : Of the 945 subjects included in COTS-1, those who completed a 24-month follow-up after completion of treatment were included. The main outcome measure was a number of patients with treatment failure (TF). Results : 228 subjects (120 males; mean age of 42.82 ± 14.73 years) were included. Most common phenotype of uveitis was posterior ( n = 81; 35.53%), and panuveitis ( n = 76; 33.33%). Fifty-two patients (22.81%) had TF. On univariable analysis, odds of high TF was observed with bilaterality (OR: 3.46, p = .003), vitreous haze (OR: 2.14, p = .018), and use of immunosuppressive therapies (OR: 5.45, p = .003). However, only bilaterality was significant in the multiple regression model (OR: 2.84; p = .02). Conclusions : Majority of subjects (>75%) achieved cure in the COTS-1 at 24-month follow-up. The concept of "cure" may be a valuable clinical endpoint in trials for OTB.

Purpose: Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP. Methods: Multicentre retrospective analysis. Results A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n = 382/447; 85.4%) and 382 received corticosteroids (n = 382/447; 85.4%). Treatment failure was observed in 78 individuals (n = 78/447; 17.4%), occurring less frequently in patients receiving ATT (n = 66/382; 17.2%) compared to those who did not (n = 12/65; 18.5%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP. Conclusion Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.

Purpose : The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular Anterior Uveitis (TAU) across international centers. Methods : Multicentre retrospective analysis of patients diagnosed with TAU between January 2004 to December 2014 that had a minimum follow-up of 1 year. Results : One hundred and sixty-five patients were included. One hundred and seven subjects received antitubercular therapy (ATT) (n = 107/165; 64.9%) with all the patients receiving topical steroid therapy. Treatment failure was noted in 17 patients (n = 17/165; 10.3%), more frequently described in patients that received ATT (n = 13/107, 12.2%), than those that did not receive ATT (n = 4/58, 6.9%). Conclusion : In this retrospective study, addition of ATT did not have any statistically significant impact on outcome in patients with TAU.

Background: Tuberculosis (TB) is a major infection that can affect the eye as first and sole presentation without features of systemic disease. Controversy exists regarding diagnosis and management of tubercular uveitis (TBU), further compounded by regional variations in disease expression. Purpose: Collaborative Ocular Tuberculosis Study (COTS)-1 aims to address knowledge deficits through collaboration amongst uveitis specialists across the globe by sharing the data of patients with TBU presented at participating centers from January 2004 to December 2014. Methods: Data collection was facilitated by a novel method of real-time encrypted web-based data entry allowing regular updates as new data and recommendations become available. Results: Information on clinical features, investigation findings, management, and treatment outcomes were reviewed to get an idea about real world scenario. Conclusion: The current review aims to focus on methodology and briefing of published reports from COTS group in COTS-1 study to highlight key messages from this large data.

Objective: Aim of the study was to examine extent, natural history, and clinical features associated with visual impairment (VI) in patients diagnosed with ocular tuberculosis (OTB) by the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods: Multi-center retrospective cohort study. Main outcomes were VI. Results: A total of 302 patients were included in the study, including 175 patients whose data related to BCVA were available throughout the 2 years of follow up. Mean BCVA grossly improved at 12, 18, and 24 months of follow-up ( p < .001). Mean BCVA was worse at 12-18th month follow-up for patients treated with ATT versus patients who were not treated with ATT, but patients treated with ATT had a statistically significant improvement in BCVA at the 24-month endpoint. Conclusions: OTB is associated with significant visual morbidity, future well-designed prospective studies are warranted to establish the causal association between OTB and visual loss.

Purpose : To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU). Methods : Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed. Results : 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) ( n  = 219/245, 89.38%), 229 patients with steroids ( n  = 229/245, 93.47%) and 28 patients with immunosuppressive agents ( n  = 28/245, 11.42%). Treatment failure was noted in 38 patients ( n  = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis ( p  = 0.06). Conclusion : This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.

Purpose: To study the structural visibility of the posterior vitreous cavity and vitreoretinal interface using Spectral Domain-Optical Coherence Tomography in patients with uveitis using conventional, Enhanced Depth Imaging (EDI), Combined Depth Imaging (CDI), and Enhanced Vitreous Imaging (EVI) techniques., Methods: It was an observational cross-sectional study of 59 eyes of 33 patients between age group 12-72 years (Median 43) diagnosed as uveitis with posterior segment manifestations underwent OCT using conventional, EDI, CDI, and EVI techniques. The visibility of posterior vitreous was graded in all the techniques., Results: A statistically significant difference was seen in posterior vitreous visibility on comparing all four techniques. EVI showed better visibility of posterior vitreous cavity compared to all other techniques (P < 0.001)., Conclusions: EVI technique provides better structural visibility of posterior vitreous compared to conventional, EDI, and CDI techniques.

Purpose : To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n  = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. Results: 59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation. Conclusions : Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.

Purpose : To quantify biomechanical change associated with autoimmune diseases using Corvis ST deformation data. Methods : Cross-sectional, observational, case control study of 76 patients with systemic autoimmune disease and 21 control subjects. All patients underwent detailed ophthalmic examination with Corvis-ST (Oculus Optikgerate Gmbh, Germany) measurements for biomechanical properties of the eye. Corneal deformation and also deformation caused by the extracorneal tissue were recorded. Using a mathematical formula, the three parameters, namely, corneal stiffness (kc), extracorneal tissue stiffness (kg), and extracorneal tissue viscosity (μg), were defined. Results : The biomechanical analysis showed that kc and μg were significantly lower in patients with systemic autoimmune disease with eye manifestations than control group. However statistically, it was significant in rheumatoid arthritis (RA) patients only. Conclusion : The new parameters, namely, kc, kg, and μg, can provide a sensitive marker of the ocular activity of the collagen vascular diseases.

Purpose: To study the sheathing of retinal vasculitis in various systemic autoimmune diseases using adaptive optics imaging (AOI)., Methods: Prospective, observational case series with six patients: Behçet disease (n = 1); systemic lupus erythematosus (n = 1); idiopathic retinal vasculitis (n = 2); granulomatosis with polyangiitis (n = 1); and Takayasu aorta arteritis (n = 1). Fundus photograph (FP), fundus fluorescein angiography (FFA) were done in all cases at presentation. Using the Image J software, perivascular sheathing and wall-to-wall diameter of the vessel involved were measured on AOI at time of presentation and on follow-up., Results: AOI was able to pick the pipe-stem sheathing in SLE and IRV(I) and parallel sheathing in rest, which correlated with FP and FFA. Moreover, the decrease and a complete resolution in the sheathing were also noted by AOI on follow-up., Conclusions: AOI can be used as an additional investigative tool for diagnosis and to monitor the disease course during the treatment.

Aim: The purpose of this study was to investigate the recovery pattern of the plasma inflammatory markers interleukin-6 (IL-6) and C-reactive protein (CRP) after the single-bout maximal exercise. The exercise of different type (continuous vs. intermittent) was performed and also compared in this study., Methods: Following baseline testing, 30 males were divided into three experimental groups, which completed continuous or intermittent all-out exercise of similar duration or no exercise intervention (Control group). Blood was sampled before and 1 h, 3 h, 5 h after exercise. Serum was analysed for IL-6, CRP, lactate, creatinine, uric acid, cortisol, creatine kinase, lactate dehydrogenase and myoglobin. Diet was standardized during recovery monitoring., Results: Serum IL-6 and CRP concentrations were not significantly changed in the pre- to post-exercise values comparison. These results are evident in both exercise intervention groups as well as in the control group. The only exception is the significant (P=0.03) IL-6 decrease (28.2%) in continuous exercise protocol 3 h after the exercise. Significant changes (P<0.05) were also observed in lactate, cortisol, uric acid and myoglobin, when pre-exercise vs. post-exercise recovery values were compared, Conclusion: The exercise of all-out intensity and relatively short duration, no matter what type, does not elicit a significant change in the inflammatory markers IL-6 and CRP for the 1h to 5h period of rest following the exercise.

Aim: The aim of this study was to assess relationships between cardiac autonomic regulation after exercise and different types of single-bout exercise of a maximal intensity and of a similar duration., Methods: The study group consisted of 30 males (23 ± 2 year old), which was separated into three subgroups. Groups A and B performed exercise interventions (continuous or intermittent), while group C represented the control group. Heart rate variability (HRV) was monitored continuously over 30 min after the exercise and consequently during a 6 h period following intervention. Spectral analysis parameters of HRV (total [PT], low- [PLF], high- [PHF] frequency power, LF/HF, and PLF in normalized units [LFnu]) were determined over 5 min intervals. Heart rate recovery (HRR) was also analysed., Results: There were not significant differences between groups A and B for the entire HRV monitoring (P<0.05) or in the relatively expressed HRR. The cardiac autonomic modulation expressed by PT, PLF, and PHF fully recovered in 120 min after exercise, whereas LF/HF and LFnu did not significantly differ (P<0.05) from the control group 60 min earlier., Conclusion: Cardiac autonomic recovery after all-out exercise is type non-dependent and sympathovagal balance restores faster than the absolute HRV magnitude.

In patients with normal results on stress single-photon emission computed tomographic (SPECT) studies, coronary artery disease risk factors (RFs) and the mode of testing can influence the trajectory of long-term outcomes. Nevertheless, the combined prognostic impact of these commonly assessed factors has heretofore not been considered. In this study, all-cause mortality rates were assessed in 5,762 patients with normal results on stress SPECT studies. Patients were divided according to mode of stress testing, exercise or pharmacologic, and by number of coronary artery disease RFs. Patients were followed for a mean of 8 ± 4.2 years for all-cause mortality. There were 1,051 deaths (18%), with an annualized mortality rate of 2.2% per year. The RF-adjusted event rate was significantly higher for pharmacologic versus exercise SPECT studies (3.6% per year vs 1.2% per year, p <0.0001) and for patients with increasing numbers of coronary artery disease RFs (p <0.0001). Kaplan-Meier survival analysis revealed wide heterogeneity in all-cause mortality rates when RF burden and performance of exercise versus pharmacologic testing were considered, ranging from only 0.8% per year in exercise patients with no RFs to 4.2% per year in pharmacologic patients with ≥2 RFs. Mortality rates in exercise patients with ≥2 RFs were comparable to those in pharmacologic patients with no RFs. In conclusion, long-term outcomes after cardiac stress testing are synergistically and strongly influenced by RF burden and inability to exercise. Given these findings, prospective study is indicated to determine whether enhanced risk categorization that combines the consideration of these 2 factors improves patient counseling and physician risk management among patients manifesting normal results on stress SPECT studies., (Copyright © 2013. Published by Elsevier Inc.)