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10 results on '"Valand, Karishma"'

2. Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

Author

van Maldegem, Febe, Valand, Karishma, Cole, Megan, Patel, Harshil, Angelova, Mihaela, Rana, Sareena, Colliver, Emma, Enfield, Katey, Bah, Nourdine, Kelly, Gavin, Tsang, Victoria Siu Kwan, Mugarza, Edurne, Moore, Christopher, Hobson, Philip, Levi, Dina, Molina-Arcas, Miriam, Swanton, Charles, and Downward, Julian

Published
2021
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3. Therapeutic KRAS G12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers

Author

Mugarza, Edurne, primary, van Maldegem, Febe, additional, Boumelha, Jesse, additional, Moore, Christopher, additional, Rana, Sareena, additional, Llorian Sopena, Miriam, additional, East, Philip, additional, Ambler, Rachel, additional, Anastasiou, Panayiotis, additional, Romero-Clavijo, Pablo, additional, Valand, Karishma, additional, Cole, Megan, additional, Molina-Arcas, Miriam, additional, and Downward, Julian, additional

Published
2022
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4. CBIAS_2021_Poster_17.pdf

Author

Alexandrov, Yuriy, Kumar, Sunil, Smith, Jonathan, Fedoryshchak, Roman, Valand, Karishma, Le Marois, Alix, Dunsby, Christopher, and French, Paul

Subjects
Imaging
Abstract

Method and software for model-based artifact correction in time-lapse fluorescence microscopy images (Presented in CBIAS 2021 Conference in Francis Crick Institute, 22-23 November 2021) Time-lapse microscopy (TLM) is a widely used method for studying dynamic biochemical and morphological responses in biological systems. Unfortunately, fluorescence images often suffer from hardware-dependent intensity artifacts that degrade the quality of the image data. Starting from a general fluorescence image formation model, we have designed several artifact correction methods addressing the most common practical cases. The proposed techniques may correct images for XY-dependent artifacts, including excitation non-uniformity, optical vignetting, and stray light, as well as time-dependent artifacts, e.g., arising from excitation light source power variations during a time course and inherent photobleaching of cell culture medium. We have implemented these methods in a convenient open-source, cross-platform MATLAB software tool with GUI, aiming to make TLM image data more amenable for further quantitative analysis.

Published
2022
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5. Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

Author

Mugarza, Edurne, primary, van Maldegem, Febe, additional, Boumelha, Jesse, additional, Moore, Christopher, additional, Rana, Sareena, additional, Sopena, Miriam Llorian, additional, East, Philip, additional, Ambler, Rachel, additional, Anastasiou, Panayiotis, additional, Clavijo, Pablo Romero, additional, Valand, Karishma, additional, Cole, Megan, additional, Molina-Arcas, Miriam, additional, and Downward, Julian, additional

Published
2021
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6. Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

Author

Maldegem, Febe van, primary, Valand, Karishma, additional, Cole, Megan, additional, Patel, Harshil, additional, Angelova, Mihaela, additional, Rana, Sareena, additional, Colliver, Emma, additional, Enfield, Katey S, additional, Bah, Nourdine, additional, Tsang, Victoria, additional, Mugarza, Edurne, additional, Moore, Christopher, additional, Hobson, Philip, additional, Levi, Dina, additional, Molina-Arcas, Miriam, additional, Swanton, Charles, additional, and Downward, Julian, additional

Published
2021
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7. Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

Author

van Maldegem, Febe, primary, Valand, Karishma, additional, Cole, Megan, additional, Patel, Harshil, additional, Angelova, Mihaela, additional, Rana, Sareena, additional, Colliver, Emma, additional, Enfield, Katey, additional, Bah, Nourdine, additional, Kelly, Gavin, additional, Tsang, Victoria Siu Kwan, additional, Mugarza, Edurne, additional, Moore, Christopher, additional, Hobson, Philip, additional, Levi, Dina, additional, Molina-Arcas, Miriam, additional, Swanton, Charles, additional, and Downward, Julian, additional

Published
2021
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9. Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

Author

van Maldegem, Febe, Valand, Karishma, Cole, Megan, Patel, Harshil, Angelova, Mihaela, Rana, Sareena, Colliver, Emma, Enfield, Katey, Bah, Nourdine, Tsang, Victoria Siu Kwan, Mugarza, Edurne, Moore, Christopher, Hobson, Philip, Levi, Dina, Molina-Arcas, Miriam, Swanton, Charles, and Downward, Julian

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10. Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers.

Author

Mugarza, Edurne, van Maldegem, Febe, Boumelha, Jesse, Moore, Christopher, Rana, Sareena, Sopena, Miriam Llorian, East, Philip, Ambler, Rachel, Anastasiou, Panayiotis, Romero-Clavijo, Pablo, Valand, Karishma, Cole, Megan, Molina-Arcas, Miriam, and Downward, Julian

Subjects
*MACROPHAGE colony-stimulating factor, *T cells, *ANTIGEN presenting cells, *LUNG cancer, *GENETIC regulation, *RAS proteins
Abstract

The article presents a study on a therapeutic KRASG12C (glycine 12 to cysteine) inhibitor that drives effective interferon-mediated antitumor immunity in immunogenic lung cancers. It discusses that the in vivo KRASG12C inhibitor increases the T cell infiltration and activation. It also describes the mechanism of the KRASG12C inhibition reverses immunosuppression in several preclinical lung cancer models with varying levels of immunogenicity.

Published
2022
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